GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **1676 - 1700** of **2074** in total

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Pathway Name	Protein Name	UniProt ID ▼	Gene Symbol	Organism
P2Y receptors	Lysophosphatidic acid receptor 4 Lysophosphatidic acid receptor 6 P2Y purinoceptor 11 P2Y purinoceptor 12 P2Y purinoceptor 13 P2Y purinoceptor 14 P2Y purinoceptor 1 P2Y purinoceptor 2 P2Y purinoceptor 4 P2Y purinoceptor 6 Putative P2Y purinoceptor 10 Uracil nucleotide/cysteinyl leukotriene receptor	O00398 P41231 P43657 P47900 P51582 Q13304 Q15077 Q15391 Q96G91 Q99677 Q9BPV8 Q9H244	GPR105 GPR17 GPR23 GPR86 GPR94 HORK3 KIAA0001 LPA4 LPAR4 LPAR6 NRU P2RU1 P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY5 P2RY6 P2RY9	Homo sapiens (human)
Transport of inorganic cations/anions and amino acids/oligopeptides	Cystinosin Excitatory amino acid transporter 1 Excitatory amino acid transporter 2 Excitatory amino acid transporter 3 Excitatory amino acid transporter 4 Excitatory amino acid transporter 5 Mitochondrial S-adenosylmethionine carrier protein Vesicular inhibitory amino acid transporter	O00341 O60931 P43003 P43004 P43005 P48664 Q70HW3 Q9H598	CTNS EAAC1 EAAT1 EAAT2 EAAT3 EAAT4 EAAT5 GLAST GLAST1 GLT1 HEAAC1 SAMC SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 SLC25A26 SLC32A1 VGAT VIAAT	Homo sapiens (human)
Glutamate Neurotransmitter Release Cycle	Complexin-1 Excitatory amino acid transporter 1 Excitatory amino acid transporter 2 Excitatory amino acid transporter 3 Excitatory amino acid transporter 4 Excitatory amino acid transporter 5 Glutaminase kidney isoform, mitochondrial Glutaminase liver isoform, mitochondrial Liprin-alpha-1 Liprin-alpha-2 Liprin-alpha-3 Liprin-alpha-4 PRA1 family protein 3 Peripheral-type benzodiazepine receptor-associated protein 1 Protein unc-13 homolog B Ras-related protein Rab-3A Regulating synaptic membrane exocytosis protein 1 Sodium-coupled neutral amino acid symporter 2 Synaptosomal-associated protein 25 Synaptotagmin-1 Syntaxin-1A Vesicle-associated membrane protein 2 Vesicular glutamate transporter 1	O00341 O14795 O14810 O75145 O75334 O75335 O75915 O94925 O95153 P20336 P21579 P43003 P43004 P43005 P48664 P60880 P63027 Q13136 Q16623 Q86UR5 Q96QD8 Q9P2U7 Q9UI32	ARL6IP5 ATA2 BNPI BZRAP1 CPLX1 DERP11 EAAC1 EAAT1 EAAT2 EAAT3 EAAT4 EAAT5 GA GLAST GLAST1 GLS GLS1 GLS2 GLT1 HEAAC1 JWA KIAA0340 KIAA0612 KIAA0654 KIAA0838 KIAA0897 KIAA1382 LIP1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PRA2 PRAF3 RAB3A RAB3IP2 RBP1 RIM1 RIMBP1 RIMS1 SAT2 SLC17A7 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 SLC38A2 SNAP SNAP25 SNAT2 STX1 STX1A SVP65 SYB2 SYT SYT1 TSPOAP1 UNC13 UNC13B VAMP2 VGLUT1	Homo sapiens (human)
Cytosolic sulfonation of small molecules	3'(2'),5'-bisphosphate nucleotidase 1 Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase Podocalyxin-like protein 2 Protein-tyrosine sulfotransferase 1 Protein-tyrosine sulfotransferase 2 Putative protein-lysine deacylase ABHD14B Sulfotransferase 1A1 Sulfotransferase 1A2 Sulfotransferase 1A3 Sulfotransferase 1A4 Sulfotransferase 1B1 Sulfotransferase 1C2 Sulfotransferase 1C4 Sulfotransferase 1E1 Sulfotransferase 2A1 Sulfotransferase 4A1 Sulfotransferase 6B1	O00338 O43704 O60507 O60704 O75897 O95861 P0DMM9 P0DMN0 P49888 P50225 P50226 Q06520 Q6IMI4 Q96IU4 Q9BR01 Q9NX62 Q9NZ53	ABHD14B BPNT1 BPNT2 CIB HST IMPA3 IMPAD1 PODXL2 ST1B2 STD STE STM STP STP1 STP2 SULT1A1 SULT1A2 SULT1A3 SULT1A4 SULT1B1 SULT1B2 SULT1C1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT4A1 SULT6B1 SULTX3 TPST1 TPST2	Homo sapiens (human)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	ADP-ribosylation factor-like protein 2-binding protein ADP-ribosylation factor-like protein 2 ADP/ATP translocase 1 ADP/ATP translocase 2 ADP/ATP translocase 3 Equilibrative nucleoside transporter 1 Equilibrative nucleoside transporter 2 Equilibrative nucleoside transporter 3 Equilibrative nucleoside transporter 4 Sodium/nucleoside cotransporter 1 Sodium/nucleoside cotransporter 2 Solute carrier family 28 member 3	O00337 O43868 P05141 P12235 P12236 P36404 Q14542 Q7RTT9 Q99808 Q9BZD2 Q9HAS3 Q9Y2Y0	AAC1 AAC2 AAC3 ANT1 ANT2 ANT3 ARL2 ARL2BP BART BART1 CNT1 CNT2 CNT3 DER12 ENT1 ENT2 ENT3 ENT4 HNP36 PMAT SLC25A4 SLC25A5 SLC25A6 SLC28A1 SLC28A2 SLC28A3 SLC29A1 SLC29A2 SLC29A3 SLC29A4	Homo sapiens (human)
PDH complex synthesizes acetyl-CoA from PYR	Dihydrolipoyl dehydrogenase, mitochondrial Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pyruvate dehydrogenase protein X component, mitochondrial	O00330 P08559 P09622 P10515 P11177 P29803	DLAT DLD DLTA GCSL LAD PDHA1 PDHA2 PDHAL PDHB PDHX PDX1 PHE1A PHE1B PHE3	Homo sapiens (human)
