GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **1226 - 1250** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	GlyTouCan ID
RNA Polymerase I Transcription Initiation	CDK-activating kinase assembly factor MAT1 Chromodomain-helicase-DNA-binding protein 3 Chromodomain-helicase-DNA-binding protein 4 Cyclin-H Cyclin-dependent kinase 7 DNA excision repair protein ERCC-6 DNA-directed RNA polymerase I subunit RPA12 DNA-directed RNA polymerase I subunit RPA1 DNA-directed RNA polymerase I subunit RPA2 DNA-directed RNA polymerase I subunit RPA34 DNA-directed RNA polymerase I subunit RPA43 DNA-directed RNA polymerase I subunit RPA49 DNA-directed RNA polymerases I and III subunit RPAC1 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone deacetylase 1 Histone deacetylase 2 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EHMT2 Metastasis-associated protein MTA1 Metastasis-associated protein MTA2 Metastasis-associated protein MTA3 Methyl-CpG-binding domain protein 3 Nucleolar transcription factor 1 Protein POLR1D, isoform 2 RNA polymerase I-specific transcription initiation factor RRN3 TATA box-binding protein-associated factor RNA polymerase I subunit A TATA box-binding protein-associated factor RNA polymerase I subunit B TATA box-binding protein-associated factor RNA polymerase I subunit C TATA box-binding protein-associated factor RNA polymerase I subunit D TATA-box-binding protein Transcription termination factor 1 Transcriptional repressor p66-alpha Transcriptional repressor p66-beta	O15160 O15446 O94776 O95602 O95983 P0DPB5 P17480 P18074 P19388 P19447 P20226 P32780 P50613 P51946 P51948 P52434 P53803 P61218 P62875 Q03468 Q09028 Q12873 Q13330 Q13547 Q13888 Q13889 Q14839 Q15361 Q15572 Q15573 Q16576 Q3B726 Q53T94 Q6ZYL4 Q86YP4 Q8WXI9 Q92759 Q92769 Q92830 Q92831 Q96KQ7 Q9BTC8 Q9GZS1 Q9H5J8 Q9H9Y6 Q9NYV6 Q9P1U0	ASE1 BAT8 BTF2 BTF2P44 C6orf175 C6orf30 CAK CAK1 CAP35 CAST CCNH CD3EAP CDK7 CDKN7 CHD3 CHD4 CSB EHMT2 ERCC2 ERCC3 ERCC6 G9A GATAD2A GATAD2B GCN5 GCN5L2 GTF2D1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 HDAC1 HDAC2 JOSD3 KAT2A KAT2B KIAA1150 KIAA1266 KMT1C MAT1 MBD3 MNAT1 MO15 MTA1 MTA1L1 MTA2 MTA3 NG36 PAF49 PAF53 PCAF PID POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L POLRF PRAF1 RBAP46 RBAP48 RBBP4 RBBP7 RNF66 RPA12 RPD3L1 RRN3 STK1 TAF1A TAF1B TAF1C TAF1D TBP TF2D TFIID TIFIA TTDA TTF1 TWISTNB UBF UBF1 UBTF XPB XPBC XPD XPDC ZNRD1
IRAK4 deficiency (TLR5)	Flagellin Interleukin-1 receptor-associated kinase 4 Myeloid differentiation primary response protein MyD88 Toll-like receptor 10 Toll-like receptor 5	O60602 P04949 Q99836 Q9BXR5 Q9NWZ3	IRAK4 MYD88 TIL3 TLR10 TLR5 flaF fliC hag
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 Cyclin-dependent kinase 6 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase inhibitor 1C G1/S-specific cyclin-D1 G1/S-specific cyclin-D2 G1/S-specific cyclin-D3 G1/S-specific cyclin-E1 G1/S-specific cyclin-E2 Retinoblastoma-associated protein Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F2 Transcription factor E2F3	O00716 O96020 P06400 P11802 P24385 P24864 P24941 P30279 P30281 P38936 P46527 P49918 Q00534 Q01094 Q14186 Q14188 Q14209	BCL1 CAP20 CCND1 CCND2 CCND3 CCNE CCNE1 CCNE2 CDK2 CDK4 CDK6 CDKN1 CDKN1A CDKN1B CDKN1C CDKN2 CDKN6 CIP1 DP1 DP2 E2F1 E2F2 E2F3 KIAA0075 KIP1 KIP2 MDA6 PIC1 PRAD1 RB1 RBBP3 SDI1 TFDP1 TFDP2 WAF1 p27
