GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **1501 - 1525** of **2074** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism
EGFR interacts with phospholipase C-gamma	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Amphiregulin Epidermal growth factor receptor Epigen Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha	O14944 P00533 P01133 P01135 P15514 P19174 P35070 Q6UW88 Q99075	AREG AREGB BTC DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG HBEGF HEGFL HER1 PLC1 PLCG1 SDGF TGFA	Homo sapiens (human)
EGFR downregulation	Amphiregulin Cell division control protein 42 homolog E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15-like 1 Epidermal growth factor receptor substrate 15 Epidermal growth factor receptor Epigen Epsin-1 Hepatocyte growth factor-regulated tyrosine kinase substrate Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein sprouty homolog 1 Protein sprouty homolog 2 Protransforming growth factor alpha Receptor-type tyrosine-protein phosphatase kappa Rho guanine nucleotide exchange factor 7 SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Tyrosine-protein phosphatase non-receptor type 12 Tyrosine-protein phosphatase non-receptor type 3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14944 O14964 O43597 O43609 O75886 P00533 P01133 P01135 P0CG47 P0CG48 P15514 P22681 P26045 P35070 P42566 P60953 P62979 P62987 Q05209 Q14155 Q15262 Q6UW88 Q92783 Q96B97 Q99075 Q99961 Q99962 Q99963 Q9UBC2 Q9Y6I3	AF1P AREG AREGB ARHGEF7 BTC CBL CBL2 CDC42 CIN85 CNSA1 CNSA2 CNSA3 COOL1 DTR DTS EGF EGFR EPGN EPN1 EPS15 EPS15L1 EPS15R ERBB ERBB1 EREG HBEGF HBP HEGFL HER1 HGS HRS KIAA0142 P85SPR PAK3BP PIXB PTPH1 PTPK PTPN12 PTPN3 PTPRK RNF55 RPS27A SDGF SH3D2A SH3D2B SH3D2C SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SPRY1 SPRY2 STAM STAM1 STAM2 TGFA UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
EGFR Transactivation by Gastrin	Epidermal growth factor receptor GTPase HRas GTPase NRas Proheparin-binding EGF-like growth factor Protein kinase C alpha type Son of sevenless homolog 1 Stromelysin-1	P00533 P01111 P01112 P08254 P17252 Q07889 Q99075	DTR DTS EGFR ERBB ERBB1 HBEGF HEGFL HER1 HRAS HRAS1 MMP3 NRAS PKCA PRKACA PRKCA SOS1 STMY1	Homo sapiens (human)
ECM proteoglycans	Aggrecan core protein Agrin Asporin Basement membrane-specific heparan sulfate proteoglycan core protein Biglycan Brevican core protein Cartilage matrix protein Cartilage oligomeric matrix protein Collagen alpha-1(IX) chain Collagen alpha-2(IX) chain Collagen alpha-3(IX) chain Decorin Dentin matrix acidic phosphoprotein 1 Dentin sialophosphoprotein Dystroglycan 1 Fibromodulin Hyaluronan and proteoglycan link protein 1 Integrin alpha-2 Integrin alpha-7 Integrin alpha-8 Integrin alpha-9 Integrin alpha-IIb Integrin alpha-V Integrin alpha-X Integrin beta-1 Integrin beta-3 Integrin beta-5 Integrin beta-6 Integrin-binding sialoprotein Laminin subunit alpha-1 Laminin subunit alpha-2 Laminin subunit alpha-3 Laminin subunit alpha-4 Laminin subunit alpha-5 Laminin subunit beta-1 Laminin subunit beta-2 Laminin subunit gamma-1 Low-density lipoprotein receptor-related protein 4 Lumican Matrilin-3 Matrilin-4 Muscle, skeletal receptor tyrosine-protein kinase Neural cell adhesion molecule 1 Neurocan core protein Plasminogen activator inhibitor 