GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **1176 - 1200** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism ▲	GlyTouCan ID
G2/M DNA replication checkpoint	Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 G2/mitotic-specific cyclin-B2 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Wee1-like protein kinase	O95067 P06493 P14635 P30291 Q99640	CCNB CCNB1 CCNB2 CDC2 CDC28A CDK1 CDKN1 MYT1 P34CDC2 PKMYT1 WEE1	Homo sapiens (human)
CS/DS degradation	Alpha-L-iduronidase Arylsulfatase B Beta-hexosaminidase subunit alpha Beta-hexosaminidase subunit beta Biglycan Brevican core protein Chondroitin sulfate proteoglycan 4 Chondroitin sulfate proteoglycan 5 Decorin Hyaluronidase-1 Hyaluronidase-3 Iduronate 2-sulfatase Neurocan core protein Versican core protein	O14594 O43820 O95196 P06865 P07585 P07686 P13611 P15848 P21810 P22304 P35475 Q12794 Q6UVK1 Q96GW7	ARSB BCAN BEHAB BGN CALEB CSPG2 CSPG3 CSPG4 CSPG5 CSPG7 DCN HEXA HEXB HYAL1 HYAL3 IDS IDUA LUCA1 LUCA3 MCSP NCAN NEUR NGC SIDS SLRR1A SLRR1B VCAN	Homo sapiens (human)	G27025MB
RHOC GTPase cycle	A-kinase anchor protein 13 ATP-binding cassette sub-family D member 3 Active breakpoint cluster region-related protein Acyl-CoA-binding domain-containing protein 5 Anillin Breakpoint cluster region protein Caveolae-associated protein 1 Caveolin-1 Cell surface glycoprotein MUC18 Citron Rho-interacting kinase Coiled-coil domain-containing protein 187 Complement component 1 Q subcomponent-binding protein, mitochondrial DEP domain-containing protein 1B Delta(14)-sterol reductase LBR Disheveled-associated activator of morphogenesis 1 Erbin Flotillin-1 Flotillin-2 Formin-like protein 2 Formin-like protein 3 Guanine nucleotide exchange factor DBS Guanine nucleotide exchange factor VAV2 Junction plakoglobin Lamina-associated polypeptide 2, isoforms beta/gamma Macoilin Oligophrenin-1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Phosphatidylinositol 3-kinase regulatory subunit alpha Protein ERGIC-53 Protein diaphanous homolog 1 Protein diaphanous homolog 3 Proto-oncogene DBL Rac GTPase-activating protein 1 Ras GTPase-activating-like protein IQGAP1 Ras GTPase-activating-like protein IQGAP3 Rho GDP-dissociation inhibitor 1 Rho GTPase-activating protein 18 Rho GTPase-activating protein 1 Rho GTPase-activating protein 21 Rho GTPase-activating protein 26 Rho GTPase-activating protein 32 Rho GTPase-activating protein 35 Rho GTPase-activating protein 39 Rho GTPase-activating protein 5 Rho GTPase-activating protein 7 Rho guanine nucleotide exchange factor 10-like protein Rho guanine nucleotide exchange factor 10 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 12 Rho guanine nucleotide exchange factor 17 Rho guanine nucleotide exchange factor 1 Rho guanine nucleotide exchange factor 25 Rho guanine nucleotide exchange factor 28 Rho guanine nucleotide exchange factor 40 Rho guanine nucleotide exchange factor 5 Rho-associated protein kinase 1 Rho-associated protein kinase 2 Rho-related GTP-binding protein RhoC Rhotekin STE20-like serine/threonine-protein kinase Serine/threonine-protein kinase 10 Serine/threonine-protein kinase N1 Serine/threonine-protein kinase N2 Serine/threonine-protein kinase