GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **501 - 525** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
TNF signaling	BAG family molecular chaperone regulator 4 Disintegrin and metalloproteinase domain-containing protein 17 Receptor-interacting serine/threonine-protein kinase 1 TNF receptor-associated factor 2 Tumor necrosis factor receptor superfamily member 1A Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor	O95429 P01375 P19438 P78536 Q12933 Q13546 Q15628	ADAM17 BAG4 CSVP RIP RIP1 RIPK1 SODD TACE TNF TNFA TNFAR TNFR1 TNFRSF1A TNFSF2 TRADD TRAF2 TRAP3	Homo sapiens (human)
Degradation of the extracellular matrix	72 kDa type IV collagenase A disintegrin and metalloproteinase with thrombospondin motifs 16 A disintegrin and metalloproteinase with thrombospondin motifs 18 A disintegrin and metalloproteinase with thrombospondin motifs 1 A disintegrin and metalloproteinase with thrombospondin motifs 4 A disintegrin and metalloproteinase with thrombospondin motifs 5 A disintegrin and metalloproteinase with thrombospondin motifs 8 A disintegrin and metalloproteinase with thrombospondin motifs 9 Aggrecan core protein Alpha-2-macroglobulin Basement membrane-specific heparan sulfate proteoglycan core protein Basigin Bone morphogenetic protein 1 Brevican core protein CD44 antigen Cadherin-1 Calpain small subunit 1 Calpain small subunit 2 Calpain-1 catalytic subunit Calpain-10 Calpain-11 Calpain-12 Calpain-13 Calpain-14 Calpain-15 Calpain-2 catalytic subunit Calpain-3 Calpain-5 Calpain-6 Calpain-7 Calpain-8 Calpain-9 Calpastatin Caspase-3 Cathepsin G Cathepsin K Cathepsin L2 Cathepsin S Collagenase 3 Decorin Disintegrin and metalloproteinase domain-containing protein 10 Disintegrin and metalloproteinase domain-containing protein 15 Disintegrin and metalloproteinase domain-containing protein 8 Interstitial collagenase Kallikrein-7 Laminin subunit alpha-3 Laminin subunit alpha-5 Laminin subunit beta-1 Laminin subunit beta-3 Laminin subunit gamma-1 Laminin subunit gamma-2 Macrophage metalloelastase Matrilysin Matrix metalloproteinase-14 Matrix metalloproteinase-15 Matrix metalloproteinase-19 Matrix metalloproteinase-20 Matrix metalloproteinase-9 Neutrophil collagenase Neutrophil elastase Nicastrin Nidogen-1 Opticin Osteopontin Plasminogen Presenilin-1 Procathepsin L Serine protease HTRA1 Signal peptide, CUB and EGF-like domain-containing protein 1 Signal peptide, CUB and EGF-like domain-containing protein 3 Stromelysin-1 Stromelysin-2 Stromelysin-3 Tolloid-like protein 1 Tolloid-like protein 2 Transmembrane protease serine 6	A6NHC0 A8MX76 O14672 O14815 O15230 O15484 O43897 O60882 O60911 O75173 O75808 P00747 P01023 P03956 P04632 P07384 P07585 P07711 P07942 P08246 P08253 P08254 P08311 P09237 P09238 P10451 P11047 P12830 P13497 P14543 P14780 P16070 P16112 P17655 P20807 P20810 P22894 P24347 P25774 P35613 P39900 P42574 P43235 P45452 P49768 P49862 P50281 P51511 P78325 P98160 Q13444 Q13751 Q13753 Q16787 Q6MZZ7 Q6ZSI9 Q8IU80 Q8IWY4 Q8IX30 Q8TE57 Q8TE60 Q92542 Q92743 Q96GW7 Q96L46 