GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **951 - 975** of **2074** in total

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Pathway Name	Protein Name ▲	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Defective LARGE causes MDDGA6 and MDDGB6	Beta-1,4-glucuronyltransferase 1 Xylosyl- and glucuronyltransferase LARGE1	O43505 O95461	B3GNT1 B3GNT6 B4GAT1 KIAA0609 LARGE LARGE1	Homo sapiens (human)
Reactions specific to the hybrid N-glycan synthesis pathway	Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Q09327	GGNT3 MGAT3	Homo sapiens (human)
DAP12 interactions	Beta-2-microglobulin C-type lectin domain family 5 member A CMRF35-like molecule 2 CMRF35-like molecule 7 HLA class I histocompatibility antigen, B alpha chain HLA class I histocompatibility antigen, C alpha chain HLA class I histocompatibility antigen, alpha chain E Killer cell immunoglobulin-like receptor 2DS2 Killer cell immunoglobulin-like receptor 2DS4 Killer cell immunoglobulin-like receptor 2DS5 Killer cell immunoglobulin-like receptor 3DS1 NKG2-C type II integral membrane protein NKG2-D type II integral membrane protein Natural cytotoxicity triggering receptor 2 Natural killer cells antigen CD94 Sialic acid-binding Ig-like lectin 14 Sialic acid-binding Ig-like lectin 15 Sialic acid-binding Ig-like lectin 16 Signal-regulatory protein beta-1 TYRO protein tyrosine kinase-binding protein Triggering receptor expressed on myeloid cells 1 Triggering receptor expressed on myeloid cells 2	A6NMB1 A8K4G0 O00241 O43914 O95944 P01889 P10321 P13747 P26717 P26718 P43631 P43632 P61769 Q08ET2 Q13241 Q14943 Q14953 Q496F6 Q6ZMC9 Q9NP99 Q9NY25 Q9NZC2	B2M CD158G CD158I CD158J CD300B CD300E CD300LB CD300LE CD33L3 CD94 CLEC5A CLECSF5 CLM2 CLM7 CMRF35A2 CMRF35A5 D12S2489E DAP12 HLA-6.2 HLA-B HLA-C HLA-E HLAB HLAC HLAE IREM2 IREM3 KARAP KIR2DS2 KIR2DS4 KIR2DS5 KIR3DS1 KKA3 KLRC2 KLRD1 KLRK1 LMIR5 LY95 MDL1 NCR2 NKAT10 NKAT5 NKAT8 NKAT9 NKG2C NKG2D SIGLEC14 SIGLEC15 SIGLEC16 SIGLECP16 SIRPB1 TREM1 TREM2 TREM5 TYROBP	Homo sapiens (human)
Endosomal/Vacuolar pathway	Beta-2-microglobulin Cathepsin L2 Cathepsin S HLA class I histocompatibility antigen, A alpha chain HLA class I histocompatibility antigen, B alpha chain HLA class I histocompatibility antigen, C alpha chain HLA class I histocompatibility antigen, alpha chain E HLA class I histocompatibility antigen, alpha chain F HLA class I histocompatibility antigen, alpha chain G Leucyl-cystinyl aminopeptidase Procathepsin L Putative HLA class I histocompatibility antigen, alpha chain H	O60911 P01889 P01893 P04439 P07711 P10321 P13747 P17693 P25774 P30511 P61769 Q9UIQ6	B2M CATL2 CTSL CTSL1 CTSL2 CTSS CTSU CTSV HLA-5.4 HLA-6.0 HLA-6.2 HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HLA-H HLAA HLAB HLAC HLAE HLAF HLAG HLAH LNPEP OTASE	Homo sapiens (human)
