TGF-beta receptor signaling activates SMADs
|
|
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- ALK5
- C14orf141
- CBL
- CBL2
- DPC4
- FKBP1
- FKBP12
- FKBP1A
- FNRB
- FUR
- FURIN
- GP3A
- ITGA8
- ITGAV
- ITGB1
- ITGB3
- ITGB5
- ITGB6
- ITGB8
- LTBP1
- LTBP2
- LTBP3
- LTBP4
- MADH2
- MADH3
- MADH4
- MADR2
- MDF2
- MSK12
- MSK8
- NEDD8
- PACE
- PCSK3
- RNF55
- SKR4
- SMAD2
- SMAD3
- SMAD4
- TGFB
- TGFB1
- TGFB2
- TGFB3
- TGFBR1
- TGFBR2
- TGFBR3
- UBC12
- UBE2M
- VNRA
- VTNR
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TNFR2 non-canonical NF-kB pathway
|
|
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- API1
- API2
- APO3L
- BAFF
- BAFFR
- BIRC2
- BIRC3
- BLYS
- BR3
- C7orf76
- CAP-1
- CD40L
- CD40LG
- CRAF1
- D12S370
- DR3LG
- DSS1
- FN14
- HC2
- HC3
- HC8
- HC9
- HSPC
- HVEML
- IFI5111
- KIAA0072
- KIAA0077
- KIAA0107
- LIGHT
- LMP10
- LMP2
- LMP7
- LMPX
- LMPY
- LTA
- LTB
- LTBR
- MAP3K14
- MB1
- MCB1
- MECL1
- MIHB
- MIHC
- MIP224
- MOV34L
- MSS1
- NIK
- NU
- OPGL
- PFAAP4
- POH1
- PROS26
- PROS27
- PROS30
- PSC2
- PSC3
- PSC5
- PSC8
- PSC9
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMA7L
- PSMA8
- PSMB1
- PSMB10
- PSMB11
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB5i
- PSMB6
- PSMB6i
- PSMB7
- PSMB8
- PSMB9
- PSMC1
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD10
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD4
- PSMD5
- PSMD6
- PSMD7
- PSMD8
- PSMD9
- PSME1
- PSME2
- PSME3
- PSME4
- PSMF1
- RANK
- RANKL
- RING10
- RING12
- RNF48
- RNF49
- SEM1
- SHFDG1
- SHFM1
- SUG1
- SUG2
- TALL1
- TBP1
- TBP7
- TNF
- TNFA
- TNFB
- TNFBR
- TNFC
- TNFCR
- TNFR2
- TNFR3
- TNFRSF11A
- TNFRSF12A
- TNFRSF13C
- TNFRSF1B
- TNFRSF3
- TNFSF1
- TNFSF11
- TNFSF12
- TNFSF13B
- TNFSF14
- TNFSF2
- TNFSF20
- TNFSF3
- TNFSF5
- TRAF2
- TRAF3
- TRAFAMN
- TRANCE
- TRAP
- TRAP2
- TRAP3
- X
- Y
- Y2
- Z
- ZTNF4
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MECP2 regulates transcription of neuronal ligands
|
|
|
- BDNF
- CRH
- DLL1
- HDAC1
- RPD3L1
- SIN3A
- SST
|
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PTK6 Activates STAT3
|
|
|
- APRF
- BKS
- BRK
- CIS3
- PTK6
- SOCS3
- SSI3
- STAP2
- STAT3
|
|
Metallothioneins bind metals
|
|
|
- CES1
- MT1A
- MT1B
- MT1E
- MT1F
- MT1G
- MT1H
- MT1K
- MT1M
- MT1Q
- MT1S
- MT1X
- MT2
- MT2A
- MT3
- MT4
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|
Malate-aspartate shuttle
|
|
|
- AGC1
- ARALAR1
- GC1
- GC2
- GOT1
- GOT2
- KYAT4
- MDH1
- MDH2
- MDHA
- SLC20A4
- SLC25A11
- SLC25A12
- SLC25A13
- SLC25A18
- SLC25A22
|
|
