GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **1026 - 1050** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲
Astrocytic Glutamate-Glutamine Uptake And Metabolism	Excitatory amino acid transporter 1 Excitatory amino acid transporter 2 Glutamine synthetase Sodium-coupled neutral amino acid symporter 1	P15104 P43003 P43004 Q9H2H9	ATA1 EAAT1 EAAT2 GLAST GLAST1 GLNS GLT1 GLUL NAT2 SAT1 SLC1A2 SLC1A3 SLC38A1 SNAT1
Cilium Assembly	Alpha-tubulin N-acetyltransferase 1 Histone deacetylase 6	Q5SQI0 Q9UBN7	ATAT1 C6orf134 HDAC6 KIAA0901 MEC17
Interferon gamma signaling	2'-5'-oligoadenylate synthase 1 2'-5'-oligoadenylate synthase 2 2'-5'-oligoadenylate synthase 3 2'-5'-oligoadenylate synthase-like protein Beta-2-microglobulin CD44 antigen Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma E3 ubiquitin-protein ligase Midline-1 E3 ubiquitin-protein ligase TRIM17 E3 ubiquitin-protein ligase TRIM21 E3 ubiquitin-protein ligase TRIM22 E3 ubiquitin-protein ligase TRIM31 E3 ubiquitin-protein ligase TRIM34 E3 ubiquitin-protein ligase TRIM35 E3 ubiquitin-protein ligase TRIM38 E3 ubiquitin-protein ligase TRIM45 E3 ubiquitin-protein ligase TRIM48 E3 ubiquitin-protein ligase TRIM62 E3 ubiquitin-protein ligase TRIM68 E3 ubiquitin-protein ligase TRIM8 E3 ubiquitin/ISG15 ligase TRIM25 Gamma-interferon-inducible lysosomal thiol reductase Guanylate-binding protein 1 Guanylate-binding protein 2 Guanylate-binding protein 3 Guanylate-binding protein 4 Guanylate-binding protein 5 Guanylate-binding protein 6 Guanylate-binding protein 7 HLA class I histocompatibility antigen, A alpha chain HLA class I histocompatibility antigen, B alpha chain HLA class I histocompatibility antigen, C alpha chain HLA class I histocompatibility antigen, alpha chain E HLA class I histocompatibility antigen, alpha chain F HLA class I histocompatibility antigen, alpha chain G HLA class II histocompatibility antigen, DP alpha 1 chain HLA class II histocompatibility antigen, DP beta 1 chain HLA class II histocompatibility antigen, DQ alpha 1 chain HLA class II histocompatibility antigen, DQ alpha 2 chain HLA class II histocompatibility antigen, DQ beta 1 chain HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DR alpha chain HLA class II histocompatibility antigen, DR beta 3 chain HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DRB1 beta chain High affinity immunoglobulin gamma Fc receptor I Intercellular adhesion molecule 1 Interferon gamma receptor 1 Interferon gamma receptor 2 Interferon gamma Interferon regulatory factor 1 Interferon regulatory factor 2 Interferon regulatory factor 3 Interferon regulatory factor 4 Interferon regulatory factor 5 Interferon regulatory factor 6 Interferon regulatory factor 7 Interferon regulatory factor 8 Interferon regulatory factor 9 MHC class II transactivator Metallothionein-2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mothers against decapentaplegic homolog 7 Neural cell adhesion molecule 1 Nuclear autoantigen Sp-100 Platelet-activating factor receptor Protein PML Protein kinase C delta type Putative