GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **1226 - 1250** of **2090** in total

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Pathway Name ▲	Protein Name	UniProt ID	Gene Symbol
PDH complex synthesizes acetyl-CoA from PYR	Dihydrolipoyl dehydrogenase, mitochondrial Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pyruvate dehydrogenase protein X component, mitochondrial	O00330 P08559 P09622 P10515 P11177 P29803	DLAT DLD DLTA GCSL LAD PDHA1 PDHA2 PDHAL PDHB PDHX PDX1 PHE1A PHE1B PHE3
PECAM1 interactions	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Integrin alpha-V Integrin beta-3 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Platelet endothelial cell adhesion molecule Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6	P05106 P06239 P06241 P06756 P07947 P07948 P16284 P19174 P29350 Q06124 Q92835	FYN GP3A HCP INPP5D ITGAV ITGB3 JTK8 LCK LYN MSK8 PECAM1 PLC1 PLCG1 PTP1C PTP2C PTPN11 PTPN6 SHIP SHIP1 SHPTP2 VNRA VTNR YES YES1
PERK regulates gene expression	Cyclic AMP-dependent transcription factor ATF-4 Endoplasmic reticulum chaperone BiP Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit 3 Eukaryotic translation initiation factor 2-alpha kinase 3	P05198 P11021 P18848 P20042 P41091 Q9NZJ5	ATF4 CREB2 EIF2A EIF2AK3 EIF2B EIF2G EIF2S1 EIF2S2 EIF2S3 GRP78 HSPA5 PEK PERK TXREB
PI Metabolism	Tumor necrosis factor alpha-induced protein 8-like protein 1 Tumor necrosis factor alpha-induced protein 8-like protein 2 Tumor necrosis factor alpha-induced protein 8-like protein 3 Tumor necrosis factor alpha-induced protein 8	O95379 Q5GJ75 Q6P589 Q8WVP5	TIPE3 TNFAIP8 TNFAIP8L1 TNFAIP8L2 TNFAIP8L3
PI and PC transport between ER and Golgi membranes	Phosphatidylinositol transfer protein beta isoform	P48739	PITPNB
PI-3K cascade:FGFR1	Fibroblast growth factor 10 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 GRB2-associated-binding protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	O15520 P05230 P08620 P09038 P10767 P11487 P27986 P31371 P42336 Q06124 Q13480 Q8WU20 Q9GZV9 Q9HCT0 Q9NP95	FGF1 FGF10 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF9 FGFA FGFB FRS2 GAB1 GRB1 HST HST2 HSTF1 HSTF2 HYPF INT2 KS3 PIK3CA PIK3R1 PTP2C PTPN11 SHPTP2
PI-3K cascade:FGFR2	Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 GRB2-associated-binding protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	O15520 O43320 O76093 P05230 P08620 P09038 P10767 P11487 P21781 P27986 P31371 P42336 Q06124 Q13480 Q8WU20 Q9GZV9 Q9HCT0 Q9NP95	FGF1 FGF10 FGF16 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FRS2 GAB1 GRB1 HST HST2 HSTF1 HSTF2 HYPF INT2 KGF KS3 PIK3CA PIK3R1 PTP2C PTPN11 SHPTP2
PI-3K cascade:FGFR3	Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 GRB2-associated-binding protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	O43320 O76093 P05230 P08620 P09038 P27986 P31371 P42336 Q06124 Q13480 Q8WU20 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF2 FGF20 FGF23 FGF4 FGF9 FGFA FGFB FRS2 GAB1 GRB1 HST HSTF1 HYPF KS3 PIK3CA PIK3R1 PTP2C PTPN11 SHPTP2