1 Receptor-type tyrosine-protein phosphatase S SPARC Tenascin-N Tenascin-R Tenascin-X Tenascin Transforming growth factor beta-1 proprotein Transforming growth factor beta-2 proprotein Transforming growth factor beta-3 proprotein Versican core protein Vitronectin	O00468 O14594 O15146 O15230 O15232 O75096 O95460 P01137 P04004 P05106 P05121 P05556 P06756 P07585 P07942 P08514 P09486 P10600 P10915 P11047 P13591 P13611 P16112 P17301 P18084 P18564 P20702 P20849 P21810 P21815 P21941 P22105 P24043 P24821 P25391 P49747 P51884 P53708 P55268 P61812 P98160 Q06828 Q13316 Q13332 Q13683 Q13797 Q14050 Q14055 Q14118 Q16363 Q16787 Q92752 Q96GW7 Q9BXN1 Q9NZW4 Q9UQP3	ACAN AGC1 AGRIN AGRN ASPN BCAN BEHAB BGN BNSP CD11C CD49B CMP COL9A1 COL9A2 COL9A3 COMP CRTL1 CRTM CSPG1 CSPG2 CSPG3 CSPG7 DAG1 DCN DMP1 DSPP FM FMOD FNRB GP2B GP3A HAPLN1 HSPG2 HXB HXBL IBSP ITGA2 ITGA2B ITGA7 ITGA8 ITGA9 ITGAB ITGAV ITGAX ITGB1 ITGB3 ITGB5 ITGB6 KIAA0533 KIAA0816 KIAA1907 LAMA LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMC1 LAMM LAMNA LAMS LDC LRP10 LRP4 LUM MATN1 MATN3 MATN4 MDF2 MEGF7 MSK12 MSK16 MSK8 MUSK NCAM NCAM1 NCAN NEUR ON PAI1 PLANH1 PLAP1 PTPRS SERPINE1 SLRR1A SLRR1B SLRR1C SLRR2D SLRR2E SPARC TGFB TGFB1 TGFB2 TGFB3 TNC TNN TNR TNW TNX TNXB TNXB1 TNXB2 VCAN VNRA VTN VTNR XB	Homo sapiens (human)
E3 ubiquitin ligases ubiquitinate target proteins	B-cell lymphoma/leukemia 10 DNA-dependent protein kinase catalytic subunit Derlin-1 E3 ubiquitin-protein ligase BRE1A E3 ubiquitin-protein ligase BRE1B E3 ubiquitin-protein ligase RAD18 E3 ubiquitin-protein ligase RNF144A E3 ubiquitin-protein ligase RNF152 E3 ubiquitin-protein ligase RNF181 E3 ubiquitin-protein ligase SHPRH E3 ubiquitin-protein ligase TM129 HLA class I histocompatibility antigen, A alpha chain Helicase-like transcription factor Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O MHC Class I antigen (B60) (Fragment) Parafibromin Peroxisomal membrane protein PEX13 Peroxisomal membrane protein PEX14 Peroxisome assembly protein 12 Peroxisome biogenesis factor 10 Peroxisome biogenesis factor 2 Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen RNA polymerase II-associated factor 1 homolog RNA polymerase-associated protein CTR9 homolog RNA polymerase-associated protein LEO1 RNA polymerase-associated protein RTF1 homolog Ras-related GTP-binding protein A Selenoprotein S Superkiller complex protein 8 Transitional endoplasmic reticulum ATPase Ubiquitin-conjugating enzyme E2 A Ubiquitin-conjugating enzyme E2 B Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 J2 Ubiquitin-conjugating enzyme E2 L3 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Unique short US11 glycoprotein WW domain-containing adapter protein with coiled-coil	A0AVI4 O00623 O60683 O60814 O75150 O75381 O95999 P04439 P06899 P09727 P0CG47 P0CG48 P12004 P23527 P28328 P33778 P49459 P50876 P51668 P51965 P55072 P58876 P61077 P61088 P62807 P62837 P62979 P62987 P63146 P68036 P78527 Q14527 Q149N8 Q15819 Q5VTR2 Q6P1J9 Q6PD62 Q7L523 Q8N2K1 Q8N7H5 Q8N8N0 Q8WVC0 Q92541 Q92968 Q93079 Q96A08 Q99877 Q99879 Q99880 Q9BQE4 Q9BTA9 Q9BUN8 Q9GZS3 Q9MY60 Q9NS91 Q9P0P0	BCL10 BLU BRE1A BRE1B C1orf28 CDC73 CIPER CLAP CTR9 DER1 DERL1 H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFR H2BFT HEL-220 HEL-S-70 HIP116A HIRIP1 HIRIP2 HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HLA-A HLA-B HLAA HLTF HRPT2 HYRC HYRC1 KIAA0155 KIAA0161 KIAA0252 KIAA0661 KIAA1844 KIAA2023 LEO1 MMS2 NCUBE2 PAF1 PAF3 PCNA PD2 PEX10 PEX12 PEX13 PEX14 PEX2 PMP3 PMP35 PRKDC PUBC1 PXMP3 RAD18 RAD6A RAD6B RDL RNF144 RNF144A RNF152 RNF181 RNF20 RNF40 RNF69 RNF72 RNF73 RNF80 RPS27A RRAGA RTF1 SELENOS SELS SFT SH2BP1 SHPRH SKIC8 SMARCA3 SNF2L3 TMEM129 TSH2B UBA52 UBA80 UBB UBC UBC4 UBC5A UBC5B UBC5C UBCE7 UBCE7IP4 UBCEP1 UBCEP2 UBCH1 UBCH4 UBCH5 UBCH5A UBCH5B UBCH5C UBCH6 UBCH7 UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2J2 UBE2L3 UBE2N UBE2V2 UEV2 US11 VCP VIMP WAC WDR61 ZBU1	Homo sapiens (human)
E2F-enabled inhibition of pre-replication complex formation	Cyclin-dependent kinase 1 DNA helicase MCM8 G2/mitotic-specific cyclin-B1 Origin recognition complex subunit 1 Origin recognition complex subunit 2 Origin recognition complex subunit 3 Origin recognition complex subunit 4 Origin recognition complex subunit 5 Origin recognition complex subunit 6	O43913 O43929 P06493 P14635 Q13415 Q13416 Q9UBD5 Q9UJA3 Q9Y5N6	C20orf154 CCNB CCNB1 CDC2 CDC28A CDK1 CDKN1 LATHEO MCM8 ORC1 ORC1L ORC2 ORC2L ORC3 ORC3L ORC4 ORC4L ORC5 ORC5L ORC6 ORC6L P34CDC2 PARC1	Homo sapiens (human)
Dual incision in TC-NER	CDK-activating kinase assembly factor MAT1 Cullin-4A Cullin-4B Cyclin-H Cyclin-dependent kinase 7 DNA damage-binding protein 1 DNA excision repair protein ERCC-1 DNA excision repair protein ERCC-5 DNA excision repair protein ERCC-6 DNA excision repair protein ERCC-8 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA polymerase kappa DNA repair endonuclease XPF DNA repair protein complementing XP-A cells DNA-directed RNA polymerase II subunit RPB11-a DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB3 DNA-directed RNA polymerase II subunit RPB4 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit RPB9 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 E3 ubiquitin-protein ligase RBX1 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Peptidyl-prolyl cis-trans isomerase E Polyubiquitin-B Polyubiquitin-C Pre-mRNA-processing factor 19 Pre-mRNA-splicing factor ISY1 homolog Pre-mRNA-splicing factor SYF1 Proliferating cell nuclear antigen RNA helicase aquarius Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Transcription elongation factor A protein 1 UV-stimulated scaffold protein A Ubiquitin carboxyl-terminal hydrolase 7 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Zinc finger protein 830	O15514 O60306 P07992 P0CG47 P0CG48 P12004 P15927 P18074 P19387 P19388 P19447 P23025 P23193 P24928 P27694 P28340 P28715 P30876 P32780 P35244 P35249 P35250 P35251 P36954 P40937 P40938 P49005 P50613 P51946 P51948 P52434 P52435 P53803 P56282 P61218 P62487 P62875 P62877 P62979 P62987 Q03468 Q07864 Q13216 Q13619 Q13620 Q13888 Q13889 Q15054 Q16531 Q2YD98 Q6ZYL4 Q92759 Q92889 Q93009 Q96NB3 Q9HCS7 Q9HCU8 Q9NR33 Q9NRF9 Q9UBT6 Q9ULR0 Q9UMS4 Q9UNP9	AQR BTF2 BTF2P44 C6orf175 CAK CAK1 CAP35 CCDC16 CCNH CDK7 CDKN7 CHRAC17 CKN1 CSA CSB CUL4A CUL4B CYP33 DDB1 DINB1 DPE2 ERCC1 ERCC11 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERCC8 ERCM2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2S HAUSP HCNP ISY1 KIAA0039 KIAA0560 KIAA0695 KIAA1160 KIAA1177 KIAA1530 MAT1 MNAT1 MO15 NMP200 PCNA POLD POLD1 POLD2 POLD3 POLD4 POLDS POLE POLE1 POLE2 POLE3 POLE4 POLK POLR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J1 POLR2K POLR2L POLRF PPIE PRP19 PRPF19 RBX1 REPA1 REPA2 REPA3 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RNF66 RNF75 ROC1 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPB7 RPS27A SNEV STK1 SYF1 TCEA1 TFIIS TTDA UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 USP7 UVSSA XAB2 XAP1 XPA XPAC XPB XPBC XPD XPDC XPF XPG XPGC ZNF830	Homo sapiens (human)
