GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **76 - 100** of **2090** in total

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Pathway Name	Protein Name ▲	UniProt ID	Gene Symbol
TP53 Regulates Metabolic Genes	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 Cellular tumor antigen p53 Cytochrome c oxidase assembly protein COX11, mitochondrial Cytochrome c oxidase assembly protein COX14 Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial Cytochrome c oxidase assembly protein COX18, mitochondrial Cytochrome c oxidase assembly protein COX19 Cytochrome c oxidase assembly protein COX20, mitochondrial Cytochrome c oxidase subunit 1 Cytochrome c oxidase subunit 2 Cytochrome c oxidase subunit 3 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase subunit 5B, mitochondrial Cytochrome c oxidase subunit 6A1, mitochondrial Cytochrome c oxidase subunit 6B1 Cytochrome c oxidase subunit 6C Cytochrome c oxidase subunit 7A-related protein, mitochondrial Cytochrome c oxidase subunit 7B, mitochondrial Cytochrome c oxidase subunit 7C, mitochondrial Cytochrome c oxidase subunit 8A, mitochondrial Cytochrome c oxidase subunit NDUFA4 Cytochrome c DNA damage-inducible transcript 4 protein Fructose-2,6-bisphosphatase TIGAR GTP-binding protein Rheb Glucose-6-phosphate 1-dehydrogenase Glucose-6-phosphate isomerase Glutaminase kidney isoform, mitochondrial Glutaminase liver isoform, mitochondrial Glutathione peroxidase 2 Hamartin Helicase MOV-10 Leucine-rich PPR motif-containing protein, mitochondrial Neutral amino acid transporter 9 Peroxiredoxin-1 Peroxiredoxin-2 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Protein SCO1 homolog, mitochondrial Protein SCO2 homolog, mitochondrial Protein argonaute-1 Protein argonaute-2 Protein argonaute-3 Protein argonaute-4 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Ribonucleoside-diphosphate reductase subunit M2 B Serine/threonine-protein kinase mTOR Sestrin-2 Sestrin-3 Surfeit locus protein 1 Target of rapamycin complex subunit LST8 Thioredoxin reductase 1, cytoplasmic Thioredoxin Translational activator of cytochrome c oxidase 1 Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein Tuberin Tumor protein 63	O00483 O14548 O43504 O43741 O43819 O75880 O94925 P00395 P00403 P00414 P04637 P06744 P09669 P10176 P10599 P10606 P11413 P12074 P13073 P14854 P15954 P18283 P20674 P24311 P27348 P31749 P31751 P31946 P31947 P32119 P42345 P42704 P49815 P54619 P54646 P58004 P58005 P60484 P61981 P62258 P63104 P99999 Q04917 Q06830 Q0VGL1 Q13131 Q15382 Q15526 Q16881 Q49B96 Q5RI15 Q5VZM2 Q6IAA8 Q7L523 Q7LG56 Q8N122 Q8N8Q8 Q8NBW4 Q8NDV7 Q92574 Q96I36 Q9BSH4 Q9BVC4 Q9H3D4 Q9H9G7 Q9HB90 Q9HCE1 Q9HCJ0 Q9HCK5 Q9NQ88 Q9NQL2 Q9NX09 Q9P0S2 Q9UGI9 Q9UGJ0 Q9UHA4 Q9UI32 Q9UKV8 Q9UL18 Q9UPQ9 Q9Y243 Q9Y2Q5 Q9Y478 Q9Y6N1	AGO1 AGO2 AGO3 AGO4 AKT1 AKT2 AKT3 AMPK AMPK1 AMPK2 AMPKG3 C11orf59 C12orf5 C12orf62 C14orf112 C7orf59 CAGH26 CCDC44 COI COII COIII COX11 COX14 COX16 COX18 COX19 COX2 COX20 COX4 COX4I1 COX5A COX5B COX6A1 COX6AL COX6B COX6B1 COX6C COX7A2L COX7AR COX7B COX7C COX7RP COX8 COX8A COX8L COXI COXII COXIII CYC CYCS DDIT4 EIF2C1 EIF2C2 EIF2C3 EIF2C4 FAM36A FRAP FRAP1 FRAP2 G6PD GA GBL GLS GLS1 GLS2 GPI GPX2 GRIM12 HBXIP HME1 Hi95 KDRF KET KIAA0243 KIAA0838 KIAA1093 KIAA1303 KIAA1460 KIAA1567 KIAA1582 KIAA1631 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LRP130 LRPPRC LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MMAC1 MOV10 MT-CO1 MT-CO2 MT-CO3 MTCO1 MTCO2 MTCO3 MTOR NDUFA4 NKEFB OXA1L2 P53 P53R2 P63 P73H P73L PAGA PAGB PDRO PKB PKBG PRDX1 PRDX2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PTEN RAC RAFT1 RAPT1 RAPTOR REDD1 RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD RRM2B RTP801 SCO1 SCO2 SCOD1 SESN2 SESN3 SEST2 SEST3 SFN SLC38A9 SURF-1 SURF1 TACO1 TDPX1 TDPX2 TEP1 TIGAR TNRC6 TNRC6A TNRC6B TNRC6C TP53 TP63 TP73L TRDX TRX TRX1 TSC TSC1 TSC2 TSC4 TXN TXNRD1 URLC11 XIP YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Translocation of SLC2A4 (GLUT4) to the plasma membrane	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 C2 domain-containing protein 5 Calmodulin-1 Exocyst complex component 1 Exocyst complex component 2 Exocyst complex component 3 Exocyst complex component 4 Exocyst complex component 5 Exocyst complex component 6 Exocyst complex component 7 Exocyst complex component 8 Kinesin-associated protein 3 Kinesin-like protein KIF3A Kinesin-like protein KIF3B Leucyl-cystinyl aminopeptidase Myosin-9 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase Ral GTPase-activating protein subunit alpha-2 Ral GTPase-activating protein subunit beta Ras-related C3 botulinum toxin substrate 1 Ras-related protein Rab-10 Ras-related protein Rab-11A Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-4A Ras-related protein Rab-8A Ras-related protein Ral-A Rho-related GTP-binding protein RhoQ Solute carrier family 2, facilitated glucose transporter member 4 Synaptosomal-associated protein 23 Syntaxin-4 Syntaxin-binding protein 3 TBC1 domain family member 1 TBC1 domain family member 4 Tether containing UBX domain for GLUT4 Unconventional myosin-Ic Unconventional myosin-Va Vesicle-associated membrane protein 2	O00159 O00161 O00186 O00471 O15066 O43741 O60343 O60645 P0DP23 P11233 P14672 P17081 P20338 P27348 P31749 P31751 P31946 P31947 P35579 P51153 P54619 P54646 P61006 P61026 P61106 P61981 P62258 P62491 P63000 P63027 P63104 Q04917 Q12846 Q2PPJ7 Q86TI0 Q86X10 Q86YS7 Q8IYI6 Q8TAG9 Q92845 Q96A65 Q96KP1 Q9BZE9 Q9NV70 Q9UGI9 Q9UGJ0 Q9UIQ6 Q9UPT5 Q9Y478 Q9Y496 Q9Y4I1	AKT1 AKT2 AMPK AMPK2 AMPKG3 ARHQ AS160 ASPL ASPSCR1 C20orf74 C2CD5 CALM CALM1 CAM CAM1 CDP138 EXO70 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 GLUT4 HME1 KIAA0359 KIAA0528 KIAA0603 KIAA1067 KIAA1108 KIAA1219 KIAA1272 KIAA1699 KIF3 KIF3A KIF3AP KIF3B KIFAP3 LNPEP MEL MYH12 MYH9 MYO1C MYO5A OTASE PKB PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RAB10 RAB11 RAB11A RAB13 RAB14 RAB4 RAB4A RAB8 RAB8A RAC RAC1 RAL RALA RALGAPA2 RALGAPB RASL7A RCC17 RHOQ SEC10 SEC10L1 SEC15A SEC15L SEC15L1 SEC3 SEC3L1 SEC5 SEC5L1 SEC6 SEC6L1 SEC8 SEC8L1 SFN SLC2A4 SMAP SNAP23 STX4 STX4A STXBP3 SYB2 TBC1D1 TBC1D4 TC10 TC25 TUG UBXD9 UBXN9 VAMP2 YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Activation of BAD and translocation to mitochondria	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta Apoptosis regulator Bcl-2 BH3-interacting domain death agonist Bcl2-associated agonist of cell death Calcineurin subunit B type 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	P10415 P27348 P31749 P31751 P31946 P31947 P48454 P55957 P61981 P62258 P63098 P63104 Q04917 Q92934 Q9Y243	AKT1 AKT2 AKT3 BAD BBC6 BCL2 BCL2L8 BID CALNA3 CNA2 CNA3 CNB HME1 PKB PKBG PPP3CC PPP3R1 RAC SFN YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 M-phase inducer phosphatase 3 Serine/threonine-protein kinase Chk1 Serine/threonine-protein kinase Chk2 Wee1-like protein kinase	O14757 O96017 P06493 P14635 P27348 P30291 P30307 P31946 P31947 P61981 P62258 P63104 Q04917	CCNB CCNB1 CDC2 CDC25C CDC28A CDK1 CDKN1 CDS1 CHEK1 CHEK2 CHK1 CHK2 HME1 P34CDC2 RAD53 SFN WEE1 YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Signaling by Hippo	14-3-3 protein beta/alpha 14-3-3 protein epsilon Angiomotin-like protein 1 Angiomotin-like protein 2 Caspase-3 MOB kinase activator 1A MOB kinase activator 1B Nephrocystin-4 Protein KIBRA Protein salvador homolog 1 Segment polarity protein dishevelled homolog DVL-2 Serine/threonine-protein kinase 3 Serine/threonine-protein kinase 4 Serine/threonine-protein kinase LATS1 Serine/threonine-protein kinase LATS2 Tight junction protein ZO-1 Tight junction protein ZO-2 Transcriptional coactivator YAP1 WW domain-containing transcription regulator protein 1	O14641 O75161 O95835 P31946 P42574 P46937 P62258 Q07157 Q13043 Q13188 Q7L9L4 Q8IX03 Q8IY63 Q9GZV5 Q9H4B6 Q9H8S9 Q9NRM7 Q9UDY2 Q9Y2J4	AMOTL1 AMOTL2 C2orf6 CASP3 CPP32 DVL2 KIAA0673 KIAA0869 KIAA0989 KIBRA KPM KRS1 KRS2 LATS1 LATS2 MOB1A MOB1B MOB4A MOB4B MOBK1B MOBKL1A MOBKL1B MST1 MST2 NPHP4 SAV1 STK3 STK4 TAZ TJP1 TJP2 WARTS WW45 WWC1 WWTR1 X104 YAP1 YAP65 YWHAB YWHAE ZO1 ZO2
