Synthesis of PIPs at the early endosome membrane
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- CG2
- FIG4
- INPP4A
- INPP4B
- INPP5F
- KIAA0274
- KIAA0647
- KIAA0966
- KIAA0981
- KIAA1073
- KIAA1682
- MTM1
- MTMR10
- MTMR12
- MTMR2
- MTMR4
- PI4K2A
- PI4K2B
- PIK3C2A
- PIK3C3
- PIK3R4
- PIKFYVE
- PIP3AP
- PIP5K3
- SAC2
- SAC3
- TAX1BP2
- TRX
- VAC14
- VPS15
- VPS34
- ZFYVE11
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Synthesis of PIPs at the late endosome membrane
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- C8orf9
- CG2
- FIG4
- KIAA0274
- KIAA0647
- KIAA0981
- KIAA1073
- MTM1
- MTMR2
- MTMR4
- MTMR7
- MTMR8
- MTMR9
- PIK3C2A
- PIK3C3
- PIK3R4
- PIKFYVE
- PIP5K3
- SAC3
- TAX1BP2
- TRX
- VAC14
- VPS15
- VPS34
- ZFYVE11
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Synthesis of PIPs at the plasma membrane
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- ADP-ribosylation factor 1
- Cytoplasmic tyrosine-protein kinase BMX
- Inositol polyphosphate 4-phosphatase type II
- Inositol polyphosphate 5-phosphatase K
- Inositol polyphosphate 5-phosphatase OCRL
- Inositol polyphosphate-4-phosphatase type I A
- Myotubularin-related protein 13
- Myotubularin-related protein 14
- Myotubularin-related protein 1
- Myotubularin-related protein 2
- Myotubularin-related protein 3
- Myotubularin-related protein 6
- Myotubularin-related protein 8
- Myotubularin-related protein 9
- Myotubularin
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
- Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Phosphatidylinositol 3-kinase regulatory subunit gamma
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
- Phosphatidylinositol 4-kinase type 2-alpha
- Phosphatidylinositol 4-kinase type 2-beta
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
- Phosphoinositide 3-kinase regulatory subunit 5
- Phosphoinositide 3-kinase regulatory subunit 6
- Pleckstrin homology domain-containing family A member 1
- Pleckstrin homology domain-containing family A member 2
- Pleckstrin homology domain-containing family A member 3
- Pleckstrin homology domain-containing family A member 4
- Pleckstrin homology domain-containing family A member 5
- Pleckstrin homology domain-containing family A member 6
- Pleckstrin homology domain-containing family A member 8
- RUN and FYVE domain-containing protein 1
- Ras-related protein Rab-14
- Ras-related protein Rab-4A
- Ras-related protein Rab-5A
- Synaptojanin-1
- Synaptojanin-2
- Tyrosine-protein phosphatase non-receptor type 13
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- ARF1
- BMX
- C17orf38
- C3orf29
- C8orf9
- CG2
- CMT4B2
- FAPP1
- FAPP2
- GRB1
- INPP4A
- INPP4B
- INPP5D
- INPP5J
- INPP5K
- INPPL1
- KIAA0348
- KIAA0371
- KIAA0589
- KIAA0910
- KIAA0969
- KIAA1073
- KIAA1686
- KIAA1766
- MMAC1
- MTM1
- MTMR1
- MTMR13
- MTMR14
- MTMR2
- MTMR3
- MTMR6
- MTMR8
- MTMR9
- OCRL
- OCRL1
- PEPP1
- PEPP2
- PEPP3
- PI4K2A
- PI4K2B
- PI5P4KA
- PIB5PA
- PIK3C1
- PIK3C2A
- PIK3C2B
- PIK3C2G
- PIK3CA
- PIK3CB
- PIK3CD
- PIK3CG
- PIK3R1