Dual Incision in GG-NER	Chromodomain-helicase-DNA-binding protein 1-like Cullin-4A Cullin-4B DNA damage-binding protein 1 DNA damage-binding protein 2 DNA excision repair protein ERCC-1 DNA excision repair protein ERCC-5 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA polymerase kappa DNA repair endonuclease XPF DNA repair protein complementing XP-A cells E3 ubiquitin-protein ligase RBX1 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Poly [ADP-ribose] polymerase 1 Poly [ADP-ribose] polymerase 2 Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P07992 P09874 P0CG47 P0CG48 P12004 P15927 P18074 P19447 P23025 P27694 P28340 P28715 P32780 P35244 P35249 P35250 P35251 P40937 P40938 P49005 P56282 P62877 P62979 P62987 Q07864 Q13619 Q13620 Q13888 Q13889 Q15054 Q16531 Q6ZYL4 Q86WJ1 Q92466 Q92759 Q92889 Q9HCU8 Q9NR33 Q9NRF9 Q9UBT6 Q9UGN5	ADPRT ADPRT2 ADPRTL2 ALC1 BTF2 BTF2P44 C6orf175 CHD1L CHRAC17 CUL4A CUL4B DDB1 DDB2 DINB1 DPE2 ERCC1 ERCC11 ERCC2 ERCC3 ERCC4 ERCC5 ERCM2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 KIAA0039 KIAA0695 PARP1 PARP2 PCNA POLD POLD1 POLD2 POLD3 POLD4 POLDS POLE POLE1 POLE2 POLE3 POLE4 POLK PPOL RBX1 REPA1 REPA2 REPA3 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RNF75 ROC1 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A TTDA UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 XAP1 XPA XPAC XPB XPBC XPD XPDC XPF XPG XPGC	Homo sapiens (human)
Drug-mediated inhibition of MET activation	Hepatocyte growth factor receptor Hepatocyte growth factor	P08581 P14210	HGF HPTA MET	Homo sapiens (human)
Drug-mediated inhibition of ERBB2 signaling	Erbin Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Receptor tyrosine-protein kinase erbB-2	P04626 P07900 Q16543 Q96RT1	CDC37 CDC37A ERBB2 ERBB2IP ERBIN HER2 HSP90A HSP90AA1 HSPC1 HSPCA KIAA1225 LAP2 MLN19 NEU NGL	Homo sapiens (human)
Drug resistance in ERBB2 TMD/JMD mutants	Erbin Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Receptor tyrosine-protein kinase erbB-2	P04626 P07900 Q16543 Q96RT1	CDC37 CDC37A ERBB2 ERBB2IP ERBIN HER2 HSP90A HSP90AA1 HSPC1 HSPCA KIAA1225 LAP2 MLN19 NEU NGL	Homo sapiens (human)
Downstream signaling of activated FGFR1	Fibroblast growth factor 10 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 Leucine-rich repeat transmembrane protein FLRT1 Leucine-rich repeat transmembrane protein FLRT2 Leucine-rich repeat transmembrane protein FLRT3	O15520 O43155 P05230 P08620 P09038 P10767 P11487 P31371 Q9GZV9 Q9HCT0 Q9NP95 Q9NZU0 Q9NZU1	FGF1 FGF10 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF9 FGFA FGFB FLRT1 FLRT2 FLRT3 HST HST2 HSTF1 HSTF2 HYPF INT2 KIAA0405 KIAA1469 KS3	Homo sapiens (human)
