GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **751 - 775** of **2074** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism ▲	GlyTouCan ID
activated TAK1 mediates p38 MAPK activation	Dual specificity mitogen-activated protein kinase kinase 3 Dual specificity mitogen-activated protein kinase kinase 6 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase-like 2 MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Nucleotide-binding oligomerization domain-containing protein 1 Nucleotide-binding oligomerization domain-containing protein 2 Receptor-interacting serine/threonine-protein kinase 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	O43187 O43318 O43353 P46734 P49137 P51617 P52564 P61088 Q13404 Q15750 Q15759 Q16539 Q16644 Q8N5C8 Q9HC29 Q9NYJ8 Q9Y239 Q9Y4K3 Q9Y6K9	BLU CARD15 CARD4 CARDIAK CROC1 CSBP CSBP1 CSBP2 CSPB1 FIP3 IKBKG IRAK IRAK1 IRAK2 KIAA0733 MAP2K3 MAP2K6 MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 MAPK11 MAPK14 MAPKAPK2 MAPKAPK3 MEK3 MEK6 MKK3 MKK6 MXI2 NEMO NOD1 NOD2 PRKM11 PRKMK3 PRKMK6 RICK RIP2 RIPK2 RNF85 SAPK2 SAPK2A SAPK2B SKK2 SKK3 TAB1 TAB2 TAB3 TAK1 TRAF6 UBE2N UBE2V UBE2V1 UEV1	Homo sapiens (human)
Toll Like Receptor 7/8 (TLR7/8) Cascade	Toll-like receptor 7 Toll-like receptor 8	Q9NR97 Q9NYK1	TLR7 TLR8	Homo sapiens (human)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	Interferon regulatory factor 7 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Myeloid differentiation primary response protein MyD88 TNF receptor-associated factor 6 Toll-like receptor 7 Toll-like receptor 9 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	P51617 P61088 Q13404 Q92985 Q99836 Q9NR96 Q9NWZ3 Q9NYK1 Q9Y4K3	BLU CROC1 IRAK IRAK1 IRAK4 IRF7 MYD88 RNF85 TLR7 TLR9 TRAF6 UBE2N UBE2V UBE2V1 UEV1	Homo sapiens (human)
Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)	Chloride anion exchanger	P40879	DRA SLC26A3	Homo sapiens (human)
Defective MTR causes HMAG	Methionine synthase reductase Methionine synthase	Q99707 Q9UBK8	MTR MTRR	Homo sapiens (human)
Signaling by Hippo	14-3-3 protein beta/alpha 14-3-3 protein epsilon Angiomotin-like protein 1 Angiomotin-like protein 2 Caspase-3 MOB kinase activator 1A MOB kinase activator 1B Nephrocystin-4 Protein KIBRA Protein salvador homolog 1 Segment polarity protein dishevelled homolog DVL-2 Serine/threonine-protein kinase 3 Serine/threonine-protein kinase 4 Serine/threonine-protein kinase LATS1 Serine/threonine-protein kinase LATS2 Tight junction protein ZO-1 Tight junction protein ZO-2 Transcriptional coactivator YAP1 WW domain-containing transcription regulator protein 1	O14641 O75161 O95835 P31946 P42574 P46937 P62258 Q07157 Q13043 Q13188 Q7L9L4 Q8IX03 Q8IY63 Q9GZV5 Q9H4B6 Q9H8S9 Q9NRM7 Q9UDY2 Q9Y2J4	AMOTL1 AMOTL2 C2orf6 CASP3 CPP32 DVL2 KIAA0673 KIAA0869 KIAA0989 KIBRA KPM KRS1 KRS2 LATS1 LATS2 MOB1A MOB1B MOB4A MOB4B MOBK1B MOBKL1A MOBKL1B MST1 MST2 NPHP4 SAV1 STK3 STK4 TAZ TJP1 TJP2 WARTS WW45 WWC1 WWTR1 X104 YAP1 YAP65 YWHAB YWHAE ZO1 ZO2	Homo sapiens (human)
