GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **351 - 375** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Sorafenib-resistant KIT mutants	Mast/stem cell growth factor receptor Kit	P10721	KIT SCFR	Homo sapiens (human)
TP53 Regulates Transcription of Caspase Activators and Caspases	Apoptotic protease-activating factor 1 Caspase-10 Caspase-1 Caspase-2 Caspase-6 Cellular tumor antigen p53 Death domain-containing protein CRADD NLR family CARD domain-containing protein 4 Serine-protein kinase ATM Tumor protein 63 Tumor protein p73 p53-induced death domain-containing protein 1	O14727 O15350 P04637 P29466 P42575 P55212 P78560 Q13315 Q92851 Q9H3D4 Q9HB75 Q9NPP4	APAF1 ATM CARD12 CASP1 CASP10 CASP2 CASP6 CLAN CLAN1 CRADD ICH1 IL1BC IL1BCE IPAF KET KIAA0413 LRDD MCH2 MCH4 NEDD2 NLRC4 P53 P63 P73 P73H P73L PIDD PIDD1 RAIDD TP53 TP63 TP73 TP73L	Homo sapiens (human)
RAB GEFs exchange GTP for GDP on RABs	14-3-3 protein epsilon ALS2 C-terminal-like protein Alsin Ankyrin repeat domain-containing protein 27 BLOC-3 complex member HPS1 BLOC-3 complex member HPS4 C-myc promoter-binding protein DENN domain-containing protein 1A DENN domain-containing protein 1B DENN domain-containing protein 1C DENN domain-containing protein 2A DENN domain-containing protein 2B DENN domain-containing protein 2C DENN domain-containing protein 2D DENN domain-containing protein 3 DENN domain-containing protein 4B DENN domain-containing protein 4C DENN domain-containing protein 5A DENN domain-containing protein 5B GTPase-activating protein and VPS9 domain-containing protein 1 Guanine nucleotide exchange factor for Rab-3A Guanine nucleotide exchange factor subunit RIC1 Myotubularin-related protein 13 Myotubularin-related protein 5 Protein DENND6A Protein DENND6B RAB6A-GEF complex partner protein 2 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rab GDP dissociation inhibitor alpha Rab GDP dissociation inhibitor beta Rab proteins geranylgeranyltransferase component A 1 Rab proteins geranylgeranyltransferase component A 2 Rab-3A-interacting protein Rab3 GTPase-activating protein catalytic subunit Rab3 GTPase-activating protein non-catalytic subunit Rab5 GDP/GTP exchange factor Ras and Rab interactor 1 Ras and Rab interactor 2 Ras and Rab interactor 3 Ras and Rab interactor-like protein Ras-related protein Rab-10 Ras-related protein Rab-12 Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-18 Ras-related protein Rab-1A Ras-related protein Rab-1B Ras-related protein Rab-21 Ras-related protein Rab-27A Ras-related protein Rab-27B Ras-related protein Rab-31 Ras-related protein Rab-32 Ras-related protein Rab-35 Ras-related protein Rab-38 Ras-related protein Rab-39A Ras-related protein Rab-39B Ras-related protein Rab-3A Ras-related protein Rab-5A Ras-related protein Rab-5B Ras-related protein Rab-5C Ras-related protein Rab-6A Ras-related protein Rab-6B Ras-related protein Rab-7a Ras-related protein Rab-7b Ras-related protein Rab-8A Ras-related protein Rab-8B Ras-related protein Rab-9A Ras-related protein Rab-9B Serine/threonine-protein kinase ULK1 Trafficking protein particle complex subunit 10 Trafficking protein particle complex subunit 11 Trafficking protein particle complex subunit 12 Trafficking protein particle complex subunit 13 Trafficking protein particle complex subunit 1 Trafficking protein particle complex subunit 2-like protein Trafficking protein particle complex subunit 2 Trafficking protein particle complex subunit 3 Trafficking protein particle complex subunit 4 Trafficking protein particle complex