Downstream signal transduction	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Adapter molecule crk Breast cancer anti-estrogen resistance protein 1 Crk-like protein Cytoplasmic protein NCK2 GTPase HRas GTPase NRas Growth factor receptor-bound protein 7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Proto-oncogene tyrosine-protein kinase Src Rap guanine nucleotide exchange factor 1 Ras GTPase-activating protein 1 SH2/SH3 adapter protein NCK1 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Signal transducer and activator of transcription 6 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	O00459 O43639 P01111 P01112 P01127 P09619 P12931 P16234 P16333 P19174 P20936 P27986 P40763 P42224 P42226 P42229 P42336 P42338 P46108 P46109 P51692 P56945 Q06124 Q07889 Q13905 Q14451	APRF BCAR1 CAS CASS1 CRK CRKAS CRKL GAP GRB1 GRB4 GRB7 GRF2 HRAS HRAS1 NCK NCK1 NCK2 NRAS PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLC1 PLCG1 PTP2C PTPN11 RAPGEF1 RASA RASA1 RHEPDGFRA SHPTP2 SIS SOS1 SRC SRC1 STAT1 STAT3 STAT5 STAT5A STAT5B STAT6	Homo sapiens (human)
Downstream TCR signaling	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 3-phosphoinositide-dependent protein kinase 1 B-cell lymphoma/leukemia 10 Caspase recruitment domain-containing protein 11 Cullin-1 F-box/WD repeat-containing protein 11 F-box/WD repeat-containing protein 1A HLA class II histocompatibility antigen, DP alpha 1 chain HLA class II histocompatibility antigen, DP beta 1 chain HLA class II histocompatibility antigen, DQ alpha 1 chain HLA class II histocompatibility antigen, DQ alpha 2 chain HLA class II histocompatibility antigen, DQ beta 1 chain HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DR alpha chain HLA class II histocompatibility antigen, DR beta 3 chain HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DRB1 beta chain Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Mitogen-activated protein kinase kinase kinase 7 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 NF-kappa-B essential modulator NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p105 subunit Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Polyubiquitin-B Polyubiquitin-C Proteasomal ubiquitin receptor ADRM1 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Protein kinase C theta type Receptor-interacting serine/threonine-protein kinase 2 S-phase kinase-associated protein 1 T cell receptor alpha chain constant T cell receptor alpha variable 19 T cell receptor alpha variable 29/delta variable 5 T cell receptor alpha variable 8-4 T cell receptor beta constant 1 T cell receptor beta variable 12-3 T cell receptor beta variable 7-9 T-cell receptor-associated transmembrane adapter 1 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TNF receptor-associated factor 6 Transcription factor p65 Tyrosine-protein kinase Lck Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 R1 Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A0A6YYK7 O00231 O00232 O00459 O00487 O14818 O14920 O15111 O15530 O43242 O43318 O43353 O95999 P01730 P01733 P01737 P01848 P01850 P01903 P01906 P01909 P01911 P01920 P04234 P04435 P04437 P04440 P05538 P06239 P07766 P09693 P0CG47 P0CG48 P13762 P17980 P19838 P20036 P20618 P25786 P25787 P25788 P25789 P25963 P27986 P28066 P28070 P28072 P28074 P35998 P42336 P42338 P43686 P48556 P49427 P49720 P49721 P51665 P51668 P60484 P60896 P60900 P61088 P62191 P62195 P62333 P62837 P62979 P62987 P63208 