GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **1251 - 1275** of **2074** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator	O14920 O15111 Q9Y6K9	CHUK FIP3 IKBKB IKBKG IKKA IKKB NEMO TCF16	Homo sapiens (human)
IKBKB deficiency causes SCID	Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator	O14920 O15111 Q9Y6K9	CHUK FIP3 IKBKB IKBKG IKKA IKKB NEMO TCF16	Homo sapiens (human)
IFNG signaling activates MAPKs	Interferon gamma receptor 1 Interferon gamma receptor 2 Interferon gamma Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 RAF proto-oncogene serine/threonine-protein kinase Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2	O60674 P01579 P04049 P15260 P23458 P27361 P28482 P38484	ERK1 ERK2 IFNG IFNGR1 IFNGR2 IFNGT1 JAK1 JAK1A JAK1B JAK2 MAPK1 MAPK3 PRKM1 PRKM2 PRKM3 RAF RAF1	Homo sapiens (human)
Hypusinylation	Deoxyhypusine hydroxylase Deoxyhypusine synthase Eukaryotic translation initiation factor 5A-1 Eukaryotic translation initiation factor 5A-2	P49366 P63241 Q9BU89 Q9GZV4	DHPS DOHH DS EIF5A EIF5A2 HLRC1	Homo sapiens (human)
Hydroxycarboxylic acid-binding receptors	Hydroxycarboxylic acid receptor 1 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor 3	P49019 Q8TDS4 Q9BXC0	GPR104 GPR109A GPR109B GPR81 HCA1 HCA2 HCA3 HCAR1 HCAR2 HCAR3 HM74A HM74B NIACR1 NIACR2	Homo sapiens (human)
Hydrolysis of LPC	Cytosolic phospholipase A2 beta Cytosolic phospholipase A2 delta Cytosolic phospholipase A2 epsilon Cytosolic phospholipase A2 gamma Cytosolic phospholipase A2 zeta Cytosolic phospholipase A2 Glycerophosphocholine phosphodiesterase GPCPD1 Lysosomal phospholipase A and acyltransferase Phospholipase B-like 1	P0C869 P47712 Q3MJ16 Q68DD2 Q6P4A8 Q86XP0 Q8NCC3 Q9NPB8 Q9UP65	CPLA2 GDE5 GPCPD1 KIAA1434 LYPLA3 PLA2G15 PLA2G4 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLBD1	Homo sapiens (human)
Hyaluronan uptake and degradation	Beta-glucuronidase Beta-hexosaminidase subunit alpha Beta-hexosaminidase subunit beta CD44 antigen Calcineurin B homologous protein 1 Hyaluronan mediated motility receptor Hyaluronidase-1 Hyaluronidase-2 Hyaluronidase-3 Lymphatic vessel endothelial hyaluronic acid receptor 1 Sodium/hydrogen exchanger 1 Stabilin-2	O43820 O75330 P06865 P07686 P08236 P16070 P19634 Q12794 Q12891 Q8WWQ8 Q99653 Q9Y5Y7	APNH1 CD44 CHP CHP1 CRSBP1 FEEL2 FELL FEX2 GUSB HAR HARE HEXA HEXB HMMR HYAL1 HYAL2 HYAL3 IHABP LHR LUCA1 LUCA2 LUCA3 LYVE1 MDU2 MDU3 MIC4 NHE1 RHAMM SLC9A1 STAB2 XLKD1	Homo sapiens (human)	G35674CY
Hyaluronan biosynthesis and export	ATP-binding cassette sub-family C member 5 Cell migration-inducing and hyaluronan-binding protein Hyaluronan synthase 1 Hyaluronan synthase 2 Hyaluronan synthase 3	O00219 O15440 Q8WUJ3 Q92819 Q92839	ABCC5 CEMIP HAS HAS1 HAS2 HAS3 HYBID KIAA1199 MRP5	Homo sapiens (human)	G35674CY
HuR (ELAVL1) binds and stabilizes mRNA	Acidic leucine-rich nuclear phosphoprotein 32 family member A ELAV-like protein 1 Exportin-1 Nuclear pore complex protein Nup214 Protein SET Protein kinase C alpha type Protein kinase C delta type Tumor necrosis factor ligand superfamily member 13	O14980 O75888 P17252 P35658 P39687 Q01105 Q05655 Q15717	ANP32A APRIL C15orf1 CAIN CAN CRM1 ELAVL1 HUR KIAA0023 LANP MAPM NUP214 PHAP1 PKCA PKCD PRKACA PRKCA PRKCD SET TALL2 TNFSF13 XPO1 ZTNF2	Homo sapiens (human)
