GlyCosmos Portal

Mus musculus (house mouse)

Summary

Taxonomy ID: 10090
PubChem Taxonomy: 10090

Genes (662) Glycans (1270) Glycoproteins (13000) Lectins (276) Pathways (1335)

Displaying entries **451 - 475** of **1335** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲
CD28 dependent PI3K/Akt signaling	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Mitogen-activated protein kinase kinase kinase 14 Mitogen-activated protein kinase kinase kinase 8 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proline-rich protein 5 Proto-oncogene tyrosine-protein kinase LCK RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Serine/threonine-protein kinase mTOR T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3 Tyrosine-protein kinase Fyn	O08908 P06240 P26450 P31041 P31750 P39688 P42082 P42337 Q00609 Q07174 Q3UUI3 Q60823 Q64143 Q6QI06 Q812A5 Q8BKH7 Q8K4K2 Q9DCJ1 Q9JLN9 Q9WUA6 Q9WUL6 Q9Z2A0	Akt Akt1 Akt2 Akt3 B7 Cd28 Cd80 Cd86 Cot Ctmp Frap Frap1 Fyn Gbl Kiaa1999 Lck Lsk-t Lst8 Map3k14 Map3k8 Mapkap1 Mip1 Mlst8 Mtor Nik Nipk Pdk1 Pdpk1 Pik3ca Pik3r1 Pik3r2 Pik3r3 Protor1 Prr5 Rac Rictor Sin1 Them4 Tpl2 Trb3 Trib3
Regulation of TP53 Activity through Acetylation	Bromodomain and PHD finger-containing protein 3 Bromodomain-containing protein 1 Bromodomain-containing protein 7 Cellular tumor antigen p53 Chromatin modification-related protein MEAF6 Chromodomain-helicase-DNA-binding protein 4 DNA helicase Histone acetyltransferase KAT6A Histone acetyltransferase p300 Histone deacetylase 1 Histone deacetylase 2 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Inhibitor of growth protein 5 Metastasis-associated protein MTA2 Methyl-CpG-binding domain protein 3 Peregrin Protein PML RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Transcriptional repressor p66 alpha Transcriptional repressor p66-beta	B1AR17 B2KF05 B2RRD7 B2RWS6 G5E8P1 O09106 O88665 P02340 P31750 P70288 Q2VPQ9 Q60823 Q60953 Q60972 Q60973 Q6PDQ2 Q8BZ21 Q8CHY6 Q8VHR5 Q9D8Y8 Q9R190 Q9WUA6 Q9Z2D8	Akt Akt1 Akt2 Akt3 Bp75 Brd1 Brd7 Brpf1 Brpf2 Brpf3 Chd3 Chd4 Ep300 Gatad2a Gatad2b Hdac1 Hdac2 Ing5 Kat6a Kiaa4191 Mbd3 Meaf6 Moz Mta1l1 Mta2 Myst3 P300 P53 Pml Rac Rbap46 Rbap48 Rbbp4 Rbbp7 Tp53 Trp53 Yy1bp
TP53 Regulates Metabolic Genes	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 Cytochrome c oxidase assembly protein COX11, mitochondrial Cytochrome c oxidase assembly protein COX14 Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial Cytochrome c oxidase assembly protein COX18, mitochondrial Cytochrome c oxidase assembly protein COX19 Cytochrome c oxidase assembly protein COX20, mitochondrial Cytochrome c oxidase subunit 1 Cytochrome c oxidase subunit 2 Cytochrome c oxidase subunit 3 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase subunit 5B, mitochondrial Cytochrome c oxidase subunit 