CD28 dependent PI3K/Akt signaling
|
|
|
- AKT1
- AKT2
- AKT3
- C20orf97
- CD28
- CD28LG
- CD28LG1
- CD28LG2
- CD80
- CD86
- COT
- CTMP
- ESTF
- FRAP
- FRAP1
- FRAP2
- FYN
- GBL
- GRB1
- KIAA1999
- LAB7
- LCK
- LST8
- M
- MAP3K14
- MAP3K8
- MAPKAP1
- MIP1
- MLST8
- MTOR
- N
- NIK
- NIPK
- PDK1
- PDPK1
- PIK3CA
- PIK3R1
- PIK3R2
- PIK3R3
- PKB
- PKBG
- PROTOR1
- PRR5
- RAC
- RAFT1
- RAPT1
- RICTOR
- SIN1
- SKIP3
- THEM4
- TRB3
- TRIB3
|
Homo sapiens (human)
|
|
VEGFR2 mediated vascular permeability
|
|
|
- AKT1
- AKT2
- AKT3
- C20orf97
- CALM
- CALM1
- CAM
- CAM1
- CAV
- CAV1
- CDH5
- CTMP
- CTNNA1
- CTNNB
- CTNNB1
- CTNND1
- CTNNG
- DP3
- FRAP
- FRAP1
- FRAP2
- GBL
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- JUP
- KIAA0384
- KIAA1999
- LST8
- M
- MAPKAP1
- MIP1
- MLST8
- MTOR
- N
- NIPK
- NOS3
- OPHN3
- PAK1
- PAK2
- PAK3
- PDK1
- PDPK1
- PKB
- PKBG
- PROTOR1
- PRR5
- RAC
- RAC1
- RAFT1
- RAPT1
- RICTOR
- SIN1
- SKIP3
- TC25
- THEM4
- TRB3
- TRIB3
- VAV
- VAV1
- VAV2
- VAV3
|
Homo sapiens (human)
|
|
Regulation of TP53 Activity through Acetylation
|
|
|
- AKT1
- AKT2
- AKT3
- BP75
- BR140
- BRD1
- BRD7
- BRL
- BRPF1
- BRPF2
- BRPF3
- C1orf149
- CELTIX1
- CENP-28
- CHD3
- CHD4
- EAF6
- EP300
- GATAD2A
- GATAD2B
- HDAC1
- HDAC2
- ING5
- KAT6A
- KIAA1150
- KIAA1286
- MBD3
- MEAF6
- MOZ
- MTA1L1
- MTA2
- MYL
- MYST3
- P300
- P53
- PID
- PKB
- PKBG
- PML
- PP8675
- RAC
- RBAP46
- RBAP48
- RBBP4
- RBBP7
- RNF71
- RPD3L1
- RUNXBP2
- TP53
- TRIM19
- ZNF220
|
Homo sapiens (human)
|
|
FLT3 Signaling
|
|
|
- AKT1
- AKT2
- AKT3
- BCL2L11
- BIM
- CD135
- CDKN1B
- FKHRL1
- FLK2
- FLT3
- FLT3LG
- FOXO3
- FOXO3A
- GAB2
- GADS
- GRAP2
- GRB1
- GRB10
- GRB2L
- GRBIR
- GRID
- HRAS
- HRAS1
- KIAA0207
- KIAA0571
- KIP1
- NRAS
- PIK3CA
- PIK3R1
- PKB
- PKBG
- PTP2C
- PTPN11
- RAC
- SHPTP2
- SOS1
- STK1
- p27
|
Homo sapiens (human)
|
|
Cyclin E associated events during G1/S transition
|
|
|
- AKT1
- AKT2
- AKT3
- BARA
- BHLHD4
- BHLHE39
- C14orf46
- CABLES
- CABLES1
- CAK
- CAK1
- CAP20
- CAP35
- CCNE
- CCNE1
- CCNE2
- CCNH
- CDC25A
- CDK2
- CDK7
- CDKN1
- CDKN1A
- CDKN1B
- CDKN2
- CDKN7
- CIP1
- CXCDC1
- DP1
- DP2
- E2F1
- E2F4
- E2F5
- KIAA2037
- KIP1
- LIN37
- LIN52
- LIN54
- LIN9
- MAT1
- MAX
- MDA6
- MNAT1
- MO15
- MYC
- PIC1
- PKB
- PKBG
- RAC
- RB1
- RB2
- RBAP48
- RBBP3
- RBBP4
- RBL2
- RNF66
- SDI1
- STK1
- TFDP1
- TFDP2
- TGS
- WAF1