Hormone ligand-binding receptors	Follicle-stimulating hormone receptor Follitropin subunit beta Glycoprotein hormone alpha-2 Glycoprotein hormone beta-5 Glycoprotein hormones alpha chain Gonadotropin-releasing hormone receptor Lutropin subunit beta Lutropin-choriogonadotropic hormone receptor Progonadoliberin-1 Progonadoliberin-2 Putative gonadotropin-releasing hormone II receptor Thyrotropin receptor Thyrotropin subunit beta	O43555 P01148 P01215 P01222 P01225 P01229 P16473 P22888 P23945 P30968 Q86YW7 Q96P88 Q96T91	CGA FSHB FSHR GNRH GNRH1 GNRH2 GNRHR GNRHR2 GPA2 GPB5 GPHA2 GPHB5 GRH GRHR LCGR LGR1 LGR2 LGR3 LHB LHCGR LHRH LHRHR TSHB TSHR ZLUT1 ZSIG51	Homo sapiens (human)
Homologous DNA Pairing and Strand Exchange	26S proteasome complex subunit SEM1 BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA repair protein XRCC3 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin Partner and localizer of BRCA2 RAD51-associated protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Serine-protein kinase ATM	O15315 O43502 O43542 O43543 O60934 O75771 P38398 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q14191 Q86YC2 Q92878 Q92993 Q96B01 Q96E14 Q99708 Q99728 Q9BX63 Q9H9A7 Q9UQ84	ATM BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FANCN HEX1 HNGS1 HTATIP KAT5 KIAA0083 MRE11 MRE11A NBN NBS NBS1 P95 PALB2 PIR51 RAD50 RAD51 RAD51A RAD51AP1 RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RBBP8 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 RMI1 RMI2 RNF53 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A WRN XRCC2 XRCC3	Homo sapiens (human)
Histidine catabolism	Carnosine N-methyltransferase Carnosine synthase 1 Formimidoyltransferase-cyclodeaminase Histamine N-methyltransferase Histidine ammonia-lyase Histidine decarboxylase Probable imidazolonepropionase Urocanate hydratase	A5YM72 O95954 P19113 P42357 P50135 Q8N4J0 Q96N76 Q96NU7	AMDHD1 ATPGD1 C9orf41 CARNMT1 CARNS1 FTCD HAL HDC HIS HNMT KIAA1394 UROC1	Homo sapiens (human)
Histamine receptors	Histamine H1 receptor Histamine H2 receptor Histamine H3 receptor Histamine H4 receptor	P25021 P35367 Q9H3N8 Q9Y5N1	GPCR105 GPCR97 HRH1 HRH2 HRH3 HRH4	Homo sapiens (human)
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	Acetylcholine receptor subunit delta Acetylcholine receptor subunit epsilon Acetylcholine receptor subunit gamma Neuronal acetylcholine receptor subunit alpha-3 Neuronal acetylcholine receptor subunit alpha-4 Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit beta-4	P07510 P17787 P30926 P32297 P43681 Q04844 Q07001	ACHRD ACHRE ACHRG CHRNA3 CHRNA4 CHRNB2 CHRNB4 CHRND CHRNE CHRNG NACHRA3 NACRA4	Homo sapiens (human)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	Acetylcholine receptor subunit alpha Neuronal acetylcholine receptor subunit alpha-2 Neuronal acetylcholine receptor subunit alpha-3 Neuronal acetylcholine receptor subunit alpha-4 Neuronal acetylcholine receptor subunit alpha-5 Neuronal acetylcholine receptor subunit alpha-6 Neuronal acetylcholine receptor subunit alpha-7 Neuronal acetylcholine receptor subunit alpha-9 Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit beta-3 Neuronal acetylcholine receptor subunit beta-4	P02708 P17787 P30532 P30926 P32297 P36544 P43681 Q05901 Q15822 Q15825 Q9UGM1	ACHRA CHNRA CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 NACHRA3 NACHRA5 NACHRA7 NACHRA9 NACRA4	Homo sapiens (human)
