FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
|
|
|
- AIK
- AIRK1
- ARK1
- AURA
- AURKA
- AYK1
- BTAK
- C7orf76
- CUL1
- DSS1
- EMC19
- FBL18
- FBL6
- FBL7
- FBXL18
- FBXL7
- HC2
- HC3
- HC8
- HC9
- HSPC
- IAK1
- IFI5111
- KIAA0072
- KIAA0077
- KIAA0107
- KIAA0840
- LMP10
- LMP2
- LMP7
- LMPX
- LMPY
- MB1
- MCB1
- MECL1
- MIP224
- MOV34L
- MSS1
- NU
- OCP2
- PFAAP4
- POH1
- PROS26
- PROS27
- PROS30
- PSC2
- PSC3
- PSC5
- PSC8
- PSC9
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMA7L
- PSMA8
- PSMB1
- PSMB10
- PSMB11
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB5i
- PSMB6
- PSMB6i
- PSMB7
- PSMB8
- PSMB9
- PSMC1
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD10
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD4
- PSMD5
- PSMD6
- PSMD7
- PSMD8
- PSMD9
- PSME1
- PSME2
- PSME3
- PSME4
- PSMF1
- RBX1
- RING10
- RING12
- RNF75
- ROC1
- RPS27A
- SEM1
- SHFDG1
- SHFM1
- SKP1
- SKP1A
- STK15
- STK6
- SUG1
- SUG2
- TBP1
- TBP7
- TCEB1L
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- X
- Y
- Y2
- Z
|
|
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3
|
|
|
|
|
STAT5 Activation
|
|
|
- CD135
- FLK2
- FLT3
- FLT3LG
- GAB2
- KIAA0571
- PTP2C
- PTPN11
- SHPTP2
- STAT5
- STAT5A
- STAT5B
- STK1
|
|
Complex I biogenesis
|
- Acyl carrier protein, mitochondrial
- Arginine-hydroxylase NDUFAF5, mitochondrial
- Complex I assembly factor ACAD9, mitochondrial
- Complex I assembly factor TIMMDC1, mitochondrial
- Complex I assembly factor TMEM126B, mitochondrial
- Complex I intermediate-associated protein 30, mitochondrial
- Cytochrome c oxidase assembly factor 1 homolog
- Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
- Iron-sulfur cluster transfer protein NUBPL
- NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
- NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
- NADH dehydrogenase [ubiquinone] 1 subunit C2
- NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
- NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
- NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 2
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase chain 4
- NADH-ubiquinone oxidoreductase chain 5
- NADH-ubiquinone oxidoreductase chain 6
- Protein arginine methyltransferase NDUFAF7, mitochondrial
- Transmembrane protein 186
|
|
- ACAD9
- C14orf127
- C16orf51
- C20orf7
- C2orf56
- C3orf1
- C3orf60
- C6orf66
- C7orf44
- C8orf38
- CIA30
- COA1
- DAP13
- ECSIT
- GRIM19
- HRPAP20
- LYRM3
- LYRM6
- MITRAC15
- MT-ND1
- MT-ND2
- MT-ND3
- MT-ND4
- MT-ND5
- MT-ND6
- MTND1
- MTND2
- MTND3
- MTND4
- MTND5
- MTND6
- NADH1
- NADH2
- NADH3
- NADH4
- NADH5
- NADH6
- NADHB14
- ND1
- ND2
- ND3
- ND4
- ND5
- ND6
- NDUFA1
- NDUFA10
- NDUFA11
- NDUFA12
- NDUFA12L
- NDUFA13
- NDUFA2
- NDUFA3
- NDUFA5
- NDUFA6
- NDUFA7
- NDUFA8
- NDUFA9
- NDUFAB1
- NDUFAF1
- NDUFAF2
- NDUFAF3
- NDUFAF4
- NDUFAF5
- NDUFAF6
- NDUFAF7
- NDUFB1
- NDUFB10
- NDUFB11
- NDUFB2
- NDUFB3
- NDUFB4
- NDUFB5
- NDUFB6
- NDUFB7
