GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **926 - 950** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	Insulin-like growth factor 2 mRNA-binding protein 1 Insulin-like growth factor 2 mRNA-binding protein 2 Insulin-like growth factor 2 mRNA-binding protein 3	O00425 Q9NZI8 Q9Y6M1	CRDBP IGF2BP1 IGF2BP2 IGF2BP3 IMP2 IMP3 KOC1 VICKZ1 VICKZ2 VICKZ3 ZBP1	Homo sapiens (human)
Sensory processing of sound by outer hair cells of the cochlea	55 kDa erythrocyte membrane protein Band 4.1-like protein 1 Band 4.1-like protein 3 Cadherin-23 Calcium and integrin-binding family member 2 Chloride intracellular channel protein 5 Epidermal growth factor receptor kinase substrate 8-like protein 2 Epidermal growth factor receptor kinase substrate 8 Espin-like protein Espin Ezrin Fascin-2 Gelsolin Glutaredoxin domain-containing cysteine-rich protein 1 Glutaredoxin domain-containing cysteine-rich protein 2 Harmonin LHFPL tetraspan subfamily member 5 protein Moesin Myosin-9 Myosin-IIIa Myosin-IIIb Otogelin-like protein Otogelin Pejvakin Peripheral plasma membrane protein CASK Plastin-1 Potassium voltage-gated channel subfamily KQT member 4 Prestin Protocadherin-15 Radixin Rho family-interacting cell polarization regulator 2 Spectrin alpha chain, non-erythrocytic 1 Spectrin beta chain, non-erythrocytic 1 Stereocilin Taperin Transmembrane channel-like protein 1 Transmembrane channel-like protein 2 Transmembrane inner ear expressed protein Twinfilin-1 Twinfilin-2 Unconventional myosin-Ic Unconventional myosin-VIIa Unconventional myosin-XV Whirlin Xin actin-binding repeat-containing protein 2 pre-mRNA splicing regulator USH1G	A4UGR9 A6NFK2 A8MXD5 B1AK53 O00159 O14926 O14936 O75838 P06396 P15311 P26038 P35241 P35579 P56696 P58743 Q00013 Q01082 Q0ZLH3 Q12792 Q12929 Q13402 Q13813 Q14651 Q3ZCN5 Q495M9 Q4KMQ1 Q6IBS0 Q6ZRI0 Q6ZVH7 Q7RTU9 Q8NEV4 Q8NEW7 Q8TAF8 Q8TDI7 Q8TDI8 Q8WXR4 Q96QU1 Q9H251 Q9H4G0 Q9H6S3 Q9NZA1 Q9P202 Q9UKN7 Q9Y2J2 Q9Y4F9 Q9Y6N9	AIE75 C12orf64 C20orf145 C6orf32 C9orf75 CASK CDH23 CIB2 CLIC5 CMYA3 DAL1 DFNB25 DFNB31 DFNB36 DFNB59 DIFF48 DXS552E EMP55 EPB41L1 EPB41L3 EPS8 EPS8L2 EPS8R2 ESPN ESPNL EZR FAM65B FSCN2 GRXCR1 GRXCR2 GSN KCNQ4 KIAA0338 KIAA0386 KIAA0987 KIAA1526 KIAA1774 KIAA1812 KIP2 LHFPL5 LIN2 MPP1 MSN MYH9 MYO15 MYO15A MYO1C MYO3A MYO3B MYO7A NEAS OTGN OTOG OTOGL PCDH15 PJVK PL48 PLS1 PRES PTK9 PTK9L RDX RIPOR2 SANS SLC26A5 SPTA2 SPTAN1 SPTB2 SPTBN1 STRC TMC1 TMC2 TMHS TMIE TPRN TWF1 TWF2 USH1B USH1C USH1F USH1G VIL2 WHRN XIRP2	Homo sapiens (human)
Cyclin D associated events in G1	CDK-activating kinase assembly factor MAT1 Cullin-1 Cyclin-H Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 inhibitor B Cyclin-dependent kinase 4 inhibitor C Cyclin-dependent kinase 4 inhibitor D Cyclin-dependent kinase 4 Cyclin-dependent kinase 6 Cyclin-dependent kinase 7 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase inhibitor 1C Cyclin-dependent kinase inhibitor 2A Cyclin-dependent kinases regulatory subunit 1 G1/S-specific cyclin-D1 G1/S-specific cyclin-D2 G1/S-specific cyclin-D3 G1/S-specific cyclin-E1 G1/S-specific cyclin-E2 Polyubiquitin-B Polyubiquitin-C Protein-tyrosine kinase 6 Retinoblastoma-associated protein Retinoblastoma-like protein 1 Retinoblastoma-like protein 2 S-phase kinase-associated protein 1 S-phase kinase-associated protein 2 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F2 Transcription factor E2F3 