subunit 5 Trafficking protein particle complex subunit 6A Trafficking protein particle complex subunit 6B Trafficking protein particle complex subunit 8 Trafficking protein particle complex subunit 9 Vacuolar fusion protein CCZ1 homolog B Vacuolar fusion protein CCZ1 homolog Vacuolar fusion protein MON1 homolog A Vacuolar fusion protein MON1 homolog B	A2RUS2 A5PLN9 O00194 O43617 O75064 O75385 O75865 O95248 P0DI81 P20336 P20339 P20340 P24386 P26374 P31150 P31749 P31751 P48553 P50395 P51148 P51149 P51151 P51153 P51159 P57729 P61006 P61020 P61026 P61106 P62258 P62820 P78524 P86790 P86791 Q13636 Q13637 Q13671 Q14964 Q14C86 Q15042 Q15286 Q4ADV7 Q5VZ89 Q60I27 Q68D51 Q6IQ22 Q6IQ26 Q6P3S1 Q6ZS11 Q6ZUT9 Q7L1V2 Q7Z392 Q7Z401 Q86SZ2 Q86VX9 Q86WG5 Q8IUR0 Q8IV53 Q8IWF6 Q8NEG7 Q8TB24 Q8TBN0 Q8TEH3 Q8WVT3 Q8WYP3 Q92546 Q92902 Q92930 Q96AH8 Q96DA2 Q96NW4 Q96Q05 Q96Q42 Q96QF0 Q9H0U4 Q9H2M9 Q9H6A0 Q9NP72 Q9NP90 Q9NQG7 Q9NRW1 Q9UJ41 Q9UL25 Q9UL33 Q9ULE3 Q9Y243 Q9Y296 Q9Y2L5 Q9Y5R8	AKT1 AKT2 AKT3 ALS2 ALS2CL ALS2CR6 ANKRD27 BET3 BET5 C1orf218 C4orf41 C5orf44 C7orf28A C7orf28B C9orf55 C9orf55B CCZ1 CCZ1B CHM CHML CIP150 CMT4B2 DENND1A DENND1B DENND1C DENND2A DENND2B DENND2C DENND2D DENND3 DENND4A DENND4B DENND4C DENND5A DENND5B DENND6A DENND6B EHOC1 FAM116A FAM116B FAM31A FAM31B FAM31C GAPEX5 GAPVD1 GDI1 GDI2 GDIL HPS HPS1 HPS4 HSRG1 HTS1 IRLB KIAA0066 KIAA0118 KIAA0258 KIAA0476 KIAA0722 KIAA0839 KIAA0870 KIAA0872 KIAA1012 KIAA1091 KIAA1277 KIAA1432 KIAA1521 KIAA1563 KIAA1608 KIAA1667 KIAA1766 KIAA1882 MEL MON1A MON1B MTMR13 MTMR5 MUM2 MYCPBP NIBP OPHN2 PKB PKBG RAB1 RAB10 RAB12 RAB13 RAB14 RAB18 RAB1A RAB1B RAB1C RAB21 RAB22B RAB27 RAB27A RAB27B RAB31 RAB32 RAB35 RAB38 RAB39 RAB39A RAB39B RAB3A RAB3GAP RAB3GAP1 RAB3GAP2 RAB3IL1 RAB3IP RAB5 RAB5A RAB5B RAB5C RAB6 RAB6A RAB6B RAB6IP1 RAB7 RAB7A RAB7B RAB8 RAB8A RAB8B RAB9 RAB9A RAB9B RAB9L RABEX5 RABGDIA RABGDIB RABGEF1 RABIN8 RABL RAC RAP6 RASSF4 RAY REP1 REP2 RGP1 RIC1 RIN1 RIN2 RIN3 RINL SAND1 SAND2 SBDN SBF1 SBF2 SEDL ST5 TCD TMEM1 TRAMM TRAPPC1 TRAPPC10 TRAPPC11 TRAPPC12 TRAPPC13 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC4 TRAPPC5 TRAPPC6A TRAPPC6B TRAPPC8 TRAPPC9 TTC15 ULK1 XAP4 YWHAE	Homo sapiens (human)
RSK activation	3-phosphoinositide-dependent protein kinase 1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Ribosomal protein S6 kinase alpha-1 Ribosomal protein S6 kinase alpha-2 Ribosomal protein S6 kinase alpha-3 Ribosomal protein S6 kinase alpha-6	O15530 P27361 P28482 P51812 Q15349 Q15418 Q9UK32	ERK1 ERK2 ISPK1 MAPK1 MAPK3 MAPKAPK1A MAPKAPK1B MAPKAPK1C PDK1 PDPK1 PRKM1 PRKM2 PRKM3 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 RSK1 RSK2 RSK3 RSK4	Homo sapiens (human)
RNA Polymerase I Promoter Escape	CDK-activating kinase assembly factor MAT1 Chromobox protein homolog 3 Cyclin-H Cyclin-dependent kinase 7 DNA-directed RNA polymerase I subunit RPA12 DNA-directed RNA polymerase I subunit RPA1 DNA-directed RNA polymerase I subunit RPA2 DNA-directed RNA polymerase I subunit RPA34 DNA-directed RNA polymerase I subunit RPA43 DNA-directed RNA polymerase I subunit RPA49 DNA-directed RNA polymerases I and III subunit RPAC1 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Nucleolar transcription factor 1 Protein POLR1D, isoform 2 RNA polymerase I-specific transcription initiation factor RRN3 TATA box-binding protein-associated factor RNA polymerase I subunit A TATA box-binding protein-associated factor RNA polymerase I subunit B TATA box-binding protein-associated factor RNA polymerase I subunit C TATA box-binding protein-associated