- PIK3R2
- PIK3R3
- PIK3R5
- PIK3R6
- PIP4K2A
- PIP4K2B
- PIP4K2C
- PIP5K1A
- PIP5K1B
- PIP5K1C
- PIP5K2
- PIP5K2A
- PIP5K2B
- PIP5K2C
- PIPP
- PLEKHA1
- PLEKHA2
- PLEKHA3
- PLEKHA4
- PLEKHA5
- PLEKHA6
- PLEKHA8
- PNP1
- PPS
- PTEN
- PTP1E
- PTPL1
- PTPN13
- RAB14
- RAB4
- RAB4A
- RAB5
- RAB5A
- RABIP4
- RUFY1
- SBF2
- SHIP
- SHIP1
- SHIP2
- SKIP
- STM7
- SYNJ1
- SYNJ2
- TAPP1
- TAPP2
- TEP1
- ZFYVE10
- ZFYVE12
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Synthesis of PIPs in the nucleus
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- C14orf9
- PI5P4KA
- PIP4K2A
- PIP4K2B
- PIP4K2C
- PIP4P1
- PIP5K2
- PIP5K2A
- PIP5K2B
- PIP5K2C
- TMEM55B
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Synthesis of PS
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- KIAA0024
- PSS2
- PSSA
- PTDSS1
- PTDSS2
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Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
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- AKR1C3
- C1orf93
- C9orf15
- CBR
- CBR1
- COX1
- COX2
- CRN
- CYP12
- CYP5
- CYP5A1
- CYP8
- CYP8A1
- CYP8B1
- DDH1
- FAM213B
- GSTS
- HPGD
- HPGDS
- HSD17B5
- KIAA0119
- MGST1L1
- MPGES1
- P23
- PDS
- PGDH1
- PGDS
- PGES
- PGES2
- PGFS
- PIG12
- PRXL2B
- PTGDS
- PTGDS2
- PTGES
- PTGES2
- PTGES3
- PTGIS
- PTGR2
- PTGS1
- PTGS2
- SDR21C1
- SDR36C1
- TBXAS1
- TEBP
- TXAS
- ZADH1
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Synthesis of UDP-N-acetyl-glucosamine
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- AGM1
- AMDHD2
- GFAT
- GFPT
- GFPT1
- GFPT2
- GNA1
- GNPNAT1
- NAGK
- PGM3
- RENBP
- SPAG2
- UAP1
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Synthesis of active ubiquitin: roles of E1 and E2 enzymes
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- A1S9T
- CDC34
- CDC34B
- DFFRX
- E2EPF
- FAM
- FAM105B
- HAUSP
- HIP2
- ISOT
- LIG
- MOP4
- OTULIN
- PUBC1
- RAD6A
- RAD6B
- RPS27A
- SFT
- UBA1
- UBA52
- UBA6
- UBA80
- UBB
- UBC
- UBC16
- UBC3B
- UBC4
- UBC5A
- UBC5B
- UBC7
- UBCE4
- UBCE7
- UBCEP1
- UBCEP2
- UBCH1
- UBCH10
- UBCH3
- UBCH4
- UBCH5
- UBCH5A
- UBCH5B
- UBCH6
- UBCH7
- UBCH9
- UBE1
- UBE1L2
- UBE2A
- UBE2B
- UBE2C
- UBE2D1
- UBE2D2
- UBE2E1
- UBE2E3
- UBE2G
- UBE2G1
- UBE2G2
- UBE2H
- UBE2K
- UBE2L3
- UBE2Q2
- UBE2R1
- UBE2R2
- UBE2S
- UBE2T
- UBE2W
- UBE2Z
- UCHL3
- USP5
- USP7
- USP9
- USP9X
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Synthesis of bile acids and bile salts
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- BAR
- BHLHE74
- BHLHE75
- CH25H
- CYP7
- CYP7A1
- CYP7B1
- FXR
- HRR1
- KIAA0704
- KIAA0772
- NCOA1
- NCOA2
- NR1H4
- NR2B1
- ORP1
- ORP2
- ORP3
- ORP6
- ORP7
- ORP9
- OSBP
- OSBP1
- OSBP3
- OSBP4
- OSBP8
- OSBPL1
- OSBPL1A
- OSBPL1B
- OSBPL2
- OSBPL3
- OSBPL6
- OSBPL7
- OSBPL9
- RIP14
- RXRA
- SRC1
- SRC2
- TIF2
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Synthesis of bile acids and bile salts via 24-hydroxycholesterol
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- ACSB
- ACSVL1
- ACSVL6
- AKR1C1
- AKR1C2
- AKR1C3
- AKR1C4
