GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **1826 - 1850** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▼
Defective HLCS causes multiple carboxylase deficiency	Acetyl-CoA carboxylase 1 Biotin--protein ligase Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial Propionyl-CoA carboxylase alpha chain, mitochondrial Propionyl-CoA carboxylase beta chain, mitochondrial Pyruvate carboxylase, mitochondrial	P05165 P05166 P11498 P50747 Q13085 Q96RQ3 Q9HCC0	ACAC ACACA ACC1 ACCA HLCS MCCA MCCB MCCC1 MCCC2 PC PCCA PCCB
Fatty acyl-CoA biosynthesis	(3R)-3-hydroxyacyl-CoA dehydrogenase 3-oxoacyl-[acyl-carrier-protein] reductase ATP-citrate synthase ATPase MORC2 Acetyl-CoA carboxylase 1 Fatty acid synthase Hydroxyacyl-thioester dehydratase type 2, mitochondrial Long-chain fatty acid transport protein 2 Lysosomal thioesterase PPT2 Palmitoyl-protein thioesterase 1 S-acyl fatty acid synthase thioesterase, medium chain Stearoyl-CoA desaturase 5 Stearoyl-CoA desaturase	O00767 O14975 P49327 P50897 P53396 P86397 Q13085 Q86SK9 Q8N4T8 Q92506 Q9NV23 Q9UMR5 Q9Y6X9	ACAC ACACA ACC1 ACCA ACLY ACOD4 ACSVL1 CBR4 CLN1 FABGL FACVL1 FADS5 FAS FASN FATP2 HKE6 HSD17B8 HTD2 KIAA0852 MORC2 OLAH PPT PPT1 PPT2 RING2 SCD SCD1 SCD2 SCD4 SCD5 SCDOS SDR30C1 SDR45C1 SLC27A2 THEDC1 VLACS ZCWCC1
Biotin transport and metabolism	Acetyl-CoA carboxylase 1 Acetyl-CoA carboxylase 2 Biotin--protein ligase Biotinidase Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial PDZ domain-containing protein 11 Propionyl-CoA carboxylase alpha chain, mitochondrial Propionyl-CoA carboxylase beta chain, mitochondrial Pyruvate carboxylase, mitochondrial Sodium-dependent multivitamin transporter	O00763 P05165 P05166 P11498 P43251 P50747 Q13085 Q5EBL8 Q96RQ3 Q9HCC0 Q9Y289	ACAC ACACA ACACB ACC1 ACC2 ACCA ACCB AIPP1 BTD HLCS MCCA MCCB MCCC1 MCCC2 PC PCCA PCCB PDZD11 PDZK11 PISP SLC5A6 SMVT
Activation of gene expression by SREBF (SREBP)	3'-5' exoribonuclease HELZ2 7-dehydrocholesterol reductase Acetyl-CoA carboxylase 1 Acetyl-CoA carboxylase 2 CREB-binding protein Chromodomain-helicase-DNA-binding protein 9 Delta(14)-sterol reductase TM7SF2 Diphosphomevalonate decarboxylase F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 Farnesyl pyrophosphate synthase Fatty acid synthase Geranylgeranyl pyrophosphate synthase Glycerol-3-phosphate acyltransferase 1, mitochondrial Histone-arginine methyltransferase CARM1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic Isopentenyl-diphosphate Delta-isomerase 1 Lanosterol 14-alpha demethylase Lanosterol synthase Lathosterol oxidase Mediator of RNA polymerase II transcription subunit 1 Metal regulatory transcription factor 1 Mevalonate kinase Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 6 Nuclear transcription factor Y subunit alpha Nuclear transcription factor Y subunit beta Nuclear transcription factor Y subunit gamma Peroxisome proliferator-activated receptor alpha Phosphomevalonate kinase Retinoic acid receptor RXR-alpha SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Squalene monooxygenase Squalene synthase Stearoyl-CoA desaturase Sterol regulatory element-binding protein 2 Transcription factor Sp1 Trimethylguanosine synthase Very long chain fatty acid elongase 6	O00763 O00767 O60907 O75845 O76062 O95749 P08047 P14324 P19793 P23511 P25208 P37268 P48449 P49327 P53602 Q01581 Q03426 Q07869 Q12772 Q13085 Q13907 Q13952 Q14534 Q14686 Q14872 Q15126 Q15596 Q15648 Q15788 Q16850 Q3L8U1 Q6STE5 Q86X55 Q92793 Q96RS0 Q9BYK8 Q9BZK7 Q9H5J4 Q9HCL2 Q9UBM7	ACAC ACACA ACACB ACC1 ACC2 ACCA ACCB AIB3 ANG1 ARC205 BAF60C BHLHD2 BHLHE74 BHLHE75 CARM1 CBP CHD9 CREBBP CRSP1 CRSP200 CYP51 CYP51A1 D7SR DHCR7 DRIP205 DRIP230 ELOVL6 ERG1 FACE FADS5 FAS FASN FDFT1 FDPS FPS GGPS1 GPAM GPAT1 HAP3 HCA137 HELZ2 HMGCS HMGCS1 IDI1 IRA1 KIAA0181 KIAA0308 KIAA1293 KIAA1560 KIAA1769 KISH2 LCE LSS MED1 MPD MTF1 MVD MVK NCOA1 NCOA2 NCOA6 NCOA6IP NFYA NFYB NFYC NR1C1 NR2B1 OSC PBP PIMT PMKI PMVK PPAR PPARA PPARBP PPARGBP PRIC285 PRIC320 PRMT4 RAP250 RB18A RXRA SC5D SC5DL SCD SCD1 SCDOS SMARCD3 SP1 SQLE SRC1 SRC2 SREBF2 SREBP2 TBL1 TBL1X TBL1XR1 TBLR1 TGS1 TIF2 TM7SF2 TRAP220 TRBP TRIP2 TSFP1
ChREBP activates metabolic gene expression	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha ATP-citrate synthase Acetyl-CoA carboxylase 1 Acetyl-CoA carboxylase 2 Carbohydrate-responsive element-binding protein Fatty acid synthase Max-like protein X	O00763 P49327 P53396 Q13085 Q99943 Q9NP71 Q9UH92	ACAC ACACA ACACB ACC1 ACC2 ACCA ACCB ACLY AGPAT1 BHLHD13 BHLHD14 FAS FASN G15 MIO MLX MLXIPL TCFL4 WBSCR14
Mitochondrial Fatty Acid Beta-Oxidation	3-ketoacyl-CoA thiolase, mitochondrial Acetyl-coenzyme A thioesterase Acyl carrier protein, mitochondrial Acyl-CoA dehydrogenase family member 10 Acyl-CoA dehydrogenase family member 11 Acyl-CoA-binding domain-containing protein 6 Acyl-CoA-binding domain-containing protein 7 Acyl-CoA-binding protein Acyl-coenzyme A thioesterase 11 Acyl-coenzyme A thioesterase 13 Acyl-coenzyme A thioesterase 1 Acyl-coenzyme A thioesterase 2, mitochondrial Acyl-coenzyme A thioesterase 9, mitochondrial Acyl-coenzyme A thioesterase THEM4 Acyl-coenzyme A thioesterase THEM5 Cytosolic acyl coenzyme A thioester hydrolase Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Medium-chain acyl-CoA ligase ACSF2, mitochondrial Phosphatidylcholine transfer protein Putative cytosolic acyl coenzyme A thioester hydrolase-like	O00154 O14561 P07108 P42765 P49753 Q5T1C6 Q6JQN1 Q6ZUV0 Q709F0 Q86TX2 Q8IVS2 Q8N1Q8 Q8N6N7 Q8WXI4 Q8WYK0 Q96CM8 Q9BR61 Q9NPJ3 Q9UKL6 Q9Y305	ACAA2 ACAD10 ACAD11 ACBD6 ACBD7 ACOT1 ACOT11 ACOT12 ACOT13 ACOT15 ACOT2 ACOT7 ACOT7L ACOT9 ACSF2 BACH BACHL BFIT CACH CACH1 CTE1 CTMP DBI KIAA0707 MCAT MT NDUFAB1 PCTP PTE2 PTE2A STARD15 STARD2 THEA THEM2 THEM4 THEM5
TYSND1 cleaves peroxisomal proteins	3-ketoacyl-CoA thiolase, peroxisomal Alkyldihydroxyacetonephosphate synthase, peroxisomal Peroxisomal acyl-coenzyme A oxidase 1 Peroxisomal leader peptide-processing protease Peroxisomal multifunctional enzyme type 2 Phytanoyl-CoA dioxygenase, peroxisomal Sterol carrier protein 2	O00116 O14832 P09110 P22307 P51659 Q15067 Q2T9J0	ACAA ACAA1 ACOX ACOX1 AGPS EDH17B4 HSD17B4 PAHX PHYH PTHIO SCP2 SDR8C1 TYSND1
