GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen, GlyConnect, GlycoProtDB and The O-GlcNAc Database. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Source	Last Updated
GlyConnect	March 24, 2025
GlycoProtDB	December 4, 2018
GlyGen	October 30, 2024
The O-GlcNAc Database	January 30, 2025
UniProt	February 20, 2025

Displaying entries **1 - 25** of **206** in total

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UniProt ID	Protein Name	Gene Symbol	Organism	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	GlyTouCan ID	Disease Ontology	Disease Ontology ID	Gene Ontology ▲	Gene Ontology ID
Q15554	Telomeric repeat-binding factor 2	TERF2 TRBF2 TRF2	Homo sapiens (human)	9606	2	2	G28541PG G50713DU			G-rich strand telomeric DNA binding RNA-templated DNA biosynthetic process axon axonal transport of messenger ribonucleoprotein complex cellular senescence chromosome, telomeric region double-stranded telomeric DNA binding enzyme binding in utero embryonic development male germ cell nucleus negative regulation of beta-galactosidase activity negative regulation of cellular senescence negative regulation of exonuclease activity negative regulation of gene expression negative regulation of t-circle formation negative regulation of telomere capping negative regulation of telomere maintenance via recombination negative regulation of telomere maintenance via semi-conservative replication negative regulation of telomere maintenance via telomerase negative regulation of telomere maintenance via telomere lengthening negative regulation of telomere maintenance negative regulation of telomere single strand break repair negative regulation of telomeric D-loop disassembly nuclear body nuclear telomere cap complex nucleoplasm nucleus positive regulation of gene expression positive regulation of nitric-oxide synthase activity positive regulation of telomere maintenance protection from non-homologous end joining at telomere protein homodimerization activity protein localization to chromosome, telomeric region protein-containing complex binding regulation of telomere maintenance via telomerase regulation of telomere maintenance shelterin complex telomere capping telomere maintenance telomeric D-loop disassembly telomeric DNA binding telomeric loop formation	GO:0000723 GO:0000781 GO:0000783 GO:0001673 GO:0001701 GO:0003691 GO:0005634 GO:0005654 GO:0006278 GO:0010628 GO:0010629 GO:0016233 GO:0016604 GO:0019899 GO:0030424 GO:0031627 GO:0031848 GO:0032204 GO:0032205 GO:0032206 GO:0032208 GO:0032210 GO:0032211 GO:0032214 GO:0042162 GO:0042803 GO:0044877 GO:0051000 GO:0061820 GO:0070187 GO:0070198 GO:0090398 GO:0098505 GO:0099088 GO:1903770 GO:1903824 GO:1904354 GO:1904357 GO:1904430 GO:1905778 GO:1905839 GO:2000773
P51569	Alpha-galactosidase A	Ags Gla	Mus musculus (house mouse)	10090	3	0				Golgi apparatus alpha-galactosidase activity aorta development catalytic activity cytoplasm extracellular region extracellular space glycosylceramide catabolic process hydrolase activity lysosome membrane negative regulation of nitric oxide biosynthetic process negative regulation of nitric-oxide synthase activity oligosaccharide metabolic process protein homodimerization activity signaling receptor binding	GO:0003824 GO:0004557 GO:0005102 GO:0005576 GO:0005615 GO:0005737 GO:0005764 GO:0005794 GO:0009311 GO:0016020 GO:0016787 GO:0035904 GO:0042803 GO:0045019 GO:0046477 GO:0051001