PI-3K cascade:FGFR4	Beta-klotho Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 GRB2-associated-binding protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	O43320 O76093 O95750 P05230 P08620 P09038 P10767 P22455 P27986 P31371 P42336 Q06124 Q13480 Q86Z14 Q8WU20 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF9 FGFA FGFB FGFR4 FRS2 GAB1 GRB1 HST HST2 HSTF1 HSTF2 HYPF JTK2 KLB KS3 PIK3CA PIK3R1 PTP2C PTPN11 SHPTP2 TKF
PI3K Cascade	Beta-klotho Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Insulin receptor substrate 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphoinositide 3-kinase regulatory subunit 4 Receptor-type tyrosine-protein kinase FLT3 Toll-like receptor 9 Tyrosine-protein phosphatase non-receptor type 11	O00459 O15520 O43320 O76093 O95750 P05230 P08620 P09038 P10767 P11487 P21781 P22455 P27986 P31371 P35568 P36888 P42336 P42338 P49771 Q06124 Q13480 Q86Z14 Q8NEB9 Q8WU20 Q99570 Q9GZV9 Q9HCT0 Q9NP95 Q9NR96 Q9UQC2 Q9Y4H2	CD135 FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 GAB1 GAB2 GRB1 HST HST2 HSTF1 HSTF2 HYPF INT2 IRS1 IRS2 JTK2 KGF KIAA0571 KLB KS3 PIK3C1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTP2C PTPN11 SHPTP2 STK1 TKF TLR9 VPS15 VPS34
PI3K events in ERBB2 signaling	Epidermal growth factor receptor GRB2-associated-binding protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Receptor tyrosine-protein kinase erbB-2	O14511 O14944 P00533 P01133 P04626 P27986 P35070 P42336 P56975 Q02297 Q13480 Q8WWG1 Q99075	BTC DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GAB1 GGF GRB1 HBEGF HEGFL HER1 HER2 HGL HRGA MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NTAK PIK3CA PIK3R1 SMDF
PI3K events in ERBB4 signaling	Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor	O14511 O14944 P27986 P35070 P42336 P56975 Q02297 Q8WWG1 Q99075	BTC DTR DTS EREG GGF GRB1 HBEGF HEGFL HGL HRGA NDF NRG1 NRG2 NRG3 NRG4 NTAK PIK3CA PIK3R1 SMDF
PI3K/AKT Signaling	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Amphiregulin B-lymphocyte antigen CD19 Beta-klotho Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-like 1 Interleukin-33 Mast/stem cell growth factor receptor Kit Membrane protein Myeloid differentiation primary response protein MyD88 Nucleoprotein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphoinositide 3-kinase adapter protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proline-rich protein 5 Proto-oncogene tyrosine-protein kinase Src Proto-oncogene vav Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Rho-related GTP-binding protein RhoG Serine/threonine-protein kinase Sgk1 Serine/threonine-protein kinase mTOR Striatin T-cell receptor-associated transmembrane adapter 1 T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 TNF receptor-associated factor 6 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein phosphatase non-receptor type 11	O00141 O00329 O00459 O14511 O14944 O15520 O15530 O43320 O43815 O76093 O95750 O95760 P00533 P01127 P01133 P01135 P03372 P04626 P05230 P06239 P06241 P08581 P08620 P09038 P09619 P0DTC5 P0DTC9 P10721 P10747 P10767 P11487 P12931 P14210 P15153 P15391 P15498 P15514 P16234 P21781 P22455 P27986 P31371 P31749 P31751 P33681 P35070 P35568 P36888 P42081 P42336 P42338 P42345 P49771 P51617 P56975 P63000 P84095 P85299 Q01638 Q02297 Q06124 Q13480 Q5T1C6 