RHOD GTPase cycle	A-kinase anchor protein 12 Adenosine 5'-monophosphoramidase HINT2 Alpha-actinin-1 Caveolin-1 Cell surface glycoprotein MUC18 Copine-8 DEP domain-containing protein 1B Delta(14)-sterol reductase LBR Drebrin EF-hand domain-containing protein D2 Emerin Extended synaptotagmin-1 F-actin-capping protein subunit beta Filamin-A-interacting protein 1 Gamma-adducin Golgin subfamily A member 8R Inner nuclear membrane protein Man1 Lamin-B1 Lamina-associated polypeptide 2, isoforms beta/gamma Membrane-associated progesterone receptor component 2 Metalloreductase STEAP3 Motile sperm domain-containing protein 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Plexin-A1 Plexin-B1 Protein ERGIC-53 Protein diaphanous homolog 1 Protein diaphanous homolog 3 Rabankyrin-5 Rac GTPase-activating protein 1 Ras-related protein Rab-7a Rho GTPase-activating protein 12 Rho GTPase-activating protein 17 Rho GTPase-activating protein 1 Rho GTPase-activating protein 21 Rho GTPase-activating protein 26 Rho GTPase-activating protein 32 Rho GTPase-activating protein 35 Rho GTPase-activating protein 39 Rho GTPase-activating protein 5 Rho-related GTP-binding protein RhoD Serine/threonine-protein kinase PAK 5 Serine/threonine-protein kinase PAK 6 Serine/threonine-protein kinase VRK2 Sodium bicarbonate cotransporter 3 Starch-binding domain-containing protein 1 Torsin-1A-interacting protein 1 Vang-like protein 1 Vesicle-associated membrane protein 3 Vesicle-associated membrane protein-associated protein B/C WASP homolog-associated protein with actin, membranes and microtubules	A7KAX9 I6L899 O00212 O00459 O15173 O43157 O60610 O95210 O95292 P12814 P20700 P27986 P42167 P43121 P47756 P49257 P50402 P51149 Q02952 Q03135 Q07960 Q13017 Q14739 Q15836 Q16643 Q5JTV8 Q5T5U3 Q658P3 Q68EM7 Q7Z7B0 Q86Y07 Q86YQ8 Q8IWW6 Q8NHP6 Q8TAA9 Q8TF30 Q8WUY9 Q96C19 Q9BSJ8 Q9BX68 Q9C0H5 Q9H0H5 Q9NQU5 Q9NRY4 Q9NSV4 Q9P286 Q9P2R3 Q9UEY8 Q9UIW2 Q9UNA1 Q9Y2U8 Q9Y6M7	ACTN1 ADD3 ADDL AKAP12 AKAP250 ANKFY1 ANKHZN ARHD ARHGAP1 ARHGAP10 ARHGAP12 ARHGAP17 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP5 BT CAPZB CAV CAV1 CDC42GAP CPNE8 D0S117E DBN1 DEPDC1B DG6 DIAP1 DIAP3 DIAPH1 DIAPH3 EDMD EFHD2 EMD ERGIC53 ESYT1 F5F8D FAM62A FILIP1 GOLGA8R GRAF GRB1 GRF1 GRIT GRLF1 HINT2 KIAA0407 KIAA0621 KIAA0712 KIAA0747 KIAA1255 KIAA1264 KIAA1275 KIAA1424 KIAA1478 KIAA1688 KIAA1722 KIAA1971 LAP1 LAP2 LBR LEMD3 LMAN1 LMN2 LMNB LMNB1 MAN1 MBC2 MCAM MGCRACGAP MOSPD2 MUC18 NBC2 NBC2B NBC3 NBCn1 NOV OPHN1L P190A PAK5 PAK6 PAK7 PGRMC2 PIK3R1 PIK3R2 PLXN1 PLXN5 PLXNA1 PLXNB1 PMBP RAB7 RAB7A RACGAP1 RHOD RHOGAP1 RHOGAP5 RICH1 RICS SBC2 SEP SLC4A6 SLC4A7 STA STB2 STBD1 STEAP3 SWS1 SYB3 TMPO TOR1AIP1 TSAP6 VAMP3 VANGL1 VAPB VRK2 WHAMM WHDC1 XTP8 p190ARHOGAP
Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS)	UDP-N-acetylglucosamine transporter	Q9Y2D2	SLC35A3
Regulation of TP53 Activity through Phosphorylation	5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 ATR-interacting protein Aurora kinase A Aurora kinase B BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Casein kinase II subunit alpha' Casein kinase II subunit alpha Casein kinase II subunit beta Cell cycle checkpoint control protein RAD9A Cell cycle checkpoint control protein RAD9B Cell cycle checkpoint protein RAD17 Cell cycle checkpoint protein RAD1 Cellular tumor antigen p53 Checkpoint protein HUS1 Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 2 Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 2-binding protein 1 