GlyCosmos Portal

Homo sapiens (human)

Summary

Taxonomy ID: 9606
PubChem Taxonomy: 9606

Genes (1582) Glycans (5831) Glycoproteins (18496) Lectins (298) Pathways (2090)

Displaying entries **1426 - 1450** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▼
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 Docking protein 1 E3 ubiquitin-protein ligase CBL Polyubiquitin-B Polyubiquitin-C Protein-tyrosine kinase 6 RAC-alpha serine/threonine-protein kinase Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	P0CG47 P0CG48 P22681 P31749 P62979 P62987 Q13882 Q96P48 Q99704	AKT1 ARAP1 BRK CBL CBL2 CENTD2 DOK1 KIAA0782 PKB PTK6 RAC RNF55 RPS27A UBA52 UBA80 UBB UBC UBCEP1 UBCEP2
eNOS activation	Acyl-protein thioesterase 1 Calmodulin-1 Caveolin-1 Cytoglobin Heat shock protein HSP 90-alpha N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Nitric oxide synthase 3 Palmitoyltransferase ZDHHC21 RAC-alpha serine/threonine-protein kinase Sepiapterin reductase	O75608 O94760 P07900 P0DP23 P29474 P31749 P35270 Q03135 Q8IVQ6 Q8WWM9	AKT1 APT1 CALM CALM1 CAM CAM1 CAV CAV1 CYGB DDAH DDAH1 HSP90A HSP90AA1 HSPC1 HSPCA LPL1 LYPLA1 NOS3 PKB RAC SPR STAP ZDHHC21
Integrin signaling	3-phosphoinositide-dependent protein kinase 1 Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin Focal adhesion kinase 1 Integrin alpha-IIb Integrin beta-3 Proto-oncogene tyrosine-protein kinase Src RAC-alpha serine/threonine-protein kinase RAS guanyl-releasing protein 1 RAS guanyl-releasing protein 2 Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 Ras-related protein Rap-1A Ras-related protein Rap-1b SHC-transforming protein 1 Talin-1 Tyrosine-protein kinase CSK Tyrosine-protein kinase SYK Tyrosine-protein phosphatase non-receptor type 1 von Willebrand factor	O15530 O95267 O95398 P02671 P02675 P02679 P02751 P04275 P05106 P08514 P12931 P18031 P29353 P31749 P41240 P43405 P61224 P62834 Q05397 Q7LDG7 Q7Z5R6 Q8WZA2 Q9Y490	AKT1 APBB1IP CDC25L CGEF1 CGEF2 CSK EPAC EPAC1 EPAC2 F8VWF FAK FAK1 FGA FGB FGG FN FN1 GP2B GP3A ITGA2B ITGAB ITGB3 KIAA1027 KREV1 MCG7 PDK1 PDPK1 PKB PREL1 PTK2 PTP1B PTPN1 RAC RAP1A RAP1B RAPGEF3 RAPGEF4 RARP1 RASGRP RASGRP1 RASGRP2 RIAM SHC SHC1 SHCA SRC SRC1 SYK TLN TLN1 VWF
Interleukin-4 and Interleukin-13 signaling	72 kDa type IV collagenase Amine oxidase [flavin-containing] A Annexin A1 Apoptosis regulator Bcl-2 B-cell lymphoma 6 protein Baculoviral IAP repeat-containing protein 5 Basic leucine zipper transcriptional factor ATF-like Bcl-2-like protein 1 C-C motif chemokine 22 C-C motif chemokine 2 CCAAT/enhancer-binding protein delta Cellular tumor antigen p53 Coagulation factor XIII A chain Collagen alpha-2(I) chain Cyclin-dependent kinase inhibitor 1 Cytokine receptor common subunit gamma Delta-type opioid receptor Endoplasmin Eotaxin Fascin Fibroblast growth factor 2 Fibronectin Forkhead box protein O1 Forkhead box protein O3 G1/S-specific cyclin-D1 Heat shock cognate 71 kDa protein Heat shock protein HSP 90-alpha Heme oxygenase 1 Hepatocyte growth factor Homeobox protein NANOG Hypoxia-inducible factor 1-alpha Immunoglobulin heavy constant epsilon Immunoglobulin heavy constant gamma 1 Immunoglobulin heavy constant gamma 4 Induced myeloid leukemia cell differentiation protein Mcl-1 Integrin alpha-M Integrin alpha-X Integrin beta-1 Integrin beta-2 Intercellular adhesion molecule 1 Interferon regulatory factor 4 Interleukin-1 alpha Interleukin-1 beta Interleukin-10 Interleukin-12 subunit alpha Interleukin-12 subunit beta Interleukin-13 receptor subunit alpha-1 Interleukin-13 receptor subunit alpha-2 Interleukin-13 Interleukin-17A Interleukin-17F Interleukin-18 Interleukin-23 receptor Interleukin-23 subunit alpha Interleukin-4 receptor subunit alpha Interleukin-4 Interleukin-6 receptor subunit alpha Interleukin-6 Interleukin-8 Interstitial collagenase Laminin subunit alpha-5 Leukemia inhibitory factor Lipopolysaccharide-binding protein Low affinity immunoglobulin epsilon Fc receptor Matrix metalloproteinase-9 