- NDUFB8
- NDUFB9
- NDUFC1
- NDUFC2
- NDUFS1
- NDUFS2
- NDUFS2L
- NDUFS3
- NDUFS4
- NDUFS5
- NDUFS6
- NDUFS7
- NDUFS8
- NDUFV1
- NDUFV2
- NDUFV3
- NUBPL
- TIMMDC1
- TMEM126B
- TMEM186
- UQOR1
- UQOR22
|
|
Pregnenolone biosynthesis
|
|
|
- ADX
- ADXR
- AKR1B1
- ALDR1
- ALR2
- BZRAP1
- BZRP
- CAB1
- CYP11A
- CYP11A1
- FDX1
- FDX1L
- FDX2
- FDXR
- KIAA0612
- MBR
- MENTHO
- MLN64
- RBP1
- RIMBP1
- STAR
- STARD1
- STARD3
- STARD3NL
- STARD4
- STARD6
- TSPO
- TSPOAP1
|
|
Defective DPM3 causes CDG-1o
|
|
|
|
|
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
|
|
|
- CHUK
- FIP3
- IKBKB
- IKBKG
- IKKA
- IKKB
- NEMO
- TCF16
|
|
Acyl chain remodelling of PE
|
|
|
- ABHD4
- AGPAT7
- AYTL3
- CLEC13C
- CPLA2
- HRASLS
- HRASLS2
- HRASLS3
- HRASLS5
- HREV107
- HRLP5
- IPLA22
- IPLA2G
- LPCAT3
- LPCAT4
- LPEAT2
- MBOAT1
- MBOAT2
- MBOAT5
- OACT1
- OACT2
- OACT5
- PLA2
- PLA2A
- PLA2B
- PLA2G10
- PLA2G12
- PLA2G12A
- PLA2G16
- PLA2G1B
- PLA2G2A
- PLA2G2D
- PLA2G2E
- PLA2G2F
- PLA2G3
- PLA2G4
- PLA2G4A
- PLA2G4B
- PLA2G4C
- PLA2G4D
- PLA2G4E
- PLA2G4F
- PLA2G5
- PLA2G6
- PLA2L
- PLA2R1
- PLAAT1
- PLAAT2
- PLAAT3
- PLAAT4
- PLAAT5
- PLBD1
- PLPLA9
- PNPLA8
- PPLA2
- RARRES3
- RASF-A
- RIG1
- SPLASH
- TIG3
|
|
Plus-strand DNA synthesis
|
|
|
- CYPA
- PPIA
- gag
- gag-pol
- rev
- vif
- vpr
- vpu
|
|
G2 Phase
|
|
|
- CCN1
- CCNA
- CCNA1
- CCNA2
- CDK2
- CDKN2
- E2F1
- E2F3
- KIAA0075
- RBBP3
|
|
NOTCH3 Activation and Transmission of Signal to the Nucleus
|
|
|
- AD3
- AD4
- ADAM10
- APH1A
- APH1B
- DIP1
- DLL1
- DLL4
- EGF
- EGFR
- ERBB
- ERBB1
- ERIC1
- HER1
- JAG1
- JAG2
- JAGL1
- KIAA0253
- KIAA1323
- KUZ
- MADM
- MIB1
- MIB2
- NCSTN
- NEURL
- NEURL1
- NEURL1A
- NEURL1B
- NEURL3
- NOTCH3
- PEN2
- PS1
- PS2
- PSEN1
- PSEN2
- PSENEN
- PSF
- PSFL
- PSNL1
- PSNL2
- RNF67
- RPS27A
- SKD
- STM2
- TACC3
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- WWP2
- ZZANK1
- ZZANK2
|
|
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)
|
|
|
|
|
FLT3 Signaling
|
|
|
- AKT1
- AKT2
- AKT3
- BCL2L11
- BIM
- CD135
- CDKN1B
- FKHRL1
- FLK2
- FLT3
- FLT3LG
- FOXO3
- FOXO3A
- GAB2
- GADS
- GRAP2
- GRB1
- GRB10
- GRB2L
- GRBIR
- GRID
- HRAS
- HRAS1
- KIAA0207
- KIAA0571
- KIP1
- NRAS
- PIK3CA
- PIK3R1
- PKB
- PKBG
- PTP2C
- PTPN11
- RAC
- SHPTP2
- SOS1
- STK1
- p27
|
|
NPAS4 regulates expression of target genes
|
|
|
- ARNT
- ARNT2
- ARNTL
- BDNF
- BHLHE1
- BHLHE2
- BHLHE5
- BHLHE79
- BMAL1
- CBP
- CDHF12
- CDHR16
- CDK5
- CDK5R
- CDK5R1
- CDKN5
- CREBBP
- CRM1
- ERK1
- ERK2
- FOS
- G0S7
- GEM
- INS
- IQSEC3
- KIAA0307
- KIAA1110
- KIR
- MAPK1
- MAPK3
- MDM2
- MOP3
- NAMPT
- NCK5A
- NPAS4
- NXF
- PASD10
- PASD3
- PBEF
- PBEF1
- PLK2
- PRKM1
- PRKM2
- PRKM3
- PSSALRE
- PTC
- RBFOX3
- RET
- SNK
- SYT10
- XPO1
|
|
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
|
- CDK-activating kinase assembly factor MAT1
- Cullin-4A
- Cullin-4B
- Cyclin-H
- Cyclin-dependent kinase 7
- DNA damage-binding protein 1
- DNA excision repair protein ERCC-6