Transcription factor E2F4 Transcription factor E2F5 Tyrosine-protein kinase ABL1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00716 O60674 O96020 P00519 P06400 P07948 P0CG47 P0CG48 P11802 P24385 P24864 P24941 P28749 P30153 P30154 P30279 P30281 P38936 P42771 P42772 P42773 P46527 P49918 P50613 P51946 P51948 P55273 P61024 P62714 P62979 P62987 P63151 P63208 P67775 Q00534 Q01094 Q08999 Q13309 Q13616 Q13882 Q14186 Q14188 Q14209 Q15329 Q16254 Q9Y5P8	ABL ABL1 BCL1 BRK CAK CAK1 CAP20 CAP35 CCND1 CCND2 CCND3 CCNE CCNE1 CCNE2 CCNH CDK2 CDK4 CDK6 CDK7 CDKN1 CDKN1A CDKN1B CDKN1C CDKN2 CDKN2A CDKN2B CDKN2C CDKN2D CDKN6 CDKN7 CIP1 CKS1 CKS1B CUL1 DP1 DP2 E2F1 E2F2 E2F3 E2F4 E2F5 EMC19 FBXL1 JAK2 JTK7 JTK8 KIAA0075 KIP1 KIP2 LYN MAT1 MDA6 MNAT1 MO15 MTS1 MTS2 OCP2 PIC1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R3B PPP2R3L PRAD1 PTK6 RB1 RB2 RBBP3 RBL1 RBL2 RNF66 RPS27A SDI1 SKP1 SKP1A SKP2 STK1 TCEB1L TFDP1 TFDP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WAF1 p27	Homo sapiens (human)
PCP/CE pathway	Disheveled-associated activator of morphogenesis 1 Frizzled-1 Frizzled-3 Frizzled-6 Frizzled-7 Profilin-1 Protein Wnt-11 Protein Wnt-4 Protein Wnt-5a Protein Wnt-5b Proto-oncogene Wnt-1 Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Ras-related C3 botulinum toxin substrate 3 Segment polarity protein dishevelled homolog DVL-1 Segment polarity protein dishevelled homolog DVL-2 Segment polarity protein dishevelled homolog DVL-3 Transforming protein RhoA Tyrosine-protein kinase RYK Tyrosine-protein kinase transmembrane receptor ROR2 Vang-like protein 2	O14640 O14641 O60353 O75084 O96014 P04628 P07737 P15153 P34925 P41221 P56705 P60763 P61586 P63000 Q01974 Q92997 Q9H1J7 Q9NPG1 Q9ULK5 Q9UP38 Q9Y4D1	ARH12 ARHA DAAM1 DVL1 DVL2 DVL3 FZD1 FZD3 FZD6 FZD7 INT1 JTK5A KIAA0208 KIAA0666 KIAA1215 NTRKR2 PFN1 RAC1 RAC2 RAC3 RHO12 RHOA ROR2 RYK STB1 TC25 VANGL2 WNT1 WNT11 WNT4 WNT5A WNT5B	Homo sapiens (human)
Presynaptic depolarization and calcium channel opening	Dihydropyridine receptor alpha 2 subunit Voltage-dependent L-type calcium channel subunit beta-1 Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent L-type calcium channel subunit beta-3 Voltage-dependent L-type calcium channel subunit beta-4 Voltage-dependent N-type calcium channel subunit alpha-1B Voltage-dependent P/Q-type calcium channel subunit alpha-1A Voltage-dependent R-type calcium channel subunit alpha-1E Voltage-dependent calcium channel gamma-2 subunit Voltage-dependent calcium channel gamma-4 subunit Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2/delta-3	O00305 O00555 P54284 Q00975 Q02641 Q08289 Q15878 Q8IZS8 Q9NY47 Q9UBN1 Q9UIU0 Q9Y698	CACH4 CACH5 CACH6 CACN3 CACNA1A CACNA1B CACNA1E CACNA2D1 CACNA2D2 CACNA2D3 CACNB1 CACNB2 CACNB3 CACNB4 CACNG2 CACNG4 CACNL1A4 CACNL1A5 CACNL1A6 CACNLB1 CACNLB2 CACNLB3 CACNLB4 KIAA0558 MYSB	Homo sapiens (human)
SARS-CoV-2 modulates autophagy	Elongation factor Tu, mitochondrial Membrane protein Microtubule-associated proteins 1A/1B light chain 3B ORF3a protein ORF7a protein UV radiation resistance-associated gene protein Vacuolar protein sorting-associated protein 11 homolog Vacuolar protein sorting-associated protein 16 homolog Vacuolar protein sorting-associated protein 18 homolog Vacuolar protein sorting-associated protein 33A Vacuolar protein sorting-associated protein 33B Vacuolar protein sorting-associated protein 41 homolog Vacuolar protein sorting-associated protein 45 Vam6/Vps39-like protein	P0DTC3 P0DTC5 P0DTC7 P49411 P49754 Q96AX1 Q96JC1 Q9GZQ8 Q9H267 Q9H269 Q9H270 Q9NRW7 Q9P253 Q9P2Y5	3a 7a KIAA0770 KIAA1475 M MAP1ALC3 MAP1LC3B RNF108 TLP TUFM UVRAG VAM6 VPS11 VPS16 VPS18 VPS33A VPS33B VPS39 VPS41 VPS45 VPS45A VPS45B	Homo sapiens (human)
