GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **1101 - 1125** of **2074** in total

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Pathway Name ▲	Protein Name	UniProt ID	Gene Symbol	Organism
NFE2L2 regulating ER-stress associated genes	CREB-binding protein Cyclic AMP-dependent transcription factor ATF-4 Histone acetyltransferase p300 Nuclear factor erythroid 2-related factor 2 Transcription factor MafK	O60675 P18848 Q09472 Q16236 Q92793	ATF4 CBP CREB2 CREBBP EP300 MAFK NFE2L2 NRF2 P300 TXREB	Homo sapiens (human)
NFE2L2 regulating MDR associated enzymes	ATP-binding cassette sub-family C member 3 ATP-binding cassette sub-family F member 2 Broad substrate specificity ATP-binding cassette transporter ABCG2 CREB-binding protein Histone acetyltransferase p300 Multidrug resistance-associated protein 1 Nuclear factor erythroid 2-related factor 2 Transcription factor MafK	O15438 O60675 P33527 Q09472 Q16236 Q92793 Q9UG63 Q9UNQ0	ABCC1 ABCC3 ABCF2 ABCG2 ABCP BCRP BCRP1 CBP CMOAT2 CREBBP EP300 MAFK MLP2 MRP MRP1 MRP3 MXR NFE2L2 NRF2 P300	Homo sapiens (human)
NFE2L2 regulating TCA cycle genes	Isocitrate dehydrogenase [NADP] cytoplasmic NADP-dependent malic enzyme Nuclear factor erythroid 2-related factor 2	O75874 P48163 Q16236	IDH1 ME1 NFE2L2 NRF2 PICD	Homo sapiens (human)
NFE2L2 regulating anti-oxidant/detoxification enzymes	CREB-binding protein Cyclic AMP-dependent transcription factor ATF-4 Cystine/glutamate transporter Extracellular superoxide dismutase [Cu-Zn] Glutamate--cysteine ligase catalytic subunit Glutamate--cysteine ligase regulatory subunit Glutathione S-transferase A1 Glutathione S-transferase A3 Heme oxygenase 1 Histone acetyltransferase p300 NAD(P)H dehydrogenase [quinone] 1 Nuclear factor erythroid 2-related factor 2 Peroxiredoxin-1 Sulfiredoxin-1 Thioredoxin reductase 1, cytoplasmic Thioredoxin Transcription factor MafK Transcription regulator protein BACH1	O14867 O60675 P08263 P08294 P09601 P10599 P15559 P18848 P48506 P48507 Q06830 Q09472 Q16236 Q16772 Q16881 Q92793 Q9BYN0 Q9UPY5	ATF4 BACH1 C20orf139 CBP CREB2 CREBBP DIA4 EP300 GCLC GCLM GLCL GLCLC GLCLR GRIM12 GSTA1 GSTA3 HMOX1 HO HO1 KDRF MAFK NFE2L2 NMOR1 NQO1 NRF2 P300 PAGA PAGB PRDX1 SLC7A11 SOD3 SRX SRX1 SRXN1 TDPX2 TRDX TRX TRX1 TXN TXNRD1 TXREB	Homo sapiens (human)
NFE2L2 regulating inflammation associated genes	C-C motif chemokine 2 CREB-binding protein Histone acetyltransferase p300 Nuclear factor erythroid 2-related factor 2 Transcription factor MafK	O60675 P13500 Q09472 Q16236 Q92793	CBP CCL2 CREBBP EP300 MAFK MCP1 NFE2L2 NRF2 P300 SCYA2	Homo sapiens (human)
NFE2L2 regulating tumorigenic genes	Amphiregulin Apoptosis regulator Bcl-2 Bcl-2-like protein 1 CREB-binding protein Histone acetyltransferase p300 Neurogenic locus notch homolog protein 1 Nuclear factor erythroid 2-related factor 2 Platelet-derived growth factor subunit A Pro-epidermal growth factor Transcription factor MafK Transcription factor Sp1	O60675 P01133 P04085 P08047 P10415 P15514 P46531 Q07817 Q09472 Q16236 Q92793	AREG AREGB BCL2 BCL2L BCL2L1 BCLX CBP CREBBP EGF EP300 MAFK NFE2L2 NOTCH1 NRF2 P300 PDGF1 PDGFA SDGF SP1 TAN1 TSFP1	Homo sapiens (human)