Metalloproteinase inhibitor 1 Mu-type opioid receptor Mucin-1 Myc proto-oncogene protein Necdin Neutrophil gelatinase-associated lipocalin Nitric oxide synthase, inducible Non-receptor tyrosine-protein kinase TYK2 Nuclear receptor ROR-alpha Nuclear receptor ROR-gamma Oncostatin-M POU domain, class 2, transcription factor 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Platelet glycoprotein 4 Polyunsaturated fatty acid 5-lipoxygenase Polyunsaturated fatty acid lipoxygenase ALOX15 Pro-opiomelanocortin Prostaglandin G/H synthase 2 Protein c-Fos RAC-alpha serine/threonine-protein kinase Rho-related GTP-binding protein RhoU Serine/threonine-protein kinase pim-1 Serum amyloid A-1 protein Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 6 Sphingosine 1-phosphate receptor 1 Stromelysin-1 Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Suppressor of cytokine signaling 5 Trans-acting T-cell-specific transcription factor GATA-3 Transcription factor JunB Transcription factor SOX-2 Transforming growth factor beta-1 proprotein Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor receptor superfamily member 1B Tumor necrosis factor Twist-related protein 1 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3 Vascular cell adhesion protein 1 Vascular endothelial growth factor A, long form Vimentin Zinc finger E-box-binding homeobox 1	O00626 O14543 O15230 O15392 O15524 O43524 O60674 O75159 P00488 P01033 P01100 P01106 P01137 P01189 P01375 P01583 P01584 P01854 P01857 P01861 P02751 P03956 P04083 P04637 P05107 P05112 P05231 P05362 P05556 P06734 P07900 P08123 P08253 P08254 P08670 P08887 P09038 P09601 P09917 P0DJI8 P10145 P10415 P11142 P11215 P11309 P13500 P13725 P14210 P14625 P14780 P14859 P15018 P15692 P15941 P16050 P16671 P17275 P18428 P19320 P20333 P20702 P21397 P21453 P22301 P23458 P23771 P24385 P24394 P27986 P29459 P29460 P29597 P31749 P31785 P35225 P35228 P35354 P35372 P35398 P37275 P38936 P40763 P41143 P41182 P42224 P42226 P48023 P48431 P49716 P51449 P51671 P52333 P78552 P80188 Q07817 Q07820 Q12778 Q14116 Q14627 Q15306 Q15672 Q16520 Q16552 Q16658 Q16665 Q5VWK5 Q7L0Q8 Q96PD4 Q99608 Q9H9S0 Q9NPF7	AKT1 ALOX15 ALOX5 ANX1 ANXA1 API4 APRF APT1LG1 AREB6 ARHU BATF BCL1 BCL2 BCL2L BCL2L1 BCL2L3 BCL5 BCL6 BCLX BHLHA38 BHLHE39 BHLHE78 BIRC5 CAP20 CCL11 CCL2 CCL22 CCND1 CD11B CD11C CD18 CD23A CD36 CD95L CDC42L1 CDKN1 CDKN1A CEBPD CHEDG1 CIP1 CIS3 CIS6 CISH5 CISH6 CLEC4J CLG CLG4A CLG4B CLGI COL1A2 COX2 CR3A CTLA8 CXCL8 EDG1 F13A F13A1 FAN1 FASL FASLG FCE2 FCER2 FGF2 FGFB FKHR FKHRL1 FN FN1 FNRB FOS FOXO1 FOXO1A FOXO3 FOXO3A FSCN1 G0S7 G28K GATA3 GP3B GP4 GRB1 GRP94 HGF HIF1A HILDA HMOX1 HNL HO HO1 HPTA HSC70 HSN HSP73 HSP90A HSP90AA1 HSP90B1 HSPA10 HSPA8 HSPC1 HSPC4 HSPCA IAP4 ICAM1 IFNB2 IGEBF IGHE IGHG1 IGHG4 IGIF IL10 IL12A IL12B IL13 IL13R IL13RA IL13RA1 IL13RA2 IL17 IL17A IL17F IL18 IL1A IL1B IL1F1 IL1F2 IL1F4 IL23A IL23R IL2RG IL4 IL4R IL4RA IL6 IL6R IL8 IRF4 ITGAM ITGAX ITGB1 ITGB2 JAK1 JAK1A JAK1B JAK2 JAK3 JUNB KIAA0533 KIAA0671 KIAA1907 LAMA5 LAZ3 LBP LCN2 LIF LOG15 LOG5 LPC1 MAOA MCL1 MCP1 MDA6 MDC MDF2 MFI7 MMP1 MMP2 MMP3 MMP9 MOP1 MOR1 MSK12 MUC1 MUM1 MYC NANOG NC30 NDN NGAL NKSF1 NKSF2 NOS2 NOS2A NR1F1 NR1F3 OCT1 OPRD OPRD1 OPRM1 OSM OTF1 P53 PASD8 PIC1 PIK3R1 PIM1 PKB POMC POU2F1 PRAD1 PTGS2 PUM RAC RHOU RORA RORC RORG RZRA RZRG S1PR1 SAA1 SCYA11 SCYA2 SCYA22 SDI1 SGRF SNL SOCS1 SOCS3 SOCS5 SOX2 SSI1 SSI3 STAT1 STAT3 STAT6 STMY1 TCF8 TGFB TGFB1 TIMP TIMP1 TIP3 TNF TNFA TNFBR TNFR2 TNFRSF1B TNFSF2 TNFSF6 TP53 TRA1 TWIST TWIST1 TYK2 VCAM1 VEGF VEGFA VIM WAF1 WRCH1 ZBTB27 ZEB1 ZNF51