N3 StAR-related lipid transfer protein 13 Stomatin Syntaxin-5 Tight junction protein ZO-2 Transferrin receptor protein 1 Transforming protein RhoA Unconventional myosin-IXb Vang-like protein 1 Vesicle-associated membrane protein 3 Vesicle-associated membrane protein-associated protein B/C	A0A096LP49 A7KAX9 O14578 O15013 O15068 O15085 O60610 O60890 O75116 O75955 O94804 O95292 P02786 P08134 P10911 P11274 P14923 P27105 P27986 P28288 P42167 P43121 P46940 P49257 P52565 P52735 P61586 Q03135 Q07021 Q07960 Q12774 Q12802 Q12979 Q13017 Q13190 Q13459 Q13464 Q14254 Q14739 Q15836 Q16512 Q16513 Q5T5U3 Q5T8D3 Q6NZI2 Q6P5Z2 Q86VI3 Q86VW2 Q8IVF7 Q8N1W1 Q8N392 Q8N5G2 Q8TAA9 Q8TCU6 Q8TER5 Q8WUY9 Q92888 Q96PE2 Q96PY5 Q96QB1 Q96RT1 Q9BST9 Q9C0H5 Q9H0H5 Q9H2G2 Q9HCE6 Q9NQW6 Q9NRY4 Q9NSV4 Q9NZN5 Q9UDY2 Q9UNA1 Q9Y3M8 Q9Y4D1	ABCD3 ABR ACBD5 AKAP13 ANLN ARH12 ARH9 ARHA ARHC ARHGAP1 ARHGAP10 ARHGAP18 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP5 ARHGAP7 ARHGDIA ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF17 ARHGEF25 ARHGEF28 ARHGEF40 ARHGEF5 BCR BCR1 BND7 BRX C1QBP CAV CAV1 CAVIN1 CCDC187 CDC42GAP CIT CRIK CTNNG D22S11 DAAM1 DBL DEPDC1B DIAP1 DIAP3 DIAPH1 DIAPH3 DLC1 DLC2 DP3 EPB72 ERBB2IP ERBIN ERGIC53 ESA1 F5F8D FHOD2 FHOD3 FLOT1 FLOT2 FMNL2 FMNL3 FRL2 GC1QBP GDIA1 GEFT GRAF GRB1 GRF1 GRINCHGEF GRIT GRLF1 GT650 HABP1 HT31 IQGAP1 IQGAP3 JUP KIAA0051 KIAA0204 KIAA0294 KIAA0337 KIAA0362 KIAA0380 KIAA0382 KIAA0619 KIAA0621 KIAA0666 KIAA0712 KIAA0949 KIAA1225 KIAA1415 KIAA1424 KIAA1478 KIAA1626 KIAA1688 KIAA1722 KIAA1723 KIAA1902 KIAA1996 KIAA1998 KIAA2014 LAP2 LARG LBC LBR LMAN1 LOK M17S1 MACO1 MCAM MCF2 MCF2L MGCRACGAP MUC18 MYO9B MYR5 OPHN1 OPHN1L OST P190A PAK1 PIK3R1 PKN PKN1 PKN2 PKN3 PKNBETA PMP70 PREX1 PRK1 PRK2 PRKCL1 PRKCL2 PTRF PXMP1 RACGAP1 RGNEF RHO12 RHOA RHOC RHOGAP1 RHOGAP5 RICS ROCK1 ROCK2 RTKN RTKN1 SF2P32 SLK SOLO STARD12 STARD13 STB2 STK10 STK2 STK21 STOM STX5 STX5A SYB3 TEM4 TFRC TIM TJP2 TMEM57 TMPO VAMP3 VANGL1 VAPB VAV2 WBP3 X104 XTP8 ZO2 p190ARHOGAP	Homo sapiens (human)
Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)	Sodium/potassium/calcium exchanger 1	O60721	KIAA0702 NCKX1 SLC24A1	Homo sapiens (human)
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)	Vasopressin V1a receptor Vasopressin V1b receptor Vasopressin-neurophysin 2-copeptin	P01185 P37288 P47901	ARVP AVP AVPR1 AVPR1A AVPR1B AVPR3 VP VPR3	Homo sapiens (human)
SHC-mediated cascade:FGFR3	Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 9 GTPase HRas GTPase NRas Son of sevenless homolog 1	O43320 O76093 P01111 P01112 P05230 P08620 P09038 P31371 Q07889 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF2 FGF20 FGF23 FGF4 FGF9 FGFA FGFB HRAS HRAS1 HST HSTF1 HYPF KS3 NRAS SOS1	Homo sapiens (human)
MAPK3 (ERK1) activation	Cyclin-dependent kinase 1 Dual specificity mitogen-activated protein kinase kinase 1 Interleukin-6 receptor subunit alpha Interleukin-6 Mitogen-activated protein kinase 3 Non-receptor tyrosine-protein kinase TYK2 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein phosphatase non-receptor type 11	O60674 P05231 P06493 P08887 P23458 P27361 P29597 Q02750 Q06124	CDC2 CDC28A CDK1 CDKN1 ERK1 IFNB2 IL6 IL6R JAK1 JAK1A JAK1B JAK2 MAP2K1 MAPK3 MEK1 P34CDC2 PRKM3 PRKMK1 PTP2C PTPN11 SHPTP2 TYK2	Homo sapiens (human)
