GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **1601 - 1625** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
SLIT2:ROBO1 increases RHOA activity	Roundabout homolog 1 Slit homolog 2 protein Transforming protein RhoA Unconventional myosin-IXb	O94813 P61586 Q13459 Q9Y6N7	ARH12 ARHA DUTT1 MYO9B MYR5 RHO12 RHOA ROBO1 SLIL3 SLIT2	Homo sapiens (human)
Apoptosis induced DNA fragmentation	Caspase-3 DNA fragmentation factor subunit alpha DNA fragmentation factor subunit beta High mobility group protein B1 High mobility group protein B2 Histone H1.0 Histone H1.1 Histone H1.2 Histone H1.3 Histone H1.4 Histone H1.5 Importin subunit alpha-5 Importin subunit beta-1	O00273 O76075 P07305 P09429 P10412 P16401 P16402 P16403 P26583 P42574 P52294 Q02539 Q14974	CAD CASP3 CPP32 DFF1 DFF2 DFF40 DFF45 DFFA DFFB H1-0 H1-1 H1-2 H1-3 H1-4 H1-5 H1F0 H1F1 H1F2 H1F3 H1F4 H1F5 H1FV HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HMG1 HMG2 HMGB1 HMGB2 KPNA1 KPNB1 NTF97 RCH2	Homo sapiens (human)
Interleukin-20 family signaling	Interferon lambda receptor 1 Interferon lambda-1 Interferon lambda-2 Interferon lambda-3 Interleukin-10 receptor subunit beta Interleukin-19 Interleukin-20 receptor subunit alpha Interleukin-20 receptor subunit beta Interleukin-20 Interleukin-22 receptor subunit alpha-1 Interleukin-22 receptor subunit alpha-2 Interleukin-22 Interleukin-24 Interleukin-26 Non-receptor tyrosine-protein kinase TYK2 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 2 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 4 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3 Tyrosine-protein phosphatase non-receptor type 11	O60674 P23458 P29597 P40763 P42224 P42229 P51692 P52333 P52630 Q06124 Q08334 Q13007 Q14765 Q6UXL0 Q8IU54 Q8IU57 Q8IZI9 Q8IZJ0 Q8N6P7 Q969J5 Q9GZX6 Q9NPH9 Q9NYY1 Q9UHD0 Q9UHF4	AK155 APRF CRFB4 D21S58 D21S66 DIRS1 IFNL1 IFNL2 IFNL3 IFNLR1 IL10RB IL19 IL20 IL20RA IL20RB IL22 IL22R IL22RA1 IL22RA2 IL24 IL26 IL28A IL28B IL28C IL28RA IL29 ILTIF JAK1 JAK1A JAK1B JAK2 JAK3 LICR2 MDA7 PTP2C PTPN11 SHPTP2 ST16 STAT1 STAT2 STAT3 STAT4 STAT5 STAT5A STAT5B TYK2 ZCYTO10 ZCYTO18 ZCYTO20 ZCYTO21 ZCYTO22 ZMDA1	Homo sapiens (human)
lestaurtinib-resistant FLT3 mutants	Receptor-type tyrosine-protein kinase FLT3	P36888	CD135 FLK2 FLT3 STK1	Homo sapiens (human)
Signaling by MAP2K mutants	Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3	P27361 P28482 P36507 Q02750	ERK1 ERK2 MAP2K1 MAP2K2 MAPK1 MAPK3 MEK1 MEK2 MKK2 PRKM1 PRKM2 PRKM3 PRKMK1 PRKMK2	Homo sapiens (human)
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	Apoptotic protease-activating factor 1 Caspase-3 Caspase-7 Caspase-9 Cytochrome c Diablo IAP-binding mitochondrial protein E3 ubiquitin-protein ligase XIAP	O14727 P42574 P55210 P55211 P98170 P99999 Q9NR28	APAF1 API3 BIRC4 CASP3 CASP7 CASP9 CPP32 CYC CYCS DIABLO IAP3 KIAA0413 MCH3 MCH6 SMAC XIAP	Homo sapiens (human)