6A1, mitochondrial Cytochrome c oxidase subunit 6B1 Cytochrome c oxidase subunit 6C Cytochrome c oxidase subunit 7A-related protein, mitochondrial Cytochrome c oxidase subunit 7B, mitochondrial Cytochrome c oxidase subunit 7C, mitochondrial Cytochrome c oxidase subunit 8A, mitochondrial Cytochrome c oxidase subunit NDUFA4 Cytochrome c, somatic DNA damage-inducible transcript 4 protein Fructose-2,6-bisphosphatase TIGAR GTP-binding protein Rheb Glucose-6-phosphate 1-dehydrogenase X Glucose-6-phosphate isomerase Glutaminase kidney isoform, mitochondrial Glutaminase liver isoform, mitochondrial Glutathione peroxidase 2 Glutathione reductase, mitochondrial Hamartin Leucine-rich PPR motif-containing protein, mitochondrial Neutral amino acid transporter 9 Peroxiredoxin-1 Peroxiredoxin-2 Peroxiredoxin-5, mitochondrial Protein SCO1 homolog, mitochondrial Protein SCO2 homolog, mitochondrial RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Serine/threonine-protein kinase mTOR Sestrin-1 Sestrin-2 Sestrin-3 Surfeit locus protein 1 Target of rapamycin complex subunit LST8 Thioredoxin reductase 1, cytoplasmic Thioredoxin Translational activator of cytochrome c oxidase 1 Tuberin	D3Z7P3 O54950 O70456 O88653 P00397 P00405 P00416 P06745 P09925 P10639 P12787 P17665 P19536 P19783 P31750 P35700 P43024 P47791 P56391 P56393 P58006 P58043 P61982 P62259 P62897 P63101 P68254 P68510 P99029 Q00612 Q571F8 Q5EG47 Q5SUC9 Q60823 Q61037 Q61171 Q61387 Q62425 Q64445 Q6NTA4 Q6P8I6 Q6PAM0 Q6PB66 Q7TT45 Q80X95 Q8BGD6 Q8BGM7 Q8BH51 Q8BRK8 Q8BZA9 Q8CF66 Q8K0C8 Q8K0Z7 Q8K4Q0 Q8VC74 Q8VCL2 Q91WG5 Q921J2 Q99K70 Q9CPQ1 Q9CQ22 Q9CQV8 Q9CR63 Q9CYP7 Q9D1L9 Q9D3F7 Q9D7J4 Q9DCJ1 Q9EP53 Q9JHC0 Q9JHS3 Q9JLN9 Q9JMH6 Q9R078 Q9WUA6	Akt Akt1 Akt2 Akt3 COI COII COIII COX2 Ccdc44 Cox11 Cox14 Cox16 Cox18 Cox19 Cox20 Cox4 Cox4a Cox4i1 Cox5a Cox5b Cox6a1 Cox6al Cox6b Cox6b1 Cox6c Cox7a2l Cox7b Cox7c Cox7c1 Cox7rp Cox8 Cox8a Cox8l Coxiv Cycs Ddit4 Dig2 Fam36a Frap Frap1 G6pd G6pd-1 G6pdx Gbl Gls Gls1 Gls2 Gpi Gpi1 Gpx2 Gr1 Gsr Hbxip Kiaa0243 Kiaa0838 Kiaa4146 Lamtor1 Lamtor2 Lamtor3 Lamtor4 Lamtor5 Lrp130 Lrpprc Lst8 Map2k1ip1 Mapbp Mapbpip Mapksp1 Mkrn3 Mlst8 Msp23 Mtco1 Mtco2 Mtco3 Mtor Ndufa4 Oxa1l2 Pa26 Paga Prdx1 Prdx2 Prdx5 Prdx6 Prkaa1 Prkaa2 Prkaac Prkab1 Prkab2 Prkag1 Prkag2 Prkag3 Rac Ragd Raptor Redd1 Rheb Robld3 Rptor Rraga Rragb Rragc Rragd Rtp801 Scaf1 Sco1 Sco2 Sesn1 Sesn2 Sesn3 Sest1 Sfn Silg81 Slc38a9 Surf-1 Surf1 Taco1 Tdpx1 Tdpx2 Tigar Tpx Trxr1 Tsc1 Tsc2 Txn Txn1 Txnrd1 Xip Ywhab Ywhae Ywhag Ywhah Ywhaq Ywhaz mt-Co1 mt-Co2 mt-Co3