Peroxisomal protein import	2-Hydroxyacid oxidase 1 2-Hydroxyacid oxidase 2 2-hydroxyacyl-CoA lyase 1 3-ketoacyl-CoA thiolase, peroxisomal AN1-type zinc finger protein 6 Acyl-coenzyme A diphosphatase NUDT19 Acyl-coenzyme A thioesterase 2, mitochondrial Acyl-coenzyme A thioesterase 8 Alanine--glyoxylate aminotransferase Alkyldihydroxyacetonephosphate synthase, peroxisomal Alpha-methylacyl-CoA racemase Bifunctional epoxide hydrolase 2 Bile acid-CoA Carnitine O-acetyltransferase Catalase D-amino-acid oxidase D-aspartate oxidase Dehydrogenase/reductase SDR family member 4 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Dihydroxyacetone phosphate acyltransferase Glutathione S-transferase kappa 1 Hydroxymethylglutaryl-CoA lyase, mitochondrial Insulin-degrading enzyme Isocitrate dehydrogenase [NADP] cytoplasmic Lon protease homolog 2, peroxisomal Long-chain fatty acid transport protein 2 Nitric oxide synthase, inducible Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] Peroxisomal ATPase PEX1 Peroxisomal ATPase PEX6 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase Peroxisomal acyl-coenzyme A oxidase 1 Peroxisomal acyl-coenzyme A oxidase 2 Peroxisomal acyl-coenzyme A oxidase 3 Peroxisomal bifunctional enzyme Peroxisomal carnitine O-octanoyltransferase Peroxisomal coenzyme A diphosphatase NUDT7 Peroxisomal leader peptide-processing protease Peroxisomal membrane protein PEX13 Peroxisomal membrane protein PEX14 Peroxisomal multifunctional enzyme type 2 Peroxisomal sarcosine oxidase Peroxisomal succinyl-coenzyme A thioesterase Peroxisomal targeting signal 2 receptor Peroxisomal trans-2-enoyl-CoA reductase Peroxisome assembly protein 12 Peroxisome assembly protein 26 Peroxisome biogenesis factor 10 Peroxisome biogenesis factor 2 Phytanoyl-CoA dioxygenase, peroxisomal Polyubiquitin-B Polyubiquitin-C Protein Mpv17 Sterol carrier protein 2 Ubiquitin carboxyl-terminal hydrolase 9X Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A8MXV4 O00116 O00623 O00628 O14734 O14832 O14975 O15228 O15254 O43933 O60683 O75381 O75874 P04040 P09110 P0C024 P0CG47 P0CG48 P14735 P14920 P21549 P22307 P28328 P34913 P35228 P35914 P39210 P43155 P49753 P51659 P51668 P61077 P62837 P62979 P62987 Q08426 Q13011 Q13608 Q14032 Q15067 Q2T9J0 Q6FIF0 Q6QHF9 Q7Z412 Q86WA8 Q8N9L9 Q92968 Q93008 Q99424 Q99489 Q9BTZ2 Q9BY49 Q9NUI1 Q9NYQ3 Q9P0Z9 Q9UHK6 Q9UJ83 Q9UJM8 Q9UKG9 Q9Y2Q3	ACAA ACAA1 ACOT2 ACOT4 ACOT8 ACOX ACOX1 ACOX2 ACOX3 ACSVL1 ACTEIII AGPS AGT1 AGXT AMACR AWP1 BAAT BRCOX CAT CAT1 COT CRAT CROT DAMOX DAO DAPAT DDO DECR2 DFFRX DHAPAT DHRS4 ECH1 ECHD EDH17B4 EHHADH EPHX2 FACVL1 FAM FATP2 GNPAT GOX1 GSTK1 HACL1 HAO1 HAO2 HAOX2 HMGCL HPCL HPCL2 HSD17B4 IDE IDH1 LONP LONP2 LPIPOX MPV17 NOS2 NOS2A NUDT19 NUDT7 PAF1 PAF3 PAHX PAO PAOX PDCR PECR PEX1 PEX10 PEX12 PEX13 PEX14 PEX2 PEX26 PEX6 PEX7 PHYH PHYH2 PICD PIPOX PMP3 PMP35 PRCOX PSO PTE1 PTE2 PTE2A PTE2B PTEIB PTHIO PTS2R PUBC1 PXAAA1 PXMP3 RNF69 RNF72 RPS27A SCP2 SDR17C1 SDR25C2 SDR29C1 SDR8C1 SFT SLC27A2 SPAT TYSND1 UBA52 UBA80 UBB UBC UBC4 UBC5A UBC5B UBC5C UBCEP1 UBCEP2 UBCH4 UBCH5 UBCH5A UBCH5B UBCH5C UBE2D1 UBE2D2 UBE2D3 USP9 USP9X VLACS ZA20D3 ZFAND6
IRF3-mediated induction of type I IFN	DNA-dependent protein kinase catalytic subunit Double-strand break repair protein MRE11 E3 ubiquitin-protein ligase DTX4 Gamma-interferon-inducible protein 16 Interferon regulatory factor 3 NACHT, LRR and PYD domains-containing protein 4 NLR family CARD domain-containing protein 3 Probable ATP-dependent RNA helicase DDX41 Serine/threonine-protein kinase TBK1 Stimulator of interferon genes protein Three-prime repair exonuclease 1 X-ray repair cross-complementing protein 5 X-ray repair cross-complementing protein 6	P12956 P13010 P49959 P78527 Q14653 Q16666 Q7RTR2 Q86WV6 Q96MN2 Q9NSU2 Q9UHD2 Q9UJV9 Q9Y2E6	ABS DDX41 DTX4 ERIS G22P1 G22P2 HNGS1 HYRC HYRC1 IFI16 IFNGIP1 IRF3 KIAA0937 MITA MRE11 MRE11A NAK NALP4 NLRC3 NLRP4 NOD3 PAN2 PRKDC PYPAF4 RNF155 RNH2 STING STING1 TBK1 TMEM173 TREX1 XRCC5 XRCC6
STING mediated induction of host immune responses	Cyclic GMP-AMP synthase E3 ubiquitin-protein ligase TRIM21 Gamma-interferon-inducible protein 16 Probable ATP-dependent RNA helicase DDX41 Stimulator of interferon genes protein	P19474 Q16666 Q86WV6 Q8N884 Q9UJV9	ABS C6orf150 CGAS DDX41 ERIS IFI16 IFNGIP1 MB21D1 MITA RNF81 RO52 SSA1 STING STING1 TMEM173 TRIM21
Regulation of innate immune responses to cytosolic DNA	E3 ubiquitin-protein ligase DTX4 E3 ubiquitin-protein ligase TRIM21 E3 ubiquitin-protein ligase TRIM32 E3 ubiquitin-protein ligase TRIM56 Interferon regulatory factor 3 NACHT, LRR and PYD domains-containing protein 4 Polyubiquitin-B Polyubiquitin-C Probable ATP-dependent RNA helicase DDX41 Serine/threonine-protein kinase TBK1 Stimulator of interferon genes protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Z-DNA-binding protein 1	P0CG47 P0CG48 P19474 P62979 P62987 Q13049 Q14653 Q86WV6 Q96MN2 Q9BRZ2 Q9H171 Q9UHD2 Q9UJV9 Q9Y2E6	ABS C20orf183 DDX41 DLM1 DTX4 ERIS HT2A IRF3 KIAA0937 MITA NAK NALP4 NLRP4 PAN2 PYPAF4 RNF109 RNF155 RNF81 RNH2 RO52 RPS27A SSA1 STING STING1 TBK1 TMEM173 TRIM21 TRIM32 TRIM56 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 ZBP1
pre-mRNA splicing	116 kDa U5 small nuclear ribonucleoprotein component 17S U2 SnRNP complex component HTATSF1 ATP-dependent RNA helicase A ATP-dependent RNA helicase DDX42 ATP-dependent RNA helicase DHX15 ATP-dependent RNA helicase DHX8 Apoptotic chromatin condensation inducer in the nucleus BUD13 homolog Beta-catenin-like protein 1 CWF19-like protein 2 Calcium homeostasis endoplasmic reticulum protein Cell division cycle 5-like protein Cell division cycle and apoptosis regulator protein 1 Coiled-coil domain-containing protein 12 Crooked neck-like protein 1 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 DnaJ homolog subfamily C member 8 E3 ubiquitin-protein ligase RNF113A Eukaryotic initiation factor 4A-III Exosome RNA helicase MTR4 G patch domain-containing protein 1 G-patch domain and KOW motifs-containing protein General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 Heat shock cognate 71 kDa protein Heterogeneous nuclear ribonucleoprotein A1 Heterogeneous nuclear ribonucleoprotein A3 Heterogeneous nuclear ribonucleoprotein D0 Heterogeneous nuclear ribonucleoprotein F Heterogeneous nuclear ribonucleoprotein H2 Heterogeneous nuclear ribonucleoprotein H Heterogeneous nuclear ribonucleoprotein K Heterogeneous nuclear ribonucleoprotein L Heterogeneous nuclear ribonucleoprotein M Heterogeneous nuclear ribonucleoprotein R Heterogeneous nuclear ribonucleoprotein U Heterogeneous nuclear ribonucleoproteins A2/B1 Heterogeneous nuclear ribonucleoproteins C1/C2 Histone deacetylase complex subunit SAP18 Intron Large complex component GCFC2 Leukocyte receptor cluster member 1 Luc7-like protein 3 Microfibrillar-associated protein 1 NF-kappa-B-activating protein NHP2-like protein 1 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Nuclear inhibitor of protein phosphatase 1 Nuclear speckle splicing regulatory protein 1 PHD finger-like domain-containing protein 5A PRKR-interacting protein 1 Peptidyl-prolyl cis-trans isomerase E Peptidyl-prolyl cis-trans isomerase G Peptidyl-prolyl cis-trans isomerase H Peptidyl-prolyl cis-trans isomerase-like 1 Peptidyl-prolyl cis-trans isomerase-like 3 Peptidyl-prolyl cis-trans isomerase-like 4 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 Pinin Pleiotropic regulator 