Regulation of TP53 Activity through Methylation	Cellular tumor antigen p53 E3 ubiquitin-protein ligase Mdm2 Histone acetyltransferase p300 Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Junction-mediating and -regulatory protein Lethal(3)malignant brain tumor-like protein 1 N-lysine methyltransferase KMT5A N-lysine methyltransferase SMYD2 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Protein arginine N-methyltransferase 5 SET domain-containing protein 9 Serine-protein kinase ATM Serine/threonine-protein kinase Chk2 Tetratricopeptide repeat protein 5 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14744 O15151 O96017 P04637 P0CG47 P0CG48 P62979 P62987 Q00987 Q09472 Q13315 Q8N0Z6 Q8N9B5 Q8NE22 Q96KQ7 Q9H9B1 Q9NQR1 Q9NRG4 Q9Y468	ATM BAT8 C5orf35 C6orf30 CDS1 CHEK2 CHK2 EHMT1 EHMT2 EP300 EUHMTASE1 G9A GLP HRMT1L5 IBP72 JBP1 JMY KIAA0681 KIAA1876 KMT1C KMT1D KMT3C KMT5A L3MBT L3MBTL L3MBTL1 MDM2 MDM4 MDMX NG36 P300 P53 PRMT5 PRSET7 RAD53 RPS27A SET07 SET8 SETD8 SETD9 SKB1 SMYD2 TP53 TTC5 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Signaling by LRP5 mutants	Dickkopf-related protein 1 Dickkopf-related protein 2 Dickkopf-related protein 4 Kremen protein 1 Kremen protein 2 Low-density lipoprotein receptor-related protein 5	O75197 O94907 Q8NCW0 Q96MU8 Q9UBT3 Q9UBU2	DKK1 DKK2 DKK4 KREMEN KREMEN1 KREMEN2 KRM1 KRM2 LR3 LRP5 LRP7	Homo sapiens (human)
Defective B3GALTL causes PpS	A disintegrin and metalloproteinase with thrombospondin motifs 10 A disintegrin and metalloproteinase with thrombospondin motifs 12 A disintegrin and metalloproteinase with thrombospondin motifs 13 A disintegrin and metalloproteinase with thrombospondin motifs 14 A disintegrin and metalloproteinase with thrombospondin motifs 15 A disintegrin and metalloproteinase with thrombospondin motifs 16 A disintegrin and metalloproteinase with thrombospondin motifs 17 A disintegrin and metalloproteinase with thrombospondin motifs 18 A disintegrin and metalloproteinase with thrombospondin motifs 19 A disintegrin and metalloproteinase with thrombospondin motifs 1 A disintegrin and metalloproteinase with thrombospondin motifs 20 A disintegrin and metalloproteinase with thrombospondin motifs 2 A disintegrin and metalloproteinase with thrombospondin motifs 3 A disintegrin and metalloproteinase with thrombospondin motifs 4 A disintegrin and metalloproteinase with thrombospondin motifs 5 A disintegrin and metalloproteinase with thrombospondin motifs 6 A disintegrin and metalloproteinase with thrombospondin motifs 7 A disintegrin and metalloproteinase with thrombospondin motifs 8 A disintegrin and metalloproteinase with thrombospondin motifs 9 ADAMTS-like protein 1 ADAMTS-like protein 2 ADAMTS-like protein 3 ADAMTS-like protein 4 ADAMTS-like protein 5 Beta-1,3-glucosyltransferase Properdin SCO-spondin Semaphorin-5A Semaphorin-5B Somatomedin-B and thrombospondin type-1 domain-containing protein Spondin-1 Spondin-2 Thrombospondin type-1 domain-containing protein 1 Thrombospondin type-1 domain-containing protein 4 Thrombospondin type-1 domain-containing protein 7A Thrombospondin type-1 domain-containing protein 7B Thrombospondin-1 Thrombospondin-2	A2VEC9 O15072 O75173 O95450 P07996 P27918 P35442 P58397 P59510 P82987 