Q6PIZ9 Q6R327 Q6UW88 Q6ZUJ8 Q86Z14 Q8WU20 Q8WWG1 Q92569 Q92731 Q96RU7 Q99075 Q99836 Q9BPZ7 Q9BVC4 Q9GZV9 Q9HCT0 Q9NP95 Q9NWZ3 Q9UQC2 Q9Y243 Q9Y4H2 Q9Y4K3	AKT1 AKT2 AKT3 AREG AREGB ARHG BCAP BTC C20orf97 C9orf26 CD135 CD19 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 CTMP DER4 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ESR ESR1 ESR2 ESTRB FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRAP FRAP1 FRAP2 FRS2 FYN GAB1 GAB2 GBL GGF GRB1 HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRGA HST HST2 HSTF1 HSTF2 HYPF IL1F11 IL1RL1 IL33 INT2 IRAK IRAK1 IRAK4 IRS1 IRS2 JTK2 KGF KIAA0571 KIAA1999 KIT KLB KS3 LAB7 LCK LST8 M MAPKAP1 MET MIP1 MLN19 MLST8 MTOR MYD88 N NDF NEU NFHEV NGL NIPK NR3A1 NR3A2 NRG1 NRG2 NRG3 NRG4 NTAK PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PDK1 PDPK1 PIK3AP1 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PKB PKBG PROTOR1 PRR5 PTP2C PTPN11 RAC RAC1 RAC2 RAFT1 RAPT1 RHEPDGFRA RHOG RICTOR RNF85 SCFR SDGF SGK SGK1 SHPTP2 SIN1 SIS SKIP3 SMDF SRC SRC1 ST2 STK1 STRN T1 TC25 TCRIM TGFA THEM4 TKF TRAF6 TRAT1 TRB3 TRIB3 VAV VAV1
PI3K/AKT activation	Beta-nerve growth factor High affinity nerve growth factor receptor Insulin receptor substrate 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Transforming protein RhoA	O00459 P01138 P04629 P27986 P35568 P42336 P42338 P61586 Q9Y4H2	ARH12 ARHA GRB1 IRS1 IRS2 MTC NGF NGFB NTRK1 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 RHO12 RHOA TRK TRKA
PI5P Regulates TP53 Acetylation	Cellular tumor antigen p53 Dual specificity mitogen-activated protein kinase kinase 6 Histone acetyltransferase p300 Inhibitor of growth protein 2 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase	P04637 P48426 P52564 P78356 Q09472 Q13526 Q86T03 Q8TBX8 Q9H160	C14orf9 EP300 ING1L ING2 MAP2K6 MEK6 MKK6 P300 P53 PI5P4KA PIN1 PIP4K2A PIP4K2B PIP4K2C PIP4P1 PIP5K2 PIP5K2A PIP5K2B PIP5K2C PRKMK6 SKK3 TMEM55B TP53
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Amphiregulin B-lymphocyte antigen CD19 Beta-klotho Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin receptor Insulin Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-like 1 Interleukin-33 Mast/stem cell growth factor receptor Kit Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Myeloid differentiation primary response protein MyD88 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Phosphatidylinositol 4-phosphate 5-kinase type-1 beta Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Phosphoinositide 3-kinase adapter protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Proto-oncogene vav Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase Radiation-inducible immediate-early gene IEX-1 Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Rho-related GTP-binding protein RhoG Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Striatin T-cell receptor-associated transmembrane adapter 1 T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 TNF receptor-associated factor 6 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein phosphatase non-receptor type 11	O00329 O00459 O14511 O14944 O14986 O15520 O43320 O43815 O60331 O76093 O95750 O95760 P00533 