GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **1026 - 1050** of **2090** in total

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Pathway Name	Protein Name	UniProt ID ▼	Gene Symbol
NFE2L2 regulating ER-stress associated genes	CREB-binding protein Cyclic AMP-dependent transcription factor ATF-4 Histone acetyltransferase p300 Nuclear factor erythroid 2-related factor 2 Transcription factor MafK	O60675 P18848 Q09472 Q16236 Q92793	ATF4 CBP CREB2 CREBBP EP300 MAFK NFE2L2 NRF2 P300 TXREB
NFE2L2 regulating inflammation associated genes	C-C motif chemokine 2 CREB-binding protein Histone acetyltransferase p300 Nuclear factor erythroid 2-related factor 2 Transcription factor MafK	O60675 P13500 Q09472 Q16236 Q92793	CBP CCL2 CREBBP EP300 MAFK MCP1 NFE2L2 NRF2 P300 SCYA2
NFE2L2 regulating tumorigenic genes	Amphiregulin Apoptosis regulator Bcl-2 Bcl-2-like protein 1 CREB-binding protein Histone acetyltransferase p300 Neurogenic locus notch homolog protein 1 Nuclear factor erythroid 2-related factor 2 Platelet-derived growth factor subunit A Pro-epidermal growth factor Transcription factor MafK Transcription factor Sp1	O60675 P01133 P04085 P08047 P10415 P15514 P46531 Q07817 Q09472 Q16236 Q92793	AREG AREGB BCL2 BCL2L BCL2L1 BCLX CBP CREBBP EGF EP300 MAFK NFE2L2 NOTCH1 NRF2 P300 PDGF1 PDGFA SDGF SP1 TAN1 TSFP1
Regulation of NFE2L2 gene expression	CREB-binding protein Histone acetyltransferase p300 Myc proto-oncogene protein Neurogenic locus notch homolog protein 1 Nuclear factor NF-kappa-B p105 subunit Nuclear factor erythroid 2-related factor 2 Transcription factor MafK Transcription factor p65	O60675 P01106 P19838 P46531 Q04206 Q09472 Q16236 Q92793	BHLHE39 CBP CREBBP EP300 MAFK MYC NFE2L2 NFKB1 NFKB3 NOTCH1 NRF2 P300 RELA TAN1
Interleukin-20 family signaling	Interferon lambda receptor 1 Interferon lambda-1 Interferon lambda-2 Interferon lambda-3 Interleukin-10 receptor subunit beta Interleukin-19 Interleukin-20 receptor subunit alpha Interleukin-20 receptor subunit beta Interleukin-20 Interleukin-22 receptor subunit alpha-1 Interleukin-22 receptor subunit alpha-2 Interleukin-22 Interleukin-24 Interleukin-26 Non-receptor tyrosine-protein kinase TYK2 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 2 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 4 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3 Tyrosine-protein phosphatase non-receptor type 11	O60674 P23458 P29597 P40763 P42224 P42229 P51692 P52333 P52630 Q06124 Q08334 Q13007 Q14765 Q6UXL0 Q8IU54 Q8IU57 Q8IZI9 Q8IZJ0 Q8N6P7 Q969J5 Q9GZX6 Q9NPH9 Q9NYY1 Q9UHD0 Q9UHF4	AK155 APRF CRFB4 D21S58 D21S66 DIRS1 IFNL1 IFNL2 IFNL3 IFNLR1 IL10RB IL19 IL20 IL20RA IL20RB IL22 IL22R IL22RA1 IL22RA2 IL24 IL26 IL28A IL28B IL28C IL28RA IL29 ILTIF JAK1 JAK1A JAK1B JAK2 JAK3 LICR2 MDA7 PTP2C PTPN11 SHPTP2 ST16 STAT1 STAT2 STAT3 STAT4 STAT5 STAT5A STAT5B TYK2 ZCYTO10 ZCYTO18 ZCYTO20 ZCYTO21 ZCYTO22 ZMDA1
Interleukin-35 Signalling	Calnexin Interleukin-12 receptor subunit beta-2 Interleukin-12 subunit alpha Interleukin-27 receptor subunit alpha Interleukin-27 subunit beta Interleukin-6 receptor subunit beta Non-receptor tyrosine-protein kinase TYK2 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 4 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2	O60674 P23458 P27824 P29459 P29597 P40189 P40763 P42224 Q14213 Q14765 Q6UWB1 Q99665	APRF CANX CRL1 EBI3 IL12A IL12RB2 IL27B IL27RA IL6ST JAK1 JAK1A JAK1B JAK2 NKSF1 STAT1 STAT3 STAT4 TCCR TYK2 WSX1