HLA class I histocompatibility antigen, alpha chain H Putative high affinity immunoglobulin gamma Fc receptor IB Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tripartite motif-containing protein 10 Tripartite motif-containing protein 14 Tripartite motif-containing protein 26 Tripartite motif-containing protein 29 Tripartite motif-containing protein 2 Tripartite motif-containing protein 3 Tripartite motif-containing protein 46 Tripartite motif-containing protein 5 Tripartite motif-containing protein 6 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 6 Vascular cell adhesion protein 1 Y-box-binding protein 1	O00635 O14543 O14896 O15105 O15344 O15524 O60674 O75382 P00973 P01579 P01889 P01893 P01903 P01906 P01909 P01911 P01920 P02795 P04439 P04440 P05362 P05538 P10321 P10914 P12314 P13284 P13591 P13747 P13762 P14316 P15260 P16070 P17693 P19320 P19474 P20036 P23458 P23497 P25105 P27361 P28482 P29350 P29590 P29728 P30511 P32455 P32456 P33076 P38484 P61769 P67809 P79483 Q00978 Q02556 Q05655 Q12899 Q13554 Q13555 Q13557 Q13568 Q14134 Q14142 Q14258 Q14653 Q15306 Q15646 Q30154 Q6AZZ1 Q6ZN66 Q7Z4K8 Q8IWZ4 Q8IYM9 Q8N8V2 Q92637 Q92985 Q96PP8 Q96PP9 Q9BVG3 Q9BYJ4 Q9BZR9 Q9BZY9 Q9C030 Q9C035 Q9C040 Q9H0R5 Q9H8W5 Q9UDY6 Q9UPQ4 Q9UQM7 Q9Y577 Q9Y6K5	ATDC B2M BERP C6orf13 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CD44 CES1 CIITA CIS3 EFP ERK1 ERK2 FCG1 FCGR1 FCGR1A FCGR1B FCGR1BP FXY GBP1 GBP2 GBP3 GBP4 GBP4L GBP5 GBP6 GBP7 GC109 GERP GILT HCP HLA-5.4 HLA-6.0 HLA-6.2 HLA-A HLA-B HLA-C HLA-DP1A HLA-DP1B HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRA1 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-DXA HLA-DXB HLA-E HLA-F HLA-G HLA-H HLAA HLAB HLAC HLAE HLAF HLAG HLAH HLASB HLS5 ICAM1 ICSBP1 IFI30 IFNG IFNGR1 IFNGR2 IFNGT1 IFP1 IGFR1 IGFRB IP30 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 IRF9 ISGF3G JAK1 JAK1A JAK1B JAK2 KIAA0129 KIAA0517 KIAA0968 KIAA1098 LHR MADH7 MADH8 MAPK1 MAPK3 MDU2 MDU3 MHC2TA MIC4 MID1 MT2 MT2A MUM1 MYL NCAM NCAM1 NSEP1 OAS1 OAS2 OAS3 OASL OIAS PAFR PKCD PML PP8675 PRKCD PRKM1 PRKM2 PRKM3 PTAFR PTP1C PTPN6 RBCC RFB30 RNF RNF101 RNF137 RNF147 RNF15 RNF16 RNF21 RNF22 RNF27 RNF59 RNF71 RNF81 RNF86 RNF88 RNF89 RNF9 RNF94 RNF95 RNF97 RNF99 RO52 RORET SMAD7 SOCS1 SOCS3 SP100 SS56 SSA1 SSI1 SSI3 STAF50 TERF TIP3 TRIFIC TRIM10 TRIM14 TRIM17 TRIM18 TRIM19 TRIM2 TRIM21 TRIM22 TRIM25 TRIM26 TRIM29 TRIM3 TRIM31 TRIM34 TRIM35 TRIM38 TRIM45 TRIM46 TRIM48 TRIM5 TRIM6 TRIM62 TRIM68 TRIM8 TRIP14 VCAM1 XPRF YB1 YBX1 ZNF147 ZNF173
CREB phosphorylation	Cyclic AMP-dependent transcription factor ATF-1 MAP kinase-activated protein kinase 2 Ribosomal protein S6 kinase alpha-1 Ribosomal protein S6 kinase alpha-2 Ribosomal protein S6 kinase alpha-3 Ribosomal protein S6 kinase alpha-5	O75582 P18846 P49137 P51812 Q15349 Q15418	ATF1 ISPK1 MAPKAPK1A MAPKAPK1B MAPKAPK1C MAPKAPK2 MSK1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RSK1 RSK2 RSK3
