GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **2001 - 2025** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Impaired BRCA2 translocation to the nucleus	26S proteasome complex subunit SEM1 Breast cancer type 2 susceptibility protein	P51587 P60896	BRCA2 C7orf76 DSS1 FACD FANCD1 SEM1 SHFDG1 SHFM1	Homo sapiens (human)
CHL1 interactions	Ankyrin-1 Contactin-6 Heat shock cognate 71 kDa protein Integrin alpha-10 Integrin alpha-1 Integrin alpha-2 Integrin beta-1 Neural cell adhesion molecule L1-like protein Neuropilin-1	O00533 O14786 O75578 P05556 P11142 P16157 P17301 P56199 Q9UQ52	ANK ANK1 CALL CD49B CHL1 CNTN6 FNRB HSC70 HSP73 HSPA10 HSPA8 ITGA1 ITGA10 ITGA2 ITGB1 MDF2 MSK12 NRP NRP1 VEGF165R	Homo sapiens (human)
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	Sodium-dependent phosphate transporter 2	Q08357	GLVR2 PIT2 SLC20A2	Homo sapiens (human)
NTF3 activates NTRK2 (TRKB) signaling	BDNF/NT-3 growth factors receptor Neurotrophin-3	P20783 Q16620	NTF3 NTRK2 TRKB	Homo sapiens (human)
TRP channels	Mucolipin-1 Mucolipin-2 Mucolipin-3 Short transient receptor potential channel 1 Short transient receptor potential channel 3 Short transient receptor potential channel 4-associated protein Short transient receptor potential channel 4 Short transient receptor potential channel 5 Short transient receptor potential channel 6 Short transient receptor potential channel 7 Transient receptor potential cation channel subfamily A member 1 Transient receptor potential cation channel subfamily M member 1 Transient receptor potential cation channel subfamily M member 2 Transient receptor potential cation channel subfamily M member 3 Transient receptor potential cation channel subfamily M member 4 Transient receptor potential cation channel subfamily M member 5 Transient receptor potential cation channel subfamily M member 6 Transient receptor potential cation channel subfamily M member 7 Transient receptor potential cation channel subfamily M member 8 Transient receptor potential cation channel subfamily V member 1 Transient receptor potential cation channel subfamily V member 2 Transient receptor potential cation channel subfamily V member 3 Transient receptor potential cation channel subfamily V member 4 Transient receptor potential cation channel subfamily V member 5 Transient receptor potential cation channel subfamily V member 6	O75762 O94759 P48995 Q13507 Q7Z2W7 Q7Z4N2 Q8IZK6 Q8NER1 Q8NET8 Q8TD43 Q8TDD5 Q8TEL6 Q96QT4 Q9BX84 Q9GZU1 Q9H1D0 Q9HBA0 Q9HCF6 Q9HCX4 Q9NQA5 Q9NZQ8 Q9UBN4 Q9UL62 Q9Y210 Q9Y5S1	ANKTM1 C20orf188 CHAK1 CHAK2 ECAC1 ECAC2 EREG1 KIAA1616 KNP3 LTRPC1 LTRPC2 LTRPC3 LTRPC4 LTRPC5 LTRPC6 LTRPC7 MCOLN1 MCOLN2 MCOLN3 ML4 MLSN MLSN1 MTR1 TRP1 TRP3 TRP5 TRP6 TRP7 TRPA1 TRPC1 TRPC3 TRPC4 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8 TRPML1 TRPP8 TRPV1 TRPV2 TRPV3 TRPV4 TRPV5 TRPV6 TRRP4AP VR1 VRL VRL2 VROAC	Homo sapiens (human)