Signaling by Retinoic Acid	Cellular retinoic acid-binding protein 2 Dihydrolipoyl dehydrogenase, mitochondrial Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Fatty acid-binding protein 5 Peroxisome proliferator-activated receptor delta Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pyruvate dehydrogenase protein X component, mitochondrial Retinoic acid receptor RXR-alpha Retinoic acid receptor RXR-beta Retinoic acid receptor RXR-gamma Retinoic acid receptor alpha Retinoic acid receptor beta Retinoic acid receptor gamma [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	O00330 P08559 P09622 P10276 P10515 P10826 P11177 P13631 P19793 P28702 P29373 P29803 P48443 Q01469 Q03181 Q15118 Q15119 Q15120 Q16654	CRABP2 DLAT DLD DLTA FABP5 GCSL HAP LAD NR1B1 NR1B2 NR1B3 NR1C2 NR2B1 NR2B2 NR2B3 PDHA1 PDHA2 PDHAL PDHB PDHK1 PDHK2 PDHK3 PDHK4 PDHX PDK1 PDK2 PDK3 PDK4 PDX1 PHE1A PHE1B PHE3 PPARB PPARD RARA RARB RARG RXRA RXRB RXRG	Homo sapiens (human)
Regulation of pyruvate dehydrogenase (PDH) complex	Dihydrolipoyl dehydrogenase, mitochondrial Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Maleylacetoacetate isomerase NAD-dependent protein lipoamidase sirtuin-4, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial Pyruvate dehydrogenase protein X component, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial	O00330 O43708 P08559 P09622 P10515 P11177 P29803 Q15118 Q15119 Q15120 Q16654 Q8NCN5 Q9P0J1 Q9P2J9 Q9Y6E7	DLAT DLD DLTA GCSL GSTZ1 KIAA1348 KIAA1990 LAD MAAI PDHA1 PDHA2 PDHAL PDHB PDHK1 PDHK2 PDHK3 PDHK4 PDHX PDK1 PDK2 PDK3 PDK4 PDP PDP1 PDP2 PDPR PDX1 PHE1A PHE1B PHE3 PPM2C SIR2L4 SIRT4	Homo sapiens (human)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	Erythropoietin receptor Erythropoietin GRB2-associated-binding protein 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Phosphoinositide 3-kinase regulatory subunit 5 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn	O00329 O60674 P01588 P07948 P19235 P27986 P42336 P42338 P48736 Q13480 Q8WYR1 Q9Y4H2	EPO EPOR GAB1 GRB1 IRS2 JAK2 JTK8 LYN PIK3C1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R5	Homo sapiens (human)
Signaling by CSF1 (M-CSF) in myeloid cells	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 E3 ubiquitin-protein ligase CBL GRB2-associated-binding protein 2 GRB2-associated-binding protein 3 GRB2-related adapter protein 2 GTPase KRas Interleukin-34 Macrophage colony-stimulating factor 1 receptor Macrophage colony-stimulating factor 1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Polyubiquitin-B Polyubiquitin-C Proto-oncogene tyrosine-protein kinase Src SHC-transforming protein 1 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Son of sevenless homolog 1 THO complex subunit 5 Tyrosine-protein kinase Fyn Tyrosine-protein kinase HCK Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes Tyrosine-protein phosphatase non-receptor type 11 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00329 O15357 O75791 P01116 P06241 P07333 P07947 P07948 P08631 P09603 P0CG47 P0CG48 P12931 P16885 P22681 P27986 P29353 P40763 P42224 P42336 P42338 P62979 P62987 Q06124 Q07889 Q13769 Q6ZMJ4 Q8WWW8 Q92835 Q9UQC2	APRF C16orf77 C22orf19 CBL CBL2 CSF1 CSF1R FMS FYN GAB2 GAB3 GADS GRAP2 GRB1 GRB2L GRID HCK IL34 INPP5D INPPL1 JTK8 KIAA0571 KIAA0983 KRAS KRAS2 LYN PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PLCG2 PTP2C PTPN11 RASK2 RNF55 RPS27A SHC SHC1 SHCA SHIP SHIP1 SHIP2 SHPTP2 SOS1 SRC SRC1 STAT1 STAT3 THOC5 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 YES YES1	Homo sapiens (human)
Regulation of signaling by CBL	Adapter molecule crk B-cell linker protein Crk-like protein E3 ubiquitin-protein ligase CBL Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Proto-oncogene vav Rap guanine nucleotide exchange factor 1 Tyrosine-protein kinase Fyn Tyrosine-protein kinase HCK Tyrosine-protein kinase Lyn Tyrosine-protein kinase SYK Tyrosine-protein kinase Yes	O00329 O00459 P06241 P07947 P07948 P08631 P15498 P22681 P27986 P42336 P42338 P43405 P46108 P46109 Q13905 Q8WV28 Q92569	BASH BLNK CBL CBL2 CRK CRKL FYN GRB1 GRF2 HCK JTK8 LYN PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 RAPGEF1 RNF55 SLP65 SYK VAV VAV1 YES YES1	Homo sapiens (human)