TP53 Regulates Transcription of DNA Repair Genes	Breast cancer type 1 susceptibility protein CDK-activating kinase assembly factor MAT1 Cellular tumor antigen p53 Cyclic AMP-dependent transcription factor ATF-2 Cyclin-H Cyclin-K Cyclin-T1 Cyclin-T2 Cyclin-dependent kinase 12 Cyclin-dependent kinase 13 Cyclin-dependent kinase 7 Cyclin-dependent kinase 9 DNA damage-binding protein 2 DNA mismatch repair protein Mlh1 DNA mismatch repair protein Msh2 DNA repair protein RAD51 homolog 4 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Elongin-A2 Elongin-A Elongin-B Elongin-C FACT complex subunit SPT16 FACT complex subunit SSRP1 Fanconi anemia group C protein Fanconi anemia group D2 protein Fanconi anemia group I protein General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Mediator of DNA damage checkpoint protein 1 Mismatch repair endonuclease PMS2 Negative elongation factor A Negative elongation factor B Negative elongation factor C/D Negative elongation factor E Protein c-Fos RNA polymerase II elongation factor ELL RNA polymerase II subunit A C-terminal domain phosphatase Serine-protein kinase ATM Serine/threonine-protein kinase ATR Serine/threonine-protein kinase Chk1 Transcription elongation factor A protein 1 Transcription elongation factor SPT4 Transcription elongation factor SPT5 Transcription factor Jun	O00267 O14757 O15514 O60563 O60583 O75771 O75909 P01100 P04637 P05412 P13984 P15336 P18074 P18615 P19387 P19388 P19447 P23193 P24928 P30876 P32780 P35269 P36954 P38398 P40692 P43246 P50613 P50750 P51946 P51948 P52434 P52435 P53803 P54278 P55199 P61218 P62487 P62875 P63272 Q00597 Q08945 Q13315 Q13535 Q13888 Q13889 Q14004 Q14241 Q14676 Q15369 Q15370 Q6ZYL4 Q8IXH7 Q8IYF1 Q8WX92 Q92466 Q92759 Q9BXW9 Q9H3P2 Q9NVI1 Q9NYV4 Q9Y5B0 Q9Y5B9	ATF2 ATM ATR BRCA1 BTF2 BTF2P44 C19orf17 C6orf175 CAK CAK1 CAP35 CCNH CCNK CCNT1 CCNT2 CDC2L CDC2L4 CDC2L5 CDK12 CDK13 CDK7 CDK9 CDKN7 CHED CHEK1 CHK1 COBRA1 COCA2 CPR4 CREB2 CREBP1 CRK7 CRKRS CTDP1 DDB2 ELL ELOA ELOA2 ELOB ELOC ERCC2 ERCC3 FAC FACC FACD FACT140 FACT80 FACTP140 FANCC FANCD2 FANCI FCP1 FOS FRP1 G0S7 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2S JUN KIAA0170 KIAA0904 KIAA1182 KIAA1791 KIAA1794 MAT1 MDC1 MLH1 MNAT1 MO15 MSH2 NELFA NELFB NELFCD NELFD NELFE NFBD1 P53 PMS2 PMSL2 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF RAD51D RAD51L3 RAP30 RAP74 RD RDBP RNF53 RNF66 RPB7 SPT4H SPT5 SPT5H SSRP1 STK1 SUPT16H SUPT4H SUPT4H1 SUPT5H TAK TCEA1 TCEB1 TCEB2 TCEB3 TCEB3B TCEB3L TFIIS TH1 TH1L TP53 TTDA WHSC2 XPB XPBC XPD XPDC
Activation of the AP-1 family of transcription factors	Cyclic AMP-dependent transcription factor ATF-2 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Protein c-Fos Transcription factor Jun	P01100 P05412 P15336 P27361 P28482 P45983 P45984 P53779 Q15759 Q16539	ATF2 CREB2 CREBP1 CSBP CSBP1 CSBP2 CSPB1 ERK1 ERK2 FOS G0S7 JNK1 JNK2 JNK3 JNK3A JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MXI2 PRKM1 PRKM10 PRKM11 PRKM2 PRKM3 PRKM8 PRKM9 SAPK1 SAPK1A SAPK1B SAPK1C SAPK2 SAPK2A SAPK2B