- WEE1
- p27
|
Homo sapiens (human)
|
|
Cyclin A:Cdk2-associated events at S phase entry
|
|
|
- AKT1
- AKT2
- AKT3
- BARA
- BHLHD4
- BHLHE39
- C14orf46
- CABLES
- CABLES1
- CAK
- CAK1
- CAP20
- CAP35
- CCN1
- CCNA
- CCNA1
- CCNA2
- CCNH
- CDC25A
- CDC25B
- CDC25HU2
- CDH1
- CDK2
- CDK7
- CDKN1
- CDKN1A
- CDKN1B
- CDKN2
- CDKN7
- CIP1
- CXCDC1
- DP1
- DP2
- E2F1
- E2F4
- E2F5
- FYR
- FZR
- FZR1
- KIAA1242
- KIAA2037
- KIP1
- LIN37
- LIN52
- LIN54
- LIN9
- MAT1
- MAX
- MDA6
- MNAT1
- MO15
- MYC
- PIC1
- PKB
- PKBG
- RAC
- RB1
- RB2
- RBAP48
- RBBP3
- RBBP4
- RBL2
- RNF66
- SDI1
- STK1
- TFDP1
- TFDP2
- TGS
- WAF1
- WEE1
- p27
|
Homo sapiens (human)
|
|
Activation of BAD and translocation to mitochondria
|
|
|
- AKT1
- AKT2
- AKT3
- BAD
- BBC6
- BCL2
- BCL2L8
- BID
- CALNA3
- CNA2
- CNA3
- CNB
- HME1
- PKB
- PKBG
- PPP3CC
- PPP3R1
- RAC
- SFN
- YWHA1
- YWHAB
- YWHAE
- YWHAG
- YWHAH
- YWHAQ
- YWHAZ
|
Homo sapiens (human)
|
|
Regulation of TP53 Degradation
|
|
|
- AKT1
- AKT2
- AKT3
- ATM
- BING2
- C20orf104
- CCN1
- CCNA
- CCNA1
- CCNA2
- CCNG
- CCNG1
- CDC2
- CDC28A
- CDK1
- CDK2
- CDKN1
- CDKN2
- CDKN2A
- CDS1
- CHEK2
- CHK2
- CYCG1
- DAP6
- DAXX
- FRAP
- FRAP1
- FRAP2
- GBL
- GLEA2
- HAUSP
- HCA58
- KIAA0044
- KIAA1999
- LST8
- MAPKAP1
- MDM2
- MDM4
- MDMX
- MIP1
- MLM
- MLST8
- MTOR
- NZF
- P34CDC2
- P53
- PDK1
- PDPK1
- PHF20
- PKB
- PKBG
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5C
- PROTOR1
- PRR5
- RAC
- RAD53
- RAFT1
- RAPT1
- RFFL
- RICTOR
- RNF189
- RNF34
- RNF34L
- RPS27A
- SGK
- SGK1
- SIN1
- TP53
- TZP
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- UBP41
- USP2
- USP7
|
Homo sapiens (human)
|
|
Regulation of TP53 Activity through Association with Co-factors
|
|
|
- AKT1
- AKT2
- AKT3
- ASPP1
- ASPP2
- BANP
- BBP
- BEND1
- BRN3A
- BRN3B
- C20orf104
- GLEA2
- HCA58
- HZF
- IASPP
- KET
- KIAA0771
- NKIP1
- NZF
- P53
- P63
- P73
- P73H
- P73L
- PHF20
- PKB
- PKBG
- POU4F1
- POU4F2
- PPP1R13B
- PPP1R13BL
- PPP1R13L
- RAC
- RAI
- RDC1
- RZF
- SMAR1
- TP53
- TP53BP2
- TP63
- TP73
- TP73L
- TZP
- ZNF385
- ZNF385A
|
Homo sapiens (human)
|
|
G beta:gamma signalling through PI3Kgamma
|
|
|
- AKT1
- AKT2
- AKT3
- ARH12
- ARHA
- C17orf38
- GNB1
- GNB2
- GNB3
- GNB4
- GNB5
- GNG10
- GNG11
- GNG12
- GNG13
- GNG2
- GNG3
- GNG4
- GNG5
- GNG7
- GNG8
- GNG9
- GNGT1
- GNGT10
- GNGT11
- GNGT2
- GNGT3
- GNGT4
- GNGT5
