GlyCosmos Portal

Mus musculus (house mouse)

Summary

Taxonomy ID: 10090
PubChem Taxonomy: 10090

Genes (662) Glycans (1270) Glycoproteins (13000) Lectins (276) Pathways (1335)

Displaying entries **976 - 1000** of **1335** in total

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Pathway Name	Protein Name ▲	UniProt ID	Gene Symbol
activated TAK1 mediates p38 MAPK activation	Dual specificity mitogen-activated protein kinase kinase 3 Dual specificity mitogen-activated protein kinase kinase 6 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase-like 2 MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Nucleotide-binding oligomerization domain-containing protein 1 Nucleotide-binding oligomerization domain-containing protein 2 Receptor-interacting serine/threonine-protein kinase 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	O09110 O88522 P47811 P49138 P58801 P61089 P70196 P70236 Q3UMW7 Q571K4 Q62073 Q62406 Q8BHB0 Q8CF89 Q8CFA1 Q8K3Z0 Q99K90 Q9CZY3 Q9WUI1	Blu Card15 Crk1 Croc1 Csbp1 Csbp2 Ikbkg Il1rak Irak1 Irak2 Kiaa0733 Kiaa4135 Map2k3 Map2k6 Map3k7 Map3k7ip1 Map3k7ip2 Map3k7ip3 Mapk11 Mapk14 Mapkapk2 Mapkapk3 Mkk3 Nemo Nod1 Nod2 Prkm11 Prkmk3 Prkmk6 Rip2 Ripk2 Rps6kc1 Sapkk3 Tab1 Tab2 Tab3 Tak1 Traf6 Ube2n Ube2v1
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	Dual specificity mitogen-activated protein kinase kinase 4 Dual specificity mitogen-activated protein kinase kinase 7 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase-like 2 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Nucleotide-binding oligomerization domain-containing protein 1 Nucleotide-binding oligomerization domain-containing protein 2 Receptor-interacting serine/threonine-protein kinase 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	O88522 P47809 P58801 P61089 P70196 Q571K4 Q61831 Q62073 Q62406 Q8BHB0 Q8CE90 Q8CF89 Q8CFA1 Q8K3Z0 Q91Y86 Q99K90 Q9CZY3 Q9WTU6	Blu Card15 Croc1 Ikbkg Il1rak Irak1 Irak2 Jnk1 Jnk2 Jnk3 Jnkk1 Kiaa0733 Kiaa4135 Map2k4 Map2k7 Map3k7 Map3k7ip1 Map3k7ip2 Map3k7ip3 Mapk10 Mapk8 Mapk9 Mek4 Mkk4 Mkk7 Nemo Nod1 Nod2 Prkm10 Prkm8 Prkm9 Prkmk4 Rip2 Ripk2 Sek1 Serk1 Serk2 Skk1 Tab1 Tab2 Tab3 Tak1 Traf6 Ube2n Ube2v1
ERKs are inactivated	Dual specificity protein phosphatase 3 Dual specificity protein phosphatase 4 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 7 Serine/threonine-protein kinase VRK3 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	P62715 P63085 P63330 Q63844 Q76MZ3 Q7TNL5 Q7TNP2 Q8BFV3 Q8K3G5 Q91Z46 Q9D7X3 Q9DBB1 Q9WVS8	Bmk1 Dusp3 Dusp4 Dusp6 Dusp7 Erk1 Erk2 Erk5 Mapk Mapk1 Mapk3 Mapk7 Mkp3 Ppp2ca Ppp2cb Ppp2r1a Ppp2r1b Ppp2r5d Prkm1 Prkm3 Vrk3
Regulation of Apoptosis	Dynamin-like GTPase OPA1, mitochondrial Metalloendopeptidase OMA1, mitochondrial	P58281 Q9D8H7	Oma1 Opa1