Q13591 Q6UY14 Q6Y288 Q6ZMM2 Q6ZMP0 Q76LX8 Q86TH1 Q8IVN8 Q8N6G6 Q8TE56 Q8TE57 Q8TE58 Q8TE59 Q8TE60 Q8WXS8 Q9BUD6 Q9C0I4 Q9H324 Q9HCB6 Q9NS62 Q9P283 Q9P2N4 Q9UHI8 Q9UKP4 Q9UKP5 Q9UNA0 Q9UP79 Q9UPZ6	ADAMTS1 ADAMTS10 ADAMTS11 ADAMTS12 ADAMTS13 ADAMTS14 ADAMTS15 ADAMTS16 ADAMTS17 ADAMTS18 ADAMTS19 ADAMTS2 ADAMTS20 ADAMTS21 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS6 ADAMTS7 ADAMTS8 ADAMTS9 ADAMTSL1 ADAMTSL2 ADAMTSL3 ADAMTSL4 ADAMTSL5 ADAMTSR1 ADMP2 B3GALTL B3GLCT B3GTL C8orf84 C9orf8 C9orf94 CFP DIL1 KIAA0366 KIAA0605 KIAA0688 KIAA0762 KIAA0960 KIAA1233 KIAA1312 KIAA1346 KIAA1445 KIAA1679 KIAA2029 KIAA2036 METH1 METH2 PCINP PCPNI PFC RPESP SBSPON SEMA5A SEMA5B SEMAF SEMAG SPON1 SPON2 SSPO SSPOP THBS1 THBS2 THSD1 THSD4 THSD6 THSD7A THSD7B TMTSP TSP TSP1 TSP2 TSRC1 VSGP	Homo sapiens (human)
Negative regulation of NMDA receptor-mediated neuronal transmission	Alpha-actinin-2 Calcium/calmodulin-dependent protein kinase type 1 Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calcium/calmodulin-dependent protein kinase type IV Calmodulin-1 Disks large homolog 1 Disks large homolog 2 Disks large homolog 3 Disks large homolog 4 Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2A Glutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic, NMDA 2D Leucine-rich repeat-containing protein 7 Neurofilament light polypeptide Protein phosphatase 1E Protein phosphatase 1F	O15399 P07196 P0DP23 P35609 P49593 P78352 Q05586 Q12879 Q12959 Q13224 Q13554 Q13555 Q13557 Q14012 Q14957 Q15700 Q16566 Q8WY54 Q92796 Q96NW7 Q9UQM7	ACTN2 CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-GR CAMK-II CAMK1 CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKA CAMKB CAMKD CAMKG CAMKIV CAMKN DLG1 DLG2 DLG3 DLG4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GluN2D KIAA0015 KIAA0968 KIAA1072 KIAA1232 KIAA1365 LAP1 LRRC7 NEFL NF68 NFL NMDAR1 NMDAR2A NMDAR2B NMDAR2C NMDAR2D POPX1 POPX2 PPM1E PPM1F PSD95	Homo sapiens (human)
Defective F8 cleavage by thrombin	Coagulation factor VIII Prothrombin von Willebrand factor	P00451 P00734 P04275	F2 F8 F8C F8VWF VWF	Homo sapiens (human)
SUMO is conjugated to E1 (UBA2:SAE1)	SUMO-activating enzyme subunit 1 SUMO-activating enzyme subunit 2 Small ubiquitin-related modifier 1 Small ubiquitin-related modifier 2 Small ubiquitin-related modifier 3	P55854 P61956 P63165 Q9UBE0 Q9UBT2	AOS1 SAE1 SAE2 SMT3A SMT3B SMT3C SMT3H1 SMT3H2 SMT3H3 SUA1 SUMO1 SUMO2 SUMO3 UBA2 UBL1 UBLE1A UBLE1B	Homo sapiens (human)
Lectin pathway of complement activation	Collectin-10 Collectin-11 Ficolin-1 Ficolin-2 Ficolin-3 Mannan-binding lectin serine protease 1 Mannose-binding protein C	O00602 O75636 P11226 P48740 Q15485 Q9BWP8 Q9Y6Z7	CLL1 COLEC1 COLEC10 COLEC11 CRARF CRARF1 FCN1 FCN2 FCN3 FCNH FCNL FCNM HAKA1 MASP1 MBL MBL2 PRSS5	Homo sapiens (human)	G49108TO G57321FI