Activation of SMO	Beta-adrenergic receptor kinase 1 Beta-arrestin-1 Beta-arrestin-2 Brother of CDO Casein kinase I isoform alpha Cell adhesion molecule-related/down-regulated by oncogenes Desert hedgehog protein Dynein regulatory complex subunit 4 EF-hand calcium-binding domain-containing protein 7 EvC complex member EVC Growth arrest-specific protein 1 IQ domain-containing protein E Indian hedgehog protein Kinesin-like protein KIF3A Limbin Protein patched homolog 1 Protein smoothened Sonic hedgehog protein	A8K855 O43323 O95995 P25098 P32121 P48729 P49407 P54826 P57679 Q13635 Q14623 Q15465 Q4KMG0 Q6IPM2 Q86UK5 Q99835 Q9BWV1 Q9Y496	ADRBK1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BARK BARK1 BOC CDO CDON CSNK1A1 DHH DRC4 EFCAB7 EVC EVC2 GAS1 GAS11 GAS8 GRK2 IHH IQCE KIAA1023 KIAA1799 KIF3 KIF3A LBN PTCH PTCH1 SHH SMO SMOH	Homo sapiens (human)
Calmodulin induced events	Beta-adrenergic receptor kinase 1 Calmodulin-1 Protein kinase C alpha type Protein kinase C delta type Protein kinase C gamma type	P05129 P0DP23 P17252 P25098 Q05655	ADRBK1 BARK BARK1 CALM CALM1 CAM CAM1 GRK2 PKCA PKCD PKCG PRKACA PRKCA PRKCD PRKCG	Homo sapiens (human)
Activated NOTCH1 Transmits Signal to the Nucleus	Beta-arrestin-1 Beta-arrestin-2 Contactin-1 Delta and Notch-like epidermal growth factor-related receptor Delta-like protein 1 Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 Disintegrin and metalloproteinase domain-containing protein 17 E3 ubiquitin-protein ligase DTX1 E3 ubiquitin-protein ligase DTX4 E3 ubiquitin-protein ligase Itchy homolog E3 ubiquitin-protein ligase MIB1 E3 ubiquitin-protein ligase MIB2 E3 ubiquitin-protein ligase NEURL1 E3 ubiquitin-protein ligase NEURL1B Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Neurogenic locus notch homolog protein 1 Nicastrin Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Probable E3 ubiquitin-protein ligase DTX2 Protein delta homolog 1 Protein jagged-1 Protein jagged-2 Protein numb homolog Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A8MQ27 O00548 O14672 O76050 P0CG47 P0CG48 P32121 P46531 P49407 P49757 P49768 P49810 P62979 P62987 P78504 P78536 P80370 Q12860 Q86UW9 Q86Y01 Q86YT6 Q8NFT8 Q8WW43 Q92542 Q96AX9 Q96BI3 Q96J02 Q9NR61 Q9NZ42 Q9Y219 Q9Y2E6	AD3 AD4 ADAM10 ADAM17 APH1A APH1B ARB2 ARR1 ARR2 ARRB1 ARRB2 BET C14orf41 CNTN1 CSVP DIP1 DLK DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 ITCH JAG1 JAG2 JAGL1 KIAA0253 KIAA0937 KIAA1323 KIAA1528 KUZ MADM MIB1 MIB2 NCSTN NEURL NEURL1 NEURL1A NEURL1B NEURL3 NOTCH1 NUMB PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RNF155 RNF58 RNF67 RPS27A SKD STM2 TACE TAN1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 ZZANK1 ZZANK2	Homo sapiens (human)
Thrombin signalling through proteinase activated receptors (PARs)	Beta-arrestin-1 Beta-arrestin-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(q) subunit alpha Guanine nucleotide-binding protein subunit alpha-11 Guanine nucleotide-binding protein subunit alpha-12 Guanine nucleotide-binding protein subunit alpha-13 Guanine nucleotide-binding protein subunit alpha-14 Guanine nucleotide-binding protein subunit alpha-15 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Proteinase-activated receptor 1 Proteinase-activated receptor 3 Proteinase-activated receptor 4 Prothrombin	O00254 O14610 O14775 O60262 O95837 P00734 P16520 P25116 P27361 P28482 P29992 P30679 P32121 P49407 P50148 P50150 P50151 P59768 P61952 P62873 P62879 P63211 P63215 P63218 Q03113 Q14344 Q96RI0 Q9HAV0 Q9P2W3 Q9UBI6 Q9UK08	ARB2 ARR1 ARR2 ARRB1 ARRB2 CF2R ERK1 ERK2 F2 F2R F2RL2 F2RL3 GA11 GAQ GNA11 GNA12 GNA13 GNA14 GNA15 GNA16 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 MAPK1 MAPK3 PAR1 PAR3 PAR4 PRKM1 PRKM2 PRKM3 TR	Homo sapiens (human)