Regulation of expression of SLITs and ROBOs	Dystroglycan 1 Polyubiquitin-B Polyubiquitin-C Roundabout homolog 1 Slit homolog 2 protein Ubiquitin carboxyl-terminal hydrolase 33 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O89026 P0CG49 P0CG50 P62983 P62984 Q62165 Q8R5K2 Q9R1B9	Dag1 Dutt1 Robo1 Rps27a Slit2 Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2 Usp33 Vdu1
SUMOylation of transcription factors	E3 SUMO-protein ligase PIAS1 E3 SUMO-protein ligase PIAS3 E3 SUMO-protein ligase PIAS4 Forkhead box protein L2 Hypermethylated in cancer 1 protein Metastasis-associated protein MTA1 SUMO-conjugating enzyme UBC9 Small ubiquitin-related modifier 1 Small ubiquitin-related modifier 2 Small ubiquitin-related modifier 3 TP53-binding protein 1 Transcription factor AP-2 gamma Transcription factor Sp3	O54714 O70494 O88470 O88907 P61957 P63166 P63280 P70399 Q61312 Q8K4B0 Q9JM05 Q9R1Y5 Q9Z172	Ddxbp1 Foxl2 Hic1 Mta1 Pfrk Pias1 Pias3 Pias4 Piasg Smt3a Smt3b Smt3c Smt3h1 Smt3h2 Smt3h3 Sp3 Sumo1 Sumo2 Sumo3 Tcfap2c Tfap2c Tp53bp1 Trp53bp1 Ubc9 Ubce2i Ubce9 Ube2i Ubl1
Regulation of IFNG signaling	E3 SUMO-protein ligase PIAS1 Ifngr2 protein Interferon gamma receptor 1 Interferon gamma Signal transducer and activator of transcription 1 Small ubiquitin-related modifier 1 Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 2	O35716 O35718 O88907 P01580 P15261 P42225 P52332 P63166 Q06180 Q62120 Q63953	Cis3 Cish1 Cish3 Ddxbp1 Ifng Ifngr Ifngr1 Ifngr2 Jak1 Jak2 Pias1 Ptpn2 Ptpt Smt3c Smt3h3 Socs1 Socs3 Ssi1 Stat1 Sumo1 Ubl1 ifngr2
SUMOylation of immune response proteins	E3 SUMO-protein ligase PIAS3 E3 SUMO-protein ligase PIAS4 E3 ubiquitin-protein ligase Topors Inhibitor of nuclear factor kappa-B kinase subunit epsilon NF-kappa-B essential modulator NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p100 subunit SUMO-conjugating enzyme UBC9 Small ubiquitin-related modifier 1 Small ubiquitin-related modifier 3 Transcription factor p65	O54714 O88522 P63166 P63280 Q04207 Q80Z37 Q9JM05 Q9R0T8 Q9WTK5 Q9Z172 Q9Z1E3	Ikba Ikbke Ikbkg Ikke Ikki Nemo Nfkb2 Nfkb3 Nfkbia Pias3 Pias4 Piasg Rela Smt3a Smt3c Smt3h1 Smt3h3 Sumo1 Sumo3 Topors Ubc9 Ubce2i Ubce9 Ube2i Ubl1
Negative regulation of MET activity	E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15 Hepatocyte growth factor receptor Hepatocyte growth factor-regulated tyrosine kinase substrate Hepatocyte growth factor Leucine-rich repeats and immunoglobulin-like domains protein 1 Polyubiquitin-B Polyubiquitin-C Receptor-type tyrosine-protein phosphatase eta SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 2 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O88811 P0CG49 P0CG50 P16056 P22682 P35821 P42567 P62983 P62984 P70193 P70297 Q06180 Q08048 Q62419 Q62420 Q62421 Q64455 Q80U87 Q8R550 Q99LI8	Byp Cbl Een1 Eps15 Hbp Hgf Hgs Hrs Kiaa0055 Lrig1 Met Ptpn1 Ptpn2 Ptprj Ptpt Rps27a Ruk Scc1 Seta Sh3d2a Sh3d2b Sh3d2c Sh3d2c2 Sh3gl1 Sh3gl2 Sh3gl3 Sh3kbp1 Stam Stam1 Stam2 Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2 Ubpy Usp8