RNA Polymerase I Transcription Termination	CDK-activating kinase assembly factor MAT1 Caveolae-associated protein 1 Cyclin-H Cyclin-dependent kinase 7 DNA-directed RNA polymerase I subunit RPA12 DNA-directed RNA polymerase I subunit RPA1 DNA-directed RNA polymerase I subunit RPA2 DNA-directed RNA polymerase I subunit RPA34 DNA-directed RNA polymerase I subunit RPA43 DNA-directed RNA polymerase I subunit RPA49 DNA-directed RNA polymerases I and III subunit RPAC1 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Nucleolar transcription factor 1 Protein POLR1D, isoform 2 TATA box-binding protein-associated factor RNA polymerase I subunit A TATA box-binding protein-associated factor RNA polymerase I subunit B TATA box-binding protein-associated factor RNA polymerase I subunit C TATA box-binding protein-associated factor RNA polymerase I subunit D TATA-box-binding protein Transcription termination factor 1	O15160 O15446 O95602 P0DPB5 P17480 P18074 P19388 P19447 P20226 P32780 P50613 P51946 P51948 P52434 P53803 P61218 P62875 Q13888 Q13889 Q15361 Q15572 Q15573 Q3B726 Q53T94 Q6NZI2 Q6ZYL4 Q92759 Q9GZS1 Q9H5J8 Q9H9Y6 Q9P1U0	ASE1 BTF2 BTF2P44 C6orf175 CAK CAK1 CAP35 CAST CAVIN1 CCNH CD3EAP CDK7 CDKN7 ERCC2 ERCC3 GTF2D1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 JOSD3 MAT1 MNAT1 MO15 PAF49 PAF53 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L POLRF PRAF1 PTRF RNF66 RPA12 STK1 TAF1A TAF1B TAF1C TAF1D TBP TF2D TFIID TTDA TTF1 TWISTNB UBF UBF1 UBTF XPB XPBC XPD XPDC ZNRD1	Homo sapiens (human)
Phosphorylation of CD3 and TCR zeta chains	HLA class II histocompatibility antigen, DP alpha 1 chain HLA class II histocompatibility antigen, DP beta 1 chain HLA class II histocompatibility antigen, DQ alpha 1 chain HLA class II histocompatibility antigen, DQ alpha 2 chain HLA class II histocompatibility antigen, DQ beta 1 chain HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DR alpha chain HLA class II histocompatibility antigen, DR beta 3 chain HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DRB1 beta chain Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Receptor-type tyrosine-protein phosphatase C Receptor-type tyrosine-protein phosphatase eta T cell receptor alpha chain constant T cell receptor alpha variable 19 T cell receptor alpha variable 29/delta variable 5 T cell receptor alpha variable 8-4 T cell receptor beta constant 1 T cell receptor beta variable 12-3 T cell receptor beta variable 7-9 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase CSK Tyrosine-protein kinase Lck Tyrosine-protein phosphatase non-receptor type 22	A0A0A6YYK7 P01730 P01733 P01737 P01848 P01850 P01903 P01906 P01909 P01911 P01920 P04234 P04435 P04437 P04440 P05538 P06239 P07766 P08575 P09693 P13762 P20036 P41240 P79483 Q12913 Q30154 Q9NWQ8 Q9Y2R2	CBP CD3D CD3E CD3G CD4 CD45 CSK DEP1 HLA-DP1A HLA-DP1B HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRA1 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-DXA HLA-DXB HLASB LCK PAG PAG1 PTPN22 PTPN8 PTPRC PTPRJ T3D T3E T3G TCRA TCRBV12S3 TCRBV8S1 TRAC TRAV19 TRAV29DV5 TRAV8-4 TRBC1 TRBV12-3 TRBV7-9	Homo sapiens (human)
