Defective ABCG8 causes GBD4 and sitosterolemia
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Defective ABCG5 causes sitosterolemia
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Ciprofloxacin ADME
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- ABCG2
- ABCP
- ALB
- BCRP
- BCRP1
- MXR
- OAT3
- OATP
- OATP1
- OATP1A2
- OCT1
- SLC21A3
- SLC22A1
- SLC22A8
- SLCO1A2
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Heme biosynthesis
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- ABCG2
- ABCP
- ALAD
- ALAS1
- ALAS2
- ALAS3
- ALASE
- ALASH
- ALB
- ASB
- BCRP
- BCRP1
- COX10
- COX15
- CPO
- CPOX
- CPX
- FECH
- HMBS
- MXR
- PBGD
- PPOX
- UPS
- UROD
- UROS
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Iron uptake and transport
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- ABCG2
- ABCP
- ACO1
- BCRP
- BCRP1
- BOCT
- BOIT
- CAND1
- CP
- CUL1
- CYBRD1
- DCT1
- DCYTB
- DMT1
- EMC19
- FBL4
- FBL5
- FBXL5
- FLR1
- FPN
- FPN1
- FRRS3
- FTH
- FTH1
- FTHL6
- FTL
- FTMT
- G21
- GLRX3
- HCP1
- HEPH
- HMOX1
- HMOX2
- HNL
- HO
- HO1
- HO2
- IREB1
- IREB2
- IREG1
- KIAA0698
- KIAA0829
- LCN2
- MXR
- NEDD8
- NGAL
- NRAMP2
- OCP2
- PCFT
- PICOT
- RPS27A
- SKP1
- SKP1A
- SLC11A2
- SLC11A3
- SLC22A17
- SLC40A1
- SLC46A1
- TCEB1L
- TF
- TIP120
- TIP120A
- TXNL2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
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OAS antiviral response
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- ABCE1
- DDX58
- FLN
- FLN1
- FLNA
- OAS1
- OAS2
- OAS3
- OASL
- OIAS
- PDE12
- RIGI
- RLI
- RNASEL
- RNASEL1
- RNASELI
- RNS4
- RNS4I
- TRIP14
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Interferon alpha/beta signaling
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- ABCE1
- ADAR
- ADAR1
- BIRC4BP
- BST2
- CD225
- CIG-42
- CIG-49
- CIG5
- CIS3
- DSRAD
- EGR1
- EIF2AK2
- G10P1
- G10P2
- G1P1
- G1P2
- G1P3
- GBP2
- HCP
- HEM45
- HLA-5.4
- HLA-6.0
- HLA-6.2
- HLA-A
- HLA-B
- HLA-C
- HLA-E
- HLA-F
- HLA-G
- HLA-H
- HLAA
- HLAB
- HLAC
- HLAE
- HLAF
- HLAG
- HLAH
- ICSBP1
- IFB
- IFI17
- IFI27
- IFI35
- IFI4
- IFI54
- IFI56
- IFI6
- IFI60
- IFIT1
- IFIT2
- IFIT3
- IFIT4
- IFIT5
- IFITM1
- IFITM2
- IFITM3
- IFNA1
- IFNA10
- IFNA13
- IFNA14
- IFNA16
- IFNA17
- IFNA2
- IFNA21
- IFNA2A
- IFNA2B
- IFNA2C
- IFNA4
- IFNA5
- IFNA6
- IFNA7
- IFNA8
- IFNAI1
- IFNAR
- IFNAR1
- IFNB
- IFNB1
- IFP35
- IHPK2
- IP6K2
- IRF1
- IRF2
- IRF3
- IRF4
- IRF5
- IRF6
- IRF7
- IRF8
- IRF9
- ISG15
- ISG20
- ISG54
- ISG56
- ISG58
- ISG60
- ISGF3G
- JAK1
- JAK1A
- JAK1B
- KPNA1
- KPNB1
- KROX24
- LMP7
- MOP5
- MUM1
- MX1
- MX2