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Dual specificity tyrosine-phosphorylation-regulated kinase 2 E3 ubiquitin-protein ligase Mdm2 EKC/KEOPS complex subunit TP53RK Exonuclease 1 FACT complex subunit SPT16 FACT complex subunit SSRP1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Homeodomain-interacting protein kinase 1 Homeodomain-interacting protein kinase 2 MAP kinase-activated protein kinase 5 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 NUAK family SNF1-like kinase 1 Nibrin Nucleolar complex protein 2 homolog Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Serine/threonine-protein kinase ATR Serine/threonine-protein kinase Chk1 Serine/threonine-protein kinase Chk2 Serine/threonine-protein kinase PLK3 Serine/threonine-protein kinase STK11 TATA-binding protein-associated factor 2N TATA-box-binding protein Targeting protein for Xklp2 Transcription initiation factor TFIID subunit 1-like Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 11 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 3 Transcription initiation factor TFIID subunit 4 Transcription initiation factor TFIID subunit 4B Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 7-like Transcription initiation factor TFIID subunit 7 Transcription initiation factor TFIID subunit 9 Transcription initiation factor TFIID subunit 9B Tumor protein p53-inducible nuclear protein 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00268 O14757 O14965 O15151 O43741 O60285 O60671 O60921 O60934 O75943 O96017 P04637 P0CG47 P0CG48 P15927 P19784 P20226 P20248 P21675 P24941 P27694 P35244 P35249 P35250 P38398 P40937 P40938 P49848 P49959 P51530 P54132 P54619 P54646 P62979 P62987 P67870 P68400 P78396 Q00535 Q00987 Q08945 Q12962 Q13131 Q13315 Q13472 Q13526 Q13535 Q14191 Q15078 Q15542 Q15543 Q15544 Q15545 Q15759 Q15831 Q16514 Q16539 Q16594 Q5H9L4 Q5VWG9 Q6P1X5 Q6WBX8 Q86Z02 Q8IW41 Q8IZX4 Q8WXE1 Q92547 Q92630 Q92750 Q92804 Q92878 Q92993 Q96A56 Q96E14 Q96GD4 Q96S44 Q99638 Q99708 Q99728 Q9BSD3 Q9BX63 Q9H2X6 Q9H4B4 Q9H9A7 Q9HBM6 Q9UGI9 Q9UGJ0 Q9ULW0 Q9UQ84 Q9Y3T9 Q9Y478 Q9Y5B9	AGS1 AIK AIK2 AIM1 AIRK1 AIRK2 AMPK AMPK1 AMPK2 AMPKG3 ARK1 ARK2 ARK5 ATM ATR ATRIP AURA AURKA AURKB AYK1 BA2R BACH1 BARD1 BLM BRCA1 BRIP1 BTAK C12orf32 C16orf75 C20orf1 C20orf2 C20orf64 C9orf76 CCG1 CCGS CCN1 CCNA CCNA1 CCNA2 CDK2 CDK5 CDK5R CDK5R1 CDKN2 CDKN5 CDS1 CHEK1 CHEK2 CHK1 CHK2 CIF150 CK2A1 CK2A2 CK2N CNK CSBP CSBP1 CSBP2 CSNK2A1 CSNK2A2 CSNK2B CSPB1 CTIP DIL2 DNA2 DNA2L DYRK2 EXO1 EXOI FACT140 FACT80 FACTP140 FANCJ FNK FRP1 G5A GTF2D1 HCA519 HEX1 HIPK1 HIPK2 HNGS1 HTATIP HUS1 IAK1 KAT5 KIAA0083 KIAA0259 KIAA0537 KIAA0630 LKB1 MAPK11 MAPK14 MAPKAPK5 MDM2 MDM4 MDMX MRE11 MRE11A MXI2 MYAK NBAK2 NBN NBS NBS1 NCK5A NIR NOC2L NUAK1 OMPHK1 P53 P53DINP1 P95 PIN1 PJS PLK3 PRAK PRK PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRKM11 PRPK PSSALRE R24L RAD1 RAD17 RAD50 RAD53 RAD9A RAD9B RBBP8 RBP56 REC1 RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC2 RFC3 RFC4 RFC5 RHINO RHNO1 RMI1 RMI2 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A SAPK2 SAPK2A SAPK2B SIP SSRP1 STK1 STK11 STK12 STK15 STK5 STK6 SUPT16H TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1L TAF2 TAF2A TAF2B TAF2C TAF2C1 TAF2C2 TAF2D TAF2E TAF2F TAF2G TAF2H TAF2I TAF2J TAF2K TAF2N TAF2Q TAF3 TAF4 TAF4A TAF4B TAF5 TAF6 TAF7 TAF7L TAF9 TAF9B TAF9L TAFII105 TAFII130 TAFII135 TAFII18 TAFII20 TAFII30 TAFII31 TAFII55 TAFII70 TBP TF2D TFIID TIP60 TOP3 TOP3A TOPBP1 TP53 TP53INP1 TP53RK TPX2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WRN