factor RNA polymerase I subunit D TATA-box-binding protein	O15160 O15446 O60814 O95602 P04908 P06899 P0C5Y9 P0DPB5 P16104 P17480 P18074 P19388 P19447 P20226 P20671 P23527 P32780 P33778 P50613 P51946 P51948 P52434 P53803 P57053 P58876 P61218 P62805 P62807 P62875 P68431 P84243 Q13185 Q13888 Q13889 Q15572 Q15573 Q16777 Q16778 Q3B726 Q53T94 Q6FI13 Q6ZYL4 Q71DI3 Q71UI9 Q8N257 Q92759 Q93077 Q93079 Q96A08 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9GZS1 Q9H5J8 Q9H9Y6 Q9NYV6 Q9P1U0	ASE1 BTF2 BTF2P44 C6orf175 CAK CAK1 CAP35 CAST CBX3 CCNH CD3EAP CDK7 CDKN7 ERCC2 ERCC3 GTF2D1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 JOSD3 MAT1 MNAT1 MO15 PAF49 PAF53 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L POLRF PRAF1 RNF66 RPA12 RRN3 STK1 TAF1A TAF1B TAF1C TAF1D TBP TF2D TFIID TIFIA TSH2B TTDA TWISTNB UBF UBF1 UBTF XPB XPBC XPD XPDC ZNRD1	Homo sapiens (human)
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	Complement component 1 Q subcomponent-binding protein, mitochondrial Tumor suppressor ARF	Q07021 Q8N726	C1QBP CDKN2 CDKN2A GC1QBP HABP1 MLM SF2P32	Homo sapiens (human)
CRMPs in Sema3A signaling	Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 Dihydropyrimidinase-related protein 1 Dihydropyrimidinase-related protein 2 Dihydropyrimidinase-related protein 3 Dihydropyrimidinase-related protein 4 Dihydropyrimidinase-related protein 5 Glycogen synthase kinase-3 beta Neuropilin-1 Plexin-A1 Plexin-A2 Plexin-A3 Plexin-A4 Semaphorin-3A Tyrosine-protein kinase Fes/Fps Tyrosine-protein kinase Fyn	O14531 O14786 O75051 P06241 P07332 P49841 P51805 Q00535 Q14194 Q14195 Q14563 Q15078 Q16555 Q9BPU6 Q9HCM2 Q9UIW2	CDK5 CDK5R CDK5R1 CDKN5 CRMP1 CRMP2 CRMP3 CRMP4 CRMP5 DPYSL1 DPYSL2 DPYSL3 DPYSL4 DPYSL5 DRP3 FES FPS FYN GSK3B KIAA0463 KIAA1550 NCK5A NOV NRP NRP1 OCT PLXN1 PLXN2 PLXN4 PLXNA1 PLXNA2 PLXNA3 PLXNA4 PLXNA4A PLXNA4B PSSALRE SEMA3A SEMAD SEX ULIP ULIP1 ULIP2 ULIP3 ULIP4 ULIP6 VEGF165R	Homo sapiens (human)
Regulation of Complement cascade	B-lymphocyte antigen CD19 C3a anaphylatoxin chemotactic receptor C4b-binding protein alpha chain C4b-binding protein beta chain C5a anaphylatoxin chemotactic receptor 1 C5a anaphylatoxin chemotactic receptor 2 CD59 glycoprotein CD81 antigen Carboxypeptidase B2 Carboxypeptidase N catalytic chain Carboxypeptidase N subunit 2 Clusterin Complement C1q subcomponent subunit A Complement C1q subcomponent subunit B Complement C1q subcomponent subunit C Complement C1r subcomponent Complement C1s subcomponent Complement C2 Complement C3 Complement C4-A Complement C4-B Complement C5 Complement component C6 Complement component C7 Complement component C8 alpha chain Complement component C8 beta chain Complement component C8 gamma chain Complement component C9 Complement decay-accelerating factor Complement factor B Complement factor H-related protein 1 Complement factor H-related protein 2 Complement factor H-related protein 3 Complement factor H-related protein 4 Complement factor H-related protein 5 Complement factor H Complement factor I Complement receptor type 1 Complement receptor type 2 IGHV7-81 protein Immunoglobulin heavy constant gamma 1 Immunoglobulin heavy constant gamma 2 Immunoglobulin heavy constant gamma 3 Immunoglobulin heavy constant gamma 4 Immunoglobulin heavy variable 1-2 Immunoglobulin heavy variable 1-46 Immunoglobulin heavy variable 1-69 Immunoglobulin heavy variable 2-5 Immunoglobulin heavy variable 2-70 Immunoglobulin heavy variable 3-11 Immunoglobulin heavy variable 3-13 Immunoglobulin heavy variable 3-23 Immunoglobulin