NFG and proNGF binds to p75NTR	Beta-nerve growth factor Sortilin-related VPS10 domain containing receptor 3 Tumor necrosis factor receptor superfamily member 16	P01138 P08138 Q17R88	NGF NGFB NGFR SORCS3 TNFRSF16	Homo sapiens (human)
NGF processing	Beta-nerve growth factor Furin Proprotein convertase subtilisin/kexin type 5 Proprotein convertase subtilisin/kexin type 6	P01138 P09958 P29122 Q92824	FUR FURIN NGF NGFB PACE PACE4 PC5 PC6 PCSK3 PCSK5 PCSK6	Homo sapiens (human)
NGF-independant TRKA activation	Adenosine receptor A2a BDNF/NT-3 growth factors receptor High affinity nerve growth factor receptor Pituitary adenylate cyclase-activating polypeptide type I receptor Pituitary adenylate cyclase-activating polypeptide	P04629 P18509 P29274 P41586 Q16620	ADCYAP1 ADCYAP1R1 ADORA2 ADORA2A MTC NTRK1 NTRK2 TRK TRKA TRKB	Homo sapiens (human)
NGF-stimulated transcription	Achaete-scute homolog 1 Activity-regulated cytoskeleton-associated protein Chromodomain-helicase-DNA-binding protein 4 Cyclic AMP-dependent transcription factor ATF-1 Cyclic AMP-dependent transcription factor ATF-2 Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 2 Cyclin-dependent kinase 5 DNA-binding protein inhibitor ID-1 DNA-binding protein inhibitor ID-2 DNA-binding protein inhibitor ID-3 DNA-binding protein inhibitor ID-4 Dynamin-2 E3 SUMO-protein ligase EGR2 ETS domain-containing protein Elk-1 Early growth response protein 1 Early growth response protein 3 Early growth response protein 4 Endophilin-A3 Fos-related antigen 1 GTP-binding protein RAD Histone acetyltransferase p300 Myocyte-specific enhancer factor 2D NGFI-A-binding protein 1 NGFI-A-binding protein 2 Neurosecretory protein VGF Protein FosB Protein c-Fos Protein lyl-1 RE1-silencing transcription factor Serine/threonine-protein kinase Sgk1 Serum response factor Tissue factor Transcription factor 12 Transcription factor JunB Transcription factor JunD Tribbles homolog 1 Tryptophan 5-hydroxylase 1	O00141 O15240 P01100 P11161 P11831 P12980 P13726 P15336 P15407 P17275 P17535 P17752 P18146 P18846 P19419 P41134 P47928 P50553 P50570 P53539 P55042 Q00535 Q02363 Q02535 Q05215 Q06889 Q09472 Q13127 Q13319 Q13506 Q14814 Q14839 Q15078 Q15742 Q7LC44 Q96RU8 Q99081 Q99963	1R21 ARC ASCL1 ASH1 ATF1 ATF2 BHLHA18 BHLHA46 BHLHB20 BHLHB24 BHLHB25 BHLHB26 BHLHB27 C8FW CDK5 CDK5R CDK5R1 CDK5R2 CDKN5 CHD4 CNSA3 CREB2 CREBP1 DNM2 DYN2 EGR1 EGR2 EGR3 EGR4 ELK1 EP300 F3 FOS FOSB FOSL1 FRA1 G0S3 G0S7 GIG2 HASH1 HEB HEIR1 HTF4 ID ID1 ID2 ID3 ID4 JUNB JUND KIAA0278 KROX20 KROX24 LYL1 MADER MEF2D NAB1 NAB2 NCK5A NCK5AI NRSF P300 PILOT PSSALRE RAD REST RRAD SGK SGK1 SH3D2C SH3GL3 SRF TCF12 TPH TPH1 TPRH TRB1 TRIB1 TRPH VGF XBR ZNF225	Homo sapiens (human)