Regulation of TNFR1 signaling
|
|
|
- API1
- API2
- API3
- BIRC2
- BIRC3
- BIRC4
- C20orf18
- CASP8
- CHIP
- CHUK
- CLIP3
- CLIPR59
- CYLD
- CYLD1
- DUBA7
- EBI6
- FADD
- FAM105B
- FIP2
- FIP3
- GLC1E
- GNB2L1
- HIP7
- HYPL
- IAP3
- IKBKB
- IKBKE
- IKBKG
- IKKA
- IKKB
- IKKE
- IKKI
- IMP3
- IMP4
- KIAA0151
- KIAA0722
- KIAA0757
- KIAA0849
- KIAA1532
- MAPKAPK2
- MCH5
- MIB2
- MIHB
- MIHC
- MORT1
- NAK
- NEMO
- NRP
- OPG199
- OPTN
- OTDC1
- OTUD1
- OTUD7B
- OTUD7C
- OTULIN
- PD1
- PSL1
- PSL2
- PUBC1
- RACK1
- RBCK1
- RIP
- RIP1
- RIPK1
- RNF31
- RNF48
- RNF49
- RNF54
- RPS27A
- SFT
- SHARPIN
- SIPL1
- SKD
- SPATA2
- SPI-2
- SPPL2A
- SPPL2B
- STUB1
- T6BP
- TAX1BP1
- TBK1
- TCF16
- TNF
- TNFA
- TNFAIP3
- TNFAR
- TNFR1
- TNFRSF1A
- TNFSF2
- TRADD
- TRAF1
- TRAF2
- TRAP3
- UBA52
- UBA80
- UBB
- UBC
- UBC4
- UBC5A
- UBC5B
- UBC5C
- UBCE7
- UBCE7IP3
- UBCEP1
- UBCEP2
- UBCH4
- UBCH5
- UBCH5A
- UBCH5B
- UBCH5C
- UBCH7
- UBE2D1
- UBE2D2
- UBE2D3
- UBE2L3
- UBP41
- UL36
- ULK1
- UNP
- UNPH
- USP2
- USP21
- USP23
- USP4
- XAP3
- XAP4
- XIAP
- ZA20D1
- ZIBRA
- ZZANK1
|
|
Regulation of KIT signaling
|
|
|
- APS
- CBL
- CBL2
- CIS4
- FYN
- HCP
- JTK8
- KIT
- LCK
- LNK
- LYN
- PKCA
- PRKACA
- PRKCA
- PTP1C
- PTPN6
- RNF55
- SCFR
- SH2B2
- SH2B3
- SOCS1
- SOCS4
- SOCS6
- SOS1
- SSI1
- TIP3
- YES
- YES1
|
|
Phenylalanine metabolism
|
|
|
- ALP
- ASRGL1
- CCBL1
- CRASH
- DCOH
- DHPR
- FIG1
- IL4I1
- KYAT1
- PAH
- PCBD
- PCBD1
- QDPR
- SDR33C1
|
|
Opsins
|
|
|
- BCP
- ECPN
- GCP
- GPR136
- MOP
- OPN1LW
- OPN1MW
- OPN1SW
- OPN2
- OPN3
- OPN4
- OPN5
- PGR12
- RCP
- RGR
- RHO
- RRH
- TMEM13
|
|
Defective MAN1B1 causes MRT15
|
|
|
|
|
SHC1 events in ERBB4 signaling
|
|
|
- BTC
- DTR
- DTS
- EREG
- GGF
- HBEGF
- HEGFL
- HGL
- HRAS
- HRAS1
- HRGA
- NDF
- NRAS
- NRG1
- NRG2
- NRG3
- NRG4
- NTAK
- SHC
- SHC1
- SHCA
- SMDF
- SOS1
|
|
Gain-of-function MRAS complexes activate RAF signaling
|
|
|
- ARAF
- ARAF1
- BRAF
- BRAF1
- KIAA0862
- MRAS
- PKS
- PKS2
- PPP1CB
- PPP1CC
- RAF
- RAF1
- RAFB1
- RRAS3
- SHOC2
- YWHAB
|
|
Synthesis of PIPs at the Golgi membrane
|
|
|
- ARF1
- ARF3
- FIG4
- INPP5E
- KIAA0274
- KIAA0851
- KIAA0981
- OCRL
- OCRL1
- PI4K2A
- PI4K2B
- PI4KA
- PI4KB
- PIK3C2A
- PIK3C2G
- PIK3C3
- PIK3R4
- PIK4
- PIK4CA
- PIK4CB
- PIKFYVE
- PIP5K3
- SAC1
- SAC3
- SACM1L
- TAX1BP2
- TPIP
- TPTE
- TPTE2
- TRX
- VAC14
- VPS15
- VPS34
|
|
Ion homeostasis
|
|
|
- ABCC9
- AHCYL1
- ASPH
- ATP1A1
- ATP1A2
- ATP1A3
- ATP1A4
- ATP1AL2
- ATP1B
- ATP1B1
- ATP1B2
- ATP1B3
- ATP1C
- ATP1G1
- ATP2A1
- ATP2A2
- ATP2A3
- ATP2B
- ATP2B1
- ATP2B2
- ATP2B3
- ATP2B4
- BAH