Endogenous sterols	24-hydroxycholesterol 7-alpha-hydroxylase Adrenodoxin, mitochondrial Aromatase Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Aryl hydrocarbon receptor repressor Aryl hydrocarbon receptor Bile acid receptor Cholesterol 24-hydroxylase Cholesterol side-chain cleavage enzyme, mitochondrial Cytochrome P450 11B1, mitochondrial Cytochrome P450 11B2, mitochondrial Cytochrome P450 1B1 Cytochrome P450 4V2 Cytochrome P450 7A1 Cytochrome P450 7B1 Ferredoxin-2, mitochondrial Lanosterol 14-alpha demethylase NADPH Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Pro-opiomelanocortin Retinoic acid receptor RXR-alpha Steroid 21-hydroxylase Sterol 26-hydroxylase, mitochondrial	A9YTQ3 O75881 P01189 P05108 P08686 P10109 P11511 P15538 P19099 P19793 P22570 P22680 P27540 P35869 Q02318 Q15596 Q15788 Q16678 Q16850 Q6P4F2 Q6ZWL3 Q96RI1 Q9HBZ2 Q9NYL5 Q9Y6A2	ADX ADXR AHR AHRR ARNT ARNT2 ARO1 BAR BHLHE1 BHLHE2 BHLHE74 BHLHE75 BHLHE76 BHLHE77 CYAR CYP11A CYP11A1 CYP11B1 CYP11B2 CYP19 CYP19A1 CYP1B1 CYP21 CYP21A2 CYP21B CYP27 CYP27A1 CYP39A1 CYP46 CYP46A1 CYP4V2 CYP51 CYP51A1 CYP7 CYP7A1 CYP7B1 FDX1 FDX1L FDX2 FDXR FXR HRR1 KIAA0307 KIAA1234 NCOA1 NCOA2 NR1H4 NR2B1 POMC RIP14 RXRA S11BH SRC1 SRC2 TIF2
Retrograde transport at the Trans-Golgi-Network	ADP-ribosylation factor-like protein 1 ADP-ribosylation factor-related protein 1 Alpha-soluble NSF attachment protein Arfaptin-2 Beta-soluble NSF attachment protein Cation-dependent mannose-6-phosphate receptor Cation-independent mannose-6-phosphate receptor Conserved oligomeric Golgi complex subunit 1 Conserved oligomeric Golgi complex subunit 2 Conserved oligomeric Golgi complex subunit 3 Conserved oligomeric Golgi complex subunit 4 Conserved oligomeric Golgi complex subunit 5 Conserved oligomeric Golgi complex subunit 6 Conserved oligomeric Golgi complex subunit 7 Conserved oligomeric Golgi complex subunit 8 GRIP and coiled-coil domain-containing protein 1 GRIP and coiled-coil domain-containing protein 2 Gamma-soluble NSF attachment protein Golgin subfamily A member 1 Golgin subfamily A member 4 Guanine nucleotide exchange factor subunit RIC1 N-alpha-acetyltransferase 30 N-alpha-acetyltransferase 35, NatC auxiliary subunit N-alpha-acetyltransferase 38, NatC auxiliary subunit Perilipin-3 Protein SYS1 homolog RAB6A-GEF complex partner protein 2 Rab9 effector protein with kelch motifs Ras-related protein Rab-43 Ras-related protein Rab-6A Ras-related protein Rab-6B Ras-related protein Rab-9A Ras-related protein Rab-9B Rho-related BTB domain-containing protein 3 Short coiled-coil protein Syntaxin-10 Syntaxin-16 Syntaxin-6 TATA element modulatory factor Trans-Golgi network integral membrane protein 2 USP6 N-terminal-like protein Vacuolar protein sorting-associated protein 51 homolog Vacuolar protein sorting-associated protein 52 homolog Vacuolar protein sorting-associated protein 53 homolog Vacuolar protein sorting-associated protein 54 Vesicle transport through interaction with t-SNAREs homolog 1A Vesicle-associated membrane protein 3 Vesicle-associated membrane protein 4 Vesicle-fusing ATPase	O14662 O43493 O43752 O60499 O60664 O75379 O94955 P11717 P20340 P20645 P40616 P46459 P51151 P53365 P54920 P82094 P83436 Q13439 Q13795 Q14746 Q147X3 Q15836 Q4ADV7 Q5VIR6 Q5VZE5 Q7Z6M1 Q86YS6 Q8IWJ2 Q8N1B4 Q8N2H4 Q8WTW3 Q92546 Q92738 Q92805 Q96AJ9 Q96CN9 Q96JB2 Q96MW5 Q99747 Q9BRA0 