Formation of the nephric duct	Bone morphogenetic protein 4 Catenin beta-1 DNA-binding protein inhibitor ID-4 Fibroblast growth factor 2 Histone-lysine N-methyltransferase MECOM Homeobox protein EMX2 Homeobox protein Hox-A6 Homeobox protein Hox-B4 LIM/homeobox protein Lhx1 Nephronectin Paired box protein Pax-2 Paired box protein Pax-8 Placenta-specific gene 8 protein Protein odd-skipped-related 1 Proto-oncogene tyrosine-protein kinase receptor Ret Protocadherin-19 Trans-acting T-cell-specific transcription factor GATA-3 WAP four-disulfide core domain protein 2	P07949 P09038 P12644 P17483 P23771 P31267 P35222 P47928 P48742 Q02962 Q03112 Q04743 Q06710 Q14508 Q6UXI9 Q8TAB3 Q8TAX0 Q9NZF1	BHLHB27 BMP2B BMP4 CDHF12 CDHR16 CTNNB CTNNB1 DVR4 EGFL6L EMX2 EVI1 FGF2 FGFB GATA3 HE4 HOX1B HOX2F HOXA6 HOXB4 ID4 KIAA1313 LHX1 LIM-1 LIM1 MDS1 MECOM NPNT ODD OSR1 PAX2 PAX8 PCDH19 PLAC8 POEM PRDM3 PTC RET WAP5 WFDC2	Homo sapiens (human)
NPAS4 regulates expression of target genes	Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Basic helix-loop-helix ARNT-like protein 1 Brain-derived neurotrophic factor CREB-binding protein Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 E3 ubiquitin-protein ligase Mdm2 Exportin-1 GTP-binding protein GEM IQ motif and SEC7 domain-containing protein 3 Insulin Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Neuronal PAS domain-containing protein 4 Nicotinamide phosphoribosyltransferase Protein c-Fos Proto-oncogene tyrosine-protein kinase receptor Ret RNA binding protein fox-1 homolog 3 Serine/threonine-protein kinase PLK2 Synaptotagmin-10	A6NFN3 O00327 O14980 P01100 P01308 P07949 P23560 P27361 P27540 P28482 P43490 P55040 Q00535 Q00987 Q15078 Q6XYQ8 Q8IUM7 Q92793 Q9HBZ2 Q9NYY3 Q9UPP2	ARNT ARNT2 ARNTL BDNF BHLHE1 BHLHE2 BHLHE5 BHLHE79 BMAL1 CBP CDHF12 CDHR16 CDK5 CDK5R CDK5R1 CDKN5 CREBBP CRM1 ERK1 ERK2 FOS G0S7 GEM INS IQSEC3 KIAA0307 KIAA1110 KIR MAPK1 MAPK3 MDM2 MOP3 NAMPT NCK5A NPAS4 NXF PASD10 PASD3 PBEF PBEF1 PLK2 PRKM1 PRKM2 PRKM3 PSSALRE PTC RBFOX3 RET SNK SYT10 XPO1	Homo sapiens (human)
Proton-coupled monocarboxylate transport	Basigin Embigin Monocarboxylate transporter 1 Monocarboxylate transporter 2 Monocarboxylate transporter 3 Monocarboxylate transporter 4	O15427 O60669 O95907 P35613 P53985 Q6PCB8	BSG EMB MCT1 MCT2 MCT3 MCT4 SLC16A1 SLC16A3 SLC16A7 SLC16A8	Homo sapiens (human)
Formation of RNA Pol II elongation complex	AF4/FMR2 family member 4 CDK-activating kinase assembly factor MAT1 Cyclin-H Cyclin-K Cyclin-T1 Cyclin-T2 Cyclin-dependent kinase 7 Cyclin-dependent kinase 9 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 ELL-associated factor 1 ELL-associated factor 2 Elongin-A2 Elongin-A Elongin-B Elongin-C FACT complex subunit SPT16 FACT complex subunit SSRP1 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Negative elongation factor A Negative elongation factor B Negative elongation factor C/D Negative elongation factor E Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Parafibromin Protein AF-9 Protein ENL Protein IWS1 homolog RNA polymerase II elongation factor ELL RNA