1 Poly(U)-binding-splicing factor PUF60 Poly(rC)-binding protein 1 Poly(rC)-binding protein 2 Polyglutamine-binding protein 1 Polypyrimidine tract-binding protein 1 Pre-mRNA-processing factor 17 Pre-mRNA-processing factor 19 Pre-mRNA-processing factor 40 homolog A Pre-mRNA-processing factor 6 Pre-mRNA-processing-splicing factor 8 Pre-mRNA-splicing factor 18 Pre-mRNA-splicing factor 38A Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 Pre-mRNA-splicing factor CWC22 homolog Pre-mRNA-splicing factor CWC25 homolog Pre-mRNA-splicing factor ISY1 homolog Pre-mRNA-splicing factor RBM22 Pre-mRNA-splicing factor SLU7 Pre-mRNA-splicing factor SPF27 Pre-mRNA-splicing factor SYF1 Pre-mRNA-splicing factor SYF2 Probable ATP-dependent RNA helicase DDX23 Probable ATP-dependent RNA helicase DDX41 Probable ATP-dependent RNA helicase DDX46 Probable ATP-dependent RNA helicase DDX5 Probable ATP-dependent RNA helicase DHX35 Proline-rich protein PRCC Protein BUD31 homolog Protein CASC3 Protein FAM32A Protein FAM50A Protein Red Protein mago nashi homolog 2 Protein mago nashi homolog RING-type E3 ubiquitin-protein ligase PPIL2 RNA helicase aquarius RNA-binding motif protein, X chromosome RNA-binding motif protein, X-linked 2 RNA-binding protein 10 RNA-binding protein 25 RNA-binding protein 39 RNA-binding protein 42 RNA-binding protein 5 RNA-binding protein 7 RNA-binding protein 8A RNA-binding protein FUS RNA-binding protein with serine-rich domain 1 Regulator of nonsense transcripts 3B SNW domain-containing protein 1 STING ER exit protein SURP and G-patch domain-containing protein 1 Serine/arginine repetitive matrix protein 1 Serine/arginine repetitive matrix protein 2 Serine/arginine-rich splicing factor 10 Serine/arginine-rich splicing factor 11 Serine/arginine-rich splicing factor 12 Serine/arginine-rich splicing factor 1 Serine/arginine-rich splicing factor 2 Serine/arginine-rich splicing factor 3 Serine/arginine-rich splicing factor 4 Serine/arginine-rich splicing factor 5 Serine/arginine-rich splicing factor 6 Serine/arginine-rich splicing factor 7 Serine/arginine-rich splicing factor 8 Serine/arginine-rich splicing factor 9 Serine/threonine-protein kinase PRP4 homolog Serrate RNA effector molecule homolog Smad nuclear-interacting protein 1 Small nuclear ribonucleoprotein E Small nuclear ribonucleoprotein F Small nuclear ribonucleoprotein G Small nuclear ribonucleoprotein Sm D1 Small nuclear ribonucleoprotein Sm D2 Small nuclear ribonucleoprotein Sm D3 Small nuclear ribonucleoprotein-associated protein N Small nuclear ribonucleoprotein-associated proteins B and B' Spliceosome RNA helicase DDX39B Spliceosome-associated protein CWC15 homolog Spliceosome-associated protein CWC27 homolog Splicing factor 1 Splicing factor 3A subunit 1 Splicing factor 3A subunit 2 Splicing factor 3A subunit 3 Splicing factor 3B subunit 1 Splicing factor 3B subunit 2 Splicing factor 3B subunit 3 Splicing factor 3B subunit 4 Splicing factor 3B subunit 5 Splicing factor 3B subunit 6 Splicing factor 45 Splicing factor C9orf78 Splicing factor Cactin Splicing factor U2AF 26 kDa subunit Splicing factor U2AF 35 kDa subunit Splicing factor U2AF 65 kDa subunit Splicing factor YJU2 Splicing regulator SDE2 Survival of motor neuron-related-splicing factor 30 THO complex subunit 4 Thioredoxin-like protein 4A Transcription elongation regulator 1 Transformer-2 protein homolog beta Tuftelin-interacting protein 11 U1 small nuclear ribonucleoprotein 70 kDa U1 small nuclear ribonucleoprotein A U1 small nuclear ribonucleoprotein C U2 small nuclear ribonucleoprotein A' U2 small nuclear ribonucleoprotein B'' U2 snRNP-associated SURP motif-containing protein U4/U6 small nuclear ribonucleoprotein Prp31 U4/U6 small nuclear ribonucleoprotein Prp3 U4/U6 small nuclear ribonucleoprotein Prp4 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein U4/U6.U5 tri-snRNP-associated protein 1 U5 small nuclear ribonucleoprotein 200 kDa helicase U5 small nuclear ribonucleoprotein 40 kDa protein U6 snRNA-associated Sm-like protein LSm2 U6 snRNA-associated Sm-like protein LSm3 U6 snRNA-associated Sm-like protein LSm4 U6 snRNA-associated Sm-like protein LSm5 U6 snRNA-associated Sm-like protein LSm6 U6 snRNA-associated Sm-like protein LSm7 U6 snRNA-associated Sm-like protein LSm8 Ubiquitin carboxyl-terminal hydrolase 39 Ubiquitin-like protein 5 WD repeat-containing protein 70 WD40 repeat-containing protein SMU1 WW domain-binding protein 11 WW domain-binding protein 4 Y-box-binding protein 1 Zinc finger matrin-type protein 2 Zinc finger protein 830	O00422 O14776 O15042 O15234 O15514 O15541 O43143 O43172 O43290 O43390 O43395 O43447 O43660 O43719 O60231 O60306 O60508 O60828 O75400 O75494 O75533 O75554 O75643 O75934 O75937 O75940 O94906 O95232 O95391 O95777 O95926 P07910 P08579 P08621 P09012 P09234 P09651 P09661 P11142 P13984 P14678 P14866 P16383 P17844 P19387 P19388 P22626 P24928 P26368 P26599 P30876 P31943 P35269 P35637 P36954 P38159 P38919 P41223 P42285 P49756 P51991 P52272 P52298 P52434 P52435 P52597 P52756 P53803 P55081 P55769 P55795 P61218 P61326 P61978 P62304 P62306 P62308 P62310 P62312 P62314 P62316 P62318 P62487 P62875 P62995 P63162 P67809 P83876 P84103 P98175 Q00839 Q01081 Q01130 Q05519 Q07955 Q08170 Q08211 Q09161 Q12874 Q12972 Q13123 Q13242 Q13243 Q13247 Q13356 Q13427 Q13435 Q13523 Q13573 Q13838 Q14103 Q14320 Q14498 Q14562 Q15029 Q15287 Q15365 Q15366 Q15393 Q15427 Q15428 Q15459 Q15637 Q16629 Q2TAY7 Q2TBE0 Q53GS9 Q6IQ49 Q6P2Q9 Q6UX04 Q7L014 Q7RTV0 Q86V81 Q86XP3 Q8IWX8 Q8IWZ8 Q8IX12 Q8IYB3 Q8N5F7 Q8NAV1 Q8TAD8 Q8WU68 Q8WUA2 Q8WUD4 Q8WUQ7 Q8WVK2 Q8WWY3 Q8WXF0 Q8WYA6 Q92620 Q92733 Q92917 Q96A72 Q96BP3 Q96BZ8 Q96DI7 Q96I25 Q96NB3 Q96NC0 Q99459 Q99633 Q9BRD0 Q9BRL6 Q9BRR8 Q9BTD8 Q9BUQ8 Q9BW85 Q9BWJ5 Q9BXP5 Q9BZI7 Q9BZJ0 Q9BZL1 Q9H0G5 Q9H2H8 Q9H307 Q9H5V9 Q9H5Z1 Q9H875 Q9HCG8 Q9HCS7 Q9NW64 Q9NW82 Q9NXE8 Q9NZ63 Q9P013 Q9UBB9 Q9UHX1 Q9UJV9 Q9UK45 Q9UKV3 Q9ULR0 Q9UMS4 Q9UNP9 Q9UQ35 Q9Y2W2 Q9Y333 Q9Y388 Q9Y3B4 Q9Y3C6 Q9Y421 Q9Y4Y9 Q9Y4Z0 Q9Y580 Q9Y5S9	ABS ACIN1 ACINUS ALY ALYREF AQR ARD1 ARS2 ASCC3L1 ASF ASR2 AUF1 BAT1 BCAS2 BEF BRR2 BUD13 BUD31 C11orf5 C19orf29 C1orf199 C1orf55 C20orf14 C20orf15 C20orf33 C2orf3 C6orf28 C9orf78 CA150 CACTIN CARP1 CASC3 CBP20 CBP80 CBPIN CCAR1 CCDC12 CCDC16 CCDC49 CCDC55 CCDC94 CDC40 CDC5L CHERP COD CREAP1 CRN CRNKL1 CROP CTNNBL1 CWC15 CWC22 CWC25 CWC27 CWF19L2 CXorf56 CYP20 CYP33 CYPH CYPL1 DAM1 DAN26 DBP1 DBP2 DDX15 DDX16 DDX23 DDX35 DDX38 DDX39B DDX41 DDX42 DDX46 DDX48 DDX5 DDX8 DDX9 DHX15 DHX16 DHX35 DHX38 DHX8 DHX9 DIM1 DIS DNAJC8 DOB1 DRS DXS8237E DXS9928E ECGP EDG2 EFTUD2 EHB3 EIF4A3 FAM32A FAM50A FBP11 FBP21 FIR FLAF1 FNBP21 FNBP3 FTP3 FUS FUSIP1 FUSIP2 G17P1 G7B GCF GCFC2 GCIPIP GPATC1 GPATC5 GPATC9 GPATCH1 GPATCH5 GPATCH9 GPKOW GTF2F1 GTF2F2 HCA59 HCC1 HCERN3 HCNP HELIC2 HELR HIP10 HLR1 