MyD88 dependent cascade initiated on endosome
|
|
|
- IRAK
- IRAK1
- IRAK2
- IRAK4
- MYD88
- RNF85
- TLR7
- TLR9
- TRAF6
|
|
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
|
|
|
- ECSIT
- IRAK
- IRAK1
- IRAK2
- IRAK4
- MAP3K1
- MAPKKK1
- MEKK
- MEKK1
- MYD88
- RNF85
- TLR7
- TLR9
- TRAF6
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|
MyD88 cascade initiated on plasma membrane
|
|
|
- ECSIT
- IRAK
- IRAK1
- IRAK2
- IRAK4
- MAP3K1
- MAPKKK1
- MEKK
- MEKK1
- MYD88
- RNF85
- TIL3
- TLR10
- TLR5
- TRAF6
- flaF
- fliC
- hag
|
|
SARS-CoV-1 activates/modulates innate immune responses
|
|
|
- 1a
- 3a
- 3b
- 6
- 7a
- 8b
- 9b
- AML1
- ASC
- BST2
- C1orf7
- CAP-1
- CARD5
- CASP1
- CBFA2
- CIAS1
- COLEC7
- CRAF1
- CYP20
- CYPA
- CYPB
- CYPH
- DAK
- DDX58
- DSCR1L2
- E
- EFP
- ERIS
- FKBP1
- FKBP12
- FKBP1A
- IFIH1
- IKBA
- IKBKE
- IKKE
- IKKI
- IL1BC
- IL1BCE
- IPS1
- IRAK2
- IRF3
- ITCH
- KIAA0151
- KIAA0220
- KIAA0719
- KIAA1271
- KPNA2
- KPNB1
- M
- MAD3
- MAVS
- MDA5
- MITA
- N
- NAK
- NALP3
- NFKB1
- NFKB3
- NFKBI
- NFKBIA
- NLRP3
- NMI
- NPIPB3
- NPIPL3
- NTF97
- PCBP2
- PPIA
- PPIB
- PPIG
- PPIH
- PSPD
- PYCARD
- PYPAF1
- RCAN3
- RCH1
- RELA
- RH116
- RIGI
- RIP3
- RIPK3
- RNF147
- RNF85
- RPS27A
- RUNX1
- S
- SFTP4
- SFTPD
- SIKE
- SIKE1
- SRP1
- STING
- STING1
- TBK1
- TKFC
- TLR7
- TMEM173
- TMS1
- TOM70
- TOMM70
- TOMM70A
- TRAF3
- TRAF6
- TRAFAMN
- TRIM25
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- VISA
- ZNF147
- rep
- sM
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|
IRAK2 mediated activation of TAK1 complex
|
|
|
- IRAK2
- KIAA0733
- MAP3K7
- MAP3K7IP1
- MAP3K7IP2
- MAP3K7IP3
- RNF85
- RPS27A
- TAB1
- TAB2
- TAB3
- TAK1
- TRAF6
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
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|
activated TAK1 mediates p38 MAPK activation
|
|
|
- BLU
- CARD15
- CARD4
- CARDIAK
- CROC1
- CSBP
- CSBP1
- CSBP2
- CSPB1
- FIP3
- IKBKG
- IRAK
- IRAK1
- IRAK2
- KIAA0733
- MAP2K3
- MAP2K6
- MAP3K7
- MAP3K7IP1
- MAP3K7IP2
- MAP3K7IP3
- MAPK11
- MAPK14
- MAPKAPK2
- MAPKAPK3
- MEK3
- MEK6
- MKK3
- MKK6
- MXI2
- NEMO
- NOD1
- NOD2
- PRKM11
- PRKMK3
- PRKMK6
- RICK
- RIP2
- RIPK2
- RNF85
- SAPK2
- SAPK2A
- SAPK2B
- SKK2
- SKK3
- TAB1
- TAB2
- TAB3
- TAK1
- TRAF6
- UBE2N
- UBE2V
- UBE2V1
- UEV1
|
|
Invadopodia formation
|
|
|
- ADAM12
- ADAM15
- ADAM19
- FISH
- KIAA0418
- MDC15
- MLTN
- MLTNB
- SH3MD1
- SH3PXD2A
- TKS5
|
|
RA biosynthesis pathway
|
|
|
- ADH1
- ADH1A
- ADH1C
- ADH2
- ADH3
- ADH4
