GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **1001 - 1025** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
ADP signalling through P2Y purinoceptor 1	Cytosolic phospholipase A2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(q) subunit alpha Guanine nucleotide-binding protein subunit alpha-11 Guanine nucleotide-binding protein subunit alpha-14 Guanine nucleotide-binding protein subunit alpha-15 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Mitogen-activated protein kinase 14 P2Y purinoceptor 1	O14610 O14775 O60262 O95837 P16520 P29992 P30679 P47712 P47900 P50148 P50150 P50151 P59768 P61952 P62873 P62879 P63211 P63215 P63218 Q16539 Q9HAV0 Q9P2W3 Q9UBI6 Q9UK08	CPLA2 CSBP CSBP1 CSBP2 CSPB1 GA11 GAQ GNA11 GNA14 GNA15 GNA16 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 MAPK14 MXI2 P2RY1 PLA2G4 PLA2G4A SAPK2A	Homo sapiens (human)
rRNA modification in the nucleus and cytosol	18S rRNA (guanine-N(7))-methyltransferase 18S rRNA aminocarboxypropyltransferase 28S rRNA (cytosine(4447)-C(5))-methyltransferase DDB1- and CUL4-associated factor 13 Dimethyladenosine transferase H/ACA ribonucleoprotein complex subunit 1 H/ACA ribonucleoprotein complex subunit 2 H/ACA ribonucleoprotein complex subunit 3 H/ACA ribonucleoprotein complex subunit DKC1 HEAT repeat-containing protein 1 KRR1 small subunit processome component homolog Multifunctional methyltransferase subunit TRM112-like protein NHP2-like protein 1 Nucleolar complex protein 4 homolog Nucleolar protein 11 Nucleolar protein 14 Nucleolar protein 56 Nucleolar protein 58 Nucleolar protein 6 Periodic tryptophan protein 2 homolog Probable ATP-dependent RNA helicase DDX47 Probable ATP-dependent RNA helicase DDX49 Probable ATP-dependent RNA helicase DDX52 Probable ATP-dependent RNA helicase DHX37 Probable U3 small nucleolar RNA-associated protein 11 Protein RRP5 homolog RNA 3'-terminal phosphate cyclase-like protein RNA cytidine acetyltransferase RNA-binding protein PNO1 Ribosomal RNA processing protein 36 homolog Ribosomal RNA small subunit methyltransferase NEP1 Ribosomal RNA-processing protein 7 homolog A Ribosome biogenesis protein BMS1 homolog Small ribosomal subunit protein eS6 Small ribosomal subunit protein eS7 Small ribosomal subunit protein uS11 Small ribosomal subunit protein uS4 Small ribosomal subunit protein uS5 Small subunit processome component 20 homolog Something about silencing protein 10 THUMP domain-containing protein 1 Transducin beta-like protein 3 U3 small nucleolar RNA-associated protein 14 homolog A U3 small nucleolar RNA-associated protein 14 homolog C U3 small nucleolar RNA-associated protein 15 homolog U3 small nucleolar RNA-associated protein 18 homolog U3 small nucleolar RNA-associated protein 25 homolog U3 small nucleolar RNA-associated protein 4 homolog U3 small nucleolar RNA-associated protein 6 homolog U3 small nucleolar RNA-interacting protein 2 U3 small nucleolar ribonucleoprotein protein IMP3 U3 small nucleolar