GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **2001 - 2025** of **2090** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	Eukaryotic initiation factor 4A-I Eukaryotic initiation factor 4A-II Eukaryotic translation initiation factor 4 gamma 1 Eukaryotic translation initiation factor 4B Eukaryotic translation initiation factor 4E-binding protein 1 Eukaryotic translation initiation factor 4E Eukaryotic translation initiation factor 4H	P06730 P23588 P60842 Q04637 Q13541 Q14240 Q15056	DDX2A DDX2B EIF4A EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4EL1 EIF4F EIF4G EIF4G1 EIF4GI EIF4H KIAA0038 WBSCR1 WSCR1
Activation of the TFAP2 (AP-2) family of transcription factors	CREB-binding protein Cbp/p300-interacting transactivator 1 Cbp/p300-interacting transactivator 2 Cbp/p300-interacting transactivator 4 Histone acetyltransferase p300 Transcription factor AP-2 gamma Transcription factor AP-2-alpha Transcription factor AP-2-beta Transcription factor AP-2-delta Transcription factor AP-2-epsilon WW domain-containing oxidoreductase YEATS domain-containing protein 4	O95619 P05549 Q09472 Q6VUC0 Q7Z6R9 Q92481 Q92754 Q92793 Q96RK1 Q99966 Q99967 Q9NZC7	AP2TF CBP CITED1 CITED2 CITED4 CREBBP EP300 FOR GAS41 MRG1 MRG2 MSG1 P300 SDR41C1 TFAP2 TFAP2A TFAP2B TFAP2BL1 TFAP2C TFAP2D TFAP2E WOX1 WWOX YEATS4
Activation of the AP-1 family of transcription factors	Cyclic AMP-dependent transcription factor ATF-2 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Protein c-Fos Transcription factor Jun	P01100 P05412 P15336 P27361 P28482 P45983 P45984 P53779 Q15759 Q16539	ATF2 CREB2 CREBP1 CSBP CSBP1 CSBP2 CSPB1 ERK1 ERK2 FOS G0S7 JNK1 JNK2 JNK3 JNK3A JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MXI2 PRKM1 PRKM10 PRKM11 PRKM2 PRKM3 PRKM8 PRKM9 SAPK1 SAPK1A SAPK1B SAPK1C SAPK2 SAPK2A SAPK2B
Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a)	Chromobox protein homolog 3 Chromodomain-helicase-DNA-binding protein 3 Chromodomain-helicase-DNA-binding protein 4 DNA excision repair protein ERCC-6 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone deacetylase 1 Histone deacetylase 2 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EHMT2 Metastasis-associated protein MTA1 Metastasis-associated protein MTA2 Metastasis-associated protein MTA3 Methyl-CpG-binding domain protein 3 Transcription termination factor 1 Transcriptional repressor p66-alpha Transcriptional repressor p66-beta	O60814 O94776 O95983 P04908 P06899 P0C5Y9 P16104 P20671 P23527 P33778 P57053 P58876 P62805 P62807 P68431 P84243 Q03468 Q09028 Q12873 Q13185 Q13330 Q13547 Q14839 Q15361 Q16576 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q86YP4 Q8N257 Q8WXI9 Q92769 Q93077 Q93079 Q96A08 Q96KQ7 Q99877 Q99878 Q99879 Q99880 Q9BTC8 Q9BTM1	BAT8 C6orf30 CBX3 CHD3 CHD4 CSB EHMT2 ERCC6 G9A GATAD2A GATAD2B H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HDAC1 HDAC2 HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 KIAA1150 KIAA1266 KMT1C MBD3 MTA1 MTA1L1 MTA2 MTA3 NG36 PID RBAP46 RBAP48 RBBP4 RBBP7 RPD3L1 TSH2B TTF1