- GNGT7
- GNGT8
- GNGT9
- PDK1
- PDPK1
- PIK3CG
- PIK3R5
- PIK3R6
- PKB
- PKBG
- RAC
- RHO12
- RHOA
|
Homo sapiens (human)
|
|
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
|
|
|
- AKT1
- AKT2
- AKT3
- AREG
- AREGB
- BCL1
- BCL2
- BTC
- CCND1
- CDKN1B
- CRM1
- DTR
- DTS
- EGF
- EGFR
- ELK1
- EPGN
- ERBB
- ERBB1
- EREG
- ERK1
- ERK2
- FAK
- FAK1
- FKHRL1
- FOS
- FOXO3
- FOXO3A
- G0S7
- HBEGF
- HEGFL
- HER1
- KIP1
- KIS
- KIST
- MAPK1
- MAPK3
- PKB
- PKBG
- PRAD1
- PRKM1
- PRKM2
- PRKM3
- PTK2
- RAC
- SDGF
- SRF
- TGFA
- UHMK1
- XPO1
- p27
|
Homo sapiens (human)
|
|
PI3K/AKT Signaling
|
|
|
- AKT1
- AKT2
- AKT3
- AREG
- AREGB
- ARHG
- BCAP
- BDNF
- BTC
- C20orf97
- C9orf26
- CD135
- CD19
- CD28
- CD28LG
- CD28LG1
- CD28LG2
- CD80
- CD86
- CTMP
- DER4
- DTR
- DTS
- EGF
- EGFR
- EPGN
- ERBB
- ERBB1
- ERBB2
- EREG
- ESR
- ESR1
- ESR2
- ESTRB
- FGF1
- FGF10
- FGF16
- FGF18
- FGF19
- FGF2
- FGF20
- FGF22
- FGF23
- FGF3
- FGF4
- FGF6
- FGF7
- FGF9
- FGFA
- FGFB
- FGFR4
- FLK2
- FLT3
- FLT3LG
- FRAP
- FRAP1
- FRAP2
- FRS2
- FYN
- GAB1
- GAB2
- GBL
- GGF
- GRB1
- HBEGF
- HEGFL
- HER1
- HER2
- HGF
- HGL
- HPTA
- HRGA
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- IL1F11
- IL1RL1
- IL33
- INT2
- IRAK
- IRAK1
- IRAK4
- IRS1
- IRS2
- JTK2
- KGF
- KIAA0571
- KIAA1999
- KIT
- KLB
- KS3
- LAB7
- LCK
- LST8
- M
- MAPKAP1
- MET
- MIP1
- MLN19
- MLST8
- MTOR
- MYD88
- N
- NDF
- NEU
- NFHEV
- NGL
- NIPK
- NR3A1
- NR3A2
- NRG1
- NRG2
- NRG3
- NRG4
- NTAK
- NTF3
- NTF4
- NTF5
- NTRK2
- NTRK3
- PDGF2
- PDGFB
- PDGFR
- PDGFR1
- PDGFR2
- PDGFRA
- PDGFRB
- PDK1
- PDPK1
- PIK3AP1
- PIK3C1
- PIK3CA
- PIK3CB
- PIK3CD
- PIK3R1
- PIK3R2
- PIK3R3
- PKB
- PKBG
- PROTOR1
- PRR5
- PTP2C
- PTPN11
- RAC
- RAC1
- RAC2
- RAFT1
- RAPT1
- RHEPDGFRA
- RHOG
- RICTOR
- RNF85
- SCFR
- SDGF
- SGK
- SGK1
- SHPTP2
- SIN1
- SIS
- SKIP3
- SMDF
- SRC
- SRC1
- ST2
- STK1
- STRN
- T1
- TC25
- TCRIM
- TGFA
- THEM4
- TKF
- TRAF6
- TRAT1
- TRB3
- TRIB3
- TRKB
- TRKC
- VAV
- VAV1
|
Homo sapiens (human)
|
|
RAB GEFs exchange GTP for GDP on RABs
|
|
|
- AKT1
- AKT2
- AKT3
- ALS2
- ALS2CL
- ALS2CR6
- ANKRD27
- BET3
- BET5
- C1orf218
- C4orf41
- C5orf44
- C7orf28A
- C7orf28B
- C9orf55
- C9orf55B
- CCZ1
- CCZ1B
- CHM
- CHML
- CIP150
- CMT4B2
- DENND1A
- DENND1B
- DENND1C
- DENND2A
- DENND2B
- DENND2C
- DENND2D
- DENND3
- DENND4A
- DENND4B
- DENND4C
- DENND5A
- DENND5B
- DENND6A