- C7orf19
- CALM
- CALM1
- CAM
- CAM1
- CAM2
- CAMK
- CAMK-II
- CAMK2
- CAMK2A
- CAMK2B
- CAMK2D
- CAMK2G
- CAMKA
- CAMKB
- CAMKD
- CAMKG
- CBCIP2
- CLIC2
- CNC
- CRACM1
- DCAL
- DM1PK
- DMPK
- FKBP12.6
- FKBP1B
- FKBP1L
- FKBP9
- FXYD1
- FXYD2
- FXYD3
- FXYD4
- FXYD6
- FXYD7
- GOK
- HBRR
- INSP3R1
- IRBIT
- ITPR1
- ITPR2
- ITPR3
- KCNJ11
- KIAA0778
- KIAA0968
- KIAA1087
- MAT8
- MDPK
- MXRA1
- NCX1
- NCX2
- NCX3
- NOS1
- ORAI1
- ORAI2
- OTK4
- PKACA
- PLB
- PLM
- PLML
- PLN
- PMCA1
- PMCA2
- PRKACA
- RYDR
- RYR1
- RYR2
- RYR3
- SLC8A1
- SLC8A2
- SLC8A3
- SLN
- SRI
- STIM1
- SUR2
- TMEM142A
- TMEM142B
- TNNC1
- TNNI3
- TRDN
- TRP1
- TRPC1
- XPVKONA
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|
Platelet Adhesion to exposed collagen
|
|
|
- ADAMTS13
- C9orf8
- CD49B
- F8VWF
- FCER1G
- FNRB
- FYN
- GP1BA
- GP1BB
- GP5
- GP6
- GP9
- ITGA1
- ITGA10
- ITGA2
- ITGB1
- JTK8
- LYN
- MDF2
- MSK12
- VWF
|
|
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
|
|
|
- 1C7
- AICL
- AIRM1
- AMICA1
- B2M
- B7H6
- BY55
- C12orf53
- C3
- C6orf76
- CAR
- CD11A
- CD158A
- CD158B1
- CD158B2
- CD158D
- CD158E
- CD158H
- CD158J
- CD158K
- CD160
- CD16A
- CD18
- CD19
- CD1A
- CD1B
- CD1C
- CD1D
- CD200
- CD200R
- CD200R1
- CD22
- CD225
- CD226
- CD300A
- CD300B
- CD300C
- CD300D
- CD300E
- CD300F
- CD300LB
- CD300LD
- CD300LE
- CD300LF
- CD300LG
- CD305
- CD306
- CD32
- CD33
- CD33L
- CD33L1
- CD33L2
- CD3D
- CD3E
- CD3G
- CD40L
- CD40LG
- CD49D
- CD81
- CD8A
- CD8B
- CD8B1
- CD94
- CD96
- CD99
- CDH1
- CDHE
- CLAX
- CLEC15A
- CLEC2B
- CLEC2D
- CLEC4G
- CLEC5B
- CLEC5C
- CLECSF2
- CLM1
- CLM2
- CLM7
- CLM9
- CLP1
- CMRF35
- CMRF35A
- CMRF35A1
- CMRF35A2
- CMRF35A4
- CMRF35A5
- CMRF35H
- COLEC12
- CPAMD1
- CRTAM
- CRTR2
- CS1
- CXADR
- D12S2489E
- DAP10
- DAP12
- DNAM1
- DSHP
- EAT2
- FCG1
- FCG2
- FCG3
- FCGR1
- FCGR1A
- FCGR2B
- FCGR3
- FCGR3A
- FDFACT
- FNRB
- GLYCAM1
- HA
- HCST
- HLA-5.4
- HLA-6.0
- HLA-6.2
- HLA-A
- HLA-B
- HLA-C
- HLA-E
- HLA-F
- HLA-G
- HLA-H
- HLAA
- HLAB
- HLAC
- HLAE
- HLAF
- HLAG
- HLAH
- HN
- HVEB
- ICAM1
- ICAM2
- ICAM3
- ICAM4
- ICAM5
- IFI17
- IFITM1
- IFNRG1
- IGFR1
- IGFR2
- IGFR3
- IGHV
- IGHV1-2
- IGHV1-46
- IGHV1-69
- IGHV2-5
- IGHV2-70
- IGHV3-11
- IGHV3-13
- IGHV3-23
- IGHV3-30
- IGHV3-33
- IGHV3-48
- IGHV3-53
- IGHV3-7
- IGHV3-9
- IGHV4-34
- IGHV4-39
- IGHV4-59
- IGHV7-81
- IGKC
- IGKV1-12
- IGKV1-16
- IGKV1-17
- IGKV1-33
- IGKV1-39
- IGKV1-5
- IGKV1D-12
- IGKV1D-16
- IGKV1D-33
- IGKV1D-39
- IGKV2-28
- IGKV2-29
- IGKV2-30
- IGKV2D-28
- IGKV2D-30
- IGKV2D-40
- IGKV3-11
- IGKV3-15
- IGKV3-20