Regulation of localization of FOXO transcription factors	14-3-3 protein beta/alpha 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta Forkhead box protein O1 Forkhead box protein O3 Forkhead box protein O4 Forkhead box protein O6 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase	A8MYZ6 O43524 P27348 P31749 P31751 P31946 P31947 P61981 P63104 P98177 Q12778 Q9Y243	AFX AFX1 AKT1 AKT2 AKT3 FKHR FKHRL1 FOXO1 FOXO1A FOXO3 FOXO3A FOXO4 FOXO6 HME1 MLLT7 PKB PKBG RAC SFN YWHAB YWHAG YWHAQ YWHAZ
Rap1 signalling	14-3-3 protein beta/alpha 14-3-3 protein zeta/delta RAF proto-oncogene serine/threonine-protein kinase RAS guanyl-releasing protein 1 RAS guanyl-releasing protein 2 Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 Rap1 GTPase-activating protein 1 Rap1 GTPase-activating protein 2 Ras-related protein Rap-1A Ras-related protein Rap-1b Signal-induced proliferation-associated protein 1 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	O95267 O95398 P04049 P17612 P22612 P22694 P31946 P47736 P61224 P62834 P63104 Q684P5 Q7LDG7 Q8WZA2 Q96FS4	CDC25L CGEF1 CGEF2 EPAC EPAC1 EPAC2 GARNL4 KIAA0474 KIAA1039 KREV1 MCG7 PKACA PRKACA PRKACB PRKACG RAF RAF1 RAP1A RAP1B RAP1GA1 RAP1GA2 RAP1GAP RAP1GAP2 RAPGEF3 RAPGEF4 RASGRP RASGRP1 RASGRP2 SIPA1 SPA1 YWHAB YWHAZ
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	14-3-3 protein beta/alpha 5'-3' exoribonuclease 1 Exosome complex component CSL4 Exosome complex component MTR3 Exosome complex component RRP40 Exosome complex component RRP41 Exosome complex component RRP42 Exosome complex component RRP43 Exosome complex component RRP45 Exosome complex component RRP46 Exosome complex component RRP4 Exosome complex exonuclease RRP44 MAP kinase-activated protein kinase 2 RAC-alpha serine/threonine-protein kinase m7GpppN-mRNA hydrolase mRNA decay activator protein ZFP36L1 mRNA-decapping enzyme 1A	P31749 P31946 P49137 Q06265 Q07352 Q13868 Q15024 Q5RKV6 Q8IU60 Q8IZH2 Q96B26 Q9NPD3 Q9NPI6 Q9NQT4 Q9NQT5 Q9Y2L1 Q9Y3B2	AKT1 BERG36 BRF1 CML28 CSL4 DCP1A DCP2 DIS3 ERF1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 KIAA0116 KIAA1008 MAPKAPK2 MTR3 NUDT20 OIP2 PKB PMSCL1 RAC RNF162B RRP4 RRP40 RRP41 RRP42 RRP43 RRP44 RRP46 SEP1 SKI6 SMIF TIS11B XRN1 YWHAB ZFP36L1
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	14-3-3 protein beta/alpha 5'-3' exoribonuclease 1 Exosome complex component CSL4 Exosome complex component MTR3 Exosome complex component RRP40 Exosome complex component RRP41 Exosome complex component RRP42 Exosome complex component RRP43 Exosome complex component RRP45 Exosome complex component RRP46 Exosome complex component RRP4 Exosome complex exonuclease RRP44 MAP kinase-activated protein kinase 2 Transportin-1 m7GpppN-mRNA hydrolase mRNA decay activator protein ZFP36 mRNA-decapping enzyme 1A	P26651 P31946 P49137 Q06265 Q13868 Q15024 Q5RKV6 Q8IU60 Q8IZH2 Q92973 Q96B26 Q9NPD3 Q9NPI6 Q9NQT4 Q9NQT5 Q9Y2L1 Q9Y3B2	CML28 CSL4 DCP1A DCP2 DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 G0S24 KIAA0116 KIAA1008 KPNB2 MAPKAPK2 MIP1 MTR3 NUDT20 NUP475 OIP2 PMSCL1 RNF162A RRP4 RRP40 RRP41 RRP42 RRP43 RRP44 RRP46 SEP1 SKI6 SMIF TIS11A TNPO1 TRN TTP XRN1 YWHAB ZFP36