Activation of gene expression by SREBF (SREBP)	3'-5' exoribonuclease HELZ2 7-dehydrocholesterol reductase Acetyl-CoA carboxylase 1 Acetyl-CoA carboxylase 2 CREB-binding protein Chromodomain-helicase-DNA-binding protein 9 Delta(14)-sterol reductase TM7SF2 Diphosphomevalonate decarboxylase F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 Farnesyl pyrophosphate synthase Fatty acid synthase Geranylgeranyl pyrophosphate synthase Glycerol-3-phosphate acyltransferase 1, mitochondrial Histone-arginine methyltransferase CARM1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic Isopentenyl-diphosphate Delta-isomerase 1 Lanosterol 14-alpha demethylase Lanosterol synthase Lathosterol oxidase Mediator of RNA polymerase II transcription subunit 1 Metal regulatory transcription factor 1 Mevalonate kinase Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 6 Nuclear transcription factor Y subunit alpha Nuclear transcription factor Y subunit beta Nuclear transcription factor Y subunit gamma Peroxisome proliferator-activated receptor alpha Phosphomevalonate kinase Retinoic acid receptor RXR-alpha SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Squalene monooxygenase Squalene synthase Stearoyl-CoA desaturase Sterol regulatory element-binding protein 2 Transcription factor Sp1 Trimethylguanosine synthase Very long chain fatty acid elongase 6	O00763 O00767 O60907 O75845 O76062 O95749 P08047 P14324 P19793 P23511 P25208 P37268 P48449 P49327 P53602 Q01581 Q03426 Q07869 Q12772 Q13085 Q13907 Q13952 Q14534 Q14686 Q14872 Q15126 Q15596 Q15648 Q15788 Q16850 Q3L8U1 Q6STE5 Q86X55 Q92793 Q96RS0 Q9BYK8 Q9BZK7 Q9H5J4 Q9HCL2 Q9UBM7	ACAC ACACA ACACB ACC1 ACC2 ACCA ACCB AIB3 ANG1 ARC205 BAF60C BHLHD2 BHLHE74 BHLHE75 CARM1 CBP CHD9 CREBBP CRSP1 CRSP200 CYP51 CYP51A1 D7SR DHCR7 DRIP205 DRIP230 ELOVL6 ERG1 FACE FADS5 FAS FASN FDFT1 FDPS FPS GGPS1 GPAM GPAT1 HAP3 HCA137 HELZ2 HMGCS HMGCS1 IDI1 IRA1 KIAA0181 KIAA0308 KIAA1293 KIAA1560 KIAA1769 KISH2 LCE LSS MED1 MPD MTF1 MVD MVK NCOA1 NCOA2 NCOA6 NCOA6IP NFYA NFYB NFYC NR1C1 NR2B1 OSC PBP PIMT PMKI PMVK PPAR PPARA PPARBP PPARGBP PRIC285 PRIC320 PRMT4 RAP250 RB18A RXRA SC5D SC5DL SCD SCD1 SCDOS SMARCD3 SP1 SQLE SRC1 SRC2 SREBF2 SREBP2 TBL1 TBL1X TBL1XR1 TBLR1 TGS1 TIF2 TM7SF2 TRAP220 TRBP TRIP2 TSFP1
Activation of caspases through apoptosome-mediated cleavage	Apoptotic protease-activating factor 1 Caspase-3 Caspase-7 Caspase-9 Cytochrome c E3 ubiquitin-protein ligase XIAP	O14727 P42574 P55210 P55211 P98170 P99999	APAF1 API3 BIRC4 CASP3 CASP7 CASP9 CPP32 CYC CYCS IAP3 KIAA0413 MCH3 MCH6 XIAP
Activation of anterior HOX genes in hindbrain development during early embryogenesis	CCR4-NOT transcription complex subunit 6 CCR4-NOT transcription complex subunit 9 CREB-binding protein DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 E3 SUMO-protein ligase EGR2 E3 SUMO-protein ligase PIAS2 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone acetyltransferase p300 Histone deacetylase 3 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase 2C Histone-lysine N-methyltransferase 2D Histone-lysine N-methyltransferase EZH2 Homeobox protein Hox-A1 Homeobox protein Hox-A2 Homeobox protein Hox-A3 Homeobox protein Hox-A4 Homeobox protein Hox-B1 Homeobox protein Hox-B2 Homeobox protein Hox-B3 Homeobox protein Hox-B4 Homeobox protein Hox-C4 Homeobox protein Hox-D1 Homeobox protein Hox-D3 