Cytoprotection by HMOX1	3'-5' exoribonuclease HELZ2 Albumin Biliverdin reductase A CREB-binding protein Chromodomain-helicase-DNA-binding protein 9 Cytochrome c oxidase subunit 1 Cytochrome c oxidase subunit 2 Cytochrome c oxidase subunit 3 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Cytochrome c oxidase subunit 4 isoform 2, mitochondrial Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase subunit 5B, mitochondrial Cytochrome c oxidase subunit 6A1, mitochondrial Cytochrome c oxidase subunit 6A2, mitochondrial Cytochrome c oxidase subunit 6B1 Cytochrome c oxidase subunit 6B2 Cytochrome c oxidase subunit 6C Cytochrome c oxidase subunit 7A-related protein, mitochondrial Cytochrome c oxidase subunit 7A1, mitochondrial Cytochrome c oxidase subunit 7A2, mitochondrial Cytochrome c oxidase subunit 7B, mitochondrial Cytochrome c oxidase subunit 7C, mitochondrial Cytochrome c oxidase subunit 8A, mitochondrial Cytochrome c oxidase subunit 8C, mitochondrial Cytochrome c oxidase subunit NDUFA4 Cytochrome c F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 Fatty acid-binding protein, liver Flavin reductase (NADPH) HIG1 domain family member 1C Heme oxygenase 1 Heme oxygenase 2 Hemoglobin subunit alpha Hemoglobin subunit beta Histone deacetylase 3 Histone-arginine methyltransferase CARM1 Mediator of RNA polymerase II transcription subunit 1 Multidrug resistance-associated protein 1 NACHT, LRR and PYD domains-containing protein 3 Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 6 Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Paired amphipathic helix protein Sin3a Peroxisome proliferator-activated receptor alpha Protein-tyrosine kinase 6 Retinoic acid receptor RXR-alpha SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Signal transducer and activator of transcription 3 Signal-transducing adaptor protein 2 Thioredoxin-interacting protein Trimethylguanosine synthase	A8MV81 O00483 O14548 O15379 O60907 O75376 P00395 P00403 P00414 P02768 P07148 P09601 P09669 P10176 P10606 P12074 P13073 P14406 P14854 P15954 P19793 P20674 P24310 P24311 P30043 P30519 P33527 P40763 P53004 P68871 P69905 P99999 Q02221 Q07869 Q13882 Q14686 Q15596 Q15648 Q15788 Q3L8U1 Q6STE5 Q6YFQ2 Q7Z4L0 Q86X55 Q92793 Q96KJ9 Q96P20 Q96RS0 Q96ST3 Q9BYK8 Q9BZK7 Q9H3M7 Q9UGK3 Q9Y618	ABCC1 AIB3 ALB APRF ARC205 BAF60C BHLHE74 BHLHE75 BKS BLVR BLVRA BLVRB BRK BVR C1orf7 CARM1 CBP CHD9 CIAS1 COI COII COIII COX2 COX4 COX4I1 COX4I2 COX4L2 COX5A COX5B COX6A COX6A1 COX6A2 COX6AH COX6AL COX6B COX6B1 COX6B2 COX6C COX7A1 COX7A2 COX7A2L COX7AH COX7AL COX7AR COX7B COX7C COX7RP COX8 COX8A COX8C COX8L COXI COXII COXIII CREBBP CRSP1 CRSP200 CTG26 CYC CYCS DRIP205 DRIP230 FABP1 FABPL FLR HBA1 HBA2 HBB HCA137 HDAC3 HELZ2 HIGD1C HMOX1 HMOX2 HO HO1 HO2 IRA1 KIAA0181 KIAA0308 KIAA1047 KIAA1769 KISH2 MED1 MRP MRP1 MT-CO1 MT-CO2 MT-CO3 MTCO1 MTCO2 MTCO3 NALP3 NCOA1 NCOA2 NCOA6 NCOA6IP NCOR1 NCOR2 NDUFA4 NLRP3 NR1C1 NR2B1 PBP PIMT PPAR PPARA PPARBP PPARGBP PRIC285 PRIC320 PRMT4 PTK6 PYPAF1 RAP250 RB18A RXRA SCAN SIN3A SMARCD3 SRC1 SRC2 STAP2 STAT3 TBL1 TBL1X TBL1XR1 TBLR1 TGS1 TIF2 TRAP220 TRBP TRIP2 TXNIP UBIE UBIE2 VDUP1	Homo sapiens (human)