polymerase II subunit A C-terminal domain phosphatase RNA polymerase II-associated factor 1 homolog RNA polymerase-associated protein CTR9 homolog RNA polymerase-associated protein LEO1 RNA polymerase-associated protein RTF1 homolog Superkiller complex protein 8 Transcription elongation factor A protein 1 Transcription elongation factor SPT4 Transcription elongation factor SPT5 Transcription elongation factor SPT6	O00267 O15514 O60563 O60583 O75909 P13984 P18074 P18615 P19387 P19388 P19447 P23193 P24928 P30876 P32780 P35269 P36954 P42568 P50613 P50750 P51946 P51948 P52298 P52434 P52435 P53803 P55199 P61218 P62487 P62875 P63272 Q03111 Q08945 Q09161 Q13888 Q13889 Q14241 Q15369 Q15370 Q6P1J9 Q6PD62 Q6ZYL4 Q7KZ85 Q8IXH7 Q8IYF1 Q8N7H5 Q8WVC0 Q8WX92 Q92541 Q92759 Q96CJ1 Q96JC9 Q96ST2 Q9GZS3 Q9H3P2 Q9UHB7 Q9Y5B0 Q9Y5B9	AF5Q31 AF9 AFF4 BTF2 BTF2P44 C19orf17 C1orf28 C6orf175 CAK CAK1 CAP35 CBP20 CBP80 CCNH CCNK CCNT1 CCNT2 CDC2L4 CDC73 CDK7 CDK9 CDKN7 COBRA1 CPR4 CTDP1 CTR9 EAF1 EAF2 ELL ELOA ELOA2 ELOB ELOC ENL ERCC2 ERCC3 FACT140 FACT80 FACTP140 FCP1 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2S HRPT2 IWS1 IWS1L KIAA0155 KIAA0162 KIAA0252 KIAA1182 LEO1 LTG19 MAT1 MCEF MLLT1 MLLT3 MNAT1 MO15 NCBP NCBP1 NCBP2 NELFA NELFB NELFCD NELFD NELFE PAF1 PD2 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF RAP30 RAP74 RD RDBP RDL RNF66 RPB7 RTF1 SH2BP1 SKIC8 SPT4H SPT5 SPT5H SPT6H SSRP1 STK1 SUPT16H SUPT4H SUPT4H1 SUPT5H SUPT6H TAK TCEA1 TCEB1 TCEB2 TCEB3 TCEB3B TCEB3L TFIIS TH1 TH1L TRAITS TTDA WDR61 WHSC2 XPB XPBC XPD XPDC YEATS1 YEATS3	Homo sapiens (human)
AKT phosphorylates targets in the cytosol	Bcl2-associated agonist of cell death Caspase-9 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase makorin-1 Glycogen synthase kinase-3 alpha Glycogen synthase kinase-3 beta Inhibitor of nuclear factor kappa-B kinase subunit alpha Proline-rich AKT1 substrate 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Tuberin	O15111 P31749 P31751 P38936 P46527 P49815 P49840 P49841 P55211 Q00987 Q92934 Q96B36 Q9UHC7 Q9Y243	AKT1 AKT1S1 AKT2 AKT3 BAD BBC6 BCL2L8 CAP20 CASP9 CDKN1 CDKN1A CDKN1B CHUK CIP1 GSK3A GSK3B IKKA KIP1 MCH6 MDA6 MDM2 MKRN1 PIC1 PKB PKBG PRAS40 RAC RNF61 SDI1 TCF16 TSC2 TSC4 WAF1 p27	Homo sapiens (human)
Sunitinib-resistant PDGFR mutants	Platelet-derived growth factor receptor alpha	P16234	PDGFR2 PDGFRA RHEPDGFRA	Homo sapiens (human)
MECP2 regulates neuronal receptors and channels	G protein-regulated inducer of neurite outgrowth 1 Glutamate receptor 2 Glutamate receptor ionotropic, NMDA 2A Glutamate receptor ionotropic, NMDA 2B Hepatocyte growth factor receptor Histone deacetylase 1 Histone deacetylase 2 Kappa-type opioid receptor Mu-type opioid receptor Paired amphipathic helix protein Sin3a Peptidyl-prolyl cis-trans isomerase FKBP5 Short transient receptor potential channel 3 Solute carrier family 2, facilitated glucose transporter member 3 Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 4	P08581 P11169 P18031 P29074 P35372 P41145 P42262 Q12879 Q13224 Q13451 Q13507 Q13547 Q7Z2K8 Q92769 Q96ST3	AIG6 FKBP5 FKBP51 GLUR2 GLUT3 GPRIN1 GRIA2 GRIN2A GRIN2B GluA2 HDAC1 HDAC2 KIAA1893 MET MOR1 NMDAR2A NMDAR2B OPRK OPRK1 OPRM1 PTP1B PTPN1 PTPN4 RPD3L1 SIN3A SLC2A3 TRP3 TRPC3	Homo sapiens (human)
