GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **1451 - 1475** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism ▲
Synthesis of PC	Acetylcholinesterase Casein kinase II subunit alpha' Casein kinase II subunit alpha Casein kinase II subunit beta Choline O-acetyltransferase Choline kinase alpha Choline transporter-like protein 1 Choline transporter-like protein 2 Choline transporter-like protein 3 Choline transporter-like protein 4 Choline transporter-like protein 5 Choline-phosphate cytidylyltransferase A Choline-phosphate cytidylyltransferase B Choline/ethanolamine kinase Choline/ethanolaminephosphotransferase 1 Cholinephosphotransferase 1 Cholinesterase Lysophosphatidylcholine acyltransferase 1 Phosphatidate phosphatase LPIN1 Phosphatidate phosphatase LPIN2 Phosphatidate phosphatase LPIN3 Phosphatidylcholine transfer protein Phosphatidylethanolamine N-methyltransferase Phosphoethanolamine/phosphocholine phosphatase Phospholipase ABHD3 START domain-containing protein 10 Sodium-dependent lysophosphatidylcholine symporter 1 StAR-related lipid transfer protein 7, mitochondrial	P06276 P19784 P22303 P28329 P35790 P49585 P67870 P68400 Q14693 Q53GD3 Q8IWA5 Q8N4M1 Q8NA29 Q8NCS7 Q8NF37 Q8TCT1 Q8WU67 Q8WUD6 Q8WWI5 Q92539 Q9BQK8 Q9NQZ5 Q9UBM1 Q9UKL6 Q9Y259 Q9Y365 Q9Y5K3 Q9Y6K0	ABHD3 ACHE AYTL2 BCHE C6orf29 CCTB CD92 CDW92 CEPT1 CHAT CHE1 CHETK CHK CHKA CHKB CHKL CHPT1 CK2A1 CK2A2 CK2N CKI CPT1 CSNK2A1 CSNK2A2 CSNK2B CTL1 CTL2 CTL3 CTL4 CTL5 CTPCT G5A GTT1 KIAA0188 KIAA0249 LIPN3L LPCAT1 LPIN1 LPIN2 LPIN3 MFSD2 MFSD2A NG22 NLS1 PCTP PCYT1 PCYT1A PCYT1B PEMPT PEMT PFAAP3 PHOSPHO1 PNMT SDCCAG28 SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5 STARD10 STARD2 STARD7 TPPT1	Homo sapiens (human)
Thromboxane signalling through TP receptor	Angio-associated migratory cell protein Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(q) subunit alpha Guanine nucleotide-binding protein subunit alpha-11 Guanine nucleotide-binding protein subunit alpha-13 Guanine nucleotide-binding protein subunit alpha-14 Guanine nucleotide-binding protein subunit alpha-15 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Thromboxane A2 receptor	O14610 O14775 O60262 O95837 P16520 P21731 P29992 P30679 P50148 P50150 P50151 P59768 P61952 P62873 P62879 P63211 P63215 P63218 Q13685 Q14344 Q9HAV0 Q9P2W3 Q9UBI6 Q9UK08	AAMP GA11 GAQ GNA11 GNA13 GNA14 GNA15 GNA16 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 TBXA2R	Homo sapiens (human)
Glucuronidation	Palmitoyl-protein thioesterase ABHD10, mitochondrial UDP-glucuronosyltransferase 1-6 UDP-glucuronosyltransferase 1A10 UDP-glucuronosyltransferase 1A1 UDP-glucuronosyltransferase 1A3 UDP-glucuronosyltransferase 1A4 UDP-glucuronosyltransferase 1A5 UDP-glucuronosyltransferase 1A7 UDP-glucuronosyltransferase 1A8 UDP-glucuronosyltransferase 1A9 UDP-glucuronosyltransferase 2A1 UDP-glucuronosyltransferase 2A2 UDP-glucuronosyltransferase 2A3 UDP-glucuronosyltransferase 2B10 UDP-glucuronosyltransferase 2B11 UDP-glucuronosyltransferase 2B15 UDP-glucuronosyltransferase 2B17 UDP-glucuronosyltransferase 2B28 UDP-glucuronosyltransferase 2B4 UDP-glucuronosyltransferase 2B7 UDP-glucuronosyltransferase 3A1 UDP-glucuronosyltransferase 3A2	O60656 O75310 O75795 P06133 P0DTE4 P0DTE5 P16662 P19224 P22309 P22310 P35503 P35504 P36537 P54855 Q3SY77 Q6NUS8 Q6UWM9 Q9BY64 Q9HAW7 Q9HAW8 Q9HAW9 Q9NUJ1	ABHD10 GNT1 UGT1 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A2 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UGT2B8 UGT3A1 UGT3A2 UGTB2B9	Homo sapiens (human)