NIK-->noncanonical NF-kB signaling	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin-1 F-box/WD repeat-containing protein 11 F-box/WD repeat-containing protein 1A Inhibitor of nuclear factor kappa-B kinase subunit alpha Mitogen-activated protein kinase kinase kinase 14 NEDD8-activating enzyme E1 catalytic subunit NEDD8-conjugating enzyme Ubc12 Nuclear factor NF-kappa-B p100 subunit Polyubiquitin-B Polyubiquitin-C Proteasomal ubiquitin receptor ADRM1 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 S-phase kinase-associated protein 1 Transcription factor RelB Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00231 O00232 O00487 O14818 O15111 O43242 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28066 P28070 P28072 P28074 P35998 P43686 P48556 P49720 P49721 P51665 P60896 P60900 P61081 P62191 P62195 P62333 P62979 P62987 P63208 Q00653 Q01201 Q13200 Q13616 Q15008 Q16186 Q8TBC4 Q99436 Q99460 Q99558 Q9UKB1 Q9UNM6 Q9Y297	ADRM1 BTRC BTRCP BTRCP2 C7orf76 CHUK CUL1 DSS1 EMC19 FBW1A FBW1B FBXW11 FBXW1A FBXW1B GP110 HC2 HC3 HC8 HC9 HSPC IKKA KIAA0107 KIAA0696 LMPX LMPY LYT10 MAP3K14 MB1 MIP224 MOV34L MSS1 NFKB2 NIK NU OCP2 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RELB RPS27A SEM1 SHFDG1 SHFM1 SKP1 SKP1A SUG1 SUG2 TBP1 TBP7 TCEB1L TCF16 TRAP2 UBA3 UBA52 UBA80 UBB UBC UBC12 UBCEP1 UBCEP2 UBE1C UBE2M X Y Z	Homo sapiens (human)
NOD1/2 Signaling Pathway	Angio-associated migratory cell protein Baculoviral IAP repeat-containing protein 2 Baculoviral IAP repeat-containing protein 3 Caspase recruitment domain-containing protein 9 Caspase-1 Caspase-2 Caspase-4 Caspase-8 Caspase-9 Dual specificity mitogen-activated protein kinase kinase 6 E3 ubiquitin-protein ligase Itchy homolog Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase-like 2 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 13 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Nucleoprotein Nucleotide-binding oligomerization domain-containing protein 1 Nucleotide-binding oligomerization domain-containing protein 2 Receptor-interacting serine/threonine-protein kinase 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Tumor necrosis factor alpha-induced protein 3 Ubiquitin carboxyl-terminal hydrolase CYLD Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	O14920 O15111 O15264 O43187 O43318 O43353 P0DTC9 P21580 P29466 P42575 P49662 P51617 P52564 P53778 P55211 P61088 Q13404 Q13489 Q13490 Q13685 Q14790 Q15750 Q15759 Q16539 Q8N5C8 Q96J02 Q9H257 Q9HC29 Q9NQC7 Q9NYJ8 Q9Y239 Q9Y4K3 Q9Y6K9	AAMP API1 API2 BIRC2 BIRC3 BLU CARD15 CARD4 CARD9 CARDIAK CASP1 CASP2 CASP4 CASP8 CASP9 CHUK CROC1 CSBP CSBP1 CSBP2 CSPB1 CYLD CYLD1 ERK6 FIP3 ICH1 ICH2 IKBKB IKBKG IKKA IKKB IL1BC IL1BCE IRAK IRAK1 IRAK2 ITCH KIAA0733 KIAA0849 MAP2K6 MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 MAPK11 MAPK12 MAPK13 MAPK14 MCH5 MCH6 MEK6 MIHB MIHC MKK6 MXI2 N NEDD2 NEMO NOD1 NOD2 OTUD7C PRKM11 PRKM13 PRKMK6 RICK RIP2 RIPK2 RNF48 RNF49 RNF85 SAPK2 SAPK2A SAPK2B SAPK3 SAPK4 SKK3 TAB1 TAB2 TAB3 TAK1 TCF16 TNFAIP3 TRAF6 UBE2N UBE2V UBE2V1 UEV1	Homo sapiens (human)