heavy variable 3-30 Immunoglobulin heavy variable 3-33 Immunoglobulin heavy variable 3-48 Immunoglobulin heavy variable 3-53 Immunoglobulin heavy variable 3-7 Immunoglobulin heavy variable 3-9 Immunoglobulin heavy variable 4-34 Immunoglobulin heavy variable 4-39 Immunoglobulin heavy variable 4-59 Immunoglobulin kappa constant Immunoglobulin kappa variable 1-12 Immunoglobulin kappa variable 1-16 Immunoglobulin kappa variable 1-17 Immunoglobulin kappa variable 1-33 Immunoglobulin kappa variable 1-39 Immunoglobulin kappa variable 1-5 Immunoglobulin kappa variable 1D-12 Immunoglobulin kappa variable 1D-16 Immunoglobulin kappa variable 1D-33 Immunoglobulin kappa variable 1D-39 Immunoglobulin kappa variable 2-28 Immunoglobulin kappa variable 2-29 Immunoglobulin kappa variable 2-30 Immunoglobulin kappa variable 2D-28 Immunoglobulin kappa variable 2D-30 Immunoglobulin kappa variable 2D-40 Immunoglobulin kappa variable 3-11 Immunoglobulin kappa variable 3-15 Immunoglobulin kappa variable 3-20 Immunoglobulin kappa variable 3D-20 Immunoglobulin kappa variable 4-1 Immunoglobulin kappa variable 5-2 Immunoglobulin lambda constant 1 Immunoglobulin lambda constant 2 Immunoglobulin lambda constant 3 Immunoglobulin lambda constant 6 Immunoglobulin lambda constant 7 Immunoglobulin lambda variable 1-40 Immunoglobulin lambda variable 1-44 Immunoglobulin lambda variable 1-47 Immunoglobulin lambda variable 1-51 Immunoglobulin lambda variable 2-11 Immunoglobulin lambda variable 2-14 Immunoglobulin lambda variable 2-23 Immunoglobulin lambda variable 2-8 Immunoglobulin lambda variable 3-19 Immunoglobulin lambda variable 3-1 Immunoglobulin lambda variable 3-21 Immunoglobulin lambda variable 3-25 Immunoglobulin lambda variable 3-27 Immunoglobulin lambda variable 6-57 Immunoglobulin lambda variable 7-43 Immunolglobulin kappa light chain variable region L22 (Fragment) Membrane cofactor protein Neutrophil elastase Plasma protease C1 inhibitor Prothrombin UGa8H (Fragment) V1-11 protein (Fragment) V1-13 protein (Fragment) V1-16 protein (Fragment) V1-20 protein (Fragment) V1-3 protein (Fragment) V1-5 protein (Fragment) V1-7 protein (Fragment) V1-9 protein (Fragment) V2-11 protein (Fragment) V2-15 protein (Fragment) V2-17 protein (Fragment) V2-19 protein (Fragment) V2-8 protein (Fragment) V3-2 protein (Fragment) V3-3 protein (Fragment) V3-4 protein (Fragment) V4-1 protein (Fragment) V4-2 protein (Fragment) V4-6 protein (Fragment) V5-1 protein (Fragment) V5-4 protein (Fragment) V5-6 protein (Fragment) Vitamin K-dependent protein S Vitronectin	A0A075B6P5 A0A075B6S6 A0A0C4DH25 A0A0C4DH73 A0M8Q6 A2KUC3 A2NJV5 A2NXD2 P00734 P00736 P00751 P01024 P01031 P01593 P01594 P01597 P01599 P01601 P01602 P01611 P01614 P01615 P01619 P01624 P01699 P01700 P01701 P01703 P01704 P01705 P01706 P01709 P01714 P01715 P01717 P01718 P01721 P01742 P01743 P01762 P01763 P01764 P01766 P01767 P01768 P01772 P01780 P01782 P01814 P01817 P01824 P01825 P01834 P01857 P01859 P01860 P01861 P02745 P02746 P02747 P02748 P04003 P04004 P04211 P04430 P04432 P04433 P05155 P05156 P06310 P06312 P06315 P06331 P06681 P07225 P07357 P07358 P07360 P08174 P08246 P08603 P09871 P0C0L4 P0C0L5 P0CF74 P0CG04 P0DOY2 P0DOY3 P10643 P10909 P13671 P13987 P15169 P15391 P15529 P17927 P20023 P20851 P21730 P22792 P23083 P36980 P60033 P80748 Q02985 Q03591 Q16581 Q5NV61 Q5NV62 Q5NV64 Q5NV65 Q5NV66 Q5NV67 Q5NV68 Q5NV69 Q5NV75 Q5NV79 Q5NV80 Q5NV81 Q5NV82 Q5NV83 Q5NV84 Q5NV85 Q5NV86 Q5NV87 Q5NV89 Q5NV90 Q5NV91 Q5NV92 Q6PIL0 Q92496 Q96IY4 Q9BXR6 Q9P296	ACBP APOJ AZ3B BF BFD C1IN C1NH C1QA C1QB