GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **776 - 800** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Hedgehog 'on' state	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cilium assembly protein DZIP1 Cullin-3 Desert hedgehog protein E3 ubiquitin-protein ligase Itchy homolog E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase SMURF1 E3 ubiquitin-protein ligase SMURF2 EvC complex member EVC G-protein coupled receptor 161 Indian hedgehog protein Kinesin-like protein KIF7 Limbin Parafibromin Polyubiquitin-B Polyubiquitin-C Proteasomal ubiquitin receptor ADRM1 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Protein numb homolog Protein patched homolog 1 Protein smoothened Serine/threonine-protein kinase ULK3 Sonic hedgehog protein Speckle-type POZ protein-like Speckle-type POZ protein Suppressor of fused homolog Transcriptional activator GLI3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Zinc finger protein GLI1 Zinc finger protein GLI2	O00231 O00232 O00487 O14818 O43242 O43323 O43791 P08151 P0CG47 P0CG48 P10070 P10071 P17980 P20618 P25786 P25787 P25788 P25789 P28066 P28070 P28072 P28074 P35998 P43686 P48556 P49720 P49721 P49757 P51665 P57679 P60896 P60900 P62191 P62195 P62333 P62877 P62979 P62987 Q13200 Q13618 Q13635 Q14623 Q15008 Q15465 Q16186 Q2M1P5 Q6IQ16 Q6P1J9 Q6PHR2 Q86UK5 Q86YF9 Q8N6U8 Q96J02 Q99436 Q99460 Q99835 Q9HAU4 Q9HCE7 Q9UMX1 Q9UNM6	ADRM1 C14orf41 C1orf28 C7orf76 CDC73 CUL3 DHH DSS1 DZIP DZIP1 DZIP2 EVC EVC2 GLI GLI1 GLI2 GLI3 GP110 GPR161 HC2 HC3 HC8 HC9 HRPT2 HSPC IHH ITCH KIAA0107 KIAA0617 KIAA0996 KIAA1625 KIF7 LBN LMPX LMPY MB1 MIP224 MOV34L MSS1 NU NUMB PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTCH PTCH1 RBX1 RNF75 ROC1 RPS27A SEM1 SHFDG1 SHFM1 SHH SMO SMOH SMURF1 SMURF2 SPOP SPOPL SUFU SUG1 SUG2 TBP1 TBP7 THP TRAP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 ULK3 X Y Z	Homo sapiens (human)
Growth hormone receptor signaling	Chorionic somatomammotropin hormone 1 Cytokine-inducible SH2-containing protein Disintegrin and metalloproteinase domain-containing protein 17 Growth hormone receptor Growth hormone variant Insulin receptor substrate 1 Insulin receptor substrate 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Prolactin receptor Prolactin Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Somatotropin Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 2 Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 6	O14508 O14543 O15524 O60674 P01236 P01241 P01242 P07948 P0DML2 P10912 P16471 P18031 P27361 P28482 P29350 P35568 P40763 P42224 P42229 P51692 P78536 Q9NSE2 Q9Y4H2	ADAM17 APRF CIS2 CIS3 CISH CSH1 CSVP ERK1 ERK2 G18 GH1 GH2 GHR HCP IRS1 IRS2 JAK2 JTK8 LYN MAPK1 MAPK3 PRKM1 PRKM2 PRKM3 PRL PRLR PTP1B PTP1C PTPN1 PTPN6 SOCS1 SOCS2 SOCS3 SSI1 SSI2 SSI3 STAT1 STAT3 STAT5 STAT5A STAT5B STATI2 TACE TIP3	Homo sapiens (human)
NRAGE signals death through JNK	A-kinase anchor protein 13 Active breakpoint cluster region-related protein Bcl-2-like protein 11 Bcl2-associated agonist of cell death Beta-nerve growth factor Ephexin-1 FYVE, RhoGEF and PH domain-containing protein 1 FYVE, RhoGEF and PH domain-containing protein 2 FYVE, RhoGEF and PH domain-containing protein 3 FYVE, RhoGEF and PH domain-containing protein 4 Guanine nucleotide exchange factor DBS Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Guanine nucleotide-binding protein subunit alpha-13 Intersectin-1 Kalirin Melanoma-associated antigen D1 Mitogen-activated protein kinase 8 Neuroepithelial cell-transforming gene 1 protein Obscurin Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Pleckstrin homology domain-containing family G member 2 Pleckstrin homology domain-containing