NOSIP mediated eNOS trafficking	Nitric oxide synthase 3 Nitric oxide synthase-interacting protein	P29474 Q9Y314	NOS3 NOSIP	Homo sapiens (human)
NOSTRIN mediated eNOS trafficking	Actin nucleation-promoting factor WASL Caveolin-1 Dynamin-2 Nitric oxide synthase 3 Nostrin	O00401 P29474 P50570 Q03135 Q8IVI9	CAV CAV1 DNM2 DYN2 NOS3 NOSTRIN WASL	Homo sapiens (human)
NOTCH1 Intracellular Domain Regulates Transcription	CREB-binding protein Cullin-1 Cyclin-C Cyclin-dependent kinase 8 E3 ubiquitin-protein ligase RBX1 F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 Hairy/enhancer-of-split related with YRPW motif protein 1 Hairy/enhancer-of-split related with YRPW motif protein 2 Hairy/enhancer-of-split related with YRPW motif-like protein Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase p300 Histone deacetylase 11 Histone deacetylase 1 Histone deacetylase 2 Histone deacetylase 3 Histone deacetylase 4 Histone deacetylase 5 Histone deacetylase 6 Histone deacetylase 7 Histone deacetylase 8 Histone deacetylase 9 Hypoxia-inducible factor 1-alpha Mastermind-like domain-containing protein 1 Mastermind-like protein 1 Mastermind-like protein 2 Mastermind-like protein 3 Myc proto-oncogene protein Neurobeachin Neurogenic locus notch homolog protein 1 Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Polyamine deacetylase HDAC10 Polyubiquitin-B Polyubiquitin-C Recombining binding protein suppressor of hairless S-phase kinase-associated protein 1 SNW domain-containing protein 1 Transcription factor HES-1 Transcription factor HES-5 Transducin-like enhancer protein 1 Transducin-like enhancer protein 2 Transducin-like enhancer protein 4 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O15379 O60907 O75376 P01106 P0CG47 P0CG48 P24863 P46531 P49336 P56524 P62877 P62979 P62987 P63208 Q04724 Q04725 Q04727 Q06330 Q09472 Q13495 Q13547 Q13573 Q13616 Q14469 Q16665 Q5TA89 Q8IZL2 Q8NFP9 Q8WUI4 Q92585 Q92769 Q92793 Q92830 Q92831 Q969S8 Q96DB2 Q96JK9 Q9BY41 Q9BZK7 Q9NQ87 Q9UBN7 Q9UBP5 Q9UKV0 Q9UQL6 Q9Y5J3 Q9Y618	BCL8B BHLHB31 BHLHB32 BHLHB33 BHLHB38 BHLHB39 BHLHE39 BHLHE78 CBP CCNC CDK8 CG1 CHF1 CHF2 CREBBP CTG26 CUL1 CXorf6 EMC19 EP300 GCN5 GCN5L2 GRG4 GRL HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC7A HDAC7B HDAC8 HDAC9 HDACL1 HDRP HERP HERP1 HERP2 HES1 HES5 HESR1 HEY1 HEY2 HEYL HIF1A HL HRT1 HRT2 HRT3 HRY IGKJRB IGKJRB1 IRA1 KAT2A KAT2B KIAA0200 KIAA0288 KIAA0600 KIAA0744 KIAA0901 KIAA1047 KIAA1261 KIAA1544 KIAA1816 KIAA1819 LYST2 MAML1 MAML2 MAML3 MAMLD1 MITR MOP1 MYC NBEA NCOR1 NCOR2 NOTCH1 OCP2 P300 PASD8 PCAF RBPJ RBPJK RBPSUH RBX1 RNF75 ROC1 RPD3L1 RPS27A SKIIP SKIP SKP1 SKP1A SNW1 TAN1 TBL1 TBL1X TBL1XR1 TBLR1 TCEB1L TLE1 TLE2 TLE4 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