Signaling by BRAF and RAF1 fusions	14-3-3 protein beta/alpha A-kinase anchor protein 9 AP-3 complex subunit beta-1 Acylglycerol kinase, mitochondrial Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Angiogenic factor with G patch and FHA domains 1 Bcl-2-like protein 11 Beta-arrestin-1 Beta-arrestin-2 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Epithelial splicing regulatory protein 1 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas H(+)/Cl(-) exchange transporter 6 Integrin alpha-IIb Integrin beta-3 KH domain-containing RNA-binding protein QKI Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 Lysine-specific demethylase 7A MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Myosin phosphatase Rho-interacting protein Phosphatidylethanolamine-binding protein 1 Prelamin-A/C Protein FAM114A2 Protein FAM131B Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase RNA-binding protein FXR1 Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Staphylococcal nuclease domain-containing protein 1 Talin-1 Terminal nucleotidyltransferase 4A Trafficking kinesin-binding protein 1 Transcription intermediary factor 1-alpha Type-1 angiotensin II receptor-associated protein Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 UPF0606 protein KIAA1549 Ubiquitin-like modifier-activating enzyme ATG7 Vinculin Zinc finger CCCH-type antiviral protein 1 von Willebrand factor	O00203 O15164 O43252 O43521 O60674 O95352 P01111 P01112 P02545 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P36507 P41240 P46940 P49407 P51114 P51797 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q53H12 Q5XG87 Q6NXG1 Q6RW13 Q6VAB6 Q6WCQ1 Q6ZMT4 Q7KZF4 Q7Z2W4 Q7Z5R6 Q86XD5 Q8IVT5 Q8N302 Q8WXI2 Q969H4 Q96PU8 Q99996 Q9HCM3 Q9NRY5 Q9UPV9 Q9UQM7 Q9Y490	ADTB3A AGGF1 AGK AGTRAP AKAP350 AKAP450 AKAP9 AP3B1 APBB1IP APG7L ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 ATG7 ATPSK1 ATRAP BCL2L11 BIM BRAF BRAF1 C5orf3 CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CLCN6 CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 ESRP1 F8VWF FAM114A2 FAM131B FGA FGB FGG FN FN1 FXR1 GP2B GP3A GPATC7 GPATCH7 HKQ HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 JHDM1D KDM7 KDM7A KIAA0046 KIAA0051 KIAA0773 KIAA0803 KIAA0864 KIAA0902 KIAA0968 KIAA1027 KIAA1042 KIAA1549 KIAA1718 KREV1 KSR KSR1 KSR2 LMN1 LMNA MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 MPRIP MRIP MULK NRAS OIP106 PAPD7 PAPSS PAPSS1 PBP PEBP PEBP1 PKS PKS2 POLS PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 QKI RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RBM35A RHOIP3 RIAM RNF82 SND1 SRC SRC1 TDRD11 TENT4A TIF1 TIF1A TLN TLN1 TRAK1 TRF4 TRIM24 VCL VG5Q VWF YWHAB ZC3HAV1 ZC3HDC2
ARMS-mediated activation	14-3-3 protein beta/alpha Adapter molecule crk Beta-nerve growth factor High affinity nerve growth factor receptor Kinase D-interacting substrate of 220 kDa Ras-related protein Rap-1A Serine/threonine-protein kinase B-raf	P01138 P04629 P15056 P31946 P46108 P62834 Q9ULH0	ARMS BRAF BRAF1 CRK KIAA1250 KIDINS220 KREV1 MTC NGF NGFB NTRK1 RAFB1 RAP1A TRK TRKA YWHAB
Signaling downstream of RAS mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein BRCA1-associated protein Beta-arrestin-1 Beta-arrestin-2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase KRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase kinase kinase 11 Phosphatidylethanolamine-binding protein 1 Prohibitin 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 Vinculin von Willebrand factor	O60674 P01111 P01112 P01116 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P35232 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q16584 Q6VAB6 Q7Z569 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9UQM7 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 BRAP CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 KIAA0051 KIAA0902 KIAA0968 KIAA1027 KRAS KRAS2 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 MLK3 NRAS PBP PEBP PEBP1 PHB PHB1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 PTK1 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RASK2 RIAM RNF52 SPRK SRC SRC1 TLN TLN1 VCL VWF YWHAB