Highly calcium permeable nicotinic acetylcholine receptors	Acetylcholine receptor subunit alpha Neuronal acetylcholine receptor subunit alpha-2 Neuronal acetylcholine receptor subunit alpha-3 Neuronal acetylcholine receptor subunit alpha-4 Neuronal acetylcholine receptor subunit alpha-5 Neuronal acetylcholine receptor subunit alpha-6 Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit beta-3 Neuronal acetylcholine receptor subunit beta-4	P02708 P17787 P30532 P30926 P32297 P43681 Q05901 Q15822 Q15825	ACHRA CHNRA CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNB2 CHRNB3 CHRNB4 NACHRA3 NACHRA5 NACRA4	Homo sapiens (human)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	3-phosphoinositide-dependent protein kinase 1 Adenylate cyclase type 1 Adenylate cyclase type 2 Adenylate cyclase type 3 Adenylate cyclase type 4 Adenylate cyclase type 5 Adenylate cyclase type 6 Adenylate cyclase type 7 Adenylate cyclase type 8 Adenylate cyclase type 9 Cadherin-5 Calcitonin gene-related peptide type 1 receptor Calmodulin-1 Calpain small subunit 1 Calpain small subunit 2 Calpain-2 catalytic subunit Catenin beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(q) subunit alpha Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Guanine nucleotide-binding protein subunit alpha-11 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Matrix metalloproteinase-14 Nitric oxide synthase 3 P2Y purinoceptor 2 Pannexin-1 Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Piezo-type mechanosensitive ion channel component 1 Platelet endothelial cell adhesion molecule Pro-adrenomedullin Proline-rich protein 5 RAC-alpha serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Receptor activity-modifying protein 2 Serine/threonine-protein kinase N2 Serine/threonine-protein kinase mTOR Talin-1 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Transient receptor potential cation channel subfamily V member 4 Tyrosine-protein kinase Fyn Vascular endothelial growth factor receptor 2 Vascular endothelial growth factor receptor 3 Vinculin cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit	O00329 O00459 O14610 O14775 O15530 O43306 O60262 O60266 O60503 O60895 O95622 P04632 P06241 P0DP23 P10644 P13861 P16284 P16520 P17612 P17655 P18206 P22612 P22694 P29474 P29992 P31321 P31323 P31749 P33151 P35222 P35318 P35916 P35968 P40145 P41231 P42336 P42338 P42345 P50148 P50150 P50151 P50281 P51828 P59768 P61952 P62873 P62879 P63092 P63211 P63215 P63218 P85299 Q08462 Q08828 Q16513 Q16602 Q5JWF2 Q6R327 Q8NFM4 Q92508 Q96L46 Q96RD7 Q9BPZ7 Q9BVC4 Q9HAV0 Q9HBA0 Q9P2W3 Q9UBI6 Q9UK08 Q9Y490	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADM AKT1 AM CALCRL CALM CALM1 CAM CAM1 CANPL2 CAPN2 CAPN4 CAPNS CAPNS1 CAPNS2 CDH5 CGRPR CTNNB CTNNB1 FAM38A FLK1 FLT4 FRAP FRAP1 FRAP2 FYN GA11 GAQ GBL GNA11 GNAQ GNAS GNAS1 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 GSP KDR KIAA0037 KIAA0233 KIAA0422 KIAA0511 KIAA0520 KIAA1027 KIAA1060 KIAA1999 LST8 MAPKAP1 MIP1 MLST8 MMP14 MRS1 MTOR NOS3 P2RU1 P2RY2 PANX1 PDK1 PDPK1 PECAM1 PIEZO1 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R2 PKACA PKB PKN2 PKR1 PKR2 PRK2 PRKACA PRKACB PRKACG PRKAR1 PRKAR1A PRKAR1B PRKAR2 PRKAR2A PRKAR2B PRKCL2 PROTOR1 PRR5 RAC RAFT1 RAMP2 RAPT1 RICTOR SIN1 TLN TLN1 TRPV4 TSE1 VCL VEGFR2 VEGFR3 VRL2 VROAC	Homo sapiens (human)