SMAD2/3 MH2 Domain Mutants in Cancer	Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4	P84022 Q13485 Q15796	DPC4 MADH2 MADH3 MADH4 MADR2 SMAD2 SMAD3 SMAD4	Homo sapiens (human)
Regulation of MITF-M dependent genes involved in metabolism	NAD-dependent protein deacetylase sirtuin-1 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	Q96EB6 Q9UBK2	LEM6 PGC1 PGC1A PPARGC1 PPARGC1A SIR2L1 SIRT1	Homo sapiens (human)
Activated NTRK3 signals through RAS	GTPase HRas GTPase NRas NT-3 growth factor receptor Neurotrophin-3 Son of sevenless homolog 1	P01111 P01112 P20783 Q07889 Q16288	HRAS HRAS1 NRAS NTF3 NTRK3 SOS1 TRKC	Homo sapiens (human)
Interleukin-36 pathway	Interleukin-1 family member 10 Interleukin-1 receptor-like 2 Interleukin-36 alpha Interleukin-36 beta Interleukin-36 gamma Interleukin-36 receptor antagonist protein	Q8WWZ1 Q9HB29 Q9NZH7 Q9NZH8 Q9UBH0 Q9UHA7	FIL1D FIL1E FIL1T IL1E IL1F10 IL1F5 IL1F6 IL1F8 IL1F9 IL1H1 IL1H2 IL1HY1 IL1HY2 IL1L1 IL1RL2 IL1RP2 IL1RP3 IL1RRP2 IL36A IL36B IL36G IL36RN IL38	Homo sapiens (human)
CD163 mediating an anti-inflammatory response	Disintegrin and metalloproteinase domain-containing protein 17 Furin Inactive rhomboid protein 2 Interleukin-10 Interleukin-6 Mitogen-activated protein kinase 14 Myosin-9 Scavenger receptor cysteine-rich type 1 protein M130 Serine/threonine-protein kinase PLK2	P05231 P09958 P22301 P35579 P78536 Q16539 Q6PJF5 Q86VB7 Q9NYY3	ADAM17 CD163 CSBP CSBP1 CSBP2 CSPB1 CSVP FUR FURIN IFNB2 IL10 IL6 IRHOM2 M130 MAPK14 MXI2 MYH9 PACE PCSK3 PLK2 RHBDF2 RHBDL5 RHBDL6 SAPK2A SNK TACE	Homo sapiens (human)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	14-3-3 protein beta/alpha 5'-3' exoribonuclease 1 Exosome complex component CSL4 Exosome complex component MTR3 Exosome complex component RRP40 Exosome complex component RRP41 Exosome complex component RRP42 Exosome complex component RRP43 Exosome complex component RRP45 Exosome complex component RRP46 Exosome complex component RRP4 Exosome complex exonuclease RRP44 MAP kinase-activated protein kinase 2 RAC-alpha serine/threonine-protein kinase m7GpppN-mRNA hydrolase mRNA decay activator protein ZFP36L1 mRNA-decapping enzyme 1A	P31749 P31946 P49137 Q06265 Q07352 Q13868 Q15024 Q5RKV6 Q8IU60 Q8IZH2 Q96B26 Q9NPD3 Q9NPI6 Q9NQT4 Q9NQT5 Q9Y2L1 Q9Y3B2	AKT1 BERG36 BRF1 CML28 CSL4 DCP1A DCP2 DIS3 ERF1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 KIAA0116 KIAA1008 MAPKAPK2 MTR3 NUDT20 OIP2 PKB PMSCL1 RAC RNF162B RRP4 RRP40 RRP41 RRP42 RRP43 RRP44 RRP46 SEP1 SKI6 SMIF TIS11B XRN1 YWHAB ZFP36L1	Homo sapiens (human)
Respiratory syncytial virus genome transcription	Heat shock cognate 71 kDa protein Nucleoprotein Phosphoprotein Protein M2-1 Protein M2-2 RNA-directed RNA polymerase L	P03418 P03421 P04545 P11142 P28887 P88812	HSC70 HSP73 HSPA10 HSPA8 L M2-1 M2-2 N P	Homo sapiens (human)