ribonucleoprotein protein IMP4 U3 small nucleolar ribonucleoprotein protein MPP10 WD repeat-containing protein 36 WD repeat-containing protein 3 WD repeat-containing protein 43 WD repeat-containing protein 46 WD repeat-containing protein 75 rRNA 2'-O-methyltransferase fibrillarin rRNA-processing protein FCF1 homolog	O00566 O00567 O15213 O43709 O43818 O60832 O75691 P15880 P22087 P46087 P46781 P55769 P62081 P62263 P62753 P78316 Q12788 Q13601 Q14690 Q14692 Q15061 Q15269 Q5TAP6 Q68CQ4 Q8IWA0 Q8IY37 Q8NI36 Q8TED0 Q92979 Q969X6 Q96EU6 Q96G21 Q9BVI4 Q9BVJ6 Q9H0A0 Q9H0S4 Q9H583 Q9H6R4 Q9H8H0 Q9NPE3 Q9NQZ2 Q9NRX1 Q9NV06 Q9NV31 Q9NX24 Q9NXG2 Q9NY12 Q9NYH9 Q9UI30 Q9UJK0 Q9UNQ2 Q9UNX4 Q9Y2P8 Q9Y2R4 Q9Y2X3 Q9Y324 Q9Y3A2 Q9Y3A4 Q9Y5J1 Q9Y6V7	ALP BAP28 BING4 BMS1 BMS1L BUD23 BXDC4 C14orf111 C15orf12 C16orf42 C17orf40 C1orf107 C2F C4orf9 C6orf11 C6orf153 CIRH1A CRLZ1 DCAF13 DDX37 DDX47 DDX49 DDX52 DEF DHX37 DIEXF DIMT1 DIMT1L DKC1 DRIM EMG1 FBL FCF1 FIB1 FLRN GAR1 HCA66 HEATR1 HRB2 IMP3 IMP4 KIAA0007 KIAA0185 KIAA0187 KIAA0266 KIAA1517 KIAA1709 KIAA1988 KRR1 MERM1 MHAT MPHOSPH10 MPP10 MRPS4 NAT10 NHP2 NHP2L1 NOC4L NOL1 NOL11 NOL14 NOL5 NOL5A NOL6 NOLA1 NOLA2 NOLA3 NOLA4 NOP10 NOP14 NOP2 NOP5 NOP56 NOP58 NSUN1 PDCD11 PNO1 PWP2 PWP2H RCL1 RNAC RNU3IP2 ROK1 RPC2 RPCL1 RPS14 RPS2 RPS4 RPS6 RPS7 RPS9 RRP36 RRP7A RRP9 RTC2 SAS10 SAZD SDCCAG16 SNU13 TBL3 THUMPD1 TRMT112 TSR3 U355K UND313L UTP10 UTP11 UTP11L UTP14A UTP14C UTP15 UTP17 UTP18 UTP20 UTP25 UTP3 UTP4 UTP5 UTP6 WBSCR22 WDR3 WDR36 WDR43 WDR46 WDR50 WDR75 WDSOF1 cPERP-E	Homo sapiens (human)
Cytosolic sensors of pathogen-associated DNA	DNA-dependent protein kinase catalytic subunit DNA-directed RNA polymerase III subunit RPC10 DNA-directed RNA polymerase III subunit RPC1 DNA-directed RNA polymerase III subunit RPC2 DNA-directed RNA polymerase III subunit RPC3 DNA-directed RNA polymerase III subunit RPC4 DNA-directed RNA polymerase III subunit RPC5 DNA-directed RNA polymerase III subunit RPC6 DNA-directed RNA polymerase III subunit RPC7-like DNA-directed RNA polymerase III subunit RPC7 DNA-directed RNA polymerase III subunit RPC8 DNA-directed RNA polymerase III subunit RPC9 DNA-directed RNA polymerases I and III subunit RPAC1 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Double-strand break repair protein MRE11 Interferon-inducible protein AIM2 Protein POLR1D, isoform 2 X-ray repair cross-complementing protein 5 X-ray repair cross-complementing protein 6	O14802 O14862 O15160 O15318 O75575 P05423 P0DPB5 P12956 P13010 P19388 P49959 P52434 P53803 P61218 P62875 P78527 Q9BT43 Q9BUI4 Q9H1D9 Q9NVU0 Q9NW08 Q9Y2Y1 Q9Y535	AIM2 BN51 BN51T CRCP G22P1 G22P2 HNGS1 HYRC HYRC1 KIAA1452 KIAA1665 MRE11 MRE11A POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POLRF PRKDC RPC11 RPC8 XRCC5 XRCC6	Homo sapiens (human)