Translocation of SLC2A4 (GLUT4) to the plasma membrane	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-1 5'-AMP-activated protein kinase subunit gamma-2 5'-AMP-activated protein kinase subunit gamma-3 C2 domain-containing protein 5 Calmodulin-1 Exocyst complex component 1 Exocyst complex component 2 Exocyst complex component 3 Exocyst complex component 4 Exocyst complex component 5 Exocyst complex component 6 Exocyst complex component 7 Exocyst complex component 8 Kinesin-associated protein 3 Kinesin-like protein KIF3A Kinesin-like protein KIF3B Leucyl-cystinyl aminopeptidase Myosin-9 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase Ral GTPase-activating protein subunit alpha-2 Ral GTPase-activating protein subunit beta Ras-related C3 botulinum toxin substrate 1 Ras-related protein Rab-10 Ras-related protein Rab-11A Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-4A Ras-related protein Rab-8A Ras-related protein Ral-A Rho-related GTP-binding protein RhoQ Solute carrier family 2, facilitated glucose transporter member 4 Synaptosomal-associated protein 23 Syntaxin-4 Syntaxin-binding protein 3 TBC1 domain family member 1 TBC1 domain family member 4 Tether containing UBX domain for GLUT4 Unconventional myosin-Ic Unconventional myosin-Va Vesicle-associated membrane protein 2	O00159 O00161 O00186 O00471 O15066 O43741 O60343 O60645 P0DP23 P11233 P14672 P17081 P20338 P27348 P31749 P31751 P31946 P31947 P35579 P51153 P54619 P54646 P61006 P61026 P61106 P61981 P62258 P62491 P63000 P63027 P63104 Q04917 Q12846 Q2PPJ7 Q86TI0 Q86X10 Q86YS7 Q8IYI6 Q8TAG9 Q92845 Q96A65 Q96KP1 Q9BZE9 Q9NV70 Q9UGI9 Q9UGJ0 Q9UIQ6 Q9UPT5 Q9Y478 Q9Y496 Q9Y4I1	AKT1 AKT2 AMPK AMPK2 AMPKG3 ARHQ AS160 ASPL ASPSCR1 C20orf74 C2CD5 CALM CALM1 CAM CAM1 CDP138 EXO70 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 GLUT4 HME1 KIAA0359 KIAA0528 KIAA0603 KIAA1067 KIAA1108 KIAA1219 KIAA1272 KIAA1699 KIF3 KIF3A KIF3AP KIF3B KIFAP3 LNPEP MEL MYH12 MYH9 MYO1C MYO5A OTASE PKB PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RAB10 RAB11 RAB11A RAB13 RAB14 RAB4 RAB4A RAB8 RAB8A RAC RAC1 RAL RALA RALGAPA2 RALGAPB RASL7A RCC17 RHOQ SEC10 SEC10L1 SEC15A SEC15L SEC15L1 SEC3 SEC3L1 SEC5 SEC5L1 SEC6 SEC6L1 SEC8 SEC8L1 SFN SLC2A4 SMAP SNAP23 STX4 STX4A STXBP3 SYB2 TBC1D1 TBC1D4 TC10 TC25 TUG UBXD9 UBXN9 VAMP2 YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Deactivation of the beta-catenin transactivating complex	14-3-3 protein zeta/delta Adenomatous polyposis coli protein B-cell CLL/lymphoma 9 protein B-cell CLL/lymphoma 9-like protein Beta-catenin-interacting protein 1 C-terminal-binding protein 1 Catenin beta-1 Chromodomain-helicase-DNA-binding protein 8 E3 ubiquitin-protein ligase XIAP Exportin-1 F-box/WD repeat-containing protein 1A Histone deacetylase 1 Histone-lysine N-methyltransferase 2D Lymphoid enhancer-binding factor 1 Menin Polyubiquitin-B Polyubiquitin-C Protein chibby homolog 1 Pygopus homolog 1 Pygopus homolog 2 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase Retinoblastoma-binding protein 5 Set1/Ash2 histone methyltransferase complex subunit ASH2 Sex-determining region Y protein Transcription factor 7-like 1 Transcription factor 7-like 2 Transcription factor 7 Transcription factor SOX-13 Transcription factor SOX-17 Transcription factor SOX-2 Transcription factor SOX-3 Transcription factor SOX-4 Transcription factor SOX-6 Transcription factor SOX-7 Transcription factor SOX-9 Transducin-like enhancer protein 1 Transducin-like enhancer protein 2 Transducin-like enhancer protein 3 Transducin-like enhancer protein 4 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00255 O00512 O14686 O14980 P0CG47 P0CG48 P25054 P31749 P31751 P35222 P35712 P36402 P41225 P48431 P48436 P62979 P62987 P63104 P98170 Q04724 Q04725 Q04726 Q04727 Q05066 Q06945 Q13363 Q13547 Q15291 Q86UU0 Q9BRQ0 Q9BT81 Q9H6I2 Q9HCK8 Q9HCS4 Q9NQB0 Q9NSA3 Q9UBL3 Q9UJU2 Q9UN79 Q9Y297 Q9Y3M2 Q9Y3Y4	AKT1 AKT2 ALR APC API3 ARB1 ASH2L ASH2L1 BCL9 BCL9L BIRC4 BTRC BTRCP C22orf2 CBY CBY1 CHD8 CRM1 CTBP CTBP1 CTNNB CTNNB1 CTNNBIP1 DLNB11 DP2.5 FBW1A FBXW1A GRG4 HDAC1 HELSNF1 IAP3 ICAT KIAA1261 KIAA1547 KIAA1564 KMT2D LEF1 MEN1 MLL2 MLL4 PGEA1 PKB PYGO1 PYGO2 RAC RBBP5 RBQ3 RPD3L1 RPS27A SCG2 SOX13 SOX17 SOX2 SOX3 SOX4 SOX6 SOX7 SOX9 SRY TCF1 TCF3 TCF4 TCF7 TCF7L1 TCF7L2 TDF TLE1 TLE2 TLE3 TLE4 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 XIAP XPO1 YWHAZ