Hh mutants are degraded by ERAD	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Derlin-2 E3 ubiquitin-protein ligase synoviolin Endoplasmic reticulum lectin 1 Polyubiquitin-B Polyubiquitin-C Proteasomal ubiquitin receptor ADRM1 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Protein OS-9 Protein sel-1 homolog 1 Sonic hedgehog protein Transitional endoplasmic reticulum ATPase Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00231 O00232 O00487 O14818 O43242 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28066 P28070 P28072 P28074 P35998 P43686 P48556 P49720 P49721 P51665 P55072 P60896 P60900 P62191 P62195 P62333 P62979 P62987 Q13200 Q13438 Q15008 Q15465 Q16186 Q86TM6 Q96DZ1 Q99436 Q99460 Q9GZP9 Q9UBV2 Q9UNM6	ADRM1 C2orf30 C7orf76 DER2 DERL2 DSS1 ERLEC1 FLANA GP110 HC2 HC3 HC8 HC9 HEL-220 HEL-S-70 HRD1 HSPC KIAA0107 KIAA1810 LMPX LMPY MB1 MIP224 MOV34L MSS1 NU OS9 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RPS27A SEL1L SEM1 SHFDG1 SHFM1 SHH SUG1 SUG2 SYVN1 TBP1 TBP7 TRAP2 TSA305 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VCP X XTP3TPB Y Z	Homo sapiens (human)
Heme signaling	3'-5' exoribonuclease HELZ2 Apolipoprotein A-I Apolipoprotein B-100 Basic helix-loop-helix ARNT-like protein 1 C-type lectin domain family 1 member B CREB-binding protein CREB-regulated transcription coactivator 1 CREB-regulated transcription coactivator 2 CREB-regulated transcription coactivator 3 Chromodomain-helicase-DNA-binding protein 9 Circadian locomoter output cycles protein kaput Cyclic AMP-dependent transcription factor ATF-2 Exportin-1 F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 Heme oxygenase 1 Hemoglobin subunit alpha Hemoglobin subunit beta Histone acetyltransferase p300 Histone deacetylase 3 Histone-arginine methyltransferase CARM1 Lymphocyte antigen 96 Mediator of RNA polymerase II transcription subunit 1 Membrane-associated progesterone receptor component 2 Myocyte-specific enhancer factor 2C Myocyte-specific enhancer factor 2D NAD-dependent protein deacetylase sirtuin-1 Neuronal PAS domain-containing protein 2 Nuclear factor erythroid 2-related factor 2 Nuclear receptor ROR-alpha Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 6 Nuclear receptor corepressor 1 Nuclear receptor subfamily 1 group D member 1 Nuclear receptor-interacting protein 1 Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Proton-coupled folate transporter Retinoic acid receptor RXR-alpha Retinoic acid-induced protein 1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Toll-like receptor 4 Transcription factor MafK Transcription regulator protein BACH1 Trimethylguanosine synthase	O00206 O00327 O14867 O14980 O15173 O15379 O15516 O60675 O60907 O75376 P02647 P04114 P09601 P15336 P19793 P20393 P35398 P48552 P68871 P69905 Q06413 Q07869 Q09472 Q14686 Q14814 Q15596 Q15648 Q15788 Q16236 Q3L8U1 Q53ET0 Q6STE5 Q6UUV7 Q6UUV9 Q7Z5J4 Q86X55 Q92793 Q96EB6 Q96NT5 Q96RS0 Q99743 Q9BYK8 Q9BZK7 Q9P126 Q9UBK2 