Defective DPAGT1 causes CDG-1j, CMSTA2	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	Q9H3H5	DPAGT1 DPAGT2	Homo sapiens (human)
Regulation of cholesterol biosynthesis by SREBP (SREBF)	GTP-binding nuclear protein Ran Importin subunit beta-1 Insulin-induced gene 1 protein Insulin-induced gene 2 protein Membrane-bound transcription factor site-1 protease Membrane-bound transcription factor site-2 protease Protein transport protein Sec23A Protein transport protein Sec24A Protein transport protein Sec24B Protein transport protein Sec24C Protein transport protein Sec24D Small COPII coat GTPase SAR1B Sterol regulatory element-binding protein 2 Sterol regulatory element-binding protein cleavage-activating protein	O15503 O43462 O94855 O95486 O95487 P53992 P62826 Q12770 Q12772 Q14703 Q14974 Q15436 Q9Y5U4 Q9Y6B6	ARA24 BHLHD2 INSIG1 INSIG2 KIAA0079 KIAA0091 KIAA0199 KIAA0755 KPNB1 MBTPS1 MBTPS2 NTF97 RAN S1P S2P SAR1B SARA2 SARB SCAP SEC23A SEC24A SEC24B SEC24C SEC24D SKI1 SREBF2 SREBP2	Homo sapiens (human)
Negative regulation of the PI3K/AKT network	Acyl-coenzyme A thioesterase THEM4 PH domain leucine-rich repeat-containing protein phosphatase 1 PH domain leucine-rich repeat-containing protein phosphatase 2 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Tribbles homolog 3	O60346 P31749 P31751 P60484 Q5T1C6 Q6ZVD8 Q96RU7 Q9Y243	AKT1 AKT2 AKT3 C20orf97 CTMP KIAA0606 KIAA0931 MMAC1 NIPK PHLPP PHLPP1 PHLPP2 PHLPPL PKB PKBG PLEKHE1 PTEN RAC SCOP SKIP3 TEP1 THEM4 TRB3 TRIB3	Homo sapiens (human)
G alpha (12/13) signalling events	A-kinase anchor protein 13 Active breakpoint cluster region-related protein Alpha-1A adrenergic receptor Alpha-1B adrenergic receptor Alpha-1D adrenergic receptor Ephexin-1 FYVE, RhoGEF and PH domain-containing protein 1 FYVE, RhoGEF and PH domain-containing protein 2 FYVE, RhoGEF and PH domain-containing protein 3 FYVE, RhoGEF and PH domain-containing protein 4 Guanine nucleotide exchange factor DBS Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein subunit alpha-12 Guanine nucleotide-binding protein subunit alpha-13 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Intersectin-1 Kalirin Neuroepithelial cell-transforming gene 1 protein Obscurin Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Pleckstrin homology domain-containing family G member 2 Pleckstrin homology domain-containing family G member 5 Plexin-B1 Protein ECT2 Proto-oncogene DBL Proto-oncogene vav Ras-specific guanine nucleotide-releasing factor 2 Rho guanine nucleotide exchange factor 10-like protein Rho guanine nucleotide exchange factor 10 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 12 Rho guanine nucleotide exchange factor 15 Rho guanine nucleotide exchange factor 16 Rho guanine nucleotide exchange factor 17 Rho guanine nucleotide exchange factor 18 Rho guanine nucleotide exchange factor 19 Rho guanine nucleotide exchange factor 1 Rho guanine nucleotide exchange factor 26 Rho guanine nucleotide exchange factor 2 Rho guanine nucleotide exchange factor 33 Rho guanine nucleotide exchange factor 35 Rho guanine nucleotide exchange factor 37 Rho guanine nucleotide exchange factor 38 Rho guanine nucleotide exchange factor 39 