Homeobox protein Hox-D4 Homeobox protein Meis1 Homeobox protein PKNOX1 LIM domain-containing protein ajuba Lysine-specific demethylase 6A Nuclear receptor coactivator 3 Nuclear receptor coactivator 6 Nuclear receptor corepressor 1 PAX-interacting protein 1 PAXIP1-associated glutamate-rich protein 1 Paired box protein Pax-6 Polycomb group RING finger protein 2 Polycomb protein EED Polycomb protein SUZ12 Pre-B-cell leukemia transcription factor 1 Protein dpy-30 homolog Retinoblastoma-binding protein 5 Retinoic acid receptor RXR-alpha Retinoic acid receptor alpha Retinoic acid receptor beta Retinoic acid receptor gamma Set1/Ash2 histone methyltransferase complex subunit ASH2 Transcription factor Jun Transcription factor MafB Transcriptional repressor CTCF Transcriptional repressor protein YY1 WD repeat-containing protein 5 Zinc finger protein 335	O00470 O14686 O15379 O15514 O15550 O43364 O43365 O60814 O75376 O75530 O75928 P04908 P05412 P06899 P09016 P09017 P0C5Y9 P10276 P10826 P11161 P13631 P14651 P14652 P14653 P16104 P17483 P19387 P19388 P19793 P20671 P23527 P24928 P25490 P26367 P30876 P31249 P33778 P35227 P36954 P40424 P49639 P49711 P52434 P52435 P53803 P55347 P57053 P58876 P61218 P61964 P62487 P62805 P62807 P62875 P68431 P84243 Q00056 Q09028 Q09472 Q14686 Q15022 Q15291 Q15910 Q16576 Q16777 Q16778 Q6FI13 Q6ZW49 Q71DI3 Q71UI9 Q8N257 Q8NEZ4 Q92600 Q92793 Q93077 Q93079 Q96A08 Q96IF1 Q99877 Q99878 Q99879 Q99880 Q9BTK6 Q9BTM1 Q9C005 Q9GZZ0 Q9H4Z2 Q9UBL3 Q9ULM6 Q9Y5Q3 Q9Y6Q9	AIB1 AIB3 AJUBA ALR AN2 ASH2L ASH2L1 BHLHE42 BIG3 C16orf53 CBP CCR4 CCR4a CHET9 CNOT6 CNOT9 CREBBP CTCF DPY30 EED EGR2 EP300 EZH2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HALR HAP HDAC3 HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 HOX1D HOX1E HOX1F HOX1K HOX2F HOX2G HOX2H HOX2I HOX3E HOX4 HOX4A HOX4B HOX4G HOXA1 HOXA2 HOXA3 HOXA4 HOXB1 HOXB2 HOXB3 HOXB4 HOXC4 HOXD1 HOXD3 HOXD4 INO80S JJAZ1 JUB JUN KDM6A KIAA0160 KIAA0181 KIAA1047 KIAA1194 KIAA1506 KMT2C KMT2D KMT6 KRML KROX20 MAFB MEIS1 MEL18 MLL2 MLL3 MLL4 NCOA3 NCOA6 NCOR1 NR1B1 NR1B2 NR1B3 NR2B1 P300 PA1 PAGR1 PAX6 PAXIP1 PAXIP1L PBX1 PCGF2 PIAS2 PIASX PKNOX1 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF PREP1 PRL PTIP RAC3 RAP250 RARA RARB RARG RBAP46 RBAP48 RBBP4 RBBP5 RBBP7 RBQ3 RCD1 RNF110 RPB7 RQCD1 RXRA SUZ12 TRAM1 TRBP TSH2B UTX WDR5 YY1 ZNF144 ZNF335
Activation of SMO	Beta-adrenergic receptor kinase 1 Beta-arrestin-1 Beta-arrestin-2 Brother of CDO Casein kinase I isoform alpha Cell adhesion molecule-related/down-regulated by oncogenes Desert hedgehog protein Dynein regulatory complex subunit 4 EF-hand calcium-binding domain-containing protein 7 EvC complex member EVC Growth arrest-specific protein 1 IQ domain-containing protein E Indian hedgehog protein Kinesin-like protein KIF3A Limbin Protein patched homolog 1 Protein smoothened Sonic hedgehog protein	A8K855 O43323 O95995 P25098 P32121 P48729 P49407 P54826 P57679 Q13635 Q14623 Q15465 Q4KMG0 Q6IPM2 Q86UK5 Q99835 Q9BWV1 Q9Y496	ADRBK1 ARB2 ARR1 ARR2 ARRB1 ARRB2 BARK BARK1 BOC CDO CDON CSNK1A1 DHH DRC4 EFCAB7 EVC EVC2 GAS1 GAS11 GAS8 GRK2 IHH IQCE KIAA1023 KIAA1799 KIF3 KIF3A LBN PTCH PTCH1 SHH SMO SMOH
