GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **476 - 500** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Synthesis of PIPs at the late endosome membrane	1-phosphatidylinositol 3-phosphate 5-kinase Myotubularin-related protein 9 Myotubularin Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 Phosphatidylinositol-3-phosphate phosphatase MTMR7 Phosphoinositide 3-kinase regulatory subunit 4 Polyphosphoinositide phosphatase Protein VAC14 homolog	O00443 Q08AM6 Q13496 Q13614 Q8NEB9 Q92562 Q96QG7 Q99570 Q9NYA4 Q9Y216 Q9Y2I7	C8orf9 CG2 FIG4 KIAA0274 KIAA0647 KIAA0981 KIAA1073 MTM1 MTMR2 MTMR4 MTMR7 MTMR8 MTMR9 PIK3C2A PIK3C3 PIK3R4 PIKFYVE PIP5K3 SAC3 TAX1BP2 TRX VAC14 VPS15 VPS34 ZFYVE11	Homo sapiens (human)
Aspirin ADME	ATP-binding cassette sub-family C member 2 ATP-binding cassette sub-family C member 3 Acyl-coenzyme A synthetase ACSM2A, mitochondrial Acyl-coenzyme A synthetase ACSM2B, mitochondrial Acyl-coenzyme A synthetase ACSM4, mitochondrial Acyl-coenzyme A synthetase ACSM5, mitochondrial Albumin Basigin Cholinesterase Cocaine esterase Cytochrome P450 2C19 Cytochrome P450 2C8 Cytochrome P450 2C9 Cytochrome P450 2D6 Cytochrome P450 2E1 Cytochrome P450 3A4 Glycine N-acyltransferase-like protein 1 Glycine N-acyltransferase-like protein 2 Glycine N-acyltransferase-like protein 3 Glycine N-acyltransferase Liver carboxylesterase 1 Monocarboxylate transporter 1 Solute carrier family 22 member 7 UDP-glucuronosyltransferase 1-6 UDP-glucuronosyltransferase 1A1 UDP-glucuronosyltransferase 1A3 UDP-glucuronosyltransferase 1A4 UDP-glucuronosyltransferase 1A5 UDP-glucuronosyltransferase 1A7 UDP-glucuronosyltransferase 1A8 UDP-glucuronosyltransferase 1A9 UDP-glucuronosyltransferase 2A1 UDP-glucuronosyltransferase 2A2 UDP-glucuronosyltransferase 2A3 UDP-glucuronosyltransferase 2B10 UDP-glucuronosyltransferase 2B11 UDP-glucuronosyltransferase 2B15 UDP-glucuronosyltransferase 2B17 UDP-glucuronosyltransferase 2B28 UDP-glucuronosyltransferase 2B4 UDP-glucuronosyltransferase 2B7 UDP-glucuronosyltransferase 3A1 UDP-glucuronosyltransferase 3A2	O00748 O15438 O60656 O75310 O75795 P02768 P05181 P06133 P06276 P08684 P0C7M7 P0DTE4 P0DTE5 P10632 P10635 P11712 P16662 P19224 P22309 P22310 P23141 P33261 P35503 P35504 P35613 P36537 P53985 P54855 Q08AH3 Q3SY77 Q5SZD4 Q68CK6 Q6IB77 Q6NUN0 Q6NUS8 Q6UWM9 Q8WU03 Q92887 Q969I3 Q9BY64 Q9HAW7 Q9HAW9 Q9Y694	ABCC2 ABCC3 ACGNAT ACSM2 ACSM2A ACSM2B ACSM4 ACSM5 ALB BCHE BSG C6orf140 CAT CES1 CES2 CHE1 CMOAT CMOAT1 CMOAT2 CMRP CYP2C10 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2DL1 CYP2E CYP2E1 CYP3A3 CYP3A4 GAT GLYAT GLYATL1 GLYATL2 GLYATL3 GNAT GNT1 ICE MACS2 MACS3 MCT1 MLP2 MRP2 MRP3 NLT OAT2 SES1 SLC16A1 SLC22A7 UGT1 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A2 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UGT2B8 UGT3A1 UGT3A2 UGTB2B9	Homo sapiens (human)