Downregulation of TGF-beta receptor signaling	BMP and activin membrane-bound inhibitor homolog E3 ubiquitin-protein ligase CHIP E3 ubiquitin-protein ligase NEDD4-like E3 ubiquitin-protein ligase SMURF1 E3 ubiquitin-protein ligase SMURF2 Exportin-1 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 7 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 Polyubiquitin-B Polyubiquitin-C Protein TMEPAI Protein phosphatase 1 regulatory subunit 15A Serine-threonine kinase receptor-associated protein Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta-1 proprotein Ubiquitin carboxyl-terminal hydrolase 15 Ubiquitin carboxyl-terminal hydrolase isozyme L5 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14980 O15105 O75807 P01137 P0CG47 P0CG48 P36873 P36897 P37173 P62136 P62140 P62979 P62987 P84022 Q13145 Q15796 Q969W9 Q96PU5 Q9HAU4 Q9HCE7 Q9NYA4 Q9UNE7 Q9Y3F4 Q9Y4E8 Q9Y5K5	ALK5 BAMBI CHIP CRM1 GADD34 KIAA0439 KIAA0529 KIAA0647 KIAA1625 MADH2 MADH3 MADH7 MADH8 MADR2 MAWD MTMR4 NEDD4L NEDL3 NMA PMEPA1 PPP1A PPP1CA PPP1CB PPP1CC PPP1R15A RPS27A SKR4 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STAG1 STRAP STUB1 TGFB TGFB1 TGFBR1 TGFBR2 TMEPAI UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UCH37 UCHL5 UNRIP USP15 XPO1 ZFYVE11	Homo sapiens (human)
Cardiogenesis	Catenin beta-1 Eomesodermin homolog Forkhead box protein O4 Hairy/enhancer-of-split related with YRPW motif protein 1 Hairy/enhancer-of-split related with YRPW motif protein 2 Heart- and neural crest derivatives-expressed protein 1 Heart- and neural crest derivatives-expressed protein 2 Histone acetyltransferase KAT2A Histone acetyltransferase KAT5 Histone-lysine N-methyltransferase SMYD1 Homeobox protein Nkx-2.5 Insulin gene enhancer protein ISL-1 LIM domain-binding protein 1 Lymphoid enhancer-binding factor 1 Mesoderm posterior protein 1 Mothers against decapentaplegic homolog 1 Mothers against decapentaplegic homolog 4 Myocardin Myocyte-specific enhancer factor 2C Serum response factor T-box transcription factor T T-box transcription factor TBX1 T-box transcription factor TBX20 T-box transcription factor TBX5 Transcription factor GATA-4 Transcription factor GATA-6 WD repeat-containing protein 5	O15178 O43435 O95936 O96004 P11831 P35222 P43694 P52952 P61296 P61371 P61964 P98177 Q06413 Q13485 Q15797 Q86U70 Q8IZQ8 Q8NB12 Q92830 Q92908 Q92993 Q99593 Q9BRJ9 Q9UBP5 Q9UJU2 Q9UMR3 Q9Y5J3	AFX AFX1 BHLHA26 BHLHA27 BHLHB31 BHLHB32 BHLHC5 BIG3 BSP1 CHF1 CHF2 CLIM2 CSX CTNNB CTNNB1 DHAND DPC4 EHAND EOMES FOXO4 GATA4 GATA6 GCN5 GCN5L2 GRL HAND1 HAND2 HERP HERP1 HERP2 HESR1 HEY1 HEY2 HRT1 HRT2 HTATIP ISL1 KAT2A KAT5 LDB1 LEF1 MADH1 MADH4 MADR1 MEF2C MESP1 MLLT7 MYCD MYOCD NKX2-5 NKX2.5 NKX2E SMAD1 SMAD4 SMYD1 SRF T TBR2 TBX1 TBX20 TBX5 TBXT TIP60 WDR5	Homo sapiens (human)
Regulation of IFNA/IFNB signaling	Interferon alpha-1/13 Interferon alpha-10 Interferon alpha-14 Interferon alpha-16 Interferon alpha-17 Interferon alpha-21 Interferon alpha-2 Interferon alpha-4 Interferon alpha-5 Interferon alpha-6 Interferon alpha-7 Interferon alpha-8 Interferon alpha/beta receptor 1 Interferon beta Non-receptor tyrosine-protein kinase TYK2 Signal transducer and activator of transcription 2 Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase JAK1 Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 6 Ubl carboxyl-terminal hydrolase 18	O14543 O15524 P01562 P01563 P01566 P01567 P01568 P01569 P01570 P01571 P01574 P05013 P05014 P05015 P17181 P18031 P23458 P29350 P29597 P32881 P52630 Q06124 Q9UMW8	CIS3 HCP IFB IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA2A IFNA2B IFNA2C IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR IFNAR1 IFNB IFNB1 ISG43 JAK1 JAK1A JAK1B PTP1B PTP1C PTP2C PTPN1 PTPN11 PTPN6 SHPTP2 SOCS1 SOCS3 SSI1 SSI3 STAT2 TIP3 TYK2 USP18	Homo sapiens (human)
