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MIRAGE
Alzheimer's disease

Summary
Synonym
  • Alzheimer disease
  • Alzheimers dementia
Definition
A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
Super Class
tauopathy
Disease Ontology
DOID:10652
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 21 - 30 of 104 in total
Gene ID Gene Symbol Description Source
840 CASP7 caspase 7
1020 CDK5 cyclin dependent kinase 5
1103 CHAT choline O-acetyltransferase
1509 CTSD cathepsin D
1588 CYP19A1 cytochrome P450 family 19 subfamily A member 1
1743 DLST dihydrolipoamide S-succinyltransferase
1889 ECE1 endothelin converting enzyme 1
1965 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha
2023 ENO1 enolase 1
2056 EPO erythropoietin
Displaying all 3 entries
Gene ID Gene Symbol Description Source
11820 App amyloid beta precursor protein
16971 Lrp1 low density lipoprotein receptor-related protein 1
17380 Mme membrane metallo endopeptidase
Displaying entries 11 - 13 of 13 in total
Gene ID Gene Symbol Description Source
83516 Ppargc1a PPARG coactivator 1 alpha
84027 Gsk3b glycogen synthase kinase 3 beta
117029 Ccr5 C-C motif chemokine receptor 5
Displaying all 6 entries
Gene ID Gene Symbol Description Source
31002 Appl beta amyloid protein precursor-like
32342 amrt amaretto
37443 bisc biscotti
40260 Psn Presenilin
42964 Nct Nicastrin
43869 amx almondex
Displaying all 2 entries
Gene ID Gene Symbol Description Source
176282 lin-12 lin-12/Notch intracellular domain
180783 apl-1 Amyloid-beta-like protein
Displaying 1 entry
Gene ID Gene Symbol Description Source
855897 HRR25 serine/threonine protein kinase HRR25
Related Glycoprotein
Displaying 1 entry
UniProt ID Protein Name Source
P29295 Casein kinase I homolog HRR25
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025