NOTCH2 Activation and Transmission of Signal to the Nucleus	Contactin-1 Delta-like protein 1 Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 E3 ubiquitin-protein ligase MIB1 E3 ubiquitin-protein ligase MIB2 E3 ubiquitin-protein ligase NEURL1 E3 ubiquitin-protein ligase NEURL1B Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Midkine Neurogenic locus notch homolog protein 2 Nicastrin Notch homolog 2 N-terminal-like protein A Notch homolog 2 N-terminal-like protein B Notch homolog 2 N-terminal-like protein C Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Protein jagged-1 Protein jagged-2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A8MQ27 O00548 O14672 O76050 P0CG47 P0CG48 P0DPK3 P0DPK4 P21741 P49768 P49810 P62979 P62987 P78504 Q04721 Q12860 Q7Z3S9 Q86YT6 Q8WW43 Q92542 Q96AX9 Q96BI3 Q9NR61 Q9NZ42 Q9Y219	AD3 AD4 ADAM10 APH1A APH1B CNTN1 DIP1 DLL1 DLL4 JAG1 JAG2 JAGL1 KIAA0253 KIAA1323 KUZ MADM MDK MIB1 MIB2 MK1 N2N NCSTN NEGF2 NEURL NEURL1 NEURL1A NEURL1B NEURL3 NOTCH2 NOTCH2NL NOTCH2NLA NOTCH2NLB NOTCH2NLC PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RNF67 RPS27A SKD STM2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 ZZANK1 ZZANK2	Homo sapiens (human)
NOTCH2 intracellular domain regulates transcription	Granzyme B Histone acetyltransferase p300 Low affinity immunoglobulin epsilon Fc receptor Mastermind-like domain-containing protein 1 Mastermind-like protein 1 Mastermind-like protein 2 Mastermind-like protein 3 Neurogenic locus notch homolog protein 2 Recombining binding protein suppressor of hairless Transcription factor HES-1 Transcription factor HES-5	P06734 P10144 Q04721 Q06330 Q09472 Q13495 Q14469 Q5TA89 Q8IZL2 Q92585 Q96JK9	BHLHB38 BHLHB39 CD23A CG1 CGL1 CLEC4J CSPB CTLA1 CXorf6 EP300 FCE2 FCER2 GRB GZMB HES1 HES5 HL HRY IGEBF IGKJRB IGKJRB1 KIAA0200 KIAA1816 KIAA1819 MAML1 MAML2 MAML3 MAMLD1 NOTCH2 P300 RBPJ RBPJK RBPSUH	Homo sapiens (human)
NOTCH3 Activation and Transmission of Signal to the Nucleus	Delta-like protein 1 Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 E3 ubiquitin-protein ligase MIB1 E3 ubiquitin-protein ligase MIB2 E3 ubiquitin-protein ligase NEURL1 E3 ubiquitin-protein ligase NEURL1B Epidermal growth factor receptor Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 NEDD4-like E3 ubiquitin-protein ligase WWP2 Neurogenic locus notch homolog protein 3 Nicastrin Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Pro-epidermal growth factor Protein jagged-1 Protein jagged-2 Transforming acidic coiled-coil-containing protein 3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A8MQ27 O00308 O00548 O14672 O76050 P00533 P01133 P0CG47 P0CG48 P49768 P49810 P62979 P62987 P78504 Q86YT6 Q8WW43 Q92542 Q96AX9 Q96BI3 Q9NR61 Q9NZ42 Q9UM47 Q9Y219 Q9Y6A5	AD3 AD4 ADAM10 APH1A APH1B DIP1 DLL1 DLL4 EGF EGFR ERBB ERBB1 ERIC1 HER1 JAG1 JAG2 JAGL1 KIAA0253 KIAA1323 KUZ MADM MIB1 MIB2 NCSTN NEURL NEURL1 NEURL1A NEURL1B NEURL3 NOTCH3 PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RNF67 RPS27A SKD STM2 TACC3 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WWP2 ZZANK1 ZZANK2	Homo sapiens (human)