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPM HNRNPR HNRNPU HNRPA1 HNRPA2B1 HNRPA3 HNRPC HNRPD HNRPF HNRPG HNRPH HNRPH1 HNRPH2 HNRPK HNRPL HNRPM HNRPR HNRPU HPRP18 HPRP3 HRS HSC70 HSP73 HSPA10 HSPA8 HTATSF1 HXC26 HYPA IK ISY1 KIAA0017 KIAA0031 KIAA0052 KIAA0073 KIAA0111 KIAA0122 KIAA0224 KIAA0324 KIAA0332 KIAA0432 KIAA0536 KIAA0560 KIAA0577 KIAA0670 KIAA0788 KIAA0801 KIAA1160 KIAA1177 KIAA1604 LDC2 LENG1 LKP LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 LUC7L3 MAGOH MAGOH2 MAGOHA MAGOHB MEMA MFAP1 MLN51 MTR4 MTREX NAGR1 NCBP NCBP1 NCBP2 NCM NDH2 NHP2L1 NIPP1 NKAP NMP200 NPW38 NPWBP NSEP1 NSRP1 NSRP70 O48 OTAG12 PBSCF PBSCG PCBP1 PCBP2 PCDC5RP PHF5A PLRG1 PNN POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF PPIE PPIG PPIH PPIL1 PPIL2 PPIL3 PPIL4 PPP1R8 PPWD1 PQBP1 PRCC PRKRIP1 PRP16 PRP17 PRP19 PRP2 PRP3 PRP31 PRP4 PRP4B PRP4H PRP4K PRP8BP PRPC8 PRPF17 PRPF18 PRPF19 PRPF3 PRPF31 PRPF38A PRPF4 PRPF40A PRPF4K PRPF6 PRPF8 PTB PTBP1 PUF60 RAP30 RAP74 RBM10 RBM17 RBM22 RBM25 RBM39 RBM42 RBM5 RBM7 RBM8 RBM8A RBMX RBMX2 RBMXP1 RED RENT3B RER RNF113 RNF113A RNPC2 RNPC7 RNPS1 RNPU1Z ROBPI RPB7 RPU1 SAFA SAP114 SAP130 SAP14 SAP145 SAP155 SAP18 SAP49 SAP61 SAP62 SART1 SCAF6 SDCCAG10 SDE2 SF1 SF2 SF2P33 SF3A1 SF3A2 SF3A3 SF3B1 SF3B10 SF3B14 SF3B14A SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SF4 SFP38 SFRS1 SFRS10 SFRS11 SFRS13A SFRS13B SFRS19 SFRS2 SFRS2B SFRS3 SFRS4 SFRS5 SFRS6 SFRS7 SFRS9 SIAHBP1 SIPP1 SKIIP SKIP SKIV2L2 SLU7 SMN SMNDC1 SMNR SMU1 SNEV SNIP1 SNP70 SNRNP200 SNRNP27 SNRNP40 SNRNP70 SNRP116 SNRP70 SNRPA SNRPA1 SNRPB SNRPB1 SNRPB2 SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNRPN SNU13 SNW1 SPF30 SPF31 SPF45 SR140 SRL300 SRM160 SRM300 SRP20 SRP30C SRP40 SRP46 SRP55 SRP75 SRRM1 SRRM2 SRRP35 SRRT SRSF1 SRSF10 SRSF11 SRSF12 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SRSF9 STEEP1 STIP SUGP1 SYF1 SYF2 T54 TAF2S TASR TCERG1 TCF9 TFIP11 THOC4 TLS TPRC TRA2B TXNL4 TXNL4A U1AP1 U21.1 U2AF1 U2AF1-RS3 U2AF1L3 U2AF1L4 U2AF2 U2AF35 U2AF65 U2AFBP U2SURP UAP56 UBL5 UPF3B UPF3X USP39 WBP11 WBP4 WDR57 WDR70 XAB2 XAP5 YB1 YBX1 YJU2 ZC3H16 ZFM1 ZMAT2 ZNF162 ZNF183 ZNF830
Nonhomologous End-Joining (NHEJ)	BRCA1-A complex subunit Abraxas 1 BRCA1-A complex subunit RAP80 BRCA1-associated RING domain protein 1 BRISC and BRCA1-A complex member 1 BRISC and BRCA1-A complex member 2 Breast cancer type 1 susceptibility protein DNA ligase 4 DNA polymerase lambda DNA repair protein RAD50 DNA repair protein XRCC4 DNA-dependent protein kinase catalytic subunit DNA-directed DNA/RNA polymerase mu Double-strand break repair protein MRE11 E3 SUMO-protein ligase PIAS4 E3 ubiquitin-protein ligase HERC2 E3 ubiquitin-protein ligase RNF168 E3 ubiquitin-protein ligase RNF8 Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1t Histone H4 Histone acetyltransferase KAT5 Histone-lysine N-methyltransferase NSD2 Lys-63-specific deubiquitinase BRCC36 Mediator of DNA damage checkpoint protein 1 Nibrin Non-homologous end-joining factor 1 PAX-interacting protein 1 Protein artemis Serine-protein kinase ATM TP53-binding protein 1 Telomere-associated protein RIF1 Tyrosyl-DNA phosphodiesterase 1 Tyrosyl-DNA phosphodiesterase 2 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 2 X-ray repair cross-complementing protein 5 X-ray repair cross-complementing protein 6	O60814 O60934 O76064 O95551 O95714 O96028 P06899 P12956 P13010 P16104 P23527 P33778 P38398 P46736 P49917 P49959 P57053 P58876 P61088 P62805 P62807 P78527 Q12888 Q13315 Q13426 Q14676 Q15819 Q16695 Q16778 Q5UIP0 Q6UWZ7 Q6ZW49 Q8IYW5 Q8N257 Q8N2W9 Q92878 Q92993 Q93079 Q96A08 Q96RL1 Q96SD1 Q99728 Q99877 Q99879 Q99880 Q9H9Q4 Q9NP87 Q9NUW8 Q9NWV8 Q9NXR7 Q9UGP5	ABRA1 ABRAXAS1 ARTEMIS ASCID ATM BABAM1 BABAM2 BARD1 BLU BRCA1 BRCC3 BRCC36 BRCC45 BRE C19orf62 C6.1A CCDC98 CXorf53 DCLRE1C EAP2 FAM175A G22P1 G22P2 H2AFX H2AX H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-4 H3FT H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HERC2 HIRIP1 HIRIP2 HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2BE HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 HNGS1 HTATIP HYRC HYRC1 KAT5 KIAA0170 KIAA0646 KIAA1090 LIG4 MDC1 MERIT40 MMS2 MMSET MRE11 MRE11A NBA1 NBN NBS NBS1 NFBD1 NHEJ1 NSD2 P95 PAXIP1 PAXIP1L PIAS4 PIASG POLL POLM PRKDC PTIP RAD50 RAP80 RIF1 RNF168 RNF53 RNF8 RXRIP110 SCIDA SNM1C TDP1 TDP2 TIP60 TP53BP1 TRX5 TSH2B TTRAP UBE2N UBE2V2 UEV2 UIMC1 WHSC1 XLF XRCC4 XRCC5 XRCC6 polmu
G2/M DNA damage checkpoint	ATR-interacting protein BRCA1-A complex subunit Abraxas 1 BRCA1-A complex subunit RAP80 BRCA1-associated RING domain protein 1 BRISC and BRCA1-A complex member 1 BRISC and BRCA1-A complex member 2 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Cell cycle checkpoint control protein RAD9A Cell cycle checkpoint control protein RAD9B Cell cycle checkpoint protein RAD17 Cell cycle checkpoint protein RAD1 Cellular tumor antigen p53 Checkpoint protein HUS1 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 2-binding protein 1 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 E3 SUMO-protein ligase PIAS4 E3 ubiquitin-protein ligase HERC2 E3 ubiquitin-protein ligase RNF168 E3 ubiquitin-protein ligase RNF8 Exonuclease 1 Fanconi anemia group J protein Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1t Histone H4 Histone acetyltransferase KAT5 Histone-lysine N-methyltransferase NSD2 Lys-63-specific deubiquitinase BRCC36 Mediator of DNA damage checkpoint protein 1 Nibrin RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Serine/threonine-protein kinase ATR Serine/threonine-protein kinase Chk1 Serine/threonine-protein kinase Chk2 TP53-binding protein 1 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 2	O14757 O60671 O60814 O60921 O60934 O75943 O76064 O95714 O96017 O96028 P04637 P06899 P15927 P16104 P23527 P27694 P33778 P35244 P35249 P35250 P38398 P40937 P40938 P46736 P49959 P51530 P54132 P57053 P58876 P61088 P62805 P62807 Q12888 Q13315 Q13472 Q13535 Q14191 Q14676 Q15819 Q16695 Q16778 Q6UWZ7 Q6WBX8 Q8IYW5 Q8N257 Q8N2W9 Q8WXE1 Q92547 Q92878 Q92993 Q93079 Q96A08 Q96E14 Q96RL1 Q99638 Q99708 Q99728 Q99877 Q99879 Q99880 Q9BSD3 Q9BX63 Q9H9A7 Q9NWV8 Q9NXR7 Q9UQ84	ABRA1 ABRAXAS1 AGS1 ATM ATR ATRIP BABAM1 BABAM2 BACH1 BARD1 BLM BLU BRCA1 BRCC3 BRCC36 BRCC45 BRE BRIP1 C12orf32 C16orf75 C19orf62 C6.1A C9orf76 CCDC98 CDS1 CHEK1 CHEK2 CHK1 CHK2 CTIP CXorf53 DNA2 DNA2L EXO1 EXOI FAM175A FANCJ FRP1 H2AFX H2AX H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-4 H3FT H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HERC2 HEX1 HIRIP1 HIRIP2 HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2BE HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 HNGS1 HTATIP HUS1 KAT5 KIAA0083 KIAA0170 KIAA0259 KIAA0646 KIAA1090 MDC1 MERIT40 MMS2 MMSET MRE11 MRE11A NBA1 NBN NBS NBS1 NFBD1 NSD2 P53 P95 PIAS4 PIASG R24L RAD1 RAD17 RAD50 RAD53 RAD9A RAD9B RAP80 RBBP8 REC1 RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC2 RFC3 RFC4 RFC5 RHINO RHNO1 RMI1 RMI2 RNF168 RNF53 RNF8 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RXRIP110 TIP60 TOP3 TOP3A TOPBP1 TP53 TP53BP1 TRX5 TSH2B UBE2N UBE2V2 UEV2 UIMC1 WHSC1 WRN
