GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **1076 - 1100** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲	Organism
HDR through Homologous Recombination (HRR)	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA polymerase eta DNA polymerase kappa DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O15315 O43502 O43542 O43543 O60934 O75771 P0CG47 P0CG48 P12004 P15927 P27694 P28340 P35244 P35249 P35250 P35251 P38398 P40937 P40938 P49005 P49959 P51530 P51587 P54132 P56282 P60896 P62979 P62987 Q06609 Q07864 Q13315 Q13472 Q14191 Q15054 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9HCU8 Q9NR33 Q9NRF9 Q9UBT6 Q9UQ84 Q9Y253	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CHRAC17 CTIP DINB1 DNA2 DNA2L DPE2 DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0039 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PCNA PIR51 POLD POLD1 POLD2 POLD3 POLD4 POLDS POLE POLE1 POLE2 POLE3 POLE4 POLH POLK RAD30 RAD30A RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RMI1 RMI2 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WRN XPV XRCC2 XRCC3	Homo sapiens (human)
Homologous DNA Pairing and Strand Exchange	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43542 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2 XRCC3	Homo sapiens (human)
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2	Homo sapiens (human)
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2	Homo sapiens (human)
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2	Homo sapiens (human)
Impaired BRCA2 binding to PALB2	BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C9orf76 CTIP DNA2 DNA2L EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 TIP60 TOP3 TOP3A WRN XRCC2	Homo sapiens (human)
Regulation of TP53 Activity through Methylation	Cellular tumor antigen p53 E3 ubiquitin-protein ligase Mdm2 Histone acetyltransferase p300 Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Junction-mediating and -regulatory protein Lethal(3)malignant brain tumor-like protein 1 N-lysine methyltransferase KMT5A N-lysine methyltransferase SMYD2 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Protein arginine N-methyltransferase 5 SET domain-containing protein 9 Serine-protein kinase ATM Serine/threonine-protein kinase Chk2 Tetratricopeptide repeat protein 5 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14744 O15151 O96017 P04637 P0CG47 P0CG48 P62979 P62987 Q00987 Q09472 Q13315 Q8N0Z6 Q8N9B5 Q8NE22 Q96KQ7 Q9H9B1 Q9NQR1 Q9NRG4 Q9Y468	ATM BAT8 C5orf35 C6orf30 CDS1 CHEK2 CHK2 EHMT1 EHMT2 EP300 EUHMTASE1 G9A GLP HRMT1L5 IBP72 JBP1 JMY KIAA0681 KIAA1876 KMT1C KMT1D KMT3C KMT5A L3MBT L3MBTL L3MBTL1 MDM2 MDM4 MDMX NG36 P300 P53 PRMT5 PRSET7 RAD53 RPS27A SET07 SET8 SETD8 SETD9 SKB1 SMYD2 TP53 TTC5 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Stabilization of p53	Cellular tumor antigen p53 E3 ubiquitin-protein ligase Mdm2 PHD finger protein 20 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Serine-protein kinase ATM Serine/threonine-protein kinase Chk2 Tumor suppressor ARF Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O15151 O96017 P04637 P0CG47 P0CG48 P62979 P62987 Q00987 Q13315 Q8N726 Q9BVI0	ATM C20orf104 CDKN2 CDKN2A CDS1 CHEK2 CHK2 GLEA2 HCA58 MDM2 MDM4 MDMX MLM NZF P53 PHF20 RAD53 RPS27A TP53 TZP UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Sensing of DNA Double Strand Breaks	DNA repair protein RAD50 Double-strand break repair protein MRE11 Histone acetyltransferase KAT5 Importin subunit alpha-1 Nibrin Serine-protein kinase ATM	O60934 P49959 P52292 Q13315 Q92878 Q92993	ATM HNGS1 HTATIP KAT5 KPNA2 MRE11 MRE11A NBN NBS NBS1 P95 RAD50 RCH1 SRP1 TIP60	Homo sapiens (human)