Amyloid fiber formation	ADP-ribosylation factor-binding protein GGA1 ADP-ribosylation factor-binding protein GGA2 ADP-ribosylation factor-binding protein GGA3 Alpha-synuclein Amyloid-beta precursor protein Apolipoprotein A-I Apolipoprotein A-IV Apolipoprotein E Basement membrane-specific heparan sulfate proteoglycan core protein Beta-2-microglobulin Beta-secretase 1 Calbindin Calcitonin Cystatin-C Disintegrin and metalloproteinase domain-containing protein 10 E3 ubiquitin-protein ligase SIAH1 E3 ubiquitin-protein ligase SIAH2 E3 ubiquitin-protein ligase parkin Fibrinogen alpha chain Furin Gamma-secretase subunit APH-1A Gamma-secretase subunit APH-1B Gamma-secretase subunit PEN-2 Gelsolin Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.Z Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Insulin Integral membrane protein 2B Islet amyloid polypeptide Lactadherin Lactotransferrin Lysozyme C N-acetyltransferase 8 Natriuretic peptides A Nicastrin Odontogenic ameloblast-associated protein Polyubiquitin-B Polyubiquitin-C Prolactin Putative N-acetyltransferase 8B Semenogelin-1 Serum amyloid A-1 protein Serum amyloid P-component Sortilin-related receptor Synphilin-1 Tetraspanin-14 Tetraspanin-15 Tetraspanin-33 Tetraspanin-5 Transforming growth factor-beta-induced protein ig-h3 Transthyretin Ubiquitin carboxyl-terminal hydrolase 9X Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Ubiquitin/ISG15-conjugating enzyme E2 L6	A1E959 O14672 O14933 O43255 O60260 O60814 O95858 P01034 P01160 P01236 P01258 P01308 P02647 P02649 P02671 P02743 P02766 P02788 P04279 P04908 P05067 P05937 P06396 P06727 P06899 P09958 P0C0S5 P0C5Y9 P0CG47 P0CG48 P0DJI8 P10997 P16104 P20671 P23527 P33778 P37840 P56817 P57053 P58876 P61626 P61769 P62079 P62805 P62807 P62979 P62987 P68431 P84243 P98160 Q08431 Q15582 Q16777 Q16778 Q6FI13 Q71DI3 Q86UF1 Q8IUQ4 Q8N257 Q8NG11 Q8WW43 Q92542 Q92673 Q93008 Q93077 Q93079 Q96A08 Q96BI3 Q99877 Q99878 Q99879 Q99880 Q9NZ42 Q9NZ52 Q9UHE5 Q9UHF3 Q9UJY4 Q9UJY5 Q9Y287 Q9Y6H5	A4 AD1 ADAM10 ANP APCS APH1A APH1B APIN APOA1 APOA4 APOE APP B2M BACE BACE1 BIGH3 BRI BRI2 C11orf32 CAB27 CALB1 CALC1 CALCA CML1 CML2 CST3 DFFRX FAM FGA FUR FURIN GGA1 GGA2 GGA3 GIG12 GLA GSN H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFL H2AFM H2AFO H2AFQ H2AFX H2AFZ H2AX H2AZ H2AZ1 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 HSPG2 HUMSIAH IAPP INS ITM2B KIAA0154 KIAA0253 KIAA1080 KIAA1149 KUZ LF LTF LYZ LZM MADM MFGE8 NACP NAT8 NAT8B NCSTN NET7 NPPA ODAM PACE PALB PARK1 PARK2 PCSK3 PEN PEN2 PND PRKN PRL PSENEN PSF PSFL PTX2 RPS27A SAA1 SEMG SEMG1 SIAH1 SIAH2 SNCA SNCAIP SORL1 TGFBI TM4SF14 TM4SF15 TM4SF9 TSC501 TSH2B TSPAN14 TSPAN15 TSPAN33 TSPAN5 TTR UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBCH8 UBE2L6 USP9 USP9X	Homo sapiens (human)