P06280	Alpha-galactosidase A	GLA	Homo sapiens (human)	9606	3	43	G00406II G00912UN G01937VC G05724UK G06110VR G06247RL G11870QZ G12313PD G14669DU G15169WU G23294PN G23719VF G27058EU G28681TP G29184RN G31852PQ G34989PA G37412TK G39188ZX G41247ZX G43669FQ G45395BF G46503DX G47012YE G47644PP G48414YA G50282JC G62765YT G62894KT G70101JE G70232NH G72291OX G74724QE G75983OB G76417NN G80920RR G82463GQ G83460ZZ G90382BL G90575OW G92275SC G95995BI G96091TT	Fabry disease	DOID:14499	Golgi apparatus alpha-galactosidase activity azurophil granule lumen catalytic activity cytoplasm extracellular exosome extracellular region galactoside binding glycoside catabolic process glycosphingolipid catabolic process glycosylceramide catabolic process hydrolase activity lipid storage lysosomal lumen lysosome membrane negative regulation of nitric oxide biosynthetic process negative regulation of nitric-oxide synthase activity oligosaccharide metabolic process platelet aggregation protein homodimerization activity regulation of axon diameter regulation of locomotion involved in locomotory behavior signaling receptor binding sleep	GO:0003824 GO:0004557 GO:0005102 GO:0005576 GO:0005737 GO:0005764 GO:0005794 GO:0009311 GO:0016020 GO:0016139 GO:0016787 GO:0016936 GO:0019915 GO:0030431 GO:0031133 GO:0035578 GO:0042803 GO:0043202 GO:0045019 GO:0046477 GO:0046479 GO:0051001 GO:0070062 GO:0070527 GO:0090325
Q8BGZ6	Alpha-galactosidase	Gla	Mus musculus (house mouse)	10090	2	0		Fabry disease	DOID:14499	Golgi apparatus alpha-galactosidase activity extracellular region galactoside binding glycosphingolipid catabolic process lipid storage lysosome membrane oligosaccharide metabolic process platelet aggregation protein homodimerization activity regulation of axon diameter regulation of locomotion involved in locomotory behavior signaling receptor binding sleep	GO:0004557 GO:0005102 GO:0005576 GO:0005764 GO:0005794 GO:0009311 GO:0016020 GO:0016936 GO:0019915 GO:0030431 GO:0031133 GO:0042803 GO:0046479 GO:0070527 GO:0090325
P16278	Beta-galactosidase	ELNR1 GLB1	Homo sapiens (human)	9606	7	81	G00912UN G01485JJ G01650EU G02815KT G02886BB G05724UK G06110VR G06247RL G07246CJ G08918WF G10773YW G11115RO G11314AS G11870QZ G11911BT G15664MX G20210JR G23294PN G23719VF G23984SE G25079LO G27915IV G28465XX G28541PG G28681TP G29299MO G30248BL G31852PQ G31986NC G34029GR G34989PA G35029YA G36442WJ G36512SK G37399XV G37412TK G37995HC G39188ZX G39446WN G40574BA G40834TG G41071NU G41247ZX G42124LM G43669FQ G44753VC G45395BF G47644PP G47950XN G49018RC G50282JC G51640FO G53075ES G56625RB G59324HL G62765YT G63041LO G66621EA G70223PD G70232NH G70441OD G72291OX G72735IY G73968GN G74724QE G80920RR G83460ZZ G83633GK G84225JN G86182NS G87661QW G90575OW G90659AW G92050GC G92135MA G92275SC G92406TI G95177YH G95865ZB G96091TT G98611JV	GM1 gangliosidosis type 1 GM1 gangliosidosis type 2 GM1 gangliosidosis type 3 GM1 gangliosidosis mucopolysaccharidosis IV mucopolysaccharidosis IVA mucopolysaccharidosis type IVB	DOID:0080489 DOID:0080501 DOID:0080502 DOID:0111391 DOID:0111392 DOID:12804 DOID:3322	Golgi apparatus azurophil granule lumen beta-galactosidase activity carbohydrate metabolic process cytoplasm extracellular exosome extracellular region ficolin-1-rich granule lumen galactose catabolic process galactoside binding ganglioside catabolic process glycoprotein catabolic process glycosphingolipid catabolic process heparan sulfate proteoglycan catabolic process intracellular membrane-bounded organelle keratan sulfate catabolic process lysosomal lumen lysosome membrane perinuclear region of cytoplasm protein homodimerization activity response to Thyroglobulin triiodothyronine response to cortisone vacuole	GO:0004565 GO:0005576 GO:0005737 GO:0005764 GO:0005773 GO:0005794 GO:0005975 GO:0006516 GO:0006689 GO:0016020 GO:0016936 GO:0019388 GO:0030200 GO:0035578 GO:0042340 GO:0042803 GO:0043202 GO:0043231 GO:0046479 GO:0048471 GO:0051413 GO:0070062 GO:1904016 GO:1904813
