GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **1276 - 1300** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Downregulation of SMAD2/3:SMAD4 transcriptional activity	E3 ubiquitin-protein ligase Arkadia E3 ubiquitin-protein ligase NEDD4-like E3 ubiquitin-protein ligase SMURF2 E3 ubiquitin-protein ligase TRIM33 Histone deacetylase 1 Homeobox protein TGIF1 Homeobox protein TGIF2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Mothers against decapentaplegic homolog 7 Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Poly [ADP-ribose] polymerase 1 Polyubiquitin-B Polyubiquitin-C Protein ATP1B4 Protein phosphatase 1A SNW domain-containing protein 1 Ski oncogene Ski-like protein Ubiquitin carboxyl-terminal hydrolase 9X Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein WW domain-containing transcription regulator protein 1	O15105 O75376 P09874 P0CG47 P0CG48 P12755 P12757 P27361 P28482 P35813 P51668 P61077 P62979 P62987 P84022 Q13485 Q13547 Q13573 Q15583 Q15796 Q6ZNA4 Q93008 Q96PU5 Q9GZN2 Q9GZV5 Q9HAU4 Q9UN42 Q9UPN9 Q9Y618	ADPRT ATP1B4 CTG26 DFFRX DPC4 ERK1 ERK2 FAM HDAC1 KIAA0439 KIAA1047 KIAA1113 MADH2 MADH3 MADH4 MADH7 MADH8 MADR2 MAPK1 MAPK3 NCOR1 NCOR2 NEDD4L NEDL3 PARP1 PPM1A PPOL PPPM1A PRKM1 PRKM2 PRKM3 RFG7 RNF111 RPD3L1 RPS27A SFT SKI SKIIP SKIL SKIP SMAD2 SMAD3 SMAD4 SMAD7 SMURF2 SNO SNW1 TAZ TGIF TGIF1 TGIF2 TIF1G TRIM33 UBA52 UBA80 UBB UBC UBC5A UBC5C UBCEP1 UBCEP2 UBCH5 UBCH5A UBCH5C UBE2D1 UBE2D3 USP9 USP9X WWTR1	Homo sapiens (human)
ERBB2 Regulates Cell Motility	Epidermal growth factor receptor Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein MEMO1 Protein diaphanous homolog 1 Receptor tyrosine-protein kinase erbB-2 Transforming protein RhoA	O14511 O14944 O60610 P00533 P01133 P04626 P35070 P56975 P61586 Q02297 Q8WWG1 Q99075 Q9Y316	ARH12 ARHA BTC C2orf4 DIAP1 DIAPH1 DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GGF HBEGF HEGFL HER1 HER2 HGL HRGA MEMO MEMO1 MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NS5ATP7 NTAK RHO12 RHOA SMDF	Homo sapiens (human)
Amino acids regulate mTORC1	Cytosolic arginine sensor for mTORC1 subunit 1 Cytosolic arginine sensor for mTORC1 subunit 2 Folliculin-interacting protein 1 Folliculin-interacting protein 2 Folliculin GATOR1 complex protein DEPDC5 GATOR1 complex protein NPRL2 GATOR1 complex protein NPRL3 GATOR2 complex protein MIOS GATOR2 complex protein WDR24 GATOR2 complex protein WDR59 GTP-binding protein Rheb KICSTOR complex protein ITFG2 KICSTOR complex protein SZT2 KICSTOR complex protein kaptin KICSTOR subunit 2 Neutral amino acid transporter 9 Nucleoporin SEH1 Protein SEC13 homolog Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR S-adenosylmethionine sensor upstream of mTORC1 SH3 domain-binding protein 4 Serine/threonine-protein kinase mTOR Sestrin-1 Sestrin-2 Target of rapamycin complex subunit LST8 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 16 kDa proteolipid subunit c V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit B, kidney isoform V-type proton ATPase subunit C 1 V-type proton ATPase subunit C 2 V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit E 2 V-type proton ATPase subunit F V-type proton ATPase subunit G 1 V-type proton ATPase subunit G 2 V-type proton ATPase subunit G 3 V-type proton ATPase subunit H V-type proton ATPase subunit d 1 V-type proton ATPase subunit d 2 V-type proton ATPase subunit e 1 V-type proton ATPase subunit e 2	A6NHX0 O15342 O43504 O75140 O75348 O95670 P15313 P21281 P21283 P27449 P36543 P38606 P42345 P55735 P58004 P61421 Q0VGL1 Q12980 Q13488 Q15382 Q16864 Q1RMZ1 Q5T011 Q5VZM2 Q6IAA8 Q6PJI9 Q7L523 Q8N122 Q8N8Y2 Q8NBW4 Q8NEY4 Q8NFG4 Q8NHE4 Q8TF40 Q8WTW4 Q8WTX7 Q969R8 Q96A05 Q96EE3 Q96LB4 Q96MD2 Q96S15 Q99437 Q9BVC4 Q9HB90 Q9NQL2 Q9NXC5 Q9P0V3 Q9P278 Q9UHA4 Q9UI12 Q9Y2Q5 Q9Y5K8 Q9Y664 Q9Y6P5	ATP6A1 ATP6B1 ATP6B2 ATP6C ATP6D ATP6E ATP6E1 ATP6E2 ATP6EL2 ATP6F ATP6G ATP6G1 ATP6G2 ATP6G3 ATP6H ATP6J ATP6L ATP6M ATP6N1C ATP6S14 ATP6V0A3 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E ATP6V0E1 ATP6V0E2 ATP6V0E2L ATP6V1A ATP6V1A1 ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1EL2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATPL BHD BMT2 BOG25 C11orf59 C12orf66 C16orf21 C16orf35 C1orf84 C7orf32 C7orf59 C7orf60 CASTOR1 CASTOR2 CGTHBA D3S1231E DEPDC5 EHB10 FLCN FNIP1 FNIP2 FNIPL FRAP FRAP1 FRAP2 GATSL1 GATSL2 GATSL3 GBL HBXIP Hi95 ITFG2 KIAA0467 KIAA0645 KIAA1303 KIAA1450 KIAA1923 KIAA1961 KICS2 KPTN LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MAPO1 MARE MIOS MLST8 MTOR NG38 NPRL2 NPRL3 PA26 PDRO RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD SAMTOR SEC13 SEC13A SEC13L SEC13L1 SEC13R SEH1 SEH1L SESN1 SESN2 SEST1 SEST2 SH3BP4 SLC38A9 SZT2 TCIRG1 TTP TUSC4 URLC11 VATB VATC VATD VATF VPATPD VPP2 VPP3 WDR24 WDR59 XIP	Homo sapiens (human)
RNA Polymerase I Transcription Initiation	CDK-activating kinase assembly factor MAT1 Chromodomain-helicase-DNA-binding protein 3 Chromodomain-helicase-DNA-binding protein 4 Cyclin-H Cyclin-dependent kinase 7 DNA excision repair protein ERCC-6 DNA-directed RNA polymerase I subunit RPA12 DNA-directed RNA polymerase I subunit RPA1 DNA-directed RNA polymerase I subunit RPA2 DNA-directed RNA polymerase I subunit RPA34 DNA-directed RNA polymerase I subunit RPA43 DNA-directed RNA polymerase I subunit RPA49 DNA-directed RNA polymerases I and III subunit RPAC1 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone deacetylase 1 Histone deacetylase 2 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EHMT2 Metastasis-associated protein MTA1 Metastasis-associated protein MTA2 Metastasis-associated protein MTA3 Methyl-CpG-binding domain protein 3 Nucleolar transcription factor 1 Protein POLR1D, isoform 2 RNA polymerase I-specific transcription initiation factor RRN3 TATA box-binding protein-associated factor RNA polymerase I subunit A TATA box-binding protein-associated factor RNA polymerase I subunit B TATA box-binding protein-associated factor RNA polymerase I subunit C TATA box-binding protein-associated factor RNA polymerase I subunit D TATA-box-binding protein Transcription termination factor 1 Transcriptional repressor p66-alpha Transcriptional repressor p66-beta	O15160 O15446 O94776 O95602 O95983 