GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **751 - 775** of **2090** in total

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Pathway Name	Protein Name	UniProt ID ▼	Gene Symbol
RAS signaling downstream of NF1 loss-of-function variants	GTPase HRas GTPase NRas Neurofibromin Sprouty-related, EVH1 domain-containing protein 1 Sprouty-related, EVH1 domain-containing protein 2 Sprouty-related, EVH1 domain-containing protein 3	P01111 P01112 P21359 Q2MJR0 Q7Z698 Q7Z699	EVE-3 HRAS HRAS1 NF1 NRAS SPRED1 SPRED2 SPRED3
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Adapter molecule crk Breast cancer anti-estrogen resistance protein 1 Dedicator of cytokinesis protein 1 Engulfment and cell motility protein 1 Engulfment and cell motility protein 2 GTPase HRas GTPase NRas Paxillin Protein-tyrosine kinase 6 Ras GTPase-activating protein 1 Ras-related C3 botulinum toxin substrate 1 Rho GTPase-activating protein 35 Transforming protein RhoA	P01111 P01112 P20936 P46108 P49023 P56945 P61586 P63000 Q13882 Q14185 Q92556 Q96JJ3 Q9NRY4	ARH12 ARHA ARHGAP35 BCAR1 BRK CAS CASS1 CED12A CRK CRKAS DOCK1 ELMO1 ELMO2 GAP GRF1 GRLF1 HRAS HRAS1 KIAA0281 KIAA1722 KIAA1834 NRAS P190A PTK6 PXN RAC1 RASA RASA1 RHO12 RHOA TC25 p190ARHOGAP
Activated NTRK3 signals through RAS	GTPase HRas GTPase NRas NT-3 growth factor receptor Neurotrophin-3 Son of sevenless homolog 1	P01111 P01112 P20783 Q07889 Q16288	HRAS HRAS1 NRAS NTF3 NTRK3 SOS1 TRKC
Signaling by FGFR4 in disease	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 GRB2-associated-binding protein 1 GTPase HRas GTPase NRas Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Son of sevenless homolog 1	P01111 P01112 P19174 P22455 P27986 P42336 Q07889 Q13480 Q8WU20	FGFR4 FRS2 GAB1 GRB1 HRAS HRAS1 JTK2 NRAS PIK3CA PIK3R1 PLC1 PLCG1 SOS1 TKF
Signaling by FLT3 fusion proteins	Cyclin-dependent kinase inhibitor 1 GRB2-associated-binding protein 2 GTPase HRas GTPase NRas Golgin subfamily B member 1 NADPH oxidase 4 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Serine/threonine-protein kinase pim-1 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Son of sevenless homolog 1 Spectrin beta chain, non-erythrocytic 1 Thyroid receptor-interacting protein 11 Transcription factor ETV6 Unconventional myosin-XVIIIa Zinc finger MYM-type protein 2	P01111 P01112 P11309 P27986 P38936 P41212 P42229 P42336 P51692 Q01082 Q07889 Q14789 Q15643 Q92614 Q9NPH5 Q9UBW7 Q9UQC2	CAP20 CD245 CDKN1 CDKN1A CEV14 CIP1 ETV6 FIM GAB2 GOLGB1 GRB1 HRAS HRAS1 KIAA0216 KIAA0571 MDA6 MYO18A MYSPDZ NOX4 NRAS PIC1 PIK3CA PIK3R1 PIM1 RAMP RENOX SDI1 SOS1 SPTB2 SPTBN1 STAT5 STAT5A STAT5B TEL TEL1 TIAF1 TRIP11 WAF1 ZMYM2 ZNF198
MET activates RAS signaling	GTPase HRas GTPase NRas Hepatocyte growth factor receptor Hepatocyte growth factor Mucin-20 Ran-binding protein 10 Ran-binding protein 9 Son of sevenless homolog 1	P01111 P01112 P08581 P14210 Q07889 Q6VN20 Q8N307 Q96S59	HGF HPTA HRAS HRAS1 KIAA1359 KIAA1464 MET MUC20 NRAS RANBP10 RANBP9 RANBPM SOS1
Constitutive Signaling by Overexpressed ERBB2	Erbin GTPase HRas GTPase NRas Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Receptor tyrosine-protein kinase erbB-2 SHC-transforming protein 1 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 12	P01111 P01112 P04626 P07900 P29353 Q05209 Q07889 Q16543 Q96RT1	CDC37 CDC37A ERBB2 ERBB2IP ERBIN HER2 HRAS HRAS1 HSP90A HSP90AA1 HSPC1 HSPCA KIAA1225 LAP2 MLN19 NEU NGL NRAS PTPN12 SHC SHC1 SHCA SOS1