Metalloprotease DUBs	26S proteasome non-ATPase regulatory subunit 14 AMSH-like protease BRCA1-A complex subunit Abraxas 1 BRCA1-A complex subunit RAP80 BRCA1-associated RING domain protein 1 BRISC and BRCA1-A complex member 1 BRISC and BRCA1-A complex member 2 BRISC complex subunit Abraxas 2 Breast cancer type 1 susceptibility protein Deubiquitinase MYSM1 Histone H2A type 1-A Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-H Histone H2A type 1-J Histone H2A type 1 Histone H2A type 2-A Histone H2A type 2-B Histone H2A type 2-C Histone H2A type 3 Histone acetyltransferase KAT2B Histone acetyltransferase p300 Lys-63-specific deubiquitinase BRCC36 NACHT, LRR and PYD domains-containing protein 3 Polyubiquitin-B Polyubiquitin-C STAM-binding protein Signal transducing adapter molecule 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00487 O95630 P04908 P0C0S8 P0CG47 P0CG48 P20671 P38398 P46736 P62979 P62987 Q09472 Q15018 Q16777 Q5VVJ2 Q6FI13 Q6UWZ7 Q7L7L0 Q8IUE6 Q92783 Q92831 Q93077 Q96FJ0 Q96KK5 Q96P20 Q96QV6 Q96RL1 Q99728 Q99878 Q9NWV8 Q9NXR7	ABRA1 ABRAXAS1 ABRAXAS2 ABRO1 AMSH AMSHLP BABAM1 BABAM2 BARD1 BRCA1 BRCC3 BRCC36 BRCC45 BRE C19orf62 C1orf7 C6.1A CCDC98 CIAS1 CXorf53 EP300 FAM175A FAM175B H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFC H2AFD H2AFE H2AFG H2AFI H2AFL H2AFM H2AFN H2AFO H2AFP H2AFQ H2AFR H2AW HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AG HIST1H2AH HIST1H2AI HIST1H2AJ HIST1H2AK HIST1H2AL HIST1H2AM HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AB HIST2H2AC HIST3H2A KAT2B KIAA0157 KIAA1373 KIAA1915 MERIT40 MYSM1 NALP3 NBA1 NLRP3 P300 PCAF POH1 PSMD14 PYPAF1 RAP80 RNF53 RPS27A RXRIP110 STAM STAM1 STAMBP STAMBPL1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UIMC1	Homo sapiens (human)
VLDLR internalisation and degradation	AP-2 complex subunit alpha-1 AP-2 complex subunit alpha-2 AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma Clathrin heavy chain 1 Clathrin light chain A E3 ubiquitin-protein ligase MYLIP Oxysterols receptor LXR-alpha Oxysterols receptor LXR-beta Polyubiquitin-B Polyubiquitin-C Proprotein convertase subtilisin/kexin type 9 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Very low-density lipoprotein receptor	O94973 O95782 P09496 P0CG47 P0CG48 P53680 P55055 P62979 P62987 P63010 P98155 Q00610 Q13133 Q8NBP7 Q8WY64 Q96CW1	ADTAA ADTAB ADTB2 AP17 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 BZF1 CLAPA1 CLAPA2 CLAPB1 CLAPM1 CLAPS2 CLH17 CLTA CLTC CLTCL2 HIP9 HYPJ IDOL KIAA0034 KIAA0109 KIAA0899 LXRA LXRB MYLIP NARC1 NER NR1H2 NR1H3 PCSK9 RPS27A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UNR VLDLR	Homo sapiens (human)
RHO GTPases Activate Formins	Actin, cytoplasmic 1 Actin, cytoplasmic 2 Aurora kinase B B9 domain-containing protein 2 Baculoviral IAP repeat-containing protein 5 Borealin CAP-Gly domain-containing linker protein 1 CLIP-associating protein 1 CLIP-associating protein 2 Cell division control protein 42 homolog Cell division cycle protein 20 homolog Centromere protein C Centromere protein F Centromere protein H Centromere protein I Centromere protein K Centromere protein L Centromere protein M Centromere protein N Centromere protein O Centromere protein P Centromere protein Q Centromere protein R Centromere protein S Centromere protein T Centromere protein U Centromere-associated protein E Centromere/kinetochore protein zw10 homolog Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoplasmic dynein 1 light intermediate chain 1 Cytoplasmic dynein 1 light