Cyclin A:Cdk2-associated events at S phase entry	CDK-activating kinase assembly factor MAT1 CDK5 and ABL1 enzyme substrate 1 Cyclin-A1 Cyclin-A2 Cyclin-H Cyclin-dependent kinase 2 Cyclin-dependent kinase 7 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Fizzy-related protein homolog M-phase inducer phosphatase 1 M-phase inducer phosphatase 2 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Retinoblastoma-associated protein Wee1-like protein kinase	P13405 P30306 P31750 P39689 P46414 P47810 P48964 P51943 P51949 P97377 Q03147 Q60823 Q61456 Q61458 Q9ESJ1 Q9R1K5 Q9WUA6	Akt Akt1 Akt2 Akt3 Cables Cables1 Cak Ccna Ccna1 Ccna2 Ccnh Cdc25a Cdc25b Cdc25m2 Cdc25m3 Cdk2 Cdk7 Cdkn1a Cdkn1b Cdkn2 Cdkn7 Cip1 Crk4 Cyca Cyca2 Fyr Fzr Fzr1 Mat1 Mnat1 Mo15 Mpk-7 Rac Rb-1 Rb1 Waf1 Wee1
Cyclin E associated events during G1/S transition	CDK-activating kinase assembly factor MAT1 CDK5 and ABL1 enzyme substrate 1 Cyclin-H Cyclin-dependent kinase 2 Cyclin-dependent kinase 7 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B G1/S-specific cyclin-E1 G1/S-specific cyclin-E2 M-phase inducer phosphatase 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Retinoblastoma-associated protein Wee1-like protein kinase	P13405 P31750 P39689 P46414 P47810 P48964 P51949 P97377 Q03147 Q60823 Q61457 Q61458 Q9ESJ1 Q9WUA6 Q9Z238	Akt Akt1 Akt2 Akt3 Cables Cables1 Cak Ccne Ccne1 Ccne2 Ccnh Cdc25a Cdc25m3 Cdk2 Cdk7 Cdkn1a Cdkn1b Cdkn2 Cdkn7 Cip1 Crk4 Mat1 Mnat1 Mo15 Mpk-7 Rac Rb-1 Rb1 Waf1 Wee1
VEGFR2 mediated vascular permeability	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Cadherin-5 Calmodulin-1 Catenin alpha-1 Catenin beta-1 Catenin delta-1 Caveolin-1 Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Heat shock protein HSP 90-alpha Junction plakoglobin Nitric oxide synthase 3 Proline-rich protein 5 Proto-oncogene vav RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Ras-related C3 botulinum toxin substrate 1 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase mTOR Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3	O88643 P07901 P0DP26 P26231 P27870 P30999 P31750 P49817 P55284 P63001 P70313 Q02248 Q02257 Q3UUI3 Q60823 Q60992 Q61036 Q6QI06 Q812A5 Q8BKH7 Q8CIN4 Q8K4K2 Q9DCJ1 Q9JLN9 Q9R0C8 Q9WUA6 Q9Z2A0	Akt Akt1 Akt2 Akt3 Calm Calm1 Cam Cam1 Catna1 Catnb Catns Cav Cav1 Cdh5 Ctmp Ctnna1 Ctnnb1 Ctnnd1 Ecnos Frap Frap1 Gbl Hsp86 Hsp86-1 Hsp90aa1 Hspca Jup Kiaa0384 Kiaa1999 Lst8 Mapkap1 Mip1 Mlst8 Mtor Nipk Nos3 Pak-3 Pak1 Pak2 Pak3 Paka Pakb Pdk1 Pdpk1 Protor1 Prr5 Rac Rac1 Rictor Sin1 Stk4 Them4 Trb3 Trib3 Vav Vav1 Vav2 Vav3
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Cyclic AMP-responsive element-binding protein 1 Cyclin-dependent kinase inhibitor 1B Exportin-1 Forkhead box protein O3 Mitogen-activated protein kinase 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Serine/threonine-protein kinase Kist	P31750 P46414 P63085 P97343 Q01147 Q60823 Q6P5F9 Q9WUA6 Q9WVH4	Akt Akt1 Akt2 Akt3 Cdkn1b Creb-1 Creb1 Crm1 Erk2 Fkhr2 Foxo3 Foxo3a Kis Kist Mapk Mapk1 Prkm1 Rac Uhmk1 Xpo1