Rho guanine nucleotide exchange factor 3 Rho guanine nucleotide exchange factor 40 Rho guanine nucleotide exchange factor 4 Rho guanine nucleotide exchange factor 5 Rho guanine nucleotide exchange factor 6 Rho guanine nucleotide exchange factor 7 Rho guanine nucleotide exchange factor 9 Rho guanine nucleotide exchange factor TIAM1 Rho guanine nucleotide exchange factor TIAM2 Rho-associated protein kinase 1 Rho-associated protein kinase 2 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoC Son of sevenless homolog 1 Son of sevenless homolog 2 Thromboxane A2 receptor Transforming protein RhoA Triple functional domain protein Tyrosine-protein kinase BTK	A1IGU5 A5YM69 A8MVX0 O14610 O14775 O14827 O15013 O15068 O15085 O43157 O43307 O60229 O60262 O75116 O75962 O94827 O94989 P08134 P10911 P15498 P16520 P21731 P25100 P35348 P35368 P50150 P50151 P52735 P59768 P61586 P61952 P62745 P62873 P62879 P63211 P63215 P63218 P98174 Q03113 Q06187 Q07889 Q07890 Q12774 Q12802 Q12979 Q13009 Q13464 Q14155 Q14344 Q15052 Q15811 Q5JSP0 Q5VST9 Q5VV41 Q6ZSZ5 Q7Z628 Q7Z6J4 Q8IVF5 Q8IW93 Q8N4T4 Q8N5V2 Q8TCU6 Q8TER5 Q92888 Q92974 Q96DR7 Q96M96 Q96PE2 Q9H7P9 Q9H8V3 Q9HAV0 Q9HCE6 Q9NR80 Q9NR81 Q9NXL2 Q9NZN5 Q9P2W3 Q9UBI6 Q9UK08 Q9UKW4	ABR ADRA1A ADRA1B ADRA1C ADRA1D AGMX1 AKAP13 ARH12 ARH6 ARH9 ARHA ARHB ARHC ARHDH9 ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF26 ARHGEF3 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF5L ARHGEF6 ARHGEF7 ARHGEF8 ARHGEF9 ATK BPK BRX BTK C9orf100 COOL1 COOL2 DBL DUET DUO ECT2 EPHEXIN4 FGD1 FGD2 FGD3 FGD4 FGDY FRABP GNA12 GNA13 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 GRF2 GRINCHGEF HAPIP HT31 ITSN ITSN1 KALRN KIAA0006 KIAA0142 KIAA0294 KIAA0337 KIAA0362 KIAA0380 KIAA0382 KIAA0407 KIAA0424 KIAA0521 KIAA0619 KIAA0651 KIAA0720 KIAA0915 KIAA1112 KIAA1415 KIAA1556 KIAA1626 KIAA1639 KIAA2016 LARG LBC LFP40 MCF2 MCF2L NBR NET1 NGEF OBSCN OST P85SPR PAK3BP PIXA PIXB PLEKHG2 PLEKHG5 PLXN5 PLXNB1 PREX1 RASGRF2 RHO12 RHOA RHOB RHOC ROCK1 ROCK2 SEP SGEF SH3D1A SOLO SOS1 SOS2 STEF TBXA2R TEM4 TIAM1 TIAM2 TIM TRAD TRIO VAV VAV1 VAV2 VAV3 ZFYVE3 ZFYVE4 ZFYVE5 ZFYVE6	Homo sapiens (human)
The activation of arylsulfatases	Arylsulfatase A Arylsulfatase B Arylsulfatase D Arylsulfatase F Arylsulfatase G Arylsulfatase H Arylsulfatase I Arylsulfatase J Arylsulfatase K Arylsulfatase L Formylglycine-generating enzyme Inactive C-alpha-formylglycine-generating enzyme 2 Steryl-sulfatase	P08842 P15289 P15848 P51689 P51690 P54793 Q5FYA8 Q5FYB0 Q5FYB1 Q6UWY0 Q8NBJ7 Q8NBK3 Q96EG1	ARSA ARSB ARSC1 ARSD ARSE ARSF ARSG ARSH ARSI ARSJ ARSK ARSL KIAA1001 STS SUMF1 SUMF2 TSULF	Homo sapiens (human)
Defective LFNG causes SCDO3	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe Neurogenic locus notch homolog protein 1 Neurogenic locus notch homolog protein 2 Neurogenic locus notch homolog protein 3 Neurogenic locus notch homolog protein 4	P46531 Q04721 Q8NES3 Q99466 Q9UM47	INT3 LFNG NOTCH1 NOTCH2 NOTCH3 NOTCH4 TAN1	Homo sapiens (human)
