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MIRAGE
Alzheimer's disease

Summary
Synonym
  • Alzheimer disease
  • Alzheimers dementia
Definition
A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
Super Class
tauopathy
Disease Ontology
DOID:10652
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 1 - 10 of 104 in total
Gene ID Gene Symbol Description Source
2 A2M alpha-2-macroglobulin
18 ABAT 4-aminobutyrate aminotransferase
19 ABCA1 ATP binding cassette subfamily A member 1
43 ACHE acetylcholinesterase (Yt blood group)
142 PARP1 poly(ADP-ribose) polymerase 1
148 ADRA1A adrenoceptor alpha 1A
155 ADRB3 adrenoceptor beta 3
177 AGER advanced glycosylation end-product specific receptor
185 AGTR1 angiotensin II receptor type 1
217 ALDH2 aldehyde dehydrogenase 2 family member
Displaying all 3 entries
Gene ID Gene Symbol Description Source
11820 App amyloid beta precursor protein
16971 Lrp1 low density lipoprotein receptor-related protein 1
17380 Mme membrane metallo endopeptidase
Displaying entries 1 - 10 of 13 in total
Gene ID Gene Symbol Description Source
24225 Bdnf brain-derived neurotrophic factor
24310 Ace angiotensin I converting enzyme
24383 Gapdh glyceraldehyde-3-phosphate dehydrogenase
25595 Map2 microtubule-associated protein 2
25608 Lep leptin
25718 Igf1r insulin-like growth factor 1 receptor
29527 Ptgs2 prostaglandin-endoperoxide synthase 2
29595 Htr2a 5-hydroxytryptamine receptor 2A
54226 App amyloid beta precursor protein
63868 Hspd1 heat shock protein family D (Hsp60) member 1
Displaying all 6 entries
Gene ID Gene Symbol Description Source
31002 Appl beta amyloid protein precursor-like
32342 amrt amaretto
37443 bisc biscotti
40260 Psn Presenilin
42964 Nct Nicastrin
43869 amx almondex
Displaying all 2 entries
Gene ID Gene Symbol Description Source
176282 lin-12 lin-12/Notch intracellular domain
180783 apl-1 Amyloid-beta-like protein
Displaying 1 entry
Gene ID Gene Symbol Description Source
855897 HRR25 serine/threonine protein kinase HRR25
Related Glycoprotein
Displaying 1 entry
UniProt ID Protein Name Source
P29295 Casein kinase I homolog HRR25
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025