Q99542 Q9HC96 Q9P2N4 Q9UBM4 Q9UHI8 Q9UMQ6 Q9UNA0 Q9UP79 Q9Y6L7 Q9Y6Q1 Q9Y6W3	A2M ACAN AD3 ADAM10 ADAM15 ADAM8 ADAMTS1 ADAMTS11 ADAMTS16 ADAMTS18 ADAMTS21 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADMP2 AGC1 BCAN BEHAB BMP1 BNSP BSG CALPM CANP3 CANPL1 CANPL2 CANPL3 CANPX CAPN1 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPN15 CAPN2 CAPN3 CAPN4 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPNS CAPNS1 CAPNS2 CASP3 CAST CATL2 CD44 CDH1 CDHE CEGF3 CLG CLG1 CLG4A CLG4B CPAMD5 CPP32 CSPG1 CSPG7 CTSG CTSK CTSL CTSL1 CTSL2 CTSO CTSO2 CTSS CTSU CTSV DCN ELA2 ELANE HME HSPG2 HTRA HTRA1 KIAA0253 KIAA0533 KIAA0688 KIAA0932 KIAA1312 KIAA1346 KIAA1845 KIAA1907 KIAA2029 KLK7 KUZ LAMA3 LAMA5 LAMB1 LAMB2 LAMB2T LAMB3 LAMC1 LAMC2 LAMNA LAMNB1 LAMNB2 LHR MADM MDC15 MDU2 MDU3 METH1 METH2 MIC4 MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP18 MMP19 MMP2 MMP20 MMP3 MMP7 MMP8 MMP9 MPSL1 MS2 MSK16 NCL1 NCL2 NCL3 NCL4 NCSTN NID NID1 OPN OPT OPTC PALBH PCOLC PLG PRSS11 PRSS6 PS1 PSEN1 PSNL1 PUMP1 RASI SCCE SCUBE1 SCUBE3 SLRR1B SOLH SPP1 STMY1 STMY2 STMY3 TLL TLL1 TLL2 TMPRSS6 UVO	Homo sapiens (human)
Signaling by ERBB2 KD Mutants	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Epidermal growth factor receptor Erbin GRB2-associated-binding protein 1 GTPase HRas GTPase NRas Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Receptor tyrosine-protein kinase erbB-2 SHC-transforming protein 1 Son of sevenless homolog 1	O14511 O14944 P00533 P01111 P01112 P01133 P04626 P07900 P19174 P27986 P29353 P35070 P42336 P56975 Q02297 Q07889 Q13480 Q16543 Q8WWG1 Q96RT1 Q99075	BTC CDC37 CDC37A DTR DTS EGF EGFR ERBB ERBB1 ERBB2 ERBB2IP ERBIN EREG GAB1 GGF GRB1 HBEGF HEGFL HER1 HER2 HGL HRAS HRAS1 HRGA HSP90A HSP90AA1 HSPC1 HSPCA KIAA1225 LAP2 MLN19 NDF NEU NGL NRAS NRG1 NRG2 NRG3 NRG4 NTAK PIK3CA PIK3R1 PLC1 PLCG1 SHC SHC1 SHCA SMDF SOS1	Homo sapiens (human)
Cyclin A:Cdk2-associated events at S phase entry	CDK-activating kinase assembly factor MAT1 CDK5 and ABL1 enzyme substrate 1 Cyclin-A1 Cyclin-A2 Cyclin-H Cyclin-dependent kinase 2 Cyclin-dependent kinase 7 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Fizzy-related protein homolog Histone-binding protein RBBP4 M-phase inducer phosphatase 1 M-phase inducer phosphatase 2 Myc proto-oncogene protein Protein lin-37 homolog Protein lin-52 homolog Protein lin-54 homolog Protein lin-9 homolog Protein max RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Retinoblastoma-associated protein Retinoblastoma-like protein 2 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F4 Transcription factor E2F5 Wee1-like protein kinase	P01106 P06400 P20248 P24941 P30291 P30304 P30305 P31749 P31751 P38936 P46527 P50613 P51946 P51948 P61244 P78396 Q01094 Q08999 Q09028 Q14186 Q14188 Q15329 Q16254 Q52LA3 Q5TKA1 Q6MZP7 Q8TDN4 Q96GY3 Q9UM11 Q9Y243	AKT1 AKT2 AKT3 BARA BHLHD4 BHLHE39 C14orf46 CABLES CABLES1 CAK CAK1 CAP20 CAP35 CCN1 CCNA CCNA1 CCNA2 CCNH CDC25A CDC25B CDC25HU2 CDH1 CDK2 CDK7 CDKN1 CDKN1A CDKN1B CDKN2 CDKN7 CIP1 CXCDC1 DP1 DP2 E2F1 E2F4 E2F5 FYR FZR FZR1 KIAA1242 KIAA2037 KIP1 LIN37 LIN52 LIN54 LIN9 MAT1 MAX MDA6 MNAT1 MO15 MYC PIC1 PKB PKBG RAC RB1 RB2 RBAP48 RBBP3 RBBP4 RBL2 RNF66 SDI1 STK1 TFDP1 TFDP2 TGS WAF1 WEE1 p27	Homo sapiens (human)