intermediate chain 2 Cytoskeleton-associated protein 5 DNA excision repair protein ERCC-6-like Disheveled-associated activator of morphogenesis 1 Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic E3 SUMO-protein ligase RanBP2 Ena/VASP-like protein Exportin-1 Formin-like protein 1 Formin-like protein 2 Formin-like protein 3 Histone H3-like centromeric protein A Inner centromere protein Integrin beta-1 Kinesin-like protein KIF18A Kinesin-like protein KIF2A Kinesin-like protein KIF2B Kinesin-like protein KIF2C Kinetochore protein NDC80 homolog Kinetochore protein Nuf2 Kinetochore protein Spc24 Kinetochore protein Spc25 Kinetochore scaffold 1 Kinetochore-associated protein 1 Kinetochore-associated protein DSN1 homolog Kinetochore-associated protein NSL1 homolog Microtubule-associated protein RP/EB family member 1 Mitotic checkpoint protein BUB3 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Mitotic checkpoint serine/threonine-protein kinase BUB1 Mitotic spindle assembly checkpoint protein MAD1 Mitotic spindle assembly checkpoint protein MAD2A Myocardin-related transcription factor A Nuclear distribution protein nudE homolog 1 Nuclear distribution protein nudE-like 1 Nuclear migration protein nudC Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup133 Nuclear pore complex protein Nup160 Nuclear pore complex protein Nup85 Nucleoporin Nup37 Nucleoporin Nup43 Platelet-activating factor acetylhydrolase IB subunit beta Polyamine-modulated factor 1 Profilin-1 Profilin-2 Protein ELYS Protein MIS12 homolog Protein RCC2 Protein SCAI Protein SEC13 homolog Protein Spindly Protein diaphanous homolog 1 Protein diaphanous homolog 3 Protein zwilch homolog Ran GTPase-activating protein 1 Ras-related C3 botulinum toxin substrate 1 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoC Rho-related GTP-binding protein RhoD SKA complex subunit 1 SLIT-ROBO Rho GTPase-activating protein 2 Segment polarity protein dishevelled homolog DVL-1 Segment polarity protein dishevelled homolog DVL-2 Segment polarity protein dishevelled homolog DVL-3 Serine/threonine-protein kinase PLK1 Serine/threonine-protein kinase TAO1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Serum response factor Shugoshin 1 Shugoshin 2 Small ribosomal subunit protein eS27 Spindle and kinetochore-associated protein 2 Transforming protein RhoA ZW10 interactor	O00139 O00212 O14576 O14640 O14641 O14777 O14980 O15392 O43237 O43264 O43683 O43684 O60566 O60610 O75044 O75122 O95229 O95466 P05556 P07737 P08134 P11831 P30153 P30154 P30622 P35080 P36873 P42677 P43034 P46060 P49450 P49454 P49792 P50748 P53350 P55735 P57740 P60709 P60953 P61586 P62714 P62745 P63000 P63167 P63261 P67775 Q02224 Q03188 Q12769 Q12834 Q13257 Q13352 Q13362 Q13409 Q14008 Q14204 Q14738 Q15172 Q15173 Q15691 Q16537 Q2NKX8 Q53HL2 Q562F6 Q5FBB7 Q6IPU0 Q6P1K2 Q71F23 Q7L2Z9 Q7L7X3 Q7Z460 Q8IVF7 Q8N0S6 Q8N2Z9 Q8N4N8 Q8N9R8 Q8NBT2 Q8NFH3 Q8NFH4 Q8NG31 Q8NI77 Q8WUM0 Q8WVK7 Q8WYP5 Q92674 Q92997 Q969V6 Q96BD8 Q96BT3 Q96EA4 Q96FJ2 Q96GD4 Q96H22 Q96IY1 Q96PY5 Q99661 Q9BPU9 Q9BS16 Q9BU64 Q9BW27 Q9BZD4 Q9GZM8 Q9H081 Q9H3R5 Q9H410 Q9H900 Q9HBM1 Q9NQS7 Q9NSP4 Q9NSV4 Q9NXR1 Q9P258 Q9UI08 Q9Y266 Q9Y4D1 Q9Y6D9 Q9Y6G9	ACTB ACTG ACTG1 AHCTF1 AIK2 AIM1 AIRK2 API4 APITD1 ARH12 ARH6 ARH9 ARHA ARHB ARHC ARHD ARHGAP34 ARK2 AURKB B9D2 BIRC5 BUB1 