Processing of DNA double-strand break ends	ATR-interacting protein BRCA1-A complex subunit Abraxas 1 BRCA1-A complex subunit RAP80 BRCA1-associated RING domain protein 1 BRISC and BRCA1-A complex member 1 BRISC and BRCA1-A complex member 2 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Cell cycle checkpoint control protein RAD9A Cell cycle checkpoint control protein RAD9B Cell cycle checkpoint protein RAD17 Cell cycle checkpoint protein RAD1 Checkpoint protein HUS1 Claspin Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 2 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 2-binding protein 1 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 E3 SUMO-protein ligase PIAS4 E3 ubiquitin-protein ligase HERC2 E3 ubiquitin-protein ligase RNF168 E3 ubiquitin-protein ligase RNF4 E3 ubiquitin-protein ligase RNF8 Exonuclease 1 Fanconi anemia group J protein Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1t Histone H4 Histone acetyltransferase KAT5 Histone-lysine N-methyltransferase NSD2 Lys-63-specific deubiquitinase BRCC36 Mediator of DNA damage checkpoint protein 1 NAD-dependent protein deacylase sirtuin-6 Nibrin Polyubiquitin-B Polyubiquitin-C Protein timeless homolog RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit SUMO-conjugating enzyme UBC9 Serine-protein kinase ATM Serine/threonine-protein kinase ATR Serine/threonine-protein kinase Chk1 Serine/threonine-protein phosphatase 4 catalytic subunit Serine/threonine-protein phosphatase 4 regulatory subunit 2 Small ubiquitin-related modifier 2 TIMELESS-interacting protein TP53-binding protein 1 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14757 O60671 O60814 O60921 O60934 O75943 O76064 O95714 O96028 P06899 P0CG47 P0CG48 P15927 P16104 P20248 P23527 P24941 P27694 P33778 P35244 P35249 P35250 P38398 P40937 P40938 P46736 P49959 P51530 P54132 P57053 P58876 P60510 P61088 P61956 P62805 P62807 P62979 P62987 P63279 P78317 P78396 Q12888 Q13315 Q13472 Q13535 Q14191 Q14676 Q15819 Q16695 Q16778 Q6UWZ7 Q6WBX8 Q8IYW5 Q8N257 Q8N2W9 Q8N6T7 Q8WXE1 Q92547 Q92878 Q92993 Q93079 Q96A08 Q96E14 Q96RL1 Q99638 Q99708 Q99728 Q99877 Q99879 Q99880 Q9BSD3 Q9BVW5 Q9BX63 Q9H9A7 Q9HAW4 Q9NWV8 Q9NXR7 Q9NY27 Q9UNS1 Q9UQ84	ABRA1 ABRAXAS1 AGS1 ATM ATR ATRIP BABAM1 BABAM2 BACH1 BARD1 BLM BLU BRCA1 BRCC3 BRCC36 BRCC45 BRE BRIP1 C12orf32 C16orf75 C19orf62 C6.1A C9orf76 CCDC98 CCN1 CCNA CCNA1 CCNA2 CDK2 CDKN2 CHEK1 CHK1 CLSPN CTIP CXorf53 DNA2 DNA2L EXO1 EXOI FAM175A FANCJ FRP1 H2AFX H2AX H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-4 H3FT H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HERC2 HEX1 HIRIP1 HIRIP2 HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2BE HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 HNGS1 HTATIP HUS1 KAT5 KIAA0083 KIAA0170 KIAA0259 KIAA0646 KIAA1090 MDC1 MERIT40 MMS2 MMSET MRE11 MRE11A NBA1 NBN NBS NBS1 NFBD1 NSD2 P95 PIAS4 PIASG PPP4 PPP4C PPP4R2 PPX R24L RAD1 RAD17 RAD50 RAD9A RAD9B RAP80 RBBP8 REC1 RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC2 RFC3 RFC4 RFC5 RHINO RHNO1 RMI1 RMI2 RNF168 RNF4 RNF53 RNF8 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A RXRIP110 SIR2L6 SIRT6 SMT3B SMT3H2 SNURF SUMO2 TIM TIM1 TIMELESS TIMELESS1 TIP60 TIPIN TOP3 TOP3A TOPBP1 TP53BP1 TRX5 TSH2B UBA52 UBA80 UBB UBC UBC9 UBCE9 UBCEP1 UBCEP2 UBE2I UBE2N UBE2V2 UEV2 UIMC1 WHSC1 WRN
Metalloprotease DUBs	26S proteasome non-ATPase regulatory subunit 14 AMSH-like protease BRCA1-A complex subunit Abraxas 1 BRCA1-A complex subunit RAP80 BRCA1-associated RING domain protein 1 BRISC and BRCA1-A complex member 1 BRISC and BRCA1-A complex member 2 BRISC complex subunit Abraxas 2 Breast cancer type 1 susceptibility protein Deubiquitinase MYSM1 Histone H2A type 1-A Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-H Histone H2A type 1-J Histone H2A type 1 Histone H2A type 2-A Histone H2A type 2-B Histone H2A type 2-C Histone H2A type 3 Histone acetyltransferase KAT2B Histone acetyltransferase p300 Lys-63-specific deubiquitinase BRCC36 NACHT, LRR and PYD domains-containing protein 3 Polyubiquitin-B Polyubiquitin-C STAM-binding protein Signal transducing adapter molecule 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00487 O95630 P04908 P0C0S8 P0CG47 P0CG48 P20671 P38398 P46736 P62979 P62987 Q09472 Q15018 Q16777 Q5VVJ2 Q6FI13 Q6UWZ7 Q7L7L0 Q8IUE6 Q92783 Q92831 Q93077 Q96FJ0 Q96KK5 Q96P20 Q96QV6 Q96RL1 Q99728 Q99878 Q9NWV8 Q9NXR7	ABRA1 ABRAXAS1 ABRAXAS2 ABRO1 AMSH AMSHLP BABAM1 BABAM2 BARD1 BRCA1 BRCC3 BRCC36 BRCC45 BRE C19orf62 C1orf7 C6.1A CCDC98 CIAS1 CXorf53 EP300 FAM175A FAM175B H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFC H2AFD H2AFE H2AFG H2AFI H2AFL H2AFM H2AFN H2AFO H2AFP H2AFQ H2AFR H2AW HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AG HIST1H2AH HIST1H2AI HIST1H2AJ HIST1H2AK HIST1H2AL HIST1H2AM HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AB HIST2H2AC HIST3H2A KAT2B KIAA0157 KIAA1373 KIAA1915 MERIT40 MYSM1 NALP3 NBA1 NLRP3 P300 PCAF POH1 PSMD14 PYPAF1 RAP80 RNF53 RPS27A RXRIP110 STAM STAM1 STAMBP STAMBPL1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UIMC1
CDC42 GTPase cycle	ADP-ribosylation factor GTPase-activating protein 2 ADP-ribosylation factor GTPase-activating protein 3 ARF GTPase-activating protein GIT1 ARF GTPase-activating protein GIT2 Actin nucleation-promoting factor WAS Actin nucleation-promoting factor WASL Active breakpoint cluster region-related protein Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 BAR/IMD domain-containing adapter protein 2 BTB/POZ domain-containing protein KCTD3 Breakpoint cluster region protein CDC42 small effector protein 2 Caveolin-1 Cdc42 effector protein 1 Cdc42 effector protein 2 Cdc42 effector protein 3 Cdc42 effector protein 4 Cdc42 effector protein 5 Cell division control protein 42 homolog Copine-8 DEP domain-containing protein 1B Dedicator of cytokinesis protein 10 Dedicator of cytokinesis protein 11 Dedicator of cytokinesis protein 6 Dedicator of cytokinesis protein 7 Dedicator of cytokinesis protein 8 Dedicator of cytokinesis protein 9 Delta(14)-sterol reductase LBR Differentially expressed in FDCP 6 homolog Disheveled-associated activator of morphogenesis 1 Dynamin-binding protein Ephexin-1 FERM, ARHGEF and pleckstrin domain-containing protein 1 FYVE, RhoGEF and PH domain-containing protein 1 FYVE, RhoGEF and PH domain-containing protein 2 FYVE, RhoGEF and PH domain-containing protein 3 FYVE, RhoGEF and PH domain-containing protein 4 Formin-binding protein 1-like Formin-binding protein 1 Formin-like protein 1 