G alpha (q) signalling events	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 5-hydroxytryptamine receptor 2A 5-hydroxytryptamine receptor 2B 5-hydroxytryptamine receptor 2C Alpha-1A adrenergic receptor Alpha-1B adrenergic receptor Alpha-1D adrenergic receptor Amyloid-beta precursor protein Angiotensinogen Annexin A1 B1 bradykinin receptor B2 bradykinin receptor Beta-adrenergic receptor kinase 1 Bombesin receptor subtype-3 Chemokine XC receptor 1 Cholecystokinin receptor type A Cholecystokinin Cysteinyl leukotriene receptor 1 Cysteinyl leukotriene receptor 2 Cytokine SCM-1 beta Endothelin receptor type B Endothelin-1 receptor Endothelin-1 Endothelin-2 Endothelin-3 Extracellular calcium-sensing receptor Free fatty acid receptor 1 Free fatty acid receptor 2 Free fatty acid receptor 3 Free fatty acid receptor 4 G protein-coupled receptor kinase 5 G-protein coupled receptor 143 G-protein coupled receptor 39 G-protein coupled receptor 4 G-protein coupled receptor family C group 6 member A Gastrin-releasing peptide receptor Gastrin-releasing peptide Gastrin/cholecystokinin type B receptor Gastrin Glucagon receptor Gonadotropin-releasing hormone receptor Growth hormone secretagogue receptor type 1 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(q) subunit alpha Guanine nucleotide-binding protein subunit alpha-11 Guanine nucleotide-binding protein subunit alpha-14 Guanine nucleotide-binding protein subunit alpha-15 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Histamine H1 receptor Humanin Hypocretin neuropeptide precursor Kalirin KiSS-1 receptor Kininogen-1 Leukotriene B4 receptor 1 Leukotriene B4 receptor 2 Lymphotactin Lysophosphatidic acid receptor 1 Lysophosphatidic acid receptor 2 Lysophosphatidic acid receptor 3 Lysophosphatidic acid receptor 4 Lysophosphatidic acid receptor 5 Lysophosphatidic acid receptor 6 Melanin-concentrating hormone receptor 1 Melanin-concentrating hormone receptor 2 Melanopsin Metabotropic glutamate receptor 1 Metabotropic glutamate receptor 5 Metastasis-suppressor KiSS-1 Motilin receptor Muscarinic acetylcholine receptor M1 Muscarinic acetylcholine receptor M3 Muscarinic acetylcholine receptor M5 N-formyl peptide receptor 2 Neuromedin-B receptor Neuromedin-B Neuromedin-K receptor Neuromedin-S Neuromedin-U receptor 1 Neuromedin-U receptor 2 Neuromedin-U Neuropeptide FF receptor 1 Neuropeptide FF receptor 2 Neuropeptide S receptor Neuropeptide S Neurotensin receptor type 1 Neurotensin receptor type 2 Neurotensin/neuromedin N Orexigenic neuropeptide QRFP Orexin receptor type 2 Orexin/Hypocretin receptor type 1 Ovarian cancer G-protein coupled receptor 1 Oxytocin receptor Oxytocin-neurophysin 1 P2Y purinoceptor 11 P2Y purinoceptor 1 P2Y purinoceptor 2 P2Y purinoceptor 6 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Platelet-activating factor receptor Pro-FMRFamide-related neuropeptide FF Pro-MCH Pro-glucagon Pro-thyrotropin-releasing hormone Probable G-protein coupled receptor 132 Progonadoliberin-1 Progonadoliberin-2 Prokineticin receptor 1 Prokineticin receptor 2 Prokineticin-1 Prokineticin-2 Promotilin Prostaglandin E2 receptor EP1 subtype Prostaglandin F2-alpha receptor Protachykinin-1 Proteinase-activated receptor 1 Proteinase-activated receptor 2 Proteinase-activated receptor 3 Proteinase-activated receptor 4 Prothrombin Psychosine receptor Putative P2Y purinoceptor 10 Putative gonadotropin-releasing hormone II receptor Pyroglutamylated RF-amide peptide receptor Regulator of G-protein signaling 13 Regulator of G-protein signaling 16 Regulator of G-protein signaling 17 Regulator of G-protein signaling 18 Regulator of G-protein signaling 19 Regulator