RHOBTB3 ATPase cycle	Cullin-3 G1/S-specific cyclin-E1 Hepatocyte growth factor-regulated tyrosine kinase substrate Leucine-rich repeat-containing protein 41 Perilipin-3 Ras-related protein Rab-9A Ras-related protein Rab-9B Rho-related BTB domain-containing protein 3 von Hippel-Lindau disease tumor suppressor	O14964 O60664 O94955 P24864 P40337 P51151 Q13618 Q15345 Q9NP90	CCNE CCNE1 CUL3 HGS HRS KIAA0617 KIAA0878 LRRC41 M6PRBP1 MUF1 PLIN3 RAB9 RAB9A RAB9B RAB9L RHOBTB3 TIP47 VHL	Homo sapiens (human)
Coenzyme A biosynthesis	Bifunctional coenzyme A synthase Dephospho-CoA kinase domain-containing protein Pantothenate kinase 1 Pantothenate kinase 2, mitochondrial Pantothenate kinase 3 Phosphopantothenate--cysteine ligase Phosphopantothenoylcysteine decarboxylase	Q13057 Q8TE04 Q8WVC6 Q96CD2 Q9BZ23 Q9H999 Q9HAB8	C20orf48 COAB COAC COASY DCAKD PANK PANK1 PANK2 PANK3 PPCDC PPCS	Homo sapiens (human)
Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)	Solute carrier organic anion transporter family member 1B3	Q9NPD5	LST2 OATP1B3 OATP8 SLC21A8 SLCO1B3	Homo sapiens (human)
Histamine receptors	Histamine H1 receptor Histamine H2 receptor Histamine H3 receptor Histamine H4 receptor	P25021 P35367 Q9H3N8 Q9Y5N1	GPCR105 GPCR97 HRH1 HRH2 HRH3 HRH4	Homo sapiens (human)
Signaling by Erythropoietin	Erythropoietin receptor Erythropoietin Insulin receptor substrate 2 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn	O60674 P01588 P07948 P19235 Q9Y4H2	EPO EPOR IRS2 JAK2 JTK8 LYN	Homo sapiens (human)
Resolution of D-loop Structures through Holliday Junction Intermediates	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein Crossover junction endonuclease EME1 Crossover junction endonuclease MUS81 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA repair-scaffolding protein DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 FIGNL1-interacting regulator of recombination and mitosis Fanconi anemia group J protein Fidgetin-like protein 1 Flap endonuclease GEN homolog 1 Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 Probable crossover junction endonuclease EME2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM Structure-specific endonuclease subunit SLX1 Structure-specific endonuclease subunit SLX4	A4GXA9 O15315 O43502 O43542 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14159 Q14191 Q17RS7 Q6PIW4 Q86YC2 Q8IY92 Q92878 Q92993 Q96AY2 Q96B01 Q96E14 Q96NY9 Q99708 Q99728 Q9BQ83 Q9BX63 Q9H9A7 Q9NSG2 Q9UQ84	APOLO1 ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 BTBD12 C16orf75 C1orf112 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EME1 EME2 EXO1 EXOI FACD FANCD1 FANCJ FANCN FIGNL1 FIRRM GEN1 GIYD1 GIYD2 HEX1 HNGS1 HTATIP KAT5 KIAA0083 KIAA0146 KIAA1784 KIAA1987 MMS4 MRE11 MRE11A MUS81 NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 SLX1 SLX1A SLX1B SLX4 SPIDR TIP60 TOP3 TOP3A WRN XRCC2 XRCC3	Homo sapiens (human)
AXIN missense mutants destabilize the destruction complex	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Glycogen synthase kinase-3 beta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O15169 P25054 P30153 P30154 P48729 P49841 P62714 P67775 Q13362 Q14738 Q15172 Q15173 Q16537 Q5JTC6	AMER1 APC AXIN AXIN1 CSNK1A1 DP2.5 FAM123B GSK3B KIAA0044 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WTX	Homo sapiens (human)