Formin-like protein 2 Formin-like protein 3 GEM-interacting protein Golgin subfamily A member 8R Guanine nucleotide exchange factor DBS Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Guanine nucleotide-binding protein subunit alpha-13 Inactive Rho GTPase-activating protein 11B Intersectin-1 Junction plakoglobin Kinectin Lamina-associated polypeptide 2, isoforms beta/gamma Metalloreductase STEAP3 Mitogen-activated protein kinase kinase kinase 11 N-chimaerin Oligophrenin-1 Partitioning defective 6 homolog alpha Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phospholipase D1 Pleckstrin homology domain-containing family G member 1 Pleckstrin homology domain-containing family G member 2 Pleckstrin homology domain-containing family G member 3 Pleckstrin homology domain-containing family G member 4B Protein ECT2 Protein FAM13B Protein diaphanous homolog 3 Protein scribble homolog Proto-oncogene DBL Puratrophin-1 Rac GTPase-activating protein 1 Ragulator complex protein LAMTOR1 RalA-binding protein 1 Ras GTPase-activating-like protein IQGAP1 Ras GTPase-activating-like protein IQGAP2 Ras GTPase-activating-like protein IQGAP3 Ras-related protein Rab-7a Ras-specific guanine nucleotide-releasing factor 2 Rho GDP-dissociation inhibitor 1 Rho GDP-dissociation inhibitor 2 Rho GDP-dissociation inhibitor 3 Rho GTPase-activating protein 10 Rho GTPase-activating protein 17 Rho GTPase-activating protein 1 Rho GTPase-activating protein 20 Rho GTPase-activating protein 21 Rho GTPase-activating protein 22 Rho GTPase-activating protein 24 Rho GTPase-activating protein 26 Rho GTPase-activating protein 27 Rho GTPase-activating protein 29 Rho GTPase-activating protein 30 Rho GTPase-activating protein 31 Rho GTPase-activating protein 32 Rho GTPase-activating protein 33 Rho GTPase-activating protein 35 Rho GTPase-activating protein 39 Rho GTPase-activating protein 40 Rho GTPase-activating protein 42 Rho GTPase-activating protein 44 Rho GTPase-activating protein 45 Rho GTPase-activating protein 4 Rho GTPase-activating protein 5 Rho GTPase-activating protein 7 Rho GTPase-activating protein 9 Rho GTPase-activating protein SYDE1 Rho guanine nucleotide exchange factor 10 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 12 Rho guanine nucleotide exchange factor 15 Rho guanine nucleotide exchange factor 16 Rho guanine nucleotide exchange factor 19 Rho guanine nucleotide exchange factor 25 Rho guanine nucleotide exchange factor 26 Rho guanine nucleotide exchange factor 4 Rho guanine nucleotide exchange factor 5 Rho guanine nucleotide exchange factor 6 Rho guanine nucleotide exchange factor 7 Rho guanine nucleotide exchange factor 9 Rho guanine nucleotide exchange factor TIAM1 SH3 and PX domain-containing protein 2A SH3KBP1-binding protein 1 SLIT-ROBO Rho GTPase-activating protein 1 SLIT-ROBO Rho GTPase-activating protein 2 SLIT-ROBO Rho GTPase-activating protein 3 Serine/threonine-protein kinase MRCK alpha Serine/threonine-protein kinase MRCK beta Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase PAK 4 Serine/threonine-protein kinase PAK 5 Serine/threonine-protein kinase PAK 6 Spermatogenesis-associated protein 13 StAR-related lipid transfer protein 13 StAR-related lipid transfer protein 8 Stomatin Synaptobrevin homolog YKT6 Synaptosomal-associated protein 23 T-cell activation Rho GTPase-activating protein Transferrin receptor protein 1 Triple functional domain protein Unconventional myosin-IXb Vang-like protein 1 Vesicle-associated membrane protein 3 WAS/WASL-interacting protein family member 1 WAS/WASL-interacting protein family member 2 WAS/WASL-interacting protein family member 3 WD repeat-containing protein 81 WD repeat-containing protein 91	A1A4S6 A1L390 A4D1P6 A6NGB9 A6NI28 A7KAX9 I6L899 O00161 O00401 O00459 O14559 O14613 O14827 O15013 O15068 O15085 O15498 O43295 O43307 O43516 O60890 O75044 O75914 O75962 O94989 O95466 O96013 P02786 P10911 P11274 P14923 P15882 P27105 P27986 P42167 P42768 P46940 P51149 P52565 P52566 P52735 P60953 P98171 P98174 Q00587 Q03135 Q07960 Q12774 Q12979 Q13009 Q13017 Q13153 Q13177 Q13393 Q13459 Q13576 Q14155 Q14160 Q14161 Q14344 Q14739 Q15052 Q15311 Q15811 Q15836 Q16584 Q17R89 Q2M1Z3 Q3KRB8 Q52LW3 Q562E7 Q58EX7 Q5JSL3 Q5JSP0 Q5T0N5 Q5T5U3 Q5TCZ1 Q5TG30 Q5VT25 Q5VV41 Q658P3 Q68EM7 Q6IAA8 Q6NZY7 Q6XZF7 Q6ZUM4 Q6ZW31 Q70Z35 Q7Z5H3 Q7Z6B7 Q7Z6I6 Q7Z6J4 Q86UP2 Q86VI3 Q86VW2 Q86YQ8 Q8IVF7 Q8IW93 Q8N103 Q8N264 Q8N5V2 Q8N6H7 Q8NF50 Q8TAA9 Q8TBC3 Q8TCU6 Q8TF74 Q8WUY9 Q8WWN8 Q8WZ64 Q92502 Q92619 Q96BY6 Q96DR7 Q96HP0 Q96M96 Q96N67 Q96N96 Q96P48 Q96PX9 Q96PY5 Q96QB1 Q96RU3 Q99819 Q9BRR9 Q9BZ29 Q9C0H5 Q9H0H5 Q9H3Q1 Q9H4E7 Q9H7P9 Q9H8V3 Q9NP61 Q9NPB6 Q9NQU5 Q9NR80 Q9NRR3 Q9NRY4 Q9NSV4 Q9NYF5 Q9NZN5 Q9P107 Q9P286 Q9P2F6 Q9UKI2 Q9UKW4 Q9ULL1 Q9UNA1 Q9UQB8 Q9Y2X7 Q9Y3M8 Q9Y4D1 Q9Y4F1 Q9Y597 Q9Y5S2	ABR ARAP1 ARAP2 ARAP3 ARFGAP1 ARFGAP2 ARFGAP3 ARHDH9 ARHGAP1 ARHGAP10 ARHGAP11B ARHGAP13 ARHGAP14 ARHGAP17 ARHGAP2 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP24 ARHGAP26 ARHGAP27 ARHGAP29 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP34 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP40 ARHGAP42 ARHGAP44 ARHGAP45 ARHGAP5 ARHGAP7 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF19 ARHGEF25 ARHGEF26 ARHGEF36 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 BAIAP2 BCR BCR1 BND7 BORG1 BORG2 BORG3 BORG4 BORG5 C11orf59 C17orf1 C17orf1B C1orf39 C20orf95 C5orf5 CAMGAP1 CAV CAV1 CDC42 CDC42BPA CDC42BPB CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42GAP CDC42SE2 CDEP CDGAP CENTD1 CENTD2 CENTD3 CEP1 CEP2 CEP3 CEP4 CEP5 CG1 CHN CHN1 COOL1 COOL2 CPNE8 CR16 CRIB1 CTNNG D22S11 DAAM1 DBL DEF6 DEPDC1B DEPDC2 DIAP3 DIAPH3 DLC1 DLC2 DLC3 DNMBP DOCK10 DOCK11 DOCK6 DOCK7 DOCK8 DOCK9 DP3 ECT2 EPB72 EPHEXIN4 FAM13B FAM13B1 FAM7B1 FARP1 FBP17 FGD1 FGD2 FGD3 FGD4 FGDY FHOD2 FHOD3 FILGAP FISH FMNL FMNL1 FMNL2 FMNL3 FNBP1 FNBP1L FNBP2 FRABP FRL1 FRL2 GDIA1 GDIA2 GDID4 GEFT GIT1 GIT2 GMIP GNA13 GOLGA8R GRAF GRAF2 GRAF3 GRB1 GRF1 GRF2 GRIT GRLF1 GT650 HMHA1 IBP IMD2 IQGAP1 IQGAP2 IQGAP3 ITSN ITSN1 JUP KCTD3 KIAA0004 KIAA0006 KIAA0051 KIAA0131 KIAA0142 KIAA0147 KIAA0148 KIAA0189 KIAA0223 KIAA0294 KIAA0362 KIAA0380 KIAA0382 KIAA0411 KIAA0418 KIAA0424 KIAA0451 KIAA0456 KIAA0554 KIAA0580 KIAA0599 KIAA0621 KIAA0666 KIAA0672 KIAA0694 KIAA0712 KIAA0782 KIAA0915 KIAA1010 KIAA1058 KIAA1112 KIAA1124 KIAA1142 KIAA1156 KIAA1204 KIAA1209 KIAA1264 KIAA1304 KIAA1391 KIAA1395 KIAA1415 KIAA1424 KIAA1478 KIAA1688 KIAA1722 KIAA1723 KIAA1771 KIAA1902 KIAA1909 KIAA2014 KTN1 LAMTOR1 LAP2 LAP4 LARG LBR MAP3K11 MCF2 MCF2L MEGAP MGCRACGAP MLK3 MSE55 MYO9B MYR5 NBR NGEF OPHN1 OPHN1L OPHN3 OST P190A P85SPR PAK1 PAK2 PAK3 PAK3BP PAK4 PAK5 PAK6 PAK7 PAR6A PARD6A PARG1 PDRO PIK3R1 PIK3R2 PIXA PIXB PLD1 PLEKHC2 PLEKHG1 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHG4B PREX1 PREX2 PRTPHN1 PTK1 RAB7 RAB7A RACGAP1 RALBP1 RAP1GN1 RASGRF2 RGC1 RHOGAP1 RHOGAP2 RHOGAP4 RHOGAP5 RICH1 RICH2 RICS RLIP RLIP1 RLIP76 SB1 SCRB1 SCRIB SGEF SH3D1A SH3D20 SH3MD1 SH3PXD2A SHKBP1 SNAP23 SNX26 SPATA13 SPEC2 SPRK SRGAP1 SRGAP2 SRGAP2A SRGAP3 STARD12 STARD13 STARD8 STB2 STEAP3 STOM SYB3 SYDE1 TAGAP TAGAP1 TCGAP TFRC TIAM1 TIM TKS5 TMEM133 TMPO TOCA1 TRIO TSAP6 TUBA VAMP3 VANGL1 VARTUL VAV2 VAV3 WAS WASL WASPIP WBP3 WDR81 WDR91 WICH WIP WIPF1 WIPF2 WIPF3 WIRE XTP8 YKT6 ZFYVE3 ZFYVE4 ZFYVE5 ZFYVE6 ZIZ1 ZIZ2 ZIZ3 ZNF289 p190ARHOGAP