NOTCH3 Intracellular Domain Regulates Transcription	CREB-binding protein Disks large-associated protein 5 Fatty acid-binding protein, brain Hairy/enhancer-of-split related with YRPW motif protein 1 Hairy/enhancer-of-split related with YRPW motif protein 2 Hairy/enhancer-of-split related with YRPW motif-like protein Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase p300 Mastermind-like domain-containing protein 1 Mastermind-like protein 1 Mastermind-like protein 2 Mastermind-like protein 3 Neurogenic locus notch homolog protein 1 Neurogenic locus notch homolog protein 3 Plexin-D1 Pre T-cell antigen receptor alpha Pre-B-cell leukemia transcription factor 1 Protein KIBRA Recombining binding protein suppressor of hairless SNW domain-containing protein 1 Signal transducer and activator of transcription 1-alpha/beta Transcription factor HES-1 Transcription factor HES-5	O15540 P40424 P42224 P46531 Q06330 Q09472 Q13495 Q13573 Q14469 Q15398 Q5TA89 Q6ISU1 Q8IX03 Q8IZL2 Q92585 Q92793 Q92830 Q92831 Q96JK9 Q9NQ87 Q9UBP5 Q9UM47 Q9Y4D7 Q9Y5J3	BHLHB31 BHLHB32 BHLHB33 BHLHB38 BHLHB39 BLBP CBP CG1 CHF1 CHF2 CREBBP CXorf6 DLG7 DLGAP5 EP300 FABP7 FABPB GCN5 GCN5L2 GRL HERP HERP1 HERP2 HES1 HES5 HESR1 HEY1 HEY2 HEYL HL HRT1 HRT2 HRT3 HRY IGKJRB IGKJRB1 KAT2A KAT2B KIAA0008 KIAA0200 KIAA0620 KIAA0869 KIAA1816 KIAA1819 KIBRA MAML1 MAML2 MAML3 MAMLD1 MRG NOTCH1 NOTCH3 P300 PBX1 PCAF PLXND1 PRL PTCRA RBPJ RBPJK RBPSUH SKIIP SKIP SNW1 STAT1 TAN1 WWC1	Homo sapiens (human)
NOTCH4 Activation and Transmission of Signal to the Nucleus	14-3-3 protein zeta/delta Delta-like protein 4 Disintegrin and metalloproteinase domain-containing protein 10 Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Neurogenic locus notch homolog protein 4 Nicastrin Presenilin-1 Presenilin-2 Protein jagged-1	O14672 P49768 P49810 P63104 P78504 Q8WW43 Q92542 Q96BI3 Q99466 Q9NR61 Q9NZ42	AD3 AD4 ADAM10 APH1A APH1B DLL4 INT3 JAG1 JAGL1 KIAA0253 KUZ MADM NCSTN NOTCH4 PEN2 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 STM2 YWHAZ	Homo sapiens (human)
NOTCH4 Intracellular Domain Regulates Transcription	Actin, aortic smooth muscle CREB-binding protein Hairy/enhancer-of-split related with YRPW motif protein 1 Hairy/enhancer-of-split related with YRPW motif protein 2 Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase p300 Mastermind-like domain-containing protein 1 Mastermind-like protein 1 Mastermind-like protein 2 Mastermind-like protein 3 Mothers against decapentaplegic homolog 3 Neurogenic locus notch homolog protein 1 Neurogenic locus notch homolog protein 2 Neurogenic locus notch homolog protein 4 Recombining binding protein suppressor of hairless SNW domain-containing protein 1 Transcription factor HES-1 Transcription factor HES-5 Vascular endothelial growth factor receptor 3	P35916 P46531 P62736 P84022 Q04721 Q06330 Q09472 Q13495 Q13573 Q14469 Q5TA89 Q8IZL2 Q92585 Q92793 Q92830 Q92831 Q96JK9 Q99466 Q9UBP5 Q9Y5J3	ACTA2 ACTSA ACTVS BHLHB31 BHLHB32 BHLHB38 BHLHB39 CBP CG1 CHF1 CHF2 CREBBP CXorf6 EP300 FLT4 GCN5 GCN5L2 GRL HERP HERP1 HERP2 HES1 HES5 HESR1 HEY1 HEY2 HL HRT1 HRT2 HRY IGKJRB IGKJRB1 INT3 KAT2A KAT2B KIAA0200 KIAA1816 KIAA1819 MADH3 MAML1 MAML2 MAML3 MAMLD1 NOTCH1 NOTCH2 NOTCH4 P300 PCAF RBPJ RBPJK RBPSUH SKIIP SKIP SMAD3 SNW1 TAN1 VEGFR3	Homo sapiens (human)