Negative regulation of FGFR2 signaling	E3 ubiquitin-protein ligase CBL Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 5 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 8 Fibroblast growth factor 9 Fibroblast growth factor receptor 2 Fibroblast growth factor receptor substrate 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Polyubiquitin-B Polyubiquitin-C Tyrosine-protein phosphatase non-receptor type 11 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O35565 O89101 P05524 P0CG49 P0CG50 P11403 P15655 P15656 P21658 P21803 P22682 P35235 P36363 P37237 P54130 P61148 P62983 P62984 P63075 P63085 Q63844 Q8C180 Q9EPC2 Q9ESL8 Q9ESL9 Q9ESS2	Aigf Bek Cbl Ect1 Erk1 Erk2 Fgf-1 Fgf-2 Fgf-3 Fgf-4 Fgf-5 Fgf-6 Fgf-7 Fgf-9 Fgf1 Fgf10 Fgf16 Fgf17 Fgf18 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf6 Fgf7 Fgf8 Fgf9 Fgfa Fgfr2 Frs2 Frs2a Hstf2 Int-2 Kfgf Kgf Mapk Mapk1 Mapk3 Prkm1 Prkm3 Ptpn11 Rps27a Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2
Negative regulation of FGFR1 signaling	E3 ubiquitin-protein ligase CBL Fibroblast growth factor 10 Fibroblast growth factor 17 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 5 Fibroblast growth factor 6 Fibroblast growth factor 8 Fibroblast growth factor 9 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor substrate 2 Klotho Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Polyubiquitin-B Polyubiquitin-C Tyrosine-protein phosphatase non-receptor type 11 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O35082 O35565 P05524 P0CG49 P0CG50 P11403 P15655 P15656 P16092 P21658 P22682 P35235 P37237 P54130 P61148 P62983 P62984 P63075 P63085 Q63844 Q8C180 Q9EPC2 Q9ESL9 Q9ESS2	Aigf Cbl Erk1 Erk2 Fgf-1 Fgf-2 Fgf-3 Fgf-4 Fgf-5 Fgf-6 Fgf-9 Fgf1 Fgf10 Fgf17 Fgf2 Fgf20 Fgf22 Fgf23 Fgf3 Fgf4 Fgf5 Fgf6 Fgf8 Fgf9 Fgfa Fgfr1 Flg Frs2 Frs2a Hstf2 Int-2 Kfgf Kl Mapk Mapk1 Mapk3 Prkm1 Prkm3 Ptpn11 Rps27a Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2
Negative regulation of FGFR3 signaling	E3 ubiquitin-protein ligase CBL Fibroblast growth factor 16 Fibroblast growth factor 17 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 5 Fibroblast growth factor 8 Fibroblast growth factor 9 Fibroblast growth factor receptor 3 Fibroblast growth factor receptor substrate 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Polyubiquitin-B Polyubiquitin-C Tyrosine-protein phosphatase non-receptor type 11 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O89101 P0CG49 P0CG50 P11403 P15655 P15656 P22682 P35235 P37237 P54130 P61148 P62983 P62984 P63075 P63085 Q61851 Q63844 Q8C180 Q9EPC2 Q9ESL8 Q9ESL9	Aigf Cbl Erk1 Erk2 Fgf-1 Fgf-2 Fgf-4 Fgf-5 Fgf-9 Fgf1 Fgf16 Fgf17 Fgf18 Fgf2 Fgf20 Fgf23 Fgf4 Fgf5 Fgf8 Fgf9 Fgfa Fgfr3 Frs2 Frs2a Kfgf Mapk Mapk1 Mapk3 Mfr3 Prkm1 Prkm3 Ptpn11 Rps27a Sam3 Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2
