pexidartinib-resistant FLT3 mutants
|
|
|
|
|
Synthesis of Leukotrienes (LT) and Eoxins (EX)
|
|
|
- ABCC1
- ALOX15
- ALOX5
- ALOX5AP
- CYP4A11
- CYP4A2
- CYP4A22
- CYP4B1
- CYP4F11
- CYP4F2
- CYP4F22
- CYP4F3
- CYP4F8
- DPEP1
- DPEP2
- DPEP3
- FLAP
- GGT
- GGT1
- GGT5
- GGTLA1
- LOG15
- LOG5
- LTA4
- LTA4H
- LTB4DH
- LTB4H
- LTC4S
- MAPKAPK2
- MDP
- MRP
- MRP1
- PTGR1
- RDP
|
|
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
|
|
|
- APAF1
- API3
- BIRC4
- CASP3
- CASP7
- CASP9
- CPP32
- CYC
- CYCS
- DIABLO
- IAP3
- KIAA0413
- MCH3
- MCH6
- SMAC
- XIAP
|
|
Synthesis of 5-eicosatetraenoic acids
|
|
|
- ALOX5
- ALOX5AP
- FLAP
- GPX1
- GPX2
- GPX4
- LOG5
- LTC4S
- PON
- PON1
- PON2
- PON3
|
|
DAG and IP3 signaling
|
|
|
- AHCYL1
- DCAL
- INSP3R1
- IRBIT
- ITPR1
- ITPR2
- ITPR3
- PKCD
- PKCE
- PLC1
- PLCG1
- PRKCD
- PRKCE
- XPVKONA
|
|
Negative regulation of NOTCH4 signaling
|
|
|
- AKT1
- C7orf76
- CUL1
- DSS1
- EMC19
- ERIC1
- HC2
- HC3
- HC8
- HC9
- HSPC
- IFI5111
- INT3
- KIAA0072
- KIAA0107
- LMP10
- LMP2
- LMP7
- LMPX
- LMPY
- MB1
- MCB1
- MECL1
- MIP224
- MOV34L
- MSS1
- NOTCH4
- NU
- OCP2
- PFAAP4
- PKB
- POH1
- PROS26
- PROS27
- PROS30
- PSC2
- PSC3
- PSC5
- PSC8
- PSC9
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB10
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB5i
- PSMB6
- PSMB6i
- PSMB7
- PSMB8
- PSMB9
- PSMC1
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD10
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD4
- PSMD5
- PSMD6
- PSMD7
- PSMD8
- PSMD9
- PSME1
- PSME2
- PSME3
- PSMF1
- RAC
- RBX1
- RING10
- RING12
- RNF75
- ROC1
- RPS27A
- SEM1
- SHFDG1
- SHFM1
- SKP1
- SKP1A
- SUG1
- SUG2
- TACC3
- TBP1
- TBP7
- TCEB1L
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- X
- Y
- Y2
- YWHAZ
- Z
|
|
Respiratory syncytial virus genome replication
|
|
|
- HSP90A
- HSP90AA1
- HSP90AB1
- HSP90B
- HSPC1
- HSPC2
- HSPC3
- HSPCA
- HSPCB
- L
- M2-1
- M2-2
- N
- P
|
|
Activation of PKB
|
|
|
- AKT2
- C20orf97
- CTMP
- NIPK
- PDK1
- PDPK1
- SKIP3
- THEM4
- TRB3
- TRIB3
|
|
Chemokine receptors bind chemokines
|
|
|
- ACKR2
- ACKR3
- ACKR4
- BCA1
- BLC
- BLR1
- BONZO
- CCBP2
- CCL1
- CCL11
- CCL13
- CCL16
- CCL17
- CCL19
- CCL2
- CCL20
- CCL21
- CCL22
- CCL25
- CCL27
- CCL28
- CCL3
- CCL3L1
- CCL3L3
- CCL4
- CCL5
- CCL7
- CCR1
- CCR10
- CCR11