Signaling by moderate kinase activity BRAF mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein BRCA1-associated protein Beta-arrestin-1 Beta-arrestin-2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase KRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase kinase kinase 11 Phosphatidylethanolamine-binding protein 1 Prohibitin 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 Vinculin von Willebrand factor	O60674 P01111 P01112 P01116 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P35232 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q16584 Q6VAB6 Q7Z569 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9UQM7 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 BRAP CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 KIAA0051 KIAA0902 KIAA0968 KIAA1027 KRAS KRAS2 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 MLK3 NRAS PBP PEBP PEBP1 PHB PHB1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 PTK1 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RASK2 RIAM RNF52 SPRK SRC SRC1 TLN TLN1 VCL VWF YWHAB
Paradoxical activation of RAF signaling by kinase inactive BRAF	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein BRCA1-associated protein Beta-arrestin-1 Beta-arrestin-2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase KRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase kinase kinase 11 Phosphatidylethanolamine-binding protein 1 Prohibitin 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 Vinculin von Willebrand factor	O60674 P01111 P01112 P01116 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P35232 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q16584 Q6VAB6 Q7Z569 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9UQM7 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 BRAP CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 KIAA0051 KIAA0902 KIAA0968 KIAA1027 KRAS KRAS2 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 MLK3 NRAS PBP PEBP PEBP1 PHB PHB1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 PTK1 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RASK2 RIAM RNF52 SPRK SRC SRC1 TLN TLN1 VCL VWF YWHAB
Signaling by RAF1 mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Beta-arrestin-1 Beta-arrestin-2 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase JAK2 Vinculin von Willebrand factor	O60674 P01111 P01112 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P0DP23 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P31946 P32121 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q13554 Q13555 Q13557 Q6VAB6 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9UQM7 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 JAK2 KIAA0051 KIAA0902 KIAA0968 KIAA1027 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 NRAS PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RIAM SRC SRC1 TLN TLN1 VCL VWF YWHAB
MAP2K and MAPK activation	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Beta-arrestin-1 Beta-arrestin-2 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Interleukin-17 receptor D Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylethanolamine-binding protein 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Vinculin WD repeat domain-containing protein 83 von Willebrand factor	P01111 P01112 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q6VAB6 Q7Z5R6 Q8IVT5 Q8NFM7 Q8WXI2 Q969H4 Q9BRX9 Q9UHA4 Q9Y2Q5 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IL17RD IL17RLM IQGAP1 ITGA2B ITGAB ITGB3 KIAA0051 KIAA0902 KIAA1027 KREV1 KSR KSR1 KSR2 LAMTOR2 LAMTOR3 MAP2K1 MAP2K1IP1 MAP2K2 MAPBPIP MAPK1 MAPK3 MAPKSP1 MARK3 MEK1 MEK2 MKK2 MORG1 NRAS PBP PEBP PEBP1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RIAM ROBLD3 SEF SRC SRC1 TLN TLN1 VCL VWF WDR83 YWHAB