P23780	Beta-galactosidase	Bgl Glb-1 Glb1	Mus musculus (house mouse)	10090	8	0		GM1 gangliosidosis	DOID:3322	Golgi apparatus beta-galactosidase activity cytoplasm extracellular space galactose catabolic process galactoside binding ganglioside catabolic process glycoprotein catabolic process hydrolase activity keratan sulfate catabolic process lysosome membrane protein homodimerization activity response to Thyroglobulin triiodothyronine response to cortisone	GO:0004565 GO:0005615 GO:0005737 GO:0005764 GO:0005794 GO:0006516 GO:0006689 GO:0016020 GO:0016787 GO:0016936 GO:0019388 GO:0042340 GO:0042803 GO:0051413 GO:1904016
Q9TRY9	Beta-galactosidase	GLB1	Canis lupus familiaris (dog)	9615	5	0				Golgi apparatus beta-galactosidase activity extracellular space galactose catabolic process ganglioside catabolic process glycoprotein catabolic process keratan sulfate catabolic process lysosome membrane protein homodimerization activity vacuole	GO:0004565 GO:0005615 GO:0005764 GO:0005773 GO:0005794 GO:0006516 GO:0006689 GO:0016020 GO:0019388 GO:0042340 GO:0042803
Q3TAW7	Beta-galactosidase	Glb1	Mus musculus (house mouse)	10090	4	0				Golgi apparatus beta-galactosidase activity galactose catabolic process galactoside binding protein homodimerization activity response to Thyroglobulin triiodothyronine response to cortisone	GO:0004565 GO:0005794 GO:0016936 GO:0019388 GO:0042803 GO:0051413 GO:1904016
P07602	Prosaposin	GLBA PSAP SAP1	Homo sapiens (human)	9606	23	297	G00395TQ G00406II G00912UN G00986YT G01485JJ G01650EU G02815KT G02886BB G03216SJ G03930BU G04483SK G04657PL G04744XB G05049YU G05724UK G05962QB G06110VR G06247RL G07246CJ G07695ZT G07755XJ G08146BT G08290VR G08293MJ G08609CW G08918WF G09724ZC G10256JP G10756ZZ G10773YW G10819WX G11254FL G11314AS G11629QQ G11870QZ G11911BT G11994QC G12313PD G12398HZ G13131HA G14260UH G14669DU G14972EH G14994KB G15169WU G15407YE G15664MX G16125XL G17208MA G18183SM G18647XP G18938DW G20030CU G20312EM G20425TQ G20528HD G20956ZV G22310AV G22355FZ G22573RC G22625SJ G22768VO G23432EQ G23453IV G23719VF G23863VK G23984SE G25079LO G25381UC G25418HZ G25451PN G25637MV G26145IL G27058EU G27126ED G27622TD G27915IV G27947YN G28347RJ G28541PG G28663KH G28681TP G29299MO G29545VG G29857RC G29880MM G29905OR G30248BL G30521DU G30633FJ G30970QQ G31685JQ G31852PQ G31936TA G31986NC G32152BH G32550BI G32788FZ G33609NS G33734YD G34527RW G34617SM G34989PA G35029YA G35253PZ G35541EV G36191CD G36379GD G36442WJ G37399XV G37412TK G37509XX G37881RL G37995HC G39188ZX G39213VZ G39446WN G39602UU G39619TI G40574BA G40834TG G40926MX G41071NU G41247ZX G41840AI G42124LM G42264OV G42666HT G42679AH G43223CG G43299SD G43664YB G43669FQ G43734MM G44753VC G45036WQ G45187EI G45359RY G45395BF G45495MK G45504EY G46503DX G46524LG G46691LC G47012YE G47448YK G47518TP G47644PP G47950XN G48414YA G48584BU G49018RC G49108TO G49755GI G49874UX G50045TK G50282JC G50856PC G51640FO G52428MJ G52890YB G53075ES G54612UD G54702KT G55220VL G55383ZG G56269EA G56784JY G57317CE G57321FI G57776ZS G57776ZU G57888GL G58087IP G59471TH G59626AS G59924QI G60145BJ G60834IK G61207RZ G61256FT G61330YQ G61334IA G61792ET G61884GF G62765YT G62894KT G63041LO G63136LV G63628AV G63889NK G64394MX G64409MC G64481DJ G64527OM G64581RP G65019XG G65092SV G66538GV G66937TJ G67031OU G67164EE G68490OW G69411IG G69521XL G69834CE G70101JE G70223PD G70232NH G70441OD G70619PT G70822IO G70888PK G71838YU G72291OX G72667IM G72735IY G72747WU G72787SB G72791KH G72797UR G74724QE G75607BQ G75983OB G76295SF G76417NN G77547TA G77582RK G78059CC G78649WQ G79286RS G79666IR G79809MM G80075MS G80223IX G80333GO G80479JV G80858MF G80920RR G80966KZ G81198YO G81263BG G81295CK G81397LO G81637OR G82348BZ G82443XX G82463GQ G83006TR G83229XP G83460ZZ G83633GK G83646BJ G84225JN G84349RE G84452RH G84820NF G85041WE G85269DF G85282JO G85554PZ G86182NS G86357DX G86795LJ G86880BF G87051GH G87123QX G87389XI G87399DK G87661QW G88374WZ G88891KO G89045VA G89098OM G89993FE G90093AU G90382BL