- AKR1C3
- ALDC
- ALDH1
- ALDH12
- ALDH1A1
- ALDH1A2
- ALDH1A3
- ALDH6
- ALDH8A1
- ARSDR1
- CRABP1
- CYP26
- CYP26A1
- CYP26A2
- CYP26B1
- CYP26C1
- DDH1
- DHRS3
- DHRS4
- DHRS9
- HSD17B5
- HSD17B9
- KIAA0119
- P450RAI1
- P450RAI2
- PAN2
- PGFS
- PSDR1
- PUMB1
- RALDH2
- RBP5
- RDH1
- RDH10
- RDH11
- RDH13
- RDH14
- RDH15
- RDH16
- RDH17
- RDH5
- RDHE2
- RODH4
- SDR16C1
- SDR16C4
- SDR16C5
- SDR25C2
- SDR7C1
- SDR7C3
- SDR7C4
- SDR9C4
- SDR9C5
- SDR9C8
|
|
N-Glycan antennae elongation
|
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
- Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
- Alpha-2,8-sialyltransferase 8B
- Alpha-2,8-sialyltransferase 8F
- Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3
- Beta-1,4-galactosyltransferase 1
- Beta-1,4-galactosyltransferase 2
- Beta-1,4-galactosyltransferase 3
- Beta-1,4-galactosyltransferase 4
- Beta-1,4-galactosyltransferase 5
- Beta-1,4-galactosyltransferase 6
- Beta-galactoside alpha-2,6-sialyltransferase 1
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
|
|
- B4GALT1
- B4GALT2
- B4GALT3
- B4GALT4
- B4GALT5
- B4GALT6
- CGS23
- GGNT5
- GGTB2
- MGAT4A
- MGAT4B
- MGAT4C
- MGAT5
- NANTA3
- SIAT1
- SIAT4C
- SIAT8B
- SIAT8C
- SIAT8F
- ST3GAL4
- ST6GAL1
- ST8SIA2
- ST8SIA3
- ST8SIA6
- STX
- STZ
|
|
SIRT1 negatively regulates rRNA expression
|
|
|
- GTF2D1
- H2AB1
- H2AC14
- H2AC18
- H2AC19
- H2AC20
- H2AC4
- H2AC6
- H2AC7
- H2AC8
- H2AFA
- H2AFB1
- H2AFE
- H2AFG
- H2AFJ
- H2AFL
- H2AFM
- H2AFO
- H2AFQ
- H2AFV
- H2AFX
- H2AJ
- H2AV
- H2AX
- H2AZ2
- H2BC1
- H2BC10
- H2BC11
- H2BC12
- H2BC12L
- H2BC13
- H2BC14
- H2BC15
- H2BC17
- H2BC21
- H2BC26
- H2BC3
- H2BC4
- H2BC5
- H2BC6
- H2BC7
- H2BC8
- H2BC9
- H2BFA
- H2BFB
- H2BFC
- H2BFD
- H2BFE
- H2BFF
- H2BFG
- H2BFH
- H2BFJ
- H2BFK
- H2BFL
- H2BFN
- H2BFQ
- H2BFR
- H2BFS
- H2BFT
- H2BS1
- H2BU1
- H3-3A
- H3-3B
- H3.3A
- H3.3B
- H3C1
- H3C10
- H3C11
- H3C12
- H3C13
- H3C14
- H3C15
- H3C2
- H3C3
- H3C4
- H3C6
- H3C7
- H3C8
- H3F2
- H3F3
- H3F3A
- H3F3B
- H3FA
- H3FB
- H3FC HIST1H3C
- H3FD
- H3FF
- H3FH
- H3FI
- H3FJ
- H3FK
- H3FL
- H3FM
- H4-16
- H4/A
- H4/B
- H4/C
- H4/D
- H4/E
- H4/G
- H4/H
- H4/I
- H4/J
- H4/K
- H4/M
- H4/N
- H4/O
- H4C1
- H4C11
- H4C12
- H4C13
- H4C14
- H4C15
- H4C16
- H4C2
- H4C3
- H4C4
- H4C5
- H4C6
- H4C8
- H4C9
- H4F2
- H4FA
- H4FB
- H4FC
- H4FD
- H4FE
- H4FG
- H4FH
- H4FI
- H4FJ
- H4FK
- H4FM
- H4FN
- H4FO
- HIRIP1
- HIRIP2
- HIST1H2AB
- HIST1H2AC
- HIST1H2AD
- HIST1H2AE
- HIST1H2AJ
- HIST1H2BA
- HIST1H2BB
- HIST1H2BC
- HIST1H2BD