Activation of RAS in B cells	GTPase HRas GTPase NRas RAS guanyl-releasing protein 1 Ras guanyl-releasing protein 3	O95267 P01111 P01112 Q8IV61	GRP3 HRAS HRAS1 KIAA0846 NRAS RASGRP RASGRP1 RASGRP3
Activation of RAC1 downstream of NMDARs	ARF GTPase-activating protein GIT1 Calcium/calmodulin-dependent protein kinase kinase 1 Calcium/calmodulin-dependent protein kinase kinase 2 Calcium/calmodulin-dependent protein kinase type 1 Calmodulin-1 Ras-related C3 botulinum toxin substrate 1	P0DP23 P63000 Q14012 Q8N5S9 Q96RR4 Q9Y2X7	CALM CALM1 CAM CAM1 CAMK1 CAMKK1 CAMKK2 CAMKKA CAMKKB GIT1 KIAA0787 RAC1 TC25
Activation of RAC1	Cytoplasmic protein NCK2 Ras-related C3 botulinum toxin substrate 1 Roundabout homolog 1 SH2/SH3 adapter protein NCK1 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase PAK 4 Serine/threonine-protein kinase PAK 5 Serine/threonine-protein kinase PAK 6 Slit homolog 2 protein Son of sevenless homolog 1 Son of sevenless homolog 2	O43639 O75914 O94813 O96013 P16333 P63000 Q07889 Q07890 Q13153 Q13177 Q9NQU5 Q9P286 Q9Y6N7	DUTT1 GRB4 KIAA1142 KIAA1264 NCK NCK1 NCK2 OPHN3 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PAK7 RAC1 ROBO1 SLIL3 SLIT2 SOS1 SOS2 TC25
Activation of PUMA and translocation to mitochondria	Apoptosis-stimulating of p53 protein 1 Apoptosis-stimulating of p53 protein 2 Bcl-2-binding component 3, isoforms 1/2 Cellular tumor antigen p53 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Tumor protein 63 Tumor protein p73	O15350 P04637 Q01094 Q13625 Q14186 Q14188 Q96KQ4 Q9BXH1 Q9H3D4	ASPP1 ASPP2 BBC3 BBP DP1 DP2 E2F1 KET KIAA0771 P53 P63 P73 P73H P73L PPP1R13B PUMA RBBP3 TFDP1 TFDP2 TP53 TP53BP2 TP63 TP73 TP73L
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 14 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	O43741 P53778 P54619 P54646 Q15759 Q16539 Q9UBK2 Q9UGI9 Q9UGJ0 Q9Y478	AMPK AMPK2 AMPKG3 CSBP CSBP1 CSBP2 CSPB1 ERK6 LEM6 MAPK11 MAPK12 MAPK14 MXI2 PGC1 PGC1A PPARGC1 PPARGC1A PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRKM11 SAPK2 SAPK2A SAPK2B SAPK3
Activation of PKB	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 RAC-beta serine/threonine-protein kinase Tribbles homolog 3	O15530 P31751 Q5T1C6 Q96RU7	AKT2 C20orf97 CTMP NIPK PDK1 PDPK1 SKIP3 THEM4 TRB3 TRIB3
Activation of Na-permeable kainate receptors	Glutamate receptor ionotropic, kainate 1 Glutamate receptor ionotropic, kainate 2	P39086 Q13002	GLUR5 GLUR6 GRIK1 GRIK2
Activation of NOXA and translocation to mitochondria	Cellular tumor antigen p53 Phorbol-12-myristate-13-acetate-induced protein 1 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1	P04637 Q01094 Q13794 Q14186 Q14188	DP1 DP2 E2F1 NOXA P53 PMAIP1 RBBP3 TFDP1 TFDP2 TP53
Activation of NIMA Kinases NEK9, NEK6, NEK7	Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 G2/mitotic-specific cyclin-B2 Serine/threonine-protein kinase Nek6 Serine/threonine-protein kinase Nek7 Serine/threonine-protein kinase Nek9 Serine/threonine-protein kinase PLK1	O95067 P06493 P14635 P53350 Q8TD19 Q8TDX7 Q9HC98	CCNB CCNB1 CCNB2 CDC2 CDC28A CDK1 CDKN1 KIAA1995 NEK6 NEK7 NEK8 NEK9 NERCC P34CDC2 PLK PLK1