G90575OW G90659AW G90734RJ G91473PK G91636VS G92050GC G92135MA G92275SC G92406TI G93500PH G93718GY G94470IW G94854LT G95177YH G95865ZB G95977AE G96091TT G96577RX G96771UL G98140IX	atypical Gaucher's disease due to saposin c deficiency combined saposin deficiency late onset Parkinson's disease metachromatic leukodystrophy	DOID:0060892 DOID:0110961 DOID:0111330 DOID:10581	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway azurophil granule membrane collagen-containing extracellular matrix enzyme activator activity epithelial cell differentiation involved in prostate gland development extracellular exosome extracellular region extracellular space ganglioside GM1 binding ganglioside GM1 transport to membrane ganglioside GM2 binding ganglioside GM3 binding ganglioside GP1c binding ganglioside GT1b binding identical protein binding intracellular membrane-bounded organelle late endosome lysosomal lumen lysosomal membrane lysosomal transport lysosome phospholipid binding plasma membrane positive regulation of beta-galactosidase activity prostate gland growth protease binding protein homodimerization activity regulation of autophagy regulation of lipid metabolic process scaffold protein binding sphingolipid metabolic process	GO:0002020 GO:0005543 GO:0005576 GO:0005615 GO:0005764 GO:0005765 GO:0005770 GO:0005886 GO:0006665 GO:0007041 GO:0007193 GO:0008047 GO:0010506 GO:0019216 GO:0035577 GO:0042802 GO:0042803 GO:0043202 GO:0043231 GO:0060736 GO:0060742 GO:0062023 GO:0070062 GO:0097110 GO:1903771 GO:1905572 GO:1905573 GO:1905574 GO:1905575 GO:1905576 GO:1905577
P17050	Alpha-N-acetylgalactosaminidase	NAGA	Homo sapiens (human)	9606	5	94	G00155YT G00406II G01543ZX G02815KT G03005MJ G03275SD G03382KH G03842KQ G05724UK G05808PZ G06110VR G06356OH G06885ZB G07617FP G10486CT G11629QQ G12313PD G12849CJ G14389GM G14669DU G14889BN G15169WU G16828VN G17689DH G20210JR G20425TQ G20512LK G22310AV G22768VO G23863VK G23984SE G25637MV G29857RC G29880MM G31852PQ G33282QL G34617SM G36191CD G39188ZX G39595FH G41247ZX G44444MB G45209NR G45359RY G45546UR G48414YA G50045TK G50282JC G51640FO G53280MT G55220VL G55521GY G57789QC G59575FI G60723SV G61138BO G61334IA G61962FK G63889NK G64394MX G66129DI G71470CO G72291OX G72735IY G72797UR G74239ZQ G74724QE G75594YZ G77252PU G78059CC G78790NZ G79809MM G80966KZ G81263BG G81349OI G82348BZ G82350PP G82463GQ G83161QT G83460ZZ G84349RE G84452RH G86357DX G90093AU G90448RI G90575OW G90717TP G91413ZX G92050GC G92275SC G93180LE G93284HQ G97183VL G97720QM	Kanzaki disease Schindler disease type 1 angiokeratoma neuroaxonal dystrophy	DOID:0112318 DOID:0112319 DOID:2367 DOID:479	alpha-N-acetylgalactosaminidase activity alpha-galactosidase activity carbohydrate catabolic process cytoplasm extracellular exosome glycolipid catabolic process glycoside catabolic process lysosome membrane oligosaccharide metabolic process protein homodimerization activity	GO:0004557 GO:0005737 GO:0005764 GO:0008456 GO:0009311 GO:0016020 GO:0016052 GO:0016139 GO:0019377 GO:0042803 GO:0070062
Q66H12	Alpha-N-acetylgalactosaminidase	Naga	Rattus norvegicus (Norway rat)	10116	4	0				alpha-N-acetylgalactosaminidase activity alpha-galactosidase activity carbohydrate catabolic process cytoplasm glycolipid catabolic process glycoside catabolic process lysosome membrane oligosaccharide metabolic process protein homodimerization activity	GO:0004557 GO:0005737 GO:0005764 GO:0008456 GO:0009311 GO:0016020 GO:0016052 GO:0016139 GO:0019377 GO:0042803
Q58DH9	Alpha-N-acetylgalactosaminidase	NAGA	Bos taurus (domestic cattle)	9913	5	0				alpha-N-acetylgalactosaminidase activity alpha-galactosidase activity carbohydrate catabolic process cytoplasm glycolipid catabolic process glycoside catabolic process lysosome membrane oligosaccharide metabolic process	GO:0004557 GO:0005737 GO:0005764 GO:0008456 GO:0009311 GO:0016020 GO:0016052 GO:0016139 GO:0019377