Q9H115 Q9H9E3 Q9NP90 Q9NRW1 Q9P1Q0 Q9UID3 Q9UIL1 Q9UP83 Q9Y2V7	ANG2 ARA160 ARFIP2 ARFRP1 ARL1 ARP1 C11orf2 C11orf3 C14orf35 C20orf169 CIP150 COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8 EGAP FFR GCC1 GCC2 GOLGA1 GOLGA4 GOLTC1 GTC90 HCC8 IGF2R KIAA0019 KIAA0258 KIAA0336 KIAA0878 KIAA1134 KIAA1381 KIAA1432 LDLB LDLC LSMD1 M6PR M6PRBP1 MAK10 MAK3 MAK31 MPR46 MPRD MPRI NAA30 NAA35 NAA38 NAPA NAPB NAPG NAT12 NSF PFAAP2 PLIN3 POR1 RAB41 RAB43 RAB6 RAB6A RAB6B RAB9 RAB9A RAB9B RAB9L RAB9P40 RABEPK RANBP2L4 RGP1 RHOBTB3 RIC1 SACM2L SCOC SCOCO SEC34 SNAPA SNAPB SNAPG STX10 STX16 STX6 SYB3 SYN10 SYS1 TGN46 TGN51 TGOLN2 TIP47 TMF1 USP6NL VAMP3 VAMP4 VPS51 VPS52 VPS53 VPS54 VTI1A
SHC1 events in ERBB2 signaling	Epidermal growth factor receptor GTPase HRas GTPase NRas Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein kinase C alpha type Protein kinase C delta type Protein kinase C epsilon type Receptor tyrosine-protein kinase erbB-2 SHC-transforming protein 1 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 12	O14511 O14944 P00533 P01111 P01112 P01133 P04626 P17252 P29353 P35070 P56975 Q02156 Q02297 Q05209 Q05655 Q07889 Q8WWG1 Q99075	BTC DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GGF HBEGF HEGFL HER1 HER2 HGL HRAS HRAS1 HRGA MLN19 NDF NEU NGL NRAS NRG1 NRG2 NRG3 NRG4 NTAK PKCA PKCD PKCE PRKACA PRKCA PRKCD PRKCE PTPN12 SHC SHC1 SHCA SMDF SOS1
XBP1(S) activates chaperone genes	ADP-ribosylation factor GTPase-activating protein 1 ATP-dependent DNA helicase DDX11 Alpha-adducin CXXC-type zinc finger protein 1 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 Cullin-7 Cytosolic phospholipase A2 beta DnaJ homolog subfamily B member 11 DnaJ homolog subfamily B member 9 DnaJ homolog subfamily C member 3 Dynactin subunit 1 E3 ubiquitin-protein ligase synoviolin ER degradation-enhancing alpha-mannosidase-like protein 1 ER lumen protein-retaining receptor 3 Exostosin-like 1 Exostosin-like 2 Exostosin-like 3 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 Glycogen synthase kinase-3 alpha Golgi SNAP receptor complex member 2 Guanine nucleotide-exchange factor SEC12 Hepatoma-derived growth factor Hypoxia up-regulated protein 1 Kelch domain-containing protein 3 Myeloid-derived growth factor Peptidyl-prolyl cis-trans isomerase FKBP14 Prelamin-A/C Protein YIF1A Protein disulfide-isomerase A5 Protein disulfide-isomerase A6 Protein transport protein Sec31A Putative deoxyribonuclease TATDN2 SHC-transforming protein 1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Signal recognition particle receptor subunit alpha Signal recognition particle receptor subunit beta Stress-associated endoplasmic reticulum protein 1 Sulfotransferase 1A3 Talin-1 Testis-specific Y-encoded-like protein 2 Translocon-associated protein subunit alpha Tripeptidyl-peptidase 1 V-type proton ATPase subunit d 1 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial WD repeat domain phosphoinositide-interacting protein 1 Wolframin Zinc finger and BTB domain-containing protein 17	O14595 O14653 O14773 O43731 O43909 O76024 O94979 O95070 P02545 P08240 P0C869 P0DMM9 P29353 P35611 P43307 P49748 P49840 P51858 P61421 Q06210 Q13105 Q13217 Q14203 Q14554 Q14999 Q15084 Q15173 Q5MNZ9 Q86TM6 Q8N6T3 Q92611 Q92935 Q93075 Q969H8 Q96FC9 Q9BQ90 Q9H2G4 Q9HCU5 Q9NWM8 Q9P0U4 Q9UBQ6 Q9UBS3 Q9UBS4 Q9Y490 Q9Y4L1 Q9Y5M8 Q9Y6X1	54TM ACADVL ADD1 ADDA ARF1GAP ARFGAP1 ATP6D ATP6V0D1 C19orf10 CDA1 CFP1 CGBP CHL1 CHLR1 CLN2 