TGFBR3 regulates TGF-beta signaling	Beta-arrestin-1 Beta-arrestin-2 PDZ domain-containing protein GIPC1 TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta receptor type 3 Transforming growth factor beta-1 proprotein Transforming growth factor beta-2 proprotein	O14908 P01137 P32121 P36897 P37173 P49407 P61812 Q03167	ALK5 ARB2 ARR1 ARR2 ARRB1 ARRB2 C19orf3 GIPC GIPC1 RGS19IP1 SKR4 TGFB TGFB1 TGFB2 TGFBR1 TGFBR2 TGFBR3	Homo sapiens (human)
Beta defensins	Beta-defensin (Fragment) Beta-defensin 103 Beta-defensin 104 Beta-defensin 105 Beta-defensin 106 Beta-defensin 107 Beta-defensin 108B Beta-defensin 110 Beta-defensin 112 Beta-defensin 113 Beta-defensin 114 Beta-defensin 115 Beta-defensin 116 Beta-defensin 119 Beta-defensin 121 Beta-defensin 123 Beta-defensin 124 Beta-defensin 125 Beta-defensin 126 Beta-defensin 127 Beta-defensin 128 Beta-defensin 129 Beta-defensin 130A Beta-defensin 130B Beta-defensin 131A Beta-defensin 132 Beta-defensin 133 Beta-defensin 134 Beta-defensin 135 Beta-defensin 1 C-C chemokine receptor type 2 C-C chemokine receptor type 6 Defensin beta 118 Defensin beta 136 Defensin beta 4A Putative beta-defensin 108A Putative beta-defensin 109B Toll-like receptor 1 Toll-like receptor 2	A8MXU0 O15263 O60603 P0DP73 P0DP74 P41597 P51684 P59861 P60022 P81534 Q15399 Q30KP8 Q30KP9 Q30KQ1 Q30KQ3 Q30KQ4 Q30KQ5 Q30KQ6 Q30KQ7 Q30KQ8 Q30KQ9 Q30KR1 Q4QY38 Q5J5C9 Q7Z7B7 Q7Z7B8 Q8IZN7 Q8N104 Q8N687 Q8N688 Q8N690 Q8NES8 Q8NET1 Q8NG35 Q8WTQ1 Q96PH6 Q9BYW3 Q9H1M3 Q9H1M4	BD1 BD3 BD5 BD6 C20orf63 C20orf73 C20orf8 C20orf87 CCR2 CCR6 CKRL3 CMKBR2 CMKBR6 DEFB1 DEFB10 DEFB102 DEFB103 DEFB103A DEFB103B DEFB104 DEFB104A DEFB104B DEFB105 DEFB105A DEFB105B DEFB106 DEFB106A DEFB106B DEFB107 DEFB107A DEFB107B DEFB108 DEFB108A DEFB108B DEFB108C DEFB108P1 DEFB108P2 DEFB109B DEFB109P1B DEFB11 DEFB110 DEFB111 DEFB112 DEFB113 DEFB114 DEFB115 DEFB116 DEFB117 DEFB118 DEFB119 DEFB12 DEFB120 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB13 DEFB130 DEFB130A DEFB130B DEFB131 DEFB131A DEFB132 DEFB133 DEFB134 DEFB135 DEFB136 DEFB14 DEFB15 DEFB16 DEFB18 DEFB19 DEFB2 DEFB20 DEFB21 DEFB23 DEFB24 DEFB25 DEFB26 DEFB27 DEFB28 DEFB29 DEFB3 DEFB30 DEFB31 DEFB32 DEFB4 DEFB4A DEFB4B DEFB5 DEFB6 DEFB7 DEFB8 ESC42 GPR29 HBD1 KIAA0012 STRL22 TIL4 TLR1 TLR2	Homo sapiens (human)
Defensins	Beta-defensin (Fragment) Beta-defensin 103 Beta-defensin 104 Beta-defensin 105 Beta-defensin 106 Beta-defensin 107 Beta-defensin 108B Beta-defensin 110 Beta-defensin 112 Beta-defensin 113 Beta-defensin 114 Beta-defensin 115 Beta-defensin 116 Beta-defensin 119 Beta-defensin 121 Beta-defensin 123 Beta-defensin 124 Beta-defensin 125 Beta-defensin 126 Beta-defensin 127 Beta-defensin 128 Beta-defensin 129 Beta-defensin 130A Beta-defensin 130B Beta-defensin 131A Beta-defensin 132 Beta-defensin 133 Beta-defensin 134 Beta-defensin 135 Beta-defensin 1 Defensin alpha 4 Defensin alpha 5 Defensin beta 118 Defensin