GPVI-mediated activation cascade	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 3-phosphoinositide-dependent protein kinase 1 C-type lectin domain family 1 member B Cell division control protein 42 homolog Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 High affinity immunoglobulin epsilon receptor subunit gamma Linker for activation of T-cells family member 1 Lymphocyte cytosolic protein 2 Megakaryocyte and platelet inhibitory receptor G6b Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Phosphoinositide 3-kinase regulatory subunit 5 Phosphoinositide 3-kinase regulatory subunit 6 Platelet glycoprotein VI Podoplanin Protein kinase C zeta type Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoG Transforming protein RhoA Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6	O00459 O15530 O43561 O95866 P06239 P06241 P07948 P15153 P15498 P16885 P27986 P29350 P30273 P42336 P42338 P43405 P48736 P52735 P60953 P61586 P62745 P63000 P84095 Q05513 Q06124 Q13094 Q5UE93 Q86YL7 Q8WYR1 Q92569 Q9HCN6 Q9P126 Q9UKW4	ARH12 ARH6 ARHA ARHB ARHG C17orf38 C6orf25 CDC42 CLEC1B CLEC2 FCER1G FYN G6B G6B-B GP36 GP6 GRB1 HCP JTK8 LAT LCK LCP2 LYN MPIG6B PDK1 PDPK1 PDPN PIK3C1 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PKC2 PLCG2 PRKCZ PTP1C PTP2C PTPN11 PTPN6 RAC1 RAC2 RHO12 RHOA RHOB RHOG SHPTP2 SYK TC25 VAV VAV1 VAV2 VAV3	Homo sapiens (human)
Mitochondrial iron-sulfur cluster biogenesis	Adrenodoxin, mitochondrial Ferredoxin-2, mitochondrial Frataxin, mitochondrial Glutaredoxin-related protein 5, mitochondrial Iron-sulfur cluster assembly 1 homolog, mitochondrial Iron-sulfur cluster assembly 2 homolog, mitochondrial Iron-sulfur cluster co-chaperone protein HscB LYR motif-containing protein 4 Mitoferrin-1 Mitoferrin-2	P10109 Q16595 Q6P4F2 Q86SX6 Q86U28 Q8IWL3 Q96A46 Q9BUE6 Q9HD34 Q9NYZ2	ADX C14orf87 C6orf149 DNAJC20 FDX1 FDX1L FDX2 FRDA FXN GLRX5 HBLD1 HBLD2 HSC20 HSCB ISCA1 ISCA2 ISD11 LYRM4 MFRN MFRN2 MSCP SLC25A28 SLC25A37 X25	Homo sapiens (human)
Negative regulation of MAPK pathway	14-3-3 protein beta/alpha BRCA1-associated protein Dual specificity protein phosphatase 10 Dual specificity protein phosphatase 16 Dual specificity protein phosphatase 1 Dual specificity protein phosphatase 2 Dual specificity protein phosphatase 4 Dual specificity protein phosphatase 5 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Dual specificity protein phosphatase 8 Dual specificity protein phosphatase 9 GTPase HRas GTPase NRas Kinase suppressor of Ras 1 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Phosphatidylethanolamine-binding protein 1 Polyubiquitin-B Polyubiquitin-C Progestin and adipoQ receptor family member 3 RAF proto-oncogene serine/threonine-protein kinase Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase 5 Tyrosine-protein phosphatase non-receptor type 3 Tyrosine-protein phosphatase non-receptor type 7 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P01111 P01112 P04049 P0CG47 P0CG48 P10398 P15056 P26045 P27361 P27448 P28482 P28562 P30086 P30153 P30154 P31946 P35236 P53041 P53778 P62714 P62979 P62987 P67775 Q05923 Q13115 Q13202 Q13362 Q14738 Q15172 Q15173 Q16537 Q16690 Q16828 Q16829 Q6TCH7 Q7Z569 Q8IVT5 Q99956 Q9BY84 Q9Y6W6	ARAF ARAF1 BRAF BRAF1 BRAP C11orf81 CL100 CTAK1 DUSP1 DUSP10 DUSP16 DUSP2 DUSP4 DUSP5 DUSP6 DUSP7 DUSP8 DUSP9 EMK2 ERK1 ERK2 ERK6 HRAS HRAS1 KIAA0044 KIAA1700 KSR KSR1 MAPK1 MAPK12 MAPK3 MARK3 MKP1 MKP2 MKP3 MKP4 MKP5 MKP7 NRAS PAC1 PAQR3 PBP PEBP PEBP1 PKS PKS2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPP5 PPP5C PRKM1 PRKM2 PRKM3 PTPH1 PTPN10 PTPN3 PTPN7 PYST1 PYST2 RAF RAF1 RAFB1 RNF52 RPS27A SAPK3 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VH1 VH2 VH3 VH5 YWHAB	Homo sapiens (human)