FLT3 Signaling	Cyclin-dependent kinase inhibitor 1B Fms-related tyrosine kinase 3 ligand Forkhead box protein O3 GRB2-associated-binding protein 2 GRB2-related adaptor protein 2 GTPase HRas GTPase KRas GTPase NRas Growth factor receptor-bound protein 10 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor-type tyrosine-protein kinase FLT3 Son of sevenless homolog 1	O89100 P08556 P26450 P31750 P32883 P42337 P46414 P49772 Q00342 Q60760 Q60823 Q61411 Q62245 Q9WUA6 Q9WVH4 Q9Z1S8	Akt Akt1 Akt2 Akt3 Cdkn1b Fkhr2 Flk-2 Flt-3 Flt3 Flt3l Flt3lg Foxo3 Foxo3a Gab2 Gads Grap2 Grb10 Grb2l Grid Hras Hras1 Kras Kras2 Meg1 Mona Nras Pik3ca Pik3r1 Rac Sos1
Negative regulation of the PI3K/AKT network	Acyl-coenzyme A thioesterase THEM4 PH domain leucine-rich repeat-containing protein phosphatase 1 PH domain leucine-rich repeat-containing protein phosphatase 2 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Tribbles homolog 3	O08586 P31750 Q3UUI3 Q60823 Q8BXA7 Q8CHE4 Q8K4K2 Q9WUA6	Akt Akt1 Akt2 Akt3 Ctmp Kiaa0606 Mmac1 Nipk Phlpp Phlpp1 Phlpp2 Phlppl Plekhe1 Pten Rac Scop Them4 Trb3 Trib3
Downregulation of ERBB2:ERBB3 signaling	E3 ubiquitin-protein ligase NRDP1 Polyubiquitin-B Polyubiquitin-C Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor tyrosine-protein kinase erbB-2 Receptor tyrosine-protein kinase erbB-3 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A140LHZ9 P0CG49 P0CG50 P31750 P56974 P62983 P62984 P70424 Q60823 Q61526 Q80U87 Q8BH75 Q9WUA6	Akt Akt1 Akt2 Akt3 Erbb2 Erbb3 Flrf Kiaa0055 Kiaa3023 Neu Nrdp1 Nrg1 Nrg2 Rac Rnf41 Rps27a Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2 Ubpy Usp8
AKT-mediated inactivation of FOXO1A	Forkhead box protein O1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase	P31750 Q60823 Q9R1E0 Q9WUA6	Akt Akt1 Akt2 Akt3 Fkhr Foxo1 Foxo1a Rac
Integrin signaling	3-phosphoinositide-dependent protein kinase 1 Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin Integrin alpha-IIb Integrin beta-3 Proto-oncogene tyrosine-protein kinase Src RAC-alpha serine/threonine-protein kinase RAS guanyl-releasing protein 1 RAS guanyl-releasing protein 2 Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 Ras-related protein Rap-1A Ras-related protein Rap-1b Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase SYK Tyrosine-protein phosphatase non-receptor type 1 von Willebrand factor	E9PV24 O54890 P05480 P11276 P26039 P31750 P35821 P41241 P48025 P62835 Q8CIZ8 Q8K0E8 Q8R5A3 Q8VCC8 Q8VCM7 Q99JI6 Q9EQZ6 Q9QUG9 Q9QUM0 Q9Z1S3 Q9Z2A0	Akt Akt1 Apbb1ip Cgef2 Csk Epac Epac1 Epac2 Fga Fgb Fgg Fn1 Itga2b Itgb3 Krev-1 Pdk1 Pdpk1 Prel1 Ptpn1 Rac Rap1a Rap1b Rapgef3 Rapgef4 Rasgrp Rasgrp1 Rasgrp2 Src Syk Sykb Tln Tln1 Vwf ptk72