Negative regulation of FLT3	E3 ubiquitin-protein ligase CBL Fms-related tyrosine kinase 3 ligand Polyubiquitin-B Polyubiquitin-C Receptor-type tyrosine-protein kinase FLT3 Receptor-type tyrosine-protein phosphatase eta SH2B adapter protein 3 Src-like-adapter 2 Src-like-adapter Suppressor of cytokine signaling 2 Suppressor of cytokine signaling 6 Tyrosine-protein kinase ABL2 Tyrosine-protein kinase CSK Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O09039 O35717 P0CG49 P0CG50 P22682 P41241 P49772 P62983 P62984 Q00342 Q4JIM5 Q60898 Q64455 Q8R4L0 Q9JLY0	Abl2 Arg Byp Cbl Cis2 Cis4 Cish2 Cish4 Csk Flk-2 Flt-3 Flt3 Flt3l Flt3lg Lnk Ptprj Rps27a Scc1 Sh2b3 Sla Sla2 Slap Slap1 Socs2 Socs4 Socs6 Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2
TGF-beta receptor signaling activates SMADs	E3 ubiquitin-protein ligase CBL Furin Integrin alpha-8 Integrin alpha-V Integrin beta-1 Integrin beta-3 Integrin beta-5 Integrin beta-6 Integrin beta-8 Latent-transforming growth factor beta-binding protein 1 Latent-transforming growth factor beta-binding protein 2 Latent-transforming growth factor beta-binding protein 3 Latent-transforming growth factor beta-binding protein 4 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 NEDD8-conjugating enzyme Ubc12 NEDD8 Peptidyl-prolyl cis-trans isomerase FKBP1A TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta receptor type 3 Transforming growth factor beta-1 proprotein Transforming growth factor beta-2 proprotein Transforming growth factor beta-3 proprotein Zinc finger FYVE domain-containing protein	A2A8R0 A2ARA8 O08999 O54890 O70309 O88393 P04202 P09055 P17125 P22682 P23188 P26883 P27090 P29595 P43406 P61082 P97471 Q0VBD0 Q61810 Q62312 Q62432 Q64729 Q8BUN5 Q8CG19 Q8K4G1 Q9Z0T9	Cbl Dpc4 Fkbp1 Fkbp1a Fur Furin Itga8 Itgav Itgb1 Itgb3 Itgb5 Itgb6 Itgb8 Ltbp1 Ltbp2 Ltbp3 Ltbp4 Madh2 Madh3 Madh4 Madr2 Nedd-8 Nedd8 Pcsk3 Smad2 Smad3 Smad4 Tgfb1 Tgfb2 Tgfb3 Tgfbr1 Tgfbr2 Tgfbr3 Ubc-rs2 Ubc12 Ube2m Zfyve9
Interleukin-6 signaling	E3 ubiquitin-protein ligase CBL Interleukin-6 receptor subunit alpha Interleukin-6 receptor subunit beta Interleukin-6 Non-receptor tyrosine-protein kinase TYK2 Signal transducer and activator of transcription 1 Signal transducer and activator of transcription 3 Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 11	O35718 P08505 P22272 P22682 P35235 P42225 P42227 P52332 Q00560 Q62120 Q9R117	Aprf Cbl Cis3 Cish3 Il-6 Il6 Il6r Il6ra Il6st Jak1 Jak2 Ptpn11 Socs3 Stat1 Stat3 Tyk2
Regulation of KIT signaling	E3 ubiquitin-protein ligase CBL Kit ligand Mast/stem cell growth factor receptor Kit Protein kinase C alpha type Proto-oncogene tyrosine-protein kinase LCK Proto-oncogene tyrosine-protein kinase Src SH2B adapter protein 2 SH2B adapter protein 3 Son of sevenless homolog 1 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes Tyrosine-protein phosphatase non-receptor type 6	O09039 P05480 P05532 P06240 P20444 P20826 P22682 P25911 P29351 P39688 Q04736 Q62245 Q9JID9	Aps Cbl Fyn Hcp Hcph Kit Kitl Kitlg Lck Lnk Lsk-t Lyn Mgf Pkca Prkca Ptp1C Ptpn6 Sh2b2 Sh2b3 Sl Slf Sos1 Src Yes Yes1