Binding of TCF/LEF:CTNNB1 to target gene promoters	Axin-2 Catenin beta-1 Lymphoid enhancer-binding factor 1 Myc proto-oncogene protein Runt-related transcription factor 3 Transcription factor 7-like 1 Transcription factor 7-like 2 Transcription factor 7	P01106 P35222 P36402 Q13761 Q9HCS4 Q9NQB0 Q9UJU2 Q9Y2T1	AML2 AXIN2 BHLHE39 CBFA3 CTNNB CTNNB1 LEF1 MYC PEBP2A3 RUNX3 TCF1 TCF3 TCF4 TCF7 TCF7L1 TCF7L2	Homo sapiens (human)
Synthesis of IPs in the ER lumen	Multiple inositol polyphosphate phosphatase 1	Q9UNW1	MINPP1 MIPP	Homo sapiens (human)
Erythrocytes take up carbon dioxide and release oxygen	Ammonium transporter Rh type A Aquaporin-1 Band 3 anion transport protein Carbonic anhydrase 1 Carbonic anhydrase 2 Carbonic anhydrase 4 Cytochrome b5 reductase 4 Hemoglobin subunit alpha Hemoglobin subunit beta NADH-cytochrome b5 reductase 1 NADH-cytochrome b5 reductase 2 NADH-cytochrome b5 reductase-like	P00915 P00918 P02730 P22748 P29972 P68871 P69905 Q02094 Q6BCY4 Q6IPT4 Q7L1T6 Q9UHQ9	AE1 AQP1 CA1 CA2 CA4 CHIP28 CYB5R1 CYB5R2 CYB5R4 CYB5RL DI EPB3 HBA1 HBA2 HBB NCB5OR NQO3A2 RH50 RHAG SLC4A1	Homo sapiens (human)
Mitochondrial unfolded protein response (UPRmt)	10 kDa heat shock protein, mitochondrial 60 kDa heat shock protein, mitochondrial Catalase Cyclic AMP-dependent transcription factor ATF-5 Defensin alpha 5 DnaJ homolog subfamily A member 1 Estrogen receptor Forkhead box protein O3 Heat shock 70 kDa protein 1A Heat shock 70 kDa protein 1B Heat shock factor protein 1 Lon protease homolog, mitochondrial NAD-dependent protein deacetylase sirtuin-3, mitochondrial Nuclear respiratory factor 1 RAC-alpha serine/threonine-protein kinase Serine protease HTRA2, mitochondrial Stress-70 protein, mitochondrial Superoxide dismutase [Mn], mitochondrial	O43464 O43524 P03372 P04040 P04179 P0DMV8 P0DMV9 P10809 P31689 P31749 P36776 P38646 P61604 Q00613 Q01523 Q16656 Q9NTG7 Q9Y2D1	AKT1 ATF5 ATFX CAT DEF5 DEFA5 DNAJ2 DNAJA1 ESR ESR1 FKHRL1 FOXO3 FOXO3A GRP75 HDJ2 HSF1 HSJ2 HSP60 HSP72 HSPA1 HSPA1A HSPA1B HSPA9 HSPA9B HSPD1 HSPE1 HSPF4 HSTF1 HSX70 HTRA2 LONP1 NR3A1 NRF1 OMI PKB PRSS15 PRSS25 RAC SIR2L3 SIRT3 SOD2 mt-HSP70	Homo sapiens (human)
Regulation of TP53 Activity through Phosphorylation	5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 ATR-interacting protein Aurora kinase A Aurora kinase B BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Casein kinase II subunit alpha' Casein kinase II subunit alpha Casein kinase II subunit beta Cell cycle checkpoint control protein RAD9A Cell cycle checkpoint control protein RAD9B Cell cycle checkpoint protein RAD17 Cell cycle checkpoint protein RAD1 Cellular tumor antigen p53 Checkpoint protein HUS1 Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 2 Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 2-binding protein 1 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Dual specificity tyrosine-phosphorylation-regulated kinase 2 E3 ubiquitin-protein ligase Mdm2 EKC/KEOPS complex subunit TP53RK Exonuclease 1 FACT complex subunit SPT16 FACT complex subunit SSRP1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Homeodomain-interacting protein kinase 1 