Interleukin-3, Interleukin-5 and GM-CSF signaling	14-3-3 protein zeta/delta Cytokine receptor common subunit beta Granulocyte-macrophage colony-stimulating factor receptor subunit alpha Granulocyte-macrophage colony-stimulating factor Interleukin-3 receptor subunit alpha Interleukin-3 Interleukin-5 receptor subunit alpha Interleukin-5 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Proto-oncogene vav SHC-transforming protein 1 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Tec Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6 cAMP-dependent protein kinase catalytic subunit alpha	O00329 O00459 O60674 P04141 P05113 P08700 P15498 P15509 P17612 P26951 P27986 P29350 P29353 P32927 P42229 P42336 P42338 P42680 P51692 P63104 Q01344 Q06124 Q92569	CSF2 CSF2R CSF2RA CSF2RB CSF2RY GMCSF GRB1 HCP IL3 IL3R IL3RA IL3RB IL5 IL5R IL5RA IL5RB JAK2 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PKACA PRKACA PSCTK4 PTP1C PTP2C PTPN11 PTPN6 SHC SHC1 SHCA SHPTP2 STAT5 STAT5A STAT5B TEC VAV VAV1 YWHAZ	Homo sapiens (human)
Interleukin receptor SHC signaling	Cytokine receptor common subunit beta Cytokine receptor common subunit gamma GRB2-associated-binding protein 2 Granulocyte-macrophage colony-stimulating factor receptor subunit alpha Granulocyte-macrophage colony-stimulating factor Interleukin-2 receptor subunit alpha Interleukin-2 receptor subunit beta Interleukin-2 Interleukin-3 receptor subunit alpha Interleukin-3 Interleukin-5 receptor subunit alpha Interleukin-5 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform SHC-transforming protein 1 Son of sevenless homolog 1 Tyrosine-protein kinase JAK1 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase JAK3 Tyrosine-protein phosphatase non-receptor type 6	O00329 O00459 O15357 O60674 P01589 P04141 P05113 P08700 P14784 P15509 P23458 P26951 P27986 P29350 P29353 P31785 P32927 P42336 P42338 P52333 P60568 Q01344 Q07889 Q92569 Q92835 Q9UQC2	CSF2 CSF2R CSF2RA CSF2RB CSF2RY GAB2 GMCSF GRB1 HCP IL15RB IL2 IL2RA IL2RB IL2RG IL3 IL3R IL3RA IL3RB IL5 IL5R IL5RA IL5RB INPP5D INPPL1 JAK1 JAK1A JAK1B JAK2 JAK3 KIAA0571 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTP1C PTPN6 SHC SHC1 SHCA SHIP SHIP1 SHIP2 SOS1	Homo sapiens (human)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	3-phosphoinositide-dependent protein kinase 1 Adenylate cyclase type 1 Adenylate cyclase type 2 Adenylate cyclase type 3 Adenylate cyclase type 4 Adenylate cyclase type 5 Adenylate cyclase type 6 Adenylate cyclase type 7 Adenylate cyclase type 8 Adenylate cyclase type 9 Cadherin-5 Calcitonin gene-related peptide type 1 receptor Calmodulin-1 Calpain small subunit 1 Calpain small subunit 2 Calpain-2 catalytic subunit Catenin beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(q) subunit alpha Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Guanine nucleotide-binding protein subunit alpha-11 Guanine nucleotide-binding protein subunit beta-4 Guanine nucleotide-binding protein subunit beta-5 Matrix metalloproteinase-14 Nitric oxide synthase 3 P2Y purinoceptor 2 Pannexin-1 Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Piezo-type mechanosensitive ion channel component 1 Platelet endothelial cell adhesion molecule Pro-adrenomedullin Proline-rich protein 5 RAC-alpha serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Receptor activity-modifying protein 2 Serine/threonine-protein kinase N2 Serine/threonine-protein kinase mTOR Talin-1 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Transient receptor potential cation channel subfamily V member 4 Tyrosine-protein kinase Fyn Vascular endothelial growth factor receptor 2 Vascular endothelial growth factor receptor 3 Vinculin cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit	O00329 O00459 O14610 O14775 O15530 O43306 O60262 O60266 O60503 O60895 O95622 P04632 P06241 P0DP23 P10644 P13861 P16284 P16520 P17612 P17655 P18206 P22612 P22694 P29474 P29992 P31321 P31323 P31749 P33151 P35222 P35318 P35916 P35968 P40145 P41231 P42336 P42338 P42345 P50148 P50150 P50151 P50281 P51828 P59768 P61952 P62873 P62879 P63092 P63211 P63215 P63218 P85299 Q08462 Q08828 Q16513 Q16602 Q5JWF2 Q6R327 Q8NFM4 Q92508 Q96L46 Q96RD7 Q9BPZ7 Q9BVC4 Q9HAV0 Q9HBA0 Q9P2W3 Q9UBI6 Q9UK08 Q9Y490	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADM AKT1 AM CALCRL CALM CALM1 CAM CAM1 CANPL2 CAPN2 CAPN4 CAPNS CAPNS1 CAPNS2 CDH5 CGRPR CTNNB CTNNB1 FAM38A FLK1 FLT4 FRAP FRAP1 FRAP2 FYN GA11 GAQ GBL GNA11 GNAQ GNAS GNAS1 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG9 GNGT1 GNGT10 GNGT11 GNGT2 GNGT3 GNGT4 GNGT5 GNGT7 GNGT8 GNGT9 GSP KDR KIAA0037 KIAA0233 KIAA0422 KIAA0511 KIAA0520 KIAA1027 KIAA1060 KIAA1999 LST8 MAPKAP1 MIP1 MLST8 MMP14 MRS1 MTOR NOS3 P2RU1 P2RY2 PANX1 PDK1 PDPK1 PECAM1 PIEZO1 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R2 PKACA PKB PKN2 PKR1 PKR2 PRK2 PRKACA PRKACB PRKACG PRKAR1 PRKAR1A PRKAR1B PRKAR2 PRKAR2A PRKAR2B PRKCL2 PROTOR1 PRR5 RAC RAFT1 RAMP2 RAPT1 RICTOR SIN1 TLN TLN1 TRPV4 TSE1 VCL VEGFR2 VEGFR3 VRL2 VROAC	Homo sapiens (human)