Q9Y6Y9	AIB3 APOA1 APOB ARC205 ARNTL ATF2 BACH1 BAF60C BHLHE5 BHLHE74 BHLHE75 BHLHE8 BHLHE9 BMAL1 CARM1 CBP CHD9 CLEC1B CLEC2 CLOCK CREB2 CREBBP CREBP1 CRM1 CRSP1 CRSP200 CRTC1 CRTC2 CRTC3 DG6 DRIP205 DRIP230 EAR1 EP300 ESOP1 G21 HBA1 HBA2 HBB HCA137 HCP1 HDAC3 HELZ2 HMOX1 HO HO1 HREV IRA1 KIAA0181 KIAA0308 KIAA0334 KIAA0616 KIAA1047 KIAA1769 KIAA1820 KISH2 LEM6 LY96 MAFK MD2 MECT1 MED1 MEF2C MEF2D MOP3 MOP4 NCOA1 NCOA2 NCOA6 NCOA6IP NCOR1 NFE2L2 NPAS2 NR1C1 NR1D1 NR1F1 NR2B1 NRF2 NRIP1 P300 PASD3 PASD4 PBP PCFT PGC1 PGC1A PGRMC2 PIMT PMBP PPAR PPARA PPARBP PPARGBP PPARGC1 PPARGC1A PRIC285 PRIC320 PRMT4 RAI1 RAP250 RB18A RORA RXRA RZRA SIR2L1 SIRT1 SLC46A1 SMARCD3 SRC1 SRC2 TBL1 TBL1X TBL1XR1 TBLR1 TGS1 THRAL TIF2 TLR4 TORC1 TORC2 TORC3 TRAP220 TRBP TRIP2 WAMTP1 XPO1	Homo sapiens (human)
Heme degradation	ATP-binding cassette sub-family C member 2 Albumin Beta-glucuronidase Biliverdin reductase A Broad substrate specificity ATP-binding cassette transporter ABCG2 Fatty acid-binding protein, liver Flavin reductase (NADPH) Glutathione S-transferase A1 Heme oxygenase 1 Heme oxygenase 2 Multidrug resistance-associated protein 1 Solute carrier organic anion transporter family member 1B1 Solute carrier organic anion transporter family member 1B3 UDP-glucuronosyltransferase 1A1 UDP-glucuronosyltransferase 1A4	P02768 P07148 P08263 P09601 P22309 P22310 P30043 P30519 P33527 P53004 Q8VNV4 Q92887 Q9NPD5 Q9UNQ0 Q9Y6L6	ABCC1 ABCC2 ABCG2 ABCP ALB BCRP BCRP1 BLVR BLVRA BLVRB BVR CMOAT CMOAT1 CMRP FABP1 FABPL FLR GNT1 GSTA1 HMOX1 HMOX2 HO HO1 HO2 LST1 LST2 MRP MRP1 MRP2 MXR OATP1B1 OATP1B3 OATP2 OATP8 OATPC SCAN SLC21A6 SLC21A8 SLCO1B1 SLCO1B3 UGT1 UGT1A1 UGT1A4	Homo sapiens (human)
Heme biosynthesis	5-aminolevulinate synthase, erythroid-specific, mitochondrial 5-aminolevulinate synthase, non-specific, mitochondrial Albumin Broad substrate specificity ATP-binding cassette transporter ABCG2 Delta-aminolevulinic acid dehydratase Ferrochelatase, mitochondrial Heme A synthase COX15 Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial Porphobilinogen deaminase Protoheme IX farnesyltransferase, mitochondrial Protoporphyrinogen oxidase Uroporphyrinogen decarboxylase Uroporphyrinogen-III synthase	P02768 P06132 P08397 P10746 P13196 P13716 P22557 P22830 P36551 P50336 Q12887 Q7KZN9 Q9UNQ0	ABCG2 ABCP ALAD ALAS1 ALAS2 ALAS3 ALASE ALASH ALB ASB BCRP BCRP1 COX10 COX15 CPO CPOX CPX FECH HMBS MXR PBGD PPOX UPS UROD UROS	Homo sapiens (human)
Hedgehog ligand biogenesis	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Derlin-2 Desert hedgehog protein E3 ubiquitin-protein ligase synoviolin Endoplasmic reticulum lectin 1 Indian hedgehog protein Polyubiquitin-B Polyubiquitin-C Proteasomal ubiquitin receptor ADRM1 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Protein OS-9 Protein disulfide-isomerase Protein sel-1 homolog 1 Protein-cysteine N-palmitoyltransferase HHAT Sonic hedgehog protein Transitional endoplasmic reticulum ATPase Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00231 O00232 O00487 O14818 O43242 O43323 P07237 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28066 P28070 P28072 P28074 P35998 P43686 P48556 P49720 P49721 P51665 P55072 P60896 P60900 P62191 P62195 P62333 P62979 P62987 