- IGKV3D-20
- IGKV4-1
- IGKV5-2
- IGLC1
- IGLC2
- IGLC3
- IGLC6
- IGLC7
- IGLV
- IGLV1-40
- IGLV1-44
- IGLV1-47
- IGLV1-51
- IGLV2-11
- IGLV2-14
- IGLV2-23
- IGLV2-8
- IGLV3-1
- IGLV3-19
- IGLV3-21
- IGLV3-25
- IGLV3-27
- IGLV6-57
- IGLV7-43
- IGSF12
- IGSF13
- IGSF16
- ILT1
- ILT11
- ILT2
- ILT3
- ILT4
- ILT5
- ILT6
- ILT7
- ILT8
- IREM1
- IREM2
- IREM3
- ITGA4
- ITGAL
- ITGB1
- ITGB2
- ITGB7
- JAML
- KALI
- KAP10
- KARAP
- KIR103AS
- KIR2DL1
- KIR2DL2
- KIR2DL3
- KIR2DL4
- KIR2DS1
- KIR2DS2
- KIR3DL1
- KIR3DL2
- KIRCL23
- KLRB1
- KLRC1
- KLRD1
- KLRF1
- KLRG1
- KLRK1
- LAIR1
- LAIR2
- LETAL
- LILRA1
- LILRA2
- LILRA3
- LILRA4
- LILRA5
- LILRA6
- LILRB1
- LILRB2
- LILRB3
- LILRB4
- LILRB5
- LILRB7
- LIR1
- LIR2
- LIR3
- LIR4
- LIR5
- LIR6
- LIR7
- LIR8
- LIR9
- LLT1
- LMIR5
- LNHR
- LW
- LY117
- LY94
- LY95
- LYAM1
- MAFA
- MAFAL
- MAL
- MDF2
- MFI7
- MIC2
- MIC2X
- MIC2Y
- MICA
- MICB
- MIR10
- MIR7
- ML
- MOX1
- MOX2
- MOX2R
- MSK12
- N2DL1
- N2DL3
- N2DL4
- NCR1
- NCR2
- NCR3
- NCR3LG1
- NECTIN2
- NKAT1
- NKAT2
- NKAT3
- NKAT4
- NKAT5
- NKAT6
- NKB1
- NKG2A
- NKG2D
- NKIR
- NKRP1A
- NPDC1
- NSR2
- OBBP1
- OBBP2
- OCIL
- OSCAR
- OX2R
- PANP
- PERB11.1
- PERB11.2
- PIANP
- PIK3AP
- PILRA
- PILRB
- PRR2
- PVR
- PVRL2
- PVS
- RAET1E
- RAET1I
- RAET1N
- SAF2
- SAP
- SCARA4
- SELL
- SH2D1A
- SH2D1B
- SIGLEC1
- SIGLEC10
- SIGLEC11
- SIGLEC12
- SIGLEC2
- SIGLEC3
- SIGLEC5
- SIGLEC6
- SIGLEC7
- SIGLEC8
- SIGLEC9
- SIGLECL1
- SLAMF6
- SLAMF7
- SLG
- SLG2
- SN
- SRCL
- T3D
- T3E
- T3G
- TAPA1
- TCRA
- TCRBV12S3
- TCRBV8S1
- TLCN
- TLN
- TLT1
- TLT2
- TLT4
- TNFSF5
- TRAC
- TRAP
- TRAV19
- TRAV29DV5
- TRAV8-4
- TRBC1
- TRBV12-3
- TRBV7-9
- TREM1
- TREM2
- TREM4
- TREM5
- TREML1
- TREML2
- TREML4
- TSPAN28
- TYROBP
- UL83
- ULBP1
- ULBP3
- ULBP4
- UVO
- V1-11
- V1-13
- V1-16
- V1-20
- V1-3
- V1-5
- V1-7
- V1-9
- V2-11
- V2-15
- V2-17
- V2-19
- V2-8
- V3-2
- V3-3
- V3-4
- V4-1
- V4-2
- V4-6
- V5-1
- V5-4
- V5-6
- VCAM1
- cd21
|
|
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
|
|
|
- ACTL6
- ACTL6A
- ACTL6B
- AML1
- ARID1A
- ARID1B
- ARID2
- AUTS2
- BAF155
- BAF170
- BAF180
- BAF190A
- BAF190B
- BAF200
- BAF250
- BAF250A
- BAF250B
- BAF47
- BAF53
- BAF53A
- BAF53B
- BAF57
- BAF60A
- BAF60B
- BAF60C
- BAP1
- BMI1
- BRG1
- BRM
- C1orf4
- CBFA2
- CBFB
- CBX2
- CBX4
- CBX6
- CBX8
- CK2A1
- CK2A2
- CK2N
- CSNK2A1
- CSNK2A2
- CSNK2B
- DAN15
- DEDAF
- DING
- EDR1
- EDR2
- EDR3
- EP300
- G5A
- HIPI3
- HIPK2
- INI1
- INO80K
- KIAA0442
- KIAA1235
- KIAA1557
- OSA1
- OSA2
- P300
- PB1
- PBRM1
- PC3
- PCGF4
- PCGF5
- PH1
- PH2
- PH3