Constitutive Signaling by Aberrant PI3K in Cancer	Amphiregulin B-lymphocyte antigen CD19 BDNF/NT-3 growth factors receptor Beta-klotho Brain-derived neurotrophic factor Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Mast/stem cell growth factor receptor Kit NT-3 growth factor receptor Neurotrophin-3 Neurotrophin-4 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphoinositide 3-kinase adapter protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Proto-oncogene vav Protransforming growth factor alpha Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Rho-related GTP-binding protein RhoG Striatin T-cell receptor-associated transmembrane adapter 1 T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein phosphatase non-receptor type 11	O00329 O00459 O14511 O14944 O15520 O43320 O43815 O76093 O95750 P00533 P01127 P01133 P01135 P03372 P04626 P05230 P06239 P06241 P08581 P08620 P09038 P09619 P10721 P10747 P10767 P11487 P12931 P14210 P15153 P15391 P15498 P15514 P16234 P20783 P21781 P22455 P23560 P27986 P31371 P33681 P34130 P35070 P35568 P36888 P42081 P42336 P42338 P49771 P56975 P63000 P84095 Q02297 Q06124 Q13480 Q16288 Q16620 Q6PIZ9 Q6UW88 Q6ZUJ8 Q86Z14 Q8WU20 Q8WWG1 Q92569 Q92731 Q99075 Q9GZV9 Q9HCT0 Q9NP95 Q9UQC2 Q9Y4H2	AREG AREGB ARHG BCAP BDNF BTC CD135 CD19 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ESR ESR1 ESR2 ESTRB FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 FYN GAB1 GAB2 GGF GRB1 HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRGA HST HST2 HSTF1 HSTF2 HYPF INT2 IRS1 IRS2 JTK2 KGF KIAA0571 KIT KLB KS3 LAB7 LCK MET MLN19 NDF NEU NGL NR3A1 NR3A2 NRG1 NRG2 NRG3 NRG4 NTAK NTF3 NTF4 NTF5 NTRK2 NTRK3 PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PIK3AP1 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTP2C PTPN11 RAC1 RAC2 RHEPDGFRA RHOG SCFR SDGF SHPTP2 SIS SMDF SRC SRC1 STK1 STRN TC25 TCRIM TGFA TKF TRAT1 TRKB TRKC VAV VAV1	Homo sapiens (human)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Amphiregulin B-lymphocyte antigen CD19 BDNF/NT-3 growth factors receptor Beta-klotho Brain-derived neurotrophic factor Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin receptor Insulin Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-like 1 Interleukin-33 Mast/stem cell growth factor receptor Kit Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Myeloid differentiation primary response protein MyD88 NT-3 growth factor receptor Neurotrophin-3 Neurotrophin-4 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Phosphatidylinositol 4-phosphate 5-kinase type-1 beta Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Phosphoinositide 3-kinase adapter protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Proto-oncogene vav Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase Radiation-inducible immediate-early gene IEX-1 Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Rho-related GTP-binding protein RhoG Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Striatin T-cell receptor-associated transmembrane adapter 1 T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 TNF receptor-associated factor 6 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein phosphatase non-receptor type 11	O00329 O00459 O14511 O14944 O14986 O15520 O43320 O43815 O60331 O76093 O95750 O95760 P00533 P01127 P01133 P01135 P01308 P03372 P04626 P05230 P06213 P06239 P06241 P08581 P08620 P09038 P09619 P10721 P10747 P10767 P11487 P12931 P14210 P15153 P15391 P15498 P15514 P16234 P20783 P21781 P22455 P23560 P27361 P27986 P28482 P30153 P30154 P31371 P31749 P33681 P34130 P35070 P35568 P36888 P42081 P42336 P42338 P46695 P48426 P49771 P51617 P56975 P62714 P63000 P67775 P78356 P84095 Q01638 Q02297 Q06124 Q13362 Q13480 Q14738 Q15172 Q15173 Q16288 Q16537 Q16620 Q6PIZ9 Q6UW88 Q6ZUJ8 Q86Z14 Q8TBX8 Q8WU20 Q8WWG1 Q92569 Q92731 Q99075 Q99755 Q99836 Q9GZV9 Q9HCT0 Q9NP95 Q9NWZ3 Q9UQC2 Q9Y4H2 Q9Y4K3	AKT1 AREG AREGB ARHG BCAP BDNF BTC C9orf26 CD135 CD19 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 DER4 DIF2 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ERK1 ERK2 ESR ESR1 ESR2 ESTRB FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 FYN GAB1 GAB2 GGF GRB1 HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRGA HST HST2 HSTF1 HSTF2 HYPF IER3 IEX1 IL1F11 IL1RL1 IL33 INS INSR INT2 IRAK IRAK1 IRAK4 IRS1 IRS2 JTK2 KGF KIAA0044 KIAA0571 KIAA0589 KIT KLB KS3 LAB7 LCK MAPK1 MAPK3 MET MLN19 MYD88 NDF NEU NFHEV NGL NR3A1 NR3A2 NRG1 NRG2 NRG3 NRG4 NTAK NTF3 NTF4 NTF5 NTRK2 NTRK3 PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PI5P4KA PIK3AP1 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PIP5K2 PIP5K2A PIP5K2B PIP5K2C PKB PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRG1 PRKM1 PRKM2 PRKM3 PTP2C PTPN11 RAC RAC1 RAC2 RHEPDGFRA RHOG RNF85 SCFR SDGF SHPTP2 SIS SMDF SRC SRC1 ST2 STK1 STM7 STRN T1 TC25 TCRIM TGFA TKF TRAF6 TRAT1 TRKB TRKC VAV VAV1	Homo sapiens (human)