ALPK1 signaling pathway	Alpha-protein kinase 1 Mitogen-activated protein kinase kinase kinase 7 Polyubiquitin-B Polyubiquitin-C TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 TRAF-interacting protein with FHA domain-containing protein A Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O43318 P0CG47 P0CG48 P62979 P62987 Q15750 Q8N5C8 Q96CG3 Q96QP1 Q9NYJ8 Q9Y4K3	ALPK1 KIAA0733 KIAA1527 LAK MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 RNF85 RPS27A T2BP TAB1 TAB2 TAB3 TAK1 TIFA TRAF6 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Defective AHCY causes HMAHCHD	Adenosylhomocysteinase	P23526	AHCY SAHH	Homo sapiens (human)
PRC2 methylates histones and DNA	DNA (cytosine-5)-methyltransferase 1 DNA (cytosine-5)-methyltransferase 3A DNA (cytosine-5)-methyltransferase 3B Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 Metal-response element-binding transcription factor 2 PHD finger protein 19 PHD finger protein 1 Polycomb protein EED Polycomb protein SUZ12 Protein Jumonji Zinc finger protein AEBP2	O43189 O60814 O75530 P04908 P06899 P0C5Y9 P16104 P20671 P23527 P26358 P33778 P57053 P58876 P62805 P62807 P68431 P84243 Q09028 Q15022 Q15910 Q16576 Q16777 Q16778 Q5T6S3 Q6FI13 Q6ZN18 Q71DI3 Q71UI9 Q8N257 Q92833 Q93077 Q93079 Q96A08 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9UBC3 Q9Y483 Q9Y6K1	AEBP2 AIM CHET9 CXXC9 DNMT DNMT1 DNMT3A DNMT3B EED EZH2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 JARID2 JJAZ1 JMJ KIAA0160 KMT6 MTF2 PCL1 PCL2 PCL3 PHF1 PHF19 RBAP46 RBAP48 RBBP4 RBBP7 SUZ12 TSH2B	Homo sapiens (human)
ARMS-mediated activation	14-3-3 protein beta/alpha Adapter molecule crk Beta-nerve growth factor High affinity nerve growth factor receptor Kinase D-interacting substrate of 220 kDa Ras-related protein Rap-1A Serine/threonine-protein kinase B-raf	P01138 P04629 P15056 P31946 P46108 P62834 Q9ULH0	ARMS BRAF BRAF1 CRK KIAA1250 KIDINS220 KREV1 MTC NGF NGFB NTRK1 RAFB1 RAP1A TRK TRKA YWHAB	Homo sapiens (human)
Signaling by NODAL	Activin receptor type-1B Activin receptor type-1C Activin receptor type-2A Activin receptor type-2B Cerberus Cryptic protein DAN domain family member 5 Dr1-associated corepressor Embryonic growth/differentiation factor 1 Forkhead box protein H1 Forkhead box protein O3 Furin Left-right determination factor 1 Left-right determination factor 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Nodal homolog Proprotein convertase subtilisin/kexin type 6 Protein Cripto Putative protein CRIPTO3	O00292 O43524 O75593 O75610 O95813 P09958 P0CG37 P13385 P27037 P27361 P27539 P28482 P29122 P36896 P51864 P84022 Q13485 Q13705 Q14919 Q15796 Q8N907 Q8NER5 Q96S42	ACVR1B ACVR1C ACVR2 ACVR2A ACVR2B ACVRLK4 ALK4 ALK7 CER1 CER2 CFC1 CKTSF1B3 CRIPTO CRIPTO-1 CRIPTO-3 CRIPTO3 DAND4 DAND5 DPC4 DRAP1 EBAF ERK1 ERK2 FAST1 FAST2 FKHRL1 FOXH1 FOXO3 FOXO3A FUR FURIN GDF1 GREM3 LEFTA LEFTB LEFTY1 LEFTY2 LEFTYA LEFTYB MADH2 MADH3 MADH4 MADR2 MAPK1 MAPK3 NODAL PACE PACE4 PCSK3 PCSK6 PRKM1 PRKM2 PRKM3 SMAD2 SMAD3 SMAD4 SP1 TDGF1 TDGF1P3 TDGF2 TDGF3 TGFB4	Homo sapiens (human)