P01127 P01133 P01135 P01308 P03372 P04626 P05230 P06213 P06239 P06241 P08581 P08620 P09038 P09619 P10721 P10747 P10767 P11487 P12931 P14210 P15153 P15391 P15498 P15514 P16234 P21781 P22455 P27361 P27986 P28482 P30153 P30154 P31371 P31749 P33681 P35070 P35568 P36888 P42081 P42336 P42338 P46695 P48426 P49771 P51617 P56975 P62714 P63000 P67775 P78356 P84095 Q01638 Q02297 Q06124 Q13362 Q13480 Q14738 Q15172 Q15173 Q16537 Q6PIZ9 Q6UW88 Q6ZUJ8 Q86Z14 Q8TBX8 Q8WU20 Q8WWG1 Q92569 Q92731 Q99075 Q99755 Q99836 Q9GZV9 Q9HCT0 Q9NP95 Q9NWZ3 Q9UQC2 Q9Y4H2 Q9Y4K3	AKT1 AREG AREGB ARHG BCAP BTC C9orf26 CD135 CD19 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 DER4 DIF2 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ERK1 ERK2 ESR ESR1 ESR2 ESTRB FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 FYN GAB1 GAB2 GGF GRB1 HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRGA HST HST2 HSTF1 HSTF2 HYPF IER3 IEX1 IL1F11 IL1RL1 IL33 INS INSR INT2 IRAK IRAK1 IRAK4 IRS1 IRS2 JTK2 KGF KIAA0044 KIAA0571 KIAA0589 KIT KLB KS3 LAB7 LCK MAPK1 MAPK3 MET MLN19 MYD88 NDF NEU NFHEV NGL NR3A1 NR3A2 NRG1 NRG2 NRG3 NRG4 NTAK PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PI5P4KA PIK3AP1 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PIP5K2 PIP5K2A PIP5K2B PIP5K2C PKB PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRG1 PRKM1 PRKM2 PRKM3 PTP2C PTPN11 RAC RAC1 RAC2 RHEPDGFRA RHOG RNF85 SCFR SDGF SHPTP2 SIS SMDF SRC SRC1 ST2 STK1 STM7 STRN T1 TC25 TCRIM TGFA TKF TRAF6 TRAT1 VAV VAV1
PINK1-PRKN Mediated Mitophagy	Autophagy protein 5 E3 ubiquitin-protein ligase parkin Microtubule-associated proteins 1A/1B light chain 3A Microtubule-associated proteins 1A/1B light chain 3B Mitochondrial import receptor subunit TOM20 homolog Mitochondrial import receptor subunit TOM22 homolog Mitochondrial import receptor subunit TOM40 homolog Mitochondrial import receptor subunit TOM5 homolog Mitochondrial import receptor subunit TOM6 homolog Mitochondrial import receptor subunit TOM7 homolog Mitochondrial import receptor subunit TOM70 Mitofusin-1 Mitofusin-2 Polyubiquitin-B Polyubiquitin-C Sequestosome-1 Serine/threonine-protein kinase PINK1, mitochondrial Transcription termination factor 3, mitochondrial Ubiquitin-like protein ATG12 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Voltage-dependent anion-selective channel protein 1	O60260 O94817 O94826 O95140 O96008 P0CG47 P0CG48 P21796 P62979 P62987 Q13501 Q15388 Q8IWA4 Q8N4H5 Q96B49 Q96E29 Q9BXM7 Q9GZQ8 Q9H1Y0 Q9H492 Q9NS69 Q9P0U1	APG12 APG12L APG5L ASP ATG12 ATG5 C19orf1 C9orf105 CPRP1 KIAA0016 KIAA0214 KIAA0719 MAP1ALC3 MAP1LC3A MAP1LC3B MFN1 MFN2 MTERF3 MTERFD1 OBTP ORCA OSIL PARK2 PEREC1 PINK1 PRKN RPS27A SQSTM1 TOM22 TOM40 TOM5 TOM6 TOM7 TOM70 TOMM07 TOMM20 TOMM22 TOMM40 TOMM5 TOMM6 TOMM7 TOMM70 TOMM70A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VDAC VDAC1