C1QC C1QG C1R C1S C2 C3 C3AR1 C3BR C3DR C3R1 C4A C4B C4BP C4BPA C4BPB C4B_2 C5 C5AR C5AR1 C5AR2 C5L2 C5R1 C6 C7 C8A C8B C8G C9 CD19 CD46 CD55 CD59 CD81 CFB CFH CFHL CFHL1 CFHL1P CFHL2 CFHL3 CFHL4 CFHL5 CFHR1 CFHR1P CFHR2 CFHR3 CFHR4 CFHR5 CFI CLI CLU CO4 CPAMD1 CPAMD2 CPAMD3 CPAMD4 CPB2 CPN1 CPN2 CR CR1 CR2 DAF ELA2 ELANE F2 FHR1 FHR2 FHR3 FHR4 FHR5 GPR77 HF HF1 HF2 HFL1 HFL2 HFL3 HNFAG09 IF IGHG1 IGHG2 IGHG3 IGHG4 IGHV IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGHV7-81 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 KUB1 MCP MIC10 MIC11 MIN1 MIN2 MIN3 MSK21 PROS PROS1 SERPING1 TAPA1 TSPAN28 V1-11 V1-13 V1-16 V1-20 V1-3 V1-5 V1-7 V1-9 V2-11 V2-15 V2-17 V2-19 V2-8 V3-2 V3-3 V3-4 V4-1 V4-2 V4-6 V5-1 V5-4 V5-6 VTN	Homo sapiens (human)
Polymerase switching on the C-strand of the telomere	Adrenocortical dysplasia protein homolog CST complex subunit CTC1 CST complex subunit STN1 CST complex subunit TEN1 Chromosome transmission fidelity protein 18 homolog Chromosome transmission fidelity protein 8 homolog DNA polymerase alpha catalytic subunit DNA polymerase alpha subunit B DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA primase large subunit DNA primase small subunit Proliferating cell nuclear antigen Protection of telomeres protein 1 Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Sister chromatid cohesion protein DCC1 TERF1-interacting nuclear factor 2 Telomeric repeat-binding factor 1 Telomeric repeat-binding factor 2-interacting protein 1 Telomeric repeat-binding factor 2	P09884 P0CG13 P12004 P28340 P35249 P35250 P35251 P40937 P40938 P49005 P49642 P49643 P54274 Q14181 Q15054 Q15554 Q2NKJ3 Q86WV5 Q8WVB6 Q96AP0 Q9BSI4 Q9BVC3 Q9H668 Q9HCU8 Q9NUX5 Q9NYB0	ACD C16orf41 C17orf106 C17orf68 CHTF18 CHTF8 CTC1 CTF18 CTF8 DCC1 DRIP5 DSCC1 KIAA0039 OBFC1 PCNA PIN2 PIP1 POLA POLA1 POLA2 POLD POLD1 POLD2 POLD3 POLD4 POLDS POT1 PRIM1 PRIM2 PRIM2A PTOP RAP1 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 STN1 TEN1 TERF1 TERF2 TERF2IP TIN2 TINF2 TINT1 TPP1 TRBF1 TRBF2 TRF TRF1 TRF2	Homo sapiens (human)
Interaction With Cumulus Cells And The Zona Pellucida	Beta-1,4-galactosyltransferase 1 Disintegrin and metalloproteinase domain-containing protein 20 Disintegrin and metalloproteinase domain-containing protein 21 Disintegrin and metalloproteinase domain-containing protein 2 Disintegrin and metalloproteinase domain-containing protein 30 Hyaluronidase PH-20 Oviduct-specific glycoprotein Zona pellucida sperm-binding protein 1 Zona pellucida sperm-binding protein 2 Zona pellucida sperm-binding protein 3 Zona pellucida sperm-binding protein 4	O43506 P15291 P21754 P38567 P60852 Q05996 Q12836 Q12889 Q99965 Q9UKF2 Q9UKJ8	ADAM2 ADAM20 ADAM21 ADAM30 B4GALT1 FTNB GGTB2 HYAL3 MUC9 OGP OVGP1 PH20 SPAM1 ZP1 ZP2 ZP3 ZP3A ZP3B ZP4 ZPA ZPB ZPC	Homo sapiens (human)
FCGR3A-mediated IL10 synthesis	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Adenylate cyclase type 1 Adenylate cyclase type 2 Adenylate cyclase type 3 Adenylate cyclase type 4 Adenylate cyclase type 5 Adenylate cyclase type 6 Adenylate cyclase type 7 Adenylate cyclase type 8 Adenylate cyclase type 9 Calmodulin-1 High affinity immunoglobulin gamma Fc receptor I IGHV7-81 protein Immunoglobulin heavy constant gamma 1 Immunoglobulin heavy constant gamma 2 Immunoglobulin heavy constant gamma 3 Immunoglobulin heavy constant gamma 4 Immunoglobulin heavy variable 1-2 Immunoglobulin heavy variable 1-46 Immunoglobulin heavy variable 1-69 Immunoglobulin heavy variable 2-5 Immunoglobulin heavy variable 2-70 Immunoglobulin heavy variable 