P79483 Q04206 Q04759 Q13200 Q13404 Q13616 Q15008 Q16186 Q30154 Q6PIZ9 Q92835 Q99436 Q99460 Q9BXL7 Q9NYJ8 Q9UDY8 Q9UKB1 Q9UNM6 Q9Y297 Q9Y4K3 Q9Y6K9	ADRM1 BCL10 BLU BTRC BTRCP BTRCP2 C7orf76 CARD11 CARDIAK CARMA1 CD3D CD3E CD3G CD4 CDC34 CHUK CIPER CLAP CROC1 CUL1 DSS1 EMC19 FBW1A FBW1B FBXW11 FBXW1A FBXW1B FIP3 GP110 GRB1 HC2 HC3 HC8 HC9 HLA-DP1A HLA-DP1B HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRA1 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-DXA HLA-DXB HLASB HSPC IKBA IKBKB IKBKG IKKA IKKB INPP5D KIAA0107 KIAA0696 KIAA0733 LCK LMPX LMPY MAD3 MALT1 MAP3K7 MAP3K7IP2 MB1 MIP224 MLT MMAC1 MOV34L MSS1 NEMO NFKB1 NFKB3 NFKBI NFKBIA NU OCP2 PDK1 PDPK1 PFAAP4 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 POH1 PRKCQ PRKCT PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTEN PUBC1 RELA RICK RIP2 RIPK2 RNF85 RPS27A SEM1 SFT SHFDG1 SHFM1 SHIP SHIP1 SKP1 SKP1A SUG1 SUG2 T3D T3E T3G TAB2 TAK1 TBP1 TBP7 TCEB1L TCF16 TCRA TCRBV12S3 TCRBV8S1 TCRIM TEP1 TRAC TRAF6 TRAP2 TRAT1 TRAV19 TRAV29DV5 TRAV8-4 TRBC1 TRBV12-3 TRBV7-9 UBA52 UBA80 UBB UBC UBC4 UBC5A UBC5B UBCEP1 UBCEP2 UBCH3 UBCH4 UBCH5 UBCH5A UBCH5B UBE2D1 UBE2D2 UBE2N UBE2R1 UBE2V UBE2V1 UEV1 X Y Z	Homo sapiens (human)
Downregulation of TGF-beta receptor signaling	BMP and activin membrane-bound inhibitor homolog E3 ubiquitin-protein ligase CHIP E3 ubiquitin-protein ligase NEDD4-like E3 ubiquitin-protein ligase SMURF1 E3 ubiquitin-protein ligase SMURF2 Exportin-1 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 7 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 Polyubiquitin-B Polyubiquitin-C Protein TMEPAI Protein phosphatase 1 regulatory subunit 15A Serine-threonine kinase receptor-associated protein Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta-1 proprotein Ubiquitin carboxyl-terminal hydrolase 15 Ubiquitin carboxyl-terminal hydrolase isozyme L5 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14980 O15105 O75807 P01137 P0CG47 P0CG48 P36873 P36897 P37173 P62136 P62140 P62979 P62987 P84022 Q13145 Q15796 Q969W9 Q96PU5 Q9HAU4 Q9HCE7 Q9NYA4 Q9UNE7 Q9Y3F4 Q9Y4E8 Q9Y5K5	ALK5 BAMBI CHIP CRM1 GADD34 KIAA0439 KIAA0529 KIAA0647 KIAA1625 MADH2 MADH3 MADH7 MADH8 MADR2 MAWD MTMR4 NEDD4L NEDL3 NMA PMEPA1 PPP1A PPP1CA PPP1CB PPP1CC PPP1R15A RPS27A SKR4 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STAG1 STRAP STUB1 TGFB TGFB1 TGFBR1 TGFBR2 TMEPAI UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UCH37 UCHL5 UNRIP USP15 XPO1 ZFYVE11	Homo sapiens (human)
Downregulation of SMAD2/3:SMAD4 transcriptional activity	E3 ubiquitin-protein ligase Arkadia E3 ubiquitin-protein ligase NEDD4-like E3 ubiquitin-protein ligase SMURF2 E3 ubiquitin-protein ligase TRIM33 Histone deacetylase 1 Homeobox protein TGIF1 Homeobox protein TGIF2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Mothers against decapentaplegic homolog 7 Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Poly [ADP-ribose] polymerase 1 Polyubiquitin-B Polyubiquitin-C Protein ATP1B4 Protein phosphatase 1A SNW domain-containing protein 1 Ski oncogene Ski-like protein Ubiquitin carboxyl-terminal hydrolase 9X Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein WW domain-containing transcription regulator protein 1	O15105 O75376 P09874 P0CG47 P0CG48 P12755 P12757 P27361 P28482 