P0DPB5 P17480 P18074 P19388 P19447 P20226 P32780 P50613 P51946 P51948 P52434 P53803 P61218 P62875 Q03468 Q09028 Q12873 Q13330 Q13547 Q13888 Q13889 Q14839 Q15361 Q15572 Q15573 Q16576 Q3B726 Q53T94 Q6ZYL4 Q86YP4 Q8WXI9 Q92759 Q92769 Q92830 Q92831 Q96KQ7 Q9BTC8 Q9GZS1 Q9H5J8 Q9H9Y6 Q9NYV6 Q9P1U0	ASE1 BAT8 BTF2 BTF2P44 C6orf175 C6orf30 CAK CAK1 CAP35 CAST CCNH CD3EAP CDK7 CDKN7 CHD3 CHD4 CSB EHMT2 ERCC2 ERCC3 ERCC6 G9A GATAD2A GATAD2B GCN5 GCN5L2 GTF2D1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 HDAC1 HDAC2 JOSD3 KAT2A KAT2B KIAA1150 KIAA1266 KMT1C MAT1 MBD3 MNAT1 MO15 MTA1 MTA1L1 MTA2 MTA3 NG36 PAF49 PAF53 PCAF PID POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L POLRF PRAF1 RBAP46 RBAP48 RBBP4 RBBP7 RNF66 RPA12 RPD3L1 RRN3 STK1 TAF1A TAF1B TAF1C TAF1D TBP TF2D TFIID TIFIA TTDA TTF1 TWISTNB UBF UBF1 UBTF XPB XPBC XPD XPDC ZNRD1	Homo sapiens (human)
SHC1 events in ERBB4 signaling	GTPase HRas GTPase NRas Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor SHC-transforming protein 1 Son of sevenless homolog 1	O14511 O14944 P01111 P01112 P29353 P35070 P56975 Q02297 Q07889 Q8WWG1 Q99075	BTC DTR DTS EREG GGF HBEGF HEGFL HGL HRAS HRAS1 HRGA NDF NRAS NRG1 NRG2 NRG3 NRG4 NTAK SHC SHC1 SHCA SMDF SOS1	Homo sapiens (human)
Protein hydroxylation	2-oxoglutarate and iron-dependent oxygenase JMJD4 Aspartyl/asparaginyl beta-hydroxylase Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 Bifunctional peptidase and arginyl-hydroxylase JMJD5 Coagulation factor IX Developmentally-regulated GTP-binding protein 1 Developmentally-regulated GTP-binding protein 2 Eukaryotic peptide chain release factor subunit 1 Large ribosomal subunit protein uL15 Large ribosomal subunit protein uL2 Prolyl 3-hydroxylase OGFOD1 RCC1 domain-containing protein 1 RWD domain-containing protein 1 Ribosomal oxygenase 1 Ribosomal oxygenase 2 Small ribosomal subunit protein eS6 Small ribosomal subunit protein uS12 Splicing factor U2AF 65 kDa subunit Zinc finger CCCH domain-containing protein 15	A6NED2 P00740 P0C870 P26368 P46776 P55039 P62266 P62495 P62753 P62917 Q12797 Q6NYC1 Q8IUF8 Q8N371 Q8N543 Q8WU90 Q9H446 Q9H6W3 Q9H9V9 Q9Y295	ASPH BAH C14orf169 DFRP1 DFRP2 DRG1 DRG2 ERF1 ETF1 F9 JMJD4 JMJD5 JMJD6 JMJD7 KDM8 KIAA0585 KIAA1612 LEREPO4 MAPJD MDIG MINA MINA53 NEDD3 NO52 NO66 OGFOD1 PSR PTDSR RCCD1 RF1 RIOX1 RIOX2 RPL27A RPL8 RPS23 RPS6 RWDD1 SUP45L1 TPA1 U2AF2 U2AF65 ZC3H15	Homo sapiens (human)
IRS-related events triggered by IGF1R	Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin receptor substrate 4 Insulin-like growth factor 1 receptor Insulin-like growth factor I Insulin-like growth factor II	O14654 P01344 P05019 P08069 P35568 Q9Y4H2	IBP1 IGF1 IGF1R IGF2 IRS1 IRS2 IRS4	Homo sapiens (human)
L1CAM interactions	Acyl-protein thioesterase 2 CD166 antigen Contactin-1 Contactin-2 Ephrin type-B receptor 2 Laminin subunit alpha-1 Laminin subunit beta-1 Laminin subunit gamma-1 Neural cell adhesion molecule L1 Neurocan core protein Neuromodulin Ran-binding protein 9 Signal transducer CD24	O14594 O95372 P07942 P11047 P17677 P25063 P25391 P29323 P32004 Q02246 Q12860 Q13740 Q96S59	ALCAM APT2 AXT CAML1 CD24 CD24A CNTN1 CNTN2 CSPG3 DRT EPHB2 EPHT3 EPTH3 ERK GAP43 HEK5 L1CAM LAMA LAMA1 LAMB1 LAMB2 LAMC1 LYPLA2 MEMD MIC5 NCAN NEUR RANBP9 RANBPM TAG1 TAX1 TYRO5	Homo sapiens (human)