AKT-mediated inactivation of FOXO1A	Forkhead box protein O1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase	P31749 P31751 Q12778 Q9Y243	AKT1 AKT2 AKT3 FKHR FOXO1 FOXO1A PKB PKBG RAC
Downregulation of ERBB2:ERBB3 signaling	E3 ubiquitin-protein ligase NRDP1 Polyubiquitin-B Polyubiquitin-C Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor tyrosine-protein kinase erbB-2 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14511 P04626 P0CG47 P0CG48 P31749 P31751 P40818 P62979 P62987 Q02297 Q9H4P4 Q9Y243	AKT1 AKT2 AKT3 ERBB2 FLRF GGF HER2 HGL HRGA KIAA0055 MLN19 NDF NEU NGL NRDP1 NRG1 NRG2 NTAK PKB PKBG RAC RNF41 RPS27A SMDF UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBPY USP8
CTLA4 inhibitory signaling	Cytotoxic T-lymphocyte protein 4 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes Tyrosine-protein phosphatase non-receptor type 11	P06239 P06241 P07947 P07948 P16410 P30153 P30154 P31749 P31751 P33681 P42081 P62714 P67775 Q06124 Q13362 Q14738 Q15172 Q15173 Q16537 Q9Y243	AKT1 AKT2 AKT3 CD152 CD28LG CD28LG1 CD28LG2 CD80 CD86 CTLA4 FYN JTK8 KIAA0044 LAB7 LCK LYN PKB PKBG PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PTP2C PTPN11 RAC SHPTP2 YES YES1
RUNX2 regulates genes involved in cell migration	Collagenase 3 Core-binding factor subunit beta Integrin alpha-5 Integrin beta-like protein 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase	O95965 P08648 P31749 P31751 P45452 Q13951 Q9Y243	AKT1 AKT2 AKT3 CBFB FNRA ITGA5 ITGBL1 MMP13 OSCP PKB PKBG RAC TIED
Negative regulation of the PI3K/AKT network	Acyl-coenzyme A thioesterase THEM4 PH domain leucine-rich repeat-containing protein phosphatase 1 PH domain leucine-rich repeat-containing protein phosphatase 2 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Tribbles homolog 3	O60346 P31749 P31751 P60484 Q5T1C6 Q6ZVD8 Q96RU7 Q9Y243	AKT1 AKT2 AKT3 C20orf97 CTMP KIAA0606 KIAA0931 MMAC1 NIPK PHLPP PHLPP1 PHLPP2 PHLPPL PKB PKBG PLEKHE1 PTEN RAC SCOP SKIP3 TEP1 THEM4 TRB3 TRIB3
CD28 dependent PI3K/Akt signaling	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Membrane protein Mitogen-activated protein kinase kinase kinase 14 Mitogen-activated protein kinase kinase kinase 8 Nucleoprotein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proline-rich protein 5 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Serine/threonine-protein kinase mTOR T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck	O00459 O15530 P06239 P06241 P0DTC5 P0DTC9 P10747 P27986 P31749 P31751 P33681 P41279 P42081 P42336 P42345 P85299 Q5T1C6 Q6R327 Q92569 Q96RU7 Q99558 Q9BPZ7 Q9BVC4 Q9Y243	AKT1 AKT2 AKT3 C20orf97 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 COT CTMP ESTF FRAP FRAP1 FRAP2 FYN GBL GRB1 KIAA1999 LAB7 LCK LST8 M MAP3K14 MAP3K8 MAPKAP1 MIP1 MLST8 MTOR N NIK NIPK PDK1 PDPK1 PIK3CA PIK3R1 PIK3R2 PIK3R3 PKB PKBG PROTOR1 PRR5 RAC RAFT1 RAPT1 RICTOR SIN1 SKIP3 THEM4 TRB3 TRIB3
VEGFR2 mediated vascular permeability	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Cadherin-5 Calmodulin-1 Catenin alpha-1 Catenin beta-1 Catenin delta-1 Caveolin-1 Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Heat shock protein HSP 90-alpha Junction plakoglobin Membrane protein Nitric oxide synthase 3 Nucleoprotein Proline-rich protein 5 Proto-oncogene vav RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Ras-related C3 botulinum toxin substrate 1 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase mTOR Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3	O15530 O60716 O75914 P07900 P0DP23 P0DTC5 P0DTC9 P14923 P15498 P29474 P31749 P31751 P33151 P35221 P35222 P42345 P52735 P63000 P85299 Q03135 Q13153 Q13177 Q5T1C6 Q6R327 Q96RU7 Q9BPZ7 Q9BVC4 Q9UKW4 Q9Y243	AKT1 AKT2 AKT3 C20orf97 CALM CALM1 CAM CAM1 CAV CAV1 CDH5 CTMP CTNNA1 CTNNB CTNNB1 CTNND1 CTNNG DP3 FRAP FRAP1 FRAP2 GBL HSP90A HSP90AA1 HSPC1 HSPCA JUP KIAA0384 KIAA1999 LST8 M MAPKAP1 MIP1 MLST8 MTOR N NIPK NOS3 OPHN3 PAK1 PAK2 PAK3 PDK1 PDPK1 PKB PKBG PROTOR1 PRR5 RAC RAC1 RAFT1 RAPT1 RICTOR SIN1 SKIP3 TC25 THEM4 TRB3 TRIB3 VAV VAV1 VAV2 VAV3