BUB1B BUB1L BUB3 BUBR1 C16orf56 C16orf60 C17orf1 C17orf1B C18orf24 C1orf155 C1orf48 C20orf172 C22orf18 C6orf139 C9orf126 CASC5 CCDC99 CDC20 CDC42 CDCA1 CDCA8 CENPA CENPC CENPC1 CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPR CENPS CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 CRM1 CYLN1 D3S1231E DAAM1 DHC1 DIAP1 DIAP3 DIAPH1 DIAPH3 DLC1 DLC2 DNCH1 DNCI1 DNCI2 DNCIC1 DNCIC2 DNCL DNCL1 DNCLC1 DNCLI1 DNCLI2 DNECL DSN1 DVL1 DVL2 DVL3 DYHC DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ELYS EOPA ERCC6L EVL FAAP16 FAM33A FHOD2 FHOD3 FMNL FMNL1 FMNL2 FMNL3 FNBP2 FNRB FRL1 FRL2 FSHPRH1 HDLC1 HEC HEC1 IAP4 ICEN19 ICEN22 ICEN24 ICEN32 ICEN33 ICEN35 ICEN36 ICEN37 ICEN39 ICEN7 INCENP ITGB1 ITGB3BP KIAA0044 KIAA0097 KIAA0166 KIAA0197 KIAA0208 KIAA0325 KIAA0456 KIAA0622 KIAA0627 KIAA0666 KIAA1361 KIAA1438 KIAA1470 KIAA1570 KIAA1835 KIAA1902 KIAA2014 KIF18A KIF2 KIF2A KIF2B KIF2C KLIP1 KNL1 KNS2 KNSL6 KNTC1 KNTC2 LIC2 LIS1 LRPR1 MAD1 MAD1L1 MAD2 MAD2L1 MAD3L MAL MAP3K16 MAPRE1 MARKK MAST1 MCM21R MDCR MDF2 MDS MHF1 MIS12 MIS13 MITAP1 MKL1 MKSR2 MLF1IP MPS1 MRTFA MSK12 NDC80 NDE1 NDEL1 NRIF3 NSL1 NUDC NUDE NUDEL NUF2 NUF2R NUP107 NUP120 NUP133 NUP160 NUP358 NUP37 NUP43 NUP75 NUP85 PAFAH1B1 PAFAHA PANE1 PBIP1 PCNT1 PESCRG3 PFN1 PFN2 PICH PLK PLK1 PMF1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RAC1 RANBP2 RANGAP1 RCC2 RHO12 RHOA RHOB RHOC RHOD RNB6 ROD RPS27 RSN SCAI SD SEC13 SEC13A SEC13L1 SEC13R SGO1 SGO2 SGOL1 SGOL2 SKA1 SKA2 SPBC24 SPBC25 SPC24 SPC25 SPDL1 SRF SRGAP2 SRGAP2A SSK1 STK1 STK12 STK5 TAOK1 TC25 TD60 TMBS62 TXBP181 WBP3 XPO1 ZW10 ZWILCH ZWINT	Homo sapiens (human)
Proteasome assembly	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Proteasomal ATPase-associated factor 1 Proteasomal ubiquitin receptor ADRM1 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome assembly chaperone 1 Proteasome assembly chaperone 2 Proteasome assembly chaperone 3 Proteasome assembly chaperone 4 Proteasome inhibitor PI31 subunit Proteasome maturation protein Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9	A5LHX3 O00231 O00232 O00233 O00487 O14818 O43242 O75832 O95456 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 Q06323 Q13200 Q14997 Q15008 Q16186 Q16401 Q5JS54 Q8TAA3 Q92530 Q969U7 Q99436 Q99460 Q9BRP4 Q9BT73 Q9UL46 Q9UNM6 Q9Y244	ADRM1 BLM10 C13orf12 C21LRP C6orf86 C7orf48 C7orf76 DSCR2 DSS1 GP110 HC2 HC3 HC8 HC9 HCCA3 HSPC IFI5111 KIAA0072 KIAA0077 KIAA0107 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NU PAAF1 PAC1 PAC2 PAC3 PAC4 PFAAP4 POH1 POMP PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PSMG1 PSMG2 PSMG3 PSMG4 RING10 RING12 SEM1 SHFDG1 SHFM1 SUG1 SUG2 TBP1 TBP7 TNFSF5IP1 TRAP2 UMP1 WDR71 X Y Y2 Z	Homo sapiens (human)
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 Cyclin-dependent kinase 6 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase inhibitor 1C G1/S-specific cyclin-D1 G1/S-specific cyclin-D2 G1/S-specific cyclin-D3 G1/S-specific cyclin-E1 G1/S-specific cyclin-E2 Retinoblastoma-associated protein Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F2 Transcription factor E2F3	O00716 O96020 P06400 P11802 P24385 P24864 P24941 P30279 P30281 P38936 P46527 P49918 Q00534 Q01094 Q14186 Q14188 Q14209	BCL1 CAP20 CCND1 CCND2 CCND3 CCNE CCNE1 CCNE2 CDK2 CDK4 CDK6 CDKN1 CDKN1A CDKN1B CDKN1C CDKN2 CDKN6 CIP1 DP1 DP2 E2F1 E2F2 E2F3 KIAA0075 KIP1 KIP2 MDA6 PIC1 PRAD1 RB1 RBBP3 SDI1 TFDP1 TFDP2 WAF1 p27	Homo sapiens (human)