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	Histone-lysine N-methyltransferase 2C Histone-lysine N-methyltransferase 2D Lysine-specific demethylase 6A Nuclear receptor coactivator 6 PAX-interacting protein 1 PAXIP1-associated glutamate-rich protein 1 Protein dpy-30 homolog Retinoblastoma-binding protein 5 Set1/Ash2 histone methyltransferase complex subunit ASH2 WD repeat-containing protein 5	O14686 O15550 P61964 Q14686 Q15291 Q6ZW49 Q8NEZ4 Q9BTK6 Q9C005 Q9UBL3	AIB3 ALR ASH2L ASH2L1 BIG3 C16orf53 DPY30 HALR KDM6A KIAA0181 KIAA1506 KMT2C KMT2D MLL2 MLL3 MLL4 NCOA6 PA1 PAGR1 PAXIP1 PAXIP1L PTIP RAP250 RBBP5 RBQ3 TRBP UTX WDR5	Homo sapiens (human)
SDK interactions	Protein sidekick-1 Protein sidekick-2	Q58EX2 Q7Z5N4	KIAA1514 SDK1 SDK2	Homo sapiens (human)
NOSTRIN mediated eNOS trafficking	Actin nucleation-promoting factor WASL Caveolin-1 Dynamin-2 Nitric oxide synthase 3 Nostrin	O00401 P29474 P50570 Q03135 Q8IVI9	CAV CAV1 DNM2 DYN2 NOS3 NOSTRIN WASL	Homo sapiens (human)
Aggrephagy	ADP-ribosylation factor-like protein 13B Centrin-1 Cystic fibrosis transmembrane conductance regulator Cytoplasmic dynein 1 heavy chain 1 Cytoplasmic dynein 1 intermediate chain 1 Cytoplasmic dynein 1 intermediate chain 2 Cytoplasmic dynein 1 light intermediate chain 1 Cytoplasmic dynein 1 light intermediate chain 2 Dynein light chain 1, cytoplasmic Dynein light chain 2, cytoplasmic E3 ubiquitin-protein ligase parkin Heat shock factor protein 1 Heat shock protein HSP 90-alpha Histone deacetylase 6 Intraflagellar transport protein 88 homolog Parkinson disease protein 7 Pericentrin Polyubiquitin-B Polyubiquitin-C Transitional endoplasmic reticulum ATPase Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14576 O43237 O60260 O95613 P07900 P0CG47 P0CG48 P13569 P55072 P61088 P62979 P62987 P63167 Q00613 Q12798 Q13099 Q13404 Q13409 Q14204 Q3SXY8 Q96FJ2 Q99497 Q9UBN7 Q9Y6G9	ABCC7 ARL13B ARL2L1 BLU CEN1 CETN CETN1 CFTR CROC1 DHC1 DLC1 DLC2 DNCH1 DNCI1 DNCI2 DNCIC1 DNCIC2 DNCL DNCL1 DNCLC1 DNCLI1 DNCLI2 DNECL DYHC DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 HDAC6 HDLC1 HEL-220 HEL-S-70 HSF1 HSP90A HSP90AA1 HSPC1 HSPCA HSTF1 IFT88 KIAA0325 KIAA0402 KIAA0901 LIC2 PARK2 PARK7 PCNT PCNT2 PRKN RPS27A TG737 TTC10 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBE2N UBE2V UBE2V1 UEV1 VCP	Homo sapiens (human)
PTK6 Regulates Cell Cycle	Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 Cyclin-dependent kinase inhibitor 1B G1/S-specific cyclin-D1 G1/S-specific cyclin-E1 Protein-tyrosine kinase 6	P11802 P24385 P24864 P24941 P46527 Q13882	BCL1 BRK CCND1 CCNE CCNE1 CDK2 CDK4 CDKN1B CDKN2 KIP1 PRAD1 PTK6 p27	Homo sapiens (human)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	GTPase HRas GTPase NRas Mast/stem cell growth factor receptor Kit Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Son of sevenless homolog 1 Tyrosine-protein kinase Fyn Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lck Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes	O00459 O60674 P01111 P01112 P06239 P06241 P07947 P07948 P10721 P27986 P40763 P42224 P42229 P42336 P51692 Q07889 Q92569	APRF FYN GRB1 HRAS HRAS1 JAK2 JTK8 KIT LCK LYN NRAS PIK3CA PIK3R1 PIK3R2 PIK3R3 SCFR SOS1 STAT1 STAT3 STAT5 STAT5A STAT5B YES YES1	Homo sapiens (human)