Regulation of TP53 Activity through Acetylation	Bromodomain and PHD finger-containing protein 3 Bromodomain-containing protein 1 Bromodomain-containing protein 7 Cellular tumor antigen p53 Chromatin modification-related protein MEAF6 Chromodomain-helicase-DNA-binding protein 3 Chromodomain-helicase-DNA-binding protein 4 Histone acetyltransferase KAT6A Histone acetyltransferase p300 Histone deacetylase 1 Histone deacetylase 2 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Inhibitor of growth protein 5 Metastasis-associated protein MTA2 Methyl-CpG-binding domain protein 3 Peregrin Protein PML RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Transcriptional repressor p66-alpha Transcriptional repressor p66-beta	O94776 O95696 O95983 P04637 P29590 P31749 P31751 P55201 Q09028 Q09472 Q12873 Q13547 Q14839 Q16576 Q86YP4 Q8WXI9 Q8WYH8 Q92769 Q92794 Q9HAF1 Q9NPI1 Q9ULD4 Q9Y243	AKT1 AKT2 AKT3 BP75 BR140 BRD1 BRD7 BRL BRPF1 BRPF2 BRPF3 C1orf149 CELTIX1 CENP-28 CHD3 CHD4 EAF6 EP300 GATAD2A GATAD2B HDAC1 HDAC2 ING5 KAT6A KIAA1150 KIAA1286 MBD3 MEAF6 MOZ MTA1L1 MTA2 MYL MYST3 P300 P53 PID PKB PKBG PML PP8675 RAC RBAP46 RBAP48 RBBP4 RBBP7 RNF71 RPD3L1 RUNXBP2 TP53 TRIM19 ZNF220
FLT3 Signaling	Bcl-2-like protein 11 Cyclin-dependent kinase inhibitor 1B Fms-related tyrosine kinase 3 ligand Forkhead box protein O3 GRB2-associated-binding protein 2 GRB2-related adapter protein 2 GTPase HRas GTPase NRas Growth factor receptor-bound protein 10 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Receptor-type tyrosine-protein kinase FLT3 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11	O43521 O43524 O75791 P01111 P01112 P27986 P31749 P31751 P36888 P42336 P46527 P49771 Q06124 Q07889 Q13322 Q9UQC2 Q9Y243	AKT1 AKT2 AKT3 BCL2L11 BIM CD135 CDKN1B FKHRL1 FLK2 FLT3 FLT3LG FOXO3 FOXO3A GAB2 GADS GRAP2 GRB1 GRB10 GRB2L GRBIR GRID HRAS HRAS1 KIAA0207 KIAA0571 KIP1 NRAS PIK3CA PIK3R1 PKB PKBG PTP2C PTPN11 RAC SHPTP2 SOS1 STK1 p27
Cyclin E associated events during G1/S transition	CDK-activating kinase assembly factor MAT1 CDK5 and ABL1 enzyme substrate 1 Cyclin-H Cyclin-dependent kinase 2 Cyclin-dependent kinase 7 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B G1/S-specific cyclin-E1 G1/S-specific cyclin-E2 Histone-binding protein RBBP4 M-phase inducer phosphatase 1 Myc proto-oncogene protein Protein lin-37 homolog Protein lin-52 homolog Protein lin-54 homolog Protein lin-9 homolog Protein max RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Retinoblastoma-associated protein Retinoblastoma-like protein 2 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F4 Transcription factor E2F5 Wee1-like protein kinase	O96020 P01106 P06400 P24864 P24941 P30291 P30304 P31749 P31751 P38936 P46527 P50613 P51946 P51948 P61244 Q01094 Q08999 Q09028 Q14186 Q14188 Q15329 Q16254 Q52LA3 Q5TKA1 Q6MZP7 Q8TDN4 Q96GY3 Q9Y243	AKT1 AKT2 AKT3 BARA BHLHD4 BHLHE39 C14orf46 CABLES CABLES1 CAK CAK1 CAP20 CAP35 CCNE CCNE1 CCNE2 CCNH CDC25A CDK2 CDK7 CDKN1 CDKN1A CDKN1B CDKN2 CDKN7 CIP1 CXCDC1 DP1 DP2 E2F1 E2F4 E2F5 KIAA2037 KIP1 LIN37 LIN52 LIN54 LIN9 MAT1 MAX MDA6 MNAT1 MO15 MYC PIC1 PKB PKBG RAC RB1 RB2 RBAP48 RBBP3 RBBP4 RBL2 RNF66 SDI1 STK1 TFDP1 TFDP2 TGS WAF1 WEE1 p27
Cyclin A:Cdk2-associated events at S phase entry	CDK-activating kinase assembly factor MAT1 CDK5 and ABL1 enzyme substrate 1 Cyclin-A1 Cyclin-A2 Cyclin-H Cyclin-dependent kinase 2 Cyclin-dependent kinase 7 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Fizzy-related protein homolog Histone-binding protein RBBP4 M-phase inducer phosphatase 1 M-phase inducer phosphatase 2 Myc proto-oncogene protein Protein lin-37 homolog Protein lin-52 homolog Protein lin-54 homolog Protein lin-9 homolog Protein max RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Retinoblastoma-associated protein Retinoblastoma-like protein 2 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F4 Transcription