of G-protein signaling 1 Regulator of G-protein signaling 21 Regulator of G-protein signaling 2 Regulator of G-protein signaling 3 Regulator of G-protein signaling 4 Regulator of G-protein signaling 5 Regulator of G-protein signaling protein-like Rho guanine nucleotide exchange factor 25 Serum amyloid A-1 protein Substance-K receptor Substance-P receptor Tachykinin-3 Thromboxane A2 receptor Thyrotropin-releasing hormone receptor Triple functional domain protein Type-1 angiotensin II receptor Tyrosine-protein kinase BTK Uracil nucleotide/cysteinyl leukotriene receptor Urotensin-2 receptor Urotensin-2 Urotensin-2B Vasopressin V1a receptor Vasopressin V1b receptor Vasopressin-neurophysin 2-copeptin	A5PLK6 O00254 O00398 O00459 O14610 O14775 O14842 O14843 O14921 O15130 O15492 O15539 O15552 O43193 O43194 O43555 O43612 O43613 O43614 O60229 O60262 O75962 O95399 O95665 O95837 P00734 P01019 P01042 P01148 P01178 P01185 P01275 P01350 P04083 P05067 P05305 P06307 P07492 P08912 P08949 P0C0P6 P0DJI8 P11229 P12872 P14138 P16520 P20309 P20366 P20382 P20396 P20800 P21452 P21731 P24530 P25090 P25098 P25100 P25101 P25103 P25105 P25116 P27986 P28223 P28335 P28336 P29371 P29992 P30411 P30550 P30556 P30559 P30679 P30968 P30989 P30990 P32238 P32239 P32247 P34947 P34981 P34995 P35348 P35367 P35368 P37288 P41180 P41220 P41231 P41594 P41595 P42336 P43088 P43657 P46093 P46094 P46663 P47871 P47900 P47901 P47992 P48645 P49795 P49796 P49798 P50148 P50150 P50151 P51810 P55085 P58294 P59768 P61952 P62873 P62879 P63211 P63215 P63218 P83859 Q00722 Q01970 Q06187 Q08116 Q13255 Q13304 Q15077 Q15147 Q15722 Q15726 Q15743 Q2M5E4 Q5H8A3 Q5NUL3 Q5T6X5 Q6W5P4 Q765I0 Q86VW2 Q8IVG9 Q8IYL9 Q8NFJ6 Q8TCW9 Q92569 Q92633 Q92847 Q969F8 Q969V1 Q96G91 Q96P65 Q96P88 Q96RI0 Q99677 Q99705 Q9GZQ4 Q9GZQ6 Q9H1C0 Q9HAV0 Q9HB89 Q9HBW0 Q9HC23 Q9NPC1 Q9NQ66 Q9NS28 Q9NS75 Q9P2W3 Q9UBD3 Q9UBI6 Q9UBY5 Q9UGC6 Q9UHF0 Q9UHM6 Q9UK08 Q9UKP6 Q9UNW8 Q9Y271 Q9Y5X5	1R20 A4 AD1 ADRA1A ADRA1B ADRA1C ADRA1D ADRBK1 AGMX1 AGT AGTR1 AGTR1A AGTR1B ANX1 ANXA1 APP ARHGEF25 ARVP AT2R1 AT2R1B ATK AVP AVPR1 AVPR1A AVPR1B AVPR3 AXOR12 BARK BARK1 BDK BDKRB1 BDKRB2 BKR2 BL34 BLT BLT1 BLT2R BLTR BLTR2 BPK BRADYB1 BRS3 BTK BV8 CASR CCK CCKAR CCKBR CCKRA CCKRB CCXCR1 CF2R CHRM1 CHRM3 CHRM5 CMKRL1 CYSLT1 CYSLT2 CYSLT2R CYSLTR1 CYSLTR2 DUET DUO EDG2 EDG4 EDG7 EDN1 EDN2 EDN3 EDNRA EDNRB ETA ETRA ETRB F2 F2R F2RL1 F2RL2 F2RL3 FFA2 FFAR1 FFAR2 FFAR3 FFAR4 FPR2 FPRH1 FPRL1 G0S8 G2A GA11 GAIP GAQ GAS GAST GCG GCGR GEFT GHSR GNA11 GNA14 GNA15 GNA16 GNAI3IP GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 GNRH GNRH1 GNRH2 GNRHR GNRHR2 GPCR43 GPR103 GPR11 GPR120 GPR129 GPR132 GPR14 GPR143 GPR145 GPR147 GPR154 GPR16 GPR17 GPR23 GPR24 GPR38 GPR39 GPR4 GPR40 GPR41 GPR43 GPR5 GPR54 GPR65 GPR66 GPR68 GPR73 GPR73L1 GPR74 GPR92 GPR93 GPRA GPRC1A GPRC1E GPRC2A GPRC6A GPRK5 GRB1 GRH GRHR GRK2 GRK5 GRM1 GRM5 GRP GRPR HAPIP HCRT HCRTR1 HCRTR2 HN HRH1 HTR1C HTR2 HTR2A HTR2B HTR2C IER1 KALRN KIAA0581 KISS1 KISS1R KNG KNG1 LHRH LPA1 LPA2 LPA3 LPA4 LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LPC1 LTB4R LTB4R2 LTN LXA4R MCH MCHR1 MCHR2 MGLUR1 MGLUR5 MLN MLNR MOP MT-RNR2 MTLR MTLR1 NK1R NK2R NK3R NKA NKNA NKNAR NKNB NMB NMBR NMS NMU NMU2R NMUR1 NMUR2 NPFF NPFF1 NPFF2 NPFFR1 NPFFR2 NPGPR NPS NPSR1 NTRR NTS