Transport of nucleotide sugars	Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Adenosine 3'-phospho 5'-phosphosulfate transporter 2 CMP-sialic acid transporter GDP-fucose transporter 1 Nucleotide sugar transporter SLC35B4 Nucleotide sugar transporter SLC35D1 Nucleotide sugar transporter SLC35D2 UDP-N-acetylglucosamine transporter UDP-galactose translocator	P78381 P78382 Q76EJ3 Q8TB61 Q969S0 Q96A29 Q9H1N7 Q9NTN3 Q9Y2D2	C6orf196 FUCT1 HFRC KIAA0260 PAPST1 PAPST2 SLC35A1 SLC35A2 SLC35A3 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35D1 SLC35D2 UGALT UGT UGTL UGTREL7 UGTREL8 YEA4	Homo sapiens (human)
Ethanol oxidation	Acetyl-coenzyme A synthetase 2-like, mitochondrial Acetyl-coenzyme A synthetase, cytoplasmic Alcohol dehydrogenase 1A Alcohol dehydrogenase 1C Alcohol dehydrogenase 6 Alcohol dehydrogenase class-3 Aldehyde dehydrogenase 1A1 Aldehyde dehydrogenase X, mitochondrial Aldehyde dehydrogenase, mitochondrial All-trans-retinol dehydrogenase [NAD(+)] ADH1B All-trans-retinol dehydrogenase [NAD(+)] ADH4 All-trans-retinol dehydrogenase [NAD(+)] ADH7	P00325 P00326 P00352 P05091 P07327 P08319 P11766 P28332 P30837 P40394 Q9NR19 Q9NUB1	ACAS2 ACAS2L ACSS1 ACSS2 ADH1 ADH1A ADH1B ADH1C ADH2 ADH3 ADH4 ADH5 ADH6 ADH7 ADHX ALDC ALDH1 ALDH1A1 ALDH1B1 ALDH2 ALDH5 ALDHX ALDM FDH KIAA1846 PUMB1	Homo sapiens (human)
CD22 mediated BCR regulation	B-cell antigen receptor complex-associated protein alpha chain B-cell antigen receptor complex-associated protein beta chain B-cell receptor CD22 IGHV7-81 protein Immunoglobulin heavy constant delta Immunoglobulin heavy constant mu Immunoglobulin heavy variable 1-2 Immunoglobulin heavy variable 1-46 Immunoglobulin heavy variable 1-69 Immunoglobulin heavy variable 2-5 Immunoglobulin heavy variable 2-70 Immunoglobulin heavy variable 3-11 Immunoglobulin heavy variable 3-13 Immunoglobulin heavy variable 3-23 Immunoglobulin heavy variable 3-30 Immunoglobulin heavy variable 3-33 Immunoglobulin heavy variable 3-48 Immunoglobulin heavy variable 3-53 Immunoglobulin heavy variable 3-7 Immunoglobulin heavy variable 3-9 Immunoglobulin heavy variable 4-34 Immunoglobulin heavy variable 4-39 Immunoglobulin heavy variable 4-59 Immunoglobulin kappa constant Immunoglobulin kappa variable 1-12 Immunoglobulin kappa variable 1-16 Immunoglobulin kappa variable 1-17 Immunoglobulin kappa variable 1-33 Immunoglobulin kappa variable 1-39 Immunoglobulin kappa variable 1-5 Immunoglobulin kappa variable 1D-12 Immunoglobulin kappa variable 1D-16 Immunoglobulin kappa variable 1D-33 Immunoglobulin kappa variable 1D-39 Immunoglobulin kappa variable 2-28 Immunoglobulin kappa variable 2-29 Immunoglobulin kappa variable 2-30 Immunoglobulin kappa variable 2D-28 Immunoglobulin kappa variable 2D-30 Immunoglobulin kappa variable 2D-40 Immunoglobulin kappa variable 3-11 Immunoglobulin kappa variable 3-15 Immunoglobulin kappa variable 3-20 Immunoglobulin kappa variable 3D-20 Immunoglobulin kappa variable 4-1 Immunoglobulin kappa variable 5-2 Immunoglobulin lambda constant 1 Immunoglobulin lambda constant 2 Immunoglobulin lambda constant 3 Immunoglobulin lambda constant 6 Immunoglobulin lambda constant 7 Immunoglobulin lambda variable 1-40 Immunoglobulin lambda variable 1-44 