eNOS activation	Acyl-protein thioesterase 1 Calmodulin-1 Caveolin-1 Cytoglobin Heat shock protein HSP 90-alpha N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Nitric oxide synthase 3 Palmitoyltransferase ZDHHC21 RAC-alpha serine/threonine-protein kinase Sepiapterin reductase	P07901 P0DP26 P31750 P49817 P70313 P97823 Q64105 Q9CWS0 Q9CX80 Q9D270	Akt Akt1 Apt1 Calm Calm1 Cam Cam1 Cav Cav1 Cygb Ddah1 Ecnos Gramp3 Hsp86 Hsp86-1 Hsp90aa1 Hspca Lypla1 Nos3 Pla1a Rac Spr Zdhhc21
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 Docking protein 1 E3 ubiquitin-protein ligase CBL Polyubiquitin-B Polyubiquitin-C Protein-tyrosine kinase 6 RAC-alpha serine/threonine-protein kinase Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG49 P0CG50 P22682 P31750 P62983 P62984 P97465 Q4LDD4 Q64434	Akt Akt1 Arap1 Cbl Centd2 Dok Dok1 Kiaa0782 Ptk6 Rac Rps27a Sik Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2
Extra-nuclear estrogen signaling	72 kDa type IV collagenase Amphiregulin Calmodulin-1 Caveolin-1 Caveolin-2 Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(i) subunit alpha-1 Guanine nucleotide-binding protein G(i) subunit alpha-2 Guanine nucleotide-binding protein G(i) subunit alpha-3 Guanine nucleotide-binding protein G(t) subunit alpha-3 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Heat shock protein HSP 90-alpha Insulin-like growth factor 1 receptor Matrilysin Matrix metalloproteinase-9 Nitric oxide synthase 3 Palmitoyltransferase ZDHHC21 Palmitoyltransferase ZDHHC7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein arginine N-methyltransferase 1 Proto-oncogene tyrosine-protein kinase Src Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase Sphingosine 1-phosphate receptor 3 Sphingosine kinase 1 Striatin Stromelysin-1	B2RSH2 O08537 O08908 O55106 P01132 P05480 P07901 P08752 P0DP26 P19785 P26450 P28862 P29387 P31750 P31955 P33434 P41245 P42337 P48030 P49817 P50153 P61953 P62874 P62880 P62881 P63078 P63213 P63216 P70313 Q01279 Q05928 Q06186 Q10738 Q3V3I2 Q60751 Q61011 Q61012 Q61016 Q61017 Q61521 Q64143 Q80SZ7 Q8CI15 Q91WU6 Q924X1 Q9CXP8 Q9D270 Q9DAS9 Q9DC51 Q9JIF0 Q9JMF3 Q9WVC3 Q9Z0U9	Akt Akt1 Areg Bcn Btc Calm Calm1 Cam Cam1 Cav Cav1 Cav2 Clg4b Dtr Ecnos Edg3 Egf Egfr Epgn Ereg Esr Esr1 Esr2 Estr Estra Estrb Gnai-1 Gnai-2 Gnai1 Gnai2 Gnai3 Gnat3 Gnb1 Gnb2 Gnb3 Gnb4 Gnb5 Gng1 Gng10 Gng11 Gng12 Gng13 Gng2 Gng3 Gng4 Gng5 Gng7 Gng8 Gng9 Gngt1 Gngt11 Gngt2 Gngt3 Gngt4 Gngt5 Gngt7 Gngt8 Gngt9 Gramp2 Gramp3 Hbegf Hegfl Hrmt1l2 Hsp86 Hsp86-1 Hsp90aa1 Hspca Igf1r Lpb3 Mmp2 Mmp3 Mmp7 Mmp9 Mrmt1 Nos3 Nr3a1 Nr3a2 Pik3ca Pik3r1 Pik3r2 Pik3r3 Prmt1 Rac S1pr3 Sdgf Sk1 Sphk1 Src Strn Tgfa Zdhhc21 Zdhhc7