Homeodomain-interacting protein kinase 2 MAP kinase-activated protein kinase 5 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 NUAK family SNF1-like kinase 1 Nibrin Nucleolar complex protein 2 homolog Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Serine/threonine-protein kinase ATR Serine/threonine-protein kinase Chk1 Serine/threonine-protein kinase Chk2 Serine/threonine-protein kinase PLK3 Serine/threonine-protein kinase STK11 TATA-binding protein-associated factor 2N TATA-box-binding protein Targeting protein for Xklp2 Transcription initiation factor TFIID subunit 1-like Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 11 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 3 Transcription initiation factor TFIID subunit 4 Transcription initiation factor TFIID subunit 4B Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 7-like Transcription initiation factor TFIID subunit 7 Transcription initiation factor TFIID subunit 9 Transcription initiation factor TFIID subunit 9B Tumor protein p53-inducible nuclear protein 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00268 O14757 O14965 O15151 O43741 O60285 O60671 O60921 O60934 O75943 O96017 P04637 P0CG47 P0CG48 P15927 P19784 P20226 P20248 P21675 P24941 P27694 P35244 P35249 P35250 P38398 P40937 P40938 P49848 P49959 P51530 P54132 P54619 P54646 P62979 P62987 P67870 P68400 P78396 Q00535 Q00987 Q08945 Q12962 Q13131 Q13315 Q13472 Q13526 Q13535 Q14191 Q15078 Q15542 Q15543 Q15544 Q15545 Q15759 Q15831 Q16514 Q16539 Q16594 Q5H9L4 Q5VWG9 Q6P1X5 Q6WBX8 Q86Z02 Q8IW41 Q8IZX4 Q8WXE1 Q92547 Q92630 Q92750 Q92804 Q92878 Q92993 Q96A56 Q96E14 Q96GD4 Q96S44 Q99638 Q99708 Q99728 Q9BSD3 Q9BX63 Q9H2X6 Q9H4B4 Q9H9A7 Q9HBM6 Q9UGI9 Q9UGJ0 Q9ULW0 Q9UQ84 Q9Y3T9 Q9Y478 Q9Y5B9	AGS1 AIK AIK2 AIM1 AIRK1 AIRK2 AMPK AMPK1 AMPK2 AMPKG3 ARK1 ARK2 ARK5 ATM ATR ATRIP AURA AURKA AURKB AYK1 BA2R BACH1 BARD1 BLM BRCA1 BRIP1 BTAK C12orf32 C16orf75 C20orf1 C20orf2 C20orf64 C9orf76 CCG1 CCGS CCN1 CCNA CCNA1 CCNA2 CDK2 CDK5 CDK5R CDK5R1 CDKN2 CDKN5 CDS1 CHEK1 CHEK2 CHK1 CHK2 CIF150 CK2A1 CK2A2 CK2N CNK CSBP CSBP1 CSBP2 CSNK2A1 CSNK2A2 CSNK2B CSPB1 CTIP DIL2 DNA2 DNA2L DYRK2 EXO1 EXOI FACT140 FACT80 FACTP140 FANCJ FNK FRP1 G5A GTF2D1 HCA519 HEX1 HIPK1 HIPK2 HNGS1 HTATIP HUS1 IAK1 KAT5 KIAA0083 KIAA0259 KIAA0537 KIAA0630 LKB1 MAPK11 MAPK14 MAPKAPK5 MDM2 MDM4 MDMX MRE11 MRE11A MXI2 MYAK NBAK2 NBN NBS NBS1 NCK5A NIR NOC2L NUAK1 OMPHK1 P53 P53DINP1 P95 PIN1 PJS PLK3 PRAK PRK PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRKM11 PRPK PSSALRE R24L RAD1 RAD17 RAD50 RAD53 RAD9A RAD9B RBBP8 RBP56 REC1 RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC2 RFC3 RFC4 RFC5 RHINO RHNO1 RMI1 RMI2 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A SAPK2 SAPK2A SAPK2B SIP SSRP1 STK1 STK11 STK12 STK15 STK5 STK6 SUPT16H TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1L TAF2 TAF2A TAF2B TAF2C TAF2C1 TAF2C2 TAF2D TAF2E TAF2F TAF2G TAF2H TAF2I TAF2J TAF2K TAF2N TAF2Q TAF3 TAF4 TAF4A TAF4B TAF5 TAF6 TAF7 TAF7L TAF9 TAF9B TAF9L TAFII105 TAFII130 TAFII135 TAFII18 TAFII20 TAFII30 TAFII31 TAFII55 TAFII70 TBP TF2D TFIID TIP60 TOP3 TOP3A TOPBP1 TP53 TP53INP1 TP53RK TPX2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WRN	Homo sapiens (human)