Interleukin-23 signaling	Interleukin-12 receptor subunit beta-1 Interleukin-12 subunit beta Interleukin-23 receptor Interleukin-23 subunit alpha Non-receptor tyrosine-protein kinase TYK2 Protein disulfide-isomerase Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 4 Tyrosine-protein kinase JAK2	O60674 P07237 P29460 P29597 P40763 P42701 Q14765 Q5VWK5 Q9NPF7	APRF ERBA2L IL12B IL12R IL12RB IL12RB1 IL23A IL23R JAK2 NKSF2 P4HB PDI PDIA1 PO4DB SGRF STAT3 STAT4 TYK2
Interleukin-12 signaling	Interleukin-12 receptor subunit beta-1 Interleukin-12 receptor subunit beta-2 Interleukin-12 subunit alpha Interleukin-12 subunit beta Non-receptor tyrosine-protein kinase TYK2 Protein disulfide-isomerase Signal transducer and activator of transcription 4 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Vesicle-associated membrane protein 7	O60674 P07237 P23458 P29459 P29460 P29597 P42701 P51809 Q14765 Q99665	ERBA2L IL12A IL12B IL12R IL12RB IL12RB1 IL12RB2 JAK1 JAK1A JAK1B JAK2 NKSF1 NKSF2 P4HB PDI PDIA1 PO4DB STAT4 SYBL1 TYK2 VAMP7
MAPK1 (ERK2) activation	Dual specificity mitogen-activated protein kinase kinase 2 Interleukin-6 receptor subunit alpha Interleukin-6 Mitogen-activated protein kinase 1 Non-receptor tyrosine-protein kinase TYK2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 11	O60674 P05231 P08887 P23458 P28482 P29597 P36507 Q06124	ERK2 IFNB2 IL6 IL6R JAK1 JAK1A JAK1B JAK2 MAP2K2 MAPK1 MEK2 MKK2 PRKM1 PRKM2 PRKMK2 PTP2C PTPN11 SHPTP2 TYK2
MAPK3 (ERK1) activation	Cyclin-dependent kinase 1 Dual specificity mitogen-activated protein kinase kinase 1 Interleukin-6 receptor subunit alpha Interleukin-6 Mitogen-activated protein kinase 3 Non-receptor tyrosine-protein kinase TYK2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 11	O60674 P05231 P06493 P08887 P23458 P27361 P29597 Q02750 Q06124	CDC2 CDC28A CDK1 CDKN1 ERK1 IFNB2 IL6 IL6R JAK1 JAK1A JAK1B JAK2 MAP2K1 MAPK3 MEK1 P34CDC2 PRKM3 PRKMK1 PTP2C PTPN11 SHPTP2 TYK2
Signaling by Erythropoietin	Erythropoietin receptor Erythropoietin Insulin receptor substrate 2 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn	O60674 P01588 P07948 P19235 Q9Y4H2	EPO EPOR IRS2 JAK2 JTK8 LYN
Erythropoietin activates STAT5	Erythropoietin receptor Erythropoietin Insulin receptor substrate 2 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn	O60674 P01588 P07948 P19235 P42229 P51692 Q9Y4H2	EPO EPOR IRS2 JAK2 JTK8 LYN STAT5 STAT5A STAT5B
Erythropoietin activates Phospholipase C gamma (PLCG)	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Erythropoietin receptor Erythropoietin Insulin receptor substrate 2 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn	O60674 P01588 P07948 P16885 P19174 P19235 Q9Y4H2	EPO EPOR IRS2 JAK2 JTK8 LYN PLC1 PLCG1 PLCG2
IFNG signaling activates MAPKs	Interferon gamma receptor 1 Interferon gamma receptor 2 Interferon gamma Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 RAF proto-oncogene serine/threonine-protein kinase Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2	O60674 P01579 P04049 P15260 P23458 P27361 P28482 P38484	ERK1 ERK2 IFNG IFNGR1 IFNGR2 IFNGT1 JAK1 JAK1A JAK1B JAK2 MAPK1 MAPK3 PRKM1 PRKM2 PRKM3 RAF RAF1
Prolactin receptor signaling	Chorionic somatomammotropin hormone 1 Cullin-1 E3 ubiquitin-protein ligase RBX1 F-box/WD repeat-containing protein 1A Growth hormone receptor Growth hormone variant Prolactin receptor Prolactin S-phase kinase-associated protein 1 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Somatotropin Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 11	O60674 P01236 P01241 P01242 P0DML2 P10912 P16471 P42229 P51692 P62877 P63208 Q06124 Q13616 Q9Y297	BTRC BTRCP CSH1 CUL1 EMC19 FBW1A FBXW1A GH1 GH2 GHR JAK2 OCP2 PRL PRLR PTP2C PTPN11 RBX1 RNF75 ROC1 SHPTP2 SKP1 SKP1A STAT5 STAT5A STAT5B TCEB1L