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	CREB-binding protein Hepatocyte nuclear factor 1-beta Hepatocyte nuclear factor 6 Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase p300 Mastermind-like domain-containing protein 1 Mastermind-like protein 1 Mastermind-like protein 2 Mastermind-like protein 3 Neurogenic locus notch homolog protein 1 Neurogenin-3 One cut domain family member 3 Recombining binding protein suppressor of hairless SNW domain-containing protein 1 Transcription factor HES-1	O60422 P35680 P46531 Q06330 Q09472 Q13495 Q13573 Q14469 Q8IZL2 Q92585 Q92793 Q92830 Q92831 Q96JK9 Q9UBC0 Q9Y4Z2	ATOH5 BHLHA7 BHLHB39 CBP CG1 CREBBP CXorf6 EP300 GCN5 GCN5L2 HES1 HL HNF1B HNF6 HNF6A HRY IGKJRB IGKJRB1 KAT2A KAT2B KIAA0200 KIAA1816 KIAA1819 MAML1 MAML2 MAML3 MAMLD1 NEUROG3 NGN3 NOTCH1 ONECUT1 ONECUT3 P300 PCAF RBPJ RBPJK RBPSUH SKIIP SKIP SNW1 TAN1 TCF2	Homo sapiens (human)
Reduction of cytosolic Ca++ levels	Calmodulin-1 Plasma membrane calcium-transporting ATPase 1 Plasma membrane calcium-transporting ATPase 2 Plasma membrane calcium-transporting ATPase 3 Plasma membrane calcium-transporting ATPase 4 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Sodium/calcium exchanger 1 Sodium/calcium exchanger 2 Sodium/calcium exchanger 3 Sorcin	O14983 P0DP23 P16615 P20020 P23634 P30626 P32418 P57103 Q01814 Q16720 Q93084 Q9UPR5	ATP2A1 ATP2A2 ATP2A3 ATP2B ATP2B1 ATP2B2 ATP2B3 ATP2B4 CALM CALM1 CAM CAM1 CNC KIAA1087 MXRA1 NCX1 NCX2 NCX3 PMCA1 PMCA2 SLC8A1 SLC8A2 SLC8A3 SRI	Homo sapiens (human)
Pre-NOTCH Processing in Golgi	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe Beta-1,3-N-acetylglucosaminyltransferase manic fringe Beta-1,3-N-acetylglucosaminyltransferase radical fringe Beta-1,4-galactosyltransferase 1 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 Furin Neurogenic locus notch homolog protein 1 Neurogenic locus notch homolog protein 2 Neurogenic locus notch homolog protein 3 Neurogenic locus notch homolog protein 4 Protein sel-1 homolog 1 Ras-related protein Rab-6A Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Transmembrane emp24 domain-containing protein 2 Type 2 lactosamine alpha-2,3-sialyltransferase	O00587 O14983 P09958 P15291 P16615 P20340 P46531 Q04721 Q11203 Q11206 Q15363 Q8NES3 Q93084 Q99466 Q9UBV2 Q9UM47 Q9Y274 Q9Y644	ATP2A1 ATP2A2 ATP2A3 ATP2B B4GALT1 CGS23 FUR FURIN GGTB2 INT3 LFNG MFNG NANTA3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PACE PCSK3 RAB6 RAB6A RFNG RNP24 SEL1L SIAT10 SIAT4C SIAT6 ST3GAL3 ST3GAL4 ST3GAL6 STZ TAN1 TMED2 TSA305	Homo sapiens (human)