Signaling by high-kinase activity BRAF mutants	14-3-3 protein beta/alpha Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Beta-arrestin-1 Beta-arrestin-2 Connector enhancer of kinase suppressor of ras 1 Connector enhancer of kinase suppressor of ras 2 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin GTPase HRas GTPase NRas Integrin alpha-IIb Integrin beta-3 Kinase suppressor of Ras 1 Kinase suppressor of Ras 2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylethanolamine-binding protein 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras GTPase-activating-like protein IQGAP1 Ras-related protein Rap-1A Ras-related protein Rap-1b Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Talin-1 Tyrosine-protein kinase CSK Vinculin von Willebrand factor	P01111 P01112 P02671 P02675 P02679 P02751 P04049 P04275 P05106 P08514 P10398 P12931 P15056 P18206 P27361 P27448 P28482 P30086 P31946 P32121 P36507 P41240 P46940 P49407 P61224 P62834 Q02750 Q6VAB6 Q7Z5R6 Q8IVT5 Q8WXI2 Q969H4 Q9Y490	APBB1IP ARAF ARAF1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BRAF BRAF1 CNK1 CNK2 CNKSR1 CNKSR2 CSK CTAK1 EMK2 ERK1 ERK2 F8VWF FGA FGB FGG FN FN1 GP2B GP3A HRAS HRAS1 IQGAP1 ITGA2B ITGAB ITGB3 KIAA0051 KIAA0902 KIAA1027 KREV1 KSR KSR1 KSR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 MEK1 MEK2 MKK2 NRAS PBP PEBP PEBP1 PKS PKS2 PREL1 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAF RAF1 RAFB1 RAP1A RAP1B RARP1 RIAM SRC SRC1 TLN TLN1 VCL VWF YWHAB
RAF activation	14-3-3 protein beta/alpha BRCA1-associated protein Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 GTPase HRas GTPase NRas Kinase suppressor of Ras 1 Leucine-rich repeat protein SHOC-2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase kinase kinase 11 Prohibitin 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras-related protein M-Ras Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Tyrosine-protein kinase JAK2	O14807 O60674 P01111 P01112 P04049 P0DP23 P10398 P12931 P15056 P27448 P30153 P30154 P31946 P35232 P36507 P36873 P62140 P62714 P67775 Q02750 Q13362 Q13554 Q13555 Q13557 Q14738 Q15172 Q15173 Q16537 Q16584 Q7Z569 Q8IVT5 Q9UQ13 Q9UQM7	ARAF ARAF1 BRAF BRAF1 BRAP CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CTAK1 EMK2 HRAS HRAS1 JAK2 KIAA0044 KIAA0862 KIAA0968 KSR KSR1 MAP2K1 MAP2K2 MAP3K11 MARK3 MEK1 MEK2 MKK2 MLK3 MRAS NRAS PHB PHB1 PKS PKS2 PPP1CB PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKMK1 PRKMK2 PTK1 RAF RAF1 RAFB1 RNF52 RRAS3 SHOC2 SPRK SRC SRC1 YWHAB
Negative regulation of MAPK pathway	14-3-3 protein beta/alpha BRCA1-associated protein Dual specificity protein phosphatase 10 Dual specificity protein phosphatase 16 Dual specificity protein phosphatase 1 Dual specificity protein phosphatase 2 Dual specificity protein phosphatase 4 Dual specificity protein phosphatase 5 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Dual specificity protein phosphatase 8 Dual specificity protein phosphatase 9 GTPase HRas GTPase NRas Kinase suppressor of Ras 1 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylethanolamine-binding protein 1 Polyubiquitin-B Polyubiquitin-C Progestin and adipoQ receptor family member 3 RAF proto-oncogene serine/threonine-protein kinase Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase 5 Tyrosine-protein phosphatase non-receptor type 3 Tyrosine-protein phosphatase non-receptor type 7 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P01111 P01112 P04049 P0CG47 P0CG48 P10398 P15056 P26045 P27361 P27448 P28482 P28562 P30086 P30153 P30154 P31946 P35236 P53041 P53778 P62714 P62979 P62987 P67775 Q05923 Q13115 Q13202 Q13362 Q14738 Q15172 Q15173 Q16537 Q16690 Q16828 Q16829 Q6TCH7 Q7Z569 Q8IVT5 Q99956 Q9BY84 Q9Y6W6	ARAF ARAF1 BRAF BRAF1 BRAP C11orf81 CL100 CTAK1 DUSP1 DUSP10 DUSP16 DUSP2 DUSP4 DUSP5 DUSP6 DUSP7 DUSP8 DUSP9 EMK2 ERK1 ERK2 ERK6 HRAS HRAS1 KIAA0044 KIAA1700 KSR KSR1 MAPK1 MAPK12 MAPK3 MARK3 MKP1 MKP2 MKP3 MKP4 MKP5 MKP7 NRAS PAC1 PAQR3 PBP PEBP PEBP1 PKS PKS2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPP5 PPP5C PRKM1 PRKM2 PRKM3 PTPH1 PTPN10 PTPN3 PTPN7 PYST1 PYST2 RAF RAF1 RAFB1 RNF52 RPS27A SAPK3 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VH1 VH2 VH3 VH5 YWHAB