- N
- NTF97
- OAS1
- OAS2
- OAS3
- OASL
- OIAS
- PKR
- PRKR
- PSMB5i
- PSMB8
- PTP1C
- PTP2C
- PTPN11
- PTPN6
- RCH2
- RI58
- RING10
- RLI
- RNASEL
- RNASEL1
- RNASELI
- RNS4
- RNS4I
- RPS27A
- RSAD2
- SAMHD1
- SHPTP2
- SOCS1
- SOCS3
- SSI1
- SSI3
- STAT1
- STAT2
- TIP3
- TRIP14
- TYK2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- UCRP
- XAF1
- XIAPAF1
- Y2
- ZNF225
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Defective ABCD4 causes MAHCJ
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- ABCD4
- C6orf209
- LMBRD1
- NESI
- PXMP1L
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Uptake of dietary cobalamins into enterocytes
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- ABCD4
- AMN
- C6orf209
- CBLIF
- CTRB
- CTRB1
- CTRB2
- CUBN
- GIF
- IFCR
- IFMH
- LMBRD1
- NESI
- PRSS1
- PRSS3
- PRSS4
- PXMP1L
- TC1
- TCN1
- TRP1
- TRY1
- TRY3
- TRY4
- TRYP1
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RHOC GTPase cycle
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- ABCD3
- ABR
- ACBD5
- AKAP13
- ANLN
- ARH12
- ARH9
- ARHA
- ARHC
- ARHGAP1
- ARHGAP10
- ARHGAP18
- ARHGAP21
- ARHGAP26
- ARHGAP32
- ARHGAP35
- ARHGAP39
- ARHGAP5
- ARHGAP7
- ARHGDIA
- ARHGEF1
- ARHGEF10
- ARHGEF10L
- ARHGEF11
- ARHGEF12
- ARHGEF17
- ARHGEF25
- ARHGEF28
- ARHGEF40
- ARHGEF5
- BCR
- BCR1
- BND7
- BRX
- C1QBP
- CAV
- CAV1
- CAVIN1
- CCDC187
- CDC42GAP
- CIT
- CRIK
- CTNNG
- D22S11
- DAAM1
- DBL
- DEPDC1B
- DIAP1
- DIAP3
- DIAPH1
- DIAPH3
- DLC1
- DLC2
- DP3
- EPB72
- ERBB2IP
- ERBIN
- ERGIC53
- ESA1
- F5F8D
- FHOD2
- FHOD3
- FLOT1
- FLOT2
- FMNL2
- FMNL3
- FRL2
- GC1QBP
- GDIA1
- GEFT
- GRAF
- GRB1
- GRF1
- GRINCHGEF
- GRIT
- GRLF1
- GT650
- HABP1
- HT31
- IQGAP1
- IQGAP3
- JUP
- KIAA0051
- KIAA0204
- KIAA0294
- KIAA0337
- KIAA0362
- KIAA0380
- KIAA0382
- KIAA0619
- KIAA0621
- KIAA0666
- KIAA0712
- KIAA0949
- KIAA1225
- KIAA1415
- KIAA1424
- KIAA1478
- KIAA1626
- KIAA1688
- KIAA1722
- KIAA1723
- KIAA1902
- KIAA1996
- KIAA1998
- KIAA2014
- LAP2
- LARG
- LBC
- LBR
- LMAN1
- LOK
- M17S1
- MACO1
- MCAM
- MCF2
- MCF2L
- MGCRACGAP
- MUC18
- MYO9B
- MYR5
- OPHN1
- OPHN1L
- OST
- P190A
- PAK1
- PIK3R1
- PKN
- PKN1
- PKN2
- PKN3
- PKNBETA
- PMP70
- PREX1
- PRK1
- PRK2
- PRKCL1
- PRKCL2
- PTRF
- PXMP1
- RACGAP1
- RGNEF
- RHO12
- RHOA
- RHOC
- RHOGAP1
- RHOGAP5
- RICS
- ROCK1
- ROCK2
- RTKN
- RTKN1
- SF2P32
- SLK
- SOLO
- STARD12
- STARD13
- STB2
- STK10
- STK2
- STK21
- STOM
- STX5
- STX5A
- SYB3
- TEM4
- TFRC
- TIM
- TJP2
- TMEM57
- TMPO
- VAMP3
- VANGL1
- VAPB
- VAV2
- WBP3
- X104
- XTP8
- ZO2
- p190ARHOGAP
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Defective ABCD1 causes ALD