factor E2F5 Wee1-like protein kinase	P01106 P06400 P20248 P24941 P30291 P30304 P30305 P31749 P31751 P38936 P46527 P50613 P51946 P51948 P61244 P78396 Q01094 Q08999 Q09028 Q14186 Q14188 Q15329 Q16254 Q52LA3 Q5TKA1 Q6MZP7 Q8TDN4 Q96GY3 Q9UM11 Q9Y243	AKT1 AKT2 AKT3 BARA BHLHD4 BHLHE39 C14orf46 CABLES CABLES1 CAK CAK1 CAP20 CAP35 CCN1 CCNA CCNA1 CCNA2 CCNH CDC25A CDC25B CDC25HU2 CDH1 CDK2 CDK7 CDKN1 CDKN1A CDKN1B CDKN2 CDKN7 CIP1 CXCDC1 DP1 DP2 E2F1 E2F4 E2F5 FYR FZR FZR1 KIAA1242 KIAA2037 KIP1 LIN37 LIN52 LIN54 LIN9 MAT1 MAX MDA6 MNAT1 MO15 MYC PIC1 PKB PKBG RAC RB1 RB2 RBAP48 RBBP3 RBBP4 RBL2 RNF66 SDI1 STK1 TFDP1 TFDP2 TGS WAF1 WEE1 p27
Activation of BAD and translocation to mitochondria	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta Apoptosis regulator Bcl-2 BH3-interacting domain death agonist Bcl2-associated agonist of cell death Calcineurin subunit B type 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	P10415 P27348 P31749 P31751 P31946 P31947 P48454 P55957 P61981 P62258 P63098 P63104 Q04917 Q92934 Q9Y243	AKT1 AKT2 AKT3 BAD BBC6 BCL2 BCL2L8 BID CALNA3 CNA2 CNA3 CNB HME1 PKB PKBG PPP3CC PPP3R1 RAC SFN YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Regulation of TP53 Degradation	3-phosphoinositide-dependent protein kinase 1 Cellular tumor antigen p53 Cyclin-A1 Cyclin-A2 Cyclin-G1 Cyclin-dependent kinase 1 Cyclin-dependent kinase 2 Death domain-associated protein 6 E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase RNF34 E3 ubiquitin-protein ligase rififylin PHD finger protein 20 Polyubiquitin-B Polyubiquitin-C Proline-rich protein 5 Protein Mdm4 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Serine-protein kinase ATM Serine/threonine-protein kinase Chk2 Serine/threonine-protein kinase Sgk1 Serine/threonine-protein kinase mTOR Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tumor suppressor ARF Ubiquitin carboxyl-terminal hydrolase 2 Ubiquitin carboxyl-terminal hydrolase 7 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00141 O15151 O15530 O75604 O96017 P04637 P06493 P0CG47 P0CG48 P20248 P24941 P30153 P30154 P31749 P31751 P42345 P51959 P62714 P62979 P62987 P67775 P78396 P85299 Q00987 Q13315 Q13362 Q6R327 Q8N726 Q8WZ73 Q93009 Q969K3 Q9BPZ7 Q9BVC4 Q9BVI0 Q9UER7 Q9Y243	AKT1 AKT2 AKT3 ATM BING2 C20orf104 CCN1 CCNA CCNA1 CCNA2 CCNG CCNG1 CDC2 CDC28A CDK1 CDK2 CDKN1 CDKN2 CDKN2A CDS1 CHEK2 CHK2 CYCG1 DAP6 DAXX FRAP FRAP1 FRAP2 GBL GLEA2 HAUSP HCA58 KIAA0044 KIAA1999 LST8 MAPKAP1 MDM2 MDM4 MDMX MIP1 MLM MLST8 MTOR NZF P34CDC2 P53 PDK1 PDPK1 PHF20 PKB PKBG PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5C PROTOR1 PRR5 RAC RAD53 RAFT1 RAPT1 RFFL RICTOR RNF189 RNF34 RNF34L RPS27A SGK SGK1 SIN1 TP53 TZP UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBP41 USP2 USP7
Regulation of TP53 Activity through Association with Co-factors	Apoptosis-stimulating of p53 protein 1 Apoptosis-stimulating of p53 protein 2 Cellular tumor antigen p53 PHD finger protein 20 POU domain, class 4, transcription factor 1 POU domain, class 4, transcription factor 2 Protein BANP RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase RelA-associated inhibitor Tumor protein 63 Tumor protein p73 Zinc finger protein 385A	O15350 P04637 P31749 P31751 Q01851 Q12837 Q13625 Q8N9N5 Q8WUF5 Q96KQ4 Q96PM9 Q9BVI0 Q9H3D4 Q9Y243	AKT1 AKT2 AKT3 ASPP1 ASPP2 BANP BBP BEND1 BRN3A BRN3B C20orf104 GLEA2 HCA58 HZF IASPP KET KIAA0771 NKIP1 NZF P53 P63 P73 P73H P73L PHF20 PKB PKBG POU4F1 POU4F2 PPP1R13B PPP1R13BL PPP1R13L RAC RAI RDC1 RZF SMAR1 TP53 TP53BP2 TP63 TP73 TP73L TZP ZNF385 ZNF385A
G beta:gamma signalling through PI3Kgamma	3-phosphoinositide-dependent protein kinase 1 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Phosphoinositide 3-kinase regulatory subunit 5 Phosphoinositide 3-kinase regulatory subunit 6 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Transforming protein RhoA	O14610 O14775 O15530 O60262 P16520 P31749 P31751 P48736 P50150 P50151 P59768 P61586 P61952 P62873 P62879 P63211 P63215 P63218 Q5UE93 Q8WYR1 Q9HAV0 Q9P2W3 Q9UBI6 Q9UK08 Q9Y243	AKT1 AKT2 AKT3 ARH12 ARHA C17orf38 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 PDK1 PDPK1 PIK3CG PIK3R5 PIK3R6 PKB PKBG RAC RHO12 RHOA