family G member 5 Protein AATF Protein ECT2 Proto-oncogene DBL Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Ras-specific guanine nucleotide-releasing factor 2 Rho guanine nucleotide exchange factor 10-like protein Rho guanine nucleotide exchange factor 10 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 12 Rho guanine nucleotide exchange factor 15 Rho guanine nucleotide exchange factor 16 Rho guanine nucleotide exchange factor 17 Rho guanine nucleotide exchange factor 18 Rho guanine nucleotide exchange factor 19 Rho guanine nucleotide exchange factor 1 Rho guanine nucleotide exchange factor 26 Rho guanine nucleotide exchange factor 2 Rho guanine nucleotide exchange factor 33 Rho guanine nucleotide exchange factor 35 Rho guanine nucleotide exchange factor 37 Rho guanine nucleotide exchange factor 38 Rho guanine nucleotide exchange factor 39 Rho guanine nucleotide exchange factor 3 Rho guanine nucleotide exchange factor 40 Rho guanine nucleotide exchange factor 4 Rho guanine nucleotide exchange factor 5 Rho guanine nucleotide exchange factor 6 Rho guanine nucleotide exchange factor 7 Rho guanine nucleotide exchange factor 9 Rho guanine nucleotide exchange factor TIAM1 Rho guanine nucleotide exchange factor TIAM2 Son of sevenless homolog 1 Son of sevenless homolog 2 Triple functional domain protein Tumor necrosis factor receptor superfamily member 16	A1IGU5 A5YM69 A8MVX0 O14827 O15013 O15068 O15085 O43307 O43521 O60229 O75962 O94827 O94989 P01138 P08138 P10911 P15498 P45983 P52735 P63000 P98174 Q07889 Q07890 Q12774 Q12802 Q12979 Q13009 Q14155 Q14344 Q15052 Q15811 Q5JSP0 Q5VST9 Q5VV41 Q6ZSZ5 Q7Z628 Q7Z6J4 Q8IVF5 Q8IW93 Q8N4T4 Q8N5V2 Q8TCU6 Q8TER5 Q92888 Q92934 Q92974 Q96DR7 Q96M96 Q96PE2 Q9H7P9 Q9H8V3 Q9HCE6 Q9NR80 Q9NR81 Q9NXL2 Q9NY61 Q9NZN5 Q9UKW4 Q9Y5V3	AATF ABR AKAP13 ARHDH9 ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF26 ARHGEF3 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF5L ARHGEF6 ARHGEF7 ARHGEF8 ARHGEF9 BAD BBC6 BCL2L11 BCL2L8 BIM BRX C9orf100 CHE1 COOL1 COOL2 DBL DED DUET DUO ECT2 EPHEXIN4 FGD1 FGD2 FGD3 FGD4 FGDY FRABP GNA13 GRF2 GRINCHGEF HAPIP HT31 ITSN ITSN1 JNK1 KALRN KIAA0006 KIAA0142 KIAA0294 KIAA0337 KIAA0362 KIAA0380 KIAA0382 KIAA0424 KIAA0521 KIAA0651 KIAA0720 KIAA0915 KIAA1112 KIAA1415 KIAA1556 KIAA1626 KIAA1639 KIAA2016 LARG LBC LFP40 MAGED1 MAPK8 MCF2 MCF2L NBR NET1 NGEF NGF NGFB NGFR NRAGE OBSCN OST P85SPR PAK3BP PIXA PIXB PLEKHG2 PLEKHG5 PREX1 PRKM8 RAC1 RASGRF2 SAPK1 SAPK1C SGEF SH3D1A SOLO SOS1 SOS2 STEF TC25 TEM4 TIAM1 TIAM2 TIM TNFRSF16 TRAD TRIO VAV VAV1 VAV2 VAV3 ZFYVE3 ZFYVE4 ZFYVE5 ZFYVE6	Homo sapiens (human)
Rap1 signalling	14-3-3 protein beta/alpha 14-3-3 protein zeta/delta RAF proto-oncogene serine/threonine-protein kinase RAS guanyl-releasing protein 1 RAS guanyl-releasing protein 2 Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 Rap1 GTPase-activating protein 1 Rap1 GTPase-activating protein 2 Ras-related protein Rap-1A Ras-related protein Rap-1b Signal-induced proliferation-associated protein 1 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	O95267 O95398 P04049 P17612 P22612 P22694 P31946 P47736 P61224 P62834 P63104 Q684P5 Q7LDG7 Q8WZA2 Q96FS4	CDC25L CGEF1 CGEF2 EPAC EPAC1 EPAC2 GARNL4 KIAA0474 KIAA1039 KREV1 MCG7 PKACA PRKACA PRKACB PRKACG RAF RAF1 RAP1A RAP1B RAP1GA1 RAP1GA2 RAP1GAP RAP1GAP2 RAPGEF3 RAPGEF4 RASGRP RASGRP1 RASGRP2 SIPA1 SPA1 YWHAB YWHAZ	Homo sapiens (human)
Defective CP causes aceruloplasminemia (ACERULOP)	Ceruloplasmin Ferroportin	P00450 Q9NP59	CP FPN FPN1 IREG1 SLC11A3 SLC40A1	Homo sapiens (human)