CTDSP2 CUL7 CXXC1 DCTN1 DDX11 DENTT DNAJB11 DNAJB9 DNAJC3 EDEM EDEM1 EDJ ERD23 ERJ3 ERP5 EXTL EXTL1 EXTL1L EXTL2 EXTL3 EXTR1 EXTR2 FKBP14 FKBP22 GFAT GFPT GFPT1 GOSR2 GRP170 GS27 GSK3A HDGF HDJ9 HMG1L2 HRD1 HSPH4 HYIF1P HYOU1 KDELR3 KIAA0076 KIAA0212 KIAA0218 KIAA0519 KIAA0905 KIAA1027 KIAA1810 KLHDC3 KRG2 LMN1 LMNA MDG1 MIZ1 MYDGF NIF2 ORP150 OS4 P5 P58IPK PCCX1 PDIA5 PDIA6 PDIR PEAS PHF18 PLA2G4B PPP2R5B PREB PRKRI RAMP4 SCP2 SEC12 SEC31A SEC31L1 SERP1 SHC SHC1 SHCA SRPR SRPRA SRPRB SSR1 STM SULT1A3 SYVN1 TATDN2 TLN TLN1 TPP1 TRAPA TSPX TSPYL2 TXNDC7 VLCAD VPATPD WFS1 WIPI1 WIPI49 YIF1 YIF1A ZBTB17 ZNF151 ZNF60
Breakdown of the nuclear lamina	Caspase-6 Lamin-B1	P20700 P55212	CASP6 LMN2 LMNB LMNB1 MCH2
IRAK1 recruits IKK complex	E3 ubiquitin-protein ligase pellino homolog 1 E3 ubiquitin-protein ligase pellino homolog 2 E3 ubiquitin-protein ligase pellino homolog 3 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Interleukin-1 receptor-associated kinase 1 NF-kappa-B essential modulator TNF receptor-associated factor 6 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	O14920 O15111 P51617 P61088 Q13404 Q8N2H9 Q96FA3 Q9HAT8 Q9Y4K3 Q9Y6K9	BLU CHUK CROC1 FIP3 IKBKB IKBKG IKKA IKKB IRAK IRAK1 NEMO PELI1 PELI2 PELI3 PRISM RNF85 TCF16 TRAF6 UBE2N UBE2V UBE2V1 UEV1
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	DNA polymerase beta DNA repair nuclease/redox regulator APEX1	P06746 P27695	APE APE1 APEX APEX1 APX HAP1 POLB REF1
Toll Like Receptor 3 (TLR3) Cascade	TIR domain-containing adapter molecule 1 Toll-like receptor 3	O15455 Q8IUC6	PRVTIRB TICAM1 TLR3 TRIF
Interleukin-7 signaling	Bromodomain and WD repeat-containing protein 1 Cytokine receptor common subunit gamma Cytokine receptor-like factor 2 Cytokine-inducible SH2-containing protein Hepatocyte growth factor Histone H3.1 Histone H3.2 Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin-7 receptor subunit alpha Interleukin-7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 2 Thymic stromal lymphopoietin Transcription activator BRG1 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK3 V(D)J recombination-activating protein 1 V(D)J recombination-activating protein 2	O00459 O14508 O15524 P13232 P14210 P15918 P16871 P23458 P27986 P31785 P35568 P40763 P42229 P51532 P51692 P52333 P55895 P68431 Q71DI3 Q92569 Q969D9 Q9HC73 Q9NSE2 Q9NSI6 Q9Y4H2	APRF BAF190A BRG1 BRWD1 C21orf107 CIS2 CISH CRL2 CRLF2 G18 GRB1 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM HGF HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST2H3A HIST2H3C HIST2H3D HPTA IL2RG IL7 IL7R ILXR IRS1 IRS2 JAK1 JAK1A JAK1B JAK3 PIK3R1 PIK3R2 PIK3R3 RAG1 RAG2 RNF74 SMARCA4 SNF2B SNF2L4 SOCS1 SOCS2 SSI1 SSI2 STAT3 STAT5 STAT5A STAT5B STATI2 TIP3 TSLP TSLPR WDR9
Fructose biosynthesis	Aldo-keto reductase family 1 member B1 Sorbitol dehydrogenase	P15121 Q00796	AKR1B1 ALDR1 ALR2 SORD	G58161NS
Release	Hemagglutinin Matrix protein 1 Matrix protein 2 Neuraminidase Nuclear export protein Nucleoprotein Polymerase acidic protein Polymerase basic protein 2 RNA-directed RNA polymerase catalytic subunit	P03428 P03431 P03433 P03452 P03466 P03468 P03485 P03508 P06821	HA M NA NP NS PA PB1 PB2