- DENND6B
- EHOC1
- FAM116A
- FAM116B
- FAM31A
- FAM31B
- FAM31C
- GAPEX5
- GAPVD1
- GDI1
- GDI2
- GDIL
- HPS
- HPS1
- HPS4
- HSRG1
- HTS1
- IRLB
- KIAA0066
- KIAA0118
- KIAA0258
- KIAA0476
- KIAA0722
- KIAA0839
- KIAA0870
- KIAA0872
- KIAA1012
- KIAA1091
- KIAA1277
- KIAA1432
- KIAA1521
- KIAA1563
- KIAA1608
- KIAA1667
- KIAA1766
- KIAA1882
- MEL
- MON1A
- MON1B
- MTMR13
- MTMR5
- MUM2
- MYCPBP
- NIBP
- OPHN2
- PKB
- PKBG
- RAB1
- RAB10
- RAB12
- RAB13
- RAB14
- RAB18
- RAB1A
- RAB1B
- RAB1C
- RAB21
- RAB22B
- RAB27
- RAB27A
- RAB27B
- RAB31
- RAB32
- RAB35
- RAB38
- RAB39
- RAB39A
- RAB39B
- RAB3A
- RAB3GAP
- RAB3GAP1
- RAB3GAP2
- RAB3IL1
- RAB3IP
- RAB5
- RAB5A
- RAB5B
- RAB5C
- RAB6
- RAB6A
- RAB6B
- RAB6IP1
- RAB7
- RAB7A
- RAB7B
- RAB8
- RAB8A
- RAB8B
- RAB9
- RAB9A
- RAB9B
- RAB9L
- RABEX5
- RABGDIA
- RABGDIB
- RABGEF1
- RABIN8
- RABL
- RAC
- RAP6
- RASSF4
- RAY
- REP1
- REP2
- RGP1
- RIC1
- RIN1
- RIN2
- RIN3
- RINL
- SAND1
- SAND2
- SBDN
- SBF1
- SBF2
- SEDL
- ST5
- TCD
- TMEM1
- TRAMM
- TRAPPC1
- TRAPPC10
- TRAPPC11
- TRAPPC12
- TRAPPC13
- TRAPPC2
- TRAPPC2L
- TRAPPC3
- TRAPPC4
- TRAPPC5
- TRAPPC6A
- TRAPPC6B
- TRAPPC8
- TRAPPC9
- TTC15
- ULK1
- XAP4
- YWHAE
|
Homo sapiens (human)
|
|
MTOR signalling
|
|
|
- AKT1
- AKT1S1
- C11orf59
- C7orf59
- FRAP
- FRAP1
- FRAP2
- GBL
- HBXIP
- KIAA1303
- LAMTOR1
- LAMTOR2
- LAMTOR3
- LAMTOR4
- LAMTOR5
- LST8
- MAP2K1IP1
- MAPBPIP
- MAPKSP1
- MLST8
- MTOR
- PDRO
- PKB
- PRAS40
- RAC
- RAFT1
- RAPT1
- RAPTOR
- RHEB
- RHEB2
- ROBLD3
- RPTOR
- RRAGA
- RRAGB
- RRAGC
- RRAGD
- SLC38A9
- URLC11
- XIP
- YWHAB
|
Homo sapiens (human)
|
|
AKT phosphorylates targets in the cytosol
|
|
|
- AKT1
- AKT1S1
- AKT2
- AKT3
- BAD
- BBC6
- BCL2L8
- CAP20
- CASP9
- CDKN1
- CDKN1A
- CDKN1B
- CHUK
- CIP1
- GSK3A
- GSK3B
- IKKA
- KIP1
- MCH6
- MDA6
- MDM2
- MKRN1
- PIC1
- PKB
- PKBG
- PRAS40
- RAC
- RNF61
- SDI1
- TCF16
- TSC2
- TSC4
- WAF1
- p27
|
Homo sapiens (human)
|
|
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
|
|
|
- AKR1C3
- C1orf93
- C9orf15
- CBR
- CBR1
- COX1
- COX2
- CRN
- CYP12
- CYP5
- CYP5A1
- CYP8
- CYP8A1
- CYP8B1
- DDH1
- FAM213B
- GSTS
- HPGD
- HPGDS
- HSD17B5
- KIAA0119
- MGST1L1
- MPGES1
- P23
- PDS
- PGDH1
- PGDS
- PGES
- PGES2
- PGFS
- PIG12
- PRXL2B
- PTGDS
- PTGDS2
- PTGES
- PTGES2
- PTGES3
- PTGIS
- PTGR2
- PTGS1
- PTGS2
- SDR21C1
- SDR36C1
- TBXAS1
- TEBP
- TXAS