Mitochondrial protein degradation	2-oxoglutarate dehydrogenase complex component E1 3-hydroxyacyl-CoA dehydrogenase type-2 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial 5-aminolevulinate synthase, non-specific, mitochondrial 60 kDa heat shock protein, mitochondrial ADP/ATP translocase 2 ADP/ATP translocase 3 ATP synthase subunit O, mitochondrial ATP synthase subunit a ATP synthase subunit alpha, mitochondrial ATP synthase subunit beta, mitochondrial ATP synthase subunit d, mitochondrial ATP synthase subunit g, mitochondrial ATP synthase subunit gamma, mitochondrial ATP synthase-coupling factor 6, mitochondrial ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial ATP-dependent Clp protease proteolytic subunit, mitochondrial ATP-dependent zinc metalloprotease YME1L1 Acetyl-CoA acetyltransferase, mitochondrial Aconitate hydratase, mitochondrial Acyl-coenzyme A thioesterase 2, mitochondrial Aldehyde dehydrogenase X, mitochondrial Aldehyde dehydrogenase, mitochondrial Arginase-2, mitochondrial Calcium uptake protein 2, mitochondrial Citrate synthase, mitochondrial Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 Cytochrome b-c1 complex subunit 2, mitochondrial Cytochrome b-c1 complex subunit 8 Cytochrome c oxidase subunit 1 Cytochrome c oxidase subunit 2 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase subunit 5B, mitochondrial D-beta-hydroxybutyrate dehydrogenase, mitochondrial Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Delta-1-pyrroline-5-carboxylate synthase Dihydrolipoyl dehydrogenase, mitochondrial Dynamin-like GTPase OPA1, mitochondrial Enoyl-CoA delta isomerase 1, mitochondrial Essential MCU regulator, mitochondrial Ferrochelatase, mitochondrial Fumarate hydratase, mitochondrial Glutamate dehydrogenase 1, mitochondrial Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Hydroxymethylglutaryl-CoA synthase, mitochondrial Isobutyryl-CoA dehydrogenase, mitochondrial Isocitrate dehydrogenase [NADP], mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Isoleucine--tRNA ligase, mitochondrial Large ribosomal subunit protein bL12m Large ribosomal subunit protein bL32m Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial Lon protease homolog, mitochondrial Malate dehydrogenase, mitochondrial Metalloendopeptidase OMA1, mitochondrial Mitochondrial import inner membrane translocase subunit Tim10 Mitochondrial import inner membrane translocase subunit Tim17-A Mitochondrial import inner membrane translocase subunit Tim22 Mitochondrial import inner membrane translocase subunit Tim9 Mitochondrial inner membrane m-AAA protease component AFG3L2 Mitochondrial inner membrane m-AAA protease component paraplegin Mitochondrial-processing peptidase subunit alpha NAD kinase 2, mitochondrial NAD-dependent malic enzyme, mitochondrial NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NADH-ubiquinone oxidoreductase chain 1 NADH-ubiquinone oxidoreductase chain 2 NADH-ubiquinone oxidoreductase chain 5 NADH-ubiquinone oxidoreductase chain 6 PRELI domain-containing protein 1, mitochondrial Probable D-lactate dehydrogenase, mitochondrial Propionyl-CoA carboxylase beta chain, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Serine hydroxymethyltransferase, mitochondrial Serine protease HTRA2, mitochondrial Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Single-stranded DNA-binding protein, mitochondrial Small ribosomal subunit protein uS10m Small ribosomal subunit protein uS2m StAR-related lipid transfer protein 7, mitochondrial Steroidogenic acute regulatory protein, mitochondrial Stress-70 protein, mitochondrial Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial Succinyl-CoA TP53-regulated inhibitor of apoptosis 1 Transcription factor A, mitochondrial Twinkle mtDNA helicase [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial cAMP-dependent protein kinase catalytic subunit alpha	O14949 O43464 O43678 O43715 O60313 O75390 O75489 O75947 O75964 O76031 O95139 P00367 P00395 P00403 P00846 P03886 P03891 P03915 P03923 P05091 P05141 P05166 P06576 P07954 P08559 P09622 P10606 P10809 P11177 P11182 P12236 P13073 P13196 P17612 P18859 P20674 P22695 P22830 P23368 P24752 P25705 P28331 P30837 P34897 P36542 P36776 P38646 P40926 P42126 P45954 P48047 P48735 P49675 P49753 P49821 P50213 P52815 P54868 P54886 P55809 P56181 P62072 P78540 P82664 Q00059 Q02218 Q02338 Q04837 Q10713 Q13011 Q15118 Q16740 Q16836 Q4G0N4 Q86WU2 Q8IYU8 Q96E52 Q96I99 Q96RR1 Q96TA2 Q99595 Q99714 Q99798 Q9BYC8 Q9H4I9 Q9NQZ5 Q9NSE4 Q9NWU1 Q9P0J0 Q9UKU7 Q9UQ90 Q9Y255 Q9Y399 Q9Y4W6 Q9Y584 Q9Y5J7 Q9Y6H1	15E1.1 AAC2 AAC3 ACAD8 ACADSB ACAT ACAT1 ACO2 ACOT2 AFG3L2 ALAS1 ALAS3 ALASH ALDH18A1 ALDH1B1 ALDH2 ALDH5 ALDHX ALDM ANT2 ANT3 ARC42 ARG2 ATP5A ATP5A1 ATP5AL2 ATP5B ATP5C ATP5C1 ATP5CL1 ATP5F1A ATP5F1B ATP5F1C ATP5H ATP5J ATP5L ATP5MG ATP5O ATP5PD ATP5PF ATP5PO ATP6 ATPASE6 ATPM ATPMB ATPO ATPSB BCATE2 BCKDHE2 BDH BDH1 C10orf2 C22orf32 C5orf33 C7orf17 CAR CHCHD2 CLPP CLPX CMAR COI COII COX2 COX4 COX4I1 COX5A COX5B COXI COXII CS DBT DCI DLD ECH1 ECI1 EFHA1 EMRE ERAB FECH FH FTSH1 GCSL GLUD GLUD1 GRIM19 GRP75 GSAS GTT1 HAD HAD1 HADH HADH2 HADHSC HMGCS2 HSD17B10 HSP60 HSPA9 HSPA9B HSPD1 HTRA2 IARS2 IBD IDH2 IDH3A INPP5E KIAA0123 KIAA0567 LAD LDHD LONP1 MAT MDH2 ME2 MICU2 MIMT17 MNADK MPPA MPRP1 MRPL12 MRPL32 MRPL7 MRPP2 MRPS10 MRPS2 MT-ATP6 MT-CO1 MT-CO2 MT-ND1 MT-ND2 MT-ND5 MT-ND6 MTATP6 MTCO1 MTCO2 MTND1 MTND2 MTND5 MTND6 NADH1 NADH2 NADH5 NADH6 NADK2 NADKD1 ND1 ND2 ND5 ND6 NDUFA13 NDUFA2 NDUFB6 NDUFS1 NDUFS3 NDUFV1 NDUFV3 OGDH OMA1 OMI OPA1 OXCT OXCT1 OXSM P5CS PCCB PDHA1 PDHB PDHK1 PDK1 PEO1 PGN PHE1A PHE1B PHE3 PKACA PMPCA PRELI PRELID1 PRKACA PRSS15 PRSS25 PTE2 PTE2A PYCS RPML12 SCHAD SCOT SDR5C1 SDR9C1 SHMT2 SLC25A5 SLC25A6 SMDT1 SPG7 SSBP SSBP1 STAR STARD1 STARD7 SUCLG2 TCF6 TCF6L2 TEX4 TFAM TIM10 TIM17 TIM17A TIM22 TIM9 TIM9A TIMM10 TIMM17 TIMM17A TIMM22 TIMM9 TIMM9A TRIAP1 TWNK UQCRC2 UQCRQ UQOR1 XH98G2 YME1L YME1L1 mt-HSP70	Homo sapiens (human)
Formation of apoptosome	Apoptotic protease-activating factor 1 Caspase recruitment domain-containing protein 8 Caspase-9 Cell death regulator Aven Cytochrome c Methylthioribulose-1-phosphate dehydratase	O14727 P55211 P99999 Q96GX9 Q9NQS1 Q9Y2G2	APAF1 APIP AVEN CARD8 CASP9 CYC CYCS DACAR KIAA0413 KIAA0955 MCH6 NDPP1	Homo sapiens (human)
Mitochondrial tRNA aminoacylation	Alanine--tRNA ligase, mitochondrial Asparaginyl-tRNA synthetase Aspartate--tRNA ligase, mitochondrial Glutamine--tRNA ligase Glycine--tRNA ligase Histidine--tRNA ligase, mitochondrial Inorganic pyrophosphatase 2, mitochondrial Isoleucine--tRNA ligase, mitochondrial Leucine--tRNA ligase, mitochondrial Lysine--tRNA ligase Methionine--tRNA ligase, mitochondrial Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial Phenylalanine--tRNA ligase, mitochondrial Probable arginine--tRNA ligase, mitochondrial Probable cysteine--tRNA ligase, mitochondrial Probable proline--tRNA ligase, mitochondrial Serine--tRNA ligase, mitochondrial Threonine--tRNA ligase, mitochondrial Tryptophan--tRNA ligase, mitochondrial Tyrosine--tRNA ligase, mitochondrial Valine--tRNA ligase, mitochondrial	O95363 P41250 P47897 P49590 Q15031 Q15046 Q5JPH6 Q5JTZ9 Q5ST30 Q5T160 Q6PI48 Q7L3T8 Q96GW9 Q96I59 Q9BW92 Q9H2U2 Q9HA77 Q9NP81 Q9NSE4 Q9UGM6 Q9Y2Z4	AARS2 AARSL CARS2 DARS2 EARS2 FARS1 FARS2 GARS GARS1 HARS2 HARSL HARSR HO3 IARS2 KARS KARS1 KIAA0028 KIAA0070 KIAA1270 KIAA1885 KIAA1970 LARS2 MARS2 NARS2 PARS2 PPA2 QARS QARS1 RARS2 RARSL SARS2 SARSM TARS2 TARSL1 VARS2 VARS2L VARSL WARS2 YARS2	Homo sapiens (human)