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Linoleic acid (LA) metabolism
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- ABCD1
- ACSL1
- ALD
- CIG30
- ELG3
- ELOVL1
- ELOVL2
- ELOVL3
- ELOVL5
- FACL1
- FACL2
- FADS1
- FADS2
- FADSD5
- LACS
- LACS1
- LACS2
- SSC1
- SSC2
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alpha-linolenic acid (ALA) metabolism
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- ABCD1
- ACAA
- ACAA1
- ACOT8
- ACSL1
- ACTEIII
- ALD
- CIG30
- EDH17B4
- ELG3
- ELOVL1
- ELOVL2
- ELOVL3
- ELOVL5
- FACL1
- FACL2
- FADS1
- FADS2
- FADSD5
- HSD17B4
- LACS
- LACS1
- LACS2
- PTE1
- PTHIO
- SCP2
- SDR8C1
- SSC1
- SSC2
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Beta-oxidation of very long chain fatty acids
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- ABCD1
- ACAA
- ACAA1
- ACOT4
- ACOT6
- ACOT8
- ACTEIII
- ALD
- C14orf42
- DECR2
- ECHD
- EDH17B4
- EHHADH
- HSD17B4
- PDCR
- PTE1
- PTE2B
- PTEIB
- PTHIO
- SDR17C1
- SDR8C1
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Class I peroxisomal membrane protein import
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- ABCD1
- ABCD2
- ABCD3
- ACBD5
- ALD
- ALD1
- ALDL1
- ALDR
- ALDRP
- ATAD1
- FIS1
- GDAP1
- HK33
- KIAA1996
- PAF1
- PAF3
- PEX11B
- PEX12
- PEX13
- PEX14
- PEX16
- PEX19
- PEX2
- PEX26
- PEX3
- PMP22
- PMP24
- PMP3
- PMP34
- PMP35
- PMP70
- PXF
- PXMP1
- PXMP2
- PXMP3
- PXMP4
- RNF72
- SLC25A17
- TTC11
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Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome
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Ion homeostasis
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- ABCC9
- AHCYL1
- ASPH
- ATP1A1
- ATP1A2
- ATP1A3
- ATP1A4
- ATP1AL2
- ATP1B
- ATP1B1
- ATP1B2
- ATP1B3
- ATP1C
- ATP1G1
- ATP2A1
- ATP2A2
- ATP2A3
- ATP2B
- ATP2B1
- ATP2B2
- ATP2B3
- ATP2B4
- BAH
- C7orf19
- CALM
- CALM1
- CAM
- CAM1
- CAM2
- CAMK
- CAMK-II
- CAMK2
- CAMK2A
- CAMK2B
- CAMK2D
- CAMK2G
- CAMKA
- CAMKB
- CAMKD
- CAMKG
- CBCIP2
- CLIC2
- CNC
- CRACM1
- DCAL
- DM1PK
- DMPK
- FKBP12.6
- FKBP1B
- FKBP1L
- FKBP9
- FXYD1
- FXYD2
- FXYD3
- FXYD4
- FXYD6
- FXYD7
- GOK
- HBRR
- INSP3R1
- IRBIT
- ITPR1
- ITPR2
- ITPR3
- KCNJ11
- KIAA0778
- KIAA0968
- KIAA1087
- MAT8
- MDPK
- MXRA1
- NCX1
- NCX2
- NCX3
- NOS1
- ORAI1
- ORAI2
- OTK4
- PKACA
- PLB
- PLM
- PLML
- PLN
- PMCA1
- PMCA2
- PRKACA
- RYDR
- RYR1
- RYR2
- RYR3
- SLC8A1
- SLC8A2
- SLC8A3
- SLN
- SRI
- STIM1
- SUR2
- TMEM142A
- TMEM142B
- TNNC1
- TNNI3
- TRDN
- TRP1
- TRPC1
- XPVKONA
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Defective ABCC8 can cause hypo- and hyper-glycemias