- DNA excision repair protein ERCC-8
- DNA-directed RNA polymerase II subunit RPB11-a
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerase II subunit RPB2
- DNA-directed RNA polymerase II subunit RPB3
- DNA-directed RNA polymerase II subunit RPB4
- DNA-directed RNA polymerase II subunit RPB7
- DNA-directed RNA polymerase II subunit RPB9
- DNA-directed RNA polymerases I, II, and III subunit RPABC1
- DNA-directed RNA polymerases I, II, and III subunit RPABC2
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- DNA-directed RNA polymerases I, II, and III subunit RPABC4
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- E3 ubiquitin-protein ligase RBX1
- General transcription and DNA repair factor IIH helicase subunit XPD
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- General transcription factor IIH subunit 1
- General transcription factor IIH subunit 2
- General transcription factor IIH subunit 3
- General transcription factor IIH subunit 4
- General transcription factor IIH subunit 5
- Peptidyl-prolyl cis-trans isomerase E
- Polyubiquitin-B
- Polyubiquitin-C
- Pre-mRNA-processing factor 19
- Pre-mRNA-splicing factor ISY1 homolog
- Pre-mRNA-splicing factor SYF1
- RNA helicase aquarius
- RNA polymerase II elongation factor ELL
- Transcription elongation factor A protein 1
- UV-stimulated scaffold protein A
- Ubiquitin carboxyl-terminal hydrolase 7
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- Zinc finger protein 830
|
|
- AQR
- BTF2
- BTF2P44
- C19orf17
- C6orf175
- CAK
- CAK1
- CAP35
- CCDC16
- CCNH
- CDK7
- CDKN7
- CKN1
- CSA
- CSB
- CUL4A
- CUL4B
- CYP33
- DDB1
- ELL
- ERCC2
- ERCC3
- ERCC6
- ERCC8
- GTF2H1
- GTF2H2
- GTF2H3
- GTF2H4
- GTF2H5
- GTF2S
- HAUSP
- HCNP
- ISY1
- KIAA0560
- KIAA0695
- KIAA1160
- KIAA1177
- KIAA1530
- MAT1
- MNAT1
- MO15
- NMP200
- POLR2
- POLR2A
- POLR2B
- POLR2C
- POLR2D
- POLR2E
- POLR2F
- POLR2G
- POLR2H
- POLR2I
- POLR2J
- POLR2J1
- POLR2K
- POLR2L
- POLRF
- PPIE
- PRP19
- PRPF19
- RBX1
- RNF66
- RNF75
- ROC1
- RPB7
- RPS27A
- SNEV
- STK1
- SYF1
- TCEA1
- TFIIS
- TTDA
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- USP7
- UVSSA
- XAB2
- XAP1
- XPB
- XPBC
- XPD
- XPDC
- ZNF830
|
|
Synthesis of PA
|
|
|
- ACP6
- ACPL1
- AGPAT1
- AGPAT2
- AGPAT3
- AGPAT4
- AGPAT5
- AGPAT6
- AGPAT7
- AGPAT8
- AGPAT9
- ALCAT1
- ALPI
- AYTL2
- AYTL3
- C9orf54
- CLEC13C
- CPLA2
- DAPAT
- DDHD1
- DDHD2
- DHAPAT
- FAM73A
- FAM73B
- G15
- GNPAT
- GPAM
- GPAT1
- GPAT2
- GPAT3
- GPAT4
- GPD1
- GPD1L
- GPD2
- KIAA0089
- KIAA0725
- KIAA1560
- KIAA1705
- LCLAT1
- LIPH
- LIPI
- LPAAT3
- LPAP
- LPCAT1
- LPCAT4
- LPDL
- LPDLR
- LPEAT2
- LYCAT
- MAG1
- MIGA1
- MIGA2
- MPAPLA1
- PFAAP3
- PLA1B
- PLA2
- PLA2A
- PLA2B
- PLA2G10
- PLA2G12
- PLA2G12A
- PLA2G1B
- PLA2G2A
- PLA2G2D
- PLA2G2E
- PLA2G2F
- PLA2G4
- PLA2G4A
- PLA2G4B
- PLA2G4D
- PLA2G5
- PLA2L
- PLA2R1
- PLD1
- PLD2
- PLD6
- PPLA2
- RASF-A
- SAMWD1
- SPLASH
- TSARG7
|
|
Signaling by FGFR2 in disease