Negative regulation of MAPK pathway	14-3-3 protein beta/alpha BRCA1-associated protein Dual specificity protein phosphatase 10 Dual specificity protein phosphatase 16 Dual specificity protein phosphatase 1 Dual specificity protein phosphatase 2 Dual specificity protein phosphatase 4 Dual specificity protein phosphatase 5 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Dual specificity protein phosphatase 8 Dual specificity protein phosphatase 9 GTPase HRas GTPase NRas Kinase suppressor of Ras 1 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylethanolamine-binding protein 1 Polyubiquitin-B Polyubiquitin-C Progestin and adipoQ receptor family member 3 RAF proto-oncogene serine/threonine-protein kinase Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase 5 Tyrosine-protein phosphatase non-receptor type 3 Tyrosine-protein phosphatase non-receptor type 7 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P01111 P01112 P04049 P0CG47 P0CG48 P10398 P15056 P26045 P27361 P27448 P28482 P28562 P30086 P30153 P30154 P31946 P35236 P53041 P53778 P62714 P62979 P62987 P67775 Q05923 Q13115 Q13202 Q13362 Q14738 Q15172 Q15173 Q16537 Q16690 Q16828 Q16829 Q6TCH7 Q7Z569 Q8IVT5 Q99956 Q9BY84 Q9Y6W6	ARAF ARAF1 BRAF BRAF1 BRAP C11orf81 CL100 CTAK1 DUSP1 DUSP10 DUSP16 DUSP2 DUSP4 DUSP5 DUSP6 DUSP7 DUSP8 DUSP9 EMK2 ERK1 ERK2 ERK6 HRAS HRAS1 KIAA0044 KIAA1700 KSR KSR1 MAPK1 MAPK12 MAPK3 MARK3 MKP1 MKP2 MKP3 MKP4 MKP5 MKP7 NRAS PAC1 PAQR3 PBP PEBP PEBP1 PKS PKS2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPP5 PPP5C PRKM1 PRKM2 PRKM3 PTPH1 PTPN10 PTPN3 PTPN7 PYST1 PYST2 RAF RAF1 RAFB1 RNF52 RPS27A SAPK3 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VH1 VH2 VH3 VH5 YWHAB
Signaling by high-kinase activity BRAF mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Beta-arrestin-1 Beta-arrestin-2 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylethanolamine-binding protein 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Vinculin von Willebrand factor	P01111 P01112 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q6VAB6 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 KIAA0051 KIAA0902 KIAA1027 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 NRAS PBP PEBP PEBP1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RIAM SRC SRC1 TLN TLN1 VCL VWF YWHAB
MAP2K and MAPK activation	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Beta-arrestin-1 Beta-arrestin-2 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Interleukin-17 receptor D Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylethanolamine-binding protein 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Vinculin WD repeat domain-containing protein 83 von Willebrand factor	P01111 P01112 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q6VAB6 Q7Z5R6 Q8IVT5 Q8NFM7 Q8WXI2 Q969H4 Q9BRX9 Q9UHA4 Q9Y2Q5 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IL17RD IL17RLM IQGAP1 ITGA2B ITGAB ITGB3 KIAA0051 KIAA0902 KIAA1027 KREV1 KSR KSR1 KSR2 LAMTOR2 LAMTOR3 MAP2K1 MAP2K1IP1 MAP2K2 MAPBPIP MAPK1 MAPK3 MAPKSP1 MARK3 MEK1 MEK2 MKK2 MORG1 NRAS PBP PEBP PEBP1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RIAM ROBLD3 SEF SRC SRC1 TLN TLN1 VCL VWF WDR83 YWHAB