Malate-aspartate shuttle	Aspartate aminotransferase, cytoplasmic Aspartate aminotransferase, mitochondrial Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial Malate dehydrogenase, cytoplasmic Malate dehydrogenase, mitochondrial Mitochondrial 2-oxoglutarate/malate carrier protein Mitochondrial glutamate carrier 1 Mitochondrial glutamate carrier 2	O75746 P00505 P17174 P40925 P40926 Q02978 Q9H1K4 Q9H936 Q9UJS0	AGC1 ARALAR1 GC1 GC2 GOT1 GOT2 KYAT4 MDH1 MDH2 MDHA SLC20A4 SLC25A11 SLC25A12 SLC25A13 SLC25A18 SLC25A22	Homo sapiens (human)
Signaling by BMP	Activin receptor type-1-like Activin receptor type-2A Activin receptor type-2B Anti-Muellerian hormone type-2 receptor Bone morphogenetic protein 10 Bone morphogenetic protein 2 Bone morphogenetic protein receptor type-1A Bone morphogenetic protein receptor type-1B Bone morphogenetic protein receptor type-2 Cerberus Chordin-like protein 1 E3 ubiquitin-protein ligase SMURF1 E3 ubiquitin-protein ligase SMURF2 Follistatin-related protein 1 Gremlin-2 Growth/differentiation factor 2 Inhibin alpha chain Inhibin beta A chain Mothers against decapentaplegic homolog 1 Mothers against decapentaplegic homolog 4 Mothers against decapentaplegic homolog 5 Mothers against decapentaplegic homolog 6 Mothers against decapentaplegic homolog 7 Mothers against decapentaplegic homolog 9 Muellerian-inhibiting factor Noggin Ski oncogene Transforming growth factor beta receptor type 3 Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D3 Zinc finger FYVE domain-containing protein 16	O00238 O15105 O15198 O43541 O95393 O95813 P03971 P05111 P08476 P12643 P12755 P27037 P36894 P37023 P51668 P61077 Q03167 Q12841 Q13253 Q13485 Q13705 Q13873 Q15797 Q16671 Q7Z3T8 Q99717 Q9BU40 Q9H772 Q9HAU4 Q9HCE7 Q9UK05	ACVR2 ACVR2A ACVR2B ACVRL1 ACVRLK1 ACVRLK3 ALK1 ALK3 AMH AMHR AMHR2 BMP10 BMP2 BMP2A BMP9 BMPR1A BMPR1B BMPR2 BSP1 CER1 CHRDL1 CKTSF1B2 DAND3 DAND4 DPC4 FRP FSTL1 GDF2 GREM2 INHA INHBA KIAA0305 KIAA1625 MADH1 MADH4 MADH5 MADH6 MADH7 MADH8 MADH9 MADR1 MIF MISR2 NOG NRLN1 PPH1 PRDC SFT SKI SMAD1 SMAD4 SMAD5 SMAD6 SMAD7 SMAD8 SMAD9 SMURF1 SMURF2 TGFBR3 UBC5A UBC5C UBCH5 UBCH5A UBCH5C UBE2D1 UBE2D3 ZFYVE16	Homo sapiens (human)
Signaling by cytosolic FGFR1 fusion mutants	Breakpoint cluster region protein Centrosomal protein 43 Cleavage and polyadenylation specificity factor subunit 6 FGFR1 oncogene partner 2 GRB2-associated-binding protein 2 Homeobox protein cut-like 1 Leucine-rich repeat flightless-interacting protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Transcription intermediary factor 1-alpha Unconventional myosin-XVIIIa Zinc finger MYM-type protein 2	O15164 O95684 P11274 P27986 P39880 P40763 P42224 P42229 P42336 P51692 Q16630 Q32MZ4 Q92614 Q9NVK5 Q9UBW7 Q9UQC2	APRF BCR BCR1 CD245 CEP43 CFIM68 CPSF6 CUTL1 CUX1 D22S11 FGFR1OP FGFR1OP2 FIM FOP GAB2 GCF2 GRB1 KIAA0216 KIAA0571 LRRFIP1 MYO18A MYSPDZ PIK3CA PIK3R1 RAMP RNF82 STAT1 STAT3 STAT5 STAT5A STAT5B TIAF1 TIF1 TIF1A TRIM24 TRIP ZMYM2 ZNF198	Homo sapiens (human)
Activated NTRK3 signals through PI3K	Insulin receptor substrate 1 NT-3 growth factor receptor Neurotrophin-3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proto-oncogene tyrosine-protein kinase Src	P12931 P20783 P27986 P35568 P42336 Q16288	GRB1 IRS1 NTF3 NTRK3 PIK3CA PIK3R1 SRC SRC1 TRKC	Homo sapiens (human)