Formation of ATP by chemiosmotic coupling	ATP synthase F(0) complex subunit B1, mitochondrial ATP synthase F(0) complex subunit C1, mitochondrial ATP synthase F(0) complex subunit C2, mitochondrial ATP synthase F(0) complex subunit C3, mitochondrial ATP synthase membrane subunit K, mitochondrial ATP synthase protein 8 ATP synthase subunit ATP5MJ, mitochondrial ATP synthase subunit O, mitochondrial ATP synthase subunit a ATP synthase subunit alpha, mitochondrial ATP synthase subunit beta, mitochondrial ATP synthase subunit d, mitochondrial ATP synthase subunit delta, mitochondrial ATP synthase subunit e, mitochondrial ATP synthase subunit epsilon, mitochondrial ATP synthase subunit f, mitochondrial ATP synthase subunit g, mitochondrial ATP synthase subunit gamma, mitochondrial ATP synthase subunit s, mitochondrial ATP synthase-coupling factor 6, mitochondrial	O75947 O75964 P00846 P03928 P05496 P06576 P18859 P24539 P25705 P30049 P36542 P48047 P48201 P56134 P56378 P56381 P56385 Q06055 Q96IX5 Q99766	ATP5A ATP5A1 ATP5AL2 ATP5B ATP5C ATP5C1 ATP5CL1 ATP5D ATP5E ATP5F1 ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5G1 ATP5G2 ATP5G3 ATP5H ATP5I ATP5J ATP5J2 ATP5JL ATP5K ATP5L ATP5MC1 ATP5MC2 ATP5MC3 ATP5MD ATP5ME ATP5MF ATP5MG ATP5MJ ATP5MK ATP5MPL ATP5O ATP5PB ATP5PD ATP5PF ATP5PO ATP5S ATP6 ATP8 ATPASE6 ATPASE8 ATPM ATPMB ATPO ATPSB ATPW C14orf2 DAPIT DMAC2L HCVFTP2 MP68 MT-ATP6 MT-ATP8 MTATP6 MTATP8 USMG5	Homo sapiens (human)
Insulin receptor recycling	Cathepsin D Insulin receptor Insulin-degrading enzyme Insulin Receptor-type tyrosine-protein phosphatase F Tyrosine-protein phosphatase non-receptor type 1 V-type proton ATPase 116 kDa subunit a 1 V-type proton ATPase 116 kDa subunit a 2 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 116 kDa subunit a 4 V-type proton ATPase 16 kDa proteolipid subunit c V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit B, kidney isoform V-type proton ATPase subunit C 1 V-type proton ATPase subunit C 2 V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit E 2 V-type proton ATPase subunit F V-type proton ATPase subunit G 1 V-type proton ATPase subunit G 2 V-type proton ATPase subunit G 3 V-type proton ATPase subunit H V-type proton ATPase subunit S1 V-type proton ATPase subunit d 1 V-type proton ATPase subunit d 2 V-type proton ATPase subunit e 1 V-type proton ATPase subunit e 2	O15342 O75348 O95670 P01308 P06213 P07339 P10586 P14735 P15313 P18031 P21281 P21283 P27449 P36543 P38606 P61421 Q13488 Q15904 Q16864 Q8N8Y2 Q8NEY4 Q8NHE4 Q93050 Q96A05 Q96LB4 Q99437 Q9HBG4 Q9UI12 Q9Y487 Q9Y5K8	ATP6A1 ATP6AP1 ATP6B1 ATP6B2 ATP6C ATP6D ATP6E ATP6E1 ATP6E2 ATP6EL2 ATP6F ATP6G ATP6G1 ATP6G2 ATP6G3 ATP6H ATP6IP1 ATP6J ATP6L ATP6M ATP6N1 ATP6N1A ATP6N1B ATP6N1C ATP6N2 ATP6S1 ATP6S14 ATP6V0A1 ATP6V0A2 ATP6V0A3 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E ATP6V0E1 ATP6V0E2 ATP6V0E2L ATP6V1A ATP6V1A1 ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1EL2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATPL C7orf32 CPSD CTSD IDE INS INSR LAR NG38 PTP1B PTPN1 PTPRF TCIRG1 VATB VATC VATD VATF VATPS1 VPATPD VPP1 VPP2 VPP3 XAP3	Homo sapiens (human)