SUMOylation of nuclear envelope proteins	Ran GTPase-activating protein 1 SUMO-conjugating enzyme UBC9 Small ubiquitin-related modifier 1	P46060 P63165 P63279	KIAA1835 RANGAP1 SD SMT3C SMT3H3 SUMO1 UBC9 UBCE9 UBE2I UBL1	Homo sapiens (human)
Activated NTRK2 signals through RAS	BDNF/NT-3 growth factors receptor Brain-derived neurotrophic factor GTPase HRas GTPase NRas Neurotrophin-4 Son of sevenless homolog 1	P01111 P01112 P23560 P34130 Q07889 Q16620	BDNF HRAS HRAS1 NRAS NTF4 NTF5 NTRK2 SOS1 TRKB	Homo sapiens (human)
MET activates PTPN11	GRB2-associated-binding protein 1 Hepatocyte growth factor receptor Hepatocyte growth factor Tyrosine-protein phosphatase non-receptor type 11	P08581 P14210 Q06124 Q13480	GAB1 HGF HPTA MET PTP2C PTPN11 SHPTP2	Homo sapiens (human)
Signaling by plasma membrane FGFR1 fusions	BAG family molecular chaperone regulator 4 Erlin-2 Fibroblast growth factor receptor 1	O94905 O95429 P11362	BAG4 BFGFR C8orf2 CEK ERLIN2 FGFBR FGFR1 FLG FLT2 HBGFR SODD SPFH2	Homo sapiens (human)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	DNA ligase 1 DNA mismatch repair protein Mlh1 DNA mismatch repair protein Msh2 DNA mismatch repair protein Msh3 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 Exonuclease 1 Mismatch repair endonuclease PMS2 Proliferating cell nuclear antigen Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit	P12004 P15927 P18858 P20585 P27694 P28340 P35244 P40692 P43246 P49005 P54278 Q15054 Q9HCU8 Q9UQ84	COCA2 DUC1 DUG EXO1 EXOI HEX1 KIAA0039 LIG1 MLH1 MSH2 MSH3 PCNA PMS2 PMSL2 POLD POLD1 POLD2 POLD3 POLD4 POLDS REPA1 REPA2 REPA3 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70	Homo sapiens (human)
RUNX1 regulates transcription of genes involved in WNT signaling	Axin-1 Core-binding factor subunit beta Estrogen receptor Forkhead box protein P3 R-spondin-3 Runt-related transcription factor 1	O15169 P03372 Q01196 Q13951 Q9BXY4 Q9BZS1	AML1 AXIN AXIN1 CBFA2 CBFB ESR ESR1 FOXP3 IPEX NR3A1 PWTSR RSPO3 RUNX1 THSD2	Homo sapiens (human)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 M-phase inducer phosphatase 3 Serine/threonine-protein kinase Chk1 Serine/threonine-protein kinase Chk2 Wee1-like protein kinase	O14757 O96017 P06493 P14635 P27348 P30291 P30307 P31946 P31947 P61981 P62258 P63104 Q04917	CCNB CCNB1 CDC2 CDC25C CDC28A CDK1 CDKN1 CDS1 CHEK1 CHEK2 CHK1 CHK2 HME1 P34CDC2 RAD53 SFN WEE1 YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	Homo sapiens (human)