Frs2-mediated activation	14-3-3 protein beta/alpha Beta-nerve growth factor Crk-like protein Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Fibroblast growth factor receptor substrate 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Rap guanine nucleotide exchange factor 1 Ras-related protein Rap-1A Serine/threonine-protein kinase B-raf	P01138 P15056 P27361 P28482 P31946 P36507 P46109 P62834 Q02750 Q13905 Q8WU20	BRAF BRAF1 CRKL ERK1 ERK2 FRS2 GRF2 KREV1 MAP2K1 MAP2K2 MAPK1 MAPK3 MEK1 MEK2 MKK2 NGF NGFB PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2 RAFB1 RAP1A RAPGEF1 YWHAB	Homo sapiens (human)
SCF-beta-TrCP mediated degradation of Emi1	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cell division cycle protein 20 homolog Cullin-1 F-box only protein 5 F-box/WD repeat-containing protein 1A Fizzy-related protein homolog Polyubiquitin-B Polyubiquitin-C Proteasomal ubiquitin receptor ADRM1 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 S-phase kinase-associated protein 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00231 O00232 O00487 O14818 O43242 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28066 P28070 P28072 P28074 P35998 P43686 P48556 P49720 P49721 P51665 P60896 P60900 P62191 P62195 P62333 P62979 P62987 P63208 Q12834 Q13200 Q13616 Q15008 Q16186 Q99436 Q99460 Q9UKT4 Q9UM11 Q9UNM6 Q9Y297	ADRM1 BTRC BTRCP C7orf76 CDC20 CDH1 CUL1 DSS1 EMC19 EMI1 FBW1A FBX5 FBXO5 FBXW1A FYR FZR FZR1 GP110 HC2 HC3 HC8 HC9 HSPC KIAA0107 KIAA1242 LMPX LMPY MB1 MIP224 MOV34L MSS1 NU OCP2 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RPS27A SEM1 SHFDG1 SHFM1 SKP1 SKP1A SUG1 SUG2 TBP1 TBP7 TCEB1L TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Z	Homo sapiens (human)
Serotonin Neurotransmitter Release Cycle	Complexin-1 Liprin-alpha-1 Liprin-alpha-2 Liprin-alpha-3 Liprin-alpha-4 Peripheral-type benzodiazepine receptor-associated protein 1 Protein unc-13 homolog B Ras-related protein Rab-3A Regulating synaptic membrane exocytosis protein 1 Synapsin-1 Synapsin-2 Synapsin-3 Synaptic vesicular amine transporter Synaptosomal-associated protein 25 Synaptotagmin-1 Syntaxin-1A Vesicle-associated membrane protein 2	O14795 O14810 O14994 O75145 O75334 O75335 O95153 P17600 P20336 P21579 P60880 P63027 Q05940 Q13136 Q16623 Q86UR5 Q92777	BZRAP1 CPLX1 KIAA0340 KIAA0612 KIAA0654 KIAA0897 LIP1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RAB3IP2 RBP1 RIM1 RIMBP1 RIMS1 SLC18A2 SNAP SNAP25 STX1 STX1A SVMT SVP65 SYB2 SYN1 SYN2 SYN3 SYT SYT1 TSPOAP1 UNC13 UNC13B VAMP2 VMAT2	Homo sapiens (human)
MPS IIIB - Sanfilippo syndrome B	Alpha-N-acetylglucosaminidase	P54802	NAGLU UFHSD1	Homo sapiens (human)
Dimerization of procaspase-8	Caspase-8 FAS-associated death domain protein Receptor-interacting serine/threonine-protein kinase 1 TNF receptor-associated factor 2 Tumor necrosis factor ligand superfamily member 10 Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor receptor superfamily member 10A Tumor necrosis factor receptor superfamily member 10B Tumor necrosis factor receptor superfamily member 6 Tumor necrosis factor receptor type 1-associated DEATH domain protein	O00220 O14763 P25445 P48023 P50591 Q12933 Q13158 Q13546 Q14790 Q15628	APO2 APO2L APT1 APT1LG1 CASP8 CD95L DR4 DR5 FADD FAS FAS1 FASL FASLG KILLER MCH5 MORT1 RIP RIP1 RIPK1 TNFRSF10A TNFRSF10B TNFRSF6 TNFSF10 TNFSF6 TRADD TRAF2 TRAIL TRAILR1 TRAILR2 TRAP3 TRICK2 ZTNFR9	Homo sapiens (human)