G alpha (12/13) signalling events	A-kinase anchor protein 13 Active breakpoint cluster region-related protein Alpha-1A adrenergic receptor Alpha-1B adrenergic receptor Alpha-1D adrenergic receptor Ephexin-1 FYVE, RhoGEF and PH domain-containing protein 1 FYVE, RhoGEF and PH domain-containing protein 2 FYVE, RhoGEF and PH domain-containing protein 3 FYVE, RhoGEF and PH domain-containing protein 4 Guanine nucleotide exchange factor DBS Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein subunit alpha-12 Guanine nucleotide-binding protein subunit alpha-13 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Intersectin-1 Kalirin Neuroepithelial cell-transforming gene 1 protein Obscurin Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Pleckstrin homology domain-containing family G member 2 Pleckstrin homology domain-containing family G member 5 Plexin-B1 Protein ECT2 Proto-oncogene DBL Proto-oncogene vav Ras-specific guanine nucleotide-releasing factor 2 Rho guanine nucleotide exchange factor 10-like protein Rho guanine nucleotide exchange factor 10 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 12 Rho guanine nucleotide exchange factor 15 Rho guanine nucleotide exchange factor 16 Rho guanine nucleotide exchange factor 17 Rho guanine nucleotide exchange factor 18 Rho guanine nucleotide exchange factor 19 Rho guanine nucleotide exchange factor 1 Rho guanine nucleotide exchange factor 26 Rho guanine nucleotide exchange factor 2 Rho guanine nucleotide exchange factor 33 Rho guanine nucleotide exchange factor 35 Rho guanine nucleotide exchange factor 37 Rho guanine nucleotide exchange factor 38 Rho guanine nucleotide exchange factor 39 Rho guanine nucleotide exchange factor 3 Rho guanine nucleotide exchange factor 40 Rho guanine nucleotide exchange factor 4 Rho guanine nucleotide exchange factor 5 Rho guanine nucleotide exchange factor 6 Rho guanine nucleotide exchange factor 7 Rho guanine nucleotide exchange factor 9 Rho guanine nucleotide exchange factor TIAM1 Rho guanine nucleotide exchange factor TIAM2 Rho-associated protein kinase 1 Rho-associated protein kinase 2 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoC Son of sevenless homolog 1 Son of sevenless homolog 2 Thromboxane A2 receptor Transforming protein RhoA Triple functional domain protein Tyrosine-protein kinase BTK	A1IGU5 A5YM69 A8MVX0 O14610 O14775 O14827 O15013 O15068 O15085 O43157 O43307 O60229 O60262 O75116 O75962 O94827 O94989 P08134 P10911 P15498 P16520 P21731 P25100 P35348 P35368 P50150 P50151 P52735 P59768 P61586 P61952 P62745 P62873 P62879 P63211 P63215 P63218 P98174 Q03113 Q06187 Q07889 Q07890 Q12774 Q12802 Q12979 Q13009 Q13464 Q14155 Q14344 Q15052 Q15811 Q5JSP0 Q5VST9 Q5VV41 Q6ZSZ5 Q7Z628 Q7Z6J4 Q8IVF5 Q8IW93 Q8N4T4 Q8N5V2 Q8TCU6 Q8TER5 Q92888 Q92974 Q96DR7 Q96M96 Q96PE2 Q9H7P9 Q9H8V3 Q9HAV0 Q9HCE6 Q9NR80 Q9NR81 Q9NXL2 Q9NZN5 Q9P2W3 Q9UBI6 Q9UK08 Q9UKW4	ABR ADRA1A ADRA1B ADRA1C ADRA1D AGMX1 AKAP13 ARH12 ARH6 ARH9 ARHA ARHB ARHC ARHDH9 ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF26 ARHGEF3 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF5L ARHGEF6 ARHGEF7 ARHGEF8 ARHGEF9 ATK BPK BRX BTK C9orf100 COOL1 COOL2 DBL DUET DUO ECT2 EPHEXIN4 FGD1 FGD2 FGD3 FGD4 FGDY FRABP GNA12 GNA13 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 GRF2 GRINCHGEF HAPIP HT31 ITSN ITSN1 KALRN KIAA0006 KIAA0142 KIAA0294 KIAA0337 KIAA0362 KIAA0380 KIAA0382 KIAA0407 KIAA0424 KIAA0521 KIAA0619 KIAA0651 KIAA0720 KIAA0915 KIAA1112 KIAA1415 KIAA1556 KIAA1626 KIAA1639 KIAA2016 LARG LBC LFP40 MCF2 MCF2L NBR NET1 NGEF OBSCN OST P85SPR PAK3BP PIXA PIXB PLEKHG2 PLEKHG5 PLXN5 PLXNB1 PREX1 RASGRF2 RHO12 RHOA RHOB RHOC ROCK1 ROCK2 SEP SGEF SH3D1A SOLO SOS1 SOS2 STEF TBXA2R TEM4 TIAM1 TIAM2 TIM TRAD TRIO VAV VAV1 VAV2 VAV3 ZFYVE3 ZFYVE4 ZFYVE5 ZFYVE6
RHOB GTPase cycle	A-kinase anchor protein 13 Actin, alpha cardiac muscle 1 Active breakpoint cluster region-related protein Anillin Ankyrin repeat domain-containing protein SOWAHC Breakpoint cluster region protein Caveolae-associated protein 1 Caveolin-1 Cell surface glycoprotein MUC18 Citron Rho-interacting kinase DEP domain-containing protein 1B Disheveled-associated activator of morphogenesis 1 Erbin Flotillin-1 Flotillin-2 Guanine nucleotide exchange factor DBS Guanine nucleotide exchange factor VAV2 Junction plakoglobin Neuroepithelial cell-transforming gene 1 protein Oligophrenin-1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Protein ECT2 Protein diaphanous homolog 1 Protein diaphanous homolog 3 Proto-oncogene DBL Protocadherin-7 Rac GTPase-activating protein 1 Ras GTPase-activating-like protein IQGAP3 Rho GDP-dissociation inhibitor 3 Rho GTPase-activating protein 1 Rho GTPase-activating protein 21 Rho GTPase-activating protein 26 Rho GTPase-activating protein 32 Rho GTPase-activating protein 35 Rho GTPase-activating protein 39 Rho GTPase-activating protein 5 Rho GTPase-activating protein 7 Rho guanine nucleotide exchange factor 10-like protein Rho guanine nucleotide exchange factor 10 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 12 Rho guanine nucleotide exchange factor 17 Rho guanine nucleotide exchange factor 1 Rho guanine nucleotide exchange factor 25 Rho guanine nucleotide exchange factor 28 Rho guanine nucleotide exchange factor 2 Rho guanine nucleotide exchange factor 3 Rho guanine nucleotide exchange factor 5 Rho-associated protein kinase 1 Rho-associated protein kinase 2 Rho-related GTP-binding protein RhoB Rhophilin-2 Rhotekin STE20-like serine/threonine-protein kinase Serine/threonine-protein kinase 10 Serine/threonine-protein kinase N1 Serine/threonine-protein kinase N2 Serine/threonine-protein kinase N3 StAR-related lipid transfer protein 13 StAR-related lipid transfer protein 8 Stomatin Synaptosomal-associated protein 23 Tight junction protein ZO-2 Transferrin receptor protein 1 Unconventional myosin-IXa Unconventional myosin-IXb Vang-like protein 1 Vesicle-associated membrane protein 3	A7KAX9 B2RTY4 O00161 O00459 O14578 O15013 O15068 O15085 O60245 O60610 O60890 O75116 O75955 O94804 P02786 P10911 P11274 P14923 P27105 P27986 P43121 P52735 P62745 P68032 Q03135 Q07960 Q12774 Q12802 Q12979 Q13017 Q13459 Q13464 Q14254 Q15836 Q16512 Q16513 Q53LP3 Q5T5U3 Q6NZI2 Q6P5Z2 Q7Z628 Q86VI3 Q86VW2 Q8IUC4 Q8N1W1 Q8TAA9 Q8TCU6 Q8WUY9 