Signaling by RAF1 mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Beta-arrestin-1 Beta-arrestin-2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 Vinculin von Willebrand factor	O60674 P01111 P01112 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P31946 P32121 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q6VAB6 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9UQM7 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 KIAA0051 KIAA0902 KIAA0968 KIAA1027 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 NRAS PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RIAM SRC SRC1 TLN TLN1 VCL VWF YWHAB
Erythropoietin activates RAS	Crk-like protein Erythropoietin receptor Erythropoietin GTPase HRas GTPase NRas Insulin receptor substrate 2 Proto-oncogene vav Rap guanine nucleotide exchange factor 1 SHC-transforming protein 1 Son of sevenless homolog 1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn	O60674 P01111 P01112 P01588 P07948 P15498 P19235 P29353 P46109 Q07889 Q13905 Q9Y4H2	CRKL EPO EPOR GRF2 HRAS HRAS1 IRS2 JAK2 JTK8 LYN NRAS RAPGEF1 SHC SHC1 SHCA SOS1 VAV VAV1
Signaling downstream of RAS mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein BRCA1-associated protein Beta-arrestin-1 Beta-arrestin-2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase KRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase kinase kinase 11 Phosphatidylethanolamine-binding protein 1 Prohibitin 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 Vinculin von Willebrand factor	O60674 P01111 P01112 P01116 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P35232 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q16584 Q6VAB6 Q7Z569 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9UQM7 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 BRAP CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 KIAA0051 KIAA0902 KIAA0968 KIAA1027 KRAS KRAS2 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 MLK3 NRAS PBP PEBP PEBP1 PHB PHB1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 PTK1 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RASK2 RIAM RNF52 SPRK SRC SRC1 TLN TLN1 VCL VWF YWHAB
Signaling by moderate kinase activity BRAF mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein BRCA1-associated protein Beta-arrestin-1 Beta-arrestin-2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase KRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase kinase kinase 11 Phosphatidylethanolamine-binding protein 1 Prohibitin 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 Vinculin von Willebrand factor	O60674 P01111 P01112 P01116 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P35232 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q16584 Q6VAB6 Q7Z569 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9UQM7 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 BRAP CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 KIAA0051 KIAA0902 KIAA0968 KIAA1027 KRAS KRAS2 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 MLK3 NRAS PBP PEBP PEBP1 PHB PHB1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 PTK1 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RASK2 RIAM RNF52 SPRK SRC SRC1 TLN TLN1 VCL VWF YWHAB