p38MAPK events	GTPase HRas GTPase NRas MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 13 Mitogen-activated protein kinase 14 Ral guanine nucleotide dissociation stimulator Ras-related protein Ral-A Ras-related protein Ral-B	O15264 P01111 P01112 P11233 P11234 P49137 P53778 Q12967 Q15759 Q16539 Q16644	CSBP CSBP1 CSBP2 CSPB1 ERK6 HRAS HRAS1 KIAA1308 MAPK11 MAPK12 MAPK13 MAPK14 MAPKAPK2 MAPKAPK3 MXI2 NRAS PRKM11 PRKM13 RAL RALA RALB RALGDS RGF SAPK2 SAPK2A SAPK2B SAPK3 SAPK4	Homo sapiens (human)
Breakdown of the nuclear lamina	Caspase-6 Lamin-B1	P20700 P55212	CASP6 LMN2 LMNB LMNB1 MCH2	Homo sapiens (human)
TLR3 deficiency - HSE	Toll-like receptor 3	O15455	TLR3	Homo sapiens (human)
Chromatin modifying enzymes	Bromodomain and WD repeat-containing protein 1 Histone H3.1 Histone H3.2 Protein-arginine deiminase type-1 Protein-arginine deiminase type-2 Protein-arginine deiminase type-3 Protein-arginine deiminase type-4 Protein-arginine deiminase type-6 Transcription activator BRG1	P51532 P68431 Q6TGC4 Q71DI3 Q9NSI6 Q9ULC6 Q9ULW8 Q9UM07 Q9Y2J8	BAF190A BRG1 BRWD1 C21orf107 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST2H3A HIST2H3C HIST2H3D KIAA0994 PAD1 PAD2 PAD3 PAD4 PAD6 PADI1 PADI2 PADI3 PADI4 PADI5 PADI6 PDI1 PDI2 PDI3 PDI5 SMARCA4 SNF2B SNF2L4 WDR9	Homo sapiens (human)
Peptide chain elongation	Elongation factor 1-alpha 1 Elongation factor 2 Large ribosomal subunit protein P1 Large ribosomal subunit protein P2 Large ribosomal subunit protein eL13 Large ribosomal subunit protein eL14 Large ribosomal subunit protein eL15 Large ribosomal subunit protein eL18 Large ribosomal subunit protein eL19 Large ribosomal subunit protein eL20 Large ribosomal subunit protein eL21 Large ribosomal subunit protein eL22 Large ribosomal subunit protein eL24 Large ribosomal subunit protein eL27 Large ribosomal subunit protein eL28 Large ribosomal subunit protein eL29 Large ribosomal subunit protein eL30 Large ribosomal subunit protein eL31 Large ribosomal subunit protein eL32 Large ribosomal subunit protein eL33 Large ribosomal subunit protein eL34 Large ribosomal subunit protein eL36 Large ribosomal subunit protein eL37 Large ribosomal subunit protein eL38 Large ribosomal subunit protein eL39 Large ribosomal subunit protein eL42 Large ribosomal subunit protein eL43 Large ribosomal subunit protein eL6 Large ribosomal subunit protein eL8 Large ribosomal subunit protein uL10 Large ribosomal subunit protein uL11 Large ribosomal subunit protein uL13 Large ribosomal subunit protein uL14 Large ribosomal subunit protein uL15 Large ribosomal subunit protein uL16 Large ribosomal subunit protein uL18 Large ribosomal subunit protein uL1 Large ribosomal subunit protein uL22 Large ribosomal subunit protein uL23 Large ribosomal subunit protein uL24 Large ribosomal subunit protein uL29 Large ribosomal subunit protein uL2 Large ribosomal subunit protein uL30 Large ribosomal subunit protein uL3 Large ribosomal subunit protein uL4 Large ribosomal subunit protein uL5 Large ribosomal subunit protein uL6 Ribosomal protein eL22-like Ribosomal protein eL39-like 2 Ribosomal protein eL42-like Ribosomal protein eS27-like Ribosomal protein uL16-like Ribosomal protein uL24-like Ribosomal protein uL3-like Small ribosomal subunit protein eS10 Small ribosomal subunit protein eS12 Small ribosomal subunit protein eS17 Small ribosomal subunit protein eS19 Small ribosomal subunit protein eS1 Small ribosomal subunit protein eS21 Small ribosomal subunit protein eS24 Small ribosomal subunit protein eS25 Small ribosomal subunit protein eS26 Small ribosomal subunit protein eS27 Small ribosomal subunit protein eS28 Small ribosomal subunit protein eS32 Small ribosomal subunit