- HIST1H2BE
- HIST1H2BF
- HIST1H2BG
- HIST1H2BH
- HIST1H2BI
- HIST1H2BJ
- HIST1H2BK
- HIST1H2BL
- HIST1H2BM
- HIST1H2BN
- HIST1H2BO
- HIST1H3A
- HIST1H3B
- HIST1H3D
- HIST1H3E
- HIST1H3F
- HIST1H3G
- HIST1H3H
- HIST1H3I
- HIST1H3J
- HIST1H4A
- HIST1H4B
- HIST1H4C
- HIST1H4D
- HIST1H4E
- HIST1H4F
- HIST1H4H
- HIST1H4I
- HIST1H4J
- HIST1H4K
- HIST1H4L
- HIST2H2AA
- HIST2H2AA3
- HIST2H2AA4
- HIST2H2AC
- HIST2H2BE
- HIST2H3A
- HIST2H3C
- HIST2H3D
- HIST2H4
- HIST2H4A
- HIST2H4B
- HIST3H2BB
- HIST4H4
- JOSD3
- KIAA0409
- KMT1A
- NML
- RRP8
- SIR2L1
- SIRT1
- SUV39H
- SUV39H1
- TAF1A
- TAF1B
- TAF1C
- TAF1D
- TBP
- TF2D
- TFIID
- TSH2B
|
|
Sema4D mediated inhibition of cell attachment and migration
|
|
|
- ARH12
- ARHA
- ARHGAP35
- C9orf164
- CD100
- GRF1
- GRLF1
- KIAA0407
- KIAA1722
- MET
- P190A
- PLXN5
- PLXNB1
- RAC1
- RHO12
- RHO6
- RHOA
- RND1
- RRAS
- SEMA4D
- SEMAJ
- SEP
- TC25
- p190ARHOGAP
|
|
Oxidative demethylation of DNA
|
|
|
- CXXC6
- KIAA0401
- KIAA1546
- KIAA1676
- LCX
- TDG
- TET1
- TET2
- TET3
|
|
Modulation by Mtb of host immune system
|
|
|
- B2M
- CLEC13D
- CLEC13DL
- MRC1
- MRC1L1
- RPS27A
- Rv2779c
- TIL4
- TLR2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- esaT6
- esxA
- mptpA
- phoS1
- pstS1
- ptpA
|
|
Ca activated K+ channels
|
|
|
- IK1
- IKCA1
- K3
- KCA4
- KCNMA
- KCNMA1
- KCNMB1
- KCNMB2
- KCNMB3
- KCNMB4
- KCNMBL
- KCNN1
- KCNN2
- KCNN3
- KCNN4
- SK
- SK4
- SLO
|
|
The NLRP3 inflammasome
|
|
|
- A4
- AD1
- APP
- ASC
- C1orf7
- CARD5
- CASP1
- CD2BP1
- CIAS1
- HMOX1
- HO
- HO1
- HSP90AB1
- HSP90B
- HSPC2
- HSPC3
- HSPCB
- IL1BC
- IL1BCE
- LYT10
- MEF
- MEFV
- MRS1
- NALP3
- NFKB1
- NFKB2
- NFKB3
- NLRP3
- P2RX7
- PANX1
- PSTPIP1
- PYCARD
- PYPAF1
- RELA
- SUGT1
- TMS1
- TRDX
- TRIM20
- TRX
- TRX1
- TXN
- TXNIP
- VDUP1
- hla
- hly
|
|
Purinergic signaling in leishmaniasis infection
|
|
|
- ASC
- AZ3B
- C1orf7
- C3
- C3AR1
- C3R1
- CARD5
- CASP1
- CD2BP1
- CD39
- CD39L4
- CIAS1
- CPAMD1
- CTSG
- DFNA5L
- ENTPD1
- ENTPD5
- GSDMD
- GSDMDC1
- HMOX1
- HNFAG09
- HO
- HO1
- HSP90AB1
- HSP90B
- HSPC2
- HSPC3
- HSPCB
- IGIF
- IL18
- IL1A
- IL1B
- IL1BC
- IL1BCE
- IL1F1
- IL1F2
- IL1F4
- LYT10
- MEF
- MEFV
- NALP3
- NFKB1
- NFKB2
- NFKB3
- NLRP3
- NT5
- NT5E
- NTE
- P2RX4
- P2RX7
- PCPH
- PSTPIP1
- PYCARD
- PYPAF1
- RELA
- SUGT1
- TMS1
- TRDX
- TRIM20
- TRX
- TRX1
- TXN
- TXNIP
- VDUP1
|
|
Platelet homeostasis
|
|
|
- P2RX1
- P2RX2
- P2RX3
- P2RX4
- P2RX5
- P2RX6
- P2RX7
- P2RXL1
- P2X1
- P2X2
- P2X5
- P2X5FL
- P2X6
- PAFAH2
|
|