Oxidative Stress Induced Senescence	Cellular tumor antigen p53 Chromobox protein homolog 2 Chromobox protein homolog 6 Chromobox protein homolog 8 Cyclin-dependent kinase 4 inhibitor B Cyclin-dependent kinase 4 inhibitor C Cyclin-dependent kinase 4 inhibitor D Cyclin-dependent kinase 4 Cyclin-dependent kinase 6 Cyclin-dependent kinase inhibitor 2A Dual specificity mitogen-activated protein kinase kinase 3 Dual specificity mitogen-activated protein kinase kinase 4 Dual specificity mitogen-activated protein kinase kinase 6 Dual specificity mitogen-activated protein kinase kinase 7 E3 SUMO-protein ligase CBX4 E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase RING1 E3 ubiquitin-protein ligase RING2 Helicase MOV-10 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 Interferon beta Lysine-specific demethylase 6B MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 MAP kinase-activated protein kinase 5 Misshapen-like kinase 1 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Mitogen-activated protein kinase kinase kinase 5 Mitogen-activated protein kinase kinase kinase kinase 4 Polycomb complex protein BMI-1 Polycomb protein EED Polycomb protein SUZ12 Polyhomeotic-like protein 1 Polyhomeotic-like protein 2 Polyhomeotic-like protein 3 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Protein argonaute-1 Protein argonaute-3 Protein argonaute-4 Protein c-Fos TRAF2 and NCK-interacting protein kinase Thioredoxin Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F2 Transcription factor E2F3 Transcription factor Jun Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein Tumor suppressor ARF Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00257 O00716 O14733 O15054 O15151 O60814 O75530 O95503 O95819 P01100 P01574 P04637 P04908 P05412 P06899 P0C5Y9 P0CG47 P0CG48 P10599 P11802 P16104 P20671 P23527 P27361 P28482 P33778 P35226 P42771 P42772 P42773 P45983 P45984 P45985 P46734 P49137 P52564 P53779 P55273 P57053 P58876 P62805 P62807 P62979 P62987 P68431 P78364 P84243 Q00534 Q00987 Q01094 Q06587 Q09028 Q14186 Q14188 Q14209 Q14781 Q15022 Q15759 Q15910 Q16539 Q16576 Q16644 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8IW41 Q8IXK0 Q8N257 Q8N4C8 Q8N726 Q8NDV7 Q8NDX5 Q93077 Q93079 Q96A08 Q99496 Q99683 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9H9G7 Q9HC52 Q9HCE1 Q9HCJ0 Q9HCK5 Q9UKE5 Q9UL18 Q9UPQ9	AGO1 AGO3 AGO4 ASK1 B55 BAP1 BMI1 CAGH26 CBX2 CBX4 CBX6 CBX8 CDK4 CDK6 CDKN2 CDKN2A CDKN2B CDKN2C CDKN2D CDKN6 CHET9 CSBP CSBP1 CSBP2 CSPB1 DING DP1 DP2 E2F1 E2F2 E2F3 EDR1 EDR2 EDR3 EED EIF2C1 EIF2C3 EIF2C4 ERK1 ERK2 EZH2 FOS G0S7 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HGK HIPI3 HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 IFB IFNB IFNB1 JJAZ1 JMJD3 JNK1 JNK2 JNK3 JNK3A JNKK1 JNKK2 JUN KDM6B KIAA0075 KIAA0160 KIAA0346 KIAA0551 KIAA0687 KIAA1093 KIAA1460 KIAA1567 KIAA1582 KIAA1631 KMT6 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K5 MAP4K4 MAP4K6 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAPKKK5 MDM2 MDM4 MDMX MEK3 MEK4 MEK6 MEK7 MEKK5 MINK MINK1 MKK3 MKK4 MKK6 MKK7 MLM MOV10 MTS1 MTS2 MXI2 NIK P53 PC3 PCGF4 PH1 PH2 PH3 PHC1 PHC2 PHC3 PRAK PRKM1 PRKM10 PRKM11 PRKM2 PRKM3 PRKM8 PRKM9 PRKMK3 PRKMK4 PRKMK6 PRKMK7 RBAP46 RBAP48 RBBP3 RBBP4 RBBP7 RC1 RING1 RING1A RING1B RNF1 RNF2 RNF51 RPS27A SAPK1 SAPK1A SAPK1B SAPK1C SAPK2 SAPK2A SAPK2B SEK1 SERK1 SKK1 SKK2 SKK3 SKK4 SUZ12 TFDP1 TFDP2 TNIK TNRC6 TNRC6A TNRC6B TNRC6C TP53 TRDX TRX TRX1 TSH2B TXN UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 YSK2 ZC3	Homo sapiens (human)