P35813 P51668 P61077 P62979 P62987 P84022 Q13485 Q13547 Q13573 Q15583 Q15796 Q6ZNA4 Q93008 Q96PU5 Q9GZN2 Q9GZV5 Q9HAU4 Q9UN42 Q9UPN9 Q9Y618	ADPRT ATP1B4 CTG26 DFFRX DPC4 ERK1 ERK2 FAM HDAC1 KIAA0439 KIAA1047 KIAA1113 MADH2 MADH3 MADH4 MADH7 MADH8 MADR2 MAPK1 MAPK3 NCOR1 NCOR2 NEDD4L NEDL3 PARP1 PPM1A PPOL PPPM1A PRKM1 PRKM2 PRKM3 RFG7 RNF111 RPD3L1 RPS27A SFT SKI SKIIP SKIL SKIP SMAD2 SMAD3 SMAD4 SMAD7 SMURF2 SNO SNW1 TAZ TGIF TGIF1 TGIF2 TIF1G TRIM33 UBA52 UBA80 UBB UBC UBC5A UBC5C UBCEP1 UBCEP2 UBCH5 UBCH5A UBCH5C UBE2D1 UBE2D3 USP9 USP9X WWTR1	Homo sapiens (human)
Downregulation of ERBB4 signaling	E3 ubiquitin-protein ligase Itchy homolog E3 ubiquitin-protein ligase NEDD4 NEDD4-like E3 ubiquitin-protein ligase WWP1 Polyubiquitin-B Polyubiquitin-C Proto-oncogene tyrosine-protein kinase Src Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG47 P0CG48 P12931 P46934 P62979 P62987 Q96J02 Q9H0M0	ITCH KIAA0093 NEDD4 NEDD4-1 RPF1 RPS27A SRC SRC1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WWP1	Homo sapiens (human)
Downregulation of ERBB2:ERBB3 signaling	E3 ubiquitin-protein ligase NRDP1 Polyubiquitin-B Polyubiquitin-C Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor tyrosine-protein kinase erbB-2 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14511 P04626 P0CG47 P0CG48 P31749 P31751 P40818 P62979 P62987 Q02297 Q9H4P4 Q9Y243	AKT1 AKT2 AKT3 ERBB2 FLRF GGF HER2 HGL HRGA KIAA0055 MLN19 NDF NEU NGL NRDP1 NRG1 NRG2 NTAK PKB PKBG RAC RNF41 RPS27A SMDF UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBPY USP8	Homo sapiens (human)
Downregulation of ERBB2 signaling	Cullin-5 E3 ubiquitin-protein ligase CHIP Epidermal growth factor receptor Erbin Heat shock protein HSP 90-alpha Hsp90 co-chaperone Cdc37 Megakaryocyte-associated tyrosine-protein kinase Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Receptor tyrosine-protein kinase erbB-2 Tyrosine-protein phosphatase non-receptor type 12 Tyrosine-protein phosphatase non-receptor type 18 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14511 O14944 P00533 P01133 P04626 P07900 P0CG47 P0CG48 P35070 P42679 P56975 P62979 P62987 Q02297 Q05209 Q16543 Q8WWG1 Q93034 Q96RT1 Q99075 Q99952 Q9UNE7	BDP1 BTC CDC37 CDC37A CHIP CTK CUL5 DTR DTS EGF EGFR ERBB ERBB1 ERBB2 ERBB2IP ERBIN EREG GGF HBEGF HEGFL HER1 HER2 HGL HRGA HSP90A HSP90AA1 HSPC1 HSPCA HYL KIAA1225 LAP2 MATK MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NTAK PTPN12 PTPN18 RPS27A SMDF STUB1 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VACM1	Homo sapiens (human)
Dopamine receptors	D(1A) dopamine receptor D(1B) dopamine receptor D(2) dopamine receptor D(3) dopamine receptor D(4) dopamine receptor	P14416 P21728 P21917 P21918 P35462	DRD1 DRD1B DRD1L2 DRD2 DRD3 DRD4 DRD5	Homo sapiens (human)
Dopamine Neurotransmitter Release Cycle	Amyloid-beta A4 precursor protein-binding family A member 1 Complexin-1 Liprin-alpha-1 Liprin-alpha-2 Liprin-alpha-3 Liprin-alpha-4 Peripheral plasma membrane protein CASK Peripheral-type benzodiazepine receptor-associated protein 1 Protein lin-7 homolog A Protein lin-7 homolog B Protein lin-7 homolog C Protein unc-13 homolog B Ras-related protein Rab-3A Regulating synaptic membrane exocytosis protein 1 Synapsin-1 Synapsin-2 Synapsin-3 Synaptic vesicular amine transporter