Q90744	Alpha-N-acetylgalactosaminidase	NAGA	Gallus gallus (chicken)	9031	3	0				alpha-N-acetylgalactosaminidase activity alpha-galactosidase activity cytoplasm glycoside catabolic process lipid metabolic process lysosome oligosaccharide metabolic process	GO:0004557 GO:0005737 GO:0005764 GO:0006629 GO:0008456 GO:0009311 GO:0016139
Q8RX86	Alpha-galactosidase 2	AGAL2 At5g08370 F8L15.100	Arabidopsis thaliana (thale cress)	3702	3	0				alpha-galactosidase activity apoplast carbohydrate metabolic process cell wall organization leaf morphogenesis plant-type cell wall positive regulation of flower development response to fungus secretory vesicle	GO:0004557 GO:0005975 GO:0009505 GO:0009620 GO:0009911 GO:0009965 GO:0048046 GO:0071555 GO:0099503
Q9FT97	Alpha-galactosidase 1	AGAL1 At5g08380 F8L15.110	Arabidopsis thaliana (thale cress)	3702	2	0				alpha-galactosidase activity apoplast carbohydrate metabolic process cell wall organization plant-type cell wall secretory vesicle	GO:0004557 GO:0005975 GO:0009505 GO:0048046 GO:0071555 GO:0099503
Q8VXZ7	Alpha-galactosidase 3	AGAL3 At3g56310 F18O21.270	Arabidopsis thaliana (thale cress)	3702	5	0				alpha-galactosidase activity apoplast carbohydrate metabolic process cell wall organization plant-type vacuole secretory vesicle vacuole	GO:0000325 GO:0004557 GO:0005773 GO:0005975 GO:0048046 GO:0071555 GO:0099503
A2QL72	Probable alpha-galactosidase A	An06g00170 aglA	Aspergillus niger CBS 513.88	425011	8	0				alpha-galactosidase activity carbohydrate binding carbohydrate metabolic process extracellular region galactosidase activity hydrolase activity, acting on glycosyl bonds	GO:0004557 GO:0005576 GO:0005975 GO:0015925 GO:0016798 GO:0030246
P28351	Alpha-galactosidase A	aglA	Aspergillus niger	5061	7	9	G06110VR G19958IL G39188ZX G55220VL G56960KY G60230HH G65370RS G70101JE G80966KZ			alpha-galactosidase activity carbohydrate binding carbohydrate metabolic process extracellular region	GO:0004557 GO:0005576 GO:0005975 GO:0030246
Q2UT06	Probable alpha-galactosidase A	AO090005000217 aglA	Aspergillus oryzae RIB40	510516	6	0				alpha-galactosidase activity carbohydrate binding carbohydrate metabolic process extracellular region	GO:0004557 GO:0005576 GO:0005975 GO:0030246
B8MWJ5	Probable alpha-galactosidase A	AFLA_074520 aglA	Aspergillus flavus NRRL3357	332952	6	0				alpha-galactosidase activity carbohydrate binding carbohydrate metabolic process extracellular region	GO:0004557 GO:0005576 GO:0005975 GO:0030246
Q4WVZ3	Probable alpha-galactosidase A	AFUA_5G13830 aglA	Aspergillus fumigatus Af293	330879	4	0				alpha-galactosidase activity carbohydrate binding carbohydrate metabolic process extracellular region	GO:0004557 GO:0005576 GO:0005975 GO:0030246
A1CBW8	Probable alpha-galactosidase A	ACLA_016820 aglA	Aspergillus clavatus NRRL 1	344612	4	0				alpha-galactosidase activity carbohydrate binding carbohydrate metabolic process extracellular region	GO:0004557 GO:0005576 GO:0005975 GO:0030246
A1DDD8	Probable alpha-galactosidase A	NFIA_073100 aglA	Aspergillus fischeri NRRL 181	331117	4	0				alpha-galactosidase activity carbohydrate binding carbohydrate metabolic process extracellular region	GO:0004557 GO:0005576 GO:0005975 GO:0030246
Q0CPK2	Probable alpha-galactosidase A	ATEG_04382 aglA	Aspergillus terreus NIH2624	341663	6	0				alpha-galactosidase activity carbohydrate binding carbohydrate metabolic process extracellular region	GO:0004557 GO:0005576 GO:0005975 GO:0030246
Q92457	Alpha-galactosidase 2	agl2	Trichoderma reesei	51453	9	0				alpha-galactosidase activity carbohydrate catabolic process extracellular region	GO:0004557 GO:0005576 GO:0016052

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