Transferrin endocytosis and recycling	Hereditary hemochromatosis protein Metalloreductase STEAP3 Metalloreductase STEAP4 Mucolipin-1 Serotransferrin Transferrin receptor protein 1 Transferrin receptor protein 2 V-type proton ATPase 116 kDa subunit a 1 V-type proton ATPase 116 kDa subunit a 2 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 116 kDa subunit a 4 V-type proton ATPase 16 kDa proteolipid subunit c V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B, brain isoform V-type proton ATPase subunit B, kidney isoform V-type proton ATPase subunit C 1 V-type proton ATPase subunit C 2 V-type proton ATPase subunit D V-type proton ATPase subunit E 1 V-type proton ATPase subunit E 2 V-type proton ATPase subunit F V-type proton ATPase subunit G 1 V-type proton ATPase subunit G 2 V-type proton ATPase subunit G 3 V-type proton ATPase subunit H V-type proton ATPase subunit S1 V-type proton ATPase subunit d 1 V-type proton ATPase subunit d 2 V-type proton ATPase subunit e 1 V-type proton ATPase subunit e 2	O15342 O75348 O95670 P02786 P02787 P15313 P21281 P21283 P27449 P36543 P38606 P61421 Q13488 Q15904 Q16864 Q30201 Q658P3 Q687X5 Q8N8Y2 Q8NEY4 Q8NHE4 Q93050 Q96A05 Q96LB4 Q99437 Q9GZU1 Q9HBG4 Q9UI12 Q9UP52 Q9Y487 Q9Y5K8	ATP6A1 ATP6AP1 ATP6B1 ATP6B2 ATP6C ATP6D ATP6E ATP6E1 ATP6E2 ATP6EL2 ATP6F ATP6G ATP6G1 ATP6G2 ATP6G3 ATP6H ATP6IP1 ATP6J ATP6L ATP6M ATP6N1 ATP6N1A ATP6N1B ATP6N1C ATP6N2 ATP6S1 ATP6S14 ATP6V0A1 ATP6V0A2 ATP6V0A3 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E ATP6V0E1 ATP6V0E2 ATP6V0E2L ATP6V1A ATP6V1A1 ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1EL2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATPL C7orf32 HFE HLAH MCOLN1 ML4 NG38 STAMP2 STEAP3 STEAP4 TCIRG1 TF TFR2 TFRC TNFAIP9 TRPML1 TSAP6 VATB VATC VATD VATF VATPS1 VPATPD VPP1 VPP2 VPP3 XAP3	Homo sapiens (human)
Generation of second messenger molecules	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Actin nucleation-promoting factor WAS Ena/VASP-like protein FYN-binding protein 1 GRB2-related adapter protein 2 HLA class II histocompatibility antigen, DP alpha 1 chain HLA class II histocompatibility antigen, DP beta 1 chain HLA class II histocompatibility antigen, DQ alpha 1 chain HLA class II histocompatibility antigen, DQ alpha 2 chain HLA class II histocompatibility antigen, DQ beta 1 chain HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DR alpha chain HLA class II histocompatibility antigen, DR beta 3 chain HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DRB1 beta chain Immunoglobulin superfamily member 2 Linker for activation of T-cells family member 1 Lymphocyte cytosolic protein 2 Protein enabled homolog SH2/SH3 adapter protein NCK1 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 T cell receptor alpha chain constant T cell receptor alpha variable 19 T cell receptor alpha variable 29/delta variable 5 T cell receptor alpha variable 8-4 T cell receptor beta constant 1 T cell receptor beta variable 12-3 T cell receptor beta variable 7-9 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase ITK/TSK Tyrosine-protein kinase Lck Tyrosine-protein kinase ZAP-70 Vasodilator-stimulated phosphoprotein	A0A0A6YYK7 O15117 O43561 O75791 O75914 P01730 P01733 P01737 P01848 P01850 P01903 P01906 P01909 P01911 P01920 P04234 P04435 P04437 P04440 P05538 P06239 P07766 P09693 P13762 P16333 P16885 P19174 P20036 P42768 P43403 P50552 P79483 Q08881 Q13094 Q13153 Q13177 Q30154 Q8N8S7 Q93033 Q9UI08	CD101 CD3D CD3E CD3G CD4 EMT ENAH EVL EWI101 FYB FYB1 GADS GRAP2 GRB2L GRID HLA-DP1A HLA-DP1B HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRA1 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-DXA HLA-DXB HLASB IGSF2 IMD2 ITK LAT LCK LCP2 LYK MENA NCK NCK1 OPHN3 PAK1 PAK2 PAK3 PLC1 PLCG1 PLCG2 RNB6 SLAP130 SRK T3D T3E T3G TCRA TCRBV12S3 TCRBV8S1 TRAC TRAV19 TRAV29DV5 TRAV8-4 TRBC1 TRBV12-3 TRBV7-9 V7 VASP WAS ZAP70	Homo sapiens (human)