Transferrin endocytosis and recycling	Hereditary hemochromatosis protein Metalloreductase STEAP3 Metalloreductase STEAP4 Mucolipin-1 Serotransferrin Transferrin receptor protein 1 Transferrin receptor protein 2 V-type proton ATPase 116 kDa subunit a 1 V-type proton ATPase 116 kDa subunit a 2 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 116 kDa subunit a 4 V-type proton ATPase 16 kDa proteolipid subunit c V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit B, kidney isoform V-type proton ATPase subunit C 1 V-type proton ATPase subunit C 2 V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit E 2 V-type proton ATPase subunit F V-type proton ATPase subunit G 1 V-type proton ATPase subunit G 2 V-type proton ATPase subunit G 3 V-type proton ATPase subunit H V-type proton ATPase subunit S1 V-type proton ATPase subunit d 1 V-type proton ATPase subunit d 2 V-type proton ATPase subunit e 1 V-type proton ATPase subunit e 2	O15342 O75348 O95670 P02786 P02787 P15313 P21281 P21283 P27449 P36543 P38606 P61421 Q13488 Q15904 Q16864 Q30201 Q658P3 Q687X5 Q8N8Y2 Q8NEY4 Q8NHE4 Q93050 Q96A05 Q96LB4 Q99437 Q9GZU1 Q9HBG4 Q9UI12 Q9UP52 Q9Y487 Q9Y5K8	ATP6A1 ATP6AP1 ATP6B1 ATP6B2 ATP6C ATP6D ATP6E ATP6E1 ATP6E2 ATP6EL2 ATP6F ATP6G ATP6G1 ATP6G2 ATP6G3 ATP6H ATP6IP1 ATP6J ATP6L ATP6M ATP6N1 ATP6N1A ATP6N1B ATP6N1C ATP6N2 ATP6S1 ATP6S14 ATP6V0A1 ATP6V0A2 ATP6V0A3 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E ATP6V0E1 ATP6V0E2 ATP6V0E2L ATP6V1A ATP6V1A1 ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1EL2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATPL C7orf32 HFE HLAH MCOLN1 ML4 NG38 STAMP2 STEAP3 STEAP4 TCIRG1 TF TFR2 TFRC TNFAIP9 TRPML1 TSAP6 VATB VATC VATD VATF VATPS1 VPATPD VPP1 VPP2 VPP3 XAP3	Homo sapiens (human)
Ion channel transport	V-type proton ATPase 116 kDa subunit a 1 V-type proton ATPase 116 kDa subunit a 2 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 116 kDa subunit a 4 V-type proton ATPase 16 kDa proteolipid subunit c V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit B, kidney isoform V-type proton ATPase subunit C 1 V-type proton ATPase subunit C 2 V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit E 2 V-type proton ATPase subunit F V-type proton ATPase subunit G 1 V-type proton ATPase subunit G 2 V-type proton ATPase subunit G 3 V-type proton ATPase subunit H V-type proton ATPase subunit S1 V-type proton ATPase subunit d 1 V-type proton ATPase subunit d 2 V-type proton ATPase subunit e 1 V-type proton ATPase subunit e 2	O15342 O75348 O95670 P15313 P21281 P21283 P27449 P36543 P38606 P61421 Q13488 Q15904 Q16864 Q8N8Y2 Q8NEY4 Q8NHE4 Q93050 Q96A05 Q96LB4 Q99437 Q9HBG4 Q9UI12 Q9Y487 Q9Y5K8	ATP6A1 ATP6AP1 ATP6B1 ATP6B2 ATP6C ATP6D ATP6E ATP6E1 ATP6E2 ATP6EL2 ATP6F ATP6G ATP6G1 ATP6G2 ATP6G3 ATP6H ATP6IP1 ATP6J ATP6L ATP6M ATP6N1 ATP6N1A ATP6N1B ATP6N1C ATP6N2 ATP6S1 ATP6S14 ATP6V0A1 ATP6V0A2 ATP6V0A3 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E ATP6V0E1 ATP6V0E2 ATP6V0E2L ATP6V1A ATP6V1A1 ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1EL2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATPL C7orf32 NG38 TCIRG1 VATB VATC VATD VATF VATPS1 VPATPD VPP1 VPP2 VPP3 XAP3	Homo sapiens (human)