Transcription of the HIV genome	CDK-activating kinase assembly factor MAT1 Cyclin-H Cyclin-dependent kinase 7 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIE subunit 1 General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 TATA-binding protein-associated factor 2N TATA-box-binding protein Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA subunit 2 Transcription initiation factor IIB Transcription initiation factor IIE subunit beta Transcription initiation factor TFIID subunit 1-like Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 11 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 3 Transcription initiation factor TFIID subunit 4 Transcription initiation factor TFIID subunit 4B Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 7-like Transcription initiation factor TFIID subunit 7 Transcription initiation factor TFIID subunit 9 Transcription initiation factor TFIID subunit 9B	O00268 O15514 P13984 P18074 P19387 P19388 P19447 P20226 P21675 P24928 P29083 P29084 P30876 P32780 P35269 P36954 P49848 P50613 P51946 P51948 P52434 P52435 P52655 P52657 P53803 P61218 P62487 P62875 Q00403 Q12962 Q13888 Q13889 Q15542 Q15543 Q15544 Q15545 Q16514 Q16594 Q5H9L4 Q5VWG9 Q6P1X5 Q6ZYL4 Q8IZX4 Q92750 Q92759 Q92804 Q9HBM6	BA2R BTF2 BTF2P44 C6orf175 CAK CAK1 CAP35 CCG1 CCGS CCNH CDK7 CDKN7 CIF150 ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2D1 GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 MAT1 MNAT1 MO15 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF RAP30 RAP74 RBP56 RNF66 RPB7 STK1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1L TAF2 TAF2A TAF2B TAF2C TAF2C1 TAF2C2 TAF2D TAF2E TAF2F TAF2G TAF2H TAF2I TAF2J TAF2K TAF2N TAF2Q TAF3 TAF4 TAF4A TAF4B TAF5 TAF6 TAF7 TAF7L TAF9 TAF9B TAF9L TAFII105 TAFII130 TAFII135 TAFII18 TAFII20 TAFII30 TAFII31 TAFII55 TAFII70 TBP TF2A1 TF2A2 TF2B TF2D TF2E1 TF2E2 TFIIB TFIID TTDA XPB XPBC XPD XPDC	Homo sapiens (human)
Regorafenib-resistant KIT mutants	Mast/stem cell growth factor receptor Kit	P10721	KIT SCFR	Homo sapiens (human)
Regulation of NF-kappa B signaling	Caspase-8 Cellular tumor antigen p53 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibitor of nuclear factor kappa-B kinase-interacting protein Leucine-rich repeat-containing protein 14 NEDD4-binding protein 1 NF-kappa-B essential modulator NLR family member X1 Polyubiquitin-B Polyubiquitin-C Protein NLRC5 TNF receptor-associated factor 2 TNF receptor-associated factor 6 Ubiquitin carboxyl-terminal hydrolase 14 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Ubl carboxyl-terminal hydrolase 18	O14920 O15111 O75113 P04637 P0CG47 P0CG48 P54578 P62979 P62987 Q12933 Q14790 Q15048 Q70UQ0 Q86UT6 Q86WI3 Q9UMW8 Q9Y4K3 Q9Y6K9	CASP8 CHUK FIP3 IKBIP IKBKB IKBKG IKIP IKKA IKKB ISG43 KIAA0014 KIAA0615 LRRC14 MCH5 N4BP1 NEMO NLRC5 NLRX1 NOD27 NOD4 NOD5 NOD9 P53 RNF85 RPS27A TCF16 TGT TP53 TRAF2 TRAF6 TRAP3 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 USP14 USP18	Homo sapiens (human)
Defective SLC12A1 causes Bartter syndrome 1 (BS1)	Solute carrier family 12 member 1	Q13621	NKCC2 SLC12A1	Homo sapiens (human)
Chylomicron assembly	Apolipoprotein A-I Apolipoprotein A-II Apolipoprotein A-IV Apolipoprotein B-100 Apolipoprotein C-II Apolipoprotein C-III Apolipoprotein E Microsomal triglyceride transfer protein large subunit Protein disulfide-isomerase Small COPII coat GTPase SAR1B	P02647 P02649 P02652 P02655 P02656 P04114 P06727 P07237 P55157 Q9Y6B6	APC2 APOA1 APOA2 APOA4 APOB APOC2 APOC3 APOE ERBA2L MTP MTTP P4HB PDI PDIA1 PO4DB SAR1B SARA2 SARB	Homo sapiens (human)