Spry regulation of FGF signaling	E3 ubiquitin-protein ligase CBL MAP kinase-interacting serine/threonine-protein kinase 1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Polyubiquitin-B Polyubiquitin-C Protein sprouty homolog 2 Proto-oncogene tyrosine-protein kinase Src Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Tyrosine-protein phosphatase non-receptor type 11 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O08605 P05480 P0CG49 P0CG50 P22682 P28028 P35235 P62715 P62983 P62984 P63085 P63330 Q63844 Q76MZ3 Q9QXV8	B-raf Braf Cbl Erk1 Erk2 Mapk Mapk1 Mapk3 Mknk1 Mnk1 Ppp2ca Ppp2cb Ppp2r1a Prkm1 Prkm3 Ptpn11 Rps27a Spry2 Src Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2
Activated NOTCH1 Transmits Signal to the Nucleus	E3 ubiquitin-protein ligase DTX1 E3 ubiquitin-protein ligase DTX4 E3 ubiquitin-protein ligase Itchy Neurogenic locus notch homolog protein 1 Polyubiquitin-B Polyubiquitin-C Probable E3 ubiquitin-protein ligase DTX2 Protein jagged-2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG49 P0CG50 P62983 P62984 Q01705 Q61010 Q6PDK8 Q8C863 Q8R3P2 Q9QYE5	Dtx1 Dtx2 Dtx4 Itch Jag2 Motch Notch1 Rps27a Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2
Regulation of innate immune responses to cytosolic DNA	E3 ubiquitin-protein ligase DTX4 E3 ubiquitin-protein ligase TRIM21 E3 ubiquitin-protein ligase TRIM32 E3 ubiquitin-protein ligase TRIM56 Interferon regulatory factor 3 NACHT, LRR and PYD domains-containing protein 4C Polyubiquitin-B Polyubiquitin-C Probable ATP-dependent RNA helicase DDX41 Serine/threonine-protein kinase TBK1 Stimulator of interferon genes protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG49 P0CG50 P62983 P62984 P70671 Q3TBT3 Q3TKR3 Q62191 Q6PDK8 Q80VI1 Q8CH72 Q91VN6 Q9WUN2	Ddx41 Dtx4 Eris Irf3 Mita Mpys Nalp4c Nlrp4c Ro52 Rps27a Ssa1 Sting Sting1 Tbk1 Tmem173 Trim21 Trim32 Trim56 Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2
Downregulation of ERBB4 signaling	E3 ubiquitin-protein ligase Itchy E3 ubiquitin-protein ligase NEDD4 NEDD4-like E3 ubiquitin-protein ligase WWP1 Polyubiquitin-B Polyubiquitin-C Proto-oncogene tyrosine-protein kinase Src Receptor tyrosine-protein kinase erbB-4 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P05480 P0CG49 P0CG50 P46935 P62983 P62984 Q61527 Q8BZZ3 Q8C863	Erbb4 Itch Kiaa0093 Mer4 Nedd-4 Nedd4 Nedd4-1 Nedd4a Rpf1 Rps27a Src Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2 Wwp1
Regulation of PTEN localization	E3 ubiquitin-protein ligase NEDD4 E3 ubiquitin-protein ligase XIAP Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Polyubiquitin-B Polyubiquitin-C Protein PML Ubiquitin carboxyl-terminal hydrolase 7 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O08586 P0CG49 P0CG50 P46935 P62983 P62984 Q60953 Q60989 Q6A4J8	Aipa Api3 Birc4 Hausp Kiaa0093 Miha Mmac1 Nedd-4 Nedd4 Nedd4-1 Nedd4a Pml Pten Rpf1 Rps27a Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2 Usp7 Xiap