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	Electrogenic sodium bicarbonate cotransporter 1	Q9Y6R1	NBC NBC1 NBCE1 SLC4A4	Homo sapiens (human)
Assembly of active LPL and LIPC lipase complexes	Angiopoietin-like protein 8 Angiopoietin-related protein 3 Angiopoietin-related protein 4 Apolipoprotein A-IV Apolipoprotein A-V Apolipoprotein C-II Cyclic AMP-responsive element-binding protein 3-like protein 3 Fibroblast growth factor 21 Furin Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 Hepatic triacylglycerol lipase Lipase maturation factor 1 Lipase maturation factor 2 Lipoprotein lipase Membrane-bound transcription factor site-1 protease Membrane-bound transcription factor site-2 protease Proprotein convertase subtilisin/kexin type 5 Proprotein convertase subtilisin/kexin type 6	O43462 P02655 P06727 P06858 P09958 P11150 P29122 Q14703 Q68CJ9 Q6Q788 Q6UXH0 Q8IV16 Q92824 Q96S06 Q9BU23 Q9BY76 Q9NSA1 Q9Y5C1	ANGPT5 ANGPTL3 ANGPTL4 ANGPTL8 APC2 APOA4 APOA5 APOC2 ARP4 C16orf26 C19orf80 CREB3L3 CREBH FGF21 FUR FURIN GPIHBP1 HBP1 HFARP HTGL KIAA0091 LIPC LIPD LMF1 LMF2 LPL MBTPS1 MBTPS2 PACE PACE4 PC5 PC6 PCSK3 PCSK5 PCSK6 PGAR RAP3 RIFL S1P S2P SKI1 TMEM112 TMEM112B TMEM153	Homo sapiens (human)
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	14-3-3 protein sigma Apoptosis regulator BAX Aurora kinase A Cellular tumor antigen p53 Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 Growth arrest and DNA damage-inducible protein GADD45 alpha Histone acetyltransferase p300 Histone-arginine methyltransferase CARM1 M-phase inducer phosphatase 3 Proliferating cell nuclear antigen Protein arginine N-methyltransferase 1 Retinoblastoma-like protein 1 Retinoblastoma-like protein 2 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F4 Zinc finger protein 385A	O14965 P04637 P06493 P12004 P14635 P24522 P28749 P30307 P31947 Q07812 Q08999 Q09472 Q14186 Q14188 Q16254 Q86X55 Q96PM9 Q99873	AIK AIRK1 ARK1 AURA AURKA AYK1 BAX BCL2L4 BTAK CARM1 CCNB CCNB1 CDC2 CDC25C CDC28A CDK1 CDKN1 DDIT1 DP1 DP2 E2F4 EP300 GADD45 GADD45A HME1 HMT2 HRMT1L2 HZF IAK1 IR1B4 P300 P34CDC2 P53 PCNA PRMT1 PRMT4 RB2 RBL1 RBL2 RZF SFN STK15 STK6 TFDP1 TFDP2 TP53 ZNF385 ZNF385A	Homo sapiens (human)
Phase 3 - rapid repolarisation	A-kinase anchor protein 9 Potassium voltage-gated channel subfamily A member 5 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily E member 3 Potassium voltage-gated channel subfamily E member 4 Potassium voltage-gated channel subfamily E regulatory beta subunit 5 Potassium voltage-gated channel subfamily KQT member 1 Voltage-gated inwardly rectifying potassium channel KCNH2	P15382 P22460 P51787 Q12809 Q8WWG9 Q99996 Q9UJ90 Q9Y6H6 Q9Y6J6	AKAP350 AKAP450 AKAP9 AMMECR2 ERG ERG1 HERG KCNA5 KCNA8 KCNA9 KCNE1 KCNE1L KCNE2 KCNE3 KCNE4 KCNE5 KCNH2 KCNQ1 KIAA0803 KVLQT1	Homo sapiens (human)