Sema3A PAK dependent Axon repulsion	Cofilin-1 Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta LIM domain kinase 1 Neuropilin-1 Plexin-A1 Plexin-A2 Plexin-A3 Plexin-A4 Ras-related C3 botulinum toxin substrate 1 Semaphorin-3A Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Tyrosine-protein kinase Fes/Fps Tyrosine-protein kinase Fyn	O14786 O75051 O75914 P06241 P07332 P07900 P08238 P23528 P51805 P53667 P63000 Q13153 Q13177 Q14563 Q9HCM2 Q9UIW2	CFL CFL1 FES FPS FYN HSP90A HSP90AA1 HSP90AB1 HSP90B HSPC1 HSPC2 HSPC3 HSPCA HSPCB KIAA0463 KIAA1550 LIMK LIMK1 NOV NRP NRP1 OCT OPHN3 PAK1 PAK2 PAK3 PLXN1 PLXN2 PLXN4 PLXNA1 PLXNA2 PLXNA3 PLXNA4 PLXNA4A PLXNA4B RAC1 SEMA3A SEMAD SEX TC25 VEGF165R	Homo sapiens (human)
Regulation of MITF-M-dependent genes involved in DNA damage repair and senescence	DNA ligase 1 Telomerase reverse transcriptase	O14746 P18858	EST2 LIG1 TCS1 TERT TRT	Homo sapiens (human)
Activated NTRK2 signals through PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 BDNF/NT-3 growth factors receptor Brain-derived neurotrophic factor Neurotrophin-4	P19174 P23560 P34130 Q16620	BDNF NTF4 NTF5 NTRK2 PLC1 PLCG1 TRKB	Homo sapiens (human)
Synthesis of PIPs in the nucleus	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase	P48426 P78356 Q86T03 Q8TBX8	C14orf9 PI5P4KA PIP4K2A PIP4K2B PIP4K2C PIP4P1 PIP5K2 PIP5K2A PIP5K2B PIP5K2C TMEM55B	Homo sapiens (human)
Regulation of TP53 Activity through Association with Co-factors	Apoptosis-stimulating of p53 protein 1 Apoptosis-stimulating of p53 protein 2 Cellular tumor antigen p53 PHD finger protein 20 POU domain, class 4, transcription factor 1 POU domain, class 4, transcription factor 2 Protein BANP RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase RelA-associated inhibitor Tumor protein 63 Tumor protein p73 Zinc finger protein 385A	O15350 P04637 P31749 P31751 Q01851 Q12837 Q13625 Q8N9N5 Q8WUF5 Q96KQ4 Q96PM9 Q9BVI0 Q9H3D4 Q9Y243	AKT1 AKT2 AKT3 ASPP1 ASPP2 BANP BBP BEND1 BRN3A BRN3B C20orf104 GLEA2 HCA58 HZF IASPP KET KIAA0771 NKIP1 NZF P53 P63 P73 P73H P73L PHF20 PKB PKBG POU4F1 POU4F2 PPP1R13B PPP1R13BL PPP1R13L RAC RAI RDC1 RZF SMAR1 TP53 TP53BP2 TP63 TP73 TP73L TZP ZNF385 ZNF385A	Homo sapiens (human)
Ligand-independent caspase activation via DCC	Caspase-3 Caspase-9 DCC-interacting protein 13-alpha Death-associated protein kinase 1 Death-associated protein kinase 2 Death-associated protein kinase 3 Melanoma-associated antigen D1 Netrin receptor DCC Netrin receptor UNC5A Netrin receptor UNC5B	O43293 P42574 P43146 P53355 P55211 Q6ZN44 Q8IZJ1 Q9UIK4 Q9UKG1 Q9Y5V3	APPL APPL1 CASP3 CASP9 CPP32 DAPK DAPK1 DAPK2 DAPK3 DCC DIP13A IGDCC1 KIAA1428 KIAA1976 MAGED1 MCH6 NRAGE P53RDL1 UNC5A UNC5B UNC5H1 UNC5H2 ZIPK	Homo sapiens (human)
Antagonism of Activin by Follistatin	Follistatin-related protein 3 Follistatin Inhibin beta A chain Inhibin beta B chain	O95633 P08476 P09529 P19883	FLRG FST FSTL3 INHBA INHBB	Homo sapiens (human)
Defective OPLAH causes OPLAHD	5-oxoprolinase	O14841	OPLAH	Homo sapiens (human)