Ion homeostasis	ATP-binding cassette sub-family C member 9 ATP-sensitive inward rectifier potassium channel 11 Aspartyl/asparaginyl beta-hydroxylase Calcium release-activated calcium channel protein 1 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Cardiac phospholamban Chloride intracellular channel protein 2 FXYD domain-containing ion transport regulator 3 FXYD domain-containing ion transport regulator 4 FXYD domain-containing ion transport regulator 6 FXYD domain-containing ion transport regulator 7 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 Myotonin-protein kinase Nitric oxide synthase 1 Peptidyl-prolyl cis-trans isomerase FKBP1B Phospholemman Plasma membrane calcium-transporting ATPase 1 Plasma membrane calcium-transporting ATPase 2 Plasma membrane calcium-transporting ATPase 3 Plasma membrane calcium-transporting ATPase 4 Protein orai-2 Ryanodine receptor 1 Ryanodine receptor 2 Ryanodine receptor 3 S-adenosylhomocysteine hydrolase-like protein 1 Sarcolipin Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Short transient receptor potential channel 1 Sodium/calcium exchanger 1 Sodium/calcium exchanger 2 Sodium/calcium exchanger 3 Sodium/potassium-transporting ATPase subunit alpha-1 Sodium/potassium-transporting ATPase subunit alpha-2 Sodium/potassium-transporting ATPase subunit alpha-3 Sodium/potassium-transporting ATPase subunit alpha-4 Sodium/potassium-transporting ATPase subunit beta-1 Sodium/potassium-transporting ATPase subunit beta-2 Sodium/potassium-transporting ATPase subunit beta-3 Sodium/potassium-transporting ATPase subunit gamma Sorcin Stromal interaction molecule 1 Triadin Troponin I, cardiac muscle cAMP-dependent protein kinase catalytic subunit alpha	O00168 O00631 O14983 O15247 O43865 O60706 P05023 P05026 P0DP23 P13637 P14415 P16615 P17612 P19429 P20020 P21817 P23634 P26678 P29475 P30626 P32418 P48995 P50993 P54709 P54710 P57103 P58549 P59646 P68106 Q01814 Q09013 Q12797 Q13061 Q13554 Q13555 Q13557 Q13586 Q13733 Q14571 Q14573 Q14643 Q14654 Q14802 Q15413 Q16720 Q92736 Q93084 Q96D31 Q96SN7 Q9H0Q3 Q9UPR5 Q9UQM7	ABCC9 AHCYL1 ASPH ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1AL2 ATP1B ATP1B1 ATP1B2 ATP1B3 ATP1C ATP1G1 ATP2A1 ATP2A2 ATP2A3 ATP2B ATP2B1 ATP2B2 ATP2B3 ATP2B4 BAH C7orf19 CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CBCIP2 CLIC2 CNC CRACM1 DCAL DM1PK DMPK FKBP12.6 FKBP1B FKBP1L FKBP9 FXYD1 FXYD2 FXYD3 FXYD4 FXYD6 FXYD7 GOK HBRR INSP3R1 IRBIT ITPR1 ITPR2 ITPR3 KCNJ11 KIAA0778 KIAA0968 KIAA1087 MAT8 MDPK MXRA1 NCX1 NCX2 NCX3 NOS1 ORAI1 ORAI2 OTK4 PKACA PLB PLM PLML PLN PMCA1 PMCA2 PRKACA RYDR RYR1 RYR2 RYR3 SLC8A1 SLC8A2 SLC8A3 SLN SRI STIM1 SUR2 TMEM142A TMEM142B TNNC1 TNNI3 TRDN TRP1 TRPC1 XPVKONA	Homo sapiens (human)
DNA methylation	DNA (cytosine-5)-methyltransferase 1 DNA (cytosine-5)-methyltransferase 3-like DNA (cytosine-5)-methyltransferase 3A DNA (cytosine-5)-methyltransferase 3B E3 ubiquitin-protein ligase UHRF1 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4	O60814 P04908 P06899 P0C5Y9 P16104 P20671 P23527 P26358 P33778 P57053 P58876 P62805 P62807 P68431 P84243 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8N257 Q93077 Q93079 Q96A08 Q96T88 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9UBC3 Q9UJW3 Q9Y6K1	AIM CXXC9 DNMT DNMT1 DNMT3A DNMT3B DNMT3L H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 ICBP90 NP95 RNF106 TSH2B UHRF1	Homo sapiens (human)