Insulin effects increased synthesis of Xylulose-5-Phosphate	Transaldolase Transketolase	P29401 P37837	TAL TALDO TALDO1 TALDOR TKT	Homo sapiens (human)
Activation of the AP-1 family of transcription factors	Cyclic AMP-dependent transcription factor ATF-2 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Protein c-Fos Transcription factor Jun	P01100 P05412 P15336 P27361 P28482 P45983 P45984 P53779 Q15759 Q16539	ATF2 CREB2 CREBP1 CSBP CSBP1 CSBP2 CSPB1 ERK1 ERK2 FOS G0S7 JNK1 JNK2 JNK3 JNK3A JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MXI2 PRKM1 PRKM10 PRKM11 PRKM2 PRKM3 PRKM8 PRKM9 SAPK1 SAPK1A SAPK1B SAPK1C SAPK2 SAPK2A SAPK2B	Homo sapiens (human)
Erythrocytes take up oxygen and release carbon dioxide	Ammonium transporter Rh type A Aquaporin-1 Band 3 anion transport protein Carbonic anhydrase 1 Carbonic anhydrase 2 Carbonic anhydrase 4 Hemoglobin subunit alpha Hemoglobin subunit beta	P00915 P00918 P02730 P22748 P29972 P68871 P69905 Q02094	AE1 AQP1 CA1 CA2 CA4 CHIP28 DI EPB3 HBA1 HBA2 HBB RH50 RHAG SLC4A1	Homo sapiens (human)
Melanin biosynthesis	5,6-dihydroxyindole-2-carboxylic acid oxidase L-dopachrome tautomerase Membrane-associated transporter protein P protein Tyrosinase	P14679 P17643 P40126 Q04671 Q9UMX9	AIM1 CAS2 D15S12 DCT MATP OCA2 P SLC45A2 TYR TYRP TYRP1 TYRP2 TYRRP	Homo sapiens (human)
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	Band 3 anion transport protein	P02730	AE1 DI EPB3 SLC4A1	Homo sapiens (human)
Mineralocorticoid biosynthesis	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 Cytochrome P450 11B2, mitochondrial Glycoprotein hormones alpha chain Lutropin subunit beta Steroid 21-hydroxylase	P01215 P01229 P08686 P14060 P19099 P26439	3BH CGA CYP11B2 CYP21 CYP21A2 CYP21B HSD3B1 HSD3B2 HSDB3A HSDB3B LHB	Homo sapiens (human)
Defective F9 variant does not activate FX	Coagulation factor IX Coagulation factor VIII Coagulation factor X	P00451 P00740 P00742	F10 F8 F8C F9	Homo sapiens (human)
Formation of the beta-catenin:TCF transactivating complex	B-cell CLL/lymphoma 9 protein B-cell CLL/lymphoma 9-like protein CREB-binding protein Catenin beta-1 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.1t Histone H3.2 Histone H3.3 Histone H4 Histone acetyltransferase KAT5 Histone acetyltransferase p300 Histone deacetylase 1 Histone-lysine N-methyltransferase 2D Lymphoid enhancer-binding factor 1 Menin Parafibromin Pygopus homolog 1 Pygopus homolog 2 RNA polymerase-associated protein LEO1 Retinoblastoma-binding protein 5 RuvB-like 1 Set1/Ash2 histone methyltransferase complex subunit ASH2 Telomerase reverse transcriptase Transcription activator BRG1 Transcription factor 7-like 1 Transcription factor 7-like 2 Transcription factor 7 Transducin-like