Q92502 Q92888 Q92974 Q96PE2 Q96QB1 Q96RT1 Q99819 Q9BST9 Q9C0H5 Q9H0H5 Q9H2G2 Q9H8V3 Q9HCE6 Q9NQW6 Q9NR81 Q9NRY4 Q9NSV4 Q9NZN5 Q9UDY2 Q9UNA1 Q9Y3M8 Q9Y4D1	ABR ACTC ACTC1 AKAP13 ANKRD57 ANLN ARH6 ARHB ARHGAP1 ARHGAP10 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP5 ARHGAP7 ARHGDIG ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF17 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF5 ARHGEF8 BCR BCR1 BHPCDH BND7 BRX C2orf26 CAV CAV1 CAVIN1 CDC42GAP CIT CRIK CTNNG D22S11 DAAM1 DBL DEPDC1B DIAP1 DIAP3 DIAPH1 DIAPH3 DLC1 DLC2 DLC3 DP3 ECT2 EPB72 ERBB2IP ERBIN ESA1 FLOT1 FLOT2 GEFT GRAF GRB1 GRF1 GRINCHGEF GRIT GRLF1 GT650 HT31 IQGAP3 JUP KIAA0189 KIAA0204 KIAA0294 KIAA0337 KIAA0362 KIAA0380 KIAA0382 KIAA0619 KIAA0621 KIAA0651 KIAA0666 KIAA0712 KIAA0949 KIAA1225 KIAA1415 KIAA1424 KIAA1478 KIAA1626 KIAA1688 KIAA1722 KIAA1723 KIAA1998 LAP2 LARG LBC LFP40 LOK M17S1 MCAM MCF2 MCF2L MGCRACGAP MUC18 MYO9A MYO9B MYR5 MYR7 NET1 OPHN1 OPHN1L OST P190A PAK1 PCDH7 PIK3R1 PIK3R2 PKN PKN1 PKN2 PKN3 PKNBETA PREX1 PRK1 PRK2 PRKCL1 PRKCL2 PTRF RACGAP1 RGNEF RHOB RHOGAP1 RHOGAP5 RHPN2 RICS ROCK1 ROCK2 RTKN RTKN1 SLK SNAP23 SOWAHC STARD12 STARD13 STARD8 STB2 STK10 STK2 STK21 STOM SYB3 TEM4 TFRC TIM TJP2 VAMP3 VANGL1 VAV2 X104 XTP8 ZO2 p190ARHOGAP
Cell-extracellular matrix interactions	Alpha-parvin Beta-parvin Fermitin family homolog 2 Filamin-A Filamin-C Filamin-binding LIM protein 1 Integrin-linked protein kinase LIM and senescent cell antigen-like-containing domain protein 1 LIM and senescent cell antigen-like-containing domain protein 2 Vasodilator-stimulated phosphoprotein	P21333 P48059 P50552 Q13418 Q14315 Q7Z4I7 Q8WUP2 Q96AC1 Q9HBI1 Q9NVD7	ABPL FBLIM1 FBLP1 FERMT2 FLN FLN1 FLN2 FLNA FLNC ILK ILK1 ILK2 KIND2 LIMS1 LIMS2 MIG2 MXRA2 PARVA PARVB PINCH PINCH1 PINCH2 PLEKHC1 VASP
ABO blood group biosynthesis	Galactoside alpha-(1,2)-fucosyltransferase 1 Galactoside alpha-(1,2)-fucosyltransferase 2 Histo-blood group ABO system transferase	P16442 P19526 Q10981	ABO FUT1 FUT2 H HSC SEC2
DCC mediated attractive signaling	Actin nucleation-promoting factor WASL Actin-binding LIM protein 1 Actin-binding LIM protein 2 Actin-binding LIM protein 3 Cell division control protein 42 homolog Dedicator of cytokinesis protein 1 Focal adhesion kinase 1 Netrin receptor DCC Netrin-1 Proto-oncogene tyrosine-protein kinase Src Ras-related C3 botulinum toxin substrate 1 SH2/SH3 adapter protein NCK1 Triple functional domain protein	O00401 O14639 O75962 O94929 O95631 P12931 P16333 P43146 P60953 P63000 Q05397 Q14185 Q6H8Q1	ABLIM ABLIM1 ABLIM2 ABLIM3 CDC42 DCC DOCK1 FAK FAK1 IGDCC1 KIAA0059 KIAA0843 KIAA1808 LIMAB1 NCK NCK1 NTN1 NTN1L PTK2 RAC1 SRC SRC1 TC25 TRIO WASL
Negative regulation of FLT3	E3 ubiquitin-protein ligase CBL Fms-related tyrosine kinase 3 ligand Polyubiquitin-B Polyubiquitin-C Receptor-type tyrosine-protein kinase FLT3 Receptor-type tyrosine-protein phosphatase eta SH2B adapter protein 3 Src-like-adapter 2 Src-like-adapter Suppressor of cytokine signaling 2 Suppressor of cytokine signaling 6 Tyrosine-protein kinase ABL2 Tyrosine-protein kinase CSK Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14508 O14544 P0CG47 P0CG48 P22681 P36888 P41240 P42684 P49771 P62979 P62987 Q12913 Q13239 Q9H6Q3 Q9UQQ2	ABL2 ABLL ARG C20orf156 CBL CBL2 CD135 CIS2 CIS4 CSK DEP1 FLK2 FLT3 FLT3LG LNK PTPRJ RNF55 RPS27A SH2B3 SLA SLA2 SLAP SLAP1 SLAP2 SOCS2 SOCS4 SOCS6 SSI2 STATI2 STK1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
Myogenesis	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 C-Jun-amino-terminal kinase-interacting protein 4 Cadherin-15 Cadherin-2 Cadherin-4 Catenin alpha-1 Catenin alpha-2 Catenin beta-1 Cell adhesion molecule-related/down-regulated by oncogenes Cell division control protein 42 homolog Dual specificity mitogen-activated protein kinase kinase 6 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 14 Myoblast determination protein 1 Myocyte-specific enhancer factor 2A Myocyte-specific enhancer factor 2B Myocyte-specific enhancer factor 2C Myocyte-specific enhancer factor 2D Myogenic factor 5 Myogenic factor 6 Myogenin Neogenin Netrin-3 Transcription factor 12 Transcription factor 4 Transcription factor E2-alpha Tyrosine-protein kinase ABL1	O00634 O60271 P00519 P13349 P15172 P15173 P15884 P15923 P19022 P23409 P26232 P35221 P35222 P52564 P53778 P55283 P55291 P60953 Q02078 Q02080 Q06413 Q12982 Q14814 Q15759 Q16539 Q4KMG0 Q92859 Q99081	ABL ABL1 BHLHB19 BHLHB20 BHLHB21 BHLHC1 BHLHC2 BHLHC3 BHLHC4 BNIP2 CAPR CDC42 CDH14 CDH15 CDH2 CDH3 CDH4 CDHN CDO CDON CSBP CSBP1 CSBP2 CSPB1 CTNNA1 CTNNA2 CTNNB CTNNB1 E2A ERK6 HEB HSS HTF4 IGDCC2 ITF1 ITF2 JTK7 KIAA0516 MAP2K6 MAPK11 MAPK12 MAPK14 MAPK8IP4 MEF2 MEF2A MEF2B MEF2C MEF2D MEK6 MKK6 MRF4 MXI2 MYF3 MYF4 MYF5 MYF6 MYOD MYOD1 MYOG NCAD NEO1 NGN NIP2 NTN2L NTN3 PRKM11 PRKMK6 SAPK2 SAPK2A SAPK2B SAPK3 SEF2 SKK3 SPAG9 SYD1 TCF12 TCF3 TCF4 XMEF2
Cyclin D associated events in G1	CDK-activating kinase assembly factor MAT1 Cullin-1 Cyclin-H Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 inhibitor B Cyclin-dependent kinase 4 inhibitor C Cyclin-dependent kinase 4 inhibitor D Cyclin-dependent kinase 4 Cyclin-dependent kinase 6 Cyclin-dependent kinase 7 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase inhibitor 1C Cyclin-dependent kinase inhibitor 2A Cyclin-dependent kinases regulatory subunit 1 G1/S-specific cyclin-D1 G1/S-specific cyclin-D2 G1/S-specific cyclin-D3 G1/S-specific cyclin-E1 G1/S-specific cyclin-E2 Polyubiquitin-B Polyubiquitin-C Protein-tyrosine kinase 6 Retinoblastoma-associated protein Retinoblastoma-like protein 1 Retinoblastoma-like protein 2 S-phase kinase-associated protein 1 S-phase kinase-associated protein 2 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F2 Transcription factor E2F3 Transcription factor E2F4 Transcription factor E2F5 Tyrosine-protein kinase ABL1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00716 O60674 O96020 P00519 P06400 P07948 P0CG47 P0CG48 P11802 P24385 P24864 P24941 P28749 P30153 P30154 P30279 P30281 P38936 P42771 P42772 P42773 P46527 P49918 P50613 P51946 P51948 P55273 P61024 P62714 P62979 P62987 P63151 P63208 P67775 Q00534 Q01094 Q08999 Q13309 Q13616 Q13882 Q14186 Q14188 Q14209 Q15329 Q16254 Q9Y5P8	ABL ABL1 BCL1 BRK CAK CAK1 CAP20 CAP35 CCND1 CCND2 CCND3 CCNE CCNE1 CCNE2 CCNH CDK2 CDK4 CDK6 CDK7 CDKN1 CDKN1A CDKN1B CDKN1C CDKN2 CDKN2A CDKN2B CDKN2C CDKN2D CDKN6 CDKN7 CIP1 CKS1 CKS1B CUL1 DP1 DP2 E2F1 E2F2 E2F3 E2F4 E2F5 EMC19 FBXL1 JAK2 JTK7 JTK8 KIAA0075 KIP1 KIP2 LYN MAT1 MDA6 MNAT1 MO15 MTS1 MTS2 OCP2 PIC1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R3B PPP2R3L PRAD1 PTK6 RB1 RB2 RBBP3 RBL1 RBL2 RNF66 RPS27A SDI1 SKP1 SKP1A SKP2 STK1 TCEB1L TFDP1 TFDP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WAF1 p27

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