Enhanced cleavage of VWF variant by ADAMTS13	A disintegrin and metalloproteinase with thrombospondin motifs 13 von Willebrand factor	P04275 Q76LX8	ADAMTS13 C9orf8 F8VWF VWF	Homo sapiens (human)
EPH-Ephrin signaling	Ephrin type-A receptor 10 Ephrin type-A receptor 1 Ephrin type-A receptor 2 Ephrin type-A receptor 3 Ephrin type-A receptor 4 Ephrin type-A receptor 5 Ephrin type-A receptor 6 Ephrin type-A receptor 7 Ephrin type-A receptor 8 Ephrin type-B receptor 1 Ephrin type-B receptor 2 Ephrin type-B receptor 3 Ephrin type-B receptor 4 Ephrin type-B receptor 6 Ephrin-A1 Ephrin-A2 Ephrin-A3 Ephrin-A4 Ephrin-A5 Ephrin-B1 Ephrin-B2 Ephrin-B3 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes	O15197 O43921 P06241 P07947 P07948 P20827 P21709 P29317 P29320 P29322 P29323 P52797 P52798 P52799 P52803 P54753 P54756 P54760 P54762 P54764 P98172 Q15375 Q15768 Q5JZY3 Q9UF33	BSK DRT ECK EEK EFL2 EFL3 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EHK1 EHK2 EHK3 ELK EPH EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 EPHT EPHT1 EPHT2 EPHT3 EPLG1 EPLG2 EPLG3 EPLG4 EPLG5 EPLG6 EPLG7 EPLG8 EPTH3 ERK ETK ETK1 ETK2 FYN HEK HEK11 HEK12 HEK2 HEK3 HEK5 HEK6 HEK7 HEK8 HTK HTKL JTK8 KIAA1459 LERK1 LERK2 LERK3 LERK4 LERK5 LERK6 LERK7 LERK8 LYN MYK1 NET SEK TNFAIP4 TYRO1 TYRO11 TYRO4 TYRO5 TYRO6 YES YES1	Homo sapiens (human)
Drug-mediated inhibition of MET activation	Hepatocyte growth factor receptor Hepatocyte growth factor	P08581 P14210	HGF HPTA MET	Homo sapiens (human)
Collagen biosynthesis and modifying enzymes	A disintegrin and metalloproteinase with thrombospondin motifs 14 A disintegrin and metalloproteinase with thrombospondin motifs 2 A disintegrin and metalloproteinase with thrombospondin motifs 3 Bone morphogenetic protein 1 Cartilage-associated protein Collagen alpha-1(I) chain Collagen alpha-1(II) chain Collagen alpha-1(III) chain Collagen alpha-1(IV) chain Collagen alpha-1(IX) chain Collagen alpha-1(V) chain Collagen alpha-1(VI) chain Collagen alpha-1(VII) chain Collagen alpha-1(VIII) chain Collagen alpha-1(X) chain Collagen alpha-1(XI) chain Collagen alpha-1(XII) chain Collagen alpha-1(XIII) chain Collagen alpha-1(XIV) chain Collagen alpha-1(XIX) chain Collagen alpha-1(XV) chain Collagen alpha-1(XVI) chain Collagen alpha-1(XVII) chain Collagen alpha-1(XVIII) chain Collagen alpha-1(XX) chain Collagen alpha-1(XXI) chain Collagen alpha-1(XXII) chain Collagen alpha-1(XXIII) chain Collagen alpha-1(XXIV) chain Collagen alpha-1(XXV) chain Collagen alpha-1(XXVI) chain Collagen alpha-1(XXVII) chain Collagen alpha-1(XXVIII) chain Collagen alpha-2(I) chain Collagen alpha-2(IV) chain Collagen alpha-2(IX) chain Collagen alpha-2(V) chain Collagen alpha-2(VI) chain Collagen alpha-2(VIII) chain Collagen alpha-2(XI) chain Collagen alpha-3(IV) chain Collagen alpha-3(IX) chain Collagen alpha-3(V) chain Collagen alpha-3(VI) chain Collagen alpha-4(IV) chain Collagen alpha-5(IV) chain Collagen alpha-5(VI) chain Collagen alpha-6(IV) chain Collagen alpha-6(VI) chain Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 Peptidyl-prolyl cis-trans isomerase B Procollagen C-endopeptidase enhancer 