Activation of NF-kappaB in B cells	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 B-cell lymphoma/leukemia 10 Caspase recruitment domain-containing protein 11 Cullin-1 F-box/WD repeat-containing protein 11 F-box/WD repeat-containing protein 1A Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Mitogen-activated protein kinase kinase kinase 7 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 NF-kappa-B essential modulator NF-kappa-B inhibitor alpha NF-kappa-B inhibitor beta NF-kappa-B inhibitor epsilon Nuclear factor NF-kappa-B p105 subunit Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Protein kinase C beta type Proto-oncogene c-Rel S-phase kinase-associated protein 1 Transcription factor p65 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5LHX3 O00221 O00231 O00232 O00233 O00487 O14818 O14920 O15111 O43242 O43318 O75832 O95999 P05771 P0CG47 P0CG48 P17980 P19838 P20618 P25786 P25787 P25788 P25789 P25963 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P55036 P60896 P60900 P61289 P62191 P62195 P62333 P62979 P62987 P63208 Q04206 Q04864 Q06323 Q13200 Q13616 Q14997 Q15008 Q15653 Q16401 Q8TAA3 Q92530 Q99436 Q99460 Q9BXL7 Q9UDY8 Q9UKB1 Q9UL46 Q9UNM6 Q9Y297 Q9Y6K9	BCL10 BTRC BTRCP BTRCP2 C7orf76 CARD11 CARMA1 CHUK CIPER CLAP CUL1 DSS1 EMC19 FBW1A FBW1B FBXW11 FBXW1A FBXW1B FIP3 HC2 HC3 HC8 HC9 HSPC IFI5111 IKBA IKBB IKBE IKBKB IKBKG IKKA IKKB KIAA0072 KIAA0077 KIAA0107 KIAA0696 LMP10 LMP2 LMP7 LMPX LMPY MAD3 MALT1 MAP3K7 MB1 MCB1 MECL1 MIP224 MLT MOV34L MSS1 NEMO NFKB1 NFKB3 NFKBI NFKBIA NFKBIB NFKBIE NU OCP2 PFAAP4 PKCB POH1 PRKCB PRKCB1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 REL RELA RING10 RING12 RPS27A SEM1 SHFDG1 SHFM1 SKP1 SKP1A SUG1 SUG2 TAK1 TBP1 TBP7 TCEB1L TCF16 TRAP2 TRIP9 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 X Y Y2 Z
Activation of Matrix Metalloproteinases	72 kDa type IV collagenase Cathepsin G Cathepsin K Cathepsin L2 Chymase Chymotrypsinogen B2 Chymotrypsinogen B Collagen alpha-1(XVIII) chain Collagenase 3 Furin Interstitial collagenase Kallikrein-2 Matrilysin Matrix metalloproteinase-14 Matrix metalloproteinase-15 Matrix metalloproteinase-16 Matrix metalloproteinase-17 Matrix metalloproteinase-24 Matrix metalloproteinase-25 Matrix metalloproteinase-9 Metalloproteinase inhibitor 1 Metalloproteinase inhibitor 2 Neutrophil collagenase Neutrophil elastase Plasma kallikrein Plasminogen Serine protease 1 Stromelysin-1 Stromelysin-2 Stromelysin-3 Testican-3 Trypsin-2 Tryptase alpha/beta-1	O60911 P00747 P01033 P03952 P03956 P07477 P07478 P08246 P08253 P08254 P08311 P09237 P09238 P09958 P14780 P16035 P17538 P20151 P22894 P23946 P24347 P39060 P43235 P45452 P50281 P51511 P51512 Q15661 Q6GPI1 Q9BQ16 Q9NPA2 Q9ULZ9 Q9Y5R2	C8orf57 CATL2 CLG CLG1 CLG4A CLG4B CLGI CMA1 COL18A1 CTRB CTRB1 CTRB2 CTSG CTSK CTSL2 CTSO CTSO2 CTSU CTSV CYH CYM ELA2 ELANE FUR FURIN KLK2 KLK3 KLKB1 MMP1 MMP10 MMP11 MMP13 MMP14 MMP15 MMP16 MMP17 MMP2 MMP20 MMP24 MMP25 MMP3 MMP7 MMP8 MMP9 MMPL1 MMPX2 MPSL1 MT4MMP MT5MMP MT6MMP PACE PCSK3 PLG PRSS1 PRSS2 PUMP1 SPOCK3 STMY1 STMY2 STMY3 TICN3 TIMP TIMP1 TIMP2 TPS1 TPS2 TPSAB1 TPSB1 TRP1 TRY1 TRY2 TRYP1 TRYP2