|
|
|
- BEK
- FGF1
- FGF10
- FGF16
- FGF18
- FGF2
- FGF20
- FGF22
- FGF23
- FGF3
- FGF4
- FGF6
- FGF7
- FGF9
- FGFA
- FGFB
- FGFR2
- FRS2
- GAB1
- GRB1
- HRAS
- HRAS1
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- INT2
- KGF
- KGFR
- KS3
- KSAM
- NRAS
- PIK3CA
- PIK3R1
- PLC1
- PLCG1
- SOS1
|
|
Selenocysteine synthesis
|
|
|
- BBC1
- C10orf89
- CCG2
- D11S2243E
- D6S218E
- DXS648E
- EC45
- EEFSEC
- FAU
- FTE1
- LAMBR
- LAMR1
- MFTL
- MPS1
- NEDD6
- PSTK
- QM
- RIG
- RPL1
- RPL10
- RPL10A
- RPL10L
- RPL11
- RPL12
- RPL13
- RPL13A
- RPL14
- RPL15
- RPL17
- RPL18
- RPL18A
- RPL19
- RPL21
- RPL22
- RPL22L1
- RPL23
- RPL23A
- RPL24
- RPL26
- RPL26L1
- RPL26P1
- RPL27
- RPL27A
- RPL28
- RPL29
- RPL3
- RPL30
- RPL31
- RPL32
- RPL34
- RPL35
- RPL35A
- RPL36
- RPL36A
- RPL36AL
- RPL37
- RPL37A
- RPL38
- RPL39
- RPL39L
- RPL39L1
- RPL3L
- RPL4
- RPL41
- RPL44
- RPL5
- RPL6
- RPL7
- RPL7A
- RPL8
- RPL9
- RPL9P7
- RPL9P8
- RPL9P9
- RPLP0
- RPLP1
- RPLP2
- RPP2
- RPS10
- RPS11
- RPS12
- RPS13
- RPS14
- RPS15
- RPS15A
- RPS16
- RPS17
- RPS17L
- RPS18
- RPS19
- RPS2
- RPS20
- RPS21
- RPS23
- RPS24
- RPS25
- RPS26
- RPS27
- RPS27A
- RPS27L
- RPS28
- RPS29
- RPS3
- RPS3A
- RPS4
- RPS4X
- RPS4Y
- RPS4Y1
- RPS4Y2
- RPS4Y2P
- RPS5
- RPS6
- RPS7
- RPS8
- RPS9
- RPSA
- RRP1
- SARS
- SARS1
- SBP2
- SCAR
- SECISBP2
- SELB
- SEPHS2
- SEPSECS
- SERS
- SPS2
- SURF-3
- SURF3
- TRNP48
- TXREB1
- UBA52
- UBA80
- UBCEP1
- UBCEP2
|
|
Vitamin B6 activation to pyridoxal phosphate
|
|
|
- AO
- AOX1
- C21orf124
- C21orf97
- PDXK
- PKH
- PNK
- PNPO
|
|
Inhibition of PKR
|
|
|
|
|
Negative regulation of FGFR4 signaling
|
|
|
- CBL
- CBL2
- ERK1
- ERK2
- FGF1
- FGF16
- FGF18
- FGF19
- FGF2
- FGF20
- FGF23
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- FGFR4
- FRS2
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- JTK2
- KLB
- KS3
- MAPK1
- MAPK3
- PRKM1
- PRKM2
- PRKM3
- PTP2C
- PTPN11
- RNF55
- RPS27A
- SHPTP2
- TKF
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Polo-like kinase mediated events
|
|
|
- BARA
- BMYB
- C14orf46
- CCNB
- CCNB1
- CCNB2
- CDC25A
- CDC25C
- CENPF
- CXCDC1
- EP300
- FKHL16
- FOXM1
- HFH11
- KIAA2037
- LIN37
- LIN52
- LIN54
- LIN9
- MPP2
- MYBL2
- MYT1
- P300
- PKMYT1
- PLK
- PLK1
- RBAP48
- RBBP4
- TGS
- WEE1
- WIN
|
|
Calmodulin induced events
|
|
|
- ADRBK1
- BARK
- BARK1
- CALM
- CALM1
- CAM
- CAM1
- GRK2
- PKCA
- PKCD
- PKCG
- PRKACA
- PRKCA
- PRKCD
- PRKCG
|
|
Regulation of commissural axon pathfinding by SLIT and ROBO
|
|
|
- DCC
- DUTT1
- IGDCC1
- KIAA0813
- KIAA0814
- KIAA1568
- MEGF4
- MEGF5
- NELL2
- NRP2
- NTN1
- NTN1L
- ROBO1
- ROBO2
- SLIL1
- SLIL2
- SLIL3
- SLIT1
- SLIT2
- SLIT3
- SRC
- SRC1
|
|
RHO GTPases Activate Rhotekin and Rhophilins
|
|
|
- ARH12
- ARH6
- ARH9
- ARHA
- ARHB
- ARHC
- KIAA1929
- LIN7B
- MALS2
- RHO12
- RHOA
- RHOB
- RHOC
- RHPN1
- RHPN2
- ROPN1
- ROPN1A
- RTKN
- RTKN1
- TAX1BP3
- TIP1
- VELI2
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