Paradoxical activation of RAF signaling by kinase inactive BRAF	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein BRCA1-associated protein Beta-arrestin-1 Beta-arrestin-2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase KRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase kinase kinase 11 Phosphatidylethanolamine-binding protein 1 Prohibitin 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 Vinculin von Willebrand factor	O60674 P01111 P01112 P01116 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P35232 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q16584 Q6VAB6 Q7Z569 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9UQM7 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 BRAP CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 KIAA0051 KIAA0902 KIAA0968 KIAA1027 KRAS KRAS2 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 MLK3 NRAS PBP PEBP PEBP1 PHB PHB1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 PTK1 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RASK2 RIAM RNF52 SPRK SRC SRC1 TLN TLN1 VCL VWF YWHAB
Interleukin-27 signaling	Calnexin Cytokine receptor-like factor 1 Interleukin-27 receptor subunit alpha Interleukin-27 subunit alpha Interleukin-27 subunit beta Interleukin-6 receptor subunit beta Non-receptor tyrosine-protein kinase TYK2 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2	O60674 O75462 P23458 P27824 P29597 P40189 P40763 P42224 Q14213 Q6UWB1 Q8NEV9	APRF CANX CRL1 CRLF1 EBI3 IL27 IL27A IL27B IL27RA IL30 IL6ST JAK1 JAK1A JAK1B JAK2 STAT1 STAT3 TCCR TYK2 WSX1
IL-6-type cytokine receptor ligand interactions	Cardiotrophin-1 Cardiotrophin-like cytokine factor 1 Ciliary neurotrophic factor receptor subunit alpha Ciliary neurotrophic factor Cytokine receptor-like factor 1 Interleukin-11 receptor subunit alpha Interleukin-11 Interleukin-31 receptor subunit alpha Interleukin-31 Interleukin-6 receptor subunit beta Leukemia inhibitory factor receptor Leukemia inhibitory factor Non-receptor tyrosine-protein kinase TYK2 Oncostatin-M-specific receptor subunit beta Oncostatin-M Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2	O60674 O75462 P13725 P15018 P20809 P23458 P26441 P26992 P29597 P40189 P42702 Q14626 Q16619 Q6EBC2 Q8NI17 Q99650 Q9UBD9	BSF3 CLC CLCF1 CNTF CNTFR CRL3 CRLF1 CTF1 GPL HILDA IL11 IL11RA IL31 IL31RA IL6ST JAK1 JAK1A JAK1B JAK2 LIF LIFR NNT1 OSM OSMR OSMRB TYK2
Translesion synthesis by REV1	DNA polymerase zeta catalytic subunit DNA repair protein REV1 Mitotic spindle assembly checkpoint protein MAD2B Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O60673 P0CG47 P0CG48 P12004 P15927 P27694 P35244 P35249 P35250 P35251 P40937 P40938 P62979 P62987 Q9UBZ9 Q9UI95	MAD2B MAD2L2 PCNA POLZ REPA1 REPA2 REPA3 REV1 REV1L REV3 REV3L REV7 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
Translesion synthesis by POLI	DNA polymerase iota DNA polymerase zeta catalytic subunit DNA repair protein REV1 Mitotic spindle assembly checkpoint protein MAD2B Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O60673 P0CG47 P0CG48 P12004 P15927 P27694 P35244 P35249 P35250 P35251 P40937 P40938 P62979 P62987 Q9UBZ9 Q9UI95 Q9UNA4	MAD2B MAD2L2 PCNA POLI POLZ RAD30B REPA1 REPA2 REPA3 REV1 REV1L REV3 REV3L REV7 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
Translesion synthesis by POLK	DNA polymerase kappa DNA polymerase zeta catalytic subunit DNA repair protein REV1 Mitotic spindle assembly checkpoint protein MAD2B Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O60673 P0CG47 P0CG48 P12004 P15927 P27694 P35244 P35249 P35250 P35251 P40937 P40938 P62979 P62987 Q9UBT6 Q9UBZ9 Q9UI95	DINB1 MAD2B MAD2L2 PCNA POLK POLZ REPA1 REPA2 REPA3 REV1 REV1L REV3 REV3L REV7 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2

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