Signalling to ERK5
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- BMK1
- ERK5
- MAP2K5
- MAPK7
- MEK5
- MKK5
- PRKM7
- PRKMK5
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Homo sapiens (human)
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Signaling by MAPK mutants
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- C11orf81
- DUSP10
- DUSP16
- DUSP6
- DUSP7
- DUSP8
- DUSP9
- ERK2
- KIAA1700
- MAPK1
- MKP3
- MKP4
- MKP5
- MKP7
- PRKM1
- PRKM2
- PYST1
- PYST2
- VH5
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Homo sapiens (human)
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Suppression of autophagy
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- DUSP16
- KIAA1700
- MKP7
- RAB7
- RAB7A
- eis
- sapM
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Homo sapiens (human)
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ERKs are inactivated
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- BMK1
- DUSP3
- DUSP4
- DUSP6
- DUSP7
- ERK1
- ERK2
- ERK5
- MAPK1
- MAPK3
- MAPK7
- MKP2
- MKP3
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5D
- PRKM1
- PRKM2
- PRKM3
- PRKM7
- PYST1
- PYST2
- VH2
- VHR
- VRK3
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Homo sapiens (human)
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Regulation of Apoptosis
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Homo sapiens (human)
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Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3
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Homo sapiens (human)
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Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2
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Homo sapiens (human)
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Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1
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Homo sapiens (human)
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Regulation of IFNG signaling
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- CIS3
- DDXBP1
- HCP
- IFNG
- IFNGR1
- IFNGR2
- IFNGT1
- JAK1
- JAK1A
- JAK1B
- JAK2
- PIAS1
- PTP1B
- PTP1C
- PTP2C
- PTPN1
- PTPN11
- PTPN6
- SHPTP2
- SMT3C
- SMT3H3
- SOCS1
- SOCS3
- SSI1
- SSI3
- SUMO1
- TIP3
- UBL1
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Homo sapiens (human)
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SUMOylation of immune response proteins
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- EIF2AK2
- FIP3
- IKBA
- IKBKE
- IKBKG
- IKKE
- IKKI
- KIAA0151
- LUN
- LYT10
- MAD3
- NEMO
- NFKB2
- NFKB3
- NFKBI
- NFKBIA
- PIAS3
- PIAS4
- PIASG
- PKR
- PRKR
- RELA
- SMT3A
- SMT3C
- SMT3H1
- SMT3H3
- SUMO1
- SUMO3
- TOPORS
- TP53BPL
- UBC9
- UBCE9
- UBE2I
- UBL1
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Homo sapiens (human)
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Downregulation of SMAD2/3:SMAD4 transcriptional activity
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- ADPRT
- ATP1B4
- CTG26
- DFFRX
- DPC4
- ERK1
- ERK2
- FAM
- HDAC1
- KIAA0439
- KIAA1047
- KIAA1113
- MADH2
- MADH3
- MADH4
- MADH7
- MADH8
- MADR2
- MAPK1
- MAPK3
- NCOR1
- NCOR2
- NEDD4L
- NEDL3
- PARP1
- PPM1A
- PPOL
- PPPM1A
- PRKM1
- PRKM2
- PRKM3
- RFG7
- RNF111
- RPD3L1
- RPS27A
- SFT
- SKI
- SKIIP
- SKIL
- SKIP
- SMAD2
- SMAD3
- SMAD4
- SMAD7
- SMURF2
- SNO
- SNW1
- TAZ
- TGIF
- TGIF1
- TGIF2
- TIF1G
- TRIM33
- UBA52
- UBA80
- UBB
- UBC
- UBC5A
- UBC5C
- UBCEP1
- UBCEP2
- UBCH5
- UBCH5A
- UBCH5C
- UBE2D1
- UBE2D3
- USP9
- USP9X
- WWTR1
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Homo sapiens (human)
|
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Negative regulation of MET activity
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- AF1P
- CBL
- CBL2
- CIN85
- CNSA1
- CNSA2
- CNSA3
- DEP1
- EPS15
- HBP
- HGF
- HGS
- HPTA
- HRS
- KIAA0055
- LIG1
- LRIG1
- MET
- PTP1B
- PTPN1
- PTPN2
- PTPRJ
- PTPT
- RNF55
- RPS27A
- SH3D2A
- SH3D2B
- SH3D2C
- SH3GL1
- SH3GL2
- SH3GL3
- SH3KBP1
- STAM
- STAM1
- STAM2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- UBPY
- USP8
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Homo sapiens (human)
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InlB-mediated entry of Listeria monocytogenes into host cell
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- AF1P