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- ABCC8
- HRINS
- KCNJ11
- SUR
- SUR1
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Regulation of insulin secretion
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- ABCC8
- AHCYL1
- CACH2
- CACH3
- CACH4
- CACH6
- CACN2
- CACN3
- CACN4
- CACNA1A
- CACNA1C
- CACNA1D
- CACNA1E
- CACNA2D2
- CACNB2
- CACNB3
- CACNL1A1
- CACNL1A2
- CACNL1A4
- CACNL1A6
- CACNLB2
- CACNLB3
- CCHL1A1
- CCHL1A2
- CGEF1
- CGEF2
- DCAL
- EPAC
- EPAC1
- EPAC2
- GLUT1
- GLUT2
- GNAI1
- GNAI2
- GNAI2B
- HRINS
- INS
- INSP3R1
- IRBIT
- ITPR1
- ITPR2
- ITPR3
- KCNJ11
- KIAA0558
- MYSB
- PKACA
- PRKACA
- PRKACB
- PRKACG
- RAPGEF3
- RAPGEF4
- SLC2A1
- SLC2A2
- SNAP
- SNAP25
- STX1
- STX1A
- STXBP1
- SUR
- SUR1
- SYB2
- SYT5
- UNC18A
- VAMP2
- XPVKONA
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ATP sensitive Potassium channels
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- ABCC8
- ABCC9
- HRINS
- KCNJ11
- KCNJ8
- SUR
- SUR1
- SUR2
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Defective CFTR causes cystic fibrosis
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- ABCC7
- C10orf69
- C22orf14
- C2orf30
- C7orf76
- C8orf2
- CFTR
- DER1
- DER2
- DER3
- DERL1
- DERL2
- DERL3
- DSS1
- ERLEC1
- ERLIN1
- ERLIN2
- FLANA
- G16
- HC2
- HC3
- HC8
- HC9
- HEL-220
- HEL-S-70
- HSPC
- IFI5111
- KE04
- KEO4
- KIAA0072
- KIAA0077
- KIAA0107
- LLN2
- LMP10
- LMP2
- LMP7
- LMPX
- LMPY
- MB1
- MCB1
- MECL1
- MIP224
- MOV34L
- MSS1
- NG2
- NU
- OS9
- PFAAP4
- POH1
- PROS26
- PROS27
- PROS30
- PSC2
- PSC3
- PSC5
- PSC8
- PSC9
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMA7L
- PSMA8
- PSMB1
- PSMB10
- PSMB11
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB5i
- PSMB6
- PSMB6i
- PSMB7
- PSMB8
- PSMB9
- PSMC1
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD10
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD4
- PSMD5
- PSMD6
- PSMD7
- PSMD8
- PSMD9
- PSME1
- PSME2
- PSME3
- PSME4
- PSMF1
- RING10
- RING12
- RMA1
- RNF185
- RNF5
- RPS27A
- SEL1L
- SEM1
- SHFDG1
- SHFM1
- SPFH1
- SPFH2
- SUG1
- SUG2
- TBP1
- TBP7
- TRAP2
- TSA305
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- VCP
- X
- XTP3TPB
- Y
- Y2
- Z
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Aggrephagy
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- ABCC7
- ARL13B
- ARL2L1
- BLU
- CEN1
- CETN
- CETN1
- CFTR
- CROC1
- DHC1
- DLC1
- DLC2
- DNCH1
- DNCI1
- DNCI2
- DNCIC1
- DNCIC2
- DNCL
- DNCL1
- DNCLC1
- DNCLI1
- DNCLI2
- DNECL
- DYHC
- DYNC1H1
- DYNC1I1
- DYNC1I2
- DYNC1LI1
- DYNC1LI2