Immunoglobulin lambda variable 1-47 Immunoglobulin lambda variable 1-51 Immunoglobulin lambda variable 2-11 Immunoglobulin lambda variable 2-14 Immunoglobulin lambda variable 2-23 Immunoglobulin lambda variable 2-8 Immunoglobulin lambda variable 3-19 Immunoglobulin lambda variable 3-1 Immunoglobulin lambda variable 3-21 Immunoglobulin lambda variable 3-25 Immunoglobulin lambda variable 3-27 Immunoglobulin lambda variable 6-57 Immunoglobulin lambda variable 7-43 Immunolglobulin kappa light chain variable region L22 (Fragment) Tyrosine-protein kinase Lyn Tyrosine-protein phosphatase non-receptor type 6 UGa8H (Fragment)	A0A075B6P5 A0A075B6S6 A0A0C4DH25 A0A0C4DH73 A0M8Q6 A2KUC3 A2NJV5 A2NXD2 P01593 P01594 P01597 P01599 P01601 P01602 P01611 P01614 P01615 P01619 P01624 P01699 P01700 P01701 P01703 P01704 P01705 P01706 P01709 P01714 P01715 P01717 P01718 P01721 P01742 P01743 P01762 P01763 P01764 P01766 P01767 P01768 P01772 P01780 P01782 P01814 P01817 P01824 P01825 P01834 P01871 P01880 P04211 P04430 P04432 P04433 P06310 P06312 P06315 P06331 P07948 P0CF74 P0CG04 P0DOY2 P0DOY3 P11912 P20273 P23083 P29350 P40259 P80748 Q6PIL0	B29 CD22 CD79A CD79B HCP IGA IGB IGHD IGHM IGHV IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGHV7-81 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 JTK8 LYN MB1 PTP1C PTPN6 SIGLEC2	Homo sapiens (human)
PI3K/AKT Signaling	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Amphiregulin B-lymphocyte antigen CD19 BDNF/NT-3 growth factors receptor Beta-klotho Brain-derived neurotrophic factor Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-like 1 Interleukin-33 Mast/stem cell growth factor receptor Kit Membrane protein Myeloid differentiation primary response protein MyD88 NT-3 growth factor receptor Neurotrophin-3 Neurotrophin-4 Nucleoprotein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphoinositide 3-kinase adapter protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proline-rich protein 5 Proto-oncogene tyrosine-protein kinase Src Proto-oncogene vav Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Rho-related GTP-binding protein RhoG Serine/threonine-protein kinase Sgk1 Serine/threonine-protein kinase mTOR Striatin T-cell receptor-associated transmembrane adapter 1 T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 TNF receptor-associated factor 6 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein phosphatase non-receptor type 11	O00141 O00329 O00459 O14511 O14944 O15520 O15530 O43320 O43815 O76093 O95750 O95760 P00533 P01127 P01133 P01135 P03372 P04626 P05230 P06239 P06241 P08581 P08620 P09038 P09619 P0DTC5 P0DTC9 P10721 P10747 P10767 P11487 P12931 P14210 P15153 P15391 P15498 P15514 P16234 P20783 P21781 P22455 P23560 P27986 P31371 P31749 P31751 P33681 P34130 P35070 P35568 P36888 P42081 P42336 P42338 P42345 P49771 P51617 P56975 P63000 P84095 P85299 Q01638 Q02297 Q06124 Q13480 Q16288 Q16620 Q5T1C6 Q6PIZ9 Q6R327 Q6UW88 Q6ZUJ8 Q86Z14 Q8WU20 Q8WWG1 Q92569 Q92731 Q96RU7 Q99075 Q99836 Q9BPZ7 Q9BVC4 Q9GZV9 Q9HCT0 Q9NP95 Q9NWZ3 Q9UQC2 Q9Y243 Q9Y4H2 Q9Y4K3	AKT1 AKT2 AKT3 AREG AREGB ARHG BCAP BDNF BTC C20orf97 C9orf26 CD135 CD19 