Collagen degradation	5-phosphohydroxy-L-lysine phospho-lyase 72 kDa type IV collagenase Cathepsin B Cathepsin D Cathepsin K Collagen alpha-1(IX) chain Collagen alpha-1(XII) chain Collagen alpha-1(XIII) chain Collagen alpha-1(XIV) chain Collagen alpha-1(XIX) chain Collagen alpha-1(XV) chain Collagen alpha-1(XVI) chain Collagen alpha-1(XVII) chain Collagen alpha-1(XVIII) chain Collagen alpha-1(XXIII) chain Collagen alpha-1(XXV) chain Collagen alpha-1(XXVI) chain Collagen alpha-2(IX) chain Collagen alpha-3(IX) chain Collagenase 3 Disintegrin and metalloproteinase domain-containing protein 10 Disintegrin and metalloproteinase domain-containing protein 17 Disintegrin and metalloproteinase domain-containing protein 9 Furin Interstitial collagenase Macrophage metalloelastase Matrilysin Matrix metalloproteinase-14 Matrix metalloproteinase-15 Matrix metalloproteinase-19 Matrix metalloproteinase-20 Matrix metalloproteinase-9 Neutrophil collagenase Neutrophil elastase Procathepsin L Stromelysin-1 Stromelysin-2 Stromelysin-3 Transmembrane protease serine 6 Trypsin-2	O14672 O60882 P03956 P07339 P07478 P07711 P07858 P08246 P08253 P08254 P09237 P09238 P09958 P14780 P20849 P22894 P24347 P39059 P39060 P39900 P43235 P45452 P50281 P51511 P78536 Q05707 Q07092 Q13443 Q14050 Q14055 Q14993 Q5TAT6 Q86Y22 Q8IU80 Q8IUZ5 Q96A83 Q99542 Q99715 Q9BXS0 Q9UMD9	ADAM10 ADAM17 ADAM9 AGXT2L2 BP180 BPAG2 CLG CLG1 CLG4A CLG4B COL12A1 COL12A1L COL13A1 COL14A1 COL15A1 COL16A1 COL17A1 COL18A1 COL19A1 COL23A1 COL25A1 COL26A1 COL9A1 COL9A2 COL9A3 CPSB CPSD CSVP CTSB CTSD CTSK CTSL CTSL1 CTSO CTSO2 ELA2 ELANE EMID2 EMU2 FUR FURIN HME KIAA0021 KUZ MADM MCMP MDC9 MLTNG MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP18 MMP19 MMP2 MMP20 MMP3 MMP7 MMP8 MMP9 MPSL1 PACE PCSK3 PHYKPL PRSS2 PUMP1 RASI STMY1 STMY2 STMY3 TACE TMPRSS6 TRY2 TRYP2 UND	Homo sapiens (human)
MicroRNA (miRNA) biogenesis	DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Endoribonuclease Dicer Exportin-5 GTP-binding nuclear protein Ran Interferon-inducible double-stranded RNA-dependent protein kinase activator A Microprocessor complex subunit DGCR8 Protein argonaute-1 Protein argonaute-2 Protein argonaute-3 Protein argonaute-4 RISC-loading complex subunit TARBP2 RNA 5'-monophosphate methyltransferase Ribonuclease 3	O15514 O75569 P19387 P19388 P24928 P30876 P36954 P52434 P52435 P53803 P61218 P62487 P62826 P62875 Q15633 Q7Z5W3 Q8WYQ5 Q9H9G7 Q9HAV4 Q9HCK5 Q9NRR4 Q9UKV8 Q9UL18 Q9UPY3	AGO1 AGO2 AGO3 AGO4 ARA24 BCDIN3D C22orf12 DGCR8 DGCRK6 DICER DICER1 DROSHA EIF2C1 EIF2C2 EIF2C3 EIF2C4 HERNA KIAA0928 KIAA1291 KIAA1567 PACT POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF PRKRA RAN RANBP21 RAX RN3 RNASE3L RNASEN RPB7 TARBP2 TRBP XPO5	Homo sapiens (human)