Synaptosomal-associated protein 25 Synaptotagmin-1 Syntaxin-1A Vesicle-associated membrane protein 2	O14795 O14810 O14910 O14936 O14994 O75145 O75334 O75335 O95153 P17600 P20336 P21579 P60880 P63027 Q02410 Q05940 Q13136 Q16623 Q86UR5 Q92777 Q9HAP6 Q9NUP9	APBA1 BZRAP1 CASK CPLX1 KIAA0340 KIAA0612 KIAA0654 KIAA0897 LIN2 LIN7A LIN7B LIN7C LIP1 MALS1 MALS2 MALS3 MINT1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RAB3IP2 RBP1 RIM1 RIMBP1 RIMS1 SLC18A2 SNAP SNAP25 STX1 STX1A SVMT SVP65 SYB2 SYN1 SYN2 SYN3 SYT SYT1 TSPOAP1 UNC13 UNC13B VAMP2 VELI1 VELI2 VELI3 VMAT2 X11	Homo sapiens (human)
Dissolution of Fibrin Clot	Alpha-2-antiplasmin Annexin A2 Glia-derived nexin Histidine-rich glycoprotein Plasminogen activator inhibitor 1 Plasminogen activator inhibitor 2 Plasminogen Protein S100-A10 Serpin B6 Serpin B8 Tissue-type plasminogen activator Urokinase plasminogen activator surface receptor Urokinase-type plasminogen activator	P00747 P00749 P00750 P04196 P05120 P05121 P07093 P07355 P08697 P35237 P50452 P60903 Q03405	AAP ANX2 ANX2L4 ANX2LG ANXA2 CAL1H CAL1L CLP11 HRG LPC2D MO3 PAI1 PAI2 PI6 PI7 PI8 PLANH1 PLANH2 PLAT PLAU PLAUR PLG PLI PN1 PTI S100A10 SERPINB2 SERPINB6 SERPINB8 SERPINE1 SERPINE2 SERPINF2 UPAR	Homo sapiens (human)
Displacement of DNA glycosylase by APEX1	DNA repair nuclease/redox regulator APEX1 DNA-3-methyladenine glycosylase Endonuclease III-like protein 1 G/T mismatch-specific thymine DNA glycosylase Methyl-CpG-binding domain protein 4 N-glycosylase/DNA lyase Single-strand selective monofunctional uracil DNA glycosylase	O15527 O95243 P27695 P29372 P78549 Q13569 Q53HV7	AAG ANPG APE APE1 APEX APEX1 APX HAP1 MBD4 MED1 MID1 MMH MPG MUTM NTH1 NTHL1 OCTS3 OGG1 OGH1 REF1 SMUG1 TDG	Homo sapiens (human)
Disinhibition of SNARE formation	Protein kinase C alpha type Protein kinase C beta type Protein kinase C gamma type Syntaxin-4 Syntaxin-binding protein 3	O00186 P05129 P05771 P17252 Q12846	PKCA PKCB PKCG PRKACA PRKCA PRKCB PRKCB1 PRKCG STX4 STX4A STXBP3	Homo sapiens (human)
Disassembly of the destruction complex and recruitment of AXIN to the membrane	APC membrane recruitment protein 1 Adenomatous polyposis coli protein Axin-1 Casein kinase I isoform alpha Casein kinase I isoform gamma-2 Catenin beta-1 Caveolin-1 Frizzled-1 Frizzled-2 Frizzled-5 GSK-3-binding protein FRAT2 Glycogen synthase kinase-3 beta Low-density lipoprotein receptor-related protein 5 Low-density lipoprotein receptor-related protein 6 Protein Wnt-3a Protein Wnt-8a Protein Wnt-8b Proto-oncogene FRAT1 Proto-oncogene Wnt-1 Segment polarity protein dishevelled homolog DVL-1 Segment polarity protein dishevelled homolog DVL-2 Segment polarity protein dishevelled homolog DVL-3 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	O14640 O14641 O15169 O75197 O75474 O75581 P04628 P25054 P30153 P30154 P35222 P48729 P49841 P56704 P62714 P67775 P78368 Q03135 Q13362 Q13467 Q14332 Q14738 Q15172 Q15173 Q16537 Q5JTC6 Q92837 Q92997 Q93098 Q9H1J5 Q9UP38	AMER1 APC AXIN AXIN1 C2orf31 CAV CAV1 CK1G2 CSNK1A1 CSNK1G2 CTNNB CTNNB1 DP2.5 DVL1 DVL2 DVL3 FAM123B FRAT1 FRAT2 FZD1 FZD2 FZD5 GSK3B INT1 KIAA0044 KIAA0208 LR3 LRP5 LRP6 LRP7 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WNT1 WNT3A WNT8A WNT8B WNT8D WTX	Homo sapiens (human)

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