Q13200 Q13438 Q14623 Q15008 Q15465 Q16186 Q5VTY9 Q86TM6 Q96DZ1 Q99436 Q99460 Q9GZP9 Q9UBV2 Q9UNM6	ADRM1 C2orf30 C7orf76 DER2 DERL2 DHH DSS1 ERBA2L ERLEC1 FLANA GP110 HC2 HC3 HC8 HC9 HEL-220 HEL-S-70 HHAT HRD1 HSPC IHH KIAA0107 KIAA1810 LMPX LMPY MART2 MB1 MIP224 MOV34L MSS1 NU OS9 P4HB PDI PDIA1 PFAAP4 PO4DB POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RPS27A SEL1L SEM1 SHFDG1 SHFM1 SHH SKI1 SUG1 SUG2 SYVN1 TBP1 TBP7 TRAP2 TSA305 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VCP X XTP3TPB Y Z	Homo sapiens (human)
Hedgehog 'on' state	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cilium assembly protein DZIP1 Cullin-3 Desert hedgehog protein E3 ubiquitin-protein ligase Itchy homolog E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase SMURF1 E3 ubiquitin-protein ligase SMURF2 EvC complex member EVC G-protein coupled receptor 161 Indian hedgehog protein Kinesin-like protein KIF7 Limbin Parafibromin Polyubiquitin-B Polyubiquitin-C Proteasomal ubiquitin receptor ADRM1 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Protein numb homolog Protein patched homolog 1 Protein smoothened Serine/threonine-protein kinase ULK3 Sonic hedgehog protein Speckle-type POZ protein-like Speckle-type POZ protein Suppressor of fused homolog Transcriptional activator GLI3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Zinc finger protein GLI1 Zinc finger protein GLI2	O00231 O00232 O00487 O14818 O43242 O43323 O43791 P08151 P0CG47 P0CG48 P10070 P10071 P17980 P20618 P25786 P25787 P25788 P25789 P28066 P28070 P28072 P28074 P35998 P43686 P48556 P49720 P49721 P49757 P51665 P57679 P60896 P60900 P62191 P62195 P62333 P62877 P62979 P62987 Q13200 Q13618 Q13635 Q14623 Q15008 Q15465 Q16186 Q2M1P5 Q6IQ16 Q6P1J9 Q6PHR2 Q86UK5 Q86YF9 Q8N6U8 Q96J02 Q99436 Q99460 Q99835 Q9HAU4 Q9HCE7 Q9UMX1 Q9UNM6	ADRM1 C14orf41 C1orf28 C7orf76 CDC73 CUL3 DHH DSS1 DZIP DZIP1 DZIP2 EVC EVC2 GLI GLI1 GLI2 GLI3 GP110 GPR161 HC2 HC3 HC8 HC9 HRPT2 HSPC IHH ITCH KIAA0107 KIAA0617 KIAA0996 KIAA1625 KIF7 LBN LMPX LMPY MB1 MIP224 MOV34L MSS1 NU NUMB PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTCH PTCH1 RBX1 RNF75 ROC1 RPS27A SEM1 SHFDG1 SHFM1 SHH SMO SMOH SMURF1 SMURF2 SPOP SPOPL SUFU SUG1 SUG2 TBP1 TBP7 THP TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 ULK3 X Y Z	Homo sapiens (human)
Hedgehog 'off' state	Adenylate cyclase type 10 Adenylate cyclase type 1 Adenylate cyclase type 2 Adenylate cyclase type 3 Adenylate cyclase type 4 Adenylate cyclase type 5 Adenylate cyclase type 6 Adenylate cyclase type 7 Adenylate cyclase type 8 Adenylate cyclase type 9 Centriole and centriolar satellite protein OFD1 Cytoplasmic dynein 2 heavy chain 1 G-protein coupled receptor 161 Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Intraflagellar transport protein 122 homolog Intraflagellar transport protein 140 homolog Intraflagellar transport protein 172 homolog Intraflagellar transport protein 52 homolog Intraflagellar transport protein 57 homolog Intraflagellar transport protein 88 homolog Kinesin-like protein KIF3A Kinesin-like protein KIF7 Protein fantom Protein fuzzy homolog Protein inturned Protein patched homolog 1 Protein smoothened Suppressor of fused homolog Tectonic-like complex member MKS1 Tetratricopeptide