ATF6 (ATF6-alpha) activates chaperone genes	Calreticulin Cyclic AMP-dependent transcription factor ATF-4 Cyclic AMP-dependent transcription factor ATF-6 alpha DNA damage-inducible transcript 3 protein Endoplasmic reticulum chaperone BiP Endoplasmin Nuclear transcription factor Y subunit alpha Nuclear transcription factor Y subunit beta Nuclear transcription factor Y subunit gamma	P11021 P14625 P18848 P18850 P23511 P25208 P27797 P35638 Q13952	ATF4 ATF6 CALR CHOP CHOP10 CREB2 CRTC DDIT3 GADD153 GRP78 GRP94 HAP3 HSP90B1 HSPA5 HSPC4 NFYA NFYB NFYC TRA1 TXREB
NFE2L2 regulating anti-oxidant/detoxification enzymes	CREB-binding protein Cyclic AMP-dependent transcription factor ATF-4 Cystine/glutamate transporter Extracellular superoxide dismutase [Cu-Zn] Glutamate--cysteine ligase catalytic subunit Glutamate--cysteine ligase regulatory subunit Glutathione S-transferase A1 Glutathione S-transferase A3 Heme oxygenase 1 Histone acetyltransferase p300 NAD(P)H dehydrogenase [quinone] 1 Nuclear factor erythroid 2-related factor 2 Peroxiredoxin-1 Sulfiredoxin-1 Thioredoxin reductase 1, cytoplasmic Thioredoxin Transcription factor MafK Transcription regulator protein BACH1	O14867 O60675 P08263 P08294 P09601 P10599 P15559 P18848 P48506 P48507 Q06830 Q09472 Q16236 Q16772 Q16881 Q92793 Q9BYN0 Q9UPY5	ATF4 BACH1 C20orf139 CBP CREB2 CREBBP DIA4 EP300 GCLC GCLM GLCL GLCLC GLCLR GRIM12 GSTA1 GSTA3 HMOX1 HO HO1 KDRF MAFK NFE2L2 NMOR1 NQO1 NRF2 P300 PAGA PAGB PRDX1 SLC7A11 SOD3 SRX SRX1 SRXN1 TDPX2 TRDX TRX TRX1 TXN TXNRD1 TXREB
NFE2L2 regulating ER-stress associated genes	CREB-binding protein Cyclic AMP-dependent transcription factor ATF-4 Histone acetyltransferase p300 Nuclear factor erythroid 2-related factor 2 Transcription factor MafK	O60675 P18848 Q09472 Q16236 Q92793	ATF4 CBP CREB2 CREBBP EP300 MAFK NFE2L2 NRF2 P300 TXREB
PERK regulates gene expression	Cyclic AMP-dependent transcription factor ATF-4 Endoplasmic reticulum chaperone BiP Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit 3 Eukaryotic translation initiation factor 2-alpha kinase 3	P05198 P11021 P18848 P20042 P41091 Q9NZJ5	ATF4 CREB2 EIF2A EIF2AK3 EIF2B EIF2G EIF2S1 EIF2S2 EIF2S3 GRP78 HSPA5 PEK PERK TXREB
ATF6 (ATF6-alpha) activates chaperones	Cyclic AMP-dependent transcription factor ATF-6 alpha Endoplasmic reticulum chaperone BiP Membrane-bound transcription factor site-1 protease Membrane-bound transcription factor site-2 protease	O43462 P11021 P18850 Q14703	ATF6 GRP78 HSPA5 KIAA0091 MBTPS1 MBTPS2 S1P S2P SKI1
ATF6B (ATF6-beta) activates chaperones	Cyclic AMP-dependent transcription factor ATF-6 beta Endoplasmic reticulum chaperone BiP Membrane-bound transcription factor site-1 protease Membrane-bound transcription factor site-2 protease	O43462 P11021 Q14703 Q99941	ATF6B CREBL1 G13 GRP78 HSPA5 KIAA0091 MBTPS1 MBTPS2 S1P S2P SKI1
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Regulator of telomere elongation helicase 1 Serine-protein kinase ATM	O15315 O43502 O43542 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9NZ71 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C20orf41 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 KIAA1088 MRE11 MRE11A NBN NBS NBS1 NHL P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 RTEL1 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2 XRCC3