- CBL
- CBL2
- CIN85
- CNSA1
- CNSA2
- CNSA3
- EPS15
- HBP
- HGS
- HRS
- MET
- RNF55
- RPS27A
- SH3D2A
- SH3D2B
- SH3D2C
- SH3GL1
- SH3GL2
- SH3GL3
- SH3KBP1
- STAM
- STAM1
- STAM2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- inlB
|
Homo sapiens (human)
|
|
Negative regulation of FGFR2 signaling
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- CBL
- CBL2
- ERK1
- ERK2
- FGF1
- FGF10
- FGF16
- FGF18
- FGF2
- FGF20
- FGF22
- FGF23
- FGF3
- FGF4
- FGF6
- FGF7
- FGF9
- FGFA
- FGFB
- FRS2
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- INT2
- KGF
- KS3
- MAPK1
- MAPK3
- PRKM1
- PRKM2
- PRKM3
- PTP2C
- PTPN11
- RNF55
- RPS27A
- SHPTP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
Homo sapiens (human)
|
|
Negative regulation of FGFR3 signaling
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- CBL
- CBL2
- ERK1
- ERK2
- FGF1
- FGF16
- FGF18
- FGF2
- FGF20
- FGF23
- FGF4
- FGF9
- FGFA
- FGFB
- FRS2
- HST
- HSTF1
- HYPF
- KS3
- MAPK1
- MAPK3
- PRKM1
- PRKM2
- PRKM3
- PTP2C
- PTPN11
- RNF55
- RPS27A
- SHPTP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
Homo sapiens (human)
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Negative regulation of FLT3
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|
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- ABL2
- ABLL
- ARG
- C20orf156
- CBL
- CBL2
- CD135
- CIS2
- CIS4
- CSK
- DEP1
- FLK2
- FLT3
- FLT3LG
- LNK
- PTPRJ
- RNF55
- RPS27A
- SH2B3
- SLA
- SLA2
- SLAP
- SLAP1
- SLAP2
- SOCS2
- SOCS4
- SOCS6
- SSI2
- STATI2
- STK1
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
Homo sapiens (human)
|
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FLT3 signaling by CBL mutants
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|
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- CBL
- CBL2
- CD135
- FLK2
- FLT3
- FLT3LG
- RNF55
- RPS27A
- STK1
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
Homo sapiens (human)
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TGF-beta receptor signaling activates SMADs
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- ALK5
- C14orf141
- CBL
- CBL2
- DPC4
- FKBP1
- FKBP12
- FKBP1A
- FNRB
- FUR
- FURIN
- GP3A
- ITGA8
- ITGAV
- ITGB1
- ITGB3
- ITGB5
- ITGB6
- ITGB8
- LTBP1
- LTBP2
- LTBP3
- LTBP4
- MADH2
- MADH3
- MADH4
- MADR2
- MDF2
- MSK12
- MSK8
- NEDD8
- PACE
- PCSK3
- RNF55
- SKR4
- SMAD2
- SMAD3
- SMAD4
- TGFB
- TGFB1
- TGFB2
- TGFB3
- TGFBR1
- TGFBR2
- TGFBR3
- UBC12
- UBE2M
- VNRA
- VTNR
|
Homo sapiens (human)
|
|
Interleukin-6 signaling
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- APRF
- CBL
- CBL2
- CIS3
- IFNB2
- IL6
- IL6R
- IL6ST
- JAK1
- JAK1A
- JAK1B
- JAK2
- PTP2C
- PTPN11
- RNF55
- SHPTP2
- SOCS3
- SSI3
- STAT1
- STAT3
- TYK2
|
Homo sapiens (human)
|
|
Spry regulation of FGF signaling
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|
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- BRAF
- BRAF1
- CBL
- CBL2
- ERK1
- ERK2
- MAPK1
- MAPK3
- MKNK1
- MNK1
- PPP2CA
- PPP2CB
- PPP2R1A
- PRKM1
- PRKM2
- PRKM3
- PTP2C
- PTPN11
- RAFB1
- RNF55
- RPS27A
- SHPTP2
- SPRY2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
Homo sapiens (human)
|
|
Regulation of KIT signaling
|
|
|
- APS
- CBL
- CBL2
- CIS4
- FYN
- HCP
- JTK8
- KIT
- LCK
- LNK
- LYN
- PKCA
- PRKACA
- PRKCA
- PTP1C
- PTPN6
- RNF55
- SCFR
- SH2B2
- SH2B3
- SOCS1
- SOCS4
- SOCS6
- SOS1
- SSI1
- TIP3
- YES
- YES1
|
Homo sapiens (human)
|
|
Regulation of innate immune responses to cytosolic DNA
|
|
|
- ABS
- C20orf183
- DDX41
- DLM1
- DTX4
- ERIS
- HT2A
- IRF3
- KIAA0937
- MITA
- NAK
- NALP4
- NLRP4
- PAN2
- PYPAF4
- RNF109
- RNF155
- RNF81
- RNH2
- RO52
- RPS27A
- SSA1
- STING
- STING1
- TBK1
- TMEM173
- TRIM21
- TRIM32
- TRIM56
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- ZBP1
|
Homo sapiens (human)
|
|
IRF3 mediated activation of type 1 IFN
|
|
|
- C20orf183
- DLM1
- DTX4
- IRF3
- KIAA0937
- NAK
- NALP4
- NLRP4
- PAN2
- PYPAF4
- RNF155
- RNH2
- TBK1
- ZBP1
|
Homo sapiens (human)
|
|
Downregulation of ERBB4 signaling
|
|
|
- ITCH
- KIAA0093
- NEDD4
- NEDD4-1
- RPF1
- RPS27A
- SRC
- SRC1
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- WWP1
|
Homo sapiens (human)
|
|
LXRs regulate gene expression to limit cholesterol uptake
|
|
|
- BZF1
- IDOL
- LXRA
- LXRB
- MYLIP
- NER
- NR1H2
- NR1H3
- NR2B1
- NR2B2
- RXRA
- RXRB
- UNR
|
Homo sapiens (human)
|
|