Role of LAT2/NTAL/LAB on calcium mobilization	3-phosphoinositide-dependent protein kinase 1 GRB2-associated-binding protein 2 IGHV7-81 protein Immunoglobulin heavy constant epsilon Immunoglobulin heavy variable 1-2 Immunoglobulin heavy variable 1-46 Immunoglobulin heavy variable 1-69 Immunoglobulin heavy variable 2-5 Immunoglobulin heavy variable 2-70 Immunoglobulin heavy variable 3-11 Immunoglobulin heavy variable 3-13 Immunoglobulin heavy variable 3-23 Immunoglobulin heavy variable 3-30 Immunoglobulin heavy variable 3-33 Immunoglobulin heavy variable 3-48 Immunoglobulin heavy variable 3-53 Immunoglobulin heavy variable 3-7 Immunoglobulin heavy variable 3-9 Immunoglobulin heavy variable 4-34 Immunoglobulin heavy variable 4-39 Immunoglobulin heavy variable 4-59 Immunoglobulin kappa constant Immunoglobulin kappa variable 1-12 Immunoglobulin kappa variable 1-16 Immunoglobulin kappa variable 1-17 Immunoglobulin kappa variable 1-33 Immunoglobulin kappa variable 1-39 Immunoglobulin kappa variable 1-5 Immunoglobulin kappa variable 1D-12 Immunoglobulin kappa variable 1D-16 Immunoglobulin kappa variable 1D-33 Immunoglobulin kappa variable 1D-39 Immunoglobulin kappa variable 2-28 Immunoglobulin kappa variable 2-29 Immunoglobulin kappa variable 2-30 Immunoglobulin kappa variable 2D-28 Immunoglobulin kappa variable 2D-30 Immunoglobulin kappa variable 2D-40 Immunoglobulin kappa variable 3-11 Immunoglobulin kappa variable 3-15 Immunoglobulin kappa variable 3-20 Immunoglobulin kappa variable 3D-20 Immunoglobulin kappa variable 4-1 Immunoglobulin kappa variable 5-2 Immunoglobulin lambda constant 1 Immunoglobulin lambda constant 2 Immunoglobulin lambda constant 3 Immunoglobulin lambda constant 6 Immunoglobulin lambda constant 7 Immunoglobulin lambda variable 1-40 Immunoglobulin lambda variable 1-44 Immunoglobulin lambda variable 1-47 Immunoglobulin lambda variable 1-51 Immunoglobulin lambda variable 2-11 Immunoglobulin lambda variable 2-14 Immunoglobulin lambda variable 2-23 Immunoglobulin lambda variable 2-8 Immunoglobulin lambda variable 3-19 Immunoglobulin lambda variable 3-1 Immunoglobulin lambda variable 3-21 Immunoglobulin lambda variable 3-25 Immunoglobulin lambda variable 3-27 Immunoglobulin lambda variable 6-57 Immunoglobulin lambda variable 7-43 Immunolglobulin kappa light chain variable region L22 (Fragment) Linker for activation of T-cells family member 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Son of sevenless homolog 1 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK UGa8H (Fragment) V1-11 protein (Fragment) V1-13 protein (Fragment) V1-16 protein (Fragment) V1-20 protein (Fragment) V1-3 protein (Fragment) V1-5 protein (Fragment) V1-7 protein (Fragment) V1-9 protein (Fragment) V2-11 protein (Fragment) V2-15 protein (Fragment) V2-17 protein (Fragment) V2-19 protein (Fragment) V2-8 protein (Fragment) V3-2 protein (Fragment) V3-3 