protein eS4, X isoform Small ribosomal subunit protein eS4, Y isoform 1 Small ribosomal subunit protein eS4, Y isoform 2 Small ribosomal subunit protein eS6 Small ribosomal subunit protein eS7 Small ribosomal subunit protein eS8 Small ribosomal subunit protein uS10 Small ribosomal subunit protein uS11 Small ribosomal subunit protein uS12 Small ribosomal subunit protein uS13 Small ribosomal subunit protein uS14 Small ribosomal subunit protein uS15 Small ribosomal subunit protein uS17 Small ribosomal subunit protein uS19 Small ribosomal subunit protein uS2 Small ribosomal subunit protein uS3 Small ribosomal subunit protein uS4 Small ribosomal subunit protein uS5 Small ribosomal subunit protein uS7 Small ribosomal subunit protein uS8 Small ribosomal subunit protein uS9 Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P05386 P05387 P05388 P08708 P08865 P13639 P15880 P18077 P18124 P18621 P22090 P23396 P25398 P26373 P27635 P30050 P32969 P35268 P36578 P39019 P39023 P40429 P42677 P42766 P46776 P46777 P46778 P46779 P46781 P46782 P46783 P47914 P49207 P50914 P60866 P61247 P61254 P61313 P61353 P61513 P61927 P62081 P62241 P62244 P62249 P62263 P62266 P62269 P62273 P62277 P62280 P62424 P62701 P62750 P62753 P62829 P62841 P62847 P62851 P62854 P62857 P62861 P62888 P62891 P62899 P62906 P62910 P62913 P62917 P62945 P62979 P62987 P63173 P63220 P68104 P83731 P83881 P84098 Q02543 Q02878 Q07020 Q6P5R6 Q71UM5 Q8TD47 Q92901 Q969Q0 Q96EH5 Q96L21 Q9UNX3 Q9Y3U8	BBC1 CCG2 D11S2243E D6S218E DXS648E EC45 EEF1A EEF1A1 EEF2 EF1A EF2 FAU FTE1 LAMBR LAMR1 LENG7 MFTL MPS1 NEDD6 QM RIG RPL1 RPL10 RPL10A RPL10L RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL22L1 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL26P1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL36AL RPL37 RPL37A RPL38 RPL39 RPL39L RPL39L1 RPL3L RPL4 RPL41 RPL44 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPL9P7 RPL9P8 RPL9P9 RPLP0 RPLP1 RPLP2 RPP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS17L RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS27L RPS28 RPS29 RPS3 RPS3A RPS4 RPS4X RPS4Y RPS4Y1 RPS4Y2 RPS4Y2P RPS5 RPS6 RPS7 RPS8 RPS9 RPSA RRP1 SCAR SURF-3 SURF3 TXREB1 UBA52 UBA80 UBCEP1 UBCEP2	Homo sapiens (human)
Defective ABCC6 causes PXE	ATP-binding cassette sub-family C member 6	O95255	ABCC6 ARA MRP6	Homo sapiens (human)
MASTL Facilitates Mitotic Progression	Alpha-endosulfine Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 Serine/threonine-protein kinase greatwall Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform cAMP-regulated phosphoprotein 19	O43768 P06493 P14635 P30153 P30154 P56211 P62714 P67775 Q66LE6 Q96GX5	ARPP19 CCNB CCNB1 CDC2 CDC28A CDK1 CDKN1 ENSA GW GWL KIAA1541 MASTL P34CDC2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2D THC2	Homo sapiens (human)
Formation of tubulin folding intermediates by CCT/TriC	Putative tubulin-like protein alpha-4B T-complex protein 1 subunit alpha T-complex protein 1 subunit beta T-complex protein 1 subunit delta T-complex protein 1 subunit epsilon T-complex protein 1 subunit eta T-complex protein 1 subunit gamma T-complex protein 1 subunit theta T-complex protein 1 subunit zeta-2 T-complex protein 1 subunit zeta Tubulin alpha chain-like 3 Tubulin alpha-1A chain Tubulin alpha-1B chain Tubulin alpha-1C chain Tubulin alpha-3C chain Tubulin alpha-3D chain Tubulin alpha-3E chain Tubulin alpha-4A chain Tubulin alpha-8 chain Tubulin beta-1 chain Tubulin beta-2A chain Tubulin beta-2B chain Tubulin beta-3 chain Tubulin beta-4A chain Tubulin beta-4B chain Tubulin beta-6 chain	A6NHL2 P04350 P0DPH7 P0DPH8 P17987 P40227 P48643 P49368 P50990 P50991 P68363 P68366 P68371 P78371 Q13509 Q13885 Q6PEY2 Q71U36 Q92526 Q99832 Q9BQE3 Q9BUF5 Q9BVA1 Q9H4B7 Q9H853 Q9NY65	99D8.1 C21orf112 CCT1 CCT2 CCT3 CCT4 CCT5 CCT6 CCT6A CCT6B CCT7 CCT8 CCTA CCTB CCTD CCTE CCTG CCTH CCTQ CCTZ KIAA0002 KIAA0098 NIP7-1 SRB TCP1 TRIC5 TUBA1 TUBA1A TUBA1B TUBA1C TUBA2 TUBA3 TUBA3C TUBA3D TUBA3E TUBA4 TUBA4A TUBA4B TUBA6 TUBA8 TUBAL2 TUBAL3 TUBB1 TUBB2 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4A TUBB4B TUBB5 TUBB6	Homo sapiens (human)
