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MIRAGE
type 2 diabetes mellitus
Summary
- Synonym
-
- NIDDM
- insulin resistance
- non-insulin-dependent diabetes mellitus
- type 2 diabetes
- type II diabetes mellitus
- Definition
- A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
- Super Class
- diabetes mellitus
External Links
- Disease Ontology
- DOID:9352
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- MGI genotype (from TogoID)
-
- 5504442
- 3760281
- 3766122
- 3789135
- 3842791
- 3847120
- 4361710
- 4429442
- 5294956
- 5301577
- 5428893
- 5435319
- 5502687
- 3721145
- 5620891
- 5637560
- 5638149
- 5695740
- 5766495
- 5789257
- 5804115
- 5804125
- 6111393
- 6160731
- 7314952
- 7622052
- 3531404
- 2175101
- 2177705
- 2385750
- 2385751
- 2653988
- 2654708
- 3028851
- 3029380
- 3051529
- 3052685
- 3510669
- 3510670
- 2174965
- 3531409
- 3582680
- 3583344
- 3583687
- 3583763
- 3583951
- 3583952
- 3586490
- 3590085
- 3623394
- 3629188
- 3694548
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 3767 | KCNJ11 | potassium inwardly rectifying channel subfamily J member 11 | |
| 3784 | KCNQ1 | potassium voltage-gated channel subfamily Q member 1 | |
| 3952 | LEP | leptin | |
| 3953 | LEPR | leptin receptor | |
| 3990 | LIPC | lipase C, hepatic type | |
| 4000 | LMNA | lamin A/C | |
| 4023 | LPL | lipoprotein lipase | |
| 4049 | LTA | lymphotoxin alpha | |
| 4502 | MT2A | metallothionein 2A | |
| 4544 | MTNR1B | melatonin receptor 1B |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 11652 | Akt2 | thymoma viral proto-oncogene 2 | |
| 15560 | Htr2c | 5-hydroxytryptamine (serotonin) receptor 2C | |
| 16334 | Ins2 | insulin II | |
| 16367 | Irs1 | insulin receptor substrate 1 | |
| 16846 | Lep | leptin | |
| 16847 | Lepr | leptin receptor | |
| 18023 | Nfe2l1 | nuclear factor, erythroid derived 2,-like 1 | |
| 18759 | Prkci | protein kinase C, iota | |
| 20526 | Slc2a2 | solute carrier family 2 (facilitated glucose transporter), member 2 | |
| 20528 | Slc2a4 | solute carrier family 2 (facilitated glucose transporter), member 4 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 25634 | G6pc1 | glucose-6-phosphatase catalytic subunit 1 | |
| 25675 | Hmgcr | 3-hydroxy-3-methylglutaryl-CoA reductase | |
| 29473 | Aoc3 | amine oxidase, copper containing 3 | |
| 50672 | Ednrb | endothelin receptor type B | |
| 54315 | Ucp2 | uncoupling protein 2 | |
| 65248 | Prkaa1 | protein kinase AMP-activated catalytic subunit alpha 1 | |
| 83516 | Ppargc1a | PPARG coactivator 1 alpha | |
| 171105 | Lnpep | leucyl and cystinyl aminopeptidase | |
| 260320 | F7 | coagulation factor VII | |
| 310615 | Crtc2 | CREB regulated transcription coactivator 2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 176000 | ogt-1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase;protein O-GlcNAc transferase | |
| 177850 | gon-1 | A disintegrin and metalloproteinase with thrombospondin motifs gon-1;Peptidase M12B domain-containing protein | |
| 266823 | parp-1 | Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1 |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P04179 | Superoxide dismutase [Mn], mitochondrial | |
| P04278 | Sex hormone-binding globulin | |
| P04798 | Cytochrome P450 1A1 | |
| P05090 | Apolipoprotein D | |
| P05091 | Aldehyde dehydrogenase, mitochondrial | |
| P05231 | Interleukin-6 | |
| P06213 | Insulin receptor | |
| P06276 | Cholinesterase | |
| P06858 | Lipoprotein lipase | |
| P08183 | ATP-dependent translocase ABCB1 |
| UniProt ID | Protein Name | Source |
|---|---|---|
| O08590 | Amine oxidase [copper-containing] 3 | |
| P15127 | Insulin receptor | |
| P16599 | Tumor necrosis factor | |
| P20961 | Plasminogen activator inhibitor 1 | |
| P21451 | Endothelin receptor type B | |
| P28840 | Neuroendocrine convertase 1 | |
| P30551 | Cholecystokinin receptor type A | |
| P35570 | Insulin receptor substrate 1 | |
| P43219 | Gastric inhibitory polypeptide receptor | |
| P43428 | Glucose-6-phosphatase catalytic subunit 1 |
| UniProt ID | Protein Name | Source |
|---|---|---|
| P09208 | Insulin-like receptor | |
| Q9VQI9 | AF4/FMR2 family member lilli |
| UniProt ID | Protein Name | Source |
|---|---|---|
| Q19791 | A disintegrin and metalloproteinase with thrombospondin motifs gon-1 |
| UniProt ID | Protein Name | Source |
|---|---|---|
| P38703 | Ceramide synthase LAG1 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0003584 | Late onset |
| HP:0005978 | Type II diabetes mellitus |
| HP:0000855 | Insulin resistance |
| Gene ID | Gene Symbol | Description |
|---|---|---|
| 5167 | ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| 2820 | GPD2 | glycerol-3-phosphate dehydrogenase 2 |
| 6514 | SLC2A2 | solute carrier family 2 member 2 |
| 2645 | GCK | glucokinase |
| 5506 | PPP1R3A | protein phosphatase 1 regulatory subunit 3A |
| 3990 | LIPC | lipase C, hepatic type |