TBC/RABGAPs	ADP-ribosylation factor 6 ADP-ribosylation factor-binding protein GGA1 ADP-ribosylation factor-binding protein GGA2 ADP-ribosylation factor-binding protein GGA3 Carabin Gamma-aminobutyric acid receptor-associated protein-like 2 Gamma-aminobutyric acid receptor-associated protein Genome polyprotein Hamartin Microtubule-associated proteins 1A/1B light chain 3B Optineurin Rab GTPase-activating protein 1 Rab GTPase-binding effector protein 1 Rab5 GDP/GTP exchange factor Ras-related protein Rab-11A Ras-related protein Rab-11B Ras-related protein Rab-33A Ras-related protein Rab-33B Ras-related protein Rab-35 Ras-related protein Rab-4A Ras-related protein Rab-5A Ras-related protein Rab-5B Ras-related protein Rab-5C Ras-related protein Rab-6A Ras-related protein Rab-6B Ras-related protein Rab-7a Ras-related protein Rab-7b Ras-related protein Rab-8A Ras-related protein Rab-8B Serine/threonine-protein kinase ULK1 Synaptotagmin-like protein 1 TBC1 domain family member 10A TBC1 domain family member 10B TBC1 domain family member 13 TBC1 domain family member 14 TBC1 domain family member 15 TBC1 domain family member 16 TBC1 domain family member 17 TBC1 domain family member 20 TBC1 domain family member 24 TBC1 domain family member 25 TBC1 domain family member 2A TBC1 domain family member 3 TBC1 domain family member 7 Tuberin	O75385 O95166 P20338 P20339 P20340 P27958 P49815 P51148 P51149 P60520 P61006 P61020 P62330 P62491 Q14088 Q15276 Q15286 Q15907 Q3MII6 Q4KMP7 Q8IV04 Q8IYJ3 Q8IZP1 Q8TBP0 Q8TC07 Q92574 Q92930 Q96AH8 Q96BZ9 Q96CV9 Q9BXI6 Q9BYX2 Q9GZQ8 Q9H082 Q9HA65 Q9NRW1 Q9NVG8 Q9NZ52 Q9P0N9 Q9P2M4 Q9UJ41 Q9UJY4 Q9UJY5 Q9ULP9 Q9Y3P9	ARF6 C20orf140 EPI64 FIP2 FLC3A FLC3B GABARAP GABARAPL2 GEF2 GGA1 GGA2 GGA3 GLC1E HIP7 HYPL KIAA0154 KIAA0243 KIAA0722 KIAA1080 KIAA1171 KIAA1322 MAP1ALC3 MAP1LC3B MEL NRP OATL1 OPTN PARIS1 PP8997 PRC17 RAB11 RAB11A RAB11B RAB1C RAB33A RAB33B RAB35 RAB4 RAB4A RAB5 RAB5A RAB5B RAB5C RAB5EP RAB6 RAB6A RAB6B RAB7 RAB7A RAB7B RAB8 RAB8A RAB8B RABEP1 RABEX5 RABGAP1 RABGEF1 RABL RABPT5 RABPT5A RABS10 RAY SLP1 SYTL1 TBC1D10 TBC1D10A TBC1D10B TBC1D10C TBC1D13 TBC1D14 TBC1D15 TBC1D16 TBC1D17 TBC1D2 TBC1D20 TBC1D24 TBC1D25 TBC1D2A TBC1D3 TBC1D3A TBC1D7 TBC7 TSC TSC1 TSC2 TSC4 ULK1 YPT3
Unwinding of DNA	Cell division control protein 45 homolog DNA helicase MCM8 DNA replication complex GINS protein PSF1 DNA replication complex GINS protein PSF2 DNA replication complex GINS protein PSF3 DNA replication complex GINS protein SLD5 DNA replication licensing factor MCM2 DNA replication licensing factor MCM3 DNA replication licensing factor MCM4 DNA replication licensing factor MCM5 DNA replication licensing factor MCM6 DNA replication licensing factor MCM7	O75419 P25205 P33991 P33992 P33993 P49736 Q14566 Q14691 Q9BRT9 Q9BRX5 Q9UJA3 Q9Y248	BM28 C20orf154 CCNL1 CDC21 CDC45 CDC45L CDC45L2 CDC46 CDC47 CDCL1 GINS1 GINS2 GINS3 GINS4 KIAA0030 KIAA0186 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 PSF1 PSF2 PSF3 SLD5
Galactose catabolism	Galactokinase Galactose-1-phosphate uridylyltransferase Phosphoglucomutase-1 UDP-glucose 4-epimerase	P07902 P36871 P51570 Q14376	GALE GALK GALK1 GALT PGM1	G93924TT
Regulation of signaling by NODAL	Activin receptor type-1B Activin receptor type-1C Activin receptor type-2A Activin receptor type-2B Cerberus Cryptic protein DAN domain family member 5 Left-right determination factor 1 Left-right determination factor 2 Nodal homolog Protein Cripto Putative protein CRIPTO3	O00292 O75610 O95813 P0CG37 P13385 P27037 P36896 P51864 Q13705 Q8N907 Q8NER5 Q96S42	ACVR1B ACVR1C ACVR2 ACVR2A ACVR2B ACVRLK4 ALK4 ALK7 CER1 CER2 CFC1 CKTSF1B3 CRIPTO CRIPTO-1 CRIPTO-3 CRIPTO3 DAND4 DAND5 EBAF GREM3 LEFTA LEFTB LEFTY1 LEFTY2 LEFTYA LEFTYB NODAL SP1 TDGF1 TDGF1P3 TDGF2 TDGF3 TGFB4