NTSR1 NTSR2 O3FAR1 OA1 OGR1 OPN4 OT OX OXT OXTR P2RU1 P2RY1 P2RY10 P2RY11 P2RY2 P2RY5 P2RY6 P2RY7 P2RY9 PAFR PAR1 PAR2 PAR3 PAR4 PCAR1 PGR14 PGR4 PIK3CA PIK3R1 PIK3R2 PIK3R3 PKR1 PKR2 PLCB1 PLCB2 PLCB3 PLCB4 PMCH PPORX PPOX PROK1 PROK2 PROKR1 PROKR2 PTAFR PTGER1 PTGFR QRFP QRFPR RGS1 RGS13 RGS16 RGS17 RGS18 RGS19 RGS2 RGS21 RGS3 RGS4 RGS5 RGSL RGSL1 RGSL2 RGSR RGSZ2 SAA1 SCYC1 SCYC2 SERPINA8 SLC1 SLT TAC1 TAC1R TAC2 TAC2R TAC3 TAC3R TACR1 TACR2 TACR3 TBXA2R TDAG8 TGR1 TR TRAD TRH TRHR TRIO URP UTS2 UTS2B UTS2D UTS2R VP VPR3 XCL1 XCL2 XCR1	Homo sapiens (human)
Translation of respiratory syncytial virus mRNAs	Fusion glycoprotein F0 Matrix protein Non-structural protein 1 Non-structural protein 2 Nucleoprotein Phosphoprotein Protein M2-1 Protein M2-2 RNA-directed RNA polymerase L	P03418 P03420 P03421 P04543 P04545 P0DOE7 P0DOE9 P28887 P88812	1B 1C F L M M2-1 M2-2 N NS1 NS2 P	Homo sapiens (human)
Defective VWF cleavage by ADAMTS13 variant	A disintegrin and metalloproteinase with thrombospondin motifs 13 von Willebrand factor	P04275 Q76LX8	ADAMTS13 C9orf8 F8VWF VWF	Homo sapiens (human)
RNA Polymerase III Chain Elongation	DNA-directed RNA polymerase III subunit RPC10 DNA-directed RNA polymerase III subunit RPC1 DNA-directed RNA polymerase III subunit RPC2 DNA-directed RNA polymerase III subunit RPC3 DNA-directed RNA polymerase III subunit RPC4 DNA-directed RNA polymerase III subunit RPC5 DNA-directed RNA polymerase III subunit RPC6 DNA-directed RNA polymerase III subunit RPC7-like DNA-directed RNA polymerase III subunit RPC7 DNA-directed RNA polymerase III subunit RPC8 DNA-directed RNA polymerase III subunit RPC9 DNA-directed RNA polymerases I and III subunit RPAC1 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Protein POLR1D, isoform 2	O14802 O15160 O15318 O75575 P05423 P0DPB5 P19388 P52434 P53803 P61218 P62875 Q9BT43 Q9BUI4 Q9H1D9 Q9NVU0 Q9NW08 Q9Y2Y1 Q9Y535	BN51 BN51T CRCP KIAA1452 KIAA1665 POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POLRF RPC11 RPC8	Homo sapiens (human)
Autointegration results in viral DNA circles	Barrier-to-autointegration factor Gag polyprotein Gag-Pol polyprotein High mobility group protein HMG-I/HMG-Y PC4 and SFRS1-interacting protein Protein Rev Protein Vpr Protein Vpu Virion infectivity factor	O75475 O75531 P04585 P04591 P04618 P05919 P17096 P69723 P69726	BAF BANF1 BCRG1 DFS70 HMGA1 HMGIY LEDGF PSIP1 PSIP2 gag gag-pol rev vif vpr vpu	Homo sapiens (human)
Manipulation of host energy metabolism	6 kDa early secretory antigenic target Alpha-enolase Phosphoglycerate kinase 1	P00558 P06733 P9WNK7	ENO1 ENO1L1 MBPB1 MPB1 PGK1 PGKA esaT6 esxA	Homo sapiens (human)
PP2A-mediated dephosphorylation of key metabolic factors	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Carbohydrate-responsive element-binding protein Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	P16118 P30153 P30154 P62714 P67775 Q14738 Q9NP71	BHLHD14 F6PK MIO MLXIPL PFKFB1 PFRX PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D WBSCR14	Homo sapiens (human)