- CCR2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCRL1
- CCRL2
- CCXCR1
- CKRL1
- CKRL3
- CKRX
- CMK
- CMKAR1
- CMKBR1
- CMKBR2
- CMKBR3
- CMKBR4
- CMKBR5
- CMKBR6
- CMKBR7
- CMKBR8
- CMKBR9
- CMKBRL1
- CMKBRL2
- CMKOR1
- CMKR1
- CRAM
- CTAP3
- CX3CL1
- CX3CR1
- CXCL1
- CXCL10
- CXCL11
- CXCL12
- CXCL13
- CXCL16
- CXCL2
- CXCL3
- CXCL4
- CXCL5
- CXCL6
- CXCL7
- CXCL8
- CXCL9
- CXCR1
- CXCR2
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
- D17S136E
- D17S1718
- D6
- EBI1
- ELC
- ENA78
- EVI1
- FKN
- G0S19-1
- G0S19-2
- GCP2
- GPR13
- GPR159
- GPR2
- GPR28
- GPR29
- GPR5
- GPR9
- GRO
- GRO1
- GRO2
- GRO3
- GROA
- GROB
- GROG
- HCR
- IL8
- IL8RA
- IL8RB
- ILC
- ILINCK
- INP10
- ITAC
- LAG1
- LARC
- LTN
- MCP1
- MCP3
- MCP4
- MDC
- MDR15
- MGSA
- MIG
- MIP1A
- MIP1B
- MIP2A
- MIP3A
- MIP3B
- NCC1
- NCC4
- NTT
- PF4
- PPBP
- RDC1
- SCYA1
- SCYA11
- SCYA13
- SCYA16
- SCYA17
- SCYA19
- SCYA2
- SCYA20
- SCYA21
- SCYA22
- SCYA25
- SCYA27
- SCYA28
- SCYA3
- SCYA3L1
- SCYA4
- SCYA5
- SCYA6
- SCYA7
- SCYAR1
- SCYB1
- SCYB10
- SCYB11
- SCYB13
- SCYB16
- SCYB2
- SCYB3
- SCYB4
- SCYB5
- SCYB6
- SCYB7
- SCYB9
- SCYB9B
- SCYC1
- SCYC2
- SCYD1
- SDF1
- SDF1A
- SDF1B
- SRPSOX
- STRL22
- STRL33
- TARC
- TECK
- TGB1
- THBGB1
- TYMSTR
- VSHK1
- XCL1
- XCL2
- XCR1
|
|
Interleukin-38 signaling
|
|
|
- FIL1T
- IL1F10
- IL1HY2
- IL1RAPL1
- IL1RL2
- IL1RRP2
- IL38
- JNK1
- MAPK8
- OPHN4
- PRKM8
- SAPK1
- SAPK1C
|
|
MET activates PTK2 signaling
|
|
|
- CD49B
- FAK
- FAK1
- FNRB
- HGF
- HPTA
- ITGA2
- ITGA3
- ITGB1
- KIAA0533
- KIAA1907
- LAMA
- LAMA1
- LAMA2
- LAMA3
- LAMA4
- LAMA5
- LAMB1
- LAMB2
- LAMB2T
- LAMB3
- LAMC1
- LAMC2
- LAMC3
- LAMM
- LAMNA
- LAMNB1
- LAMNB2
- LAMS
- MDF2
- MET
- MSK12
- MSK18
- PTK2
- SRC
- SRC1
|
|
Potassium transport channels
|
|
|
- KCNJ1
- KCNJ10
- KCNJ16
- ROMK1
|
|
Fc epsilon receptor (FCERI) signaling
|
|
|
- APY
- FCE1A
- FCER1A
- FCER1B
- FCER1G
- IGER
- IGHE
- IGHV
- IGHV1-2
- IGHV1-46
- IGHV1-69
- IGHV2-5
- IGHV2-70
- IGHV3-11
- IGHV3-13
- IGHV3-23
- IGHV3-30
- IGHV3-33
- IGHV3-48
- IGHV3-53
- IGHV3-7
- IGHV3-9
- IGHV4-34
- IGHV4-39
- IGHV4-59
- IGHV7-81
- IGKC
- IGKV1-12
- IGKV1-16
- IGKV1-17
- IGKV1-33
- IGKV1-39
- IGKV1-5
- IGKV1D-12
- IGKV1D-16
- IGKV1D-33
- IGKV1D-39
- IGKV2-28
- IGKV2-29
- IGKV2-30
- IGKV2D-28
- IGKV2D-30
- IGKV2D-40