- AKR1D1
- AMACR
- CHDR
- CYP12
- CYP27
- CYP27A1
- CYP39A1
- CYP46
- CYP46A1
- CYP8
- CYP8A1
- CYP8B1
- DDH
- DDH1
- DDH2
- FACVL1
- FACVL3
- FATP2
- FATP5
- HSD17B5
- HSD3B7
- KIAA0119
- PGFS
- PTGIS
- SLC27A2
- SLC27A5
- SRD5B1
- VLACS
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Synthesis of bile acids and bile salts via 27-hydroxycholesterol
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- AKR1C1
- AKR1C2
- AKR1C3
- AKR1C4
- AKR1D1
- BAR
- BHLHE74
- BHLHE75
- CHDR
- CYP12
- CYP27
- CYP27A1
- CYP7
- CYP7A1
- CYP7B1
- CYP8
- CYP8A1
- CYP8B1
- DDH
- DDH1
- DDH2
- FXR
- HRR1
- HSD17B5
- HSD3B7
- KIAA0119
- NCOA1
- NCOA2
- NR1H4
- NR2B1
- PGFS
- PTGIS
- RIP14
- RXRA
- SRC1
- SRC2
- SRD5B1
- TIF2
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Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
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- ABCB11
- ACOT8
- ACOX2
- ACSB
- ACSVL1
- ACSVL6
- ACTEIII
- AKR1C1
- AKR1C2
- AKR1C3
- AKR1C4
- AKR1D1
- AMACR
- BAAT
- BAR
- BHLHE74
- BHLHE75
- BSEP
- CHDR
- CYP12
- CYP27
- CYP27A1
- CYP7
- CYP7A1
- CYP7B1
- CYP8
- CYP8A1
- CYP8B1
- DDH
- DDH1
- DDH2
- EDH17B4
- FACVL1
- FACVL3
- FATP2
- FATP5
- FXR
- HRR1
- HSD17B4
- HSD17B5
- HSD3B7
- KIAA0119
- NCOA1
- NCOA2
- NR1H4
- NR2B1
- PGFS
- PTE1
- PTGIS
- RIP14
- RXRA
- SDR8C1
- SLC27A2
- SLC27A5
- SRC1
- SRC2
- SRD5B1
- TIF2
- VLACS
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Synthesis of diphthamide-EEF2
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- ATPBD4
- C9orf112
- DESR1
- DNAJC24
- DPH1
- DPH2
- DPH2L
- DPH2L1
- DPH2L2
- DPH3
- DPH4
- DPH5
- DPH6
- DPH7
- EEF2
- EF2
- OVCA1
- WDR85
- ZCSL2
- ZCSL3
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Synthesis of dolichyl-phosphate mannose
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Synthesis of dolichyl-phosphate-glucose
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Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
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- CYP1A1
- CYP1A2
- CYP1B1
- CYP2C10
- CYP2C19
- CYP2C8
- CYP2C9
- CYP2J2
- EPHX2
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Synthesis of glycosylphosphatidylinositol (GPI)
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- DCRC
- DPM2
- DSCR5
- DSCRC
- GPI2
- GPI7
- MCD4
- PIGA
- PIGB
- PIGC
- PIGF
- PIGG
- PIGH
- PIGL
- PIGM
- PIGN
- PIGO
- PIGP
- PIGV
- PIGW
- PIGX
- PIGY
- PIGZ
- SMP3
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Synthesis of pyrophosphates in the cytosol
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- APS1
- APS2
- C9orf12
- DIPP
- DIPP1
- DIPP2
- DIPP3A
- DIPP3B
- HISPPD1
- HISPPD2A
- IHPK1
- IHPK3
- IP6K
- IP6K1
- IP6K3
- IPPK
- IPS1
- ITPK1
- KIAA0263
- KIAA0377
- KIAA0433
- KIAA0487
- NUDT10
- NUDT11
- NUDT3
- NUDT4
- PPIP5K1
- PPIP5K2
- VIP1
- VIP2
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Synthesis of very long-chain fatty acyl-CoAs
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- ACS2
- ACS3
- ACS4
- ACS5
- ACSBG1
- ACSBG2
- ACSF3
- ACSL1