RET signaling	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Artemin Docking protein 1 Docking protein 2 Docking protein 4 Docking protein 5 Docking protein 6 Fibroblast growth factor receptor substrate 2 GDNF family receptor alpha-1 GDNF family receptor alpha-2 GDNF family receptor alpha-3 GDNF family receptor alpha-4 GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Glial cell line-derived neurotrophic factor Growth factor receptor-bound protein 10 Growth factor receptor-bound protein 7 Insulin receptor substrate 2 Mitogen-activated protein kinase 7 Neurturin PDZ and LIM domain protein 7 Persephin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Protein kinase C alpha type Proto-oncogene tyrosine-protein kinase receptor Ret Rap1 GTPase-activating protein 1 SH3 and multiple ankyrin repeat domains protein 3 SHC-transforming protein 1 SHC-transforming protein 3 Son of sevenless homolog 1 Tyrosine-protein phosphatase non-receptor type 11 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma	O00329 O00451 O00459 O60496 O60542 O60609 P07949 P17252 P17612 P19174 P22612 P22694 P27986 P29353 P39905 P42336 P42338 P47736 P56159 Q06124 Q07889 Q13164 Q13322 Q13480 Q14451 Q5T4W7 Q6PKX4 Q8TEW6 Q8WU20 Q92529 Q92569 Q99704 Q99748 Q9BYB0 Q9GZZ7 Q9NR12 Q9P104 Q9UQC2 Q9Y4H2	ARTN BMK1 C20orf180 CDHF12 CDHR16 DOK1 DOK2 DOK4 DOK5 DOK5L DOK6 ENIGMA ERK5 EVN FRS2 GAB1 GAB2 GDNF GDNFRA GDNFRB GFRA1 GFRA2 GFRA3 GFRA4 GRB1 GRB10 GRB7 GRBIR IRS2 KIAA0207 KIAA0474 KIAA0571 KIAA1650 MAPK7 NRTN NSHC PDLIM7 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PKACA PKCA PLC1 PLCG1 PRKACA PRKACB PRKACG PRKCA PRKM7 PROSAP2 PSAP2 PSPN PTC PTP2C PTPN11 RAP1GA1 RAP1GAP RET RETL1 RETL2 SHANK3 SHC SHC1 SHC3 SHCA SHCC SHPTP2 SOS1 TRNR1 TRNR2	Homo sapiens (human)
Synthesis of PIPs at the plasma membrane	ADP-ribosylation factor 1 Cytoplasmic tyrosine-protein kinase BMX Inositol polyphosphate 4-phosphatase type II Inositol polyphosphate 5-phosphatase K Inositol polyphosphate 5-phosphatase OCRL Inositol polyphosphate-4-phosphatase type I A Myotubularin-related protein 13 Myotubularin-related protein 9 Myotubularin Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A Phosphatidylinositol 4-kinase type 2-alpha Phosphatidylinositol 4-kinase type 2-beta Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Phosphatidylinositol 4-phosphate 5-kinase type-1 beta Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8 Phosphatidylinositol-3-phosphate phosphatase MTMR1 Phosphoinositide 3-kinase regulatory subunit 5 Phosphoinositide 3-kinase regulatory subunit 6 Pleckstrin homology domain-containing family A member 1 Pleckstrin homology domain-containing family A member 2 Pleckstrin homology domain-containing family A member 3 Pleckstrin homology domain-containing family A member 4 Pleckstrin homology domain-containing family A member 5 Pleckstrin homology domain-containing family A member 6 Pleckstrin homology domain-containing family A member 8 RUN and FYVE domain-containing protein 1 Ras-related protein Rab-14 Ras-related protein Rab-4A Ras-related protein Rab-5A Synaptojanin-1 Synaptojanin-2 Tyrosine-protein phosphatase non-receptor type 13	O00329 O00443 O00459 O00750 O14986 O15056 O15327 O15357 O43426 O60331 O75747 P20338 P20339 P27986 P42336 P42338 P48426 P48736 P51813 P60484 P61106 P78356 P84077 Q01968 Q12923 Q13496 Q13613 Q13614 Q13615 Q15735 Q5UE93 Q86WG5 Q8NCE2 Q8TBX8 Q8TCG2 Q8WYR1 Q92569 Q92835 Q96EF0 Q96JA3 Q96PE3 Q96QG7 Q96T51 Q99755 Q9BT40 Q9BTU6 Q9H4M7 Q9HAU0 Q9HB19 Q9HB20 Q9HB21 Q9Y217 Q9Y2H5	ARF1 BMX C17orf38 C3orf29 C8orf9 CG2 CMT4B2 FAPP1 FAPP2 GRB1 INPP4A INPP4B INPP5D INPP5J INPP5K INPPL1 KIAA0348 KIAA0371 KIAA0589 KIAA0910 KIAA0969 KIAA1073 KIAA1686 KIAA1766 MMAC1 MTM1 MTMR1 MTMR13 MTMR14 MTMR2 MTMR3 MTMR6 MTMR8 MTMR9 OCRL OCRL1 PEPP1 PEPP2 PEPP3 PI4K2A PI4K2B PI5P4KA PIB5PA PIK3C1 PIK3C2A PIK3C2B PIK3C2G PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PIP5K2 PIP5K2A PIP5K2B PIP5K2C PIPP PLEKHA1 PLEKHA2 PLEKHA3 PLEKHA4 PLEKHA5 PLEKHA6 PLEKHA8 PNP1 PPS PTEN PTP1E PTPL1 PTPN13 RAB14 RAB4 RAB4A RAB5 RAB5A RABIP4 RUFY1 SBF2 SHIP SHIP1 SHIP2 SKIP STM7 SYNJ1 SYNJ2 TAPP1 TAPP2 TEP1 ZFYVE10 ZFYVE12	Homo sapiens (human)
