XAV939 stabilizes AXIN
|
|
|
- PARP5A
- PARP5B
- PARPL
- TANK2
- TIN1
- TINF1
- TNKL
- TNKS
- TNKS1
- TNKS2
|
|
Myoclonic epilepsy of Lafora
|
|
|
- EPM2A
- EPM2B
- GYG
- GYG1
- GYS
- GYS1
- NHLRC1
- PPP1R3C
- PPP1R5
- RPS27A
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Pentose phosphate pathway
|
|
|
- CARKL
- DERA
- G6PD
- PGD
- PGDH
- PGLS
- PGM2
- RBKS
- RBSK
- RPE
- RPEL1
- RPI
- RPIA
- SHPK
- TAL
- TALDO
- TALDO1
- TALDOR
- TKT
|
|
Defective PAPSS2 causes SEMD-PA
|
|
|
|
|
Defective ABCB11 causes PFIC2 and BRIC2
|
|
|
|
|
Mitochondrial tRNA aminoacylation
|
- Alanine--tRNA ligase, mitochondrial
- Asparaginyl-tRNA synthetase
- Aspartate--tRNA ligase, mitochondrial
- Glutamine--tRNA ligase
- Glycine--tRNA ligase
- Histidine--tRNA ligase, mitochondrial
- Inorganic pyrophosphatase 2, mitochondrial
- Isoleucine--tRNA ligase, mitochondrial
- Leucine--tRNA ligase, mitochondrial
- Lysine--tRNA ligase
- Methionine--tRNA ligase, mitochondrial
- Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial
- Phenylalanine--tRNA ligase, mitochondrial
- Probable arginine--tRNA ligase, mitochondrial
- Probable cysteine--tRNA ligase, mitochondrial
- Probable proline--tRNA ligase, mitochondrial
- Serine--tRNA ligase, mitochondrial
- Threonine--tRNA ligase, mitochondrial
- Tryptophan--tRNA ligase, mitochondrial
- Tyrosine--tRNA ligase, mitochondrial
- Valine--tRNA ligase, mitochondrial
|
|
- AARS2
- AARSL
- CARS2
- DARS2
- EARS2
- FARS1
- FARS2
- GARS
- GARS1
- HARS2
- HARSL
- HARSR
- HO3
- IARS2
- KARS
- KARS1
- KIAA0028
- KIAA0070
- KIAA1270
- KIAA1885
- KIAA1970
- LARS2
- MARS2
- NARS2
- PARS2
- PPA2
- QARS
- QARS1
- RARS2
- RARSL
- SARS2
- SARSM
- TARS2
- TARSL1
- VARS2
- VARS2L
- VARSL
- WARS2
- YARS2
|
|
PI Metabolism
|
|
|
- TIPE3
- TNFAIP8
- TNFAIP8L1
- TNFAIP8L2
- TNFAIP8L3
|
|
Molecules associated with elastic fibres
|
|
|
- BMP10
- BMP14
- BMP2
- BMP2A
- BMP2B
- BMP4
- BMP7
- C14orf141
- CDMP1
- DANCE
- DVR4
- EFEMP1
- EFEMP2
- FBLN1
- FBLN2
- FBLN3
- FBLN4
- FBLN5
- FBNL
- FNRB
- GDF5
- GP3A
- ITGA8
- ITGAV
- ITGB1
- ITGB3
- ITGB5
- ITGB6
- ITGB8
- LTBP1
- LTBP2
- LTBP3
- LTBP4
- MAGP1
- MAGP2
- MDF2
- MFAP2
- MFAP3
- MFAP4
- MFAP5
- MSK12
- MSK8
- OP1
- TGFB
- TGFB1
- TGFB2
- TGFB3
- VNRA
- VTN
- VTNR
|
|
Molybdenum cofactor biosynthesis
|
|
|
- GPH
- GPHN
- KIAA1385
- MCBPE
- MOCO1
- MOCOS
- MOCS2
- MOCS3
- UBA4
|
|
TNF signaling
|
|
|
- ADAM17
- BAG4
- CSVP
- RIP
- RIP1
- RIPK1
- SODD
- TACE
- TNF
- TNFA
- TNFAR
- TNFR1
- TNFRSF1A
- TNFSF2
- TRADD
- TRAF2
- TRAP3
|
|
Surfactant metabolism
|
|
|
- ABC3
- ABCA3
- ADA2
- ADGF
- ADGRF5
- ADORA2
- ADORA2A
- ADORA2B
- ADRA2A
- ADRA2C
- ADRA2L2
- ADRA2R
- ADRA2RL2
- ADRAR
- BR22
- CCDC59
- CECR1
- CKAP4
- COLEC4
- COLEC5
- COLEC7
- CPSB
- CSF2R
- CSF2RA
- CSF2RB
- CSF2RY
- CTSH
- DMBT1
- GATA6
- GP340
- GPR116
- IDGFL
- IL3RB
- IL5RB
- KIAA0758
- LMCD1
- NAP1
- NAPA
- NAPSA
- NPT2
- P2RU1
- P2RY2
- PGA3
- PGA4
- PGA5
- PSAP
- PSPD
- REAM
- REC
- SFTA3
- SFTP1
- SFTP2