SHC-related events triggered by IGF1R	GTPase HRas GTPase NRas Insulin-like growth factor 1 receptor Insulin-like growth factor I Insulin-like growth factor II Son of sevenless homolog 1	P01111 P01112 P01344 P05019 P08069 Q07889	HRAS HRAS1 IBP1 IGF1 IGF1R IGF2 NRAS SOS1
Insulin receptor signalling cascade	GTPase HRas GTPase NRas Growth factor receptor-bound protein 10 Insulin receptor Insulin SHC-transforming protein 1 Son of sevenless homolog 1	P01111 P01112 P01308 P06213 P29353 Q07889 Q13322	GRB10 GRBIR HRAS HRAS1 INS INSR KIAA0207 NRAS SHC SHC1 SHCA SOS1
Signalling to RAS	Beta-nerve growth factor GTPase HRas GTPase NRas High affinity nerve growth factor receptor SHC-transforming protein 1 SHC-transforming protein 2 SHC-transforming protein 3 Son of sevenless homolog 1	P01111 P01112 P01138 P04629 P29353 P98077 Q07889 Q92529	HRAS HRAS1 MTC NGF NGFB NRAS NSHC NTRK1 SCK SHC SHC1 SHC2 SHC3 SHCA SHCB SHCC SOS1 TRK TRKA
Signaling by RAS GTPase mutants	GTPase HRas GTPase KRas GTPase NRas	P01111 P01112 P01116	HRAS HRAS1 KRAS KRAS2 NRAS RASK2
Signaling by RAS GAP mutants	GTPase HRas GTPase KRas GTPase NRas	P01111 P01112 P01116	HRAS HRAS1 KRAS KRAS2 NRAS RASK2
Binding of TCF/LEF:CTNNB1 to target gene promoters	Axin-2 Catenin beta-1 Lymphoid enhancer-binding factor 1 Myc proto-oncogene protein Runt-related transcription factor 3 Transcription factor 7-like 1 Transcription factor 7-like 2 Transcription factor 7	P01106 P35222 P36402 Q13761 Q9HCS4 Q9NQB0 Q9UJU2 Q9Y2T1	AML2 AXIN2 BHLHE39 CBFA3 CTNNB CTNNB1 LEF1 MYC PEBP2A3 RUNX3 TCF1 TCF3 TCF4 TCF7 TCF7L1 TCF7L2
RUNX3 regulates WNT signaling	Catenin beta-1 G1/S-specific cyclin-D1 Lymphoid enhancer-binding factor 1 Myc proto-oncogene protein Runt-related transcription factor 3 Transcription factor 7-like 1 Transcription factor 7-like 2 Transcription factor 7	P01106 P24385 P35222 P36402 Q13761 Q9HCS4 Q9NQB0 Q9UJU2	AML2 BCL1 BHLHE39 CBFA3 CCND1 CTNNB CTNNB1 LEF1 MYC PEBP2A3 PRAD1 RUNX3 TCF1 TCF3 TCF4 TCF7 TCF7L1 TCF7L2
Transcription of E2F targets under negative control by DREAM complex	Cell division control protein 6 homolog DNA topoisomerase 2-alpha Histone deacetylase 1 Histone-binding protein RBBP4 M-phase inducer phosphatase 1 Myc proto-oncogene protein Proliferating cell nuclear antigen Protein lin-37 homolog Protein lin-52 homolog Protein lin-54 homolog Protein lin-9 homolog Protein max Retinoblastoma-like protein 1 Retinoblastoma-like protein 2 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F4 Transcription factor E2F5	P01106 P11388 P12004 P28749 P30304 P61244 Q01094 Q08999 Q09028 Q13547 Q14186 Q14188 Q15329 Q16254 Q52LA3 Q5TKA1 Q6MZP7 Q96GY3 Q99741	BARA BHLHD4 BHLHE39 C14orf46 CDC18L CDC25A CDC6 CXCDC1 DP1 DP2 E2F1 E2F4 E2F5 HDAC1 KIAA2037 LIN37 LIN52 LIN54 LIN9 MAX MYC PCNA RB2 RBAP48 RBBP3 RBBP4 RBL1 RBL2 RPD3L1 TFDP1 TFDP2 TGS TOP2 TOP2A