Elevation of cytosolic Ca2+ levels
|
|
|
- C7orf19
- CBCIP2
- CRACM1
- GOK
- INSP3R1
- ITPR1
- ITPR2
- ITPR3
- ORAI1
- ORAI2
- P2RX1
- P2RX2
- P2RX3
- P2RX4
- P2RX5
- P2RX6
- P2RX7
- P2RXL1
- P2X1
- P2X2
- P2X5
- P2X5FL
- P2X6
- STIM1
- TMEM142A
- TMEM142B
- TRP3
- TRP6
- TRP7
- TRPC3
- TRPC6
- TRPC7
|
|
NOTCH3 Intracellular Domain Regulates Transcription
|
|
|
- BHLHB31
- BHLHB32
- BHLHB33
- BHLHB38
- BHLHB39
- BLBP
- CBP
- CG1
- CHF1
- CHF2
- CREBBP
- CXorf6
- DLG7
- DLGAP5
- EP300
- FABP7
- FABPB
- GCN5
- GCN5L2
- GRL
- HERP
- HERP1
- HERP2
- HES1
- HES5
- HESR1
- HEY1
- HEY2
- HEYL
- HL
- HRT1
- HRT2
- HRT3
- HRY
- IGKJRB
- IGKJRB1
- KAT2A
- KAT2B
- KIAA0008
- KIAA0200
- KIAA0620
- KIAA0869
- KIAA1816
- KIAA1819
- KIBRA
- MAML1
- MAML2
- MAML3
- MAMLD1
- MRG
- NOTCH1
- NOTCH3
- P300
- PBX1
- PCAF
- PLXND1
- PRL
- PTCRA
- RBPJ
- RBPJK
- RBPSUH
- SKIIP
- SKIP
- SNW1
- STAT1
- TAN1
- WWC1
|
|
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
|
|
|
- 8
- ABCB2
- ABCB3
- APPILS
- ARTS1
- ATG14
- ATG14L
- B2M
- BECN1
- CALR
- CANX
- CRTC
- D3S1231E
- ERAP1
- ERAP2
- ERP57
- ERP60
- GRP58
- GRP78
- GT197
- HLA-5.4
- HLA-6.0
- HLA-6.2
- HLA-A
- HLA-B
- HLA-C
- HLA-E
- HLA-F
- HLA-G
- HLA-H
- HLAA
- HLAB
- HLAC
- HLAE
- HLAF
- HLAG
- HLAH
- HSPA5
- KIAA0079
- KIAA0525
- KIAA0755
- KIAA0831
- KIAA0905
- LRAP
- NGS17
- PDIA3
- PIK3C3
- PIK3R4
- PSF1
- PSF2
- RING11
- RING4
- SAR1B
- SARA2
- SARB
- SEC13
- SEC13A
- SEC13L1
- SEC13R
- SEC23A
- SEC24A
- SEC24B
- SEC24C
- SEC24D
- SEC31A
- SEC31L1
- TAP1
- TAP2
- TAPA
- TAPBP
- VPS15
- VPS34
- Y1
- Y3
|
|
Activation of PKB
|
|
|
- AKT2
- C20orf97
- CTMP
- NIPK
- PDK1
- PDPK1
- SKIP3
- THEM4
- TRB3
- TRIB3
|
|
RSK activation
|
|
|
- ERK1
- ERK2
- ISPK1
- MAPK1
- MAPK3
- MAPKAPK1A
- MAPKAPK1B
- MAPKAPK1C
- PDK1
- PDPK1
- PRKM1
- PRKM2
- PRKM3
- RPS6KA1
- RPS6KA2
- RPS6KA3
- RPS6KA6
- RSK1
- RSK2
- RSK3
- RSK4
|
|
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
|
|
|
- 3a
- AKT1
- AKT2
- AKT3
- CAV
- CAV1
- HME1
- M
- N
- PDK1
- PDPK1
- PKB
- PKBG
- RAC
- SFN
- YWHA1
- YWHAB
- YWHAE
- YWHAG
- YWHAH
- YWHAQ
- YWHAZ
|
|
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
|
|
|
- 3a
- CAV
- CAV1
- DPC4
- EP300
- HME1
- M
- MADH3
- MADH4
- N
- P300
- PDK1
- PDPK1
- PSMC6
- SFN
- SMAD3
- SMAD4
- SP1
- SUG2
- TSFP1
- UBC9
- UBCE9
- UBE2I
- YWHA1
- YWHAB
- YWHAE
- YWHAG
- YWHAH
- YWHAQ
- YWHAZ
|
|
Estrogen-stimulated signaling through PRKCZ
|
|
|
- ERK2
- HRAS
- HRAS1
- MAPK1
- NRAS
- PDK1
- PDPK1
- PKC2
- PRKCZ
- PRKM1
- PRKM2
|
|