activated TAK1 mediates p38 MAPK activation	Dual specificity mitogen-activated protein kinase kinase 3 Dual specificity mitogen-activated protein kinase kinase 6 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase-like 2 MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Nucleotide-binding oligomerization domain-containing protein 1 Nucleotide-binding oligomerization domain-containing protein 2 Receptor-interacting serine/threonine-protein kinase 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	O43187 O43318 O43353 P46734 P49137 P51617 P52564 P61088 Q13404 Q15750 Q15759 Q16539 Q16644 Q8N5C8 Q9HC29 Q9NYJ8 Q9Y239 Q9Y4K3 Q9Y6K9	BLU CARD15 CARD4 CARDIAK CROC1 CSBP CSBP1 CSBP2 CSPB1 FIP3 IKBKG IRAK IRAK1 IRAK2 KIAA0733 MAP2K3 MAP2K6 MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 MAPK11 MAPK14 MAPKAPK2 MAPKAPK3 MEK3 MEK6 MKK3 MKK6 MXI2 NEMO NOD1 NOD2 PRKM11 PRKMK3 PRKMK6 RICK RIP2 RIPK2 RNF85 SAPK2 SAPK2A SAPK2B SKK2 SKK3 TAB1 TAB2 TAB3 TAK1 TRAF6 UBE2N UBE2V UBE2V1 UEV1	Homo sapiens (human)
Toll Like Receptor 7/8 (TLR7/8) Cascade	Toll-like receptor 7 Toll-like receptor 8	Q9NR97 Q9NYK1	TLR7 TLR8	Homo sapiens (human)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	Interferon regulatory factor 7 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Myeloid differentiation primary response protein MyD88 TNF receptor-associated factor 6 Toll-like receptor 7 Toll-like receptor 9 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	P51617 P61088 Q13404 Q92985 Q99836 Q9NR96 Q9NWZ3 Q9NYK1 Q9Y4K3	BLU CROC1 IRAK IRAK1 IRAK4 IRF7 MYD88 RNF85 TLR7 TLR9 TRAF6 UBE2N UBE2V UBE2V1 UEV1	Homo sapiens (human)
Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)	Chloride anion exchanger	P40879	DRA SLC26A3	Homo sapiens (human)
Defective MTR causes HMAG	Methionine synthase reductase Methionine synthase	Q99707 Q9UBK8	MTR MTRR	Homo sapiens (human)
Signaling by Hippo	14-3-3 protein beta/alpha 14-3-3 protein epsilon Angiomotin-like protein 1 Angiomotin-like protein 2 Caspase-3 MOB kinase activator 1A MOB kinase activator 1B Nephrocystin-4 Protein KIBRA Protein salvador homolog 1 Segment polarity protein dishevelled homolog DVL-2 Serine/threonine-protein kinase 3 Serine/threonine-protein kinase 4 Serine/threonine-protein kinase LATS1 Serine/threonine-protein kinase LATS2 Tight junction protein ZO-1 Tight junction protein ZO-2 Transcriptional coactivator YAP1 WW domain-containing transcription regulator protein 1	O14641 O75161 O95835 P31946 P42574 P46937 P62258 Q07157 Q13043 Q13188 Q7L9L4 Q8IX03 Q8IY63 Q9GZV5 Q9H4B6 Q9H8S9 Q9NRM7 Q9UDY2 Q9Y2J4	AMOTL1 AMOTL2 C2orf6 CASP3 CPP32 DVL2 KIAA0673 KIAA0869 KIAA0989 KIBRA KPM KRS1 KRS2 LATS1 LATS2 MOB1A MOB1B MOB4A MOB4B MOBK1B MOBKL1A MOBKL1B MST1 MST2 NPHP4 SAV1 STK3 STK4 TAZ TJP1 TJP2 WARTS WW45 WWC1 WWTR1 X104 YAP1 YAP65 YWHAB YWHAE ZO1 ZO2	Homo sapiens (human)