- DYNLL1
- DYNLL2
- HDAC6
- HDLC1
- HEL-220
- HEL-S-70
- HSF1
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- HSTF1
- IFT88
- KIAA0325
- KIAA0402
- KIAA0901
- LIC2
- PARK2
- PARK7
- PCNT
- PCNT2
- PRKN
- RPS27A
- TG737
- TTC10
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- UBE2N
- UBE2V
- UBE2V1
- UEV1
- VCP
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RHO GTPases regulate CFTR trafficking
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- ABCC7
- ARHQ
- CAL
- CFTR
- FIG
- GOPC
- RASL7A
- RHOQ
- TC10
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RHOQ GTPase cycle
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- ABCC7
- ARHDH9
- ARHGAP1
- ARHGAP10
- ARHGAP17
- ARHGAP21
- ARHGAP26
- ARHGAP32
- ARHGAP33
- ARHGAP34
- ARHGAP35
- ARHGAP5
- ARHGAP7
- ARHGEF7
- ARHGEF9
- ARHQ
- ARL13B
- ARL2L1
- ASCT2
- BND7
- BORG1
- BORG2
- BORG4
- BORG5
- BT
- C11orf59
- C6orf114
- CAL
- CAV
- CAV1
- CDC42
- CDC42BPA
- CDC42BPB
- CDC42EP1
- CDC42EP2
- CDC42EP3
- CDC42EP4
- CDC42GAP
- CEP1
- CEP2
- CEP3
- CEP4
- CFTR
- CIP4
- COOL1
- CPNE8
- CRIB1
- CTNNG
- DEPDC1B
- DIAP3
- DIAPH3
- DLC1
- DP3
- EPB72
- FBP17
- FIG
- FNBP1
- FNBP2
- GFOD1
- GIT1
- GIT2
- GJA1
- GJAL
- GOPC
- GRAF
- GRF1
- GRIT
- GRLF1
- IQGAP1
- IQGAP3
- ITSN
- ITSN1
- JUP
- KIAA0051
- KIAA0142
- KIAA0147
- KIAA0148
- KIAA0424
- KIAA0451
- KIAA0456
- KIAA0554
- KIAA0599
- KIAA0621
- KIAA0712
- KIAA1124
- KIAA1142
- KIAA1415
- KIAA1424
- KIAA1556
- KIAA1639
- KIAA1722
- KIAA1723
- LAMTOR1
- LAP4
- M7V1
- MPP7
- MSE55
- NBC2
- NBC2B
- NBC3
- NBCn1
- OBSCN
- OPHN1
- OPHN1L
- P190A
- P85SPR
- PAK1
- PAK2
- PAK3BP
- PAK4
- PDRO
- PIXB
- PLEKHG3
- PREX1
- RAB7
- RAB7A
- RASL7A
- RDR
- RDRC
- RHOGAP1
- RHOGAP5
- RHOQ
- RICH1
- RICS
- SBC2
- SCRB1
- SCRIB
- SH3D1A
- SLC1A5
- SLC4A6
- SLC4A7
- SNAP23
- SNX26
- SRGAP2
- SRGAP2A
- STARD12
- STB2
- STEAP3
- STOM
- STOT
- STP
- SYB3
- SYDE1
- TC10
- TCGAP
- TFRC
- TRIP10
- TSAP6
- VAMP3
- VANGL1
- VARTUL
- WASL
- WWP2
- XTP8
- p190ARHOGAP
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Chaperone Mediated Autophagy
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- ABCC7
- ADFP
- ARL13B
- ARL2L1
- CEN1
- CETN
- CETN1
- CFTR
- EEF1A
- EEF1A1
- EF1A
- GFAP
- HBB
- HDAC6
- HSC70
- HSP73
- HSP90A
- HSP90AA1
- HSP90AB1
- HSP90B
- HSPA10
- HSPA8
- HSPC1
- HSPC2
- HSPC3
- HSPCA
- HSPCB
- IFT88
- KIAA0402
- KIAA0901
- LAMP2
- LENG7
- M6PRBP1
- PARK7
- PCNT
- PCNT2
- PLIN2
- PLIN3
- RIB1
- RNASE1
- RNS1
- RPS27A
- TG737
- TIP47
- TTC10
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
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