Mitochondrial protein import	4-hydroxybenzoate polyprenyltransferase, mitochondrial 60 kDa heat shock protein, mitochondrial ADP/ATP translocase 1 ADP/ATP translocase 3 ATP synthase F(0) complex subunit C1, mitochondrial ATP synthase subunit alpha, mitochondrial ATP synthase subunit beta, mitochondrial Aconitate hydratase, mitochondrial COX assembly mitochondrial protein 2 homolog Citrate synthase, mitochondrial Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 Cx9C motif-containing protein 4 Cytochrome c oxidase assembly factor 4 homolog, mitochondrial Cytochrome c oxidase assembly factor 6 homolog Cytochrome c oxidase assembly protein COX19 Cytochrome c oxidase copper chaperone Cytochrome c1, heme protein, mitochondrial Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial FAD-linked sulfhydryl oxidase ALR Frataxin, mitochondrial GrpE protein homolog 1, mitochondrial GrpE protein homolog 2, mitochondrial Iron-sulfur cluster co-chaperone protein HscB Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial MICOS complex subunit MIC19 Metaxin-1 Metaxin-2 Mitochondrial chaperone BCS1 Mitochondrial import inner membrane translocase subunit TIM14 Mitochondrial import inner membrane translocase subunit TIM16 Mitochondrial import inner membrane translocase subunit TIM44 Mitochondrial import inner membrane translocase subunit TIM50 Mitochondrial import inner membrane translocase subunit Tim10 B Mitochondrial import inner membrane translocase subunit Tim10 Mitochondrial import inner membrane translocase subunit Tim13 Mitochondrial import inner membrane translocase subunit Tim17-A Mitochondrial import inner membrane translocase subunit Tim17-B Mitochondrial import inner membrane translocase subunit Tim21 Mitochondrial import inner membrane translocase subunit Tim22 Mitochondrial import inner membrane translocase subunit Tim23 Mitochondrial import inner membrane translocase subunit Tim8 A Mitochondrial import inner membrane translocase subunit Tim8 B Mitochondrial import inner membrane translocase subunit Tim9 Mitochondrial import receptor subunit TOM20 homolog Mitochondrial import receptor subunit TOM22 homolog Mitochondrial import receptor subunit TOM40 homolog Mitochondrial import receptor subunit TOM5 homolog Mitochondrial import receptor subunit TOM6 homolog Mitochondrial import receptor subunit TOM7 homolog Mitochondrial import receptor subunit TOM70 Mitochondrial intermembrane space import and assembly protein 40 Mitochondrial-processing peptidase subunit alpha Mitochondrial-processing peptidase subunit beta NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Non-selective voltage-gated ion channel VDAC1 Ornithine transcarbamylase, mitochondrial Presequence protease, mitochondrial Probable D-lactate dehydrogenase, mitochondrial Sorting and assembly machinery component 50 homolog Stress-70 protein, mitochondrial Tafazzin	O14925 O43615 O60220 O60830 O75390 O75431 O75439 O75746 O94826 O95169 O96008 P00480 P05496 P06576 P08574 P10809 P12235 P12236 P21796 P25705 P38646 P51553 P55789 P56277 P62072 Q10713 Q13505 Q14061 Q15388 Q16595 Q16635 Q3ZCQ8 Q49B96 Q5JRX3 Q5JTJ3 Q86WU2 Q8IWL3 Q8N4H5 Q8N4Q1 Q8TAA5 Q8WYQ3 Q96B49 Q96DA6 Q96H96 Q99595 Q99798 Q9BSY4 Q9BUK0 Q9BVV7 Q9HAV7 Q9NRP2 Q9NS69 Q9NX63 Q9NYJ1 Q9P0U1 Q9UJS0 Q9Y276 Q9Y3D7 Q9Y512 Q9Y584 Q9Y5J6 Q9Y5J7 Q9Y5J9 Q9Y5L4 Q9Y6H1	AAC1 AAC3 ACO2 AGC1 ALR ANT1 ANT3 ARALAR1 ATP5A ATP5A1 ATP5AL2 ATP5B ATP5F1A ATP5F1B ATP5G1 ATP5MC1 ATPM ATPMB ATPSB BCS1 BCS1L C16orf61 C18orf55 C19orf1 C1orf31 C22orf16 