ROS and RNS production in phagocytes	Cytochrome b-245 heavy chain Cytochrome b-245 light chain Natural resistance-associated macrophage protein 1 Neutrophil cytosol factor 1 Neutrophil cytosol factor 2 Neutrophil cytosol factor 4 Nitric oxide synthase 1 Nitric oxide synthase 3 Nitric oxide synthase, inducible Ras-related C3 botulinum toxin substrate 2 V-type proton ATPase 116 kDa subunit a 1 V-type proton ATPase 116 kDa subunit a 2 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 116 kDa subunit a 4 V-type proton ATPase 16 kDa proteolipid subunit c V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit B, kidney isoform V-type proton ATPase subunit C 1 V-type proton ATPase subunit C 2 V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit E 2 V-type proton ATPase subunit F V-type proton ATPase subunit G 1 V-type proton ATPase subunit G 2 V-type proton ATPase subunit G 3 V-type proton ATPase subunit H V-type proton ATPase subunit d 1 V-type proton ATPase subunit d 2 V-type proton ATPase subunit e 1 V-type proton ATPase subunit e 2 Voltage-gated hydrogen channel 1	O15342 O75348 O95670 P04839 P13498 P14598 P15153 P15313 P19878 P21281 P21283 P27449 P29474 P29475 P35228 P36543 P38606 P49279 P61421 Q13488 Q15080 Q16864 Q8N8Y2 Q8NEY4 Q8NHE4 Q93050 Q96A05 Q96D96 Q96LB4 Q99437 Q9HBG4 Q9UI12 Q9Y487 Q9Y5K8	ATP6A1 ATP6B1 ATP6B2 ATP6C ATP6D ATP6E ATP6E1 ATP6E2 ATP6EL2 ATP6F ATP6G ATP6G1 ATP6G2 ATP6G3 ATP6H ATP6J ATP6L ATP6M ATP6N1 ATP6N1A ATP6N1B ATP6N1C ATP6N2 ATP6S14 ATP6V0A1 ATP6V0A2 ATP6V0A3 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E ATP6V0E1 ATP6V0E2 ATP6V0E2L ATP6V1A ATP6V1A1 ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1EL2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATPL C7orf32 CYBA CYBB HVCN1 LSH NCF1 NCF2 NCF4 NG38 NOS1 NOS2 NOS2A NOS3 NOX2 NOXA2 NOXO2 NRAMP NRAMP1 P67PHOX RAC2 SH3PXD1A SH3PXD4 SLC11A1 TCIRG1 VATB VATC VATD VATF VPATPD VPP1 VPP2 VPP3 VSOP	Homo sapiens (human)
Amino acids regulate mTORC1	Cytosolic arginine sensor for mTORC1 subunit 1 Cytosolic arginine sensor for mTORC1 subunit 2 Folliculin-interacting protein 1 Folliculin-interacting protein 2 Folliculin GATOR1 complex protein DEPDC5 GATOR1 complex protein NPRL2 GATOR1 complex protein NPRL3 GATOR2 complex protein MIOS GATOR2 complex protein WDR24 GATOR2 complex protein WDR59 GTP-binding protein Rheb KICSTOR complex protein ITFG2 KICSTOR complex protein SZT2 KICSTOR complex protein kaptin KICSTOR subunit 2 Neutral amino acid transporter 9 Nucleoporin SEH1 Protein SEC13 homolog Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR S-adenosylmethionine sensor upstream of mTORC1 SH3 domain-binding protein 4 Serine/threonine-protein kinase mTOR Sestrin-1 Sestrin-2 Target of rapamycin complex subunit LST8 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 16 kDa proteolipid subunit c V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit B, kidney isoform V-type proton ATPase subunit C 1 V-type proton ATPase subunit C 2 V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit E 2 V-type proton ATPase subunit F V-type proton ATPase subunit G 1 V-type proton ATPase subunit G 2 V-type proton ATPase subunit G 3 V-type proton ATPase subunit H V-type proton ATPase subunit d 1 V-type proton ATPase subunit d 2 V-type proton ATPase subunit e 1 V-type proton ATPase subunit e 2	A6NHX0 O15342 O43504 O75140 O75348 O95670 P15313 P21281 P21283 P27449 P36543 P38606 P42345 P55735 P58004 