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 CTMP DER4 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ESR ESR1 ESR2 ESTRB FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRAP FRAP1 FRAP2 FRS2 FYN GAB1 GAB2 GBL GGF GRB1 HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRGA HST HST2 HSTF1 HSTF2 HYPF IL1F11 IL1RL1 IL33 INT2 IRAK IRAK1 IRAK4 IRS1 IRS2 JTK2 KGF KIAA0571 KIAA1999 KIT KLB KS3 LAB7 LCK LST8 M MAPKAP1 MET MIP1 MLN19 MLST8 MTOR MYD88 N NDF NEU NFHEV NGL NIPK NR3A1 NR3A2 NRG1 NRG2 NRG3 NRG4 NTAK NTF3 NTF4 NTF5 NTRK2 NTRK3 PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PDK1 PDPK1 PIK3AP1 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PKB PKBG PROTOR1 PRR5 PTP2C PTPN11 RAC RAC1 RAC2 RAFT1 RAPT1 RHEPDGFRA RHOG RICTOR RNF85 SCFR SDGF SGK SGK1 SHPTP2 SIN1 SIS SKIP3 SMDF SRC SRC1 ST2 STK1 STRN T1 TC25 TCRIM TGFA THEM4 TKF TRAF6 TRAT1 TRB3 TRIB3 TRKB TRKC VAV VAV1	Homo sapiens (human)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	Cell division cycle protein 20 homolog Mitotic spindle assembly checkpoint protein MAD2A	Q12834 Q13257	CDC20 MAD2 MAD2L1	Homo sapiens (human)
RHOJ GTPase cycle	ADP-ribosylation factor-like protein 13B ARF GTPase-activating protein GIT1 ARF GTPase-activating protein GIT2 Actin nucleation-promoting factor WAS Actin nucleation-promoting factor WASL Caveolin-1 Cdc42 effector protein 1 Cell division control protein 42 homolog Copine-8 DEP domain-containing protein 1B Dedicator of cytokinesis protein 8 Formin-binding protein 1-like Formin-binding protein 1 Formin-like protein 3 Gap junction alpha-1 protein Inositol polyphosphate 5-phosphatase OCRL Junction plakoglobin Lamina-associated polypeptide 2, isoforms beta/gamma MAGUK p55 subfamily member 7 Metalloreductase STEAP3 NEDD4-like E3 ubiquitin-protein ligase WWP2 Neutral amino acid transporter B(0) Oligophrenin-1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Protein NipSnap homolog 2 Protein diaphanous homolog 3 Protein scribble homolog Ragulator complex protein LAMTOR1 Ras GTPase-activating-like protein IQGAP3 Ras-related protein Rab-7a Rho GTPase-activating protein 1 Rho GTPase-activating protein 21 Rho GTPase-activating protein 26 Rho GTPase-activating protein 32 Rho GTPase-activating protein 35 Rho GTPase-activating protein 5 Rho GTPase-activating protein SYDE1 Rho guanine nucleotide exchange factor 7 Rho-related GTP-binding protein RhoJ Serine/threonine-protein kinase MRCK alpha Serine/threonine-protein kinase MRCK beta Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase PAK 4 Sodium bicarbonate cotransporter 3 Stomatin Synaptosomal-associated protein 23 Transferrin receptor protein 1 Triple functional domain protein Vang-like protein 1 Vesicle-associated membrane protein 3 WAS/WASL-interacting protein family member 2	A7KAX9 O00161 O00308 O00401 O00459 O60890 O75323 O75914 O75962 O96013 P02786 P14923 P17302 P27105 P27986 P42167 P42768 P51149 P60953 Q00587 Q01968 Q03135 Q07960 Q13017 Q13153 Q13177 Q14155 Q14160 Q14161 Q15758 Q15836 Q3SXY8 Q5T0N5 Q5T2T1 Q5T5U3 Q5VT25 Q658P3 Q6IAA8 Q6ZW31 Q86VI3 Q86YQ8 Q8IVF7 Q8NF50 Q8TAA9 Q8TCU6 Q8TF74 Q8WUY9 Q96RU3 Q9H4E5 Q9NRY4 Q9NSV4 Q9UNA1 