- IGKV3-11
- IGKV3-15
- IGKV3-20
- IGKV3D-20
- IGKV4-1
- IGKV5-2
- IGLC1
- IGLC2
- IGLC3
- IGLC6
- IGLC7
- IGLV
- IGLV1-40
- IGLV1-44
- IGLV1-47
- IGLV1-51
- IGLV2-11
- IGLV2-14
- IGLV2-23
- IGLV2-8
- IGLV3-1
- IGLV3-19
- IGLV3-21
- IGLV3-25
- IGLV3-27
- IGLV6-57
- IGLV7-43
- JTK8
- LYN
- MS4A2
- SYK
- V1-11
- V1-13
- V1-16
- V1-20
- V1-3
- V1-5
- V1-7
- V1-9
- V2-11
- V2-15
- V2-17
- V2-19
- V2-8
- V3-2
- V3-3
- V3-4
- V4-1
- V4-2
- V4-6
- V5-1
- V5-4
- V5-6
|
|
NFE2L2 regulating tumorigenic genes
|
|
|
- AREG
- AREGB
- BCL2
- BCL2L
- BCL2L1
- BCLX
- CBP
- CREBBP
- EGF
- EP300
- MAFK
- NFE2L2
- NOTCH1
- NRF2
- P300
- PDGF1
- PDGFA
- SDGF
- SP1
- TAN1
- TSFP1
|
|
Defective GCLC causes HAGGSD
|
|
|
- GCLC
- GCLM
- GLCL
- GLCLC
- GLCLR
|
|
RHO GTPases activate KTN1
|
|
|
- ARH12
- ARHA
- ARHG
- CDC42
- CG1
- KIAA0004
- KIF5A
- KIF5B
- KLC
- KLC1
- KLC2
- KLC2L
- KLC3
- KLC4
- KNS
- KNS1
- KNS2
- KNSL8
- KTN1
- NKHC1
- RAC1
- RHO12
- RHOA
- RHOG
- TC25
|
|
RUNX2 regulates bone development
|
|
|
- BSP1
- CBFB
- DPC4
- MADH1
- MADH4
- MADH6
- MADR1
- RBM14
- SIP
- SMAD1
- SMAD4
- SMAD6
|
|
Formation of annular gap junctions
|
|
|
- AP2M1
- CLAPM1
- CLH17
- CLH22
- CLTA
- CLTB
- CLTC
- CLTCL
- CLTCL1
- CLTCL2
- CLTD
- DAB2
- DNM
- DNM1
- DNM2
- DOC2
- DYN2
- GJA1
- GJAL
- KIAA0034
- KIAA0109
|
|
Glycerophospholipid biosynthesis
|
|
|
- AGK
- CPN1
- CPN3
- CPNE1
- CPNE3
- CPNE6
- CPNE7
- KIAA0636
- MULK
|
|
Nuclear Envelope Breakdown
|
|
|
- BAF
- BANF1
- BCRG1
- EDMD
- EMD
- LEMD2
- LEMD3
- MAN1
- STA
- VRK1
|
|
KIT mutants bind TKIs
|
|
|
|
|
Interleukin-3, Interleukin-5 and GM-CSF signaling
|
|
|
- CSF2
- CSF2R
- CSF2RA
- CSF2RB
- CSF2RY
- GMCSF
- GRB1
- HCP
- IL3
- IL3R
- IL3RA
- IL3RB
- IL5
- IL5R
- IL5RA
- IL5RB
- JAK2
- PIK3C1
- PIK3CA
- PIK3CB
- PIK3CD
- PIK3R1
- PIK3R2
- PIK3R3
- PKACA
- PRKACA
- PSCTK4
- PTP1C
- PTP2C
- PTPN11
- PTPN6
- SHC
- SHC1
- SHCA
- SHPTP2
- STAT5
- STAT5A
- STAT5B
- TEC
- VAV
- VAV1
- YWHAZ
|
|
EML4 and NUDC in mitotic spindle formation
|
|
|
- AHCTF1
- AIK2
- AIM1
- AIRK2
- API4
- APITD1
- ARK2
- AURKB
- B9D2
- BIRC5
- BUB1
- BUB1B
- BUB1L
- BUB3
- BUBR1
- C16orf56
- C16orf60
- C18orf24
- C1orf155
- C1orf48
- C20orf172
- C22orf18
- C2orf2
- C6orf139
- CASC5
- CCDC99
- CDC20
- CDCA1
- CDCA8
- CENPA
- CENPC
- CENPC1
- CENPE
- CENPF
- CENPH