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	Inhibitor of nuclear factor kappa-B kinase subunit epsilon Interferon regulatory factor 3 Interferon regulatory factor 7 Lymphocyte antigen 96 Monocyte differentiation antigen CD14 Optineurin Polyubiquitin-B Polyubiquitin-C Serine/threonine-protein kinase TBK1 TIR domain-containing adapter molecule 1 TIR domain-containing adapter molecule 2 TNF receptor-associated factor 3 TRAF family member-associated NF-kappa-B activator Toll-like receptor 4 Tyrosine-protein phosphatase non-receptor type 11 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00206 P08571 P0CG47 P0CG48 P62979 P62987 Q06124 Q13114 Q14164 Q14653 Q86XR7 Q8IUC6 Q92844 Q92985 Q96CV9 Q9UHD2 Q9Y6Y9	CAP-1 CD14 CRAF1 ESOP1 FIP2 GLC1E HIP7 HYPL IKBKE IKKE IKKI IRF3 IRF7 ITRAF KIAA0151 LY96 MD2 NAK NRP OPTN PRVTIRB PTP2C PTPN11 RPS27A SHPTP2 TANK TBK1 TICAM1 TICAM2 TIRAP3 TIRP TLR4 TRAF2 TRAF3 TRAFAMN TRAM TRIF UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
Activation of G protein gated Potassium channels	ATP-sensitive inward rectifier potassium channel 10 ATP-sensitive inward rectifier potassium channel 12 ATP-sensitive inward rectifier potassium channel 15 G protein-activated inward rectifier potassium channel 1 G protein-activated inward rectifier potassium channel 2 G protein-activated inward rectifier potassium channel 3 G protein-activated inward rectifier potassium channel 4 Gamma-aminobutyric acid type B receptor subunit 1 Gamma-aminobutyric acid type B receptor subunit 2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Inward rectifier potassium channel 16 Inward rectifier potassium channel 2 Inward rectifier potassium channel 4	O14610 O14775 O60262 O75899 P16520 P48050 P48051 P48544 P48549 P50150 P50151 P59768 P61952 P62873 P62879 P63211 P63215 P63218 P63252 P78508 Q14500 Q92806 Q99712 Q9HAV0 Q9NPI9 Q9P2W3 Q9UBI6 Q9UBS5 Q9UK08	GABBR1 GABBR2 GIRK1 GIRK2 GIRK3 GIRK4 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 GPR51 GPRC3A GPRC3B IRK1 IRK2 IRK3 KATP2 KCNJ10 KCNJ12 KCNJ14 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ7 KCNJ9 KCNJN1
Activation of Ca-permeable Kainate Receptor	Calmodulin-1 Disks large homolog 1 Disks large homolog 3 Disks large homolog 4 Glutamate receptor ionotropic, kainate 1 Glutamate receptor ionotropic, kainate 2 Glutamate receptor ionotropic, kainate 3 Glutamate receptor ionotropic, kainate 4 Glutamate receptor ionotropic, kainate 5 Neurocalcin-delta	P0DP23 P39086 P61601 P78352 Q12959 Q13002 Q13003 Q16099 Q16478 Q92796	CALM CALM1 CAM CAM1 DLG1 DLG3 DLG4 GLUR5 GLUR6 GLUR7 GRIK GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 KIAA1232 NCALD PSD95
Activation of C3 and C5	Complement C2 Complement C3 Complement C4-A Complement C4-B Complement C5 Complement factor B	P00751 P01024 P01031 P06681 P0C0L4 P0C0L5	BF BFD C2 C3 C4A C4B C4B_2 C5 CFB CO4 CPAMD1 CPAMD2 CPAMD3 CPAMD4
Activation of BMF and translocation to mitochondria	Bcl-2-modifying factor Dynein light chain 2, cytoplasmic Mitogen-activated protein kinase 8	P45983 Q96FJ2 Q96LC9	BMF DLC2 DYNLL2 JNK1 MAPK8 PRKM8 SAPK1 SAPK1C
Activation of BIM and translocation to mitochondria	Bcl-2-like protein 11 Dynein light chain 1, cytoplasmic Mitogen-activated protein kinase 8	O43521 P45983 P63167	BCL2L11 BIM DLC1 DNCL1 DNCLC1 DYNLL1 HDLC1 JNK1 MAPK8 PRKM8 SAPK1 SAPK1C

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