3-11 Immunoglobulin heavy variable 3-13 Immunoglobulin heavy variable 3-23 Immunoglobulin heavy variable 3-30 Immunoglobulin heavy variable 3-33 Immunoglobulin heavy variable 3-48 Immunoglobulin heavy variable 3-53 Immunoglobulin heavy variable 3-7 Immunoglobulin heavy variable 3-9 Immunoglobulin heavy variable 4-34 Immunoglobulin heavy variable 4-39 Immunoglobulin heavy variable 4-59 Immunoglobulin kappa constant Immunoglobulin kappa variable 1-12 Immunoglobulin kappa variable 1-16 Immunoglobulin kappa variable 1-17 Immunoglobulin kappa variable 1-33 Immunoglobulin kappa variable 1-39 Immunoglobulin kappa variable 1-5 Immunoglobulin kappa variable 1D-12 Immunoglobulin kappa variable 1D-16 Immunoglobulin kappa variable 1D-33 Immunoglobulin kappa variable 1D-39 Immunoglobulin kappa variable 2-28 Immunoglobulin kappa variable 2-29 Immunoglobulin kappa variable 2-30 Immunoglobulin kappa variable 2D-28 Immunoglobulin kappa variable 2D-30 Immunoglobulin kappa variable 2D-40 Immunoglobulin kappa variable 3-11 Immunoglobulin kappa variable 3-15 Immunoglobulin kappa variable 3-20 Immunoglobulin kappa variable 3D-20 Immunoglobulin kappa variable 4-1 Immunoglobulin kappa variable 5-2 Immunoglobulin lambda constant 1 Immunoglobulin lambda constant 2 Immunoglobulin lambda constant 3 Immunoglobulin lambda constant 6 Immunoglobulin lambda constant 7 Immunoglobulin lambda variable 1-40 Immunoglobulin lambda variable 1-44 Immunoglobulin lambda variable 1-47 Immunoglobulin lambda variable 1-51 Immunoglobulin lambda variable 2-11 Immunoglobulin lambda variable 2-14 Immunoglobulin lambda variable 2-23 Immunoglobulin lambda variable 2-8 Immunoglobulin lambda variable 3-19 Immunoglobulin lambda variable 3-1 Immunoglobulin lambda variable 3-21 Immunoglobulin lambda variable 3-25 Immunoglobulin lambda variable 3-27 Immunoglobulin lambda variable 6-57 Immunoglobulin lambda variable 7-43 Immunolglobulin kappa light chain variable region L22 (Fragment) Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 Interleukin-10 Low affinity immunoglobulin gamma Fc region receptor II-a Low affinity immunoglobulin gamma Fc region receptor III-A Putative GIPL galf transferase S-adenosylhomocysteine hydrolase-like protein 1 T-cell surface glycoprotein CD3 gamma chain Tyrosine-protein kinase Fgr Tyrosine-protein kinase Fyn Tyrosine-protein kinase HCK Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK Tyrosine-protein kinase Yes UGa8H (Fragment) V1-11 protein (Fragment) V1-13 protein (Fragment) V1-16 protein (Fragment) V1-20 protein (Fragment) V1-3 protein (Fragment) V1-5 protein (Fragment) V1-7 protein (Fragment) V1-9 protein (Fragment) V2-11 protein (Fragment) V2-15 protein (Fragment) V2-17 protein (Fragment) V2-19 protein (Fragment) V2-8 protein (Fragment) V3-2 protein (Fragment) V3-3 protein (Fragment) V3-4 protein (Fragment) V4-1 protein (Fragment) V4-2 protein (Fragment) V4-6 protein (Fragment) V5-1 protein (Fragment) V5-4 protein (Fragment) V5-6 protein (Fragment) cAMP-dependent protein kinase catalytic subunit PRKX cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit	A0A075B6P5 A0A075B6S6 A0A0C4DH25 A0A0C4DH73 A0M8Q6 A2KUC3 A2NJV5 A2NXD2 O43306 O43865 O60266 O60503 O95622 P01593 P01594 P01597 P01599 P01601 P01602 P01611 P01614 P01615 P01619 P01624 P01699 P01700 P01701 P01703 P01704 P01705 P01706 P01709 P01714 P01715 P01717 P01718 P01721 P01742 P01743 P01762 P01763 P01764 P01766 P01767 P01768 P01772 P01780 P01782 P01814 P01817 P01824 P01825 P01834 P01857 P01859 P01860 P01861 P04211 P04430 P04432 P04433 P06241 