- CENPI
- CENPK
- CENPL
- CENPM
- CENPN
- CENPO
- CENPP
- CENPQ
- CENPR
- CENPS
- CENPT
- CENPU
- CKAP5
- CLASP1
- CLASP2
- CLIP1
- CRM1
- CYLN1
- D3S1231E
- DHC1
- DLC1
- DLC2
- DNCH1
- DNCI1
- DNCI2
- DNCIC1
- DNCIC2
- DNCL
- DNCL1
- DNCLC1
- DNCLI1
- DNCLI2
- DNECL
- DSN1
- DYHC
- DYNC1H1
- DYNC1I1
- DYNC1I2
- DYNC1LI1
- DYNC1LI2
- DYNLL1
- DYNLL2
- ELYS
- EMAPL4
- EML4
- EOPA
- ERCC6L
- FAAP16
- FAM33A
- FSHPRH1
- HDLC1
- HEC
- HEC1
- IAP4
- ICEN19
- ICEN22
- ICEN24
- ICEN32
- ICEN33
- ICEN35
- ICEN36
- ICEN37
- ICEN39
- ICEN7
- INCENP
- ITGB3BP
- KIAA0044
- KIAA0097
- KIAA0166
- KIAA0197
- KIAA0325
- KIAA0622
- KIAA0627
- KIAA1361
- KIAA1470
- KIAA1570
- KIAA1835
- KIAA1995
- KIF18A
- KIF2
- KIF2A
- KIF2B
- KIF2C
- KLIP1
- KNL1
- KNS2
- KNSL6
- KNTC1
- KNTC2
- LIC2
- LIS1
- LRPR1
- MAD1
- MAD1L1
- MAD2
- MAD2L1
- MAD3L
- MAP3K16
- MAPRE1
- MARKK
- MAST1
- MCM21R
- MDCR
- MDS
- MHF1
- MIS12
- MIS13
- MITAP1
- MKSR2
- MLF1IP
- MPS1
- NDC80
- NDE1
- NDEL1
- NEK6
- NEK7
- NEK8
- NEK9
- NERCC
- NRIF3
- NSL1
- NUDC
- NUDE
- NUDEL
- NUF2
- NUF2R
- NUP107
- NUP120
- NUP133
- NUP160
- NUP358
- NUP37
- NUP43
- NUP75
- NUP85
- PAFAH1B1
- PAFAHA
- PANE1
- PBIP1
- PCNT1
- PESCRG3
- PICH
- PLK
- PLK1
- PMF1
- PPP1CC
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5A
- PPP2R5B
- PPP2R5C
- PPP2R5D
- PPP2R5E
- RANBP2
- RANGAP1
- RCC2
- RPS27
- RSN
- SD
- SEC13
- SEC13A
- SEC13L1
- SEC13R
- SGO1
- SGO2
- SGOL1
- SGOL2
- SKA1
- SKA2
- SPBC24
- SPBC25
- SPC24
- SPC25
- SPDL1
- SSK1
- STK1
- STK12
- STK5
- TAOK1
- TD60
- TMBS62
- TXBP181
- XPO1
- ZW10
- ZWILCH
- ZWINT
|
|
FCERI mediated Ca+2 mobilization
|
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- Calcineurin subunit B type 1
- Calmodulin-1
- GRB2-related adapter protein 2
- Guanine nucleotide exchange factor VAV2
- Guanine nucleotide exchange factor VAV3
- IGHV7-81 protein
- Immunoglobulin heavy constant epsilon
- Immunoglobulin heavy variable 1-2
- Immunoglobulin heavy variable 1-46
- Immunoglobulin heavy variable 1-69
- Immunoglobulin heavy variable 2-5
- Immunoglobulin heavy variable 2-70
- Immunoglobulin heavy variable 3-11
- Immunoglobulin heavy variable 3-13
- Immunoglobulin heavy variable 3-23
- Immunoglobulin heavy variable 3-30
- Immunoglobulin heavy variable 3-33
- Immunoglobulin heavy variable 3-48