BBSome-mediated cargo-targeting to cilium	ADP-ribosylation factor-like protein 6 BBSome complex assembly protein BBS10 BBSome complex member BBS1 BBSome complex member BBS2 BBSome complex member BBS4 BBSome complex member BBS5 BBSome complex member BBS7 BBSome-interacting protein 1 Chaperonin-containing T-complex member BBS12 Leucine zipper transcription factor-like protein 1 Melanin-concentrating hormone receptor 1 Molecular chaperone MKKS Protein PTHB1 Protein smoothened Rab-3A-interacting protein Somatostatin receptor type 3 T-complex protein 1 subunit alpha T-complex protein 1 subunit beta T-complex protein 1 subunit delta T-complex protein 1 subunit epsilon T-complex protein 1 subunit gamma T-complex protein 1 subunit theta Tetratricopeptide repeat protein 8	A8MTZ0 P17987 P32745 P48643 P49368 P50990 P50991 P78371 Q3SYG4 Q6ZW61 Q8IWZ6 Q8N3I7 Q8NFJ9 Q8TAM1 Q8TAM2 Q96QF0 Q96RK4 Q99705 Q99835 Q9BXC9 Q9H0F7 Q9NPJ1 Q9NQ48	99D8.1 ARL6 BBIP1 BBIP10 BBS1 BBS10 BBS12 BBS2 BBS2L1 BBS2L2 BBS3 BBS4 BBS5 BBS6 BBS7 BBS8 BBS9 C12orf58 C21orf112 C4orf24 CCT1 CCT2 CCT3 CCT4 CCT5 CCT8 CCTA CCTB CCTD CCTE CCTG CCTQ GPR24 KIAA0002 KIAA0098 LZTFL1 MCHR1 MKKS NCRNA00081 PTHB1 RAB3IP RABIN8 SLC1 SMO SMOH SRB SSTR3 TCP1 TRIC5 TTC8	Homo sapiens (human)
Mitotic Metaphase/Anaphase Transition	F-box only protein 5 Serine/threonine-protein kinase PLK1	P53350 Q9UKT4	EMI1 FBX5 FBXO5 PLK PLK1	Homo sapiens (human)
RHO GTPases activate PKNs	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 3-phosphoinositide-dependent protein kinase 1 M-phase inducer phosphatase 3 Myosin light polypeptide 6 Myosin regulatory light chain 12B Myosin regulatory light polypeptide 9 Myosin-10 Myosin-11 Myosin-14 Myosin-9 Protein phosphatase 1 regulatory subunit 12A Protein phosphatase 1 regulatory subunit 12B Protein phosphatase 1 regulatory subunit 14A Ras-related C3 botulinum toxin substrate 1 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoC Serine/threonine-protein kinase N1 Serine/threonine-protein kinase N2 Serine/threonine-protein kinase N3 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein phosphatase PP1-beta catalytic subunit Transforming protein RhoA	O14950 O14974 O15530 O60237 P08134 P24844 P27348 P30307 P31946 P31947 P35579 P35580 P35749 P60660 P61586 P61981 P62140 P62258 P62745 P63000 P63104 Q04917 Q13153 Q16512 Q16513 Q6P5Z2 Q7Z406 Q96A00	ARH12 ARH6 ARH9 ARHA ARHB ARHC CDC25C CPI17 HME1 KIAA0866 KIAA2034 MBS MLC2 MRLC1 MRLC2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLC2B MYPT1 MYPT2 MYRL2 PAK1 PDK1 PDPK1 PKN PKN1 PKN2 PKN3 PKNBETA PPP1CB PPP1INL PPP1R12A PPP1R12B PPP1R14A PRK1 PRK2 PRKCL1 PRKCL2 RAC1 RHO12 RHOA RHOB RHOC SFN TC25 YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	Homo sapiens (human)
Calcineurin activates NFAT	Calcineurin subunit B type 1 Calmodulin-1 Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 2 Nuclear factor of activated T-cells, cytoplasmic 3 Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase FKBP1A Protein phosphatase 3 catalytic subunit alpha Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	O95644 P0DP23 P16298 P62937 P62942 P63098 Q08209 Q12968 Q13469	CALM CALM1 CALNA CALNA2 CALNB CAM CAM1 CNA CNA2 CNB CYPA FKBP1 FKBP12 FKBP1A NFAT1 NFAT2 NFAT4 NFATC NFATC1 NFATC2 NFATC3 NFATP PPIA PPP3CA PPP3CB PPP3R1	Homo sapiens (human)

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