Presynaptic phase of homologous DNA pairing and strand exchange	26S proteasome complex subunit SEM1 ATR-interacting protein BRCA1-associated RING domain protein 1 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Breast cancer type 1 susceptibility protein Breast cancer type 2 susceptibility protein Cell cycle checkpoint control protein RAD9A Cell cycle checkpoint control protein RAD9B Cell cycle checkpoint protein RAD17 Cell cycle checkpoint protein RAD1 Checkpoint protein HUS1 DNA endonuclease RBBP8 DNA repair protein RAD50 DNA repair protein RAD51 homolog 1 DNA repair protein RAD51 homolog 2 DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 4 DNA repair protein XRCC2 DNA replication ATP-dependent helicase/nuclease DNA2 DNA topoisomerase 2-binding protein 1 DNA topoisomerase 3-alpha Double-strand break repair protein MRE11 Exonuclease 1 Fanconi anemia group J protein Histone acetyltransferase KAT5 Nibrin RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RecQ-like DNA helicase BLM RecQ-mediated genome instability protein 1 RecQ-mediated genome instability protein 2 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine-protein kinase ATM Serine/threonine-protein kinase ATR Serine/threonine-protein kinase Chk1	O14757 O15315 O43502 O43543 O60671 O60921 O60934 O75771 O75943 P15927 P27694 P35244 P35249 P35250 P38398 P40937 P40938 P49959 P51530 P51587 P54132 P60896 Q06609 Q13315 Q13472 Q13535 Q14191 Q6WBX8 Q8WXE1 Q92547 Q92878 Q92993 Q96E14 Q99638 Q99708 Q99728 Q9BSD3 Q9BX63 Q9H9A7 Q9UQ84	AGS1 ATM ATR ATRIP BACH1 BARD1 BLM BRCA1 BRCA2 BRIP1 C12orf32 C16orf75 C7orf76 C9orf76 CHEK1 CHK1 CTIP DNA2 DNA2L DSS1 EXO1 EXOI FACD FANCD1 FANCJ FRP1 HEX1 HNGS1 HTATIP HUS1 KAT5 KIAA0083 KIAA0259 MRE11 MRE11A NBN NBS NBS1 P95 R24L RAD1 RAD17 RAD50 RAD51 RAD51A RAD51B RAD51C RAD51D RAD51L1 RAD51L2 RAD51L3 RAD9A RAD9B RBBP8 REC1 REC2 RECA RECQ2 RECQ3 RECQL2 RECQL3 REPA1 REPA2 REPA3 RFC2 RFC3 RFC4 RFC5 RHINO RHNO1 RMI1 RMI2 RNF53 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 SEM1 SHFDG1 SHFM1 TIP60 TOP3 TOP3A TOPBP1 WRN XRCC2	Homo sapiens (human)
ERBB2 Activates PTK6 Signaling	Epidermal growth factor receptor Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein-tyrosine kinase 6 Receptor tyrosine-protein kinase erbB-2	O14511 O14944 P00533 P01133 P04626 P35070 P56975 Q02297 Q13882 Q8WWG1 Q99075	BRK BTC DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GGF HBEGF HEGFL HER1 HER2 HGL HRGA MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NTAK PTK6 SMDF	Homo sapiens (human)
Defective SLC33A1 causes spastic paraplegia 42 (SPG42)	Acetyl-coenzyme A transporter 1	O00400	ACATN AT1 SLC33A1	Homo sapiens (human)
Extrinsic Pathway of Fibrin Clot Formation	Coagulation factor IX Coagulation factor VII Coagulation factor X Tissue factor pathway inhibitor Tissue factor	P00740 P00742 P08709 P10646 P13726	F10 F3 F7 F9 LACI TFPI TFPI1	Homo sapiens (human)
Loss of phosphorylation of MECP2 at T308	Calcium/calmodulin-dependent protein kinase type IV Calmodulin-1 cAMP-dependent protein kinase catalytic subunit alpha	P0DP23 P17612 Q16566	CALM CALM1 CAM CAM1 CAMK CAMK-GR CAMK4 CAMKIV PKACA PRKACA	Homo sapiens (human)