Dual Incision in GG-NER	Chromodomain-helicase-DNA-binding protein 1-like Cullin-4A Cullin-4B DNA damage-binding protein 1 DNA damage-binding protein 2 DNA excision repair protein ERCC-1 DNA excision repair protein ERCC-5 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA polymerase kappa DNA repair endonuclease XPF DNA repair protein complementing XP-A cells E3 ubiquitin-protein ligase RBX1 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Poly [ADP-ribose] polymerase 1 Poly [ADP-ribose] polymerase 2 Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P07992 P09874 P0CG47 P0CG48 P12004 P15927 P18074 P19447 P23025 P27694 P28340 P28715 P32780 P35244 P35249 P35250 P35251 P40937 P40938 P49005 P56282 P62877 P62979 P62987 Q07864 Q13619 Q13620 Q13888 Q13889 Q15054 Q16531 Q6ZYL4 Q86WJ1 Q92466 Q92759 Q92889 Q9HCU8 Q9NR33 Q9NRF9 Q9UBT6 Q9UGN5	ADPRT ADPRT2 ADPRTL2 ALC1 BTF2 BTF2P44 C6orf175 CHD1L CHRAC17 CUL4A CUL4B DDB1 DDB2 DINB1 DPE2 ERCC1 ERCC11 ERCC2 ERCC3 ERCC4 ERCC5 ERCM2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 KIAA0039 KIAA0695 PARP1 PARP2 PCNA POLD POLD1 POLD2 POLD3 POLD4 POLDS POLE POLE1 POLE2 POLE3 POLE4 POLK PPOL RBX1 REPA1 REPA2 REPA3 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RNF75 ROC1 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A TTDA UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 XAP1 XPA XPAC XPB XPBC XPD XPDC XPF XPG XPGC	Homo sapiens (human)
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	Cyclin-dependent kinase 2 G1/S-specific cyclin-E1 G1/S-specific cyclin-E2 Retinoblastoma-associated protein	O96020 P06400 P24864 P24941	CCNE CCNE1 CCNE2 CDK2 CDKN2 RB1	Homo sapiens (human)
Formation of annular gap junctions	AP-2 complex subunit mu Clathrin heavy chain 1 Clathrin heavy chain 2 Clathrin light chain A Clathrin light chain B Disabled homolog 2 Dynamin-1 Dynamin-2 Gap junction alpha-1 protein	P09496 P09497 P17302 P50570 P53675 P98082 Q00610 Q05193 Q96CW1	AP2M1 CLAPM1 CLH17 CLH22 CLTA CLTB CLTC CLTCL CLTCL1 CLTCL2 CLTD DAB2 DNM DNM1 DNM2 DOC2 DYN2 GJA1 GJAL KIAA0034 KIAA0109	Homo sapiens (human)
Eukaryotic Translation Elongation	Elongation factor 1-alpha 1 Elongation factor 1-alpha 2 Elongation factor 1-beta Elongation factor 1-delta Elongation factor 1-gamma Putative elongation factor 1-alpha-like 3	P24534 P26641 P29692 P68104 Q05639 Q5VTE0	EEF1A EEF1A1 EEF1A1P5 EEF1A2 EEF1AL EEF1AL3 EEF1B EEF1B2 EEF1D EEF1G EF1A EF1B EF1D EF1G LENG7 STN	Homo sapiens (human)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	15-hydroxyprostaglandin dehydrogenase [NAD(+)] 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase Aldo-keto reductase family 1 member C3 Carbonyl reductase [NADPH] 1 Hematopoietic prostaglandin D synthase Prostacyclin synthase Prostaglandin E synthase 2 Prostaglandin E synthase 3 Prostaglandin E synthase Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Prostaglandin reductase 2 Prostaglandin-H2 D-isomerase Prostamide/prostaglandin F synthase Thromboxane-A synthase	O14684 O60760 P15428 P16152 P23219 P24557 P35354 P41222 P42330 Q15185 Q16647 Q8N8N7 Q8TBF2 Q9H7Z7 Q9UNU6	AKR1C3 C1orf93 C9orf15 CBR CBR1 COX1 COX2 CRN CYP12 CYP5 CYP5A1 CYP8 CYP8A1 CYP8B1 DDH1 FAM213B GSTS HPGD HPGDS HSD17B5 KIAA0119 MGST1L1 MPGES1 P23 PDS PGDH1 PGDS PGES PGES2 PGFS PIG12 PRXL2B PTGDS PTGDS2 PTGES PTGES2 PTGES3 PTGIS PTGR2 PTGS1 PTGS2 SDR21C1 SDR36C1 TBXAS1 TEBP TXAS ZADH1	Homo sapiens (human)