Q9Y2X7 Q9Y5S2 Q9Y6M7	ARHGAP1 ARHGAP10 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP5 ARHGEF7 ARHJ ARL13B ARL2L1 ASCT2 BND7 BORG5 BT C11orf59 C1orf39 CAV CAV1 CDC42 CDC42BPA CDC42BPB CDC42EP1 CDC42GAP CEP1 COOL1 CPNE8 CRIB1 CTNNG DEPDC1B DIAP3 DIAPH3 DOCK8 DP3 EPB72 FBP17 FHOD3 FMNL3 FNBP1 FNBP1L FRL2 GBAS GIT1 GIT2 GJA1 GJAL GRAF GRB1 GRF1 GRIT GRLF1 IMD2 IQGAP3 JUP KIAA0142 KIAA0147 KIAA0148 KIAA0451 KIAA0554 KIAA0621 KIAA0712 KIAA1124 KIAA1142 KIAA1415 KIAA1424 KIAA1722 KIAA2014 LAMTOR1 LAP2 LAP4 M7V1 MPP7 MSE55 NBC2 NBC2B NBC3 NBCn1 NIPSNAP2 OCRL OCRL1 OPHN1 OPHN1L OPHN3 P190A P85SPR PAK1 PAK2 PAK3 PAK3BP PAK4 PDRO PIK3R1 PIK3R2 PIXB PREX1 RAB7 RAB7A RASL7B RDR RDRC RHOGAP1 RHOGAP5 RHOI RHOJ RICS SBC2 SCRB1 SCRIB SLC1A5 SLC4A6 SLC4A7 SNAP23 STB2 STEAP3 STOM SYB3 SYDE1 TCL TFRC TMPO TOCA1 TRIO TSAP6 VAMP3 VANGL1 VARTUL WAS WASL WBP3 WICH WIPF2 WIRE WWP2 XTP8 p190ARHOGAP	Homo sapiens (human)
Norepinephrine Neurotransmitter Release Cycle	Amine oxidase [flavin-containing] A Complexin-1 Liprin-alpha-1 Liprin-alpha-2 Liprin-alpha-3 Liprin-alpha-4 Peripheral-type benzodiazepine receptor-associated protein 1 Protein unc-13 homolog B Ras-related protein Rab-3A Regulating synaptic membrane exocytosis protein 1 Solute carrier family 22 member 1 Solute carrier family 22 member 2 Synaptic vesicular amine transporter Synaptosomal-associated protein 25 Synaptotagmin-1 Syntaxin-1A Vesicle-associated membrane protein 2	O14795 O14810 O15244 O15245 O75145 O75334 O75335 O95153 P20336 P21397 P21579 P60880 P63027 Q05940 Q13136 Q16623 Q86UR5	BZRAP1 CPLX1 KIAA0340 KIAA0612 KIAA0654 KIAA0897 LIP1 MAOA OCT1 OCT2 PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RAB3IP2 RBP1 RIM1 RIMBP1 RIMS1 SLC18A2 SLC22A1 SLC22A2 SNAP SNAP25 STX1 STX1A SVMT SVP65 SYB2 SYT SYT1 TSPOAP1 UNC13 UNC13B VAMP2 VMAT2	Homo sapiens (human)
Voltage gated Potassium channels	A-type voltage-gated potassium channel KCND1 A-type voltage-gated potassium channel KCND2 A-type voltage-gated potassium channel KCND3 Potassium voltage-gated channel subfamily A member 10 Potassium voltage-gated channel subfamily A member 1 Potassium voltage-gated channel subfamily A member 2 Potassium voltage-gated channel subfamily A member 3 Potassium voltage-gated channel subfamily A member 4 Potassium voltage-gated channel subfamily A member 5 Potassium voltage-gated channel subfamily A member 6 Potassium voltage-gated channel subfamily A member 7 Potassium voltage-gated channel subfamily B member 1 Potassium voltage-gated channel subfamily B member 2 Potassium voltage-gated channel subfamily KQT member 1 Potassium voltage-gated channel subfamily KQT member 2 Potassium voltage-gated channel subfamily KQT member 3 Potassium voltage-gated channel subfamily KQT member 4 Potassium voltage-gated channel subfamily KQT member 5 Potassium voltage-gated channel subfamily S member 1 Potassium voltage-gated channel subfamily S member 2 Potassium voltage-gated channel subfamily S member 3 Potassium voltage-gated channel subfamily V member 1 Potassium voltage-gated channel subfamily V member 2 Voltage-gated delayed rectifier potassium channel KCNH1 Voltage-gated