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Amphiregulin Apoptosis regulator Bcl-2 Cyclin-dependent kinase inhibitor 1B ETS domain-containing protein Elk-1 Epidermal growth factor receptor Epigen Exportin-1 Focal adhesion kinase 1 Forkhead box protein O3 G1/S-specific cyclin-D1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein c-Fos Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Serine/threonine-protein kinase Kist Serum response factor	O14944 O14980 O43524 P00533 P01100 P01133 P01135 P10415 P11831 P15514 P19419 P24385 P27361 P28482 P31749 P31751 P35070 P46527 Q05397 Q6UW88 Q8TAS1 Q99075 Q9Y243	AKT1 AKT2 AKT3 AREG AREGB BCL1 BCL2 BTC CCND1 CDKN1B CRM1 DTR DTS EGF EGFR ELK1 EPGN ERBB ERBB1 EREG ERK1 ERK2 FAK FAK1 FKHRL1 FOS FOXO3 FOXO3A G0S7 HBEGF HEGFL HER1 KIP1 KIS KIST MAPK1 MAPK3 PKB PKBG PRAD1 PRKM1 PRKM2 PRKM3 PTK2 RAC SDGF SRF TGFA UHMK1 XPO1 p27
PI3K/AKT Signaling	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Amphiregulin B-lymphocyte antigen CD19 Beta-klotho Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-like 1 Interleukin-33 Mast/stem cell growth factor receptor Kit Membrane protein Myeloid differentiation primary response protein MyD88 Nucleoprotein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphoinositide 3-kinase adapter protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proline-rich protein 5 Proto-oncogene tyrosine-protein kinase Src Proto-oncogene vav Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Rho-related GTP-binding protein RhoG Serine/threonine-protein kinase Sgk1 Serine/threonine-protein kinase mTOR Striatin T-cell receptor-associated transmembrane adapter 1 T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 TNF receptor-associated factor 6 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein phosphatase non-receptor type 11	O00141 O00329 O00459 O14511 O14944 O15520 O15530 O43320 O43815 O76093 O95750 O95760 P00533 P01127 P01133 P01135 P03372 P04626 P05230 P06239 P06241 P08581 P08620 P09038 P09619 P0DTC5 P0DTC9 P10721 P10747 P10767 P11487 P12931 P14210 P15153 P15391 P15498 P15514 P16234 P21781 P22455 P27986 P31371 P31749 P31751 P33681 P35070 P35568 P36888 P42081 P42336 P42338 P42345 P49771 P51617 P56975 P63000 P84095 P85299 Q01638 Q02297 Q06124 Q13480 Q5T1C6 Q6PIZ9 Q6R327 Q6UW88 Q6ZUJ8 Q86Z14 Q8WU20 Q8WWG1 Q92569 Q92731 Q96RU7 Q99075 Q99836 Q9BPZ7 Q9BVC4 Q9GZV9 Q9HCT0 Q9NP95 Q9NWZ3 Q9UQC2 Q9Y243 Q9Y4H2 Q9Y4K3	AKT1 AKT2 AKT3 AREG AREGB ARHG BCAP BTC C20orf97 C9orf26 CD135 CD19 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 CTMP DER4 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ESR ESR1 ESR2 ESTRB FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRAP FRAP1 FRAP2 FRS2 FYN GAB1 GAB2 GBL GGF GRB1 HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRGA HST HST2 HSTF1 HSTF2 HYPF IL1F11 IL1RL1 IL33 INT2 IRAK IRAK1 IRAK4 IRS1 IRS2 JTK2 KGF KIAA0571 KIAA1999 KIT KLB KS3 LAB7 LCK LST8 M MAPKAP1 MET MIP1 MLN19 MLST8 MTOR MYD88 N NDF NEU NFHEV NGL NIPK NR3A1 NR3A2 NRG1 NRG2 NRG3 NRG4 NTAK PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PDK1 PDPK1 PIK3AP1 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PKB PKBG PROTOR1 PRR5 PTP2C PTPN11 RAC RAC1 RAC2 RAFT1 RAPT1 RHEPDGFRA RHOG RICTOR RNF85 SCFR SDGF SGK SGK1 SHPTP2 SIN1 SIS SKIP3 SMDF SRC SRC1 ST2 STK1 STRN T1 TC25 TCRIM TGFA THEM4 TKF TRAF6 TRAT1 TRB3 TRIB3 VAV VAV1