NPAS4 regulates expression of target genes	Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Basic helix-loop-helix ARNT-like protein 1 Brain-derived neurotrophic factor CREB-binding protein Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 E3 ubiquitin-protein ligase Mdm2 Exportin-1 GTP-binding protein GEM IQ motif and SEC7 domain-containing protein 3 Insulin Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Neuronal PAS domain-containing protein 4 Nicotinamide phosphoribosyltransferase Protein c-Fos Proto-oncogene tyrosine-protein kinase receptor Ret RNA binding protein fox-1 homolog 3 Serine/threonine-protein kinase PLK2 Synaptotagmin-10	A6NFN3 O00327 O14980 P01100 P01308 P07949 P23560 P27361 P27540 P28482 P43490 P55040 Q00535 Q00987 Q15078 Q6XYQ8 Q8IUM7 Q92793 Q9HBZ2 Q9NYY3 Q9UPP2	ARNT ARNT2 ARNTL BDNF BHLHE1 BHLHE2 BHLHE5 BHLHE79 BMAL1 CBP CDHF12 CDHR16 CDK5 CDK5R CDK5R1 CDKN5 CREBBP CRM1 ERK1 ERK2 FOS G0S7 GEM INS IQSEC3 KIAA0307 KIAA1110 KIR MAPK1 MAPK3 MDM2 MOP3 NAMPT NCK5A NPAS4 NXF PASD10 PASD3 PBEF PBEF1 PLK2 PRKM1 PRKM2 PRKM3 PSSALRE PTC RBFOX3 RET SNK SYT10 XPO1	Homo sapiens (human)
NR1D1 (REV-ERBA) represses gene expression	Histone deacetylase 3 Nuclear receptor corepressor 1 Nuclear receptor subfamily 1 group D member 1	O15379 O75376 P20393	EAR1 HDAC3 HREV KIAA1047 NCOR1 NR1D1 THRAL	Homo sapiens (human)
NRAGE signals death through JNK	A-kinase anchor protein 13 Active breakpoint cluster region-related protein Bcl-2-like protein 11 Bcl2-associated agonist of cell death Beta-nerve growth factor Ephexin-1 FYVE, RhoGEF and PH domain-containing protein 1 FYVE, RhoGEF and PH domain-containing protein 2 FYVE, RhoGEF and PH domain-containing protein 3 FYVE, RhoGEF and PH domain-containing protein 4 Guanine nucleotide exchange factor DBS Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Guanine nucleotide-binding protein subunit alpha-13 Intersectin-1 Kalirin Melanoma-associated antigen D1 Mitogen-activated protein kinase 8 Neuroepithelial cell-transforming gene 1 protein Obscurin Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Pleckstrin homology domain-containing family G member 2 Pleckstrin homology domain-containing family G member 5 Protein AATF Protein ECT2 Proto-oncogene DBL Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Ras-specific guanine nucleotide-releasing factor 2 Rho guanine nucleotide exchange factor 10-like protein Rho guanine nucleotide exchange factor 10 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 12 Rho guanine nucleotide exchange factor 15 Rho guanine nucleotide exchange factor 16 Rho guanine nucleotide exchange factor 17 Rho guanine nucleotide exchange