PIWI-interacting RNA (piRNA) biogenesis	ATP-dependent RNA helicase TDRD9 Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Heat shock protein HSP 90-alpha Inactive peptidyl-prolyl cis-trans isomerase FKBP6 Mitochondrial cardiolipin hydrolase Myb-related protein A Piwi-like protein 1 Piwi-like protein 2 Piwi-like protein 4 Probable ATP-dependent RNA helicase DDX4 Protein maelstrom homolog Putative ATP-dependent RNA helicase TDRD12 RNA helicase Mov10l1 Small RNA 2'-O-methyltransferase Tudor and KH domain-containing protein Tudor domain-containing protein 1 Tudor domain-containing protein 6	O15514 O60522 O75344 P07900 P10243 P19387 P19388 P24928 P30876 P36954 P52434 P52435 P53803 P61218 P62487 P62875 Q587J7 Q5T8I9 Q7Z3Z4 Q8N2A8 Q8NDG6 Q8TC59 Q8WWH4 Q96J94 Q96JY0 Q9BXT4 Q9BXT6 Q9NQI0 Q9Y2W6	ALP1 AMYB ANKL1 ASZ1 C14orf75 C1orf59 C7orf7 DDX4 ECAT8 FKBP36 FKBP6 GASZ HENMT1 HILI HIWI HIWI2 HSP90A HSP90AA1 HSPC1 HSPCA MAEL MOV10L1 MYBL1 PIWI PIWIL1 PIWIL2 PIWIL4 PLD6 POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF RPB7 TDRD1 TDRD12 TDRD2 TDRD6 TDRD9 TDRKH VASA
PKA activation	Adenylate cyclase type 1 Adenylate cyclase type 2 Adenylate cyclase type 3 Adenylate cyclase type 4 Adenylate cyclase type 5 Adenylate cyclase type 6 Adenylate cyclase type 7 Adenylate cyclase type 8 Adenylate cyclase type 9 Calmodulin-1 Neurobeachin cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit	O43306 O60266 O60503 O95622 P0DP23 P10644 P13861 P17612 P22612 P22694 P31321 P31323 P40145 P51828 Q08462 Q08828 Q8NFM4 Q8NFP9	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 BCL8B CALM CALM1 CAM CAM1 KIAA0037 KIAA0422 KIAA0511 KIAA0520 KIAA1060 KIAA1544 LYST2 NBEA PKACA PKR1 PKR2 PRKACA PRKACB PRKACG PRKAR1 PRKAR1A PRKAR1B PRKAR2 PRKAR2A PRKAR2B TSE1
PKA activation in glucagon signalling	Adenylate cyclase type 1 Adenylate cyclase type 2 Adenylate cyclase type 3 Adenylate cyclase type 4 Adenylate cyclase type 5 Adenylate cyclase type 6 Adenylate cyclase type 7 Adenylate cyclase type 8 Adenylate cyclase type 9 Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Guanine nucleotide-binding protein G(s) subunit alpha isoforms short cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit	O43306 O60266 O60503 O95622 P10644 P13861 P17612 P22612 P22694 P31321 P31323 P40145 P51828 P63092 Q08462 Q08828 Q5JWF2 Q8NFM4	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GNAS GNAS1 GSP KIAA0037 KIAA0422 KIAA0511 KIAA0520 KIAA1060 PKACA PKR1 PKR2 PRKACA PRKACB PRKACG PRKAR1 PRKAR1A PRKAR1B PRKAR2 PRKAR2A PRKAR2B TSE1
PKA-mediated phosphorylation of CREB	cAMP-dependent protein kinase catalytic subunit PRKX cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	P17612 P22612 P22694 P51817	PKACA PKX1 PRKACA PRKACB PRKACG PRKX
PKA-mediated phosphorylation of key metabolic factors	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Carbohydrate-responsive element-binding protein cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	P16118 P17612 P22612 P22694 Q9NP71	BHLHD14 F6PK MIO MLXIPL PFKFB1 PFRX PKACA PRKACA PRKACB PRKACG WBSCR14