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	14-3-3 protein beta/alpha 5'-3' exoribonuclease 1 Exosome complex component CSL4 Exosome complex component MTR3 Exosome complex component RRP40 Exosome complex component RRP41 Exosome complex component RRP43 Exosome complex component RRP45 Exosome complex component RRP46 Exosome complex component RRP4 Exosome complex exonuclease RRP42 Exosome complex exonuclease RRP44 MAP kinase-activated protein kinase 2 RAC-alpha serine/threonine-protein kinase m7GpppN-mRNA hydrolase mRNA decay activator protein ZFP36L1 mRNA-decapping enzyme 1A	P23950 P31750 P49138 P97789 Q7TQK4 Q8BTW3 Q8VBV3 Q91YD3 Q921I9 Q9CQV8 Q9CRA8 Q9CSH3 Q9CYC6 Q9D0M0 Q9D753 Q9DAA6 Q9JHI7	Akt Akt1 Brf1 Csl4 D7Wsu180e Dcp1a Dcp2 Dhm2 Dis3 Exo Exosc1 Exosc2 Exosc3 Exosc4 Exosc5 Exosc6 Exosc7 Exosc8 Exosc9 Kiaa1008 Mapkapk2 Mitc1 Mtr3 Pmscl1 Rac Rps6kc1 Rrp4 Rrp40 Rrp41 Rrp42 Rrp43 Rrp44 Rrp46 Sep1 Smif Tis11b Xrn1 Ywhab Zfp36l1
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	6-pyruvoyl tetrahydrobiopterin synthase Calmodulin-1 GTP cyclohydrolase 1 feedback regulatory protein GTP cyclohydrolase 1 Heat shock protein HSP 90-alpha Nitric oxide synthase 3 RAC-alpha serine/threonine-protein kinase Sepiapterin reductase cGMP-dependent protein kinase 2	P07901 P0DP26 P31750 P70313 P99025 Q05915 Q61410 Q64105 Q9R1Z7	Akt Akt1 Calm Calm1 Cam Cam1 Ecnos Gch Gch1 Gchfr Gfrp Hsp86 Hsp86-1 Hsp90aa1 Hspca Nos3 Prkg2 Prkgr2 Pts Rac Spr
KSRP (KHSRP) binds and destabilizes mRNA	14-3-3 protein zeta/delta Exosome complex component CSL4 Exosome complex component MTR3 Exosome complex component RRP40 Exosome complex component RRP41 Exosome complex component RRP43 Exosome complex component RRP45 Exosome complex component RRP46 Exosome complex component RRP4 Exosome complex exonuclease RRP42 Exosome complex exonuclease RRP44 Far upstream element-binding protein 2 Poly(A)-specific ribonuclease PARN RAC-alpha serine/threonine-protein kinase m7GpppN-mRNA hydrolase	P31750 P63101 Q3U0V1 Q7TQK4 Q8BTW3 Q8VBV3 Q8VDG3 Q921I9 Q9CRA8 Q9CSH3 Q9CYC6 Q9D0M0 Q9D753 Q9DAA6 Q9JHI7	Akt Akt1 Csl4 D7Wsu180e Dcp2 Dis3 Exosc1 Exosc2 Exosc3 Exosc4 Exosc5 Exosc6 Exosc7 Exosc8 Exosc9 Fubp2 Khsrp Kiaa1008 Mtr3 Parn Pmscl1 Rac Rrp4 Rrp40 Rrp41 Rrp42 Rrp43 Rrp44 Rrp46 Ywhaz
Negative regulation of NOTCH4 signaling	Neurogenic locus notch homolog protein 4 RAC-alpha serine/threonine-protein kinase	P31695 P31750	Akt Akt1 Int-3 Int3 Notch4 Rac
HSF1-dependent transactivation	Alpha-crystallin B chain Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma DnaJ homolog subfamily B member 1 Heat shock 70 kDa protein 1-like Heat shock 70 kDa protein 1A Heat shock 70 kDa protein 1B Heat shock cognate 71 kDa protein Heat shock factor protein 1 Heat shock factor-binding protein 1 Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Heat shock protein beta-8 Proline-rich AKT1 substrate 1 Regulatory-associated protein of mTOR Serine/threonine-protein kinase mTOR Target of rapamycin complex subunit LST8	P07901 P11499 P11798 P16627 P17879 P23927 P28652 P38532 P63017 Q61696 Q6PHZ2 Q8K4Q0 Q923T9 Q9CQZ1 Q9D1F4 Q9DCJ1 Q9JK92 Q9JLN9 Q9QYJ3	Akt1s1 Camk2a Camk2b Camk2d Camk2g Crya2 Cryab Cryac Dnajb1 Frap Frap1 Gbl Hcp70.1 Hsbp1 Hsc70 Hsc70t Hsc73 Hsf1 Hsp22 Hsp40 Hsp70-1 Hsp70-3 Hsp70A1 Hsp70a1 Hsp84 Hsp84-1 Hsp86 Hsp86-1 Hsp90aa1 Hsp90ab1 Hspa1 Hspa1a Hspa1b Hspa1l Hspa8 Hspb8 Hspc3 Hspca Hspcb Hspf1 Kiaa4163 Lst8 Mlst8 Mtor Pras Raptor Rptor