repeat protein 21B Transcriptional activator GLI3 Tubby-related protein 3 WD repeat-containing protein 19 WD repeat-containing protein 35 Zinc finger protein GLI1 Zinc finger protein GLI2 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit	O43306 O60266 O60503 O75386 O75665 O95622 P08151 P10070 P10071 P10644 P13861 P17612 P22612 P22694 P31321 P31323 P40145 P51828 P63092 Q08462 Q08828 Q13099 Q13635 Q2M1P5 Q5JWF2 Q68CZ1 Q7Z4L5 Q8N6U8 Q8NCM8 Q8NEZ3 Q8NFM4 Q96PN6 Q96RY7 Q99835 Q9BT04 Q9HBG6 Q9NWB7 Q9NXB0 Q9P2L0 Q9UG01 Q9ULD6 Q9UMX1 Q9Y366 Q9Y496	ADCY1 ADCY10 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 C20orf9 CXorf5 DERP8 DHC1B DHC2 DNCH2 DYH1B DYNC2H1 ESRRBL1 FTM FUZ FY GLI GLI1 GLI2 GLI3 GNAS GNAS1 GPR161 GSP HIPPI IFT121 IFT122 IFT139 IFT140 IFT144 IFT172 IFT52 IFT57 IFT88 INTU KIAA0037 KIAA0422 KIAA0511 KIAA0520 KIAA0590 KIAA1005 KIAA1060 KIAA1179 KIAA1284 KIAA1336 KIAA1638 KIAA1992 KIAA1997 KIF3 KIF3A KIF7 MKS1 NGD5 NPHP8 OFD1 PDZD6 PDZK6 PKACA PKR1 PKR2 PRKACA PRKACB PRKACG PRKAR1 PRKAR1A PRKAR1B PRKAR2 PRKAR2A PRKAR2B PTCH PTCH1 RPGRIP1L SAC SMO SMOH SPG SUFU TG737 THP TSE1 TTC10 TTC21B TUBL3 TULP3 WDR10 WDR140 WDR19 WDR35 WDTC2	Homo sapiens (human)
HSP90 chaperone cycle for SHRs	Actin-related protein 10 Alpha-centractin Androgen receptor Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoplasmic dynein 1 light intermediate chain 1 Cytoplasmic dynein 1 light intermediate chain 2 DnaJ homolog subfamily A member 1 DnaJ homolog subfamily A member 2 DnaJ homolog subfamily A member 4 DnaJ homolog subfamily B member 1 Dynactin subunit 1 Dynactin subunit 2 Dynactin subunit 3 Dynactin subunit 4 Dynactin subunit 5 Dynactin subunit 6 Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic F-actin-capping protein subunit alpha-1 F-actin-capping protein subunit alpha-2 F-actin-capping protein subunit alpha-3 F-actin-capping protein subunit beta Glucocorticoid receptor Heat shock 70 kDa protein 1-like Heat shock 70 kDa protein 1A Heat shock 70 kDa protein 1B Heat shock cognate 71 kDa protein Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Heat shock-related 70 kDa protein 2 Mineralocorticoid receptor Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP5 Progesterone receptor Prostaglandin E synthase 3 Stress-induced-phosphoprotein 1	O00399 O14576 O43237 O60884 O75935 P04150 P06401 P07900 P08235 P08238 P0DMV8 P0DMV9 P10275 P11142 P25685 P31689 P31948 P34931 P47755 P47756 P52907 P54652 P61163 P63167 Q02790 Q13409 Q13451 Q13561 Q14203 Q14204 Q15185 Q8WW22 Q96FJ2 Q96KX2 Q9BTE1 Q9NZ32 Q9UJW0 Q9Y6G9	ACTR10 ACTR11 ACTR1A AIG6 AR ARP10 ARP11 CAPAA3 CAPZA1 CAPZA2 CAPZA3 CAPZB CPR3 CTRN1 DCTN1 DCTN2 DCTN22 DCTN3 DCTN4 DCTN5 DCTN50 DCTN6 DHC1 DHTR DLC1 DLC2 DNAJ1 DNAJ2 DNAJA1 DNAJA2 DNAJA4 DNAJB1 DNCH1 DNCI1 DNCI2 DNCIC1 DNCIC2 DNCL DNCL1 DNCLC1 DNCLI1 DNCLI2 DNECL DYHC DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 FKBP4 FKBP5 FKBP51 FKBP52 GRL GSG3 HDJ1 HDJ2 HDLC1 HIRIP4 HSC70 HSJ2 HSP72 HSP73 HSP90A HSP90AA1 HSP90AB1 HSP90B HSPA1 HSPA10 HSPA1A HSPA1B HSPA1L HSPA2 HSPA8 HSPC1 HSPC2 HSPC3 HSPCA HSPCB HSPF1 HSPF4 HSX70 KIAA0325 LIC2 MCR MLR NR3C1 NR3C2 NR3C3 NR3C4 P23 PGR PTGES3 STIP1 TEBP WS3	Homo sapiens (human)

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