C2orf9 C6.1B C7orf17 C9orf105 CHCHD10 CHCHD2 CHCHD3 CHCHD4 CHCHD5 CHCHD7 CHCHD8 CL640 CMC2 CMC4 COA4 COA6 COQ2 COX17 COX19 CS CYC1 DDP DDP1 DDP2 DDPL DNAJC19 DNAJC20 E2IG2 EFE2 FRDA FXC1 FXN G4.5 GFER GREPEL1 GRP75 GRPEL1 GRPEL2 HERV1 HPO HSC20 HSCB HSP60 HSPA9 HSPA9B HSPD1 IDH3G INPP5E KIAA0016 KIAA0123 KIAA0719 KIAA1104 LDHD MAGMAS MIA40 MIC19 MIMT17 MIMT44 MINOS3 MP1 MPPA MPPB MTCP1 MTCP1NB MTX MTX1 MTX2 MTXN NDUFB8 OBTP OTC PAM16 PEREC1 PITRM1 PMPCA PMPCB PREP SAM50 SAMM50 SLC25A12 SLC25A13 SLC25A4 SLC25A6 TAFAZZIN TAZ TEX4 TIM10 TIM13B TIM14 TIM16 TIM17 TIM17A TIM17B TIM21 TIM22 TIM23 TIM44 TIM50 TIM8A TIM8B TIM9 TIM9A TIM9B TIMM10 TIMM10B TIMM13 TIMM13A TIMM13B TIMM14 TIMM16 TIMM17 TIMM17A TIMM17B TIMM21 TIMM22 TIMM23 TIMM44 TIMM50 TIMM8A TIMM8B TIMM9 TIMM9A TIMM9B TOM22 TOM40 TOM5 TOM6 TOM7 TOM70 TOMM07 TOMM20 TOMM22 TOMM40 TOMM5 TOMM6 TOMM7 TOMM70 TOMM70A VDAC VDAC1 X25 mt-HSP70	Homo sapiens (human)
Activation of C3 and C5	Complement C2 Complement C3 Complement C4-A Complement C4-B Complement C5 Complement factor B	P00751 P01024 P01031 P06681 P0C0L4 P0C0L5	BF BFD C2 C3 C4A C4B C4B_2 C5 CFB CO4 CPAMD1 CPAMD2 CPAMD3 CPAMD4	Homo sapiens (human)
Suppression of autophagy	Dual specificity protein phosphatase 16 N-acetyltransferase Eis Phosphatidylinositol-3-phosphatase Ras-related protein Rab-7a	O53361 P51149 P9WFK7 Q9BY84	DUSP16 KIAA1700 MKP7 RAB7 RAB7A eis sapM	Homo sapiens (human)
LXRs regulate gene expression linked to triglyceride lipolysis in adipose	Oxysterols receptor LXR-alpha Oxysterols receptor LXR-beta Perilipin-1 Retinoic acid receptor RXR-alpha Retinoic acid receptor RXR-beta	O60240 P19793 P28702 P55055 Q13133	LXRA LXRB NER NR1H2 NR1H3 NR2B1 NR2B2 PERI PLIN PLIN1 RXRA RXRB UNR	Homo sapiens (human)
Regulation of NFE2L2 gene expression	CREB-binding protein Histone acetyltransferase p300 Myc proto-oncogene protein Neurogenic locus notch homolog protein 1 Nuclear factor NF-kappa-B p105 subunit Nuclear factor erythroid 2-related factor 2 Transcription factor MafK Transcription factor p65	O60675 P01106 P19838 P46531 Q04206 Q09472 Q16236 Q92793	BHLHE39 CBP CREBBP EP300 MAFK MYC NFE2L2 NFKB1 NFKB3 NOTCH1 NRF2 P300 RELA TAN1	Homo sapiens (human)
Removal of aminoterminal propeptides from gamma-carboxylated proteins	Coagulation factor IX Coagulation factor VII Coagulation factor X Furin Growth arrest-specific protein 6 Osteocalcin Prothrombin Vitamin K-dependent protein C Vitamin K-dependent protein S Vitamin K-dependent protein Z	P00734 P00740 P00742 P02818 P04070 P07225 P08709 P09958 P22891 Q14393	AXLLG BGLAP F10 F2 F7 F9 FUR FURIN GAS6 PACE PCSK3 PROC PROS PROS1 PROZ	Homo sapiens (human)
PKA activation	Adenylate cyclase type 1 Adenylate cyclase type 2 Adenylate cyclase type 3 Adenylate cyclase type 4 Adenylate cyclase type 5 Adenylate cyclase type 6 Adenylate cyclase type 7 Adenylate cyclase type 8 Adenylate cyclase type 9 Calmodulin-1 Neurobeachin cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit	O43306 O60266 O60503 O95622 P0DP23 P10644 P13861 P17612 P22612 P22694 P31321 P31323 P40145 P51828 Q08462 Q08828 Q8NFM4 Q8NFP9	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 BCL8B CALM CALM1 CAM CAM1 KIAA0037 KIAA0422 KIAA0511 KIAA0520 KIAA1060 KIAA1544 LYST2 NBEA PKACA PKR1 PKR2 PRKACA PRKACB PRKACG PRKAR1 PRKAR1A PRKAR1B PRKAR2 PRKAR2A PRKAR2B TSE1	Homo sapiens (human)