1 Procollagen C-endopeptidase enhancer 2 Procollagen galactosyltransferase 1 Procollagen galactosyltransferase 2 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 Prolyl 3-hydroxylase 1 Prolyl 3-hydroxylase 2 Prolyl 3-hydroxylase 3 Prolyl 4-hydroxylase subunit alpha-1 Prolyl 4-hydroxylase subunit alpha-2 Prolyl 4-hydroxylase subunit alpha-3 Protein disulfide-isomerase Serpin H1 Tolloid-like protein 1 Tolloid-like protein 2	A6NMZ7 A8TX70 O00469 O15072 O15460 O43897 O60568 O75718 O95450 P02452 P02458 P02461 P02462 P05997 P07237 P08123 P08572 P12107 P12109 P12110 P12111 P13497 P13674 P13942 P20849 P20908 P23284 P25067 P25940 P27658 P29400 P39059 P39060 P50454 P53420 Q01955 Q02388 Q02809 Q03692 Q05707 Q07092 Q14031 Q14050 Q14055 Q14993 Q15113 Q17RW2 Q2UY09 Q32P28 Q5TAT6 Q7Z4N8 Q86Y22 Q8IVL5 Q8IVL6 Q8IYK4 Q8IZC6 Q8NBJ5 Q8NFW1 Q8WXS8 Q96A83 Q96P44 Q99715 Q9BXS0 Q9P218 Q9UKZ9 Q9UMD9 Q9Y6L7	ADAMTS14 ADAMTS2 ADAMTS3 BMP1 BP180 BPAG2 C1orf17 C3orf7 CASP CBP1 CBP2 COL10A1 COL11A1 COL11A2 COL12A1 COL12A1L COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL18A1 COL19A1 COL1A1 COL1A2 COL1AL COL20A1 COL21A1 COL22A1 COL23A1 COL24A1 COL25A1 COL26A1 COL27A1 COL28 COL28A1 COL29A1 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL5A3 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL7A1 COL8A1 COL8A2 COL9A1 COL9A2 COL9A3 COLGALT1 COLGALT2 COLL6 CRTAP CYPB EMID2 EMU2 ERBA2L GLT25D1 GLT25D2 GROS1 HSP47 KIAA0366 KIAA0584 KIAA0932 KIAA1510 KIAA1870 LEPRE1 LEPREL1 LEPREL2 LLH MLAT4 P3H1 P3H2 P3H3 P4HA P4HA1 P4HA2 P4HA3 P4HB PCINP PCOLC PCOLCE PCOLCE2 PCPE1 PCPE2 PCPNI PDI PDIA1 PLOD PLOD1 PLOD2 PLOD3 PO4DB PPIB SERPINH1 SERPINH2 TLL TLL1 TLL2 UND VWA4	Homo sapiens (human)
Iron uptake and transport	Broad substrate specificity ATP-binding cassette transporter ABCG2 Ceruloplasmin Cullin-1 Cullin-associated NEDD8-dissociated protein 1 Cytoplasmic aconitate hydratase F-box/LRR-repeat protein 5 Ferritin heavy chain Ferritin light chain Ferritin, mitochondrial Ferroportin Glutaredoxin-3 Heme oxygenase 1 Heme oxygenase 2 Hephaestin Iron-responsive element-binding protein 2 NEDD8 Natural resistance-associated macrophage protein 2 Neutrophil gelatinase-associated lipocalin Plasma membrane ascorbate-dependent reductase CYBRD1 Polyubiquitin-B Polyubiquitin-C Proton-coupled folate transporter S-phase kinase-associated protein 1 Serotransferrin Solute carrier family 22 member 17 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O76003 P00450 P02787 P02792 P02794 P09601 P0CG47 P0CG48 P21399 P30519 P48200 P49281 P62979 P62987 P63208 P80188 Q13616 Q15843 Q53TN4 Q86VP6 Q8N4E7 Q8WUG5 Q96NT5 Q9BQS7 Q9NP59 Q9UKA1 Q9UNQ0	ABCG2 ABCP ACO1 BCRP BCRP1 BOCT BOIT CAND1 CP CUL1 CYBRD1 DCT1 DCYTB DMT1 EMC19 FBL4 FBL5 FBXL5 FLR1 FPN FPN1 FRRS3 FTH FTH1 FTHL6 FTL FTMT G21 GLRX3 HCP1 HEPH HMOX1 HMOX2 HNL HO HO1 HO2 IREB1 IREB2 IREG1 KIAA0698 KIAA0829 LCN2 MXR NEDD8 NGAL NRAMP2 OCP2 PCFT PICOT RPS27A SKP1 SKP1A SLC11A2 SLC11A3 SLC22A17 SLC40A1 SLC46A1 TCEB1L TF TIP120 TIP120A TXNL2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)

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