FRS-mediated FGFR4 signaling	Beta-klotho Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 GTPase HRas GTPase NRas Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	O43320 O43559 O76093 O95750 P01111 P01112 P05230 P08620 P09038 P10767 P22455 P31371 Q06124 Q07889 Q86Z14 Q8WU20 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF9 FGFA FGFB FGFR4 FRS2 FRS3 HRAS HRAS1 HST HST2 HSTF1 HSTF2 HYPF JTK2 KLB KS3 NRAS PTP2C PTPN11 SHPTP2 SOS1 TKF
Generation of second messenger molecules	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Actin nucleation-promoting factor WAS Ena/VASP-like protein FYN-binding protein 1 GRB2-related adapter protein 2 HLA class II histocompatibility antigen, DP alpha 1 chain HLA class II histocompatibility antigen, DP beta 1 chain HLA class II histocompatibility antigen, DQ alpha 1 chain HLA class II histocompatibility antigen, DQ alpha 2 chain HLA class II histocompatibility antigen, DQ beta 1 chain HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DR alpha chain HLA class II histocompatibility antigen, DR beta 3 chain HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DRB1 beta chain Immunoglobulin superfamily member 2 Linker for activation of T-cells family member 1 Lymphocyte cytosolic protein 2 Protein enabled homolog SH2/SH3 adapter protein NCK1 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 T cell receptor alpha chain constant T cell receptor alpha variable 19 T cell receptor alpha variable 29/delta variable 5 T cell receptor alpha variable 8-4 T cell receptor beta constant 1 T cell receptor beta variable 12-3 T cell receptor beta variable 7-9 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase ITK/TSK Tyrosine-protein kinase Lck Tyrosine-protein kinase ZAP-70 Vasodilator-stimulated phosphoprotein	A0A0A6YYK7 O15117 O43561 O75791 O75914 P01730 P01733 P01737 P01848 P01850 P01903 P01906 P01909 P01911 P01920 P04234 P04435 P04437 P04440 P05538 P06239 P07766 P09693 P13762 P16333 P16885 P19174 P20036 P42768 P43403 P50552 P79483 Q08881 Q13094 Q13153 Q13177 Q30154 Q8N8S7 Q93033 Q9UI08	CD101 CD3D CD3E CD3G CD4 EMT ENAH EVL EWI101 FYB FYB1 GADS GRAP2 GRB2L GRID HLA-DP1A HLA-DP1B HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRA1 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-DXA HLA-DXB HLASB IGSF2 IMD2 ITK LAT LCK LCP2 LYK MENA NCK NCK1 OPHN3 PAK1 PAK2 PAK3 PLC1 PLCG1 PLCG2 RNB6 SLAP130 SRK T3D T3E T3G TCRA TCRBV12S3 TCRBV8S1 TRAC TRAV19 TRAV29DV5 TRAV8-4 TRBC1 TRBV12-3 TRBV7-9 V7 VASP WAS ZAP70
Signaling by Insulin receptor	Insulin receptor Insulin	P01308 P06213	INS INSR
Signaling by ERBB4	Disks large homolog 4 Epidermal growth factor receptor Gamma-aminobutyric acid receptor subunit alpha-1 Gamma-aminobutyric acid receptor subunit beta-1 Gamma-aminobutyric acid receptor subunit beta-2 Gamma-aminobutyric acid receptor subunit beta-3 Gamma-aminobutyric acid receptor subunit gamma-2 Gamma-aminobutyric acid receptor subunit gamma-3 Gamma-aminobutyric acid receptor subunit theta Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor	O14511 O14944 P00533 P01133 P14867 P18505 P18507 P28472 P35070 P47870 P56975 P78352 Q02297 Q8WWG1 Q99075 Q99928 Q9UN88	BTC DLG4 DTR DTS EGF EGFR ERBB ERBB1 EREG GABRA1 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GGF HBEGF HEGFL HER1 HGL HRGA NDF NRG1 NRG2 NRG3 NRG4 NTAK PSD95 SMDF

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