protein (Fragment) V3-4 protein (Fragment) V4-1 protein (Fragment) V4-2 protein (Fragment) V4-6 protein (Fragment) V5-1 protein (Fragment) V5-4 protein (Fragment) V5-6 protein (Fragment)	A0A075B6P5 A0A075B6S6 A0A0C4DH25 A0A0C4DH73 A0M8Q6 A2KUC3 A2NJV5 A2NXD2 O00459 O15530 P01593 P01594 P01597 P01599 P01601 P01602 P01611 P01614 P01615 P01619 P01624 P01699 P01700 P01701 P01703 P01704 P01705 P01706 P01709 P01714 P01715 P01717 P01718 P01721 P01742 P01743 P01762 P01763 P01764 P01766 P01767 P01768 P01772 P01780 P01782 P01814 P01817 P01824 P01825 P01834 P01854 P04211 P04430 P04432 P04433 P06241 P06310 P06312 P06315 P06331 P07948 P0CF74 P0CG04 P0DOY2 P0DOY3 P23083 P27986 P42336 P42338 P43405 P80748 Q07889 Q5NV61 Q5NV62 Q5NV64 Q5NV65 Q5NV66 Q5NV67 Q5NV68 Q5NV69 Q5NV75 Q5NV79 Q5NV80 Q5NV81 Q5NV82 Q5NV83 Q5NV84 Q5NV85 Q5NV86 Q5NV87 Q5NV89 Q5NV90 Q5NV91 Q5NV92 Q6PIL0 Q9GZY6 Q9UQC2	FYN GAB2 GRB1 IGHE IGHV IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGHV7-81 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 JTK8 KIAA0571 LAB LAT2 LYN NTAL PDK1 PDPK1 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 SOS1 SYK V1-11 V1-13 V1-16 V1-20 V1-3 V1-5 V1-7 V1-9 V2-11 V2-15 V2-17 V2-19 V2-8 V3-2 V3-3 V3-4 V4-1 V4-2 V4-6 V5-1 V5-4 V5-6 WBS15 WBSCR15 WBSCR5	Homo sapiens (human)
phospho-PLA2 pathway	Cytosolic phospholipase A2 Mitogen-activated protein kinase 1	P28482 P47712	CPLA2 ERK2 MAPK1 PLA2G4 PLA2G4A PRKM1 PRKM2	Homo sapiens (human)
Signaling by kinase domain mutants of KIT	Mast/stem cell growth factor receptor Kit	P10721	KIT SCFR	Homo sapiens (human)
Histidine catabolism	Carnosine N-methyltransferase Carnosine synthase 1 Formimidoyltransferase-cyclodeaminase Histamine N-methyltransferase Histidine ammonia-lyase Histidine decarboxylase Probable imidazolonepropionase Urocanate hydratase	A5YM72 O95954 P19113 P42357 P50135 Q8N4J0 Q96N76 Q96NU7	AMDHD1 ATPGD1 C9orf41 CARNMT1 CARNS1 FTCD HAL HDC HIS HNMT KIAA1394 UROC1	Homo sapiens (human)
Signaling by FGFR2 IIIa TM	DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Fibroblast growth factor 1 Fibroblast growth factor 2 Fibroblast growth factor receptor 2 General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2	O15514 P05230 P09038 P13984 P19387 P19388 P21802 P24928 P30876 P35269 P36954 P52298 P52434 P52435 P53803 P61218 P62487 P62875 Q09161	BEK CBP20 CBP80 FGF1 FGF2 FGFA FGFB FGFR2 GTF2F1 GTF2F2 KGFR KSAM NCBP NCBP1 NCBP2 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF RAP30 RAP74 RPB7	Homo sapiens (human)
Regulation of CDH11 gene transcription	Class E basic helix-loop-helix protein 22 Forkhead box protein F1 Hairy/enhancer-of-split related with YRPW motif-like protein Homeobox protein Hox-C8 Interleukin enhancer-binding factor 3 PR domain zinc finger protein 8 Transcription factor Sp1 Zinc finger E-box-binding homeobox 2 Zinc finger protein SNAI1	O60315 O95863 P08047 P31273 Q12906 Q12946 Q8NFJ8 Q9NQ87 Q9NQV8	BHLHB33 BHLHB5 BHLHE22 DRBF FKHL5 FOXF1 FREAC1 HEYL HOX3A HOXC8 HRT3 ILF3 KIAA0569 MPHOSPH4 NF90 PFM5 PRDM8 SIP1 SNAH SNAI1 SP1 TNRC20 TSFP1 ZEB2 ZFHX1B ZFX1B	Homo sapiens (human)