Cyclin A:Cdk2-associated events at S phase entry	CDK-activating kinase assembly factor MAT1 CDK5 and ABL1 enzyme substrate 1 Cyclin-A1 Cyclin-A2 Cyclin-H Cyclin-dependent kinase 2 Cyclin-dependent kinase 7 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Fizzy-related protein homolog Histone-binding protein RBBP4 M-phase inducer phosphatase 1 M-phase inducer phosphatase 2 Myc proto-oncogene protein Protein lin-37 homolog Protein lin-52 homolog Protein lin-54 homolog Protein lin-9 homolog Protein max RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Retinoblastoma-associated protein Retinoblastoma-like protein 2 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F4 Transcription factor E2F5 Wee1-like protein kinase	P01106 P06400 P20248 P24941 P30291 P30304 P30305 P31749 P31751 P38936 P46527 P50613 P51946 P51948 P61244 P78396 Q01094 Q08999 Q09028 Q14186 Q14188 Q15329 Q16254 Q52LA3 Q5TKA1 Q6MZP7 Q8TDN4 Q96GY3 Q9UM11 Q9Y243	AKT1 AKT2 AKT3 BARA BHLHD4 BHLHE39 C14orf46 CABLES CABLES1 CAK CAK1 CAP20 CAP35 CCN1 CCNA CCNA1 CCNA2 CCNH CDC25A CDC25B CDC25HU2 CDH1 CDK2 CDK7 CDKN1 CDKN1A CDKN1B CDKN2 CDKN7 CIP1 CXCDC1 DP1 DP2 E2F1 E2F4 E2F5 FYR FZR FZR1 KIAA1242 KIAA2037 KIP1 LIN37 LIN52 LIN54 LIN9 MAT1 MAX MDA6 MNAT1 MO15 MYC PIC1 PKB PKBG RAC RB1 RB2 RBAP48 RBBP3 RBBP4 RBL2 RNF66 SDI1 STK1 TFDP1 TFDP2 TGS WAF1 WEE1 p27
TFAP2 (AP-2) family regulates transcription of cell cycle factors	Cyclin-dependent kinase inhibitor 1 Lysine-specific demethylase 5B Myc proto-oncogene protein Transcription factor AP-2 gamma Transcription factor AP-2-alpha	P01106 P05549 P38936 Q92754 Q9UGL1	AP2TF BHLHE39 CAP20 CDKN1 CDKN1A CIP1 JARID1B KDM5B MDA6 MYC PIC1 PLU1 RBBP2H1 SDI1 TFAP2 TFAP2A TFAP2C WAF1
Activation of the AP-1 family of transcription factors	Cyclic AMP-dependent transcription factor ATF-2 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Protein c-Fos Transcription factor Jun	P01100 P05412 P15336 P27361 P28482 P45983 P45984 P53779 Q15759 Q16539	ATF2 CREB2 CREBP1 CSBP CSBP1 CSBP2 CSPB1 ERK1 ERK2 FOS G0S7 JNK1 JNK2 JNK3 JNK3A JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MXI2 PRKM1 PRKM10 PRKM11 PRKM2 PRKM3 PRKM8 PRKM9 SAPK1 SAPK1A SAPK1B SAPK1C SAPK2 SAPK2A SAPK2B
Terminal pathway of complement	Clusterin Complement C5 Complement component C6 Complement component C7 Complement component C8 alpha chain Complement component C8 beta chain Complement component C8 gamma chain Complement component C9	P01031 P02748 P07357 P07358 P07360 P10643 P10909 P13671	APOJ C5 C6 C7 C8A C8B C8G C9 CLI CLU CPAMD4 KUB1
Erythrocytes take up oxygen and release carbon dioxide	Ammonium transporter Rh type A Aquaporin-1 Band 3 anion transport protein Carbonic anhydrase 1 Carbonic anhydrase 2 Carbonic anhydrase 4 Hemoglobin subunit alpha Hemoglobin subunit beta	P00915 P00918 P02730 P22748 P29972 P68871 P69905 Q02094	AE1 AQP1 CA1 CA2 CA4 CHIP28 DI EPB3 HBA1 HBA2 HBB RH50 RHAG SLC4A1
Erythrocytes take up carbon dioxide and release oxygen	Ammonium transporter Rh type A Aquaporin-1 Band 3 anion transport protein Carbonic anhydrase 1 Carbonic anhydrase 2 Carbonic anhydrase 4 Cytochrome b5 reductase 4 Hemoglobin subunit alpha Hemoglobin subunit beta NADH-cytochrome b5 reductase 1 NADH-cytochrome b5 reductase 2 NADH-cytochrome b5 reductase-like	P00915 P00918 P02730 P22748 P29972 P68871 P69905 Q02094 Q6BCY4 Q6IPT4 Q7L1T6 Q9UHQ9	AE1 AQP1 CA1 CA2 CA4 CHIP28 CYB5R1 CYB5R2 CYB5R4 CYB5RL DI EPB3 HBA1 HBA2 HBB NCB5OR NQO3A2 RH50 RHAG SLC4A1
Defective ADA disrupts (deoxy)adenosine deamination	Adenosine deaminase	P00813	ADA ADA1

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