- PHC1
- PHC2
- PHC3
- RC1
- RING1
- RING1A
- RING1B
- RNF1
- RNF159
- RNF2
- RNF51
- RUNX1
- RYBP
- SMARCA2
- SMARCA4
- SMARCB1
- SMARCC1
- SMARCC2
- SMARCD1
- SMARCD2
- SMARCD3
- SMARCE1
- SMARCF1
- SNF2A
- SNF2B
- SNF2L2
- SNF2L4
- SNF5L1
- YAF2
- YEAF1
|
|
Activation and oligomerization of BAK protein
|
|
|
|
|
Regulation of TP53 Activity through Association with Co-factors
|
|
|
- AKT1
- AKT2
- AKT3
- ASPP1
- ASPP2
- BANP
- BBP
- BEND1
- BRN3A
- BRN3B
- C20orf104
- GLEA2
- HCA58
- HZF
- IASPP
- KET
- KIAA0771
- NKIP1
- NZF
- P53
- P63
- P73
- P73H
- P73L
- PHF20
- PKB
- PKBG
- POU4F1
- POU4F2
- PPP1R13B
- PPP1R13BL
- PPP1R13L
- RAC
- RAI
- RDC1
- RZF
- SMAR1
- TP53
- TP53BP2
- TP63
- TP73
- TP73L
- TZP
- ZNF385
- ZNF385A
|
|
cGMP effects
|
- Calcium-activated potassium channel subunit alpha-1
- Calcium-activated potassium channel subunit beta-1
- Calcium-activated potassium channel subunit beta-2
- Calcium-activated potassium channel subunit beta-3
- Calcium-activated potassium channel subunit beta-4
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
- Inositol 1,4,5-triphosphate receptor associated 1
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
- cGMP-dependent 3',5'-cyclic phosphodiesterase
- cGMP-dependent protein kinase 2
- cGMP-specific 3',5'-cyclic phosphodiesterase
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- INSP3R1
- IRAG
- IRAG1
- ITPR1
- JAW1L
- KCNMA
- KCNMA1
- KCNMB1
- KCNMB2
- KCNMB3
- KCNMB4
- KCNMBL
- MRVI1
- PDE10A
- PDE11A
- PDE1A
- PDE1B
- PDE2A
- PDE5
- PDE5A
- PDE9A
- PDES1B
- PRKG2
- PRKGR2
- SLO
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Intestinal hexose absorption
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- GLUT2
- GLUT5
- NAGT
- RSC1A1
- SGLT1
- SLC2A2
- SLC2A5
- SLC5A1
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Prevention of phagosomal-lysosomal fusion
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- CORO1
- CORO1A
- HGS
- HRS
- RAB5
- RAB5A
- RAB7
- RAB7A
- RPS27A
- Rv1410c
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- VPS33B
- cfp7
- esxG
- esxH
- lpd
- lpdC
- lpp-27
- lprG
- mptpA
- ndk
- ndkA
- ptpA
- sapM
- secA2
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SUMO is conjugated to E1 (UBA2:SAE1)
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- AOS1
- SAE1
- SAE2
- SMT3A
- SMT3B
- SMT3C
- SMT3H1
- SMT3H2
- SMT3H3
- SUA1
- SUMO1
- SUMO2
- SUMO3
- UBA2
- UBL1
- UBLE1A
- UBLE1B
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Defective MAOA causes BRUNS
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