P61421 Q0VGL1 Q12980 Q13488 Q15382 Q16864 Q1RMZ1 Q5T011 Q5VZM2 Q6IAA8 Q6PJI9 Q7L523 Q8N122 Q8N8Y2 Q8NBW4 Q8NEY4 Q8NFG4 Q8NHE4 Q8TF40 Q8WTW4 Q8WTX7 Q969R8 Q96A05 Q96EE3 Q96LB4 Q96MD2 Q96S15 Q99437 Q9BVC4 Q9HB90 Q9NQL2 Q9NXC5 Q9P0V3 Q9P278 Q9UHA4 Q9UI12 Q9Y2Q5 Q9Y5K8 Q9Y664 Q9Y6P5	ATP6A1 ATP6B1 ATP6B2 ATP6C ATP6D ATP6E ATP6E1 ATP6E2 ATP6EL2 ATP6F ATP6G ATP6G1 ATP6G2 ATP6G3 ATP6H ATP6J ATP6L ATP6M ATP6N1C ATP6S14 ATP6V0A3 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E ATP6V0E1 ATP6V0E2 ATP6V0E2L ATP6V1A ATP6V1A1 ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1EL2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATPL BHD BMT2 BOG25 C11orf59 C12orf66 C16orf21 C16orf35 C1orf84 C7orf32 C7orf59 C7orf60 CASTOR1 CASTOR2 CGTHBA D3S1231E DEPDC5 EHB10 FLCN FNIP1 FNIP2 FNIPL FRAP FRAP1 FRAP2 GATSL1 GATSL2 GATSL3 GBL HBXIP Hi95 ITFG2 KIAA0467 KIAA0645 KIAA1303 KIAA1450 KIAA1923 KIAA1961 KICS2 KPTN LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MAPO1 MARE MIOS MLST8 MTOR NG38 NPRL2 NPRL3 PA26 PDRO RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD SAMTOR SEC13 SEC13A SEC13L SEC13L1 SEC13R SEH1 SEH1L SESN1 SESN2 SEST1 SEST2 SH3BP4 SLC38A9 SZT2 TCIRG1 TTP TUSC4 URLC11 VATB VATC VATD VATF VPATPD VPP2 VPP3 WDR24 WDR59 XIP	Homo sapiens (human)
Synthesis of diphthamide-EEF2	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 Diphthamide biosynthesis protein 3 Diphthine methyl ester synthase Diphthine methyltransferase Diphthine--ammonia ligase DnaJ homolog subfamily C member 24 Elongation factor 2	P13639 Q6P3W2 Q7L8W6 Q96FX2 Q9BQC3 Q9BTV6 Q9BZG8 Q9H2P9	ATPBD4 C9orf112 DESR1 DNAJC24 DPH1 DPH2 DPH2L DPH2L1 DPH2L2 DPH3 DPH4 DPH5 DPH6 DPH7 EEF2 EF2 OVCA1 WDR85 ZCSL2 ZCSL3	Homo sapiens (human)
Transport and synthesis of PAPS	Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Adenosine 3'-phospho 5'-phosphosulfate transporter 2 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Sulfate anion transporter 1 Sulfate transporter	O43252 O95340 P50443 Q8TB61 Q9H1N7 Q9H2B4	ATPSK1 ATPSK2 C6orf196 DTD DTDST PAPSS PAPSS1 PAPSS2 PAPST1 PAPST2 SAT1 SLC26A1 SLC26A2 SLC35B2 SLC35B3	Homo sapiens (human)
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	Death domain-associated protein 6 Transcriptional regulator ATRX	P46100 Q9UER7	ATRX BING2 DAP6 DAXX RAD54L XH2	Homo sapiens (human)
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	Death domain-associated protein 6 Transcriptional regulator ATRX	P46100 Q9UER7	ATRX BING2 DAP6 DAXX RAD54L XH2	Homo sapiens (human)
Kinesins	Centromere-associated protein E Chromosome-associated kinesin KIF4A Chromosome-associated kinesin KIF4B Kinesin heavy chain isoform 5A Kinesin light chain 1 Kinesin light chain 2 Kinesin light chain 3 Kinesin light chain 4 Kinesin-1 heavy chain Kinesin-associated protein 3 Kinesin-like protein (Fragment) Kinesin-like protein (Fragment) Kinesin-like protein KIF11 Kinesin-like protein KIF12 Kinesin-like protein KIF13B Kinesin-like protein KIF15 Kinesin-like protein KIF16B Kinesin-like protein KIF18A Kinesin-like protein KIF18B Kinesin-like protein KIF19 Kinesin-like protein KIF1A Kinesin-like protein KIF1B Kinesin-like protein KIF1C Kinesin-like protein KIF20A Kinesin-like protein KIF20B