Circadian Clock	3'-5' exoribonuclease HELZ2 Basic helix-loop-helix ARNT-like protein 1 CREB-binding protein CREB-regulated transcription coactivator 1 CREB-regulated transcription coactivator 2 CREB-regulated transcription coactivator 3 Casein kinase I isoform delta Casein kinase I isoform epsilon Chromodomain-helicase-DNA-binding protein 9 Circadian locomoter output cycles protein kaput Class E basic helix-loop-helix protein 41 Cryptochrome-1 Cryptochrome-2 Cullin-1 Cyclic AMP-dependent transcription factor ATF-2 F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 F-box/LRR-repeat protein 3 F-box/WD repeat-containing protein 1A Glucocorticoid receptor Histone acetyltransferase p300 Histone deacetylase 3 Histone-arginine methyltransferase CARM1 Hypoxia-inducible factor 1-alpha Mediator of RNA polymerase II transcription subunit 1 Myocyte-specific enhancer factor 2C Myocyte-specific enhancer factor 2D NAD-dependent protein deacetylase sirtuin-1 Neuronal PAS domain-containing protein 2 Nuclear factor interleukin-3-regulated protein Nuclear receptor ROR-alpha Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 6 Nuclear receptor corepressor 1 Nuclear receptor subfamily 1 group D member 1 Nuclear receptor-interacting protein 1 Period circadian protein homolog 1 Period circadian protein homolog 2 Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Polyubiquitin-B Polyubiquitin-C RNA-binding protein 4 Retinoic acid receptor RXR-alpha Retinoic acid-induced protein 1 S-phase kinase-associated protein 1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Serine/threonine-protein kinase SIK1 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Trimethylguanosine synthase Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00327 O15055 O15379 O15516 O15534 O60907 O75376 P04150 P0CG47 P0CG48 P15336 P19793 P20393 P35398 P36873 P48552 P48730 P49674 P57059 P62136 P62140 P62979 P62987 P63208 Q06413 Q07869 Q09472 Q13616 Q14686 Q14814 Q15596 Q15648 Q15788 Q16526 Q16649 Q16665 Q3L8U1 Q49AN0 Q53ET0 Q6STE5 Q6UUV7 Q6UUV9 Q7Z5J4 Q86X55 Q92793 Q96EB6 Q96RS0 Q99743 Q9BWF3 Q9BYK8 Q9BZK7 Q9C0J9 Q9UBK2 Q9UKT7 Q9Y297	AIB3 ARC205 ARNTL ATF2 BAF60C BHLHB3 BHLHE41 BHLHE5 BHLHE74 BHLHE75 BHLHE78 BHLHE8 BHLHE9 BMAL1 BTRC BTRCP CARM1 CBP CHD9 CLOCK CREB2 CREBBP CREBP1 CRSP1 CRSP200 CRTC1 CRTC2 CRTC3 CRY1 CRY2 CSNK1D CSNK1E CUL1 DEC2 DRIP205 DRIP230 E4BP4 EAR1 EMC19 EP300 FBL3A FBW1A FBXL3 FBXL3A FBXW1A GRL HCA137 HCKID HDAC3 HELZ2 HIF1A HREV IL3BP1 IRA1 KIAA0181 KIAA0308 KIAA0334 KIAA0347 KIAA0482 KIAA0616 KIAA0658 KIAA1047 KIAA1769 KIAA1820 KISH2 LEM6 MECT1 MED1 MEF2C MEF2D MOP1 MOP3 MOP4 NCOA1 NCOA2 NCOA6 NCOA6IP NCOR1 NFIL3 NPAS2 NR1C1 NR1D1 NR1F1 NR2B1 NR3C1 NRIP1 OCP2 P300 PASD3 PASD4 PASD8 PBP PER PER1 PER2 PGC1 PGC1A PHLL1 PIMT PPAR PPARA PPARBP PPARGBP PPARGC1 PPARGC1A PPP1A PPP1CA PPP1CB PPP1CC PRIC285 PRIC320 PRMT4 RAI1 RAP250 RB18A RBM4 RBM4A RIGUI RORA RPS27A RXRA RZRA SHARP1 SIK SIK1 SIR2L1 SIRT1 SKP1 SKP1A SMARCD3 SNF1LK SRC1 SRC2 TBL1 TBL1X TBL1XR1 TBLR1 TCEB1L TGS1 THRAL TIF2 TORC1 TORC2 TORC3 TRAP220 TRBP TRIP2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 WAMTP1	Homo sapiens (human)
BMAL1:CLOCK,NPAS2 activates circadian gene expression	3'-5' exoribonuclease HELZ2 Basic helix-loop-helix ARNT-like protein 1 Basic helix-loop-helix ARNT-like protein 2 CREB-binding protein Chromodomain-helicase-DNA-binding protein 9 Circadian locomoter output cycles protein kaput Class E basic helix-loop-helix protein 40 Class E basic helix-loop-helix protein 41 Coagulation factor VII D site-binding protein F-box-like/WD repeat-containing protein TBL1X F-box-like/WD repeat-containing protein TBL1XR1 Histone-arginine methyltransferase CARM1 Krueppel-like factor 15 Mediator of RNA polymerase II transcription subunit 1 Neuronal PAS domain-containing protein 2 Nicotinamide phosphoribosyltransferase Nocturnin Nuclear receptor coactivator 1 Nuclear receptor coactivator 2 Nuclear receptor coactivator 6 Peroxisome proliferator-activated receptor alpha Plasminogen activator inhibitor 1 Retinoic acid receptor RXR-alpha SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Trimethylguanosine synthase Vasopressin-neurophysin 2-copeptin	O00327 O14503 O15516 O60907 P01185 P05121 P08709 P19793 P43490 Q07869 Q10586 Q14686 Q15596 Q15648 Q15788 Q3L8U1 