Activation of the pre-replicative complex	Cell division control protein 45 homolog Cell division control protein 6 homolog Cell division cycle 7-related protein kinase Cyclin-dependent kinase 2 DNA helicase MCM8 DNA polymerase alpha catalytic subunit DNA polymerase alpha subunit B DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA primase large subunit DNA primase small subunit DNA replication factor Cdt1 DNA replication licensing factor MCM2 DNA replication licensing factor MCM3 DNA replication licensing factor MCM4 DNA replication licensing factor MCM5 DNA replication licensing factor MCM6 DNA replication licensing factor MCM7 Geminin Origin recognition complex subunit 1 Origin recognition complex subunit 2 Origin recognition complex subunit 3 Origin recognition complex subunit 4 Origin recognition complex subunit 5 Origin recognition complex subunit 6 Protein DBF4 homolog A Protein MCM10 homolog Replication protein A 14 kDa subunit Replication protein A 30 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit	O00311 O43913 O43929 O75419 O75496 P09884 P15927 P24941 P25205 P27694 P33991 P33992 P33993 P35244 P49642 P49643 P49736 P56282 Q07864 Q13156 Q13415 Q13416 Q14181 Q14566 Q7L590 Q99741 Q9H211 Q9NR33 Q9NRF9 Q9UBD5 Q9UBU7 Q9UJA3 Q9Y5N6	ASK BM28 C20orf154 CCNL1 CDC18L CDC21 CDC45 CDC45L CDC45L2 CDC46 CDC47 CDC6 CDC7 CDC7L1 CDCL1 CDK2 CDKN2 CDT1 CHRAC17 DBF4 DBF4A DPE2 GMNN KIAA0030 LATHEO MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC1L ORC2 ORC2L ORC3 ORC3L ORC4 ORC4L ORC5 ORC5L ORC6 ORC6L PARC1 POLA POLA1 POLA2 POLE POLE1 POLE2 POLE3 POLE4 PRIM1 PRIM2 PRIM2A REPA1 REPA2 REPA3 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA4 RPA70 ZDBF1	Homo sapiens (human)
NEP/NS2 Interacts with the Cellular Export Machinery	Aladin E3 SUMO-protein ligase RanBP2 Exportin-1 GTP-binding nuclear protein Ran Matrix protein 1 Nuclear envelope pore membrane protein POM 121 Nuclear envelope pore membrane protein POM 121C Nuclear export protein Nuclear pore complex protein Nup107 Nuclear pore complex protein Nup133 Nuclear pore complex protein Nup153 Nuclear pore complex protein Nup155 Nuclear pore complex protein Nup160 Nuclear pore complex protein Nup205 Nuclear pore complex protein Nup214 Nuclear pore complex protein Nup50 Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup88 Nuclear pore complex protein Nup93 Nuclear pore glycoprotein p62 Nuclear pore membrane glycoprotein 210 Nucleoporin NDC1 Nucleoporin NUP188 Nucleoporin NUP35 Nucleoporin NUP42 Nucleoporin Nup37 Nucleoporin Nup43 Nucleoporin p54 Nucleoprotein TPR Nucleoprotein Polymerase acidic protein Polymerase basic protein 2 Protein SEC13 homolog RNA-directed RNA polymerase catalytic subunit mRNA export factor RAE1	A8CG34 O14980 O15504 O75694 P03428 P03431 P03433 P03466 P03485 P03508 P12270 P35658 P37198 P49790 P49792 P55735 P57740 P62826 P78406 Q12769 Q5SRE5 Q7Z3B4 Q8N1F7 Q8NFH3 Q8NFH4 Q8NFH5 Q8TEM1 Q8WUM0 Q92621 Q96HA1 Q99567 Q9BTX1 Q9BW27 Q9NRG9 Q9UKX7	AAAS ADRACALA ARA24 C7orf14 CAIN CAN CG1 CRM1 D3S1231E KIAA0023 KIAA0095 KIAA0169 KIAA0197 KIAA0225 KIAA0618 KIAA0791 KIAA0906 M MP44 MRNP41 NDC1 NP NPAP60L NS NUP107 NUP120 NUP121 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP358 NUP37 NUP42 NUP43 NUP50 NUP53 NUP54 NUP62 NUP75 NUP85 NUP88 NUP93 NUPL2 PA PB1 PB2 PCNT1 POM121 POM121A POM121C RAE1 RAN RANBP2 SEC13 SEC13A SEC13L1 SEC13R TMEM48 TPR XPO1	Homo sapiens (human)

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