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obesity
Summary
- Definition
- An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
- Super Class
- overnutrition
External Links
- Disease Ontology
- DOID:9970
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- MGI genotype (from TogoID)
-
- 3766125
- 3821619
- 3821616
- 3817475
- 3799316
- 3784993
- 3784991
- 3773447
- 3772367
- 3822317
- 3766122
- 3721145
- 3715252
- 3694548
- 3689720
- 3664551
- 3664276
- 3655835
- 5515728
- 7545554
- 7545550
- 7545546
- 6273993
- 5828524
- 5766495
- 5763310
- 5763241
- 3655832
- 5447549
- 5300906
- 3850836
- 3847120
- 3840234
- 3832410
- 3822318
- 3033164
- 3511746
- 3055585
- 3055584
- 3053798
- 3041643
- 3036853
- 3036852
- 3033165
- 3511747
- 2681522
- 2680503
- 2669229
- 2663736
- 2654708
- 2653295
- 2651886
- 2388265
- 3589409
- 3655811
- 3639781
- 3639355
- 3639354
- 3629805
- 3623749
- 3620067
- 3611807
- 2174793
- 3586756
- 3582615
- 3580003
- 3579026
- 3577766
- 3526863
- 3511748
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 5468 | PPARG | peroxisome proliferator activated receptor gamma | |
| 6513 | SLC2A1 | solute carrier family 2 member 1 | |
| 6531 | SLC6A3 | solute carrier family 6 member 3 | |
| 6774 | STAT3 | signal transducer and activator of transcription 3 | |
| 7351 | UCP2 | uncoupling protein 2 | |
| 7352 | UCP3 | uncoupling protein 3 | |
| 7480 | WNT10B | Wnt family member 10B | |
| 8202 | NCOA3 | nuclear receptor coactivator 3 | |
| 9021 | SOCS3 | suppressor of cytokine signaling 3 | |
| 9672 | SDC3 | syndecan 3 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 12876 | Cpe | carboxypeptidase E | |
| 14738 | Gpr12 | G-protein coupled receptor 12 | |
| 14917 | Gucy2c | guanylate cyclase 2c | |
| 16846 | Lep | leptin | |
| 16847 | Lepr | leptin receptor | |
| 17201 | Mc3r | melanocortin 3 receptor | |
| 17202 | Mc4r | melanocortin 4 receptor | |
| 17977 | Ncoa1 | nuclear receptor coactivator 1 | |
| 18166 | Npy1r | neuropeptide Y receptor Y1 | |
| 18548 | Pcsk1 | proprotein convertase subtilisin/kexin type 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 25149 | Esr2 | estrogen receptor 2 | |
| 25248 | Cnr1 | cannabinoid receptor 1 | |
| 25467 | Irs1 | insulin receptor substrate 1 | |
| 25601 | Oprm1 | opioid receptor, mu 1 | |
| 25608 | Lep | leptin | |
| 25635 | Mc4r | melanocortin 4 receptor | |
| 29260 | Tlr4 | toll-like receptor 4 | |
| 29473 | Aoc3 | amine oxidase, copper containing 3 | |
| 29708 | Gabra6 | gamma-aminobutyric acid type A receptor subunit alpha6 | |
| 83516 | Ppargc1a | PPARG coactivator 1 alpha |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| Q9C0B1 | Alpha-ketoglutarate-dependent dioxygenase FTO | |
| Q9H221 | ATP-binding cassette sub-family G member 8 | |
| Q9HC96 | Calpain-10 | |
| Q9P0J1 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial | |
| Q9UN76 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) | |
| Q9Y6Q9 | Nuclear receptor coactivator 3 |
| UniProt ID | Protein Name | Source |
|---|---|---|
| P01193 | Pro-opiomelanocortin | |
| P33033 | Melanocortin receptor 3 | |
| P35412 | G-protein coupled receptor 12 | |
| P56450 | Melanocortin receptor 4 | |
| P60879 | Synaptosomal-associated protein 25 | |
| P63239 | Neuroendocrine convertase 1 | |
| P70365 | Nuclear receptor coactivator 1 | |
| Q00493 | Carboxypeptidase E | |
| Q03288 | Agouti-signaling protein | |
| Q04573 | Neuropeptide Y receptor type 1 |
| UniProt ID | Protein Name | Source |
|---|---|---|
| O08590 | Amine oxidase [copper-containing] 3 | |
| P01026 | Complement C3 | |
| P01194 | Pro-opiomelanocortin | |
| P05708 | Hexokinase-1 | |
| P06211 | Estrogen receptor | |
| P06866 | Haptoglobin | |
| P07867 | Hepatic triacylglycerol lipase | |
| P10719 | ATP synthase subunit beta, mitochondrial | |
| P16232 | 11-beta-hydroxysteroid dehydrogenase 1 | |
| P18292 | Prothrombin |
| UniProt ID | Protein Name | Source |
|---|---|---|
| O97394 | Protein sidekick | |
| P09615 | Protein wingless | |
| P27091 | Protein 60A | |
| P33450 | Cadherin-related tumor suppressor | |
| P54360 | Extracellular serine/threonine protein kinase four-jointed | |
| P83094 | Stromal interaction molecule homolog | |
| Q24292 | Protein dachsous | |
| Q8ITC9 | Pyrokinin-1 receptor | |
| Q9V4A7 | Plexin-B |
| UniProt ID | Protein Name | Source |
|---|---|---|
| O62106 | Eukaryotic translation initiation factor 6 | |
| P13508 | Protein glp-1 | |
| Q19791 | A disintegrin and metalloproteinase with thrombospondin motifs gon-1 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0010982 | Polygenic inheritance |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0012340 | Decreased resting energy expenditure |
| HP:0001513 | Obesity |