Frs2-mediated activation	14-3-3 protein beta/alpha Beta-nerve growth factor Crk-like protein Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibroblast growth factor receptor substrate 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Rap guanine nucleotide exchange factor 1 Ras-related protein Rap-1A Serine/threonine-protein kinase B-raf	P01138 P15056 P27361 P28482 P31946 P36507 P46109 P62834 Q02750 Q13905 Q8WU20	BRAF BRAF1 CRKL ERK1 ERK2 FRS2 GRF2 KREV1 MAP2K1 MAP2K2 MAPK1 MAPK3 MEK1 MEK2 MKK2 NGF NGFB PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAFB1 RAP1A RAPGEF1 YWHAB
mTORC1-mediated signalling	14-3-3 protein beta/alpha Eukaryotic elongation factor 2 kinase Eukaryotic translation initiation factor 4 gamma 1 Eukaryotic translation initiation factor 4B Eukaryotic translation initiation factor 4E-binding protein 1 Eukaryotic translation initiation factor 4E GTP-binding protein Rheb Neutral amino acid transporter 9 Peptidyl-prolyl cis-trans isomerase FKBP1A Proline-rich AKT1 substrate 1 Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Ribosomal protein S6 kinase beta-1 Serine/threonine-protein kinase mTOR Small ribosomal subunit protein eS6 Target of rapamycin complex subunit LST8	O00418 O43504 P06730 P23443 P23588 P31946 P42345 P62753 P62942 Q04637 Q0VGL1 Q13541 Q15382 Q5VZM2 Q6IAA8 Q7L523 Q8N122 Q8NBW4 Q96B36 Q9BVC4 Q9HB90 Q9NQL2 Q9UHA4 Q9Y2Q5	AKT1S1 C11orf59 C7orf59 EEF2K EIF4B EIF4E EIF4EBP1 EIF4EL1 EIF4F EIF4G EIF4G1 EIF4GI FKBP1 FKBP12 FKBP1A FRAP FRAP1 FRAP2 GBL HBXIP KIAA1303 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MTOR PDRO PRAS40 RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPS6 RPS6KB1 RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 STK14A URLC11 XIP YWHAB
MTOR signalling	14-3-3 protein beta/alpha GTP-binding protein Rheb Neutral amino acid transporter 9 Proline-rich AKT1 substrate 1 RAC-alpha serine/threonine-protein kinase Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein A Ras-related GTP-binding protein B Ras-related GTP-binding protein C Ras-related GTP-binding protein D Regulatory-associated protein of mTOR Serine/threonine-protein kinase mTOR Target of rapamycin complex subunit LST8	O43504 P31749 P31946 P42345 Q0VGL1 Q15382 Q5VZM2 Q6IAA8 Q7L523 Q8N122 Q8NBW4 Q96B36 Q9BVC4 Q9HB90 Q9NQL2 Q9UHA4 Q9Y2Q5	AKT1 AKT1S1 C11orf59 C7orf59 FRAP FRAP1 FRAP2 GBL HBXIP KIAA1303 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LST8 MAP2K1IP1 MAPBPIP MAPKSP1 MLST8 MTOR PDRO PKB PRAS40 RAC RAFT1 RAPT1 RAPTOR RHEB RHEB2 ROBLD3 RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 URLC11 XIP YWHAB
SHOC2 M1731 mutant abolishes MRAS complex function	14-3-3 protein beta/alpha Leucine-rich repeat protein SHOC-2 RAF proto-oncogene serine/threonine-protein kinase Ras-related protein M-Ras Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	O14807 P04049 P10398 P15056 P31946 P36873 P62140 Q9UQ13	ARAF ARAF1 BRAF BRAF1 KIAA0862 MRAS PKS PKS2 PPP1CB PPP1CC RAF RAF1 RAFB1 RRAS3 SHOC2 YWHAB
Gain-of-function MRAS complexes activate RAF signaling	14-3-3 protein beta/alpha Leucine-rich repeat protein SHOC-2 RAF proto-oncogene serine/threonine-protein kinase Ras-related protein M-Ras Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	O14807 P04049 P10398 P15056 P31946 P36873 P62140 Q9UQ13	ARAF ARAF1 BRAF BRAF1 KIAA0862 MRAS PKS PKS2 PPP1CB PPP1CC RAF RAF1 RAFB1 RRAS3 SHOC2 YWHAB
Regulation of PLK1 Activity at G2/M Transition	14-3-3 protein epsilon 14-3-3 protein gamma A-kinase anchor protein 9 Alpha-centractin Aurora kinase A CDK5 regulatory subunit-associated protein 2 CLIP-associating protein 1 Casein kinase I isoform delta Casein kinase I isoform epsilon Centrin-2 Centriolar coiled-coil protein of 110 kDa Centriole and centriolar satellite protein OFD1 Centriolin Centromere protein J Centrosomal protein 43 Centrosomal protein of 131 kDa Centrosomal protein of 135 kDa Centrosomal protein of 152 kDa Centrosomal protein of 164 kDa Centrosomal protein of 192 kDa Centrosomal protein of 290 kDa Centrosomal protein