factor 18 Rho guanine nucleotide exchange factor 19 Rho guanine nucleotide exchange factor 1 Rho guanine nucleotide exchange factor 26 Rho guanine nucleotide exchange factor 2 Rho guanine nucleotide exchange factor 33 Rho guanine nucleotide exchange factor 35 Rho guanine nucleotide exchange factor 37 Rho guanine nucleotide exchange factor 38 Rho guanine nucleotide exchange factor 39 Rho guanine nucleotide exchange factor 3 Rho guanine nucleotide exchange factor 40 Rho guanine nucleotide exchange factor 4 Rho guanine nucleotide exchange factor 5 Rho guanine nucleotide exchange factor 6 Rho guanine nucleotide exchange factor 7 Rho guanine nucleotide exchange factor 9 Rho guanine nucleotide exchange factor TIAM1 Rho guanine nucleotide exchange factor TIAM2 Son of sevenless homolog 1 Son of sevenless homolog 2 Triple functional domain protein Tumor necrosis factor receptor superfamily member 16	A1IGU5 A5YM69 A8MVX0 O14827 O15013 O15068 O15085 O43307 O43521 O60229 O75962 O94827 O94989 P01138 P08138 P10911 P15498 P45983 P52735 P63000 P98174 Q07889 Q07890 Q12774 Q12802 Q12979 Q13009 Q14155 Q14344 Q15052 Q15811 Q5JSP0 Q5VST9 Q5VV41 Q6ZSZ5 Q7Z628 Q7Z6J4 Q8IVF5 Q8IW93 Q8N4T4 Q8N5V2 Q8TCU6 Q8TER5 Q92888 Q92934 Q92974 Q96DR7 Q96M96 Q96PE2 Q9H7P9 Q9H8V3 Q9HCE6 Q9NR80 Q9NR81 Q9NXL2 Q9NY61 Q9NZN5 Q9UKW4 Q9Y5V3	AATF ABR AKAP13 ARHDH9 ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF26 ARHGEF3 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF5L ARHGEF6 ARHGEF7 ARHGEF8 ARHGEF9 BAD BBC6 BCL2L11 BCL2L8 BIM BRX C9orf100 CHE1 COOL1 COOL2 DBL DED DUET DUO ECT2 EPHEXIN4 FGD1 FGD2 FGD3 FGD4 FGDY FRABP GNA13 GRF2 GRINCHGEF HAPIP HT31 ITSN ITSN1 JNK1 KALRN KIAA0006 KIAA0142 KIAA0294 KIAA0337 KIAA0362 KIAA0380 KIAA0382 KIAA0424 KIAA0521 KIAA0651 KIAA0720 KIAA0915 KIAA1112 KIAA1415 KIAA1556 KIAA1626 KIAA1639 KIAA2016 LARG LBC LFP40 MAGED1 MAPK8 MCF2 MCF2L NBR NET1 NGEF NGF NGFB NGFR NRAGE OBSCN OST P85SPR PAK3BP PIXA PIXB PLEKHG2 PLEKHG5 PREX1 PRKM8 RAC1 RASGRF2 SAPK1 SAPK1C SGEF SH3D1A SOLO SOS1 SOS2 STEF TC25 TEM4 TIAM1 TIAM2 TIM TNFRSF16 TRAD TRIO VAV VAV1 VAV2 VAV3 ZFYVE3 ZFYVE4 ZFYVE5 ZFYVE6	Homo sapiens (human)
NRIF signals cell death from the nucleus	Beta-nerve growth factor Centromere protein R Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Mitogen-activated protein kinase 8 Nicastrin Polyubiquitin-B Polyubiquitin-C Presenilin-1 Presenilin-2 Sequestosome-1 TNF receptor-associated factor 6 Tumor necrosis factor receptor superfamily member 16 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P01138 P08138 P0CG47 P0CG48 P45983 P49768 P49810 P62979 P62987 Q13352 Q13501 Q8WW43 Q92542 Q96BI3 Q9NZ42 Q9Y4K3	AD3 AD4 APH1A APH1B CENPR ITGB3BP JNK1 KIAA0253 MAPK8 NCSTN NGF NGFB NGFR NRIF3 ORCA OSIL PEN2 PRKM8 PS1 PS2 PSEN1 PSEN2 PSENEN PSF PSFL PSNL1 PSNL2 RNF85 RPS27A SAPK1 SAPK1C SQSTM1 STM2 TNFRSF16 TRAF6 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)

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