Q6STE5 Q86X55 Q8WYA1 Q92793 Q96RS0 Q99743 Q9BYK8 Q9BZK7 Q9C0J9 Q9UIH9 Q9UK39	AIB3 ARC205 ARNTL ARNTL2 ARVP AVP BAF60C BHLHB2 BHLHB3 BHLHE40 BHLHE41 BHLHE5 BHLHE6 BHLHE74 BHLHE75 BHLHE8 BHLHE9 BMAL1 BMAL2 CARM1 CBP CCR4 CCRN4L CHD9 CLIF CLOCK CREBBP CRSP1 CRSP200 DBP DEC1 DEC2 DRIP205 DRIP230 F7 HCA137 HELZ2 IRA1 KIAA0181 KIAA0308 KIAA0334 KIAA1769 KISH2 KKLF KLF15 MED1 MOP3 MOP4 MOP9 NAMPT NCOA1 NCOA2 NCOA6 NCOA6IP NOC NOCT NPAS2 NR1C1 NR2B1 PAI1 PASD3 PASD4 PASD9 PBEF PBEF1 PBP PIMT PLANH1 PPAR PPARA PPARBP PPARGBP PRIC285 PRIC320 PRMT4 RAP250 RB18A RXRA SERPINE1 SHARP1 SHARP2 SMARCD3 SRC1 SRC2 STRA13 TBL1 TBL1X TBL1XR1 TBLR1 TGS1 TIF2 TRAP220 TRBP TRIP2 VP	Homo sapiens (human)
Activation of the pre-replicative complex	Cell division control protein 45 homolog Cell division control protein 6 homolog Cell division cycle 7-related protein kinase Cyclin-dependent kinase 2 DNA helicase MCM8 DNA polymerase alpha catalytic subunit DNA polymerase alpha subunit B DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA primase large subunit DNA primase small subunit DNA replication factor Cdt1 DNA replication licensing factor MCM2 DNA replication licensing factor MCM3 DNA replication licensing factor MCM4 DNA replication licensing factor MCM5 DNA replication licensing factor MCM6 DNA replication licensing factor MCM7 Geminin Origin recognition complex subunit 1 Origin recognition complex subunit 2 Origin recognition complex subunit 3 Origin recognition complex subunit 4 Origin recognition complex subunit 5 Origin recognition complex subunit 6 Protein DBF4 homolog A Protein MCM10 homolog Replication protein A 14 kDa subunit Replication protein A 30 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit	O00311 O43913 O43929 O75419 O75496 P09884 P15927 P24941 P25205 P27694 P33991 P33992 P33993 P35244 P49642 P49643 P49736 P56282 Q07864 Q13156 Q13415 Q13416 Q14181 Q14566 Q7L590 Q99741 Q9H211 Q9NR33 Q9NRF9 Q9UBD5 Q9UBU7 Q9UJA3 Q9Y5N6	ASK BM28 C20orf154 CCNL1 CDC18L CDC21 CDC45 CDC45L CDC45L2 CDC46 CDC47 CDC6 CDC7 CDC7L1 CDCL1 CDK2 CDKN2 CDT1 CHRAC17 DBF4 DBF4A DPE2 GMNN KIAA0030 LATHEO MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC1L ORC2 ORC2L ORC3 ORC3L ORC4 ORC4L ORC5 ORC5L ORC6 ORC6L PARC1 POLA POLA1 POLA2 POLE POLE1 POLE2 POLE3 POLE4 PRIM1 PRIM2 PRIM2A REPA1 REPA2 REPA3 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA4 RPA70 ZDBF1	Homo sapiens (human)
Activation of ATR in response to replication stress	ATR-interacting protein Cell cycle checkpoint control protein RAD9A Cell cycle checkpoint control protein RAD9B Cell cycle checkpoint protein RAD17 Cell cycle checkpoint protein RAD1 Cell division control protein 45 homolog Cell division control protein 6 homolog Cell division cycle 7-related protein kinase Checkpoint protein HUS1 Claspin Cyclin-dependent kinase 2 DNA helicase MCM8 DNA replication licensing factor MCM2 DNA replication licensing factor MCM3 DNA replication licensing factor MCM4 DNA replication licensing factor MCM5 DNA replication licensing factor MCM6 DNA replication licensing factor MCM7 M-phase inducer phosphatase 1 M-phase inducer phosphatase 3 Origin recognition complex subunit 1 Origin recognition complex subunit 2 Origin recognition complex subunit 3 Origin recognition complex subunit 4 Origin recognition complex subunit 5 Origin recognition complex subunit 6 Protein DBF4 homolog A Protein MCM10 homolog Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Serine/threonine-protein kinase ATR Serine/threonine-protein kinase Chk1	O00311 O14757 O43913 O43929 O60671 O60921 O75419 O75943 P15927 P24941 P25205 P27694 P30304 P30307 P33991 P33992 P33993 P35244 P35249 P35250 P40937 P40938 P49736 Q13415 Q13416 Q13535 Q14566 Q6WBX8 Q7L590 Q8WXE1 Q99638 Q99741 Q9HAW4 Q9UBD5 Q9UBU7 Q9UJA3 Q9Y5N6	AGS1 ASK ATR ATRIP BM28 C20orf154 CCNL1 CDC18L CDC21 CDC25A CDC25C CDC45 CDC45L CDC45L2 CDC46 CDC47 CDC6 CDC7 CDC7L1 CDCL1 CDK2 CDKN2 CHEK1 CHK1 CLSPN DBF4 DBF4A FRP1 HUS1 KIAA0030 LATHEO MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 ORC1 ORC1L ORC2 ORC2L ORC3 ORC3L ORC4 ORC4L ORC5 ORC5L ORC6 ORC6L PARC1 R24L RAD1 RAD17 RAD9A RAD9B REC1 REPA1 REPA2 REPA3 RFC2 RFC3 RFC4 RFC5 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 ZDBF1	Homo sapiens (human)