Nephrin family interactions	Actin nucleation-promoting factor WASL Alpha-actinin-1 Alpha-actinin-2 Alpha-actinin-3 Alpha-actinin-4 CD2-associated protein Cytoplasmic protein NCK2 Kin of IRRE-like protein 1 Kin of IRRE-like protein 2 Kin of IRRE-like protein 3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 Nephrin Peripheral plasma membrane protein CASK Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Ras GTPase-activating-like protein IQGAP1 SH2/SH3 adapter protein NCK1 Spectrin alpha chain, non-erythrocytic 1 Spectrin beta chain, non-erythrocytic 1 Tyrosine-protein kinase Fyn	O00401 O00459 O14936 O43639 O43707 O60500 P06241 P12814 P16333 P27986 P35609 P42336 P42338 P46940 Q01082 Q08043 Q13813 Q6UWL6 Q86UL8 Q8IZU9 Q96J84 Q9Y5K6	ACTN1 ACTN2 ACTN3 ACTN4 ACVRINP1 AIP1 CASK CD2AP FYN GRB1 GRB4 IQGAP1 KIAA0051 KIAA0705 KIAA1867 KIRREL KIRREL1 KIRREL2 KIRREL3 LIN2 MAGI2 NCK NCK1 NCK2 NEAS NEPH1 NEPH2 NEPH3 NPHN NPHS1 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 SPTA2 SPTAN1 SPTB2 SPTBN1 WASL	Homo sapiens (human)
Impaired BRCA2 binding to RAD51	26S proteasome complex subunit SEM1 ATR-interacting protein BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein Cell cycle checkpoint control protein RAD9A Cell cycle checkpoint control protein RAD9B Cell cycle checkpoint protein RAD17 Cell cycle checkpoint protein RAD1 Checkpoint protein HUS1 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 2-binding protein 1 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Serine/threonine-protein kinase ATR	O60671 O60921 O60934 O75943 P15927 P27694 P35244 P35249 P35250 P38398 P40937 P40938 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q13535 Q14191 Q6WBX8 Q8WXE1 Q92547 Q92878 Q92993 Q96E14 Q99638 Q99708 Q99728 Q9BSD3 Q9BX63 Q9H9A7 Q9UQ84	AGS1 ATM ATR ATRIP BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C12orf32 C16orf75 C7orf76 C9orf76 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FRP1 HEX1 HNGS1 HTATIP HUS1 KAT5 KIAA0083 KIAA0259 MRE11 MRE11A NBN NBS NBS1 P95 R24L RAD1 RAD17 RAD50 RAD51 RAD51A RAD9A RAD9B RBBP8 REC1 RECA RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC2 RFC3 RFC4 RFC5 RHINO RHNO1 RMI1 RMI2 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A TOPBP1 WRN	Homo sapiens (human)
Constitutive Signaling by Aberrant PI3K in Cancer	Amphiregulin B-lymphocyte antigen CD19 BDNF/NT-3 growth factors receptor Beta-klotho Brain-derived neurotrophic factor Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Mast/stem cell growth factor receptor Kit NT-3 growth factor receptor Neurotrophin-3 Neurotrophin-4 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphoinositide 3-kinase adapter protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Proto-oncogene vav Protransforming growth factor alpha Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Rho-related GTP-binding protein RhoG Striatin T-cell receptor-associated transmembrane adapter 1 T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein phosphatase non-receptor type 11	O00329 O00459 O14511 O14944 O15520 O43320 O43815 O76093 O95750 P00533 P01127 P01133 P01135 P03372 P04626 P05230 P06239 P06241 P08581 P08620 P09038 P09619 P10721 