beta 136 Defensin beta 4A Defensin-6 Neutrophil defensin 1 Neutrophil defensin 3	O15263 P0DP73 P0DP74 P12838 P59665 P59666 P59861 P60022 P81534 Q01523 Q01524 Q30KP8 Q30KP9 Q30KQ1 Q30KQ3 Q30KQ4 Q30KQ5 Q30KQ6 Q30KQ7 Q30KQ8 Q30KQ9 Q4QY38 Q5J5C9 Q7Z7B7 Q7Z7B8 Q8IZN7 Q8N104 Q8N687 Q8N688 Q8N690 Q8NES8 Q8NET1 Q8NG35 Q8WTQ1 Q96PH6 Q9BYW3 Q9H1M3 Q9H1M4	BD1 BD3 BD5 BD6 C20orf63 C20orf73 C20orf8 C20orf87 DEF1 DEF3 DEF4 DEF5 DEF6 DEFA1 DEFA1B DEFA2 DEFA3 DEFA4 DEFA5 DEFA6 DEFB1 DEFB10 DEFB102 DEFB103 DEFB103A DEFB103B DEFB104 DEFB104A DEFB104B DEFB105 DEFB105A DEFB105B DEFB106 DEFB106A DEFB106B DEFB107 DEFB107A DEFB107B DEFB108 DEFB108B DEFB11 DEFB110 DEFB111 DEFB112 DEFB113 DEFB114 DEFB115 DEFB116 DEFB117 DEFB118 DEFB119 DEFB12 DEFB120 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB13 DEFB130 DEFB130A DEFB130B DEFB131 DEFB131A DEFB132 DEFB133 DEFB134 DEFB135 DEFB136 DEFB14 DEFB15 DEFB16 DEFB18 DEFB19 DEFB2 DEFB20 DEFB21 DEFB23 DEFB24 DEFB25 DEFB26 DEFB27 DEFB28 DEFB29 DEFB3 DEFB30 DEFB31 DEFB32 DEFB4 DEFB4A DEFB4B DEFB5 DEFB6 DEFB7 DEFB8 ESC42 HBD1 MRS	Homo sapiens (human)
Defective NEU1 causes sialidosis	Beta-galactosidase Lysosomal protective protein Sialidase-1	P10619 P16278 Q99519	CTSA ELNR1 GLB1 NANH NEU1 PPGB	Homo sapiens (human)
MPS IV - Morquio syndrome B	Beta-galactosidase	P16278	ELNR1 GLB1	Homo sapiens (human)	G82768YB
Hyaluronan uptake and degradation	Beta-glucuronidase Beta-hexosaminidase subunit alpha Beta-hexosaminidase subunit beta CD44 antigen Calcineurin B homologous protein 1 Hyaluronan mediated motility receptor Hyaluronidase-1 Hyaluronidase-2 Hyaluronidase-3 Lymphatic vessel endothelial hyaluronic acid receptor 1 Sodium/hydrogen exchanger 1 Stabilin-2	O43820 O75330 P06865 P07686 P08236 P16070 P19634 Q12794 Q12891 Q8WWQ8 Q99653 Q9Y5Y7	APNH1 CD44 CHP CHP1 CRSBP1 FEEL2 FELL FEX2 GUSB HAR HARE HEXA HEXB HMMR HYAL1 HYAL2 HYAL3 IHABP LHR LUCA1 LUCA2 LUCA3 LYVE1 MDU2 MDU3 MIC4 NHE1 RHAMM SLC9A1 STAB2 XLKD1	Homo sapiens (human)	G35674CY
MPS VII - Sly syndrome	Beta-glucuronidase	P08236	GUSB	Homo sapiens (human)	G35674CY
Defective HEXA causes GM2G1	Beta-hexosaminidase subunit alpha	P06865	HEXA	Homo sapiens (human)	G20239CJ
Defective HEXB causes GM2G2	Beta-hexosaminidase subunit beta	P07686	HEXB	Homo sapiens (human)	G20239CJ
Negative regulation of FGFR4 signaling	Beta-klotho E3 ubiquitin-protein ligase CBL Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Polyubiquitin-B Polyubiquitin-C Tyrosine-protein phosphatase non-receptor type 11 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O43320 O76093 O95750 P05230 P08620 P09038 P0CG47 P0CG48 P10767 P22455 P22681 P27361 P28482 P31371 P62979 P62987 Q06124 Q86Z14 Q8WU20 Q9GZV9 Q9NP95	CBL CBL2 ERK1 ERK2 FGF1 FGF16 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF9 FGFA FGFB FGFR4 FRS2 HST HST2 HSTF1 HSTF2 HYPF JTK2 KLB KS3 MAPK1 MAPK3 PRKM1 PRKM2 PRKM3 PTP2C PTPN11 RNF55 RPS27A SHPTP2 TKF UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