HDR through Homologous Recombination (HRR)	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA polymerase eta DNA polymerase kappa DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O15315 O43502 O43542 O43543 O60934 O75771 P0CG47 P0CG48 P12004 P15927 P27694 P28340 P35244 P35249 P35250 P35251 P38398 P40937 P40938 P49005 P49959 P51530 P51587 P54132 P56282 P60896 P62979 P62987 Q06609 Q07864 Q13315 Q13472 Q14191 Q15054 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9HCU8 Q9NR33 Q9NRF9 Q9UBT6 Q9UQ84 Q9Y253	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CHRAC17 CTIP DINB1 DNA2 DNA2L DPE2 DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0039 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PCNA PIR51 POLD POLD1 POLD2 POLD3 POLD4 POLDS POLE POLE1 POLE2 POLE3 POLE4 POLH POLK RAD30 RAD30A RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RMI1 RMI2 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WRN XPV XRCC2 XRCC3
Homologous DNA Pairing and Strand Exchange	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43542 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2 XRCC3
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2
Impaired BRCA2 binding to PALB2	BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C9orf76 CTIP DNA2 DNA2L EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 TIP60 TOP3 TOP3A WRN XRCC2
Regulation of TP53 Activity through Methylation	Cellular tumor antigen p53 E3 ubiquitin-protein ligase Mdm2 Histone acetyltransferase p300 Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Junction-mediating and -regulatory protein Lethal(3)malignant brain tumor-like protein 1 N-lysine methyltransferase KMT5A N-lysine methyltransferase SMYD2 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Protein arginine N-methyltransferase 5 SET domain-containing protein 9 Serine-protein kinase ATM Serine/threonine-protein kinase Chk2 Tetratricopeptide repeat protein 5 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14744 O15151 O96017 P04637 P0CG47 P0CG48 P62979 P62987 Q00987 Q09472 Q13315 Q8N0Z6 Q8N9B5 Q8NE22 Q96KQ7 Q9H9B1 Q9NQR1 Q9NRG4 Q9Y468	ATM BAT8 C5orf35 C6orf30 CDS1 CHEK2 CHK2 EHMT1 EHMT2 EP300 EUHMTASE1 G9A GLP HRMT1L5 IBP72 JBP1 JMY KIAA0681 KIAA1876 KMT1C KMT1D KMT3C KMT5A L3MBT L3MBTL L3MBTL1 MDM2 MDM4 MDMX NG36 P300 P53 PRMT5 PRSET7 RAD53 RPS27A SET07 SET8 SETD8 SETD9 SKB1 SMYD2 TP53 TTC5 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
Meiotic recombination	Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 DNA endonuclease RBBP8 DNA mismatch repair protein Mlh1 DNA mismatch repair protein Mlh3 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 3 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.1t Histone H3.2 Histone H3.3 Histone H4 Histone-lysine N-methyltransferase PRDM9 Homologous-pairing protein 2 homolog Meiotic nuclear division protein 1 homolog Meiotic recombination protein DMC1/LIM15 homolog Meiotic recombination protein SPO11 MutS protein homolog 4 MutS protein homolog 5 Nibrin