- ACSL3
- ACSL4
- ACSL5
- ACSL6
- ACSVL3
- BGM
- BGR
- BIND1
- CIG30
- EDH17B3
- ELG3
- ELOVL1
- ELOVL2
- ELOVL3
- ELOVL4
- ELOVL5
- ELOVL6
- ELOVL7
- FACE
- FACL1
- FACL2
- FACL3
- FACL4
- FACL5
- FACL6
- FATP3
- GPSN2
- HACD1
- HACD2
- HACD3
- HACD4
- HSD17B12
- HSD17B3
- KIAA0631
- KIAA0837
- LACS
- LACS1
- LACS2
- LACS3
- LACS4
- LACS5
- LCE
- LPD
- PTPLA
- PTPLAD1
- PTPLAD2
- PTPLB
- SC2
- SDR12C1
- SDR12C2
- SLC27A3
- SRD5A2L2
- SSC1
- SSC2
- TECR
- TECRL
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Synthesis of wybutosine at G37 of tRNA(Phe)
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- C1orf171
- C2orf60
- KIAA0547
- KIAA1393
- LCMT2
- RSAFD1
- TRM12
- TRM5
- TRMT12
- TRMT5
- TYW1
- TYW2
- TYW3
- TYW4
- TYW5
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Synthesis, secretion, and deacylation of Ghrelin
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- ACHE
- BCHE
- CHE1
- CRF2R
- CRH2R
- CRHR2
- EZF
- GCG
- GH1
- GKLF
- GOAT
- IBP1
- IGF1
- INS
- KIAA0102
- KLF4
- LEP
- MBOAT4
- NEC1
- OACT4
- OB
- OBS
- PAFAH
- PCSK1
- PLA2G7
- SEC11A
- SEC11C
- SEC11L1
- SEC11L3
- SPC12
- SPC18
- SPC21
- SPC22
- SPC25
- SPCS1
- SPCS2
- SPCS3
- SPCS4A
- SPCS4C
- UCN
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Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
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- ADCP2
- AN2
- CD26
- CDX2
- CDX3
- CTNNB
- CTNNB1
- DPP4
- FFAR1
- FFAR4
- GCG
- GNAT3
- GNB1
- GNB3
- GNG13
- GPR119
- GPR120
- GPR129
- GPR40
- GRP
- KIAA0102
- LEP
- NEC1
- O3FAR1
- OB
- OBS
- PAX6
- PCSK1
- PGR4
- SEC11A
- SEC11C
- SEC11L1
- SEC11L3
- SPC12
- SPC18
- SPC21
- SPC22
- SPC25
- SPCS1
- SPCS2
- SPCS3
- SPCS4A
- SPCS4C
- TCF4
- TCF7L2
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Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
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- ADCP2
- AN2
- CD26
- DPP4
- FFAR1
- GATA4
- GIP
- GPR119
- GPR40
- ISL1
- KIAA0102
- NEC1
- PAX6
- PCSK1
- SEC11A
- SEC11C
- SEC11L1
- SEC11L3
- SPC12
- SPC18
- SPC21
- SPC22
- SPC25
- SPCS1
- SPCS2
- SPCS3
- SPCS4A
- SPCS4C
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TAK1-dependent IKK and NF-kappa-B activation
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- A4
- AD1
- AGER
- ALPK1
- APP
- BLU
- CARD15
- CARD4
- CARDIAK
- CHUK
- CROC1
- FIP3
- HMG1
- HMGB1
- IKBA
- IKBB
- IKBKB
- IKBKG
- IKKA
- IKKB
- IRAK
- IRAK1
- IRAK2
- ISG43
- KBRAS1
- KBRAS2
- KIAA0733
- KIAA1527
- LAK
- LYT10
- MAD3
- MAP3K7
- MAP3K7IP1
- MAP3K7IP2
- MAP3K7IP3
- N
- NEMO
- NFKB1
- NFKB2
- NFKB3
- NFKBI
- NFKBIA
- NFKBIB
- NKIRAS1
- NKIRAS2
- NOD1
- NOD2
- RAGE
- RELA
- RICK
- RIP2
- RIPK2
- RNF85
- RPS27A
- S100A12
- S100B
- SAA1
- T2BP
- TAB1
- TAB2
- TAB3
- TAK1
- TCF16
- TIFA
- TRAF6
- TRIP9
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- UBE2N
- UBE2V
- UBE2V1
- UEV1
- USP18
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TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P
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