delayed rectifier potassium channel KCNH4 Voltage-gated delayed rectifier potassium channel KCNH5 Voltage-gated delayed rectifier potassium channel KCNH8 Voltage-gated inwardly rectifying potassium channel KCNH2 Voltage-gated inwardly rectifying potassium channel KCNH3 Voltage-gated inwardly rectifying potassium channel KCNH6 Voltage-gated inwardly rectifying potassium channel KCNH7 Voltage-gated potassium channel KCNC1 Voltage-gated potassium channel KCNC2 Voltage-gated potassium channel KCNC3 Voltage-gated potassium channel KCNC4 Voltage-gated potassium channel regulatory subunit KCNF1 Voltage-gated potassium channel regulatory subunit KCNG1 Voltage-gated potassium channel regulatory subunit KCNG2 Voltage-gated potassium channel regulatory subunit KCNG3 Voltage-gated potassium channel regulatory subunit KCNG4 Voltage-gated potassium channel subunit beta-1 Voltage-gated potassium channel subunit beta-2 Voltage-gated potassium channel subunit beta-3	O43448 O43525 O43526 O95259 P16389 P17658 P22001 P22459 P22460 P48547 P51787 P56696 Q03721 Q09470 Q12809 Q13303 Q14003 Q14721 Q14722 Q16322 Q6PIU1 Q8NCM2 Q8TAE7 Q8TDN1 Q8TDN2 Q92953 Q96KK3 Q96L42 Q96PR1 Q96RP8 Q9BQ31 Q9H252 Q9H3M0 Q9NR82 Q9NS40 Q9NSA2 Q9NZV8 Q9UIX4 Q9UJ96 Q9UK17 Q9ULD8 Q9ULS6 Q9UQ05	C1orf30 EAG EAG1 EAG2 ERG ERG1 ERG2 ERG3 HERG HGK5 KCNA1 KCNA10 KCNA1B KCNA2 KCNA2B KCNA3 KCNA3B KCNA4 KCNA4L KCNA5 KCNA6 KCNA7 KCNA8 KCNA9 KCNAB1 KCNAB2 KCNAB3 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNF2 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNK2 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 KIAA1044 KIAA1144 KIAA1282 KVLQT1	Homo sapiens (human)
Translocation of SLC2A4 (GLUT4) to the plasma membrane	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 C2 domain-containing protein 5 Calmodulin-1 Exocyst complex component 1 Exocyst complex component 2 Exocyst complex component 3 Exocyst complex component 4 Exocyst complex component 5 Exocyst complex component 6 Exocyst complex component 7 Exocyst complex component 8 Kinesin-associated protein 3 Kinesin-like protein KIF3A Kinesin-like protein KIF3B Leucyl-cystinyl aminopeptidase Myosin-9 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase Ral GTPase-activating protein subunit alpha-2 Ral GTPase-activating protein subunit beta Ras-related C3 botulinum toxin substrate 1 Ras-related protein Rab-10 Ras-related protein Rab-11A Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-4A Ras-related protein Rab-8A Ras-related protein Ral-A Rho-related GTP-binding protein RhoQ Solute carrier family 2, facilitated glucose transporter member 4 Synaptosomal-associated protein 23 Syntaxin-4 Syntaxin-binding protein 3 TBC1 domain family member 1 TBC1 domain family member 4 Tether containing UBX domain for GLUT4 Unconventional myosin-Ic Unconventional myosin-Va Vesicle-associated membrane protein 2	O00159 O00161 O00186 O00471 O15066 O43741 O60343 O60645 P0DP23 P11233 P14672 P17081 P20338 P27348 P31749 P31751 P31946 P31947 P35579 P51153 P54619 P54646 P61006 P61026 P61106 P61981 P62258 P62491 P63000 P63027 P63104 Q04917 Q12846 Q2PPJ7 Q86TI0 Q86X10 Q86YS7 Q8IYI6 Q8TAG9 Q92845 Q96A65 