enhancer protein 1 Transducin-like enhancer protein 2 Transducin-like enhancer protein 3 Transducin-like enhancer protein 4 Transformation/transcription domain-associated protein	O00255 O00512 O14686 O14746 O60814 P04908 P06899 P0C5Y9 P16104 P20671 P23527 P33778 P35222 P36402 P51532 P57053 P58876 P62805 P62807 P68431 P84243 Q04724 Q04725 Q04726 Q04727 Q09472 Q13547 Q15291 Q16695 Q16777 Q16778 Q6FI13 Q6P1J9 Q71DI3 Q71UI9 Q86UU0 Q8N257 Q8WVC0 Q92793 Q92993 Q93077 Q93079 Q96A08 Q99877 Q99878 Q99879 Q99880 Q9BRQ0 Q9BTM1 Q9HCS4 Q9NQB0 Q9UBL3 Q9UJU2 Q9Y265 Q9Y3Y4 Q9Y4A5	ALR ASH2L ASH2L1 BAF190A BCL9 BCL9L BRG1 C1orf28 CBP CDC73 CREBBP CTNNB CTNNB1 DLNB11 EP300 EST2 GRG4 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3-4 H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H3FT H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HDAC1 HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 HRPT2 HTATIP INO80H KAT5 KIAA1261 KIAA1547 KMT2D LEF1 LEO1 MEN1 MLL2 MLL4 NMP238 P300 PAF400 PYGO1 PYGO2 RBBP5 RBQ3 RDL RPD3L1 RUVBL1 SCG2 SMARCA4 SNF2B SNF2L4 TCF1 TCF3 TCF4 TCF7 TCF7L1 TCF7L2 TCS1 TERT TIP49 TIP49A TIP60 TLE1 TLE2 TLE3 TLE4 TRRAP TRT TSH2B	Homo sapiens (human)
Synthesis of PIPs at the plasma membrane	ADP-ribosylation factor 1 Cytoplasmic tyrosine-protein kinase BMX Inositol polyphosphate 4-phosphatase type II Inositol polyphosphate 5-phosphatase K Inositol polyphosphate 5-phosphatase OCRL Inositol polyphosphate-4-phosphatase type I A Myotubularin-related protein 13 Myotubularin-related protein 9 Myotubularin Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A Phosphatidylinositol 4-kinase type 2-alpha Phosphatidylinositol 4-kinase type 2-beta Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Phosphatidylinositol 4-phosphate 5-kinase type-1 beta Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8 Phosphatidylinositol-3-phosphate phosphatase MTMR1 Phosphoinositide 3-kinase regulatory subunit 5 Phosphoinositide 3-kinase regulatory subunit 6 Pleckstrin homology domain-containing family A member 1 Pleckstrin homology domain-containing family A member 2 Pleckstrin homology domain-containing family A member 3 Pleckstrin homology domain-containing family A member 4 Pleckstrin homology domain-containing family A member 5 Pleckstrin homology domain-containing family A member 6 Pleckstrin homology domain-containing family A member 8 RUN and FYVE domain-containing protein 1 Ras-related protein Rab-14 Ras-related protein Rab-4A Ras-related protein Rab-5A Synaptojanin-1 Synaptojanin-2 Tyrosine-protein phosphatase non-receptor type 13	O00329 O00443 O00459 O00750 O14986 O15056 O15327 O15357 O43426 O60331 O75747 P20338 P20339 P27986 P42336 P42338 P48426 P48736 P51813 P60484 P61106 P78356 P84077 Q01968 Q12923 Q13496 Q13613 Q13614 Q13615 Q15735 Q5UE93 Q86WG5 Q8NCE2 Q8TBX8 Q8TCG2 Q8WYR1 Q92569 Q92835 Q96EF0 Q96JA3 Q96PE3 Q96QG7 Q96T51 Q99755 Q9BT40 Q9BTU6 Q9H4M7 Q9HAU0 Q9HB19 Q9HB20 Q9HB21 Q9Y217 Q9Y2H5	ARF1 BMX C17orf38 