RecQ-like DNA helicase BLM Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Testis-expressed protein 15	O15457 O43196 O43502 O60814 O60934 P04908 P06899 P0C5Y9 P11802 P15927 P16104 P20671 P23527 P24941 P27694 P33778 P35244 P38398 P40692 P49959 P51587 P54132 P57053 P58876 P62805 P62807 P68431 P84243 Q06609 Q13315 Q13472 Q14565 Q16695 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8N257 Q92878 Q93077 Q93079 Q96A08 Q99708 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9BWT6 Q9BXT5 Q9NQV7 Q9P2W1 Q9UHC1 Q9Y5K1	ATM BLM BRCA1 BRCA2 CDK2 CDK4 CDKN2 COCA2 CTIP DMC1 DMC1H FACD FANCD1 GAJ H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3-4 H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H3FT H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 HNGS1 HOP2 LIM15 MLH1 MLH3 MND1 MRE11 MRE11A MSH4 MSH5 NBN NBS NBS1 P95 PFM6 PRDM9 PSMC3IP RAD50 RAD51 RAD51A RAD51C RAD51L2 RBBP8 RECA RECQ2 RECQL3 REPA1 REPA2 REPA3 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 SPO11 TBPIP TEX15 TOP3 TOP3A TSH2B
Stabilization of p53	Cellular tumor antigen p53 E3 ubiquitin-protein ligase Mdm2 PHD finger protein 20 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Serine-protein kinase ATM Serine/threonine-protein kinase Chk2 Tumor suppressor ARF Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O15151 O96017 P04637 P0CG47 P0CG48 P62979 P62987 Q00987 Q13315 Q8N726 Q9BVI0	ATM C20orf104 CDKN2 CDKN2A CDS1 CHEK2 CHK2 GLEA2 HCA58 MDM2 MDM4 MDMX MLM NZF P53 PHF20 RAD53 RPS27A TP53 TZP UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
Autodegradation of the E3 ubiquitin ligase COP1	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cellular tumor antigen p53 E3 ubiquitin-protein ligase COP1 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Serine-protein kinase ATM Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5LHX3 O00231 O00232 O00233 O00487 O14818 O43242 O75832 P04637 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62979 P62987 Q06323 Q13200 Q13315 Q14997 Q15008 Q16401 Q8NHY2 Q8TAA3 Q92530 Q99436 Q99460 Q9UL46 Q9UNM6	ATM C7orf76 COP1 DSS1 HC2 HC3 HC8 HC9 HSPC IFI5111 KIAA0072 KIAA0077 KIAA0107 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NU P53 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RFWD2 RING10 RING12 RNF200 RPS27A SEM1 SHFDG1 SHFM1 SUG1 SUG2 TBP1 TBP7 TP53 TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Y2 Z
Sensing of DNA Double Strand Breaks	DNA repair protein RAD50 Double-strand break repair protein MRE11 Histone acetyltransferase KAT5 Importin subunit alpha-1 Nibrin Serine-protein kinase ATM	O60934 P49959 P52292 Q13315 Q92878 Q92993	ATM HNGS1 HTATIP KAT5 KPNA2 MRE11 MRE11A NBN NBS NBS1 P95 RAD50 RCH1 SRP1 TIP60
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	Homeobox protein Nkx-2.2 Insulinoma-associated protein 1 Neurogenic differentiation factor 1 Neurogenin-3 Paired box protein Pax-4	O43316 O95096 Q01101 Q13562 Q9Y4Z2	ATOH5 BHLHA3 BHLHA7 IA1 INSM1 NEUROD NEUROD1 NEUROG3 NGN3 NKX2-2 NKX2.2 NKX2B PAX4

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