of 41 kDa Centrosomal protein of 57 kDa Centrosomal protein of 63 kDa Centrosomal protein of 70 kDa Centrosomal protein of 72 kDa Centrosomal protein of 76 kDa Centrosomal protein of 78 kDa Centrosome-associated protein ALMS1 Centrosome-associated protein CEP250 Cullin-1 Cyclin-dependent kinase 1 Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoskeleton-associated protein 5 Dynactin subunit 2 Dynactin subunit 3 Dynein light chain 1, cytoplasmic F-box/WD repeat-containing protein 11 F-box/WD repeat-containing protein 1A G2/mitotic-specific cyclin-B1 G2/mitotic-specific cyclin-B2 HAUS augmin-like complex subunit 1 HAUS augmin-like complex subunit 2 HAUS augmin-like complex subunit 3 HAUS augmin-like complex subunit 4 HAUS augmin-like complex subunit 5 HAUS augmin-like complex subunit 6 HAUS augmin-like complex subunit 7 HAUS augmin-like complex subunit 8 Heat shock protein HSP 90-alpha LIM domain-containing protein ajuba Microtubule nucleation factor SSNA1 Microtubule-associated protein RP/EB family member 1 Ninein-like protein Nuclear distribution protein nudE homolog 1 Optineurin Outer dense fiber protein 2 Pericentrin Pericentriolar material 1 protein Platelet-activating factor acetylhydrolase IB subunit beta Polyubiquitin-B Polyubiquitin-C Protein NEDD1 Protein SFI1 homolog Protein aurora borealis Protein phosphatase 1 regulatory subunit 12A Ras-related protein Rab-8A S-phase kinase-associated protein 1 Serine/threonine-protein kinase Nek2 Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase PLK4 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serologically defined colon cancer antigen 8 Tubulin alpha-1A chain Tubulin alpha-4A chain Tubulin beta chain Tubulin beta-4A chain Tubulin beta-4B chain Tubulin gamma-1 chain Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type II-beta regulatory subunit	A8K8P3 O00444 O14965 O14974 O15078 O43303 O43805 O75665 O75935 O94927 O94986 O95067 O95613 O95684 P04350 P06493 P07437 P07900 P0CG47 P0CG48 P14635 P17612 P23258 P30153 P31323 P41208 P43034 P48730 P49674 P51955 P53350 P61006 P61163 P61981 P62140 P62258 P62979 P62987 P63167 P63208 P68366 P68371 Q13409 Q13561 Q13616 Q14008 Q14204 Q15154 Q15691 Q5BJF6 Q5JTW2 Q66GS9 Q68CZ6 Q6PGQ7 Q71U36 Q7Z460 Q7Z4H7 Q7Z7A1 Q86SQ7 Q86XR8 Q8NHQ1 Q8NHV4 Q8TAP6 Q8TCU4 Q8TEP8 Q96CS2 Q96CV9 Q96IF1 Q96MT8 Q96SN8 Q99871 Q99996 Q9BT25 Q9BV73 Q9BYV8 Q9H6D7 Q9HC77 Q9NVX0 Q9NXR1 Q9P209 Q9UKB1 Q9UPN4 Q9UPV0 Q9Y297 Q9Y2I6	ACTR1A AIK AIRK1 AJUBA AKAP350 AKAP450 AKAP9 ALMS1 ARK1 AURA AURKA AYK1 AZI1 BBS14 BITE BORA BTAK BTRC BTRCP BTRCP2 C13orf34 C14orf94 C15orf25 C18orf9 C4orf15 C9orf81 CALT CCCAP CCDC5 CCNB CCNB1 CCNB2 CCP110 CDC2 CDC28A CDK1 CDK5RAP2 CDKN1 CEN2 CENPJ CEP1 CEP110 CEP131 CEP135 CEP152 CEP164 CEP192 CEP2 CEP215 CEP250 CEP27 CEP290 CEP4 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNAP1 CNTRL CP110 CPAP CSNK1D CSNK1E CTRN1 CUL1 CXorf5 DCTN2 DCTN22 DCTN3 DCTN50 DGT6 DHC1 DLC1 DNCH1 DNCI2 DNCIC2 DNCL DNCL1 DNCLC1 DNECL DYHC DYNC1H1 DYNC1I2 DYNLL1 EMC19 FAM29A FBW1A FBW1B FBXW11 FBXW1A FBXW1B FGFR1OP FIP2 FOP GLC1E HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HCKID HDLC1 HEIC HICE1 HIP7 HSP90A HSP90AA1 HSPC1 HSPCA HYPL IAK1 JUB KIAA0092 KIAA0097 KIAA0325 KIAA0328 KIAA0373 KIAA0402 KIAA0419 KIAA0542 KIAA0622 KIAA0635 KIAA0696 KIAA0803 KIAA0841 KIAA0912 KIAA0980 KIAA1052 KIAA1118 KIAA1519 KIAA1569 KIAA1574 KIAA1633 LAP LIP1 LIS1 MAPRE1 MAST1 MBS MDCR MDS MEL MYPT1 NA14 NDE1 NEDD1 NEK2 NEK2A NINL NLK1 NLP NPHP10 NPHP15 NPHP6 NRP NUDE OCP2 ODF2 OFD1 OPTN P34CDC2 PAFAH1B1 PAFAHA PCM1 PCNT PCNT2 PKACA PLK PLK1 PLK4 PPP1CB PPP1R12A PPP2R1A PRKACA PRKAR2B RAB8 RAB8A RPS27A SAK SDCCAG8 SFI1 SKP1 SKP1A SSNA1 STK15 STK18 STK6 TCEB1L TSGA14 TSP57 TUBA1 TUBA1A TUBA3 TUBA4A TUBB TUBB2C TUBB4 TUBB4A TUBB4B TUBB5 TUBG TUBG1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UCHL5IP UIP1 YWHAE YWHAG

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