Regulation of TP53 Activity through Methylation	Cellular tumor antigen p53 E3 ubiquitin-protein ligase Mdm2 Histone acetyltransferase p300 Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Junction-mediating and -regulatory protein Lethal(3)malignant brain tumor-like protein 1 N-lysine methyltransferase KMT5A N-lysine methyltransferase SMYD2 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Protein arginine N-methyltransferase 5 SET domain-containing protein 9 Serine-protein kinase ATM Serine/threonine-protein kinase Chk2 Tetratricopeptide repeat protein 5 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14744 O15151 O96017 P04637 P0CG47 P0CG48 P62979 P62987 Q00987 Q09472 Q13315 Q8N0Z6 Q8N9B5 Q8NE22 Q96KQ7 Q9H9B1 Q9NQR1 Q9NRG4 Q9Y468	ATM BAT8 C5orf35 C6orf30 CDS1 CHEK2 CHK2 EHMT1 EHMT2 EP300 EUHMTASE1 G9A GLP HRMT1L5 IBP72 JBP1 JMY KIAA0681 KIAA1876 KMT1C KMT1D KMT3C KMT5A L3MBT L3MBTL L3MBTL1 MDM2 MDM4 MDMX NG36 P300 P53 PRMT5 PRSET7 RAD53 RPS27A SET07 SET8 SETD8 SETD9 SKB1 SMYD2 TP53 TTC5 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Signaling by LRP5 mutants	Dickkopf-related protein 1 Dickkopf-related protein 2 Dickkopf-related protein 4 Kremen protein 1 Kremen protein 2 Low-density lipoprotein receptor-related protein 5	O75197 O94907 Q8NCW0 Q96MU8 Q9UBT3 Q9UBU2	DKK1 DKK2 DKK4 KREMEN KREMEN1 KREMEN2 KRM1 KRM2 LR3 LRP5 LRP7	Homo sapiens (human)
Defective B3GALTL causes PpS	A disintegrin and metalloproteinase with thrombospondin motifs 10 A disintegrin and metalloproteinase with thrombospondin motifs 12 A disintegrin and metalloproteinase with thrombospondin motifs 13 A disintegrin and metalloproteinase with thrombospondin motifs 14 A disintegrin and metalloproteinase with thrombospondin motifs 15 A disintegrin and metalloproteinase with thrombospondin motifs 16 A disintegrin and metalloproteinase with thrombospondin motifs 17 A disintegrin and metalloproteinase with thrombospondin motifs 18 A disintegrin and metalloproteinase with thrombospondin motifs 19 A disintegrin and metalloproteinase with thrombospondin motifs 1 A disintegrin and metalloproteinase with thrombospondin motifs 20 A disintegrin and metalloproteinase with thrombospondin motifs 2 A disintegrin and metalloproteinase with thrombospondin motifs 3 A disintegrin and metalloproteinase with thrombospondin motifs 4 A disintegrin and metalloproteinase with thrombospondin motifs 5 A disintegrin and metalloproteinase with thrombospondin motifs 6 A disintegrin and metalloproteinase with thrombospondin motifs 7 A disintegrin and metalloproteinase with thrombospondin motifs 8 A disintegrin and metalloproteinase with thrombospondin motifs 9 ADAMTS-like protein 1 ADAMTS-like protein 2 ADAMTS-like protein 3 ADAMTS-like protein 4 ADAMTS-like protein 5 Beta-1,3-glucosyltransferase Properdin SCO-spondin Semaphorin-5A Semaphorin-5B Somatomedin-B and thrombospondin type-1 domain-containing protein Spondin-1 Spondin-2 Thrombospondin type-1 domain-containing protein 1 Thrombospondin type-1 domain-containing protein 4 Thrombospondin type-1 domain-containing protein 7A Thrombospondin type-1 domain-containing protein 7B Thrombospondin-1 Thrombospondin-2	A2VEC9 O15072 O75173 O95450 P07996 P27918 P35442 P58397 P59510 P82987 Q13591 Q6UY14 Q6Y288 Q6ZMM2 Q6ZMP0 Q76LX8 Q86TH1 Q8IVN8 Q8N6G6 Q8TE56 Q8TE57 Q8TE58 Q8TE59 Q8TE60 Q8WXS8 Q9BUD6 Q9C0I4 Q9H324 Q9HCB6 Q9NS62 Q9P283 Q9P2N4 Q9UHI8 Q9UKP4 Q9UKP5 Q9UNA0 Q9UP79 Q9UPZ6	ADAMTS1 ADAMTS10 ADAMTS11 ADAMTS12 ADAMTS13 ADAMTS14 ADAMTS15 ADAMTS16 ADAMTS17 ADAMTS18 ADAMTS19 ADAMTS2 ADAMTS20 ADAMTS21 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS6 ADAMTS7 ADAMTS8 ADAMTS9 ADAMTSL1 ADAMTSL2 ADAMTSL3 ADAMTSL4 ADAMTSL5 ADAMTSR1 ADMP2 B3GALTL B3GLCT B3GTL C8orf84 C9orf8 C9orf94 CFP DIL1 KIAA0366 KIAA0605 KIAA0688 KIAA0762 KIAA0960 KIAA1233 KIAA1312 KIAA1346 KIAA1445 KIAA1679 KIAA2029 KIAA2036 METH1 METH2 PCINP PCPNI PFC RPESP SBSPON SEMA5A SEMA5B SEMAF SEMAG SPON1 SPON2 SSPO SSPOP THBS1 THBS2 THSD1 THSD4 THSD6 THSD7A THSD7B TMTSP TSP TSP1 TSP2 TSRC1 VSGP	Homo sapiens (human)

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