Transcriptional Regulation by E2F6	Apoptotic protease-activating factor 1 Breast cancer type 1 susceptibility protein Cell division cycle 7-related protein kinase Chromobox protein homolog 3 Chromobox protein homolog 5 DNA endonuclease RBBP8 DNA repair protein RAD51 homolog 1 E3 ubiquitin-protein ligase RING1 E3 ubiquitin-protein ligase RING2 Enhancer of polycomb homolog 1 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Histone-lysine N-methyltransferase EZH2 Lethal(3)malignant brain tumor-like protein 2 MAX gene-associated protein Polycomb complex protein BMI-1 Polycomb group RING finger protein 2 Polycomb group RING finger protein 6 Polycomb protein EED Polycomb protein SUZ12 Polyhomeotic-like protein 1 Polyhomeotic-like protein 3 Protein UXT Protein max RING1 and YY1-binding protein Ribonucleoside-diphosphate reductase subunit M2 Serine/threonine-protein kinase Chk1 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F6 YY1-associated factor 2	O00311 O14727 O14757 O75461 O75530 P31350 P35226 P35227 P38398 P45973 P61244 P78364 Q01094 Q06587 Q06609 Q09028 Q13185 Q14186 Q14188 Q15022 Q15910 Q16576 Q8IWI9 Q8IY57 Q8N488 Q8NDX5 Q969R5 Q96KQ7 Q99496 Q99708 Q9BYE7 Q9H2F5 Q9H9B1 Q9UBK9	APAF1 BAP1 BAT8 BHLHD4 BMI1 BRCA1 C6orf30 CBX3 CBX5 CDC7 CDC7L1 CHEK1 CHET9 CHK1 CTIP DEDAF DING DP1 DP2 E2F1 E2F6 EDR1 EDR3 EED EHMT1 EHMT2 EPC1 EUHMTASE1 EZH2 G9A GLP HIPI3 HP1A JJAZ1 KIAA0160 KIAA0413 KIAA0518 KIAA1876 KMT1C KMT1D KMT6 L3MBTL2 MAD5 MAX MBLR MEL18 MGA NG36 PCGF2 PCGF4 PCGF6 PH1 PH3 PHC1 PHC3 RAD51 RAD51A RBAP46 RBAP48 RBBP3 RBBP4 RBBP7 RBBP8 RECA RING1 RING1A RING1B RNF1 RNF110 RNF134 RNF2 RNF51 RNF53 RR2 RRM2 RYBP SUZ12 TFDP1 TFDP2 UXT YAF2 YEAF1 ZNF144	Homo sapiens (human)
RHOU GTPase cycle	ARF GTPase-activating protein GIT1 ARF GTPase-activating protein GIT2 Cell division control protein 42 homolog Clathrin heavy chain 1 Cytoplasmic protein NCK2 DEP domain-containing protein 1B Disks large homolog 5 Dystonin Ephrin type-A receptor 2 Hepatocyte growth factor-regulated tyrosine kinase substrate Inactive tyrosine-protein kinase PEAK1 Intersectin-2 NEDD4-like E3 ubiquitin-protein ligase WWP2 Partitioning defective 6 homolog alpha Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Protein-tyrosine kinase 2-beta Proto-oncogene tyrosine-protein kinase Src Ras GTPase-activating-like protein IQGAP1 Rho GTPase-activating protein 30 Rho GTPase-activating protein 31 Rho guanine nucleotide exchange factor 6 Rho guanine nucleotide exchange factor 7 Rho-related GTP-binding protein RhoU SH2/SH3 adapter protein NCK1 SLIT-ROBO Rho GTPase-activating protein 2 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase PAK 4 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Spectrin alpha chain, non-erythrocytic 1 Spectrin beta chain, non-erythrocytic 1 Thioredoxin-like protein 1 Ubiquitin carboxyl-terminal hydrolase 9X Unconventional myosin-VI Vang-like protein 1 tRNA (34-2'-O)-methyltransferase regulator WDR6	O00308 O00459 O14964 O43396 O43639 O75044 O75886 O75914 O96013 P12931 P16333 P27986 P29317 P46940 P60953 Q00610 Q01082 Q03001 Q13153 Q13177 Q13813 Q14155 Q14161 Q14289 Q15052 Q2M1Z3 Q7L0Q8 Q7Z6I6 Q8TAA9 Q8TDM6 Q8WUY9 Q92783 Q93008 Q9H792 Q9NNW5 Q9NPB6 Q9NZM3 Q9UM54 Q9Y2X7	ARHGAP30 ARHGAP31 ARHGAP34 ARHGEF6 ARHGEF7 ARHU BP230 BP240 BPAG1 CDC42 CDC42L1 CDGAP CLH17 CLTC CLTCL2 COOL1 COOL2 DEPDC1B DFFRX DLG5 DMH DST DT ECK EPHA2 FAK2 FAM FNBP2 G28K GIT1 GIT2 GRB1 GRB4 HBP HGS HRS IQGAP1 ITSN2 KIAA0006 KIAA0034 KIAA0051 KIAA0142 KIAA0148 KIAA0389 KIAA0456 KIAA0583 KIAA0728 KIAA1142 KIAA1204 KIAA1256 KIAA2002 MYO6 NCK NCK1 NCK2 NEAS OPHN3 P85SPR PAK1 PAK2 PAK3 PAK3BP PAK4 PAR6A PARD6A PDLG PEAK1 PIK3R1 PIK3R2 PIXA PIXB PTK2B PYK2 RAFTK RHOU SH3D1B SPTA2 SPTAN1 SPTB2 SPTBN1 SRC SRC1 SRGAP2 SRGAP2A STAM STAM1 STAM2 STB2 SWAP TRP32 TXL TXNL TXNL1 USP9 USP9X VANGL1 WDR6 WRCH1 WWP2 XTP8	Homo sapiens (human)
Presynaptic depolarization and calcium channel opening	Dihydropyridine receptor alpha 2 subunit Voltage-dependent L-type calcium channel subunit beta-1 Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent L-type calcium channel subunit beta-3 Voltage-dependent L-type calcium channel subunit beta-4 Voltage-dependent N-type calcium channel subunit alpha-1B Voltage-dependent P/Q-type calcium channel subunit alpha-1A Voltage-dependent R-type calcium channel subunit alpha-1E Voltage-dependent calcium channel gamma-2 subunit Voltage-dependent calcium channel gamma-4 subunit Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2/delta-3	O00305 O00555 P54284 Q00975 Q02641 Q08289 Q15878 Q8IZS8 Q9NY47 Q9UBN1 Q9UIU0 Q9Y698	CACH4 CACH5 CACH6 CACN3 CACNA1A CACNA1B CACNA1E CACNA2D1 CACNA2D2 CACNA2D3 CACNB1 CACNB2 CACNB3 CACNB4 CACNG2 CACNG4 CACNL1A4 CACNL1A5 CACNL1A6 CACNLB1 CACNLB2 CACNLB3 CACNLB4 KIAA0558 MYSB	Homo sapiens (human)

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