P10747 P10767 P11487 P12931 P14210 P15153 P15391 P15498 P15514 P16234 P20783 P21781 P22455 P23560 P27986 P31371 P33681 P34130 P35070 P35568 P36888 P42081 P42336 P42338 P49771 P56975 P63000 P84095 Q02297 Q06124 Q13480 Q16288 Q16620 Q6PIZ9 Q6UW88 Q6ZUJ8 Q86Z14 Q8WU20 Q8WWG1 Q92569 Q92731 Q99075 Q9GZV9 Q9HCT0 Q9NP95 Q9UQC2 Q9Y4H2	AREG AREGB ARHG BCAP BDNF BTC CD135 CD19 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ESR ESR1 ESR2 ESTRB FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 FYN GAB1 GAB2 GGF GRB1 HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRGA HST HST2 HSTF1 HSTF2 HYPF INT2 IRS1 IRS2 JTK2 KGF KIAA0571 KIT KLB KS3 LAB7 LCK MET MLN19 NDF NEU NGL NR3A1 NR3A2 NRG1 NRG2 NRG3 NRG4 NTAK NTF3 NTF4 NTF5 NTRK2 NTRK3 PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PIK3AP1 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTP2C PTPN11 RAC1 RAC2 RHEPDGFRA RHOG SCFR SDGF SHPTP2 SIS SMDF SRC SRC1 STK1 STRN TC25 TCRIM TGFA TKF TRAT1 TRKB TRKC VAV VAV1	Homo sapiens (human)
tandutinib-resistant FLT3 mutants	Receptor-type tyrosine-protein kinase FLT3	P36888	CD135 FLK2 FLT3 STK1	Homo sapiens (human)
crenolanib-resistant FLT3 mutants	Receptor-type tyrosine-protein kinase FLT3	P36888	CD135 FLK2 FLT3 STK1	Homo sapiens (human)
MECP2 regulates transcription of neuronal ligands	Brain-derived neurotrophic factor Corticoliberin Delta-like protein 1 Histone deacetylase 1 Paired amphipathic helix protein Sin3a Somatostatin	O00548 P06850 P23560 P61278 Q13547 Q96ST3	BDNF CRH DLL1 HDAC1 RPD3L1 SIN3A SST	Homo sapiens (human)
Defective factor XII causes hereditary angioedema	Coagulation factor XII Plasma kallikrein Prothrombin	P00734 P00748 P03952	F12 F2 KLK3 KLKB1	Homo sapiens (human)
DDX58/IFIH1-mediated induction of interferon-alpha/beta	ATP-dependent RNA helicase DHX58 Antiviral innate immune response receptor RIG-I E3 ISG15--protein ligase HERC5 E3 ubiquitin-protein ligase RNF135 E3 ubiquitin-protein ligase TRIM4 E3 ubiquitin/ISG15 ligase TRIM25 Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Interferon regulatory factor 3 Interferon-induced helicase C domain-containing protein 1 Mitochondrial antiviral-signaling protein Mitochondrial import receptor subunit TOM70 NLR family member X1 Nucleoprotein ORF9b protein Protein NLRC5 Serine/threonine-protein kinase TBK1 Triokinase/FMN cyclase Ubiquitin-like modifier-activating enzyme 7 Ubiquitin-like protein ISG15 Ubiquitin/ISG15-conjugating enzyme E2 L6	O14933 O94826 O95786 P05161 P07900 P08238 P0DTC9 P0DTD2 P41226 Q14258 Q14653 Q3LXA3 Q7Z434 Q86UT6 Q86WI3 Q8IUD6 Q96C10 Q9BYX4 Q9C037 Q9UHD2 Q9UII4	9b CEB1 CEBP1 D11LGP2E DAK DDX58 DHX58 EFP G1P2 HERC5 HSP90A HSP90AA1 HSP90AB1 HSP90B HSPC1 HSPC2 HSPC3 HSPCA HSPCB IFIH1 IPS1 IRF3 ISG15 KIAA0719 KIAA1271 LGP2 MAVS MDA5 N NAK NLRC5 NLRX1 NOD27 NOD4 NOD5 NOD9 RH116 RIGI RNF135 RNF147 RNF87 TBK1 TKFC TOM70 TOMM70 TOMM70A TRIM25 TRIM4 UBA7 UBCH8 UBE1L UBE2 UBE2L6 UCRP VISA ZNF147	Homo sapiens (human)
Trafficking of myristoylated proteins to the cilium	ADP-ribosylation factor-like protein 3 Cystin-1 Nephrocystin-3 Protein XRP2 Protein unc-119 homolog B	A6NIH7 O75695 P36405 Q717R9 Q7Z494	ARFL3 ARL3 CYS1 KIAA2000 NPHP3 RP2 UNC119B	Homo sapiens (human)

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