- Immunoglobulin heavy variable 3-53
- Immunoglobulin heavy variable 3-7
- Immunoglobulin heavy variable 3-9
- Immunoglobulin heavy variable 4-34
- Immunoglobulin heavy variable 4-39
- Immunoglobulin heavy variable 4-59
- Immunoglobulin kappa constant
- Immunoglobulin kappa variable 1-12
- Immunoglobulin kappa variable 1-16
- Immunoglobulin kappa variable 1-17
- Immunoglobulin kappa variable 1-33
- Immunoglobulin kappa variable 1-39
- Immunoglobulin kappa variable 1-5
- Immunoglobulin kappa variable 1D-12
- Immunoglobulin kappa variable 1D-16
- Immunoglobulin kappa variable 1D-33
- Immunoglobulin kappa variable 1D-39
- Immunoglobulin kappa variable 2-28
- Immunoglobulin kappa variable 2-29
- Immunoglobulin kappa variable 2-30
- Immunoglobulin kappa variable 2D-28
- Immunoglobulin kappa variable 2D-30
- Immunoglobulin kappa variable 2D-40
- Immunoglobulin kappa variable 3-11
- Immunoglobulin kappa variable 3-15
- Immunoglobulin kappa variable 3-20
- Immunoglobulin kappa variable 3D-20
- Immunoglobulin kappa variable 4-1
- Immunoglobulin kappa variable 5-2
- Immunoglobulin lambda constant 1
- Immunoglobulin lambda constant 2
- Immunoglobulin lambda constant 3
- Immunoglobulin lambda constant 6
- Immunoglobulin lambda constant 7
- Immunoglobulin lambda variable 1-40
- Immunoglobulin lambda variable 1-44
- Immunoglobulin lambda variable 1-47
- Immunoglobulin lambda variable 1-51
- Immunoglobulin lambda variable 2-11
- Immunoglobulin lambda variable 2-14
- Immunoglobulin lambda variable 2-23
- Immunoglobulin lambda variable 2-8
- Immunoglobulin lambda variable 3-19
- Immunoglobulin lambda variable 3-1
- Immunoglobulin lambda variable 3-21
- Immunoglobulin lambda variable 3-25
- Immunoglobulin lambda variable 3-27
- Immunoglobulin lambda variable 6-57
- Immunoglobulin lambda variable 7-43
- Immunolglobulin kappa light chain variable region L22 (Fragment)
- Inositol 1,4,5-trisphosphate receptor type 2
- Inositol 1,4,5-trisphosphate receptor type 3
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Lymphocyte cytosolic protein 2
- Nuclear factor of activated T-cells, cytoplasmic 1
- Nuclear factor of activated T-cells, cytoplasmic 2
- Nuclear factor of activated T-cells, cytoplasmic 3
- Protein phosphatase 3 catalytic subunit alpha
- Proto-oncogene vav
- S-adenosylhomocysteine hydrolase-like protein 1
- Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
- Son of sevenless homolog 1
- Tyrosine-protein kinase BTK
- Tyrosine-protein kinase ITK/TSK
- Tyrosine-protein kinase Lyn
- Tyrosine-protein kinase SYK
- Tyrosine-protein kinase TXK
- Tyrosine-protein kinase Tec
- UGa8H (Fragment)
- V1-11 protein (Fragment)
- V1-13 protein (Fragment)
- V1-16 protein (Fragment)
- V1-20 protein (Fragment)
- V1-3 protein (Fragment)
- V1-5 protein (Fragment)
- V1-7 protein (Fragment)
- V1-9 protein (Fragment)
- V2-11 protein (Fragment)
- V2-15 protein (Fragment)
- V2-17 protein (Fragment)
- V2-19 protein (Fragment)
- V2-8 protein (Fragment)
- V3-2 protein (Fragment)
- V3-3 protein (Fragment)
- V3-4 protein (Fragment)
- V4-1 protein (Fragment)
- V4-2 protein (Fragment)
- V4-6 protein (Fragment)
- V5-1 protein (Fragment)
- V5-4 protein (Fragment)
- V5-6 protein (Fragment)
|
|
- AGMX1
- AHCYL1
- ATK
- BPK
- BTK
- CALM
- CALM1
- CALNA
- CALNA2
- CALNB
- CAM
- CAM1
- CNA
- CNA2
- CNB
- DCAL
- EMT
- GADS
- GRAP2
- GRB2L
- GRID
- IGHE
- IGHV
- IGHV1-2
- IGHV1-46
- IGHV1-69
- IGHV2-5
- IGHV2-70
- IGHV3-11
- IGHV3-13
- IGHV3-23
- IGHV3-30
- IGHV3-33
- IGHV3-48
- IGHV3-53
- IGHV3-7
- IGHV3-9
- IGHV4-34
- IGHV4-39
- IGHV4-59
- IGHV7-81
- IGKC
- IGKV1-12
- IGKV1-16
- IGKV1-17
- IGKV1-33
- IGKV1-39
- IGKV1-5
- IGKV1D-12
- IGKV1D-16
- IGKV1D-33
- IGKV1D-39
- IGKV2-28
- IGKV2-29
- IGKV2-30
- IGKV2D-28
- IGKV2D-30
- IGKV2D-40
- IGKV3-11
- IGKV3-15
- IGKV3-20
- IGKV3D-20
- IGKV4-1
- IGKV5-2
- IGLC1
- IGLC2
- IGLC3
- IGLC6
- IGLC7
- IGLV
- IGLV1-40
- IGLV1-44
- IGLV1-47
- IGLV1-51
- IGLV2-11
- IGLV2-14
- IGLV2-23
- IGLV2-8
- IGLV3-1
- IGLV3-19
- IGLV3-21
- IGLV3-25
- IGLV3-27
- IGLV6-57
- IGLV7-43
- INSP3R1
- IRBIT
- ITK
- ITPR1
- ITPR2
- ITPR3
- JTK8
- LCP2
- LYK
- LYN
- NFAT1
- NFAT2
- NFAT4
- NFATC
- NFATC1
- NFATC2
- NFATC3
- NFATP
- PLC1
- PLCG1
- PLCG2
- PPP3CA
- PPP3CB
- PPP3R1
- PSCTK4
- PTK4
- RLK
- SOS1
- SYK
- TEC
- TXK
- V1-11
- V1-13
- V1-16
- V1-20
- V1-3
- V1-5
- V1-7
- V1-9
- V2-11
- V2-15
- V2-17
- V2-19
- V2-8
- V3-2
- V3-3
- V3-4
- V4-1
- V4-2
- V4-6
- V5-1
- V5-4
- V5-6
- VAV
- VAV1
- VAV2
- VAV3
- XPVKONA
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APC truncation mutants are not K63 polyubiquitinated
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