PI3K Cascade	Beta-klotho Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Insulin receptor substrate 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphoinositide 3-kinase regulatory subunit 4 Receptor-type tyrosine-protein kinase FLT3 Toll-like receptor 9 Tyrosine-protein phosphatase non-receptor type 11	O00459 O15520 O43320 O76093 O95750 P05230 P08620 P09038 P10767 P11487 P21781 P22455 P27986 P31371 P35568 P36888 P42336 P42338 P49771 Q06124 Q13480 Q86Z14 Q8NEB9 Q8WU20 Q99570 Q9GZV9 Q9HCT0 Q9NP95 Q9NR96 Q9UQC2 Q9Y4H2	CD135 FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 GAB1 GAB2 GRB1 HST HST2 HSTF1 HSTF2 HYPF INT2 IRS1 IRS2 JTK2 KGF KIAA0571 KLB KS3 PIK3C1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTP2C PTPN11 SHPTP2 STK1 TKF TLR9 VPS15 VPS34	Homo sapiens (human)
FRS-mediated FGFR4 signaling	Beta-klotho Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 GTPase HRas GTPase NRas Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	O43320 O43559 O76093 O95750 P01111 P01112 P05230 P08620 P09038 P10767 P22455 P31371 Q06124 Q07889 Q86Z14 Q8WU20 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF9 FGFA FGFB FGFR4 FRS2 FRS3 HRAS HRAS1 HST HST2 HSTF1 HSTF2 HYPF JTK2 KLB KS3 NRAS PTP2C PTPN11 SHPTP2 SOS1 TKF	Homo sapiens (human)
PI-3K cascade:FGFR4	Beta-klotho Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 GRB2-associated-binding protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	O43320 O76093 O95750 P05230 P08620 P09038 P10767 P22455 P27986 P31371 P42336 Q06124 Q13480 Q86Z14 Q8WU20 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF9 FGFA FGFB FGFR4 FRS2 GAB1 GRB1 HST HST2 HSTF1 HSTF2 HYPF JTK2 KLB KS3 PIK3CA PIK3R1 PTP2C PTPN11 SHPTP2 TKF	Homo sapiens (human)
SHC-mediated cascade:FGFR4	Beta-klotho Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 GTPase HRas GTPase NRas Son of sevenless homolog 1	O43320 O76093 O95750 P01111 P01112 P05230 P08620 P09038 P10767 P22455 P31371 Q07889 Q86Z14 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF9 FGFA FGFB FGFR4 HRAS HRAS1 HST HST2 HSTF1 HSTF2 HYPF JTK2 KLB KS3 NRAS SOS1 TKF	Homo sapiens (human)
betaKlotho-mediated ligand binding	Beta-klotho Fibroblast growth factor 19 Fibroblast growth factor receptor 4	O95750 P22455 Q86Z14	FGF19 FGFR4 JTK2 KLB TKF	Homo sapiens (human)
NRIF signals cell death from the nucleus	Beta-nerve growth factor Centromere protein R Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Mitogen-activated protein kinase 8 Nicastrin Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Sequestosome-1 TNF receptor-associated factor 6 Tumor necrosis factor receptor superfamily member 16 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P01138 P08138 P0CG47 P0CG48 P45983 P49768 P49810 P62979 P62987 Q13352 Q13501 Q8WW43 Q92542 Q96BI3 Q9NZ42 Q9Y4K3	AD3 AD4 APH1A APH1B CENPR ITGB3BP JNK1 KIAA0253 MAPK8 NCSTN NGF NGFB NGFR NRIF3 ORCA OSIL PEN2 PRKM8 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RNF85 RPS27A SAPK1 SAPK1C SQSTM1 STM2 TNFRSF16 TRAF6 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
NGF processing	Beta-nerve growth factor Furin Proprotein convertase subtilisin/kexin type 5 Proprotein convertase subtilisin/kexin type 6	P01138 P09958 P29122 Q92824	FUR FURIN NGF NGFB PACE PACE4 PC5 PC6 PCSK3 PCSK5 PCSK6	Homo sapiens (human)

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