mTORC1-mediated signalling	14-3-3 protein beta/alpha Eukaryotic elongation factor 2 kinase Eukaryotic translation initiation factor 4 gamma 1 Eukaryotic translation initiation factor 4B Eukaryotic translation initiation factor 4E-binding protein 1 Eukaryotic translation initiation factor 4E GTP-binding protein Rheb Neutral amino acid transporter 9 Peptidyl-prolyl cis-trans isomerase FKBP1A Proline-rich AKT1 substrate 1 Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Ribosomal protein S6 kinase beta-1 Serine/threonine-protein kinase mTOR Small ribosomal subunit protein eS6 Target of rapamycin complex subunit LST8	O08796 O88653 P26883 P62754 P63073 Q60876 Q6NTA4 Q6NZJ6 Q7TT45 Q80X95 Q8BGD6 Q8BGD9 Q8BSK8 Q8CF66 Q8K4Q0 Q921J2 Q99K70 Q9CQ22 Q9CQV8 Q9D1F4 Q9D1L9 Q9DCJ1 Q9JHS3 Q9JLN9	Akt1s1 Eef2k Eif4b Eif4e Eif4ebp1 Eif4g1 Fkbp1 Fkbp1a Frap Frap1 Gbl Hbxip Lamtor1 Lamtor2 Lamtor3 Lamtor4 Lamtor5 Lst8 Map2k1ip1 Mapbp Mapbpip Mapksp1 Mlst8 Mtor Pras Ragd Raptor Rheb Robld3 Rps6 Rps6kb1 Rptor Rraga Rragb Rragc Rragd Slc38a9 Xip Ywhab
Activation of PKB	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 RAC-beta serine/threonine-protein kinase Tribbles homolog 3	Q3UUI3 Q60823 Q8K4K2 Q9Z2A0	Akt2 Ctmp Nipk Pdk1 Pdpk1 Them4 Trb3 Trib3
Inhibition of TSC complex formation by PKB	Hamartin RAC-beta serine/threonine-protein kinase Tuberin	Q60823 Q61037 Q9EP53	Akt2 Kiaa0243 Tsc1 Tsc2
Tyrosine catabolism	4-hydroxyphenylpyruvate dioxygenase Fumarylacetoacetase Homogentisate 1,2-dioxygenase Maleylacetoacetate isomerase Tyrosine aminotransferase	O09173 P35505 P49429 Q8QZR1 Q9WVL0	Aku Fah Gstz1 Hgd Hgo Hpd Maai Tat
Regulation of FZD by ubiquitination	E3 ubiquitin-protein ligase RNF43 E3 ubiquitin-protein ligase ZNRF3 Frizzled-4 Frizzled-5 Frizzled-6 Frizzled-8 Insulin-like growth factor-binding protein complex acid labile subunit Leucine-rich repeat-containing G-protein coupled receptor 5 Low-density lipoprotein receptor-related protein 5 Low-density lipoprotein receptor-related protein 6 Polyubiquitin-B Polyubiquitin-C Protein Wnt-3a R-spondin-1 R-spondin-2 R-spondin-3 R-spondin-4 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O88572 P0CG49 P0CG50 P27467 P62983 P62984 P70389 Q2TJ95 Q5NCP0 Q5SSZ7 Q61088 Q61089 Q61091 Q80U87 Q8BFU0 Q8BJ73 Q91VN0 Q9EQD0 Q9Z132 Q9Z1P4	Albs Als Fex Fzd4 Fzd5 Fzd6 Fzd8 Gpr49 Igfals Kiaa0055 Lgr5 Lr3 Lrp5 Lrp6 Lrp7 Rnf43 Rps27a Rspo1 Rspo2 Rspo3 Rspo4 Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2 Ubpy Usp8 Wnt-3a Wnt3a Znrf3

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