RAB geranylgeranylation	Geranylgeranyl transferase type-2 subunit alpha Geranylgeranyl transferase type-2 subunit beta Protein tyrosine phosphatase type IVA 2 Rab proteins geranylgeranyltransferase component A 1 Rab proteins geranylgeranyltransferase component A 2 Ras-related protein Rab-10 Ras-related protein Rab-11A Ras-related protein Rab-11B Ras-related protein Rab-12 Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-15 Ras-related protein Rab-17 Ras-related protein Rab-18 Ras-related protein Rab-19 Ras-related protein Rab-1A Ras-related protein Rab-1B Ras-related protein Rab-20 Ras-related protein Rab-21 Ras-related protein Rab-22A Ras-related protein Rab-23 Ras-related protein Rab-24 Ras-related protein Rab-25 Ras-related protein Rab-26 Ras-related protein Rab-27A Ras-related protein Rab-27B Ras-related protein Rab-2A Ras-related protein Rab-2B Ras-related protein Rab-30 Ras-related protein Rab-31 Ras-related protein Rab-32 Ras-related protein Rab-33A Ras-related protein Rab-33B Ras-related protein Rab-34 Ras-related protein Rab-35 Ras-related protein Rab-36 Ras-related protein Rab-37 Ras-related protein Rab-38 Ras-related protein Rab-39A Ras-related protein Rab-39B Ras-related protein Rab-3A Ras-related protein Rab-3B Ras-related protein Rab-3C Ras-related protein Rab-3D Ras-related protein Rab-40A Ras-related protein Rab-40B Ras-related protein Rab-40C Ras-related protein Rab-41 Ras-related protein Rab-42 Ras-related protein Rab-43 Ras-related protein Rab-44 Ras-related protein Rab-4A Ras-related protein Rab-4B Ras-related protein Rab-5A Ras-related protein Rab-5B Ras-related protein Rab-5C Ras-related protein Rab-6A Ras-related protein Rab-6B Ras-related protein Rab-7L1 Ras-related protein Rab-7a Ras-related protein Rab-7b Ras-related protein Rab-8A Ras-related protein Rab-8B Ras-related protein Rab-9A Ras-related protein Rab-9B	A4D1S5 O00194 O14966 O95716 O95755 P20336 P20337 P20338 P20339 P20340 P24386 P26374 P51148 P51149 P51151 P51153 P51159 P53611 P57729 P57735 P59190 P61006 P61018 P61019 P61020 P61026 P61106 P62491 P62820 Q12829 Q12974 Q13636 Q13637 Q14088 Q14964 Q15286 Q15771 Q15907 Q5JT25 Q6IQ22 Q7Z6P3 Q86YS6 Q8N4Z0 Q8WUD1 Q8WXH6 Q92696 Q92930 Q969Q5 Q96AH8 Q96AX2 Q96DA2 Q96E17 Q96S21 Q9BZG1 Q9H082 Q9H0T7 Q9H0U4 Q9NP72 Q9NP90 Q9NRW1 Q9NX57 Q9UL25 Q9UL26 Q9ULC3 Q9ULW5	CATX8 CHM CHML GGTB GOV KIAA0118 MEL PRL2 PTP4A2 PTPCAAX2 RAB1 RAB10 RAB11 RAB11A RAB11B RAB12 RAB13 RAB14 RAB15 RAB16 RAB17 RAB18 RAB19 RAB19B RAB1A RAB1B RAB1C RAB2 RAB20 RAB21 RAB22 RAB22A RAB22B RAB23 RAB24 RAB25 RAB26 RAB27 RAB27A RAB27B RAB29 RAB2A RAB2B RAB30 RAB31 RAB32 RAB33A RAB33B RAB34 RAB35 RAB36 RAB37 RAB38 RAB39 RAB39A RAB39B RAB3A RAB3B RAB3C RAB3D RAB4 RAB40A RAB40B RAB40C RAB41 RAB42 RAB43 RAB44 RAB4A RAB4B RAB5 RAB5A RAB5B RAB5C RAB6 RAB6A RAB6B RAB7 RAB7A RAB7B RAB7L1 RAB8 RAB8A RAB8B RAB9 RAB9A RAB9B RAB9L RABGGTA RABGGTB RABL RABS10 RAH RARL RASL8C RAY REP1 REP2 SEC4L TCD YPT3	Homo sapiens (human)

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