RHO GTPases Activate WASPs and WAVEs	Abl interactor 1 Abl interactor 2 Actin nucleation-promoting factor WAS Actin nucleation-promoting factor WASL Actin, cytoplasmic 1 Actin, cytoplasmic 2 Actin-binding protein WASF1 Actin-binding protein WASF2 Actin-binding protein WASF3 Actin-related protein 2/3 complex subunit 1A Actin-related protein 2/3 complex subunit 1B Actin-related protein 2/3 complex subunit 2 Actin-related protein 2/3 complex subunit 3 Actin-related protein 2/3 complex subunit 4 Actin-related protein 2/3 complex subunit 5 Actin-related protein 2 Actin-related protein 3 BAR/IMD domain-containing adapter protein 2 Cell division control protein 42 homolog Cytoplasmic FMR1-interacting protein 1 Cytoplasmic FMR1-interacting protein 2 Focal adhesion kinase 1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 NCK-interacting protein with SH3 domain Nck-associated protein 1-like Nck-associated protein 1 Protein BRICK1 Ras-related C3 botulinum toxin substrate 1 SH2/SH3 adapter protein NCK1 Tyrosine-protein kinase ABL1 Tyrosine-protein kinase BTK WAS/WASL-interacting protein family member 1 WAS/WASL-interacting protein family member 2 WAS/WASL-interacting protein family member 3	A6NGB9 O00401 O15143 O15144 O15145 O15511 O43516 P00519 P16333 P27361 P28482 P42768 P55160 P59998 P60709 P60953 P61158 P61160 P63000 P63261 Q05397 Q06187 Q7L576 Q8IZP0 Q8TF74 Q8WUW1 Q92558 Q92747 Q96F07 Q9NYB9 Q9NZQ3 Q9UPY6 Q9UQB8 Q9Y2A7 Q9Y6W5	ABI1 ABI2 ABL ABL1 ACTB ACTG ACTG1 ACTR2 ACTR3 AF3P21 AGMX1 ARC16 ARC20 ARC21 ARC34 ARC41 ARGBPIA ARP2 ARP3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ATK BAIAP2 BPK BRK1 BTK C3orf10 CDC42 CR16 CYFIP1 CYFIP2 ERK1 ERK2 FAK FAK1 HEM1 HEM2 IMD2 JTK7 KIAA0068 KIAA0269 KIAA0587 KIAA0900 KIAA1168 MAPK1 MAPK3 NAP1 NCK NCK1 NCKAP1 NCKAP1L NCKIPSD PIR121 PRKM1 PRKM2 PRKM3 PTK2 RAC1 SCAR1 SCAR3 SOP2L SPIN90 SSH3BP1 TC25 WAS WASF1 WASF2 WASF3 WASL WASPIP WAVE1 WAVE2 WAVE3 WICH WIP WIPF1 WIPF2 WIPF3 WIRE	Homo sapiens (human)
RHO GTPases activate IQGAPs	CAP-Gly domain-containing linker protein 1 Cadherin-1 Calmodulin-1 Catenin alpha-1 Catenin beta-1 Cell division control protein 42 homolog Menin Ras GTPase-activating-like protein IQGAP1 Ras GTPase-activating-like protein IQGAP2 Ras GTPase-activating-like protein IQGAP3 Ras-related C3 botulinum toxin substrate 1	O00255 P0DP23 P12830 P30622 P35221 P35222 P46940 P60953 P63000 Q13576 Q86VI3	CALM CALM1 CAM CAM1 CDC42 CDH1 CDHE CLIP1 CTNNA1 CTNNB CTNNB1 CYLN1 IQGAP1 IQGAP2 IQGAP3 KIAA0051 MEN1 RAC1 RSN SCG2 TC25 UVO	Homo sapiens (human)
Activation, translocation and oligomerization of BAX	Apoptosis regulator BAX BH3-interacting domain death agonist	P55957 Q07812	BAX BCL2L4 BID	Homo sapiens (human)
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	Isocitrate dehydrogenase [NADP] cytoplasmic	O75874	IDH1 PICD	Homo sapiens (human)

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