- ZADH1
|
Homo sapiens (human)
|
|
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
|
|
|
- AKR1C1
- AKR1C2
- AKR1C3
- AKR1C4
- AKR1D1
- BAR
- BHLHE74
- BHLHE75
- CHDR
- CYP12
- CYP27
- CYP27A1
- CYP7
- CYP7A1
- CYP7B1
- CYP8B1
- DDH
- DDH1
- DDH2
- FXR
- HRR1
- HSD17B5
- HSD3B7
- KIAA0119
- NCOA1
- NCOA2
- NR1H4
- NR2B1
- PGFS
- RIP14
- RXRA
- SRC1
- SRC2
- SRD5B1
- TIF2
|
Homo sapiens (human)
|
|
Estrogen biosynthesis
|
|
|
- AKR1B15
- ARO1
- CYAR
- CYP19
- CYP19A1
- DHRS10
- DHRS8
- E17KSR
- EDH17B1
- EDH17B2
- EDHB17
- HSD17B1
- HSD17B11
- HSD17B14
- HSD17B2
- PAN1B
- SDR16C2
- SDR28C1
- SDR3
- SDR47C1
- SDR9C2
|
Homo sapiens (human)
|
|
Fructose biosynthesis
|
|
|
|
Homo sapiens (human)
|
|
Glutathione conjugation
|
|
|
- AKR1A1
- ALDR1
- ALR
- ESD
- FAEES3
- GST1
- GST12
- GST2
- GST3
- GST4
- GST5
- GSTA1
- GSTA2
- GSTA3
- GSTA4
- GSTA5
- GSTK1
- GSTM1
- GSTM2
- GSTM3
- GSTM4
- GSTM5
- GSTO1
- GSTO2
- GSTP1
- GSTS
- GSTT1
- GSTT2
- GSTT2B
- GSTTLP28
- GSTZ1
- HPGDS
- MAAI
- MGST
- MGST1
- MGST2
- MGST3
- PGDS
- PTGDS2
|
Homo sapiens (human)
|
|
Formation of xylulose-5-phosphate
|
|
|
- AKR1A1
- ALDR1
- ALR
- CRY
- CRYL1
- DCXR
- SDR20C1
- SORD
- XYLB
|
Homo sapiens (human)
|
|
ROBO receptors bind AKAP5
|
|
|
- AKAP5
- AKAP79
- CALNA2
- CALNB
- CNA2
- KIAA1568
- PKACA
- PKCA
- PKR2
- PPP3CB
- PRKACA
- PRKACB
- PRKACG
- PRKAR2
- PRKAR2A
- PRKCA
- ROBO2
|
Homo sapiens (human)
|
|
Trafficking of AMPA receptors
|
|
|
- AKAP5
- AKAP79
- CACNG2
- CACNG3
- CACNG4
- CACNG6
- CACNG8
- CAM2
- CAMK
- CAMK-II
- CAMK2
- CAMK2A
- CAMK2B
- CAMK2D
- CAMK2G
- CAMKA
- CAMKB
- CAMKD
- CAMKG
- DLG1
- DLG4
- EPB41L1
- GLUA1
- GLUH1
- GLUR1
- GLUR3
- GLUR4
- GLURC
- GRIA1
- GRIA3
- GRIA4
- GluA3
- GluA4
- KIAA0338
- KIAA0389
- KIAA0968
- MDM2
- MYO6
- PSD95
|
Homo sapiens (human)
|
|
Phase 3 - rapid repolarisation
|
|
|
- AKAP350
- AKAP450
- AKAP9
- AMMECR2
- ERG
- ERG1
- HERG
- KCNA5
- KCNA8
- KCNA9
- KCNE1
- KCNE1L
- KCNE2
- KCNE3
- KCNE4
- KCNE5
- KCNH2
- KCNQ1
- KIAA0803
- KVLQT1
|
Homo sapiens (human)
|
|
Phase 2 - plateau phase
|
|
|
- AKAP350
- AKAP450
- AKAP9
- AMMECR2
- CACH2
- CACN2
- CACNA1C
- CACNA2D2
- CACNB1
- CACNB2
- CACNG4
- CACNG6
- CACNG7
- CACNG8
- CACNL1A1
- CACNLB1
- CACNLB2
- CCHL1A1
- KCNA8
- KCNA9
- KCNE1
- KCNE1L
- KCNE2
- KCNE3
- KCNE4
- KCNE5
- KCNQ1
- KIAA0558
- KIAA0803
- KVLQT1
- MYSB
|
Homo sapiens (human)
|
|