C3orf29 C8orf9 CG2 CMT4B2 FAPP1 FAPP2 GRB1 INPP4A INPP4B INPP5D INPP5J INPP5K INPPL1 KIAA0348 KIAA0371 KIAA0589 KIAA0910 KIAA0969 KIAA1073 KIAA1686 KIAA1766 MMAC1 MTM1 MTMR1 MTMR13 MTMR14 MTMR2 MTMR3 MTMR6 MTMR8 MTMR9 OCRL OCRL1 PEPP1 PEPP2 PEPP3 PI4K2A PI4K2B PI5P4KA PIB5PA PIK3C1 PIK3C2A PIK3C2B PIK3C2G PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PIP5K2 PIP5K2A PIP5K2B PIP5K2C PIPP PLEKHA1 PLEKHA2 PLEKHA3 PLEKHA4 PLEKHA5 PLEKHA6 PLEKHA8 PNP1 PPS PTEN PTP1E PTPL1 PTPN13 RAB14 RAB4 RAB4A RAB5 RAB5A RABIP4 RUFY1 SBF2 SHIP SHIP1 SHIP2 SKIP STM7 SYNJ1 SYNJ2 TAPP1 TAPP2 TEP1 ZFYVE10 ZFYVE12	Homo sapiens (human)
Signalling to ERK5	Dual specificity mitogen-activated protein kinase kinase 5 Mitogen-activated protein kinase 7	Q13163 Q13164	BMK1 ERK5 MAP2K5 MAPK7 MEK5 MKK5 PRKM7 PRKMK5	Homo sapiens (human)
NGF-independant TRKA activation	Adenosine receptor A2a BDNF/NT-3 growth factors receptor High affinity nerve growth factor receptor Pituitary adenylate cyclase-activating polypeptide type I receptor Pituitary adenylate cyclase-activating polypeptide	P04629 P18509 P29274 P41586 Q16620	ADCYAP1 ADCYAP1R1 ADORA2 ADORA2A MTC NTRK1 NTRK2 TRK TRKA TRKB	Homo sapiens (human)
Interleukin-7 signaling	Bromodomain and WD repeat-containing protein 1 Cytokine receptor common subunit gamma Cytokine receptor-like factor 2 Cytokine-inducible SH2-containing protein Hepatocyte growth factor Histone H3.1 Histone H3.2 Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin-7 receptor subunit alpha Interleukin-7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 2 Thymic stromal lymphopoietin Transcription activator BRG1 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK3 V(D)J recombination-activating protein 1 V(D)J recombination-activating protein 2	O00459 O14508 O15524 P13232 P14210 P15918 P16871 P23458 P27986 P31785 P35568 P40763 P42229 P51532 P51692 P52333 P55895 P68431 Q71DI3 Q92569 Q969D9 Q9HC73 Q9NSE2 Q9NSI6 Q9Y4H2	APRF BAF190A BRG1 BRWD1 C21orf107 CIS2 CISH CRL2 CRLF2 G18 GRB1 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM HGF HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST2H3A HIST2H3C HIST2H3D HPTA IL2RG IL7 IL7R ILXR IRS1 IRS2 JAK1 JAK1A JAK1B JAK3 PIK3R1 PIK3R2 PIK3R3 RAG1 RAG2 RNF74 SMARCA4 SNF2B SNF2L4 SOCS1 SOCS2 SSI1 SSI2 STAT3 STAT5 STAT5A STAT5B STATI2 TIP3 TSLP TSLPR WDR9	Homo sapiens (human)
Signaling by GSK3beta mutants	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Catenin beta-1 Glycogen synthase kinase-3 beta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O15169 P25054 P30153 P30154 P35222 P48729 P49841 P62714 P67775 Q13362 Q14738 Q15172 Q15173 Q16537 Q5JTC6	AMER1 APC AXIN AXIN1 CSNK1A1 CTNNB CTNNB1 DP2.5 FAM123B GSK3B KIAA0044 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WTX	Homo sapiens (human)