Regulation of PTEN stability and activity	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Casein kinase II subunit alpha' Casein kinase II subunit alpha Casein kinase II subunit beta E3 ubiquitin-protein ligase CHIP E3 ubiquitin-protein ligase NEDD4 E3 ubiquitin-protein ligase RNF146 E3 ubiquitin-protein ligase XIAP E3 ubiquitin-protein ligase makorin-1 NEDD4-like E3 ubiquitin-protein ligase WWP2 OTU domain-containing protein 3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein Poly [ADP-ribose] polymerase tankyrase-1 Poly [ADP-ribose] polymerase tankyrase-2 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Tyrosine-protein kinase FRK Ubiquitin carboxyl-terminal hydrolase 13 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Zinc finger protein RFP	A5LHX3 O00231 O00232 O00233 O00308 O00487 O14818 O43242 O75832 O95271 P0CG47 P0CG48 P14373 P17980 P19784 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P31749 P31751 P35998 P40306 P42685 P43686 P46934 P48556 P49720 P49721 P51665 P55036 P60484 P60896 P60900 P61289 P62191 P62195 P62333 P62979 P62987 P67870 P68400 P98170 Q06323 Q13200 Q14997 Q15008 Q16401 Q5T2D3 Q70Z35 Q8TAA3 Q92530 Q92995 Q99436 Q99460 Q9H2K2 Q9NTX7 Q9UHC7 Q9UL46 Q9UNE7 Q9UNM6 Q9Y243	AKT1 AKT2 AKT3 API3 BIRC4 C7orf76 CHIP CK2A1 CK2A2 CK2N CSNK2A1 CSNK2A2 CSNK2B DEPDC2 DSS1 FRK G5A HC2 HC3 HC8 HC9 HSPC IAP3 IFI5111 ISOT3 KIAA0072 KIAA0077 KIAA0093 KIAA0107 KIAA0459 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MKRN1 MMAC1 MOV34L MSS1 NEDD4 NEDD4-1 NU OTUD3 PARP5A PARP5B PARPL PFAAP4 PKB PKBG POH1 PREX2 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTEN PTK5 RAC RAK RFP RING10 RING12 RNF146 RNF61 RNF76 RPF1 RPS27A SEM1 SHFDG1 SHFM1 STUB1 SUG1 SUG2 TANK2 TBP1 TBP7 TEP1 TIN1 TINF1 TNKL TNKS TNKS1 TNKS2 TRAP2 TRIM27 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 USP13 WWP2 X XIAP Y Y2 Z
KEAP1-NFE2L2 pathway	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 APC membrane recruitment protein 1 Breast cancer type 1 susceptibility protein Casein kinase II subunit alpha' Casein kinase II subunit alpha Casein kinase II subunit beta Cullin-3 Cyclin-dependent kinase inhibitor 1 Dipeptidyl peptidase 3 E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase TRIM21 Eukaryotic translation initiation factor 2-alpha kinase 3 Kelch-like ECH-associated protein 1 Microtubule-associated proteins 1A/1B light chain 3B Mitochondrial ubiquitin ligase activator of NFKB 1 Nuclear factor erythroid 2-related factor 2 Nuclear protein localization protein 4 homolog Partner and localizer of BRCA2 Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Protein X Protein kinase C delta type Protein kinase C iota type RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Sequestosome-1 Sestrin-1 Sestrin-2 Transitional endoplasmic reticulum ATPase UBX domain-containing protein 7 Ubiquitin recognition factor in ER-associated degradation protein 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5LHX3 O00231 O00232 O00233 O00487 O14818 O43242 O75832 O94888 P0CG47 P0CG48 P17980 P19474 P19784 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P31749 P31751 P35998 P38398 P38936 P40306 P41743 P43686 P48556 P49720 P49721 P51665 P55036 P55072 P58004 P60896 P60900 P61289 P62191 P62195 P62333 P62877 P62979 P62987 P67870 P68400 Q05655 Q06323 Q13200 Q13501 Q13618 Q14145 Q14997 Q15008 Q16236 Q16401 Q2F514 Q5JTC6 Q86YC2 Q8TAA3 Q8TAT6 Q92530 Q92890 Q969V5 Q99436 Q99460 Q9GZQ8 Q9NY33 Q9NZJ5 Q9UL46 Q9UNM6 Q9Y243 Q9Y6P5	AKT1 AKT2 AKT3 AMER1 BRCA1 C1orf166 C7orf76 CAP20 CDKN1 CDKN1A CIP1 CK2A1 CK2A2 CK2N CSNK2A1 CSNK2A2 CSNK2B CUL3 DPP3 DSS1 DXS1179E EIF2AK3 FAM123B FANCN G5A GIDE HC2 HC3 HC8 HC9 HEL-220 HEL-S-70 HSPC Hi95 IFI5111 INRF2 KEAP1 KIAA0072 KIAA0077 KIAA0107 KIAA0132 KIAA0617 KIAA0794 KIAA1499 KLHL19 LMP10 LMP2 LMP7 LMPX LMPY MAP1ALC3 MAP1LC3B MAPL MB1 MCB1 MDA6 MECL1 MIP224 MOV34L MSS1 MUL1 MULAN NFE2L2 NPL4 NPLOC4 NRF2 NU ORCA OSIL PA26 PALB2 PEK PERK PFAAP4 PIC1 PKB PKBG PKCD POH1 PRKCD PRKCI PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RAC RBX1 RING10 RING12 RNF218 RNF53 RNF75 RNF81 RO52 ROC1 RPS27A SDI1 SEM1 SESN1 SESN2 SEST1 SEST2 SHFDG1 SHFM1 SQSTM1 SSA1 SUG1 SUG2 TBP1 TBP7 TRAP2 TRIM21 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBXD7 UBXN7 UFD1 UFD1L VCP WAF1 WTX X Y Y2 Z x

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