Biosynthesis of maresin-like SPMs	Cytochrome P450 1A2 Cytochrome P450 2C8 Cytochrome P450 2C9 Cytochrome P450 2D6 Cytochrome P450 2E1 Cytochrome P450 3A4	P05177 P05181 P08684 P10632 P10635 P11712	CYP1A2 CYP2C10 CYP2C8 CYP2C9 CYP2D6 CYP2DL1 CYP2E CYP2E1 CYP3A3 CYP3A4	Homo sapiens (human)
Defective visual phototransduction due to OPN1LW loss of function	Long-wave-sensitive opsin 1	P04000	OPN1LW RCP	Homo sapiens (human)
MET activates STAT3	Hepatocyte growth factor receptor Hepatocyte growth factor Signal transducer and activator of transcription 3	P08581 P14210 P40763	APRF HGF HPTA MET STAT3	Homo sapiens (human)
EGFR Transactivation by Gastrin	Epidermal growth factor receptor GTPase HRas GTPase NRas Proheparin-binding EGF-like growth factor Protein kinase C alpha type Son of sevenless homolog 1 Stromelysin-1	P00533 P01111 P01112 P08254 P17252 Q07889 Q99075	DTR DTS EGFR ERBB ERBB1 HBEGF HEGFL HER1 HRAS HRAS1 MMP3 NRAS PKCA PRKACA PRKCA SOS1 STMY1	Homo sapiens (human)
Activation of NOXA and translocation to mitochondria	Cellular tumor antigen p53 Phorbol-12-myristate-13-acetate-induced protein 1 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1	P04637 Q01094 Q13794 Q14186 Q14188	DP1 DP2 E2F1 NOXA P53 PMAIP1 RBBP3 TFDP1 TFDP2 TP53	Homo sapiens (human)
Inactivation of CSF3 (G-CSF) signaling	Cullin-5 Elongin-B Elongin-C Granulocyte colony-stimulating factor receptor Granulocyte colony-stimulating factor Non-receptor tyrosine-protein kinase TYK2 Polyubiquitin-B Polyubiquitin-C RING-box protein 2 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase HCK Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14543 O15524 O60674 P07948 P08631 P09919 P0CG47 P0CG48 P23458 P29597 P40763 P42224 P42229 P43405 P51668 P51692 P61077 P62837 P62979 P62987 Q15369 Q15370 Q93034 Q99062 Q9UBF6	APRF C17orf33 CIS3 CSF3 CSF3R CUL5 ELOB ELOC GCSF GCSFR HCK JAK1 JAK1A JAK1B JAK2 JTK8 LYN PUBC1 RBX2 RNF7 ROC2 RPS27A SAG SFT SOCS1 SOCS3 SSI1 SSI3 STAT1 STAT3 STAT5 STAT5A STAT5B SYK TCEB1 TCEB2 TIP3 TYK2 UBA52 UBA80 UBB UBC UBC4 UBC5A UBC5B UBC5C UBCEP1 UBCEP2 UBCH4 UBCH5 UBCH5A UBCH5B UBCH5C UBE2D1 UBE2D2 UBE2D3 VACM1	Homo sapiens (human)
mRNA Capping	CDK-activating kinase assembly factor MAT1 Cyclin-H Cyclin-dependent kinase 7 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Transcription elongation factor SPT5 mRNA cap guanine-N7 methyltransferase mRNA-capping enzyme	O00267 O15514 O43148 O60942 P13984 P18074 P19387 P19388 P19447 P24928 P30876 P32780 P35269 P36954 P50613 P51946 P51948 P52298 P52434 P52435 P53803 P61218 P62487 P62875 Q09161 Q13888 Q13889 Q6ZYL4 Q92759	BTF2 BTF2P44 C6orf175 CAK CAK1 CAP1A CAP35 CBP20 CBP80 CCNH CDK7 CDKN7 ERCC2 ERCC3 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 KIAA0398 MAT1 MNAT1 MO15 NCBP NCBP1 NCBP2 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF RAP30 RAP74 RNF66 RNGTT RNMT RPB7 SPT5 SPT5H STK1 SUPT5H TTDA XPB XPBC XPD XPDC	Homo sapiens (human)

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