PKMTs methylate histone lysines	Actin-histidine N-methyltransferase Activating transcription factor 7-interacting protein 1 Histone H3.1 Histone H3.2 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase 2A Histone-lysine N-methyltransferase 2B Histone-lysine N-methyltransferase 2C Histone-lysine N-methyltransferase 2D Histone-lysine N-methyltransferase ASH1L Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Histone-lysine N-methyltransferase EZH2 Histone-lysine N-methyltransferase KMT5B Histone-lysine N-methyltransferase KMT5C Histone-lysine N-methyltransferase MECOM Histone-lysine N-methyltransferase NSD2 Histone-lysine N-methyltransferase NSD3 Histone-lysine N-methyltransferase PRDM16 Histone-lysine N-methyltransferase PRDM9 Histone-lysine N-methyltransferase SETD1A Histone-lysine N-methyltransferase SETD1B Histone-lysine N-methyltransferase SETD2 Histone-lysine N-methyltransferase SETD7 Histone-lysine N-methyltransferase SETDB1 Histone-lysine N-methyltransferase SETDB2 Histone-lysine N-methyltransferase SMYD3 Histone-lysine N-methyltransferase SUV39H1 Histone-lysine N-methyltransferase SUV39H2 Histone-lysine N-methyltransferase, H3 lysine-36 specific Histone-lysine N-methyltransferase, H3 lysine-79 specific N-lysine methyltransferase KMT5A N-lysine methyltransferase SETD6 N-lysine methyltransferase SMYD2 Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p105 subunit Polycomb protein EED Polycomb protein SUZ12 Protein dpy-30 homolog Retinoblastoma-binding protein 5 Set1/Ash2 histone methyltransferase complex subunit ASH2 Transcription factor p65 WD repeat-containing protein 5 Zinc finger protein AEBP2	O14686 O15047 O43463 O75530 O96028 P19838 P61964 P62805 P68431 Q00653 Q03112 Q03164 Q04206 Q09028 Q15022 Q15047 Q15291 Q15910 Q16576 Q4FZB7 Q6VMQ6 Q6ZN18 Q71DI3 Q86TU7 Q86Y97 Q8NEZ4 Q8TBK2 Q8TEK3 Q8WTS6 Q96KQ7 Q96L73 Q96T68 Q9BYW2 Q9BZ95 Q9C005 Q9H5I1 Q9H7B4 Q9H9B1 Q9HAZ2 Q9NQR1 Q9NQV7 Q9NR48 Q9NRG4 Q9UBL3 Q9UMN6 Q9UPS6	AEBP2 ALL1 ALR ARA267 ASH1L ASH2L ASH2L1 ATF7IP BAT8 BIG3 C13orf4 C14orf154 C6orf30 CHET9 CLLD8 CXXC7 DOT1L DPY30 EED EHMT1 EHMT2 ESET EUHMTASE1 EVI1 EZH2 G9A GLP H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HALR HIF1 HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST4H4 HRX HRX2 HTRX HYPB JJAZ1 KIAA0067 KIAA0160 KIAA0304 KIAA0339 KIAA1076 KIAA1090 KIAA1420 KIAA1506 KIAA1675 KIAA1717 KIAA1732 KIAA1814 KIAA1876 KMT1A KMT1B KMT1C KMT1D KMT1E KMT1F KMT2A KMT2B KMT2C KMT2D KMT2F KMT2G KMT2H KMT3A KMT3B KMT3C KMT4 KMT5A KMT5B KMT5C KMT6 KMT7 LYT10 MCAF MCAF1 MDS1 MECOM MEL1 MLL MLL1 MLL2 MLL3 MLL4 MMSET NFKB1 NFKB2 NFKB3 NG36 NSD1 NSD2 NSD3 PFM13 PFM6 PRDM16 PRDM3 PRDM9 PRSET7 RBAP46 RBAP48 RBBP4 RBBP5 RBBP7 RBQ3 RELA SET07 SET1 SET1A SET1B SET2 SET7 SET8 SET9 SETD1A SETD1B SETD2 SETD3 SETD6 SETD7 SETD8 SETDB1 SETDB2 SMYD2 SMYD3 SUV39H SUV39H1 SUV39H2 SUV420H1 SUV420H2 SUZ12 TRX1 TRX2 TRX5 WBP7 WDR5 WHSC1 WHSC1L1 ZMYND1 ZNFN3A1
PKR-mediated signaling	ATP-dependent RNA helicase A Alpha-synuclein Cellular tumor antigen p53 Centromere protein S Centromere protein X Cyclin-dependent kinase 1 DnaJ homolog subfamily C member 3 Double-stranded RNA-specific adenosine deaminase Dual specificity mitogen-activated protein kinase kinase 6 E3 ISG15--protein ligase HERC5 E3 ubiquitin-protein ligase ARIH1 E3 ubiquitin-protein ligase FANCL E3 ubiquitin/ISG15 ligase TRIM25 Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit 3 Fanconi anemia core complex-associated protein 100 Fanconi anemia core complex-associated protein 20 Fanconi anemia core complex-associated protein 24 Fanconi anemia group A protein Fanconi anemia group