Repression of WNT target genes	C-terminal-binding protein 1 C-terminal-binding protein 2 Histone deacetylase 1 Lymphoid enhancer-binding factor 1 TLE family member 5 Transcription factor 7-like 1 Transcription factor 7-like 2 Transcription factor 7 Transducin-like enhancer protein 1 Transducin-like enhancer protein 2 Transducin-like enhancer protein 3 Transducin-like enhancer protein 4	P36402 P56545 Q04724 Q04725 Q04726 Q04727 Q08117 Q13363 Q13547 Q9HCS4 Q9NQB0 Q9UJU2	AES CTBP CTBP1 CTBP2 GRG GRG4 GRG5 HDAC1 KIAA1261 KIAA1547 LEF1 RPD3L1 TCF1 TCF3 TCF4 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 TLE5	Homo sapiens (human)
ALK mutants bind TKIs	ALK tyrosine kinase receptor B-cell lymphoma/leukemia 11A Baculoviral IAP repeat-containing protein 6 Clathrin heavy chain 1 Echinoderm microtubule-associated protein-like 4 Eukaryotic translation initiation factor 2-alpha kinase 3 Fibronectin Huntingtin-interacting protein 1 Nucleophosmin Protein phosphatase 1B Striatin cAMP-dependent protein kinase type I-alpha regulatory subunit	O00291 O43815 O75688 P02751 P06748 P10644 Q00610 Q9H165 Q9HC35 Q9NR09 Q9NZJ5 Q9UM73	ALK BCL11A BIRC6 C2orf2 CLH17 CLTC CLTCL2 CTIP1 EIF2AK3 EMAPL4 EML4 EVI9 FN FN1 HIP1 KIAA0034 KIAA1289 KIAA1809 NPM NPM1 PEK PERK PKR1 PP2CB PPM1B PRKAR1 PRKAR1A STRN TSE1 ZNF856	Homo sapiens (human)
M-decay: degradation of maternal mRNAs by maternally stored factors	182 kDa tankyrase-1-binding protein CCR4-NOT transcription complex subunit 10 CCR4-NOT transcription complex subunit 11 CCR4-NOT transcription complex subunit 1 CCR4-NOT transcription complex subunit 2 CCR4-NOT transcription complex subunit 3 CCR4-NOT transcription complex subunit 4 CCR4-NOT transcription complex subunit 6-like CCR4-NOT transcription complex subunit 6 CCR4-NOT transcription complex subunit 7 CCR4-NOT transcription complex subunit 8 CCR4-NOT transcription complex subunit 9 Embryonic polyadenylate-binding protein 2 Endoribonuclease Dicer Eukaryotic initiation factor 4A-I Eukaryotic initiation factor 4A-II Eukaryotic initiation factor 4A-III Eukaryotic translation initiation factor 4 gamma 1 Eukaryotic translation initiation factor 4B Eukaryotic translation initiation factor 4E Polyadenylate-binding protein 1 Polyadenylate-binding protein-interacting protein 1 Protein BTG4 Protein argonaute-2 mRNA decay activator protein ZFP36L2	A5YKK6 A6NDY0 O75175 O95628 P06730 P11940 P23588 P38919 P47974 P60842 Q04637 Q14240 Q92600 Q96LI5 Q9C0C2 Q9H074 Q9H9A5 Q9NY30 Q9NZN8 Q9UFF9 Q9UIV1 Q9UKV8 Q9UKZ1 Q9ULM6 Q9UPY3	AGO2 BTG4 C2orf29 CAF1 CALIF CCR4 CCR4B CCR4a CDC36 CDC39 CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 CNOT9 DDX2A DDX2B DDX48 DICER DICER1 EIF2C2 EIF4A EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4EL1 EIF4F EIF4G EIF4G1 EIF4GI EPABP2 ERF2 HERNA KIAA0111 KIAA0691 KIAA0928 KIAA1007 KIAA1194 KIAA1741 LENG2 NOT1 NOT2 NOT3 NOT4 PAB1 PABP PABP1 PABPC1 PABPC2 PABPN1L PABPNL1 PAIP1 PC3B POP2 RCD1 RNF162C RQCD1 TAB182 TIS11D TNKS1BP1 ZFP36L2	Homo sapiens (human)
Defective F9 secretion	Coagulation factor IX	P00740	F9	Homo sapiens (human)

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