Q96KP1 Q9BZE9 Q9NV70 Q9UGI9 Q9UGJ0 Q9UIQ6 Q9UPT5 Q9Y478 Q9Y496 Q9Y4I1	AKT1 AKT2 AMPK AMPK2 AMPKG3 ARHQ AS160 ASPL ASPSCR1 C20orf74 C2CD5 CALM CALM1 CAM CAM1 CDP138 EXO70 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 GLUT4 HME1 KIAA0359 KIAA0528 KIAA0603 KIAA1067 KIAA1108 KIAA1219 KIAA1272 KIAA1699 KIF3 KIF3A KIF3AP KIF3B KIFAP3 LNPEP MEL MYH12 MYH9 MYO1C MYO5A OTASE PKB PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RAB10 RAB11 RAB11A RAB13 RAB14 RAB4 RAB4A RAB8 RAB8A RAC RAC1 RAL RALA RALGAPA2 RALGAPB RASL7A RCC17 RHOQ SEC10 SEC10L1 SEC15A SEC15L SEC15L1 SEC3 SEC3L1 SEC5 SEC5L1 SEC6 SEC6L1 SEC8 SEC8L1 SFN SLC2A4 SMAP SNAP23 STX4 STX4A STXBP3 SYB2 TBC1D1 TBC1D4 TC10 TC25 TUG UBXD9 UBXN9 VAMP2 YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	Homo sapiens (human)
Transcriptional Regulation by MECP2	Guanidinoacetate N-methyltransferase Helicase MOV-10 Interleukin-1 receptor-associated kinase 1 Microprocessor complex subunit DGCR8 Myelin-associated oligodendrocyte basic protein Parvalbumin alpha Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Protein argonaute-1 Protein argonaute-2 Protein argonaute-3 Protein argonaute-4 Serine/threonine-protein kinase Sgk1 Transcription factor SOX-2 Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein	O00141 P20472 P48431 P51617 P60484 Q13875 Q14353 Q8NDV7 Q8WYQ5 Q9H9G7 Q9HCE1 Q9HCJ0 Q9HCK5 Q9UKV8 Q9UL18 Q9UPQ9	AGO1 AGO2 AGO3 AGO4 C22orf12 CAGH26 DGCR8 DGCRK6 EIF2C1 EIF2C2 EIF2C3 EIF2C4 GAMT IRAK IRAK1 KIAA1093 KIAA1460 KIAA1567 KIAA1582 KIAA1631 MMAC1 MOBP MOV10 PTEN PVALB SGK SGK1 SOX2 TEP1 TNRC6 TNRC6A TNRC6B TNRC6C	Homo sapiens (human)
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	Potassium channel subfamily K member 1 Potassium channel subfamily K member 6 Potassium channel subfamily K member 7	O00180 Q9Y257 Q9Y2U2	HOHO1 KCNK1 KCNK6 KCNK7 KCNO1 TOSS TWIK1 TWIK2	Homo sapiens (human)
FGFR1b ligand binding and activation	Fibroblast growth factor 10 Fibroblast growth factor 1 Fibroblast growth factor 22 Fibroblast growth factor 2 Fibroblast growth factor 3 PDZ domain-containing protein GIPC1 Transforming growth factor beta receptor type 3	O14908 O15520 P05230 P09038 P11487 Q03167 Q9HCT0	C19orf3 FGF1 FGF10 FGF2 FGF22 FGF3 FGFA FGFB GIPC GIPC1 INT2 RGS19IP1 TGFBR3	Homo sapiens (human)
PI3K Cascade	Beta-klotho Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Insulin receptor substrate 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphoinositide 3-kinase regulatory subunit 4 Receptor-type tyrosine-protein kinase FLT3 Toll-like receptor 9 Tyrosine-protein phosphatase non-receptor type 11	O00459 O15520 O43320 O76093 O95750 P05230 P08620 P09038 P10767 P11487 P21781 P22455 P27986 P31371 P35568 P36888 P42336 P42338 P49771 Q06124 Q13480 Q86Z14 Q8NEB9 Q8WU20 Q99570 Q9GZV9 Q9HCT0 Q9NP95 Q9NR96 Q9UQC2 Q9Y4H2	CD135 FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 GAB1 GAB2 GRB1 HST HST2 HSTF1 HSTF2 HYPF INT2 IRS1 IRS2 JTK2 KGF KIAA0571 KLB KS3 PIK3C1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTP2C PTPN11 SHPTP2 STK1 TKF TLR9 VPS15 VPS34	Homo sapiens (human)

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