B protein Fanconi anemia group C protein Fanconi anemia group E protein Fanconi anemia group F protein Fanconi anemia group G protein Fanconi anemia group M protein Heat shock 70 kDa protein 1-like Heat shock 70 kDa protein 1A Heat shock 70 kDa protein 1B Heat shock cognate 71 kDa protein Heat shock-related 70 kDa protein 2 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Interferon-induced, double-stranded RNA-activated protein kinase Interferon-inducible double-stranded RNA-dependent protein kinase activator A Interleukin enhancer-binding factor 2 Interleukin enhancer-binding factor 3 Mitochondrial antiviral-signaling protein NF-kappa-B essential modulator Non-structural protein 1 Nucleophosmin Nucleoprotein Protein TRS1 Protein Tat RISC-loading complex subunit TARBP2 SH2/SH3 adapter protein NCK1 SUMO-conjugating enzyme UBC9 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Small ubiquitin-related modifier 1 Sphingosine kinase 1 Tyrosine-protein phosphatase non-receptor type 2 Ubiquitin-like protein ISG15 Ubiquitin/ISG15-conjugating enzyme E2 L6 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like	A8MT69 O14920 O14933 O15111 O15287 O15360 O75569 P03418 P03496 P04609 P04637 P05161 P05198 P06493 P06748 P0DMV8 P0DMV9 P11142 P16333 P17706 P19525 P20042 P30153 P30154 P34931 P37840 P40763 P41091 P42224 P52564 P54652 P55265 P62714 P63165 P63279 P67775 Q00597 Q08211 Q0VG06 Q12905 Q12906 Q13217 Q14258 Q15172 Q15633 Q6NZ36 Q6SVX2 Q7Z434 Q8IYD8 Q8N2Z9 Q8NB91 Q9BTP7 Q9HB96 Q9NPI8 Q9NW38 Q9NX74 Q9NYA1 Q9UII4 Q9Y4X5 Q9Y6K9	ADAR ADAR1 APITD1 APRF ARI ARIH1 C17orf70 C19orf40 C1orf86 CDC2 CDC28A CDK1 CDKN1 CEB1 CEBP1 CENPS CENPX CHUK DDX9 DHX9 DNAJC3 DRBF DSRAD DUS2 DUS2L EFP EIF2A EIF2AK2 EIF2B EIF2G EIF2S1 EIF2S2 EIF2S3 FAA FAAP10 FAAP100 FAAP16 FAAP20 FAAP24 FAC FACA FACC FACE FANCA FANCB FANCC FANCE FANCF FANCG FANCH FANCL FANCM FIP3 G1P1 G1P2 HERC5 HSC70 HSP72 HSP73 HSPA1 HSPA10 HSPA1A HSPA1B HSPA1L HSPA2 HSPA8 HSX70 IFI4 IKBKB IKBKG IKKA IKKB ILF2 ILF3 IPS1 ISG15 KIAA1271 KIAA1596 LKP MAP2K6 MAVS MEK6 MHF1 MHF2 MKK6 MOP6 MPHOSPH4 N NACP NCK NCK1 NDH2 NEMO NF45 NF90 NPM NPM1 NS P34CDC2 P53 P58IPK PACT PARK1 PHF9 PKR PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PRKMK6 PRKR PRKRA PRKRI PTPN2 PTPT RAX RNF147 SK1 SKK3 SMT3C SMT3H3 SNCA SPHK SPHK1 SPK STAT1 STAT3 STRA13 SUMO1 TARBP2 TCF16 TP53 TRBP TRIM25 TRS1 UBC9 UBCE9 UBCH7BP UBCH8 UBE2I UBE2L6 UBL1 UCRP VISA XRCC9 ZNF147 tat
PLC beta mediated events	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 Guanine nucleotide-binding protein G(q) subunit alpha Guanine nucleotide-binding protein subunit alpha-11 Guanine nucleotide-binding protein subunit alpha-14 Guanine nucleotide-binding protein subunit alpha-15 Inositol 1,4,5-trisphosphate receptor type 2 Inositol 1,4,5-trisphosphate receptor type 3 Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 S-adenosylhomocysteine hydrolase-like protein 1	O43865 O95837 P29992 P30679 P50148 Q00722 Q01970 Q14571 Q14573 Q14643 Q15147 Q9NQ66	AHCYL1 DCAL GA11 GAQ GNA11 GNA14 GNA15 GNA16 GNAQ INSP3R1 IRBIT ITPR1 ITPR2 ITPR3 KIAA0581 PLCB1 PLCB2 PLCB3 PLCB4 XPVKONA

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