Downregulation of SMAD2/3:SMAD4 transcriptional activity	E3 ubiquitin-protein ligase NEDD4-like E3 ubiquitin-protein ligase SMURF2 E3 ubiquitin-protein ligase TRIM33 Histone deacetylase 1 Homeobox protein TGIF1 Homeobox protein TGIF2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Poly [ADP-ribose] polymerase 1 Polyubiquitin-B Polyubiquitin-C Protein ATP1B4 Protein phosphatase 1A SNW domain-containing protein 1 Ski oncogene Ski-like protein Ubiquitin carboxyl-terminal hydrolase 9X Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A2A5Z6 O09106 P0CG49 P0CG50 P11103 P49443 P61079 P61080 P62983 P62984 P63085 P70284 P70398 P97471 Q60665 Q60698 Q60974 Q62432 Q63844 Q8BUN5 Q8C0Y1 Q8CFI0 Q99ME6 Q99PP7 Q9CSN1 Q9WU42	Adprp Adprt Adprt1 Atp1b4 Dpc4 Erk1 Erk2 Fafl Fam Hdac1 Kiaa0439 Kiaa1113 Madh2 Madh3 Madh4 Madr2 Mapk Mapk1 Mapk3 Ncor1 Ncor2 Nedd4b Nedd4l Parp1 Ppm1a Pppm1a Prkm1 Prkm3 Rps27a Rxrip13 Ski Skiip Skil Skir Smad2 Smad3 Smad4 Smrt Smurf2 Sno Snw1 Tgif Tgif1 Tgif2 Trim33 Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2 Ube2d1 Ube2d3 Usp9x
Downregulation of ERBB2:ERBB3 signaling	E3 ubiquitin-protein ligase NRDP1 Polyubiquitin-B Polyubiquitin-C Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor tyrosine-protein kinase erbB-2 Receptor tyrosine-protein kinase erbB-3 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A140LHZ9 P0CG49 P0CG50 P31750 P56974 P62983 P62984 P70424 Q60823 Q61526 Q80U87 Q8BH75 Q9WUA6	Akt Akt1 Akt2 Akt3 Erbb2 Erbb3 Flrf Kiaa0055 Kiaa3023 Neu Nrdp1 Nrg1 Nrg2 Rac Rnf41 Rps27a Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2 Ubpy Usp8
Regulation of FZD by ubiquitination	E3 ubiquitin-protein ligase RNF43 E3 ubiquitin-protein ligase ZNRF3 Frizzled-4 Frizzled-5 Frizzled-6 Frizzled-8 Insulin-like growth factor-binding protein complex acid labile subunit Leucine-rich repeat-containing G-protein coupled receptor 5 Low-density lipoprotein receptor-related protein 5 Low-density lipoprotein receptor-related protein 6 Polyubiquitin-B Polyubiquitin-C Protein Wnt-3a R-spondin-1 R-spondin-2 R-spondin-3 R-spondin-4 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O88572 P0CG49 P0CG50 P27467 P62983 P62984 P70389 Q2TJ95 Q5NCP0 Q5SSZ7 Q61088 Q61089 Q61091 Q80U87 Q8BFU0 Q8BJ73 Q91VN0 Q9EQD0 Q9Z132 Q9Z1P4	Albs Als Fex Fzd4 Fzd5 Fzd6 Fzd8 Gpr49 Igfals Kiaa0055 Lgr5 Lr3 Lrp5 Lrp6 Lrp7 Rnf43 Rps27a Rspo1 Rspo2 Rspo3 Rspo4 Uba52 Uba80 Ubb Ubc Ubcep1 Ubcep2 Ubpy Usp8 Wnt-3a Wnt3a Znrf3
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	E3 ubiquitin-protein ligase pellino homolog 1 E3 ubiquitin-protein ligase pellino homolog 2 E3 ubiquitin-protein ligase pellino homolog 3 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Interleukin-1 receptor-associated kinase 1 NF-kappa-B essential modulator TNF receptor-associated factor 6 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	O88351 O88522 P61089 P70196 Q60680 Q62406 Q8BST6 Q8BXR6 Q8C669 Q9CZY3	Blu Chuk Croc1 Ikbkb Ikbkg Ikka Ikkb Il1rak Irak1 Nemo Peli1 Peli2 Peli3 Traf6 Ube2n Ube2v1

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