Interleukin receptor SHC signaling	Cytokine receptor common subunit beta Cytokine receptor common subunit gamma GRB2-associated-binding protein 2 Granulocyte-macrophage colony-stimulating factor receptor subunit alpha Granulocyte-macrophage colony-stimulating factor Interleukin-2 receptor subunit alpha Interleukin-2 receptor subunit beta Interleukin-2 Interleukin-3 receptor subunit alpha Interleukin-3 Interleukin-5 receptor subunit alpha Interleukin-5 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform SHC-transforming protein 1 Son of sevenless homolog 1 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3 Tyrosine-protein phosphatase non-receptor type 6	O00329 O00459 O15357 O60674 P01589 P04141 P05113 P08700 P14784 P15509 P23458 P26951 P27986 P29350 P29353 P31785 P32927 P42336 P42338 P52333 P60568 Q01344 Q07889 Q92569 Q92835 Q9UQC2	CSF2 CSF2R CSF2RA CSF2RB CSF2RY GAB2 GMCSF GRB1 HCP IL15RB IL2 IL2RA IL2RB IL2RG IL3 IL3R IL3RA IL3RB IL5 IL5R IL5RA IL5RB INPP5D INPPL1 JAK1 JAK1A JAK1B JAK2 JAK3 KIAA0571 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTP1C PTPN6 SHC SHC1 SHCA SHIP SHIP1 SHIP2 SOS1	Homo sapiens (human)
Estrogen-dependent gene expression	Apoptosis regulator Bcl-2 Axin-1 BTB/POZ domain-containing protein KCTD6 CREB-binding protein CXXC-type zinc finger protein 5 Cathepsin D Cbp/p300-interacting transactivator 1 Chromodomain-helicase-DNA-binding protein 1 Cohesin subunit SA-1 Cohesin subunit SA-2 Core-binding factor subunit beta Cyclic AMP-dependent transcription factor ATF-2 Cyclin-T1 Cyclin-dependent kinase 9 DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Double-strand-break repair protein rad21 homolog Estrogen receptor G1/S-specific cyclin-D1 General transcription factor IIF subunit 1 General transcription factor IIF subunit 2 Glycerol-3-phosphate acyltransferase 1, mitochondrial Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Helicase MOV-10 Hepatocyte nuclear factor 3-alpha Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone acetyltransferase KAT2B Histone acetyltransferase KAT5 Histone acetyltransferase p300 Histone deacetylase 1 Histone-arginine methyltransferase CARM1 Importin subunit alpha-1 KN motif and ankyrin repeat domain-containing protein 1 Lysine-specific demethylase 4B Lysine-specific histone demethylase 1A Mediator of RNA polymerase II transcription subunit 1 Myc proto-oncogene protein Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 3 Nuclear receptor subfamily 5 group A member 2 Nuclear receptor-interacting protein 1 POU domain, class 2, transcription factor 1 Peptidyl-prolyl cis-trans isomerase FKBP4 Probable ATP-dependent RNA helicase DDX5 Progesterone receptor Prostaglandin E synthase 3 Protein FosB Protein GREB1 Protein arginine N-methyltransferase 1 Protein argonaute-1 Protein argonaute-2 Protein argonaute-3 Protein argonaute-4 Protein c-Fos Protransforming growth factor alpha Receptor-binding cancer antigen expressed on SiSo cells Runt-related transcription factor 1 Stromal cell-derived factor 1 Structural maintenance of chromosomes protein 1A Structural maintenance of chromosomes protein 3 TATA-box-binding