Kinesin-like protein KIF21A Kinesin-like protein KIF21B Kinesin-like protein KIF22 Kinesin-like protein KIF23 Kinesin-like protein KIF25 Kinesin-like protein KIF26A Kinesin-like protein KIF26B Kinesin-like protein KIF27 Kinesin-like protein KIF28P Kinesin-like protein KIF2A Kinesin-like protein KIF2B Kinesin-like protein KIF2C Kinesin-like protein KIF3A Kinesin-like protein KIF3B Kinesin-like protein KIF3C Kinesin-like protein KIF6 Kinesin-like protein KIF9 Kinesin-like protein KIFC1 Kinesin-like protein KIFC2 Rac GTPase-activating protein 1	B7ZC32 O00139 O14782 O15066 O43896 O60333 O75037 O95235 O95239 P33176 P52732 Q02224 Q02241 Q07866 Q12756 Q12840 Q14807 Q2KJY2 Q2TAC6 Q2VIQ3 Q66K46 Q6P597 Q6PKD1 Q6ZMV9 Q7Z4S6 Q86VH2 Q86Y91 Q8N4N8 Q8NI77 Q92845 Q96AC6 Q96FN5 Q96L93 Q96Q89 Q99661 Q9BW19 Q9H0B6 Q9H0H5 Q9HAQ2 Q9NQT8 Q9NS87 Q9NSK0 Q9UIL4 Q9ULI4 Q9Y496	ATSV C20orf23 C2orf20 C6orf102 CENPE EG5 GAKIN HSET KIAA0359 KIAA0449 KIAA0591 KIAA0639 KIAA0706 KIAA1236 KIAA1448 KIAA1478 KIAA1590 KIAA1708 KID KIF11 KIF12 KIF13B KIF15 KIF16B KIF18A KIF18B KIF19 KIF1A KIF1B KIF1C KIF2 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF25 KIF26A KIF26B KIF27 KIF28P KIF2A KIF2B KIF2C KIF3 KIF3A KIF3AP KIF3B KIF3C KIF4 KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF9 KIFAP3 KIFC1 KIFC2 KLC KLC1 KLC2 KLC2L KLC3 KLC4 KLP2 KLP6 KNS KNS1 KNS2 KNSL1 KNSL2 KNSL3 KNSL4 KNSL5 KNSL6 KNSL7 KNSL8 KRMP1 MGCRACGAP MKLP1 MKLP2 MPHOSPH1 NKHC1 RAB6KIFL RACGAP1 SMAP SNX23 TRIP5	Homo sapiens (human)
Josephin domain DUBs	Ataxin-3-like protein Ataxin-3 E3 ubiquitin-protein ligase parkin Josephin-1 Josephin-2 Polyubiquitin-B Polyubiquitin-C Transitional endoplasmic reticulum ATPase UV excision repair protein RAD23 homolog A UV excision repair protein RAD23 homolog B Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O60260 P0CG47 P0CG48 P54252 P54725 P54727 P55072 P62979 P62987 Q15040 Q8TAC2 Q9H3M9	ATX3 ATX3L ATXN3 ATXN3L HEL-220 HEL-S-70 JOSD1 JOSD2 JSPH1 KIAA0063 MJD MJD1 MJDL PARK2 PRKN RAD23A RAD23B RPS27A SCA3 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VCP	Homo sapiens (human)
Tight junction interactions	Claudin-10 Claudin-11 Claudin-12 Claudin-14 Claudin-15 Claudin-16 Claudin-17 Claudin-18 Claudin-19 Claudin-1 Claudin-20 Claudin-22 Claudin-23 Claudin-2 Claudin-3 Claudin-4 Claudin-5 Claudin-6 Claudin-7 Claudin-8 Claudin-9 Envelope small membrane protein InaD-like protein Junctional adhesion molecule A Partitioning defective 3 homolog Partitioning defective 6 homolog alpha Partitioning defective 6 homolog beta Partitioning defective 6 homolog gamma Protein PALS1 Protein crumbs homolog 3 Protein kinase C iota type	O00501 O14493 O15551 O75508 O95471 O95484 O95500 O95832 P0DTC4 P41743 P56746 P56747 P56748 P56749 P56750 P56856 P56880 P57739 P78369 Q8N3R9 Q8N6F1 Q8N7P3 Q8NI35 Q8TEW0 Q96B33 Q9BUF7 Q9BYG4 Q9BYG5 Q9NPB6 Q9Y5I7 Q9Y624	AWAL C7orf1 CEPTRL2 CIPP CLD1 CLDN1 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CPER CPETR1 CPETR2 CPETRL2 CRB3 DXS1179E E F11R INADL JAM1 JCAM MPP5 OSP OTM PALS1 PAR3 PAR3A PAR6A PAR6B PAR6G PARD3 PARD6A PARD6B PARD6G PATJ PCLN1 PRKCI SEMP1 TMVCF WBSCR8	Homo sapiens (human)

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