P06310 P06312 P06315 P06331 P07947 P07948 P08631 P08637 P09693 P09769 P0CF74 P0CG04 P0DOY2 P0DOY3 P0DP23 P10644 P12314 P12318 P13861 P16885 P17612 P19174 P22301 P22612 P22694 P23083 P31321 P31323 P40145 P43405 P51817 P51828 P80748 Q08462 Q08828 Q14571 Q14573 Q14643 Q4QD44 Q5NV61 Q5NV62 Q5NV64 Q5NV65 Q5NV66 Q5NV67 Q5NV68 Q5NV69 Q5NV75 Q5NV79 Q5NV80 Q5NV81 Q5NV82 Q5NV83 Q5NV84 Q5NV85 Q5NV86 Q5NV87 Q5NV89 Q5NV90 Q5NV91 Q5NV92 Q6PIL0 Q8NFM4	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AHCYL1 CALM CALM1 CAM CAM1 CD16A CD32 CD3G DCAL FCG1 FCG2 FCG3 FCGR1 FCGR1A FCGR2A FCGR2A1 FCGR3 FCGR3A FGR FYN HCK IGFR1 IGFR2 IGFR3 IGHG1 IGHG2 IGHG3 IGHG4 IGHV IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGHV7-81 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 IL10 INSP3R1 IRBIT ITPR1 ITPR2 ITPR3 JTK8 KIAA0037 KIAA0422 KIAA0511 KIAA0520 KIAA1060 LPG1G LPG1G2 LYN PKACA PKR1 PKR2 PKX1 PLC1 PLCG1 PLCG2 PRKACA PRKACB PRKACG PRKAR1 PRKAR1A PRKAR1B PRKAR2 PRKAR2A PRKAR2B PRKX SRC2 SYK T3G TSE1 V1-11 V1-13 V1-16 V1-20 V1-3 V1-5 V1-7 V1-9 V2-11 V2-15 V2-17 V2-19 V2-8 V3-2 V3-3 V3-4 V4-1 V4-2 V4-6 V5-1 V5-4 V5-6 XPVKONA YES YES1	Homo sapiens (human)
Inhibition of membrane repair	ESAT-6-like protein EsxG ESAT-6-like protein EsxH Hepatocyte growth factor-regulated tyrosine kinase substrate	O14964 O53692 P9WNK3	HGS HRS cfp7 esxG esxH	Homo sapiens (human)
LGI-ADAM interactions	Disintegrin and metalloproteinase domain-containing protein 11 Disintegrin and metalloproteinase domain-containing protein 22 Disintegrin and metalloproteinase domain-containing protein 23 Disks large homolog 4 Leucine-rich glioma-inactivated protein 1 Leucine-rich repeat LGI family member 2 Leucine-rich repeat LGI family member 3 Leucine-rich repeat LGI family member 4 Syntaxin-1A Syntaxin-1B Voltage-dependent calcium channel gamma-2 subunit Voltage-dependent calcium channel gamma-3 subunit Voltage-dependent calcium channel gamma-4 subunit Voltage-dependent calcium channel gamma-8 subunit	O60359 O75077 O75078 O95970 P61266 P78352 Q16623 Q8N0V4 Q8N135 Q8N145 Q8WXS5 Q9P0K1 Q9UBN1 Q9Y698	ADAM11 ADAM22 ADAM23 CACNG2 CACNG3 CACNG4 CACNG6 CACNG8 DLG4 EPT KIAA1916 LGI1 LGI2 LGI3 LGI4 LGIL2 LGIL3 LGIL4 MDC MDC2 MDC3 PSD95 STX1 STX1A STX1B STX1B1 STX1B2	Homo sapiens (human)
Transport of inorganic cations/anions and amino acids/oligopeptides	Cystinosin Excitatory amino acid transporter 1 Excitatory amino acid transporter 2 Excitatory amino acid transporter 3 Excitatory amino acid transporter 4 Excitatory amino acid transporter 5 Mitochondrial S-adenosylmethionine carrier protein Vesicular inhibitory amino acid transporter	O00341 O60931 P43003 P43004 P43005 P48664 Q70HW3 Q9H598	CTNS EAAC1 EAAT1 EAAT2 EAAT3 EAAT4 EAAT5 GLAST GLAST1 GLT1 HEAAC1 SAMC SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 SLC25A26 SLC32A1 VGAT VIAAT	Homo sapiens (human)
CLEC7A/inflammasome pathway	Apoptosis-associated speck-like protein containing a CARD Caspase-8 Interleukin-1 beta Mucosa-associated lymphoid tissue lymphoma translocation protein 1 Nuclear factor NF-kappa-B p105 subunit Transcription factor p65	P01584 P19838 Q04206 Q14790 Q9UDY8 Q9ULZ3	ASC CARD5 CASP8 IL1B IL1F2 MALT1 MCH5 MLT NFKB1 NFKB3 PYCARD RELA TMS1	Homo sapiens (human)
Rhesus glycoproteins mediate ammonium transport	Ammonium transporter Rh type A Ammonium transporter Rh type B Ammonium transporter Rh type C	Q02094 Q9H310 Q9UBD6	C15orf6 CDRC2 PDRC2 RH50 RHAG RHBG RHCG RHGK	Homo sapiens (human)