protein Trans-acting T-cell-specific transcription factor GATA-3 Transcription factor Jun Transcription factor JunD Transcription factor Sp1 Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA subunit 2 Transcriptional activator Myb Transcriptional repressor protein YY1 Transducin-like enhancer protein 3 Trefoil factor 1 Trefoil factor 3 Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein Upstream stimulatory factor 1 Upstream stimulatory factor 2 Zinc finger protein 217	O00482 O00559 O14646 O15169 O15514 O60216 O60341 O60563 O60814 O75362 O94953 P01100 P01106 P01135 P03372 P04155 P04908 P05412 P06401 P06899 P07339 P07900 P08047 P08238 P0C5Y9 P10242 P10415 P13984 P14859 P15336 P16104 P17535 P17844 P19387 P19388 P20226 P20671 P22415 P23527 P23771 P24385 P24928 P25490 P30876 P33778 P35269 P36954 P48061 P48552 P50750 P52292 P52434 P52435 P52655 P52657 P53539 P53803 P55317 P57053 P58876 P61218 P62487 P62805 P62807 P62875 P68431 P84243 Q01196 Q02790 Q04726 Q07654 Q09472 Q13547 Q13951 Q14678 Q14683 Q15185 Q15596 Q15648 Q15788 Q15853 Q16777 Q16778 Q4ZG55 Q6FI13 Q71DI3 Q71UI9 Q7LFL8 Q86X55 Q8N257 Q8N3U4 Q8NC69 Q8NDV7 Q8WVM7 Q92793 Q92831 Q92993 Q93077 Q93079 Q96A08 Q99873 Q99877 Q99878 Q99879 Q99880 Q99966 Q9BTM1 Q9H9G7 Q9HCE1 Q9HCJ0 Q9HCK5 Q9HCL2 Q9UKV8 Q9UL18 Q9UPQ9 Q9UQE7 Q9Y6Q9	AGO1 AGO2 AGO3 AGO4 AIB1 AML1 ANKRD15 AOF2 ARC205 ATF2 AXIN AXIN1 B1F BAM BCEI BCL1 BCL2 BHLHB11 BHLHB12 BHLHE39 BHLHE42 BHLHE74 BHLHE75 BMH CAGH26 CARM1 CBFA2 CBFB CBP CCND1 CCNT1 CDC2L4 CDK9 CHD1 CITED1 CPF CPSD CREB2 CREBBP CREBP1 CRSP1 CRSP200 CSPG6 CTSD CXCL12 CXXC5 DDX5 DRIP205 DRIP230 DXS423E EBAG9 EIF2C1 EIF2C2 EIF2C3 EIF2C4 EP300 ESR ESR1 FKBP4 FKBP52 FOS FOSB FOXA1 FTF G0S3 G0S7 G17P1 GATA3 GPAM GPAT1 GREB1 GTF2A1 GTF2A2 GTF2D1 GTF2F1 GTF2F2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HDAC1 HELR HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 HLR1 HMT2 HNF3A HR21 HRMT1L2 HSP90A HSP90AA1 HSP90AB1 HSP90B HSPC1 HSPC2 HSPC3 HSPCA HSPCB HTATIP INO80S IR1B4 ITF JHDM3B JMJD2B JUN JUND KANK KANK1 KAT2B KAT5 KCTD6 KDM1 KDM1A KDM4B KIAA0078 KIAA0172 KIAA0178 KIAA0575 KIAA0601 KIAA0876 KIAA1093 KIAA1460 KIAA1547 KIAA1560 KIAA1567 KIAA1582 KIAA1631 KPNA2 LSD1 MED1 MOV10 MSG1 MYB MYC NCOA1 NCOA2 NCOA3 NR3A1 NR3C3 NR5A2 NRIP1 NXP1 OCT1 OTF1 P23 P300 PBP PCAF PGR POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF POU2F1 PPARBP PPARGBP PRAD1 PRMT1 PRMT4 PS2 PTGES3 RAC3 RAD21 RAP30 RAP74 RB18A RCAS1 RCH1 RPB7 RPD3L1 RUNX1 SA1 SA2 SB1.8 SCC1 SCC3 SDF1 SDF1A SDF1B SMC1 SMC1A SMC1L1 SMC3 SMC3L1 SP1 SRC1 SRC2 SRP1 STAG1 STAG2 TAK TBP TCF3A TEBP TF2A1 TF2A2 TF2D TFF1 TFF3 TFI TFIID TGFA TIF2 TIP60 TLE3 TNRC6 TNRC6A TNRC6B TNRC6C TRAM1 TRAP220 TRIP2 TSFP1 TSH2B USF USF1 USF2 YY1 ZABC1 ZNF217	Homo sapiens (human)
Signaling by MST1	Hepatocyte growth factor-like protein Kunitz-type protease inhibitor 1 Kunitz-type protease inhibitor 2 Macrophage-stimulating protein receptor Serine protease hepsin	O43278 O43291 P05981 P26927 Q04912	D3F15S2 DNF15S2 HAI1 HAI2 HGFL HPN KOP MST1 MST1R PTK8 RON SPINT1 SPINT2 TMPRSS1	Homo sapiens (human)

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