- SFTP3
- SFTP4
- SFTPA
- SFTPA1
- SFTPA1B
- SFTPA2
- SFTPA2B
- SFTPB
- SFTPC
- SFTPD
- SFTPH
- SLC17A2
- SLC34A1
- SLC34A2
- TAP26
- TTF1
- ZDHHC2
- ZNF372
|
|
Type II Na+/Pi cotransporters
|
|
|
- NPT2
- NPT2C
- NPTIIC
- SLC17A2
- SLC34A1
- SLC34A2
- SLC34A3
|
|
Defective SLC34A2 causes PALM
|
|
|
|
|
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
|
|
|
|
|
ATF4 activates genes in response to endoplasmic reticulum stress
|
|
|
- ASNS
- ATF3
- ATF4
- ATF6
- CCL2
- CEBPB
- CEBPG
- CHOP
- CHOP10
- CML28
- CREB2
- CSL4
- CXCL8
- DAN
- DCP2
- DDIT3
- DIS3
- EXOSC1
- EXOSC2
- EXOSC3
- EXOSC4
- EXOSC5
- EXOSC6
- EXOSC7
- EXOSC8
- EXOSC9
- FUBP2
- GADD153
- HAP3
- HERP
- HERPUD1
- IBP1
- IGFBP1
- IL8
- KHSRP
- KIAA0025
- KIAA0116
- KIAA1008
- MCP1
- MIF1
- MTR3
- NFYA
- NFYB
- NFYC
- NUDT20
- OIP2
- PARN
- PMSCL1
- RRP4
- RRP40
- RRP41
- RRP42
- RRP43
- RRP44
- RRP46
- SCYA2
- SKI6
- TCF5
- TS11
- TXREB
|
|
KSRP (KHSRP) binds and destabilizes mRNA
|
|
|
- AKT1
- CML28
- CSBP
- CSBP1
- CSBP2
- CSL4
- CSPB1
- DAN
- DCP2
- DIS3
- EXOSC1
- EXOSC2
- EXOSC3
- EXOSC4
- EXOSC5
- EXOSC6
- EXOSC7
- EXOSC8
- EXOSC9
- FUBP2
- KHSRP
- KIAA0116
- KIAA1008
- MAPK11
- MAPK14
- MTR3
- MXI2
- NUDT20
- OIP2
- PARN
- PKB
- PMSCL1
- PRKM11
- RAC
- RRP4
- RRP40
- RRP41
- RRP42
- RRP43
- RRP44
- RRP46
- SAPK2
- SAPK2A
- SAPK2B
- SKI6
- YWHAZ
|
|
Depolymerization of the Nuclear Lamina
|
|
|
- C16orf69
- CCNB
- CCNB1
- CDC2
- CDC28A
- CDK1
- CDKN1
- CNEP1R1
- CTDNEP1
- DULLARD
- EDMD
- EMD
- KIAA0188
- KIAA0249
- LEMD2
- LEMD3
- LIPN3L
- LMN2
- LMNB
- LMNB1
- LPIN1
- LPIN2
- LPIN3
- MAN1
- P34CDC2
- PKCA
- PKCB
- PRKACA
- PRKCA
- PRKCB
- PRKCB1
- STA
- TMEM188
|
|
HDL assembly
|
|
|
- A2M
- ABC1
- ABCA1
- APOA1
- CERP
- CPAMD5
- KIAA1292
- PKACA
- PRKACA
- PRKACB
- PRKACG
- ZDHHC8
- ZDHHCL1
- ZNF378
|
|
Defective ABCA1 causes TGD
|
|
|
|
|
Defective SLC2A10 causes arterial tortuosity syndrome (ATS)
|
|
|
|
|
Nicotinate metabolism
|
|
|
- BST1
- C1orf15
- C5orf33
- C9orf95
- CD38
- ITGB1BP3
- KIAA0479
- MNADK
- NADK
- NADK2
- NADKD1
- NADSYN1
- NMNAT
- NMNAT1
- NMNAT2
- NMNAT3
- NMRK1
- NMRK2
- NRK1
- NRK2
- NT5
- NT5E
- NTE
- QPRT
|
|
Pyruvate metabolism
|
|
|
- AAT1
- BRP44
- BRP44L
- C16orf36
- FAHD1
- GLO1
- GPT
- GPT1
- LDH3
- LDHA
- LDHAL6
- LDHAL6A
- LDHAL6B
- LDHB
- LDHC
- LDHL
- LDHL2
- LDHX
- ME1
- ME2
- ME3
- MPC1
- MPC1L
- MPC2
- PC
- VDAC
- VDAC1
- YISKL
|
|
Sulfide oxidation to sulfate
|
|
|
- DIC
- ETHE1
- HSCO
- KAT
- SLC25A10
- SQOR
- SQRDL
- SUOX
- TST
- TSTD1
|
|
Activation of the TFAP2 (AP-2) family of transcription factors
|
|
|
- AP2TF
- CBP
- CITED1
- CITED2
- CITED4
- CREBBP
- EP300
- FOR
- GAS41
- MRG1
- MRG2
- MSG1
- P300
- SDR41C1
- TFAP2
- TFAP2A
- TFAP2B
- TFAP2BL1
- TFAP2C
- TFAP2D
- TFAP2E
- WOX1
- WWOX
- YEATS4
|
|
Role of second messengers in netrin-1 signaling
|
|
|
- DCC
- IGDCC1
- NTN1
- NTN1L
- PITPN
- PITPNA
- PLC1
- PLCG1
- TRP1
- TRP3
- TRP5
- TRP6
- TRP7
- TRPC1
- TRPC3
- TRPC4
- TRPC5
- TRPC6
- TRPC7
|
|