Signaling by LTK in cancer	CAP-Gly domain-containing linker protein 1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O00459 P27361 P27986 P28482 P30622 P42336 P42338	CLIP1 CYLN1 ERK1 ERK2 GRB1 MAPK1 MAPK3 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PRKM1 PRKM2 PRKM3 RSN	Homo sapiens (human)
Relaxin receptors	Insulin-like 3 Insulin-like peptide INSL5 Prorelaxin H2 Relaxin receptor 1 Relaxin receptor 2 Relaxin-3 receptor 1 Relaxin-3 receptor 2 Relaxin-3	P04090 P51460 Q8TDU9 Q8WXD0 Q8WXF3 Q9HBX9 Q9NSD7 Q9Y5Q6	GPCR135 GPCR142 GPR100 GPR106 GREAT INSL3 INSL5 INSL7 LGR7 LGR8 RLF RLN2 RLN3 RLN3R1 RLN3R2 RLNL RXFP1 RXFP2 RXFP3 RXFP4 RXN3 SALPR ZINS4	Homo sapiens (human)
Caspase-mediated cleavage of cytoskeletal proteins	Alpha-adducin Caspase-3 Caspase-6 Caspase-7 Caspase-8 Drebrin-like protein Gelsolin Growth arrest-specific protein 2 Microtubule-associated protein tau Plectin Spectrin alpha chain, non-erythrocytic 1 Vimentin	O43903 P06396 P08670 P10636 P35611 P42574 P55210 P55212 Q13813 Q14790 Q15149 Q9UJU6	ADD1 ADDA CASP3 CASP6 CASP7 CASP8 CMAP CPP32 DBNL GAS2 GSN MAPT MAPTL MCH2 MCH3 MCH5 MTBT1 NEAS PLEC PLEC1 SH3P7 SPTA2 SPTAN1 TAU VIM	Homo sapiens (human)
HDL assembly	Alpha-2-macroglobulin Apolipoprotein A-I Palmitoyltransferase ZDHHC8 Phospholipid-transporting ATPase ABCA1 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	O95477 P01023 P02647 P17612 P22612 P22694 Q9ULC8	A2M ABC1 ABCA1 APOA1 CERP CPAMD5 KIAA1292 PKACA PRKACA PRKACB PRKACG ZDHHC8 ZDHHCL1 ZNF378	Homo sapiens (human)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	6-pyruvoyl tetrahydrobiopterin synthase Calmodulin-1 Dihydrofolate reductase GTP cyclohydrolase 1 feedback regulatory protein GTP cyclohydrolase 1 Heat shock protein HSP 90-alpha Nitric oxide synthase 3 RAC-alpha serine/threonine-protein kinase Sepiapterin reductase cGMP-dependent protein kinase 2	P00374 P07900 P0DP23 P29474 P30047 P30793 P31749 P35270 Q03393 Q13237	AKT1 CALM CALM1 CAM CAM1 DHFR DYT5 GCH GCH1 GCHFR GFRP HSP90A HSP90AA1 HSPC1 HSPCA NOS3 PKB PRKG2 PRKGR2 PTS RAC SPR	Homo sapiens (human)
Cellular response to hypoxia	Endothelial PAS domain-containing protein 1 Hypoxia-inducible factor 1-alpha inhibitor Hypoxia-inducible factor 1-alpha	Q16665 Q99814 Q9NWT6	BHLHE73 BHLHE78 EPAS1 FIH1 HIF1A HIF1AN HIF2A MOP1 MOP2 PASD2 PASD8	Homo sapiens (human)
Transport of RCbl within the body	CD320 antigen Low density lipoprotein receptor adapter protein 1 Low-density lipoprotein receptor-related protein 2 Lysosomal cobalamin transport escort protein LMBD1 Lysosomal cobalamin transporter ABCD4 Multidrug resistance-associated protein 1 Transcobalamin-1 Transcobalamin-2	O14678 P20061 P20062 P33527 P98164 Q5SW96 Q9NPF0 Q9NUN5	8D6A ABCC1 ABCD4 ARH C6orf209 CD320 LDLRAP1 LMBRD1 LRP2 MRP MRP1 NESI PXMP1L TC1 TC2 TCN1 TCN2	Homo sapiens (human)
Sensing of DNA Double Strand Breaks	DNA repair protein RAD50 Double-strand break repair protein MRE11 Histone acetyltransferase KAT5 Importin subunit alpha-1 Nibrin Serine-protein kinase ATM	O60934 P49959 P52292 Q13315 Q92878 Q92993	ATM HNGS1 HTATIP KAT5 KPNA2 MRE11 MRE11A NBN NBS NBS1 P95 RAD50 RCH1 SRP1 TIP60	Homo sapiens (human)
Metabolism of ingested SeMet, Sec, MeSec into H2Se	Adenosylhomocysteinase Cystathionine beta-synthase Cystathionine gamma-lyase Glycine N-methyltransferase Histamine N-methyltransferase Nicotinamide N-methyltransferase S-adenosylmethionine synthase isoform type-1 Selenocysteine lyase	P23526 P32929 